Physical Sciences and Mathematics Commons^™

Semi-Parametric Regression For The Area Under The Receiver Operating Characteristic Curve, Lori E. Dodd, Margaret S. Pepe

UW Biostatistics Working Paper Series

Medical advances continue to provide new and potentially better means for detecting disease. Such is true in cancer, for example, where biomarkers are sought for early detection and where improvements in imaging methods may pick up the initial functional and molecular changes associated with cancer development. In other binary classification tasks, computational algorithms such as Neural Networks, Support Vector Machines and Evolutionary Algorithms have been applied to areas as diverse as credit scoring, object recognition, and peptide-binding prediction. Before a classifier becomes an accepted technology, it must undergo rigorous evaluation to determine its ability to discriminate between states. Characterization of …

Partial Auc Estimation And Regression, Lori E. Dodd, Margaret S. Pepe

UW Biostatistics Working Paper Series

Accurate disease diagnosis is critical for health care. New diagnostic and screening tests must be evaluated for their abilities to discriminate disease from non-diseased states. The partial area under the ROC curve (partial AUC) is a measure of diagnostic test accuracy. We present an interpretation of the partial AUC that gives rise to a new non-parametric estimator. This estimator is more robust than existing estimators, which make parametric assumptions. We show that the robustness is gained with only a moderate loss in efficiency. We describe a regression modelling framework for making inference about covariate effects on the partial AUC. Such …

Cross-Modal Enhancement Of Perceived Brightness: Sensory Interaction Versus Response Bias, Yoav Arieh, Lawrence E. Marks, Eric C. Odgaard

Department of Psychology Faculty Scholarship and Creative Works

Stein, London, Wilkinson, and Price (1996) reported the presence of cross-modal enhancement of perceived visual intensity: Participants tended to rate weak lights as brighter when accompanied by a concurrent pulse of white noise than when presented alone. In the present study, two methods were used to determine whether the enhancement reflects an early-stage sensory process or a later-stage decisional process, such as a response bias. First, the enhancement was eliminated when the noise accompanied the light on only 25% versus 50% of the trials. Second, the enhancement was absent when tested with a paired-comparison method. These findings are consistent with …

The Press For Help Project Concept, Program And Working Paper Of Emmanuel Mario B Santos And His Marc Guerrero Communications Inc., Emmanuel Mario B. Santos Aka Marc Guerrero

Emmanuel Mario B Santos aka Marc Guerrero

FORETHOUGHT. DECLARATION OF IDEAOLOGY AND PRINCIPLES. VISION. MISSION. VALUES. GOALS. BASIC HELP project. EDUCATIONAL HELP project. MEDICAL HELP project. LEGAL HELP project. EMERGENCY HELP project. LIVELIHOOD HELP project. SPIRITUAL and CULTURAL HELP project. ENVIRONMENTAL HELP project. REENGINEERING HELP project. INTERNATIONAL HELP project. QUADRO CREDO Matthew 5.1-12, the Jerusalem Bible. The Universal Filipino Beatitudes. SALIN SA FILIPINO. DESIDERATA. AFTERTHOUGHT.

Development Of Dose Coefficients For Radionulides Produced In Spallation Neutron Sources: Annual Report, Phillip W. Patton, Mark Rudin

Transmutation Sciences Physics (TRP)

The University of Nevada, Las Vegas (UNLV) Transmutation Research Program has been tasked to support U.S. Department of Energy (DOE) efforts to assess the health risks associated with the operation of each of their accelerator-driven nuclear facilities for both NEPA and PSAR development. Quantifying the radiological risks to workers will have to be addressed during the design and siting of each of these facilities. U.S. Environmental Protection Agency (EPA) Federal Guidance Report No. 11 “Limiting Values of Intake and Air Concentration and Dose Conversion Factors for Inhalation, Submersion, and Ingestion”, developed two derived guides, Annual Limit on Intake (ALI) and …

Phosphoproteomic Studies Of Smooth Muscle Contraction: Investigation Of Differential Phosphorylation In Relaxed/Contracted Rat Aortic Smooth Muscle Tissue Using Maldi-Tof Ms, Tonya M. Pekar

Theses, Dissertations and Capstones

Many human disorders are associated with the malfunction of smooth muscle tissue, or are related to the capabilities of its proper function—asthma, glaucoma, renal inefficiency, hypertension, and cardiovascular disease. Dysfunctional proteins are frequently implicated as the source of such disorders. As the second highest cause of death in the United States, the epidemic of cardiovascular disease makes the study of smooth muscle of utmost concern.

The capabilities of proteomics and mass spectrometry allow the entire proteome complement of a cell or tissue type to be analyzed at once. This investigation employs such techniques in an effort to better understand the …

Prevention Of Poxvirus Infection By Tetrapyrroles, Avril Rm Chen-Collins, Dabney W. Dixon, Andrei N. Vzorov, Luigi G. Marzilli, Richard W. Compans

Chemistry Faculty Publications

Background: Prevention of poxvirus infection is a topic of great current interest. We report inhibition of vaccinia virus in cell culture by porphyrins and phthalocyanines. Most previous work on the inhibition of viruses with tetrapyrroles has involved photodynamic mechanisms. The current study, however, investigates light-independent inhibition activity.

Methods: The Western Reserve (WR) and International Health Department-J (IHD-J) strains of vaccinia virus were used. Virucidal and antiviral activities as well as the cytotoxicity of test compounds were determined.

Results: Examples of active compounds include zinc protoporphyrin, copper hematoporphyrin, meso(2,6-dihydroxyphenyl)porphyrin, the sulfonated tetra-1-naphthyl and tetra-1- anthracenylporphyrins, selected sulfonated derivatives of halogenated tetraphenyl …

A Mathematical Model Of Immune Response To Tumor Invasion, Lisette De Pillis, Ami Radunskaya

All HMC Faculty Publications and Research

Recent experimental studies by Diefenbach et al. [1] have brought to light new information about how the immune system of the mouse responds to the presence of a tumor. In the Diefenbach studies, tumor cells are modified to express higher levels of immune stimulating NKG2D ligands. Experimental results show that sufficiently high levels of ligand expression create a significant barrier to tumor establishment in the mouse. Additionally, ligand transduced tumor cells stimulate protective immunity to tumor rechallenge. Based on the results of the Diefenbach experiments, we have developed a mathematical model of tumor growth to address some of the questions …

Short-Term Effects Of Ambient Particles On Mortality In The Elderly: Results From 28 Cities In The Aphea2 Project, E. Aga, E. Samoli, G. Touloumi, K. Katsouyanni, H.R. Anderson, E. Cadum, B. Forsberg, Patrick J. Goodman, A. Goren, F. Kotesovec, B. Kriz, M. Macarol-Hiti, S. Medina, A. Paldy, C. Schindler, J. Sunyer, P. Tittanen, B. Wojtyniak, D. Zmirou, J. Schwartz

Articles

ABSTRACT: Within the framework of the APHEA2 (Air Pollution on Health: a European Approach) project, the effects of ambient particles on mortality among persons o65 yrs were investigated. Daily measurements for particles with a 50% cut-off aerodynamic diameter of 10 mm (PM10) and black smoke (BS), as well as the daily number of deaths among persons o65 yrs of age, from 29 European cities, have been collected. Data on other pollutants and meteorological variables, to adjust for confounding effects and data on city characteristics, to investigate potential effect modification, were also recorded. For individual city analysis, generalised additive models extending …

Trace Analysis Of Organic Substances, Alan Giltinan

Theses

One of the major challenges facing the pharmaceutical industry is the control of the amount of trace contaminants during the manufacture of organic substances. Lowering the level of contamination improves the quality of the product and reduces possible side effects.

One of the main techniques used to detect trace contaminants is UV-VIS spectroscopy, where the unique absorption fingerprint of a chemical reveals its presence. UV-VIS absorption is based upon the Beer-Lambert Law. The critical point to note about this law is that the absorption is exponentially dependent on both the concentration of the absorber and the pathlength traversed by the …

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

President's Message

Journal of the South Carolina Academy of Science

No abstract provided.

Par Mediation Of Thrombin-Induced Effects On Motoneurons, Nadim Salman, Drew Watkins, Kate Hamel, Lakisha Gadsden, Sarah Funderburk, Victoria Turgeon

Journal of the South Carolina Academy of Science

No abstract provided.

Some Notes On Multiplicative Congruential Random Number Generators With Mersenne Prime Modulus 261-1., James Harris

Journal of the South Carolina Academy of Science

No abstract provided.

Embryogenesis In The Japanese Medaka, Oryzias Latipes, Laura Harris Harris, Lisa Sims, Roxann Stachiw

Journal of the South Carolina Academy of Science

No abstract provided.

Critical Thinking And Biology Instruction., David J. Stroup, John L. Frola

Journal of the South Carolina Academy of Science

No abstract provided.

The Journal Of Undergraduate Research: Volume 01

The Journal of Undergraduate Research

This is the complete issue of the South Dakota State University Journal of Undergraduate Research, Volume 1.

Development Of Dose Coefficients For Radionuclides Produced In Spallation Targets, Phillip W. Patton, Mark Rudin

Transmutation Sciences Physics (TRP)

Dose coefficients permit simple determination of radiation dose associated with various exposure scenarios, and ultimately permit radiation safety personnel to assess the health risks to workers in a nuclear facility. Specifically, radiation safety personnel use dose coefficients to determine the radiation dose incurred to a tissue or organ system from a given exposure. These parameters are often expressed in terms of Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs).

Results from this study will be used to produce ALIs and DACs for these rare radionuclides created by spallation target systems that are not included in Federal Guidance Report …

A Contrast-Based Neural Control System For Ant Navigation, Joanna R. Wares, Predrag-Peter Ilich, Daniel P. Dougherty

Department of Math & Statistics Faculty Publications

A mathematical model for a neural control system of ant locomotion was developed. Contrast-based detectors using excitation and inhibition were tuned to specific contrast orientations. A control system using multiple orientation contrast detectors was then developed and optimized for a model ant, which could move via a biased random walk. The system allowed sufficient control to guide the ant through various mazes.

Santa Clara Magazine, Volume 45 Number 3, Winter 2003, Santa Clara University

Santa Clara Magazine

10 - ACADEMIC EXCELLENCE AT SCU By Paul Locatelli, S.J. ln an adaptation of his convocation address, SCU 's president describes the University's goal to educate "the whole person."

12 - 'BECKHAM' BOOSTS SCU SOCCER By Victoria Hendel De La O. References to SCU in the hit movie have brought international attention to the women's soccer program.

14 - SEEKING SOLUTIONS Experts vi sit campus to discuss the issue of clergy abuse and work on a book about the topic.

18 - UNEARTHING THE PAST By Connie Skipitares. SCU archaeologists, anthropologists, and students probe a site near campus to learn …

Histological Effect Of Ascocotyle Tenuicollis (Digenea: Heterophyidae) Metacercarial Infection On The Heart Of Fundulus Heteroclitus (Teleostei: Cyprinodontidae), Toni Hicks, Edna Steele

Journal of the South Carolina Academy of Science

No abstract provided.

South Carolina Statewide Science Safety Project., Linda Sinclair, Jack Gerlovich, Rahul A. Parsa

Journal of the South Carolina Academy of Science

No abstract provided.

2002 & 2003 Annual Meeting Extended Abstracts

Journal of the South Carolina Academy of Science

No abstract provided.

Maternal And Sibling Influences On Seed Germination Of Aegilops Triuncialis Erin, Erin Scott, Andrew R. Dyer

Journal of the South Carolina Academy of Science

No abstract provided.

Scas Officers And Council Members 2003 - 2004

Journal of the South Carolina Academy of Science

No abstract provided.

Investigations Into The Etiology Of Ulcerative Lesions In Atlantic Menhaden, Brevoortia Tyrannus, Raemarie Ann Johnson

Dissertations, Theses, and Masters Projects

No abstract provided.

Space Ship Earth – Clinic In Forest, Nat Quansah

Nat Quansah

No abstract provided.

Historical Development Of The Linear Nonthreshold Dose-Response Model As Applied To Radiation, Ronald L. Kathren

The University of New Hampshire Law Review

[Excerpt] "Despite the nearly universal adoption of the linear nonthreshold dose response model (LNT) as the primary basis for radiation protection standards for the past half century, the LNT remains highly controversial and a contentious topic of discussion among health physicists, radiation biologists, and other radiological scientists. Indeed, it has been pointed out that the LNT has assumed the status of a paradigm, synonymous with an ideal, standard, or paragon or perhaps to some, a sacred cow. Reduced to its very basics, the LNT postulates that every increment of ionizing radiation dose, however small, carries with it a commensurate increase …

Detectability Of Excitatory Versus Inhibitory Drive In An Integrate-And-Fire-Or-Burst Thalamocortical Relay Neuron Model, Gregory D. Smith, S. M. Sherman

Arts & Sciences Articles

Although inhibitory inputs are often viewed as equal but opposite to excitatory inputs, excitatory inputs may alter the firing of postsynaptic cells more effectively than inhibitory inputs. This is because spike cancellation produced by an inhibitory input requires coincidence in time, whereas an excitatory input can add spikes with less temporal constraint. To test for such potential differences, especially in the context of the function of thalamocortical (TC) relay nuclei, we used a stochastic “integrate-and-fire-or-burst” TC neuron model to quantify the detectability of excitatory and inhibitory drive in the presence and absence of the low-threshold Ca 2+ current, IT, and …

Quantitative Evaluation Of Hiv Preventon Programs, Edward Kaplan, Ron Brookmeyer

Ron Brookmeyer

How successful are HIV prevention programs? Which HIV prevention programs are most cost effective? Which programs are worth expanding and which should be abandoned altogether? This book addresses the quantitative evaluation of HIV prevention programs, assessing for the first time several different quantitative methods of evaluation