Physical Sciences and Mathematics Commons^™

Assessment Of Her2-Neu In Breast Cancer Lines Upon Differential Exposures To Xenoestrogens, Abha Aggarwal

Walden Dissertations and Doctoral Studies

Synthetic xenoestrogens have differential estrogenic properties. Research has shown that exposures to xenoestrogens could promote breast cancer by disrupting normal function of the human epidermal growth factor receptor 2 (Her2) gene. Although animal models demonstrated a connection between xenoestrogen exposure and Her2 activity, no study using human cells has systematically examined their carcinogenic potential influencing the Her2 gene expression. Furthermore, breast cancer cells are phenotypically disparate (ER+, Her2+), with some phenotypes (Her2+), leading to more aggressive disease. This study aimed to dosimetrically assess the carcinogenic potential of commonly used xenoestrogens influencing Her2 gene expression, and delineate cellular phenotypes at greater …

A Comparison Between 2010 And 2006 Air Quality And Meteorological Conditions, And Emissions And Boundary Conditions Used In Simulations Of The Aqmeii-2 North American Domain, Till E. Stoeckenius, Christian Hogrefe, Justin Zagunis, Timonthy M. Sturtz, Benjamin Wells, Tanarit Sakulyanontvittaya

United States Environmental Protection Agency: Publications

Several participants in Phase 2 of the Air Quality Model Evaluation International Initiative (AQMEII-2) who are applying coupled models to the North American domain are comparing model results for two years, 2006 and 2010, with the goal of performing dynamic model evaluation. From a modeling perspective, the differences of interest are the large reductions in domain total emissions of NO_x (21%) and SO₂ (37%) from 2006 to 2010 and significant differences in meteorological conditions between these two years. The emission reductions occurred mostly in the eastern U.S, with some reduction in emissions from western wildfires in 2010. Differences …

Potential Aquifer Vulnerability In Regions Down-Gradient From Uranium In Situ Recovery (Isr) Sites, James A. Saunders, Bruce E. Pivetz, Nathan Voorhies, Richard T. Wilkin

United States Environmental Protection Agency: Publications

Sandstone-hosted roll-front uranium ore deposits originate when U(VI) dissolved in groundwater is reduced and precipitated as insoluble U(IV) minerals. Groundwater redox geochemistry, aqueous complexation, and solute migration are important in leaching uranium from source rocks and transporting it in low concentrations to a chemical redox interface where it is deposited in an ore zone typically containing the uranium minerals uraninite, pitchblende, and/or coffinite; various iron sulfides; native selenium; clays; and calcite. In situ recovery (ISR) of uranium ores is a process of contacting the uranium mineral deposit with leaching and oxidizing (lixiviant) fluids via injection of the lixiviant into wells …

Identification Of Putative Geographically Isolated Wetlands Of The Conterminous United States, Charles R. Lane, Ellen D'Amico

United States Environmental Protection Agency: Publications

Geographically isolated wetlands (GIWs) are wetlands completely surrounded by uplands. While common throughout the United States (U.S.), there have heretofore been no nationally available, spatially explicit estimates of GIW extent, complicating efforts to understand the myriad biogeochemical, hydrological, and habitat functions of GIWs and hampering conservation and management efforts at local, state, and national scales. We used a 10-m geospatial buffer as a proxy for hydrological or ecological connectivity of National Wetlands Inventory palustrine and lacustrine wetland systems to nationally mapped and available stream, river, and lake data. We identified over 8.3 million putative GIWs across the conterminous U.S., encompassing …

Alpha-Lipoic Acid Supplementation Protects Enzymes From Damage By Nitrosative And Oxidative Stress, Sylvia Hiller, Robert Dekroon, Eric D. Hamlett, Longquan Xu, Cristina Osorio, Jennifer Robinette, Witold Winnik, Stephen Simington, Nobuyo Maeda, Oscar Alzate, Xianwen Yi

United States Environmental Protection Agency: Publications

Background: S-nitrosylation of mitochondrial enzymes involved in energy transfer under nitrosative stress may result in ATP deficiency. We investigated whether α-lipoic acid, a powerful antioxidant, could alleviate nitrosative stress by regulating S-nitrosylation,which could result in retaining themitochondrial enzyme activity.

Methods: In this study, we have identified the S-nitrosylated forms of subunit 1 of dihydrolipoyllysine succinyltransferase (complex III), and subunit 2 of the α-ketoglutarate dehydrogenase complex by implementing a fluorescence-based differential quantitative proteomics method.

Results: We found that the activities of these two mitochondrial enzymes were partially but reversibly inhibited by S-nitrosylation in cultured endothelial cells, and that their activities …

Temporal Trends In The Spatial Distribution Of Impervious Cover Relative To Stream Location, J. Wickham, A. Neale, M. Mehaffey, T. Jarnagin, D. Norton

United States Environmental Protection Agency: Publications

Use of impervious cover is transitioning from an indicator of surface water condition to one that also guides and informs watershed planning and management, including Clean Water Act (33 U.S.C. §1251 et seq.) reporting. Whether it is for understanding surface water condition or planning and management, impervious cover is most commonly expressed as summary measurement (e.g., percentage watershed in impervious cover). We use the National Land Cover Database to estimate impervious cover in the vicinity of surface waters for three time periods (2001, 2006, 2011). We also compare impervious cover in the vicinity of surface waters to watershed summary estimates …

Estimating Ozone And Secondary Pm2.5 Impacts From Hypothetical Single Source Emissions In The Central And Eastern United States, Kirk R. Baker, Robert A. Kotchenruther, Rynda C. Hudman

United States Environmental Protection Agency: Publications

Secondary pollutant impacts from emissions of single sources may need to be assessed to satisfy a variety of regulatory requirements including the Clean Air Act New Source Review and Prevention of Significant Deterioration programs and the National Environmental Policy Act. In this work, single source impacts on O₃ and secondary PM_2.5 are estimated with annual 2011 photochemical grid model simulations where new hypothetical sources are added to the central and eastern United States with varying precursor emission rates and emission release heights. Impacts from these hypothetical sources are tracked with photochemical grid model source apportionment. Single source impacts …

Seasonality Of Coliform Bacteria Detection Rates In New Jersey Domestic Wells, Thomas B. Atherholt, Nicholas A. Procopio, Sandra M. Goodrow

United States Environmental Protection Agency: Publications

It is important that indicators of fecal pollution are reliable. Coliform bacteria are a commonly used indicator of fecal pollution. As other investigators have reported elsewhere, we observed a seasonal pattern of coliform bacteria detections in domestic wells in New Jersey. Examination of a statewide database of 10 years of water quality data from 93,447 samples, from 78,207 wells, generated during real estate transactions, revealed that coliform bacteria were detected in a higher proportion of wells during warm weather months. Further examination of the seasonal pattern of other data, including well water pH, precipitation, ground and surface water temperatures, surface …

Cyanotoxins In Inland Lakes Of The United States: Occurrence And Potential Recreational Health Risks In The Epa National Lakes Assessment 2007, Keith A. Loftin, Jennifer L. Graham, Elizabeth D. Hillborn, Sarah C. Lehmann, Michael T. Meyer, Julie E. Dietze, Christopher B. Griffith

United States Environmental Protection Agency: Publications

A large nation-wide survey of cyanotoxins (1161 lakes) in the United States (U.S.) was conducted during the EPA National Lakes Assessment 2007. Cyanotoxin data were compared with cyanobacteria abundance- and chlorophyll-based World Health Organization (WHO) thresholds and mouse toxicity data to evaluate potential recreational risks. Cylindrospermopsins, microcystins, and saxitoxins were detected (ELISA) in 4.0, 32, and 7.7% of samples with mean concentrations of 0.56, 3.0, and 0.061 mg/L, respectively (detections only). Co-occurrence of the three cyanotoxin classes was rare (0.32%) when at least one toxin was detected. Cyanobacteria were present and dominant in 98 and 76% of samples, respectively. Potential …

Water Consumption Estimates Of The Biodiesel Process In The Us, Qingshi Tu, Mingming Lu, Y. Jeffrey Yang, Don Scott

United States Environmental Protection Agency: Publications

As a renewable alternative to petroleum diesel, biodiesel has been widely used in the US and the world. However, its potential impact on water resources has not been much evaluated. This study investigates water consumption from the biodiesel process, which includes three stages: soybean irrigation, soybean-to-soybean oil processing, and biodiesel manufacturing, at both national and state levels. Mass-based allocation is performed and water consumption at the three stages is obtained on the basis of million gallons per year and gallon water per gallon biodiesel (gal/gal). The normalized water consumption (water intensity) of the irrigation, oil processing, and biodiesel production stages …

Carbon Storage In Us Wetlands, A. M. Nahlik, M. S. Fennessy

United States Environmental Protection Agency: Publications

Wetland soils contain some of the highest stores of soil carbon in the biosphere. However, there is little understanding of the quantity and distribution of carbon stored in our remaining wetlands or of the potential effects of human disturbance on these stocks. Here we use field data from the 2011 National Wetland Condition Assessment to provide unbiased estimates of soil carbon stocks for wetlands at regional and national scales. We find that wetlands in the conterminous United States store a total of 11.52 PgC, much of which is within soils deeper than 30 cm. Freshwater inland wetlands, in part due …

Quantitative Structure–Mesothelioma Potency Model Optimization For Complex Mixtures Of Elongated Particles In Rat Pleura: A Retrospective Study, Philip M. Cook, Joseph Swintek, Timothy D. Dawson, David Chapman, Mathew A. Etterson, Dale Hoff

United States Environmental Protection Agency: Publications

Cancer potencies of mineral and synthetic elongated particle mixtures, including asbestos fibers, are influenced by changes in fiber dose composition, bioavailability, and biodurability in combination with relevant cytotoxic dose-response relationships. An extensive rat intrapleural dose characterization data set with a wide variety of elongated particles physicochemical properties facilitated statistical analyses of pleural mesothelioma response data combined from several studies for evaluation of alternative dose-response models. Utilizing logistic regression of individual elongated particle dimensional variations within each test sample, four major findings emerged: (1) Mild acid leaching provides superior prediction of tumor incidence compared to samples that were not leached; (2) …

Nebraska Water Center Annual Report 2016, Nebraska Water Center

Nebraska Water Center: Literature

Contents

Foreword

Director’s Letter

Since 1964: The Nebraska Water Center

Building the future

Nebraska’s Top 10 water challenges

Nebraska Water Center advisory board

Water Resources Advisory Panel: A key to success

Nebraska Water Sciences Laboratory

USGS 104b projects for 2016

Ogallala Aquifer focus of USDA research grant

Graduate research on amphetamines draws attention

NIC hosts water symposium and law conference

Water seminar lectures key on “Water and health”

Four picked for IRES program in Czech Republic

WARI program begins

2016 tour to Colorado’s South Platte basin

45th annual tour visits Platte River basin in Colorado

McCornick new Water for Food …

Nebraska Water Center (Brochure ), Nebraska Water Center

Nebraska Water Center: Literature

The Nebraska Water Center was established in 1964 as one of 54 Water Resources Research Institutes nationwide with passage of the first Clean Water Act. It facilitates the University of Nebraska-Lincoln’s land grant missions in research, extension and teaching in water science, law and policy to address water quantity and quality issues of priority to Nebraska. NWC helps water researchers by awarding small grants, conducting water-related education and outreach activities for stakeholders, and disseminating research results through media, colloquia, conferences, lectures, and tours. NWC provides state-of-the-art analytical technology to conduct water research and education to scientists and engineers, helping them …

2016 Nebraska Water Monitoring Programs Report, Marty Link, Ryan Chapman

Nebraska Department of Environmental Quality: Reports

The Nebraska Department of Environmental Quality (NDEQ) is charged with monitoring, assessing, and to the extent possible, managing the state’s water resources. The purpose of this work is to protect and maintain high quality water and encourage or execute activities to improve poor water quality. Monitoring is done on nearly 17,000 miles of flowing rivers and streams, more than 134,000 acres of surface water in lakes and reservoirs, as well as the vast storage of groundwater in Nebraska’s aquifers.

2016 Nebraska Groundwater Quality Monitoring Report

Nebraska Department of Environmental Quality: Reports

The 2001 Nebraska Legislature passed LB329 (Neb. Rev. Stat. §46-1304) which, in part, directed the Nebraska Department of Environmental Quality (NDEQ) to report on groundwater quality monitoring in Nebraska. Reports have been issued annually since December 2001. The text of the statute applicable to this report follows: “The Department of Environmental Quality shall prepare a report outlining the extent of ground water quality monitoring conducted by natural resources districts during the preceding calendar year. The department shall analyze the data collected for the purpose of determining whether or not ground water quality is degrading or improving and shall present the …

Non-Point Sources And Point Sources For Nutrient And Fecal Microbe Contamination In A Typical Upland Stream: Tates Creek, Madison County, Kentucky, Walter S. Borowski, Malcolm P. Frisbie

EKU Faculty and Staff Scholarship

Tates Creek (Madison County, Kentucky) is characterized by an oversupply of nutrients and fecal microbe contamination. Its watershed is dominated by pastureland and immature woodlands with scattered settlements served by septic systems, whereas, 5% of the watershed drains urban areas of Richmond, Kentucky. Creek waters are eutrophic and commonly display levels of Escherichia coli deemed unfit for human contact by United States Environmental Protection Agency standards. Both point and non-point sources existed for stream contaminants. A secondary sewage treatment plant (STP) discharged effluent into the creek until mid-2011 and was a point source for nitrate and phosphate. Pastureland likely contributes …

Potential Effects Of Chemical Contamination On South Florida Bonefish Albula Vulpes, Christine P. Beck

FIU Electronic Theses and Dissertations

An ecological risk assessment was conducted on the risk to fish of chemical contaminants detected in the habitat of Albula vulpes in South Florida, to evaluate whether contaminants may be a driver of declines in the recreational bonefish fishery. All available contaminant detection data from Biscayne Bay, Florida Bay, and the Florida Keys were compared to federal and state guidelines for aquatic health to identify Contaminants of Potential Ecological Concern (COPECS). For these COPECs, species sensitivity distributions were constructed and compared with recent detections at the 90^th centile of exposure. Copper in Biscayne Bay was identified as the highest …

The Impact Of Endocrine-Disrupting Chemicals On Wildlife Conservation, Eda Reed

Honors Theses

Endocrine-disrupting chemicals (EDCs), such as those from plastics and pesticides, have been hypothesized to affect wildlife populations. According to the U.S. National Institute of Environmental Health Sciences, EDCs ‘are chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife.’ A growing number of studies suggest wildlife are being exposed to EDCs, but how EDCs affect wildlife health and wildlife conservation is less well-understood. Through scientific literature analysis and a survey of wildlife conservationists and practitioners, this study aims to determine the current state of knowledge and data …

Extractability And Chemical Forms Of Radioactive Cesium In Designated Wastes Investigated In An On-Site Test, Yoko Fujikawa, Hiroaki Ozaki, Xiaming Chen, Shogo Taniguchi, Ryouhei Takanami, Aiichiro Fujinaga, Shinji Sakurai, Paul Lewtas

Research outputs 2014 to 2021

In the aftermath of the 2011 accident at Fukushima Daiichi Nuclear Power Plant (F1 hereafter), municipal solid waste (MSW) contaminated with radioactive cesium (rad-Cs hereafter) has been generated in 12 prefectures in Japan. The Japanese Minister of Environment classified MSW that contained rad-Cs in the concentration more than 8,000 Bq/kg as “designated (solid) waste (DSW hereafter), and prescribed the collection, storage and transportation procedures. When MSW containing rad-Cs was incinerated, rad-Cs was concentrated in fly ash, and the ash often fell into the category of DSW. We have investigated a technique that can reduce the volume of the rad-Cs-contaminated fly-ash …

Success Stories And Emerging Themes In Conservation Physiology, Christine L. Madliger, Steven J. Cooke, Erica J. Crespi, Jennifer L. Funk, Kevin R. Hultine, Kathleen E. Hunt, Jason R. Rohr, Brent J. Sinclair, Cory D. Suski, Craig K. R. Willis, Oliver P. Love

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The potential benefits of physiology for conservation are well established and include greater specificity of management techniques, determination of cause–effect relationships, increased sensitivity of health and disturbance monitoring and greater capacity for predicting future change. While descriptions of the specific avenues in which conservation and physiology can be integrated are readily available and important to the continuing expansion of the discipline of ‘conservation physiology’, to date there has been no assessment of how the field has specifically contributed to conservation success. However, the goal of conservation physiology is to foster conservation solutions and it is therefore important to assess whether …

Perceptions Of Emergency Preparedness Among Immigrant Hispanics Living In Oklahoma City, Oklahoma, Rebekah Doyle

Walden Dissertations and Doctoral Studies

Tornadoes are occurring with increased frequency in Oklahoma. Emergency preparedness planning is essential to decreasing individuals' risks of injury or death from a tornado. Research on immigrant Hispanics' knowledge and perceptions of emergency preparedness is limited. The purpose of this study was to explore the perceptions and lived experiences of immigrant Hispanics who had experienced a tornado or other crisis weather conditions in Oklahoma during spring of 2013. The research questions explored their perceived risk for injury and knowledge of tornado preparedness planning. The health belief model provided the theoretical underpinnings for this qualitative phenomenological study. Semi structured interviews were …

Methylmercury Exposure Via Canned Tuna Fish Consumption And Breast Cancer, Jennifer Bodenrader

Walden Dissertations and Doctoral Studies

Widespread consumption of canned tuna fish since the 1950s may explain some of the increase in breast cancer prevalence in the United States and Europe. Although canned tuna is the primary source of human exposure to methylmercury, its role as an estrogen activating metalloestrogen has been overlooked in the etiology and incidence of breast cancer. Carcinogenic theory asserts that increased exposure to estrogen elevates the risk of breast cancer. The purpose of this population-based, case control study was to examine the association between canned tuna consumption, total blood mercury, and breast cancer in the NHANES 2003-2006 surveys. A multivariable logistic …

Corporate Social Responsibility/Sustainability Reporting Among The Fortune Global 250: Greenwashing Or Green Supply Chain?, John K. Lewis

Faculty and Staff - Articles & Papers

The sustainability reporting efforts of MNCs who are members of the Fortune Global 250 (FG250) was investigated. The focus was on sustainability reporting by MNCs of supply chain impacts. The reporting of FG250 MNCs was examined to determine if greenwashing was occurring or whether MNCs had committed to operating a green supply chain. A mixed methodology was used consisting of quantitative analysis of twenty-five MNC CSR/sustainability reports which were randomly selected from the FG250 listing. Qualitative analysis using content analysis was also conducted on the reports. Both methodologies concentrated on the sustainability reporting of the selected MNCs in regard to …

2016 Greenhouse Gas Inventory Report: Virginia Institute Of Marine Science, Green Team, Virginia Institute Of Marine Science, Pamela Braff, Elisabeth Clyne, Andrew J. Johnson, Patricia S. Thibodeau, Kelley Uhlig

Reports

During summer 2016 the VIMS Green Team completed an inventory of greenhouse gas (GHG) emissions from the Virginia Institute of Marine Science (VIMS) Gloucester Point campus during FY2015. GHG emissions were estimated using the Campus Carbon Calculator maintained by the Sustainability Institute at the University of New Hampshire, and compared to a previous GHG audit from FY2010.

Why Law Now Needs To Control Rather Than Follow Neo-Classical Economics, John William Draper

Librarian Scholarship at Penn Carey Law

Selfish utilitarianism, neo-classical economics, the directive of short-term income maximization, and the decision tool of cost-benefit analysis fail to protect our species from the significant risks of too much consumption, pollution, or population. For a longer-term survival, humanity needs to employ more than cost-justified precaution.

This article argues that, at the global level, and by extension at all levels of government, we need to replace neo-classical economics with filters for safety and feasibility to regulate against significant risk. For significant risks, especially those that are irreversible, we need decision tools that will protect humanity at all scales. This article describes …

Drinking Water And Autism: Using Spatial Cluster Detection To Explore Patterns Of Autism Cases In Lane County, Oregon, Sherry Sandreth

Walden Dissertations and Doctoral Studies

Autism Spectrum Disorders (ASD) are a complex array of neurological disorders with a diverse presentation, multiple etiologies, and long-term ramifications. Prevalence of ASD in the United States is about 1 in 50 children as of 2013, making it a significant public health problem. The etiology is not understood, and it is widely accepted that it is multicausal, with genetic and environmental influences. Prior research suggests an association between water source and ASD. Contaminants such as lead, arsenic, mercury, pharmaceuticals and pesticides found in water are associated with developmental disorders suggesting that a systematic review focused on water source was warranted. …

Assessing The Impacts Of Climate Change On The Surface Temperature Of Inland Lakes In Michigan, Kaitlin Reinl

Dissertations, Master's Theses and Master's Reports

The aim of this study was to validate and apply a lake model for predicting the susceptibility of small inland lakes in Michigan to changes in thermal regime and increased cyanobacteria growth as a result of future climate conditions. The Freshwater Lake Model was selected, tested for sensitivity to various inputs, and validated through comparison to observed conditions. The sensitivity analysis showed that the lake model was most sensitive to solar radiation, air temperature, and air humidity. Comparison of predicted climate data with observed conditions revealed highly variable climate model error. The lake model validation was conducted using 10 lakes …

Williston, Vt: Evaluating Child Lead Screening Rates And A Potential Exposure, Ethan R. Harlow

Family Medicine Clerkship Student Projects

The CDC recommends that all 1-and 2-year-old children be screened for lead and that the most effective measure for mitigating lead poisoning in children is through primary prevention. This study evaluates lead screening rates at a Family Medicine Clinic in Williston, VT and seeks to gather community perspective on a potential failure of primary prevention in the town.

Human Shields And Redistribution Of Prey Species Complicate The Utility Of Protected Areas As Ecological Baselines, Wesley Sarmento

Graduate Student Theses, Dissertations, & Professional Papers

A key goal of protected areas is the conservation of biodiversity, an aim that garners increasing public support through positive experiences. Increasing visitation, however, can come at the cost of reduced ecological integrity. A fundamental conundrum is that if parks are to serve as our most pristine places, then we must understand how our presence alters species interactions. Species redistributing closer to people is of growing management concern both in and out of national parks because of 1) human safety, 2) animal health, and 3) ecological consequences. Across parks drivers of distributional change are often dissimilar, and include movement to …