Physical Sciences and Mathematics Commons^™

Modeling And Analyzing Homogeneous Tumor Growth Under Virotherapy, Chayu Yang, Jin Wang

Department of Mathematics: Faculty Publications

We present a mathematical model based on ordinary differential equations to investigate the spatially homogeneous state of tumor growth under virotherapy. The model emphasizes the interaction among the tumor cells, the oncolytic viruses, and the host immune system that generates both innate and adaptive immune responses. We conduct a rigorous equilibrium analysis and derive threshold conditions that determine the growth or decay of the tumor under various scenarios. Numerical simulation results verify our analytical predictions and provide additional insight into the tumor growth dynamics.

A Dynamical System Model Of Dengue Transmission For Rio De Janeiro, Brazil, Gregory Schmidt, Benjamin Whipple, Vinodh Chellamuthu, Xiaoxia Xie

Spora: A Journal of Biomathematics

The dengue virus is a serious concern in many parts of the world, including Brazil. As data indicates, a prominent vector for dengue is the mosquito Aedes aegypti. By using the dengue incidence records from the Brazilian SINAN database, we estimate the population of A. aegypti within the city of Rio de Janeiro. Using historical climate data for Rio de Janeiro and the computed population estimates, we extend an existing model for the population dynamics of mosquitoes to incorporate precipitation in aquatic stages of development for A. aegypti.

Models For Decision-Making - Second Edition, Steven Cosares, Fred Rispoli

Open Educational Resources

Decision-Making often refers to a multi-stage process that starts with some form of introspection or reflection about a situation in which a person or group of people find themselves. These ruminations usually lead to series of questions that need to be answered, or to a set of data that needs to be collected and analyzed, or to some calculations that need to be performed before someone can be in a position to make informed decisions and take appropriate actions.

We provide some simple examples of Quantitative Models, which are often found in a decision-making situation. We focus on the use …

Integrable Systems On Symmetric Spaces From A Quadratic Pencil Of Lax Operators, Rossen Ivanov

Conference papers

The article surveys the recent results on integrable systems arising from quadratic pencil of Lax operator L, with values in a Hermitian symmetric space. The counterpart operator M in the Lax pair defines positive, negative and rational flows. The results are illustrated with examples from the A.III symmetric space. The modeling aspect of the arising higher order nonlinear Schrödinger equations is briefly discussed.

A Path Planning Framework For Multi-Agent Robotic Systems Based On Multivariate Skew-Normal Distributions, Peter Estephan

Theses, Dissertations and Capstones

This thesis presents a path planning framework for a very-large-scale robotic (VLSR) system in an known obstacle environment, where the time-varying distributions of agents are applied to represent the multi-agent robotic system (MARS). A novel family of the multivariate skew-normal (MVSN) distributions is proposed based on the Bernoulli random field (BRF) referred to as the Bernoulli-random-field based skew-normal (BRF-SN) distribution. The proposed distributions are applied to model the agents’ distributions in an obstacle-deployed environment, where the obstacle effect is represented by a skew function and separated from the no-obstacle agents’ distributions. First, the obstacle layout is represented by a Hilbert …

Graphs Without A 2c3-Minor And Bicircular Matroids Without A U3,6-Minor, Daniel Slilaty

Mathematics and Statistics Faculty Publications

In this note we characterize all graphs without a 2C3-minor. A consequence of this result is a characterization of the bicircular matroids with no U3,6-minor.

Odd Solutions To Systems Of Inequalities Coming From Regular Chain Groups, Daniel Slilaty

Mathematics and Statistics Faculty Publications

Hoffman’s theorem on feasible circulations and Ghouila-Houry’s theorem on feasible tensions are classical results of graph theory. Camion generalized these results to systems of inequalities over regular chain groups. An analogue of Camion’s result is proved in which solutions can be forced to be odd valued. The obtained result also generalizes the results of Pretzel and Youngs as well as Slilaty. It is also shown how Ghouila-Houry’s result can be used to give a new proof of the graph- coloring theorem of Minty and Vitaver.

Addressing The Opioid Crisis In The United States And Modeling Its Proposed Interventions, Liza Eubanks

Honors Program Theses

A novel application of compartmental modeling is used to quantitatively study the impact of call centers on influencing an individual’s mindset as they begin or attempt to recover from opioid addiction. The opioid epidemic in the United States has affected millions of Americans, especially in West Virginia. This project studies the effectiveness of call centers in increasing the rate of recovery from opioid abuse. An active response is characterized by an open mindset and acceptance of help from others, while a passive response is defined by a closed mindset and an unwillingness to believe in the real possibility of recovery. …

Foundations Of Wave Phenomena: Complete Version, Charles G. Torre

Foundations of Wave Phenomena

This is the complete version of Foundations of Wave Phenomena. Version 8.3.1.

Please click here to explore the components of this work.

An Adaptive Algorithm For `The Secretary Problem': Alternate Proof Of The Divergence Of A Maximizer Sequence, Andrew Benfante, Xiang Xu

OUR Journal: ODU Undergraduate Research Journal

This paper presents an alternate proof of the divergence of the unique maximizer sequence {𝑥∗ 𝑛} of a function sequence {𝐹𝑛(𝑥)} that is derived from an adaptive algorithm based on the now classic optimal stopping problem, known by many names but here ‘the secretary problem’. The alternate proof uses a result established by Nguyen, Xu, and Zhao (n.d.) regarding the uniqueness of maximizer points of a generalized function sequence {𝑆𝜇,𝜎 𝑛 } and relies on the strict monotonicity of 𝐹𝑛(𝑥) as 𝑛 increases in order to show divergence of {𝑥∗ 𝑛}. Towards this, limits of the exponentiated Gaussian CDF are …

The Lagrangian Formulation For Wave Motion With A Shear Current And Surface Tension, Conor Curtin, Rossen Ivanov

Articles

The Lagrangian formulation for the irrotational wave motion is straightforward and follows from a Lagrangian functional which is the difference between the kinetic and the potential energy of the system. In the case of fluid with constant vorticity, which arises for example when a shear current is present, the separation of the energy into kinetic and potential is not at all obvious and neither is the Lagrangian formulation of the problem. Nevertheless, we use the known Hamiltonian formulation of the problem in this case to obtain the Lagrangian density function, and utilising the Euler-Lagrange equations we proceed to derive some …

Not Your Typical Tower Of Sauron, John Adam

Mathematics & Statistics Faculty Publications

The picture is of the tapering Chester Shot Tower, located in Chester, England. It was built in 1799 for the manufacture of lead shot for use in the Napoleonic Wars. Molten lead was poured through a sieve at the top of the tower, with the tiny droplets forming perfect spheres during the fall; these were then cooled in a vat of water at the base. This process was less labor intensive than an earlier method using molds. It is the oldest of the three remaining shot towers in the UK.

Question 1: Using the parked van at the base, estimate …

Analysis Of Localization Algorithms For Wireless Sensor Networks Using Binary Data, Alexander Joseph Hart

Graduate Research Theses & Dissertations

The detection, localization, and tracking of environmental and physical conditions can be accomplished using wireless sensor networks (WSNs). Recent advancements in sensors, processors, and wireless communications have improved the quality and acquisition speed of data in WSNs. However, the data gathered by a WSN is inherently random due to component and environmental variations. Thus, statistical signal processing algorithms are needed to analyze the random data in a robust way. Though many algorithms for the analysis of random data are established and available, they are problem-specific and must be adapted to the application. This thesis provides an analysis of established localization …

Effects Of Slip On Highly Viscous Thin-Film Flows Inside Vertical Tubes (Constant Radius, Constricted And Flexible), Mark S. Schwitzerlett

Theses and Dissertations

Viscous liquid film flows in a tube arise in numerous industrial and biological applications, including the transport of mucus in human airways. Previous modeling studies have typically used no-slip boundary conditions, but in some applications the effects of slip at the boundary may not be negligible. We derive a long-wave model based on lubrication theory which allows for slippage along the boundary. Linear stability analysis verifies the impact of slip-length on the speed, growth rate, and wavelength of the most unstable mode. Nonlinear simulations demonstrate the impact of slip-length on plug formation and wave dynamics. These simulations are conducted for …

Spotting K-Tricaps In Spot It!, Jenarah Skyara Lara

Senior Projects Spring 2023

The card game “SPOT IT!” consists of 55 cards, with 8 symbols appearing on each card. Every pair of cards has exactly one symbol in common, and the goal of the game is to be the first person to find this symbol. An alternate way to play the game is to find sets of 3 cards that have the same symbol in common. We will use combinatorics, probability, and finite projective geometry to analyze the structure of the game. The game “SPOT IT!” can be viewed as the projective plane of order 7. However, we can construct a similar game …

The Power Of Supercomputing Applied To Fractal Image Generation, Charlin Me Duff

Mathematics Senior Capstones

This project looks into how parallelism benefits the runtime of generating large fractal images. First, it explains what the Julia and Mandelbrot Sets are, who discovered them, and how they are calculated. Following that is an introduction to supercomputers, parallel computing, and Cal Poly Humboldt’s very own supercomputer. Once groundwork is laid, I explain my process of adapting a fractal image generation program from serial computing to different levels of parallelism. After that, is an analysis of the effects of levels of parallelism on the runtime of large fractal image generation. This paper concludes with a reflection on the project …

Early Termination In Phase Ii Clinical Trials: Admissible Designs Using Decreasingly Informative Priors, Chen Wang

Theses and Dissertations

In Phase II clinical trials, Thall and Simon’s Bayesian posterior probability design is commonly implemented to allow for an early termination to determine whether a new treatment warrants further investigation in a larger-scale Phase III trial; this in turn requires a pre-selected prior distribution based on known clinical opinion or historical information. Moreover, this Bayesian approach can result in an issue of inflating type I error rate by monitoring interim data to inform early termination decisions. Alternatively, a Bayesian approach with the decreasingly informative prior (DIP), which is an informative yet skeptical prior, can be implemented to overcome the contentious …

Swarm Intelligence For Solving Some Nonlinear Differential Equations, Ahmed Elzaghal, Mohammed Mohammed Elgamal, Ahmed H. Eltanboly

Mansoura Engineering Journal

The Euler method is a well-known numerical technique employed for solving initial value problems of ordinary differential equations. The solution obtained through Euler's method is subject to significant inaccuracies, which tend to amplify with each successive iteration. The Particle Swarm Optimization (PSO) algorithm is a highly effective method for finding optimal solutions to both linear and nonlinear optimization problems. In this particular investigation, the PSO technique was utilized to solve initial value problems associated with ordinary differential equations. The Euler method, on the other hand, employs equidistant grid points to approximate solutions, which can result in significant errors and a …

Modeling Vascular Diffusion Of Oxygen In Breast Cancer, Tina Giorgadze

Senior Projects Spring 2023

Oxygen is a vital nutrient necessary for tumor cells to survive and proliferate. Oxygen is diffused from our blood vessels into the tissue, where it is consumed by our cells. This process can be modeled by partial differential equations with sinks and sources. This project focuses on adding an oxygen diffusion module to an existing 3D agent-based model of breast cancer developed in Dr. Norton’s lab. The mathematical diffusion module added to an existing agent-based model (ABM) includes deriving the 1-dimensional and multi-dimensional diffusion equations, implementing 2D and 3D oxygen diffusion models into the ABM, and numerically evaluating those equations …

Modeling Oyster Growth Dynamics In Flupsy Systems To Develop A Decision Support Tool For Seed Management, Gretchen Clauss

Honors Projects

As the Gulf of Maine warms and lobsters move north to colder waters, Maine’s working water front has begun to diversify. There is a thriving new ecosystem of aquaculturists looking to keep Maine’s waterfront traditions alive in a lasting, sustainable way. One of the most popular aquaculture industries is oyster farming. With an increasing number of oyster farms developing in Midcoast Maine each year, we seek to develop a decision support tool to aid farmers in seed management. Oyster farmers can choose weather or not to use an upweller on their farm, and our goal is to provide guidance on …

Computational Models Of Extracellular Matrix Remodeling In Pulmonary Fibrosis, Dylan Tyler Casey

Graduate College Dissertations and Theses

Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive and ultimately fatal interstitial lung disease of unknown etiology. Like most forms of fibrosis, it is thought to reflect an error in the homeostatic wound healing process, leading to excess scar tissue that impairs lung function. With few effective treatments, uncovering the pathogenesis of IPF may provide crucial information for improving outcomes. However, its elusive origin makes research with traditional methods in biology, such as cell and animal models, challenging. Here, we employ computational models to simulate the development of IPF and investigate mechanisms by which the disease begins and progresses.

IPF …

Bayesian Experimental Design For Control And Surveillance In Epidemiology, Bren Case

Graduate College Dissertations and Theses

Effective public health interventions must balance an array of interconnected challenges, and decisions must be made based on scientific evidence from existing information. Building evidence requires extrapolating from limited data using models. But when data are insufficient, it is important to recognize the limitations of model predictions and diagnose how they can be improved. This dissertation shows how principles from Bayesian experimental design can be applied to surveillance and control efforts to allow researchers to get more out of their data and direct limited resources to best effect. We argue a Bayesian perspective on data gathering, where design decisions are …

Clusters, Curves, And Centroids: Stellar Flare Morphology In The Ultraviolet, Vera Berger

Pomona Senior Theses

With a novel sample of 495 high-cadence light curves for stellar flares in the near-ultraviolet, I explore similarity measures, clustering algorithms, averaging methods, and curve fitting techniques for time series. This work seeks to provide insight into whether stellar flares are similar across stars, if we can identify physically meaningful patterns in their light curves, and how to construct a comprehensive model for flares. I construct the first empirical template for flare light curves in the ultraviolet, and compute ``average elements" of flares displaying complex features such as quasi-periodic oscillations and multipeak structures. Developing accurate models for flares in the …

The Lie Algebra Sl2(C) And Krawtchouk Polynomials, Nkosi Alexander

UNF Graduate Theses and Dissertations

The Lie algebra L = sl2(C) consists of the 2 × 2 complex matrices that have trace zero, together with the Lie bracket [y, z] = yz − zy. In this thesis we study a relationship between L and Krawtchouk polynomials. We consider a type of element in L said to be normalized semisimple. Let a, a^∗ be normalized semisimple elements that generate L. We show that a, a^∗ satisfy a pair of relations, called the Askey-Wilson relations. For a positive integer N, we consider an (N + 1)-dimensional irreducible L-module V consisting of the homogeneous polynomials in two variables …

Measuring Racial Segregation In Los Angeles County Using Random Walks, Zarina Kismet Dhillon

CMC Senior Theses

As of now there is no universal quantitative measure used to evaluate racial segregation in different regions. This paper begins by providing a history of segregation, with an emphasis on the impact of redlining in the early 20th century. We move to its effect on the current population distribution in Los Angeles, California, and then provide an overview of the mathematical concepts that have been used in previous measurements of segregation. We then introduce a method that we believe encompasses the most representative aspects of preceding work, proposed by Sousa and Nicosia in their work on quantifying ethnic segregation in …

Counting Spanning Trees On Triangular Lattices, Angie Wang

CMC Senior Theses

This thesis focuses on finding spanning tree counts for triangular lattices and other planar graphs comprised of triangular faces. This topic has applications in redistricting: many proposed algorithmic methods for detecting gerrymandering involve spanning trees, and graphs representing states/regions are often triangulated. First, we present and prove Kirchhoff’s Matrix Tree Theorem, a well known formula for computing the number of spanning trees of a multigraph. Then, we use combinatorial methods to find spanning tree counts for chains of triangles and 3 × n triangular lattices (some limiting formulas exist, but they rely on higher level mathematics). For a chain of …

Multipatch Stochastic Epidemic Model For The Dynamics Of A Tick-Borne Disease, Milliward Maliyoni, Holly D. Gaff, Keshlan S. Govinder, Faraimunashe Chirove

Biological Sciences Faculty Publications

Spatial heterogeneity and migration of hosts and ticks have an impact on the spread, extinction and persistence of tick-borne diseases. In this paper, we investigate the impact of between-patch migration of white-tailed deer and lone star ticks on the dynamics of a tick-borne disease with regard to disease extinction and persistence using a system of Itô stochastic differential equations model. It is shown that the disease-free equilibrium exists and is unique. The general formula for computing the basic reproduction number for all patches is derived. We show that for patches in isolation, the basic reproduction number is equal to the …

Dynamic Function Learning Through Control Of Ensemble Systems, Wei Zhang, Vignesh Narayanan, Jr-Shin Li

Publications

Learning tasks involving function approximation are preva- lent in numerous domains of science and engineering. The underlying idea is to design a learning algorithm that gener- ates a sequence of functions converging to the desired target function with arbitrary accuracy by using the available data samples. In this paper, we present a novel interpretation of iterative function learning through the lens of ensemble dy- namical systems, with an emphasis on establishing the equiv- alence between convergence of function learning algorithms and asymptotic behavior of ensemble systems. In particular, given a set of observation data in a function learning task, we …

Novel Architectures And Optimization Algorithms For Training Neural Networks And Applications, Vasily I. Zadorozhnyy

Theses and Dissertations--Mathematics

The two main areas of Deep Learning are Unsupervised and Supervised Learning. Unsupervised Learning studies a class of data processing problems in which only descriptions of objects are known, without label information. Generative Adversarial Networks (GANs) have become among the most widely used unsupervised neural net models. GAN combines two neural nets, generative and discriminative, that work simultaneously. We introduce a new family of discriminator loss functions that adopts a weighted sum of real and fake parts, which we call adaptive weighted loss functions. Using the gradient information, we can adaptively choose weights to train a discriminator in the direction …

Application Of The Two-Variable Model To Simulate A Multisensory Reaction-Time Task, Rebecca Brady, John Butler

Academic Posters Collection

To navigate the world in an efficient manner, the brain seamlessly integrates signals received across multiple sensory modalities. Behavioral studies have suggested that multisensory processing is a winner-take-all sensory response mechanism to some optimal combination of sensory signals. In addition, multiple sensory cues are not always beneficial with some studies showing maladaptive multisensory processing as an identifier of older adults prone to falls from age matched healthy controls.

A stalwart of modelling sensory decision-making is the work by (Wong &Wang, 2006) but to date almost all of this research has been focused on unisensory tasks. We extend the reduced two-variable …