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Full-Text Articles in Physical Sciences and Mathematics

Molecular Mechanisms Of Amyloid-Like Fibril Formation, Sharareh Jalali Aug 2023

Molecular Mechanisms Of Amyloid-Like Fibril Formation, Sharareh Jalali

Dissertations

Proteins play a critical role in living systems by performing most of the functions inside cells. The latter is determined by the protein's three-dimensional structure when it is folded in its native state. However, under pathological conditions, proteins can misfold and aggregate, accounting for the formation of highly ordered insoluble assemblies known as amyloid fibrils. These assemblies are associated with diseases like Parkinson's and Alzheimer's. Strong evidence suggests that three mechanisms are critical for forming amyloid fibrils. These mechanisms are the nucleation of amyloid fibrils in solution (primary nucleation) as well as on the surface of existing fibrils (secondary nucleation) …


Exploring Topological Phonons In Different Length Scales: Microtubules And Acoustic Metamaterials, Ssu-Ying Chen Aug 2023

Exploring Topological Phonons In Different Length Scales: Microtubules And Acoustic Metamaterials, Ssu-Ying Chen

Dissertations

The topological concepts of electronic states have been extended to phononic systems, leading to the prediction of topological phonons in a variety of materials. These phonons play a crucial role in determining material properties such as thermal conductivity, thermoelectricity, superconductivity, and specific heat. The objective of this dissertation is to investigate the role of topological phonons at different length scales.

Firstly, the acoustic resonator properties of tubulin proteins, which form microtubules, will be explored The microtubule has been proposed as an analog of a topological phononic insulator due to its unique properties. One key characteristic of topological materials is the …


Quantifying Balance: Computational And Learning Frameworks For The Characterization Of Balance In Bipedal Systems, Kubra Akbas Aug 2023

Quantifying Balance: Computational And Learning Frameworks For The Characterization Of Balance In Bipedal Systems, Kubra Akbas

Dissertations

In clinical practice and general healthcare settings, the lack of reliable and objective balance and stability assessment metrics hinders the tracking of patient performance progression during rehabilitation; the assessment of bipedal balance plays a crucial role in understanding stability and falls in humans and other bipeds, while providing clinicians important information regarding rehabilitation outcomes. Bipedal balance has often been examined through kinematic or kinetic quantities, such as the Zero Moment Point and Center of Pressure; however, analyzing balance specifically through the body's Center of Mass (COM) state offers a holistic and easily comprehensible view of balance and stability.

Building upon …


Utilizing Low-Cost Sensors To Monitor Indoor Air Quality In Mongolian Gers, Callum Flowerday, Jaron C. Hansen, Phil Lundrigan, Christopher Kitras Aug 2023

Utilizing Low-Cost Sensors To Monitor Indoor Air Quality In Mongolian Gers, Callum Flowerday, Jaron C. Hansen, Phil Lundrigan, Christopher Kitras

Faculty Publications

Air quality has important climate and health effects. There is a need, therefore, to monitor air quality both indoors and outdoors. Methods of measuring air quality should be cost-effective if they are to be used widely, and one such method is low-cost sensors (LCS). This study reports on the use of LCSs in Ulaanbataar, Mongolia to measure PM2.5 concentrations inside yurts or “gers”. Some of these gers were part of a non-government agency (NGO) initiative to improve insulating properties of these housing structures. The goal of the NGO was to decrease particulate emissions inside the gers; a secondary result …


Self-Reported Consumption Of Bottled Water V. Tap Water In Appalachian And Non-Appalachian Kentucky, Jason W. Marion Aug 2023

Self-Reported Consumption Of Bottled Water V. Tap Water In Appalachian And Non-Appalachian Kentucky, Jason W. Marion

Journal of Appalachian Health

Introduction: Quantitative studies on drinking water perceptions in Appalachia are limited. High-profile water infrastructure failures in the U.S. and Eastern Kentucky, coupled with human-made and natural disasters in the Appalachian Region, have likely impacted opinions regarding tap water.

Purpose: To use existing unexplored data to describe baseline tap water v. bottled water consumption in Kentucky.

Methods: Telephone-based cross-sectional data were obtained from the 2013 Kentucky Health Issues Poll (KHIP) directed by the Foundation for a Healthy Kentucky. Among many items in KHIP, self-reported consumption of bottled water over tap water, reasons for bottled water use, and demographic data were obtained. …


Reconstructing 42 Years (1979–2020) Of Great Lakes Surface Temperature Through A Deep Learning Approach, Miraj Kayastha, Tao Liu, Daniel Titze, Timothy C. Havens, Chenfu Huang, Pengfei Xue Aug 2023

Reconstructing 42 Years (1979–2020) Of Great Lakes Surface Temperature Through A Deep Learning Approach, Miraj Kayastha, Tao Liu, Daniel Titze, Timothy C. Havens, Chenfu Huang, Pengfei Xue

Michigan Tech Publications, Part 2

Accurate estimates for the lake surface temperature (LST) of the Great Lakes are critical to understanding the regional climate. Dedicated lake models of various complexity have been used to simulate LST but they suffer from noticeable biases and can be computationally expensive. Additionally, the available historical LST datasets are limited by either short temporal coverage (<30 >years) or lower spatial resolution (0.25° × 0.25°). Therefore, in this study, we employed a deep learning model based on Long Short-Term Memory (LSTM) neural networks to produce a daily LST dataset for the Great Lakes that spans an unparalleled 42 years (1979–2020) at …


Freshwater And Saline Flood Plain Wetlands Of The North Platte River - Sources And Seasonal Dynamics: Kiowa Wildlife Management Area, Morrill, Ne, Anne M. Matherne Aug 2023

Freshwater And Saline Flood Plain Wetlands Of The North Platte River - Sources And Seasonal Dynamics: Kiowa Wildlife Management Area, Morrill, Ne, Anne M. Matherne

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

The Kiowa Wildlife Management Area (WMA), a 1 mi² wetland and upland on the North Platte River, was acquired by the Nebraska Game and Parks Commission (NGPC) in 1993. The WMA comprises two distinct wetland types, alkaline and freshwater, both of which provide important wildlife habitat. It was the goal of this project to understand the hydrology controlling the development and maintenance of these wetlands in order to anticipate the affect of management strategies on the wetland complex. The study was designed to develop a comprehensive picture of the hydrogeology of both the fresh and alkaline portions of the WMA, …


Willa Cather Ecological Prairie: An Ecological Overview, Harold G. Nagel Aug 2023

Willa Cather Ecological Prairie: An Ecological Overview, Harold G. Nagel

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

This report includes data gathered on the ecology of a 610 acre mixed grass prairie in south-central Nebraska over a two year period.

An attempt was made to identify as many of the plant and animal species present and to determine density and standing crop biomass wherever possible, under the time and financial constraints present. Few attempts have been made to develop complete species checklists for both animals and plants in prairies. The data collected are considered baseline conditions against which comparisons can be made after a management plan is carried out.

This study of Cather Prairie had several objectives. …


The Flora Of The Oak-Wooded Drainages At The Timber Point Area, Southeastern Butler County, Nebraska, Steven B. Rolfsmeier Aug 2023

The Flora Of The Oak-Wooded Drainages At The Timber Point Area, Southeastern Butler County, Nebraska, Steven B. Rolfsmeier

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

The Timber Point Area is a 160-acre recreational/wildlife area occupying to S½ of the SW¼ sec. 22 and the adjacent N½ of the NW¼ sec. 27, T14N R4E. The area is located in the loess-mantled glacial-till hills of southeast Nebraska not far from the terminal moraine of the Pre-Illinoian glacial sheet, one mile south and two miles east of the present town of Brainard. The uplands at Timber Point were apparently in pasture prior to purchase by the NRD, with some cultivated fields occupying the lower ground along a stream valley which southwest to northeast through the property. This small …


The Flora Of Two Oak Drainages At The Red Cedar Area, Southwestern Saunders County, Nebraska, Steven B. Rolfsmeier Aug 2023

The Flora Of Two Oak Drainages At The Red Cedar Area, Southwestern Saunders County, Nebraska, Steven B. Rolfsmeier

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

The Red Cedar Area is a 175 acre recreational/wildlife area occupying the SE¼ sec. 20, T14N R5E and a small portion of sec. 29 directly to the south. The area is located in the glacial-till hills of southeast Nebraska ca 5 mi. north and 2 mi. west of Valpraiso. The bulk of the area was cultivated farmland prior to purchase by the NRD, and nearly all upland areas here were cultivated cropland, save for some steep oak-wooded drainages on the east side of Hunter’s Slough, which ran northwest to southeast through the property. The creek was dammed after NRD purchase …


The Vascular Plants Of The Woodlands Of South Table Creek In The Vicinity Of The National Arbor Day Center, Nebraska City, Nebraska, Steven B. Rolfsmeier Aug 2023

The Vascular Plants Of The Woodlands Of South Table Creek In The Vicinity Of The National Arbor Day Center, Nebraska City, Nebraska, Steven B. Rolfsmeier

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

The objective of this study is to describe the composition of the vascular plant flora of a three-quarter mile stretch of woodland along South Table Creek managed by the National Arbor Day Foundation in Nebraska City. This 50-60 acre woodland is representative of the many small tributaries of the Missouri River in southeastern Nebraska, and may represent the only natural “preserve” of native forest on the west side of the Missouri River between Fontenelle Forest and Indian Cave State Park. All naturally-occurring species encountered in this study are listed alphabetically by family at the end of this paper, and a …


The Flora Of Meadowlark Prairie, Northeastern Seward County, Nebraska, Steven B. Rolfsmeier Aug 2023

The Flora Of Meadowlark Prairie, Northeastern Seward County, Nebraska, Steven B. Rolfsmeier

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

This report is on the flora of the Meadowlark Prairie. The prairie is an approximately 7 acre remnant of virgin tall-grass prairie in extreme northeastern Seward County, Nebraska. The remnant is triangular in shape and lies on a gentle southeast-facing slope with a total relief of 50 ft., along the east boundary of the Meadowlark Recreation Area. The prairie is surrounded on the east side by a small brome-infested prairie remnant and cultivated field off the NRD property, and on the remaining sides by formerly cultivated fields now seeded to native warm-season grasses. Soils in the area are primarily derived …


The Flora And Plant Communities Of The Ceresco Saline Basins, Southern Saunders County, Nebraska, Steven B. Rolfsmeier Aug 2023

The Flora And Plant Communities Of The Ceresco Saline Basins, Southern Saunders County, Nebraska, Steven B. Rolfsmeier

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

This report is on the flora and plant communities of the Ceresco Saline Basins. The basins are along Rock Creek east of Ceresco and represent the northernmost representatives of the “eastern saline marsh” community in Nebraska. Eastern saline marshland is mostly restricted to the Salt Creek drainage in northern and central Lancaster County, though the Ceresco basins extend a mile or more north into Saunders County in the floodplain of Rock Creek. Some of the wetland in this area is currently under management of the Nebraska Game and Parks Commission, while some of the northernmost portions of the basins are …


Usa: Wolf Connection And Inclusive, Safe Spaces For All, Patrick Fuery, Kelli Fuery Aug 2023

Usa: Wolf Connection And Inclusive, Safe Spaces For All, Patrick Fuery, Kelli Fuery

CCI Books and Book Chapters

"Wolf Connection is a wolf sanctuary located on the outskirts of a rural town, Acton, California, nestled in the Angeles National Forest. The sanctuary consists of 165 acres of stunning woodland and high desert mountains, including a year-round stream. It is located within a one-hour drive from Los Angeles. Wolf Connection runs a series of programmes based around issues of mental health, addressing social and economic inequality, and providing strategies for resilience and well-being. Wolf Connection identifies the following as its core business activities: Providing Animal Rescue and Wildlife Preservation; At-Risk Youth Education and Empowerment; Community Empowerment; and Environmental Awareness …


Saturating Growth Rate Against Phosphorus Concentration Explained By Macromolecular Allocation, Gabrielle Armin, Jongsun Kim, Keisuke Inomura Aug 2023

Saturating Growth Rate Against Phosphorus Concentration Explained By Macromolecular Allocation, Gabrielle Armin, Jongsun Kim, Keisuke Inomura

School of Earth, Environmental, and Marine Sciences Faculty Publications and Presentations

The saturating relationship between phytoplankton growth rate and environmental nutrient concentration has been widely observed, yet the mechanisms behind the relationship remain elusive. Here, we use a mechanistic model of phytoplankton and show that the saturating relationship between growth rate and phosphorous concentration can be interpreted by intracellular macromolecular allocation. At low nutrient levels, the diffusive nutrient transport linearly increases with the phosphorous concentration, while the internal phosphorous requirement increases with the growth rate, leading to a non-linear increase in the growth rate with phosphorous. This increased phosphorous requirement is due to the increased allocation to biosynthetic and photosynthetic molecules. …


Sctiger: A Deep-Learning Method For Inferring Gene Regulatory Networks From Case Versus Control Scrna-Seq Datasets., Madison Dautle, Shaoqiang Zhang, Yong Chen Aug 2023

Sctiger: A Deep-Learning Method For Inferring Gene Regulatory Networks From Case Versus Control Scrna-Seq Datasets., Madison Dautle, Shaoqiang Zhang, Yong Chen

College of Science & Mathematics Departmental Research

Inferring gene regulatory networks (GRNs) from single-cell RNA-seq (scRNA-seq) data is an important computational question to find regulatory mechanisms involved in fundamental cellular processes. Although many computational methods have been designed to predict GRNs from scRNA-seq data, they usually have high false positive rates and none infer GRNs by directly using the paired datasets of case-versus-control experiments. Here we present a novel deep-learning-based method, named scTIGER, for GRN detection by using the co-differential relationships of gene expression profiles in paired scRNA-seq datasets. scTIGER employs cell-type-based pseudotiming, an attention-based convolutional neural network method and permutation-based significance testing for inferring GRNs among …


Broadband Cavity-Enhanced Absorption Spectroscopy (Bbceas) Coupled With An Interferometer For On-Band And Off-Band Detection Of Glyoxal, Callum Flowerday, Jaron Hansen, Ryan Thalman Aug 2023

Broadband Cavity-Enhanced Absorption Spectroscopy (Bbceas) Coupled With An Interferometer For On-Band And Off-Band Detection Of Glyoxal, Callum Flowerday, Jaron Hansen, Ryan Thalman

ScholarsArchive Data

These data are the raw data from the BBCEAS. The "data_" files are the PMT data and the "DualDetection_08_02_2023" files are the spectrograph data. The PMT data are found in column 7 of the sheet. Column 1 is the time stamp.


Table Of Contents Aug 2023

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.


Cytokine Data For Cytokine Profile Assessment From Peruvian Pinniped (Arctocephalus Australis And Otaria Byronia) Plasma, Mykenzee Munaco, Milton Levin, Michael Adkesson, Susana Cárdenas-Alayzad, Dimitrios G. Giarikos, Amy C. Hirons Aug 2023

Cytokine Data For Cytokine Profile Assessment From Peruvian Pinniped (Arctocephalus Australis And Otaria Byronia) Plasma, Mykenzee Munaco, Milton Levin, Michael Adkesson, Susana Cárdenas-Alayzad, Dimitrios G. Giarikos, Amy C. Hirons

SECLER Data

Large colonies of two vulnerable, sympatric pinniped species, Peruvian fur seals (Arctocephalus australis Peruvian subpopulation; PFS) and South American sea lions (Otaria byronia; SASL), reside and reproduce in Punta San Juan, Peru (PSJ) where they are exposed to stressors such as contaminants and El Niño Southern Oscillation (ENSO) events. The use of cytokines as immune biomarkers can be indicative of an animal’s health and function by allowing for the assessment of an individual's cytokine balance as type I helper T cells (Th1) or type II helper T cells (Th2) dominant. Utilizing archived pinniped plasma samples from 2009-2019 …


Online Data Transmission Reduction Scheme For Energy Conservation In Wireless Video Sensor Networks, Iman Kadhum Abbood, Ali Kadhum Idrees Aug 2023

Online Data Transmission Reduction Scheme For Energy Conservation In Wireless Video Sensor Networks, Iman Kadhum Abbood, Ali Kadhum Idrees

Karbala International Journal of Modern Science

Wireless Video Sensor Networks (WVSNs) are networks of low-cost, low-power camera sensor nodes. These nodes communicate locally and process information to meet an application's goal. WVSNs are extensively used in diverse monitoring applications, such as security, military, industrial, medical, and environmental monitoring. However, the transmission of large amounts of data collected by video sensor nodes in WVSNs poses challenges in terms of energy consumption, bandwidth usage, and network congestion. Reducing energy for processing and transmitting data in WVSNs is difficult due to the huge amount of sensed data in real-time. To address this issue, this paper proposes an Online Data …


Biogenesis Synthesis Of Zno Nps: Its Adsorption And Photocatalytic Activity For Removal Of Acid Black 210 Dye, Zahraa A. Najm, Mohammed A. Atiya, Ahmed K. Hassan Aug 2023

Biogenesis Synthesis Of Zno Nps: Its Adsorption And Photocatalytic Activity For Removal Of Acid Black 210 Dye, Zahraa A. Najm, Mohammed A. Atiya, Ahmed K. Hassan

Karbala International Journal of Modern Science

This study investigated the treatment of textile wastewater contaminated with Acid Black 210 dye (AB210) using zinc oxide nanoparticles (ZnO NPs) through adsorption and photocatalytic techniques. ZnO NPs were synthesized using a green synthesis process involving eucalyptus leaves as reducing and capping agents. The synthesized ZnO NPs were characterized using UV-Vis spectroscopy, SEM, EDAX, XRD, BET, Zeta potential, and FTIR techniques. The BET analysis revealed a specific surface area and total pore volume of 26.318 m2/g. SEM images confirmed the crystalline and spherical nature of the particles, with a particle size of 73.4 nm. A photoreactor was designed …


Scale Model Experiments Of Toxic Gas Production From The Combustion Of Polymers When Applied With Different Droplet Sizes Of Water Mist, Nicharee Thinnakornsutubutr, Masayuki Mizuno, Kazunori Kuwana Aug 2023

Scale Model Experiments Of Toxic Gas Production From The Combustion Of Polymers When Applied With Different Droplet Sizes Of Water Mist, Nicharee Thinnakornsutubutr, Masayuki Mizuno, Kazunori Kuwana

Progress in Scale Modeling, an International Journal

This research experimentally investigated the combustion of polymeric materials with water mist application in an enclosure, with an emphasis on the production of toxic gases. Two different diameters, ~100 and ~260 μm, were tested. The experimental conditions were determined based on Froude similarity laws for low drop Reynolds number conditions. Droplets and polymers’ physical and chemical properties influence the burning/extinguishing behavior and toxic-gas evolution. In general, larger droplets can extinguish a fire in a shorter time, and toxic gas concentrations in a test chamber decreased more rapidly. However, the large droplets tended to cause the flame expansion phenomenon for thermoplastics …


Making The Error Bar Overlap Myth A Reality: Comparative Confidence Intervals, Frank S. Corotto Aug 2023

Making The Error Bar Overlap Myth A Reality: Comparative Confidence Intervals, Frank S. Corotto

Georgia Journal of Science

Many interpret error bars to mean that if they do not overlap the difference is statistically “significant”. This overlap rule is really an overlap myth; the rule does not hold true for any conventional type of error bar. There are rules of thumb for estimating P values, but it would be better to show error bars for which the overlap rule holds true. Here I explain how to calculate comparative confidence intervals which, when plotted as error bars, let us judge significance based on overlap or separation. Others have published on these intervals (the mathematical basis goes back to John …


Research On China’S Marine Protected Areas Policy Based On Kunming-Montreal Global Biodiversity Framework 2030 Targets, Ke Duan, Xiulin Wang Aug 2023

Research On China’S Marine Protected Areas Policy Based On Kunming-Montreal Global Biodiversity Framework 2030 Targets, Ke Duan, Xiulin Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The Kunming-Montreal Global Biodiversity Framework adopted by the United Nations Convention on Biological Diversity (CBD) at the Conference of Parties (COP15) has set a series of targets, including protecting at least 30% of the oceans by 2030 worldwide. In China, how to build a marine ecological civilization in synergy with the targets has become an important issue. This study analyzes the necessity of accelerating the construction of marine protected areas in China from the perspectives of adapting to international trends, fulfilling the responsibilities of international conventions, safeguarding maritime rights and interests, and implementing the maritime power and strategy. The feasibility …


Ultrasound Assisted Comparative Study Of Fucolam And So-Dium Alginate And Impact On Their Physiochemical Proper-Ties Using Box-Behnken Design, Uday Bagale, Ammar Kadi, Artem Malinin, Varisha Anjum, Irina Potoroko Aug 2023

Ultrasound Assisted Comparative Study Of Fucolam And So-Dium Alginate And Impact On Their Physiochemical Proper-Ties Using Box-Behnken Design, Uday Bagale, Ammar Kadi, Artem Malinin, Varisha Anjum, Irina Potoroko

Karbala International Journal of Modern Science

The article discusses about the possibility of comparing the impact of ultrasonic treatment on fucolam and sodium algi-nate. The purpose was to study the effect of micronization on the sulfated heteropolysaccharide fucolam, analyzing its dispersed state and accessibility by reducing its molecular weight and increasing antioxidant activity. The optimization of the micronization process was carried out using the Box-Behnken Design (BBD) method, with a sonication time ranging from 15 to 45 min, power ranging from 50 to 100 W/cm2, and temperature between 30 °C and 40 °C. The fixed lower fucolam concentration was 0.1%. The results illustrated that sonochemical treatment …


Deep Learning-Based Cad System For Predicting The Covid-19 X-Ray Images, Aqeel R. Talib, Hana’ M. Ali Aug 2023

Deep Learning-Based Cad System For Predicting The Covid-19 X-Ray Images, Aqeel R. Talib, Hana’ M. Ali

Karbala International Journal of Modern Science

According to World Health Organization data, Coronavirus (COVID-19) has infected about 660, 378, 145 patients around the world. It is nonetheless difficult for physicians to detect COVID-19 infections out of CT or X-ray radiographs. Thus, several computer-aided diagnosis (CAD) systems based on deep learning and radiographs were developed to detect COVID-19 infections. However, the majority of approaches considered small datasets, which is ineligible to provide diverse COVID-19 radiographs. This work utilizes a massive number of X-ray radiographs, and compared standard CNN, DenseNet-121, and GoogLeNet for isolating COVID-19 infections out from normal and other pneumonia radiographs. The dataset in this work …


The Influence Of Framing And Recent Experience On Farmer Choices In Experimental Games Depicting Risk-Reducing Agricultural Technologies, Ana Maria Ospina Tobar Aug 2023

The Influence Of Framing And Recent Experience On Farmer Choices In Experimental Games Depicting Risk-Reducing Agricultural Technologies, Ana Maria Ospina Tobar

Electronic Theses and Dissertations

Climate change is a major threat to food security, particularly in low and middle-income countries that are highly dependent on staple crops for subsistence. The vulnerability of staple crops, like maize, in the face of climate change, is increasing due to the increasing frequency of droughts. This thesis aims to evaluate two mechanisms through which farmers may be more willing to adopt new technologies that increase their resilience to climate change: First, I evaluate the effectiveness of a new virtual maize farming game as a learning tool to teach farmers about the outcomes they could obtain under different weather events …


Integrating Environmental Dna, Traditional Fisheries Techniques, And Species Distribution Modeling To Assess Bridle Shiner Status In Maine, Lara S. Katz Aug 2023

Integrating Environmental Dna, Traditional Fisheries Techniques, And Species Distribution Modeling To Assess Bridle Shiner Status In Maine, Lara S. Katz

Electronic Theses and Dissertations

The bridle shiner (Notropis bifrenatus) is a small minnow species native to the eastern United States and southeastern Canada. The species is declining dramatically throughout most of its native range and has legal protection or concern status in thirteen states and two Canadian provinces. In Maine, the bridle shiner is listed as a Species of Special Concern and considered a Species of Greatest Conservation Need, partially because we lack a basic understanding of their status and distribution within the state. Bridle shiners have historically been found in southern and western Maine in densely vegetated, shallow habitats along the …


Untangling Influences Of Community Dynamics At The Coastal Interface, Hannah N. Mittelstaedt Aug 2023

Untangling Influences Of Community Dynamics At The Coastal Interface, Hannah N. Mittelstaedt

Electronic Theses and Dissertations

Ecosystems at the land-sea interface are subject to a multitude of abiotic and biotic factors that shape which species occupy this habitat. Through my dissertation, I explore how such factors influence coastal communities in the Gulf of Maine. In Chapter 1 I investigate the ability of an intertidal foundation species (rockweed) to dampen local abiotic drivers of community assembly. I found that the influence of site characteristics on meiofaunal community structure was not completely denuded by foundation species presence. Additionally, large scale regional drivers had a strong influence on communities but interact with local abiotic characteristics and foundation species. Chapter …


Additive Effects Of Cyclic Peptide [R4w4] When Added Alongside Azithromycin And Rifampicin Against Mycobacterium Avium Infection, Melissa Kelley, Kayvan Sasaninia, Arbi Abnousian, Ali Badaoui, James Owens, Abrianna Beever, Nala Kachour, Rakesh Kumar Tiwari, Vishwanath Venketaraman Aug 2023

Additive Effects Of Cyclic Peptide [R4w4] When Added Alongside Azithromycin And Rifampicin Against Mycobacterium Avium Infection, Melissa Kelley, Kayvan Sasaninia, Arbi Abnousian, Ali Badaoui, James Owens, Abrianna Beever, Nala Kachour, Rakesh Kumar Tiwari, Vishwanath Venketaraman

Pharmacy Faculty Articles and Research

Mycobacterium avium (M. avium), a type of nontuberculous mycobacteria (NTM), poses a risk for pulmonary infections and disseminated infections in immunocompromised individuals. Conventional treatment consists of a 12-month regimen of the first-line antibiotics rifampicin and azithromycin. However, the treatment duration and low antibiotic tolerability present challenges in the treatment of M. avium infection. Furthermore, the emergence of multidrug-resistant mycobacterium strains prompts a need for novel treatments against M. avium infection. This study aims to test the efficacy of a novel antimicrobial peptide, cyclic [R4W4], alongside the first-line antibiotics azithromycin and rifampicin in reducing M. avium survival. Colony-forming unit (CFU) …