Open Access. Powered by Scholars. Published by Universities.®

Physical Sciences and Mathematics Commons™

Open Access. Powered by Scholars. Published by Universities.®

Chemistry

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 1381 - 1410 of 34525

Full-Text Articles in Physical Sciences and Mathematics

Modeling Accuracy Matters: Aligning Molecular Dynamics With 2d Nmr Derived Noe Restraints, Milan Patel May 2023

Modeling Accuracy Matters: Aligning Molecular Dynamics With 2d Nmr Derived Noe Restraints, Milan Patel

Honors Scholar Theses

Among structural biology techniques, Nuclear Magnetic Resonance (NMR) provides a holistic view of structure that is close to protein structure in situ. Namely, NMR imaging allows for the solution state of the protein to be observed, derived from Nuclear Overhauser Effect restraints (NOEs). NOEs are a distance range in which hydrogen pairs are observed to stay within range of, and therefore experimental data which computational models can be compared against. To that end, we investigated the effects of adding the NOE restraints as distance restraints in Molecular Dynamics (MD) simulations on the 24 residue HP24stab derived villin headpiece subdomain to …

Go to article

Development And Study Of Small Database For The Activation Of Nitrous Oxide Towards Formation Of Iron(Iv)-Oxo Species, Tobias Barthalomew Robertson May 2023

Development And Study Of Small Database For The Activation Of Nitrous Oxide Towards Formation Of Iron(Iv)-Oxo Species, Tobias Barthalomew Robertson

Masters Theses

Nitrous oxide (N2O) can undergo an oxygen atom transfer (OAT) reaction resulting in inert nitrogen gas (N2O) while transferring an oxygen atom to a molecular complex or material. This process is of catalytic importance since this OAT reaction can be leveraged to form iron(IV)-oxo sites, which are known to be catalytic intermediates. Here, an investigation of the ligand field effects on primarily iron(II) complexes for the formation of iron(IV)-oxo sites with nitrous oxide as the oxidant is reported. An initial database of sixty-four molecular complexes with ligand environments varying in field strength and coordination geometry was …

Go to article

Understanding The Polymerization Of Ethyl Cyanoacrylate In The Superglue Fuming Of Latent Prints To Optimize Print Retrieval, Leondra Shawntae Lawson May 2023

Understanding The Polymerization Of Ethyl Cyanoacrylate In The Superglue Fuming Of Latent Prints To Optimize Print Retrieval, Leondra Shawntae Lawson

Masters Theses

The cyanoacrylate fuming method (CFM) is a widespread process used in forensics to make latent prints visible for detection, acquisition, and analysis. CFM is governed by the reaction of ethyl cyanoacrylate (ECA) with biological components in fingerprints, which serve as initiators for this anionic polymerization. CFM is not a well-controlled polymerization and there are different outcomes that may result from lower temperature, one of which fits the generalization of creating more ion-pair initiators. Another effect could be minimizing termination through suppressing side reactions. Alternatively, when paired with humidity, lower temperatures may cause surface condensation, decreasing the quality of the print. …

Go to article

Impact Of Cover Crop Species Diversity On Soil Nutrient Availability And Crop Productivity, Amanda Kramer May 2023

Impact Of Cover Crop Species Diversity On Soil Nutrient Availability And Crop Productivity, Amanda Kramer

Masters Theses

Cover crops provide multiple environmental benefits that improve both soil and water quality; however, farmers only utilize them on approximately 5% of harvested U.S. cropland. Low adoption rates are attributed to yield impact concerns, seed and planting costs, and lack of advocacy. This study, which began in October 2019, assessed the effects of nitrogen rate and cover crop diversity on weed biomass, soil coverage, in-situ residue decomposition, soil nitrogen and phosphorus availability, and cash crop yield to better understand the costs and benefits of cover crop adoption at two locations in Tennessee (Milan and Spring Hill). Treatments were replicated 4 …

Go to article

Design And Synthesis Of Peripherally Selective Endocannabinoid Enzyme Inhibitors For Ocular Indications, Kezia Reji Thomas May 2023

Design And Synthesis Of Peripherally Selective Endocannabinoid Enzyme Inhibitors For Ocular Indications, Kezia Reji Thomas

Senior Honors Theses

Peripherally selective compounds have been found to stimulate endocannabinoid receptor activity, which has been observed to have positive physiological effects such as ocular wound healing and inflammation control. The activation of the cannabinoid 1 receptor via binding of the endogenous ligands, anandamide and 2-arachidonoylglycerol, has been indicated to elicit these effects. Both ligands are controlled by two hydrolase enzymes, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), which can be targeted for therapeutic inhibition. Sulfonamide derivatives of JZL195 containing carbamate functionalities in the southern region of the inhibitor compounds were produced using novel carbamate exchange reactions. Polar functionalities were …

Go to article

Design And Synthesis Of Novel Peptide-Metal Organic Frameworks, Moustafa Mahmoud Abdel Wahid Hamaad May 2023

Design And Synthesis Of Novel Peptide-Metal Organic Frameworks, Moustafa Mahmoud Abdel Wahid Hamaad

Theses and Dissertations

Metal-organic frameworks (MOFs) are a class of crystalline porous materials with extended network structures formed through the reticular assembly of inorganic and organic molecular building blocks through strong coordination bonds. Compared to other porous materials, MOFs offer a high degree of structural diversity as their shape and pore size as well as functionality can tuned by the precise selection and design of their metal centers and organic struts. Due to their high surface areas, pore volumes, and the possibility of introduction of a myriad of chemical functionalities in their structures, MOFs have gained popularity for applications in many fields such …

Go to article

Anti-Doping Crisis In Sports, What's Next? Ion Mobility-Mass Spectrometry For The Study Of Anabolic Androgenic Steroids, Diana Constanza Velosa May 2023

Anti-Doping Crisis In Sports, What's Next? Ion Mobility-Mass Spectrometry For The Study Of Anabolic Androgenic Steroids, Diana Constanza Velosa

Theses and Dissertations

The main objective of this work is to augment both qualitative and quantitative measures of anabolic androgenic steroids (AAS) with ion mobility-mass spectrometry (IM-MS), laying the foundation for implementation into analytical drug testing laboratories. AAS testing requires high sensitivity and specificity. IM-MS is presented as an emerging technology workflow capable of targeted quantification of AAS and structural elucidation for potential unknowns, allowing ions to be separated and characterized based on their rotationally averaged collision cross section (CCS). Chapter 1 provides a background of the basic principles of IMS and the different types of analytical methods used for doping analysis currently …

Go to article

Separating The R Vs. S Enantiomers Of A Quinoline Aimed At Inhibiting The Allosteric Binding Pocket Of Hiv-1 Integrase, Madison Canfield May 2023

Separating The R Vs. S Enantiomers Of A Quinoline Aimed At Inhibiting The Allosteric Binding Pocket Of Hiv-1 Integrase, Madison Canfield

Honors Theses

HIV-1 is a retroviral disease that infects CD4+ T cells in the body. Once inside the body, HIV-1 uses human cell machinery to replicate and reproduce using several enzymes to reverse transcribe viral RNA to DNA and integrate the viral DNA into the human genome to reproduce. Several drugs, such as NRTIs, INSTIs, NNRTIs, and PIs, have been created to inhibit specific parts of the viral life cycle and are used in combination to fight HIV-1. However, these medications face challenges of viral mutation and resistance, which increases the importance of creating more potent and effective drugs. Recently, a new …

Go to article

Analysis Of Steroid Hormone Isomers Using Ion Mobility-Mass Spectrometry, Shon Paul Neal May 2023

Analysis Of Steroid Hormone Isomers Using Ion Mobility-Mass Spectrometry, Shon Paul Neal

Theses and Dissertations

This dissertation presents a comprehensive study on the analysis of steroid hormone isomers using liquid chromatography-ion mobility-mass spectrometry (LC-IM-MS). The dissertation is divided into three main parts: the first part focuses on research using different drift gases and ion adducts to modify the mobility separations allowing for resolution between the isomers. The second part focuses on research exploring derivatization reactions that target structural differences between the steroid hormone isomers to amplify the differences and resolve the isomers in the ion mobility region. The final part covers a proposal on future study directions to include simultaneous derivatization reactions, mass spectrometry fragmentation, …

Go to article

1. Influence Of Metal Ions And Solvents On The Photo-Generation Of Reactive Oxygen Species In Mesoporous Silicate Embedded Porphyrins 2.Water-Soluble Rhodium(Iii) Porphyrin Complex For The Biological Inactivation Of Fentanyl, Hemant Pal May 2023

1. Influence Of Metal Ions And Solvents On The Photo-Generation Of Reactive Oxygen Species In Mesoporous Silicate Embedded Porphyrins 2.Water-Soluble Rhodium(Iii) Porphyrin Complex For The Biological Inactivation Of Fentanyl, Hemant Pal

Theses and Dissertations

Porphyrins are differentiated π-conjugated compounds with unique photochemical and redox properties. The tetrapyrrole macrocycle core of porphyrins is extremely favorable for the complexation of metal ions, resulting in hybrid metal-organic molecules with good catalytic properties. Porphyrin-based systems are known for their oxidative properties and are frequently utilized as bio-mimicking catalysts and environmental remediation agents. My current research aims at both of these aspects. One of the most efficient methods to create photocatalytic systems with outstanding features and applicability is the use of porphyrins on supported solid materials. A series of novel mesoporous silicate-embedded metalloporphyrins were prepared via conjugation of novel …

Go to article

Water-Soluble Iron Porphyrin Complex For The Catalytic N-Dealkylation Of Fentanyl, Amanda Pitt May 2023

Water-Soluble Iron Porphyrin Complex For The Catalytic N-Dealkylation Of Fentanyl, Amanda Pitt

Theses and Dissertations

An increase in the misuse of opioids in the United States and the increasing potency of analogs necessitates novel treatments of opioid overdose. The chemical structure of synthetic opioids, such as fentanyl, carfentanil, and morphine possess a trialkyl amine functional group (-NR3) which makes for a promising target for potential catalysts. Iron (III)-tetrasulfonatophenyl porphyrin (complex 9) was synthesized as a potential catalyst for degradation of fentanyl. Complex 9a was prepared from the direct reaction of the free porphyrin and FeSO4. Complex 9b was prepared from the direct reaction of the free porphyrin and FeCl2 in refluxing DMF. The complexes were …

Go to article

Mechanisms Of Formation Of Novel Guanine-Guanine Cross-Links As Major End Products During One-Electron Oxidation Of Guanine Derivatives, Evan Dunn May 2023

Mechanisms Of Formation Of Novel Guanine-Guanine Cross-Links As Major End Products During One-Electron Oxidation Of Guanine Derivatives, Evan Dunn

Undergraduate Honors Theses

Guanine (G), as the most oxidizable base in DNA, is the major focus of studies of oxidation damage to DNA. The present thesis reports the first detailed characterization of G dimerization products potentially resulting from recombination of neutral G• radicals. Previous research has discovered a novel type of products of G• dimerization, D1 and D2, formed from one-electron oxidation of G derivatives. However, the mechanism of this dimerization remains elusive. While there appears to be a tautomeric equilibrium between two forms of G•, G(N1-H)• or G(N2-H)•, it remains unclear which intermediate participates in the formation of …

Go to article

Studies Of The Reaction Of Rongalite With Epoxides, Anuj Aryal May 2023

Studies Of The Reaction Of Rongalite With Epoxides, Anuj Aryal

Theses, Dissertations and Culminating Projects

Reactions between Rongalite (Na+O-SOCH2OH) and epoxides were studied with the aim of developing new synthetic routes for the procurement of sulfone diols. This class of compounds contains essential building blocks in the construction of sulfur heterocycles, which have been implied in the development of several medicinal compounds. Thus far, the desired diols have not been isolated. During control experiments with bromo alcohols, an unknown product was isolated but remains to be identified.

Go to article

Nb3Sn Coating Of Twin Axis Cavity And Other Complex Srf Cavity Structures, Jayendrika Kumari Tiskumara May 2023

Nb3Sn Coating Of Twin Axis Cavity And Other Complex Srf Cavity Structures, Jayendrika Kumari Tiskumara

Physics Theses & Dissertations

In the field of Accelerator Science, for the low cost and increased quality factor, thin films coated niobium cavities are used in the modern SRF research. Within the potential substances, Nb3Sn has shown higher critical temperature than niobium. Here the tin vapor diffusion method is used as the preferred technique to coat niobium cavities. So far, only elliptical cavities have been coated with Nb3Sn and this technique has not yet been applied to cavities with complex geometries, which are also helpful in the accelerator science field. The Half-wave resonator could provide us data across frequencies of …

Go to article

Spectroscopic Studies On Silicon And Chalcopyrite Materials For Solar Energy Applications, Amandee Hua May 2023

Spectroscopic Studies On Silicon And Chalcopyrite Materials For Solar Energy Applications, Amandee Hua

UNLV Theses, Dissertations, Professional Papers, and Capstones

In this dissertation, silicon-based materials for photovoltaics and chalcopyrite-based materials for photoelectrochemical water splitting are investigated using various spectroscopic and microscopic techniques. Although silicon dominates the photovoltaic market, further improvement can be made by using an alternative low temperature passivation approach. Currently, thermally grown SiO2 passivation is commonly used for silicon solar cells. However, this technique requires high processing temperatures (>800 °C), which increases the thermal budget, potentially decreases the bulk quality of Si, and can lead to difficulties in implementing in production lines. Here, a S-based passivation approach is studied that require lower processing temperatures of ~550 °C. …

Go to article

Collisional Excitation Of C2h- By H2: New Interaction Potential And Scattering Calculations, Fabien Dumouchel, Ernesto Quintas-Sánchez, Christian Balança, Richard Dawes, François Lique, Nicole Feautrier Apr 2023

Collisional Excitation Of C2h- By H2: New Interaction Potential And Scattering Calculations, Fabien Dumouchel, Ernesto Quintas-Sánchez, Christian Balança, Richard Dawes, François Lique, Nicole Feautrier

Chemistry Faculty Research & Creative Works

Interstellar Anions Play an Important Role in Astrochemistry as Being Tracers of the Physical and Chemical Conditions in Cold Molecular Clouds and Circumstellar Gas. the Local Thermodynamic Equilibrium is Generally Not Fulfilled in Media Where Anions Are Detected and Radiative and Collisional Data Are Required to Model the Observed Lines. the C2H- Anion Has Not Yet Been Detected in the Interstellar Medium; However, Collisional Data Could Be Used for Non-LTE Models that Would Help in Identifying the Most Intense Lines. for This Purpose, We Have Computed the First 4D Potential Energy Surface (PES) of the C2H--H2 Complex using an Explicitly …

Go to article

Synthesis Of 2-Bromo-6-Alkylaminopyridines, 2,6-Dialkylaminopyridines, And Tren Based Ligands, Stephanie E. Carter Apr 2023

Synthesis Of 2-Bromo-6-Alkylaminopyridines, 2,6-Dialkylaminopyridines, And Tren Based Ligands, Stephanie E. Carter

Honors College Theses

Extended metal atom chains (EMAC) are multimetallic complexes that feature a linear metal chain with metal-metal bonds surrounded by stabilizing ligand molecules. When EMACs are formed with paramagnetic metal ions, unique magnetic properties can be derived from direct metal to metal communication. The challenge is that EMAC complexes are challenging to synthesize due to the inherent weakness of most M-M bonds and the specificity of the ligands required to stabilize EMACs. In prior work by the Guillet group, the silyl aminopyridine (SAP) ligands were observed to stabilize very unique triiron complexes, but they were inherently unstable. In other work, scaffolded …

Go to article

Preface To The Special Issue On Lithium-Sulfur Batteries, Jia-Jia Chen, Ren-Jie Chen, Zhong Jin Apr 2023

Preface To The Special Issue On Lithium-Sulfur Batteries, Jia-Jia Chen, Ren-Jie Chen, Zhong Jin

Journal of Electrochemistry

No abstract provided.

Go to article

Synthesis And Characterization Of Rhenium 2,2′-Pyridylnaphthyridine Metal Complexes, Benjamin F. Solomon Apr 2023

Synthesis And Characterization Of Rhenium 2,2′-Pyridylnaphthyridine Metal Complexes, Benjamin F. Solomon

Honors Theses

Rhenium (Re) is a group 7 heavy 5d transition metal in the same family as manganese (Mn) and technetium (Tc). Re-carbonyl complexes are known to be catalysts for many different kinds of reactions from C-C bond formation to reduction reactions like CO2 reduction (CO2RR)1,2. With this in mind, we have prepared a set of six Re-carbonyl complexes of 2,2′-pyridyl-1,6-naphthyridine (1,6- pynap) and 2,2′-pyridyl-1,8-naphthyridine (1,8-pynap), a redox non-innocent ligand containing a bpy moiety as well as an additional aryl nitrogen binding location at which another metal-ligand bond could form. We have synthesized these complexes as precursors …

Go to article

Recent Advances Of Functional Electrolyte Additives For Lithium-Sulfur Batteries, Xiu-Qing Zhang, Shuai Tang, Yong-Zhu Fu Apr 2023

Recent Advances Of Functional Electrolyte Additives For Lithium-Sulfur Batteries, Xiu-Qing Zhang, Shuai Tang, Yong-Zhu Fu

Journal of Electrochemistry

Lithium-sulfur (Li-S) batteries have become one of the most promising next-generation battery systems due to their high energy density and low cost. However, the application of Li-S batteries still faces critical challenges, such as the low conductivities of S and Li2S, shuttle effect of polysulfides and dendrite growth of Li, etc. The optimization of the electrolyte can ameliorate the electrolyte|electrode interphase, conveniently regulating the parasitic reaction and improving the performance of the resultant batteries. The functional additives in electrolytes provide chances to tune the interphase and even the redox mechanism to improve the performance of the batteries. In …

Go to article

Metals And Alloys As Catalytic Hosts Of Sulfur Cathode For Lithium-Sulfur Batteries, Zhen-Yu Wang, Xue-Ping Gao Apr 2023

Metals And Alloys As Catalytic Hosts Of Sulfur Cathode For Lithium-Sulfur Batteries, Zhen-Yu Wang, Xue-Ping Gao

Journal of Electrochemistry

Lithium-sulfur batteries are recognized as one of the most promising next-generation energy storage devices, owing to the high theoretical energy density of 2600 Wh·kg–1. However, their application has been seriously hindered by the sluggish electrochemical reaction kinetics of elemental sulfur and discharged products (Li2S2/Li2S), and the notorious “shuttle effect” of soluble intermediate lithium polysulfide species, leading to poor cycle stability, low sulfur utilization and inferior coulombic efficiency. Introducing catalytic hosts into sulfur cathode is an efficient path to propel the conversion of sulfur-contained species, thus preventing the dissolution and loss of active-sulfur …

Go to article

Ultraviolet-Initiated In-Situ Cross-Linking Of Multifunctional Binder Backbones Enables Robust Lithium-Sulfur Batteries, Sha Li, Xiao Zhan, Gu-Lian Wang, Hui-Qun Wang, Wei-Ming Xiong, Li Zhang Apr 2023

Ultraviolet-Initiated In-Situ Cross-Linking Of Multifunctional Binder Backbones Enables Robust Lithium-Sulfur Batteries, Sha Li, Xiao Zhan, Gu-Lian Wang, Hui-Qun Wang, Wei-Ming Xiong, Li Zhang

Journal of Electrochemistry

Lithium-sulfur (Li-S) batteries show attractive prospects owing to their high theoretical energy density, but their commercialization still faces such challenges as lithium polysulfides shuttling, severe volume change and considerable polarization. These stubborn issues place higher demands on each component in the battery, such as the development of multifunctional binders with superior mechanical properties. Herein, ethoxylated trimethylolpropane triacrylate was firstly introduced into sulfur cathodes, and in-situ cross-linked by ultraviolet (UV) curing combined with traditional polyvinylidene difluoride binder (i.e., forming a binary binder, denoted as c-ETPTA/PVDF) to construct high-loading and durable Li-S batteries. The covalently cross-linked ETPTA framework not …

Go to article

Cobalt/Carbon Composites As Sulfur Hosts For High-Performance Lithium-Sulfur Batteries, Yun-Rui Yang, Huan-Huan Dong, Zhi-Qiang Hao, Xiang-Xi He, Zhuo Yang, Lin Li, Shu-Lei Chou Apr 2023

Cobalt/Carbon Composites As Sulfur Hosts For High-Performance Lithium-Sulfur Batteries, Yun-Rui Yang, Huan-Huan Dong, Zhi-Qiang Hao, Xiang-Xi He, Zhuo Yang, Lin Li, Shu-Lei Chou

Journal of Electrochemistry

Lithium-sulfur (Li-S) battery is one of the promising energy storage devices because of its high energy density. However, the sulfur cathode suffers from sluggish electrochemical reaction kinetics, slow charge transfer, large volume expansion and severe shuttle effect of lithium polysulfides inevitably resulting in low reversible capacity, poor rate performance and short cycle life, limiting its practical applications. Herein, the recent progress of cobalt/carbon composites, including cobalt nanoparticles and cobalt single atoms, as the sulfur host materials in Li-S batteries is overviewed. In general, cobalt plays the role of electrocatalyst, which inhibits the shuttle effect of lithium polysulfides, accelerates the electrochemical …

Go to article

Synthesis And Evaluation Of 1-Substituted Imidazo[4,5-C] Quinoline Tlr7 Agonists With Improved Potency, Emma Grace Deyoung Apr 2023

Synthesis And Evaluation Of 1-Substituted Imidazo[4,5-C] Quinoline Tlr7 Agonists With Improved Potency, Emma Grace Deyoung

Undergraduate Honors Theses

TLR7 agonists are small molecules that are useful within cancer immunotherapy due to their ability to stimulate the TLR7 pathway resulting in NFκB activation, and cytokine release.1 Due to the risk of toxicity when delivered systemically, our team has employed a particular type of drug-delivery technology, Antibody Drug Conjugates (ADCs) to deliver these payloads directly to tumor tissue. The initial focus of this work was on E104 (8a), an imidazoquinoline TLR7 agonist, which was synthesized by the Tumey lab.1 However, the agonist was not sufficiently potent for many of the proposed applications of this technology, prompting a need to develop …

Go to article

Protein Engineering Of A Fluorescent Watermelon Malate Dehydrogenase, William Yu Apr 2023

Protein Engineering Of A Fluorescent Watermelon Malate Dehydrogenase, William Yu

Celebrating Scholarship and Creativity Day (2018-)

Malate dehydrogenase (MDH) is an enzyme that is prevalent in many metabolic processes, such as the Krebs cycle and the citric acid cycle4. It reversibly forms oxaloacetate and NADH from (S)-malate and NAD+,1. Tryptophan fluorescence would be ideal to monitor conformational changes of MDH, but watermelon glycosomal MDH does not contain any tryptophan amino acids4. The research question being tested here is whether or not it is possible to mutate MDH to contain a tryptophan while still retaining native-like specific activity. This research question has not been addressed as a literature search has shown no research has been done to …

Go to article

Brown Carbon From Photo-Oxidation Of Glyoxal And So2 In Aqueous Aerosol, David O. De Haan, Lelia N. Hawkins, Praveen D. Wickremasinghe, Alyssa D. Andretta, Juliette R. Dignum, Audrey C. De Haan, Hannah G. Welsh, Elyse A. Pennington, Tianqu Cui, Jason D. Surratt, Mathieu Cazaunau, Edouard Pangui, Jean-François Doussin Apr 2023

Brown Carbon From Photo-Oxidation Of Glyoxal And So2 In Aqueous Aerosol, David O. De Haan, Lelia N. Hawkins, Praveen D. Wickremasinghe, Alyssa D. Andretta, Juliette R. Dignum, Audrey C. De Haan, Hannah G. Welsh, Elyse A. Pennington, Tianqu Cui, Jason D. Surratt, Mathieu Cazaunau, Edouard Pangui, Jean-François Doussin

Chemistry and Biochemistry: Faculty Scholarship

Aqueous-phase dark reactions during the co-oxidation of glyoxal and S(IV) were recently identified as a potential source of brown carbon (BrC). Here, we explore the effects of sunlight and oxidants on aqueous solutions of glyoxal and S(IV), and on aqueous aerosol exposed to glyoxal and SO2. We find that BrC is able to form in sunlit, bulk-phase, sulfite-containing solutions, albeit more slowly than in the dark. In more atmospherically relevant chamber experiments where suspended aqueous aerosol particles are exposed to gas-phase glyoxal and SO2, the formation of detectable amounts of BrC requires an OH radical source …

Go to article

The Role Of Sars-Cov-2 Orf8 Protein Arks Motif On Novobiocin Binding, Si Chun Chiu, My T. Nguyen Apr 2023

The Role Of Sars-Cov-2 Orf8 Protein Arks Motif On Novobiocin Binding, Si Chun Chiu, My T. Nguyen

Celebrating Scholarship and Creativity Day (2018-)

The discovery of the SARS-CoV-2 virus during the COVID-19 pandemic required scientists to develop medical solutions to reduce infectivity, severity of symptoms, and death. Although vaccines and drugs provided urgent assistance, the need to continue developing better drugs is necessary long term, and understanding the structure of the virus and finding potential inhibitors would prove vital to discovering solutions to this worldwide health problem. This experimental project focuses on targeting the unique accessory protein, Open Reading Frame 8 (ORF8) in SARS-CoV-2 through studying its interactions with a repurposable drug, novobiocin. Importantly, ORF8 specializes in helping evade immune system checks by …

Go to article

Chemically Responsive Hydrogels, Properties, Pharmaceuticals, And Agricultural Applications: A Review, Mohammad Alrbaihat, Qusay Abu-Afifeh, Firas Al-Zeidaneen Apr 2023

Chemically Responsive Hydrogels, Properties, Pharmaceuticals, And Agricultural Applications: A Review, Mohammad Alrbaihat, Qusay Abu-Afifeh, Firas Al-Zeidaneen

Al-Bahir Journal for Engineering and Pure Sciences

A review of the literature on chemically responsive hydrogels about the selection of selectivity based on classification, properties, and application is presented in this article. Chemically responsive hydrogels are a type of hydrogel that undergo changes in their properties in response to specific stimuli. These hydrogels have attracted significant attention due to their potential applications in various fields, including pharmaceuticals and agriculture. Chemically crosslinked hydrogels are synthesized by covalent crosslinking of end-functionalized macromeres. Currently, a great deal of research is being conducted on hydrogel networks, also known as smart networks or hungry networks. This is owing to their potential use …

Go to article

219 - Developing A Portable System Of Environmental Dna (Edna) Surveillance To Monitor Fish Population Dynamics And Detect Invasive Species In Conesus Lake And The Philippine Seas, Karina Mirza, Micah Ford, Morgan Comstock Apr 2023

219 - Developing A Portable System Of Environmental Dna (Edna) Surveillance To Monitor Fish Population Dynamics And Detect Invasive Species In Conesus Lake And The Philippine Seas, Karina Mirza, Micah Ford, Morgan Comstock

GREAT Day Posters

Climate change is an increasing threat to many ecosystems worldwide. Due to global warming, many species are under threat of extinction while others are forced into unusual patterns of migration. In the Philippines, the fish Round Scad is a cheap source of protein in the diet of common citizens. Alarmingly, it is rapidly declining in both population and body size. In this project, we aim to develop a cheap, rapid, and sensitive method of monitoring the population dynamics of this fish in the wild. Recently, a new method called environmental DNA (eDNA) metabarcoding has been developed as a cost-effective way …

Go to article

195 - Targeting Telomeric And C-Myc G4 Dna As An Anticancer Approach, Alexander Michaels, Sameela Haidari, Courtney Fetzer Apr 2023

195 - Targeting Telomeric And C-Myc G4 Dna As An Anticancer Approach, Alexander Michaels, Sameela Haidari, Courtney Fetzer

GREAT Day Posters

G-quadruplex (G4) DNA are non-canonical higher order DNA structures formed from guanine rich sequences, made up of stacked G-tetrads stabilized by non-Watson-Crick (Hoogsteen) base pairing and K+ ions. Early interests in G4 DNA were spurred on by the revelation that G4 was formed in telomeric DNA sequences at the end of our chromosomes. This was particularly promising given that G4 structures formed in telomeric DNA were also found to inhibit an enzyme known as telomerase, which is overexpressed (>90%) in cancer cells. Cancer cells require telomerase activity for survival and "immortality", therefore stabilization of telomeric G4 can inhibit …

Go to article

First Prev Next Last