Physical Sciences and Mathematics Commons^™

Impact Of Information Breaches On Health Care Records, Anton Antony Arockiasamy

Walden Dissertations and Doctoral Studies

Although there were almost 3.5 million reported information breaches of health care data in the first quarter of 2019, health care providers do not know the extent of digital and nondigital breaches of patient medical records. The purpose of this quantitative, comparative study was to identify the difference between the individual patient records affected by digital versus nondigital breaches for three types of health care entities in the United States, health care providers, health care plans, and health care clearinghouses. Allman’s privacy regulation theory, the National Institute of Standards and Technology Privacy Framework, and ecological systems theory comprised the theoretical …

The Causes And Control Measures Of Extended Spectrum Beta-Lactamase Producing Enterobacteriaceae In Long-Term Care Facilities, Ismaila Olatunji Sule

Walden Dissertations and Doctoral Studies

Due to extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE), infections among residents are increasing in long-term care facilities (LTCFs), resulting in high rate of morbidity and healthcare costs. ESBL-PE resists empirical antibiotics and reduces treatment options, and a designated infection control team is unavailable to prevent the prevalence of the disease. Ecological theory guided this study. A systematic review and meta-analysis were conducted to characterize the causes of ESBL-PE and evaluate the infection control strategies within LTCFs. Multiple regression analysis (MRA) was included as supplementary statistical analysis to identify relationships between LTCFs, geographical locations, infection control measures (ICMs), and ESBL-PE. A systematic search …

Grappling With Covid-19 By Imposing And Lifting Nonpharmaceutical Interventions In Sri Lanka: A Modeling Perspective, Mahesh Jayaweera, Chamath Dannongoda, Dilum Dilshan, Janith Dissanayake, Hasini Perera, Jagath Manatunge, Buddhika Gunawardana

Physics and Astronomy Faculty Publications and Presentations

The imposition and lifting of non-pharmaceutical interventions (NPIs) to avert the COVID19 pandemic have gained popularity worldwide and will continue to be enforced until herd immunity is achieved. We developed a linear regression model to ascertain the nexus between the time-varying reproduction number averaged over a time window of six days (Rts) and seven NPIs: contact tracing, quarantine efforts, social distancing and health checks, hand hygiene, wearing of facemasks, lockdown and isolation, and health-related supports. Our analysis suggests that the second wave that emerged in Sri Lanka in early October 2020 continued despite numerous NPIs. The model indicates that the …

Philippine Medicinal Plants With Potential Immunomodulatory And Anti-Sars-Cov-2 Activities, Fabian M. Dayrit, Armando M. Guidote Jr, Nina Gloriani, Sheriah Laine M. De Paz-Silava, Irene M. Villaseñor, Rene Angelo S. Macahig, Mario A. Tan, John Ross N. Chua, Isidro C. Sia

Chemistry Faculty Publications

Coronavirus disease 2019 (COVID-19) continues to devastate the world’s health and economy, affecting all aspects of life leading to widespread social disruption. Even as several vaccines have been developed, their availability in developing countries is limited and their efficacy against the variants of SARS-CoV-2 (severe acute respiratory syndrome–coronavirus 2) needs to be continuously assessed. The World Health Organization (WHO) has acknowledged that vaccines alone will not overcome the global challenges of COVID-19. Medicinal plants may provide the needed support. Herein, we identify Philippine medicinal plants that possess phytochemicals with potential anti-SARS-CoV-2 activity and/or immunomodulatory properties that may strengthen one’s immune …

Water Pollution And Environmental Concerns In Anesthesiology, Marc Kostrubiak, Christine Vatovec, Lesley-Ann Dupigny-Giroux, Donna Rizzo, William Paganelli, Mitchell Tsai

Larner College of Medicine Fourth Year Advanced Integration Teaching/Scholarly Projects

Medications administered by anesthesia health care providers and subsequently excreted into the water supply system have the potential to affect ecological systems. Presently, there is a lack of literature examining which medications or metabolites enter the waste stream. Further, assessments of their potential environmental impact are often unknown or simply not considered as an externality of medical practice. Recent work examining the practice of anesthesiology has explored the solid waste stream, and the global warming potential of anesthetic gases, however the potential aquatic impacts remain unexplored. To address the potential for waterborne pollution and environmental toxicity, we extracted the total …

Welfare Performance Of Three Foothold Traps For Capturing North American River Otters Lontra Canadensis, Matthew J. Lovallo, H. B. White, J. D. Erb, M. S. Peek, Thomas J. Deliberto

United States Department of Agriculture Wildlife Services: Staff Publications

Foothold traps are effective tools for the live capture and restraint of wildlife for management and research. Successful river otter Lontra canadensis restoration programs throughout North America used them extensively. Restoration programs used a variety of methods and models of foothold traps, but comprehensive efforts to describe and quantify injuries associated with river otter captures have been limited. We evaluated injuries of river otters caught in three commercially available models of foothold traps including the number 11 double long-spring with standard jaws, the number 11 double long-spring with double jaws, and the number 2 coil-spring trap. Based on examinations of …

Evaluating The Incidence Of Melanoma And Lung Cancer Of Current And Former Active-Duty U.S. Military Who Were Deployed In Support Of Operation Enduring Freedom And Operation Iraqi Freedom, Brian Kovacic

Theses and Dissertations--Epidemiology and Biostatistics

The incidence of melanoma and lung cancer has been gradually increasing in the United States over the past three decades with the reputed causes due to etiological and environmental exposures, and tobacco usage. There has been concern that melanoma and lung cancer incidence among military personnel may be associated with deployment to environments with intense sun exposure and increased smoking rates due to post-traumatic stress disorder. The aim of this study was to examine associations between deployment in support of Operation Enduring Freedom (OEF) or Operation Iraqi Freedom (OIF), from 2001 through 2015, with subsequent melanoma and lung cancer incidence. …

Climate Impacts Associated With Reduced Diet Diversity In Children Across Nineteen Countries, Meredith T. Niles, Benjamin F. Emery, Serge Wiltshire, Molly E. Brown, Brendan Fisher, Taylor H. Ricketts

College of Agriculture and Life Sciences Faculty Publications

It is widely anticipated that climate change will negatively affect both food security and diet diversity. Diet diversity is especially critical for children as it correlates with macro and micronutrient intake important for child development. Despite these anticipated links, little empirical evidence has demonstrated a relationship between diet diversity and climate change, especially across large datasets spanning multiple global regions and with more recent climate data. Here we use survey data from 19 countries and more than 107 000 children, coupled with 30 years of precipitation and temperature data, to explore the relationship of climate to child diet diversity while …

Direct Multiplexing Of Low Order Aberration Modes In A Photopolymerbased Holographic Element For Analog Holographic Wavefront Sensing, Emma Branigan, Suzanne Martin, Matthew Sheehan, Kevin Murphy

Conference Papers

The fabrication of an analog holographic wavefront sensor, capable of detecting the low order defocus aberration, was achieved in an acrylamide-based photopolymer. While other implementations of holographic wavefront sensors have been carried out digitally, this process utilises a recording setup consisting only of conventional refractive elements so the cost and complexity of holographic optical element (HOE) production could be much reduced. A pair of diffraction spots, corresponding to a maximum and minimum amount of defocus, were spatially separated in the detector plane by multiplexing two HOEs with different carrier spatial frequencies. For each wavefront with a known aberration that was …

Use Of Lymesim 2.0 To Assess The Potential For Single And Integrated Management Methods To Control Blacklegged Ticks (Ixodes Scapularis; Acari: Ixodidae) And Transmission Of Lyme Disease Spirochetes, Shravani Chitineni, Elizabeth R. Gleim, Holly D. Gaff

Undergraduate Honors Theses

Annual Lyme disease cases continue to rise in the U.S. making it the most reported vector-borne illness in the country. The pathogen (Borrelia burgdorferi) and primary vector (Ixodes scapularis; blacklegged tick) dynamics of Lyme disease are complicated by the multitude of vertebrate hosts and varying environmental factors, making models an ideal tool for exploring disease dynamics in a time- and cost-effective way. In the current study, LYMESIM 2.0, a mechanistic model, was used to explore the effectiveness of three commonly used tick control methods: habitat-targeted acaricide (spraying), rodent-targeted acaricide (bait boxes), and white-tailed deer targeted acaricide (4-poster …

Sexual Behaviors Associated With Online Partner-Seeking Among Men Who Have Sex With Men From Small/Midsized Towns Or Rural Areas In Kentucky, Vira Pravosud

Theses and Dissertations--Epidemiology and Biostatistics

The HIV epidemic remains one of the most significant public health issues in the United States, particularly among men who have sex with men (MSM). New avenues for partner-seeking have emerged over the past three decades, including through the Internet, social media, and geosocial networking applications. Consisting of three cross-sectional studies, this dissertation research aimed to determine associations between the use of various online tools for partner-seeking (hereafter collectively referred to as “apps”) and HIV-related sexual behaviors among 252 young adult MSM residing in small/midsized towns or rural areas in Central Kentucky, a group that has been under-represented in the …

Maternal Proximity To Mountaintop Removal Mining And Birth Defects In Appalachian Kentucky, 1997-2003, Daniel B. Cooper

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background: Extraction of coal through mountaintop removal mining (MTR) alters many dimensions of the landscape, and explosive blasts, exposed rock, and coal washing have the potential to pollute air and water with substances known to increase risk of developmental and birth anomalies. Previous research suggests that infants born to mothers living in MTR coal mining counties have higher prevalence of most types of birth defects.

Objectives: This study seeks to examine further the relationship between MTR activity and birth defects by employing individual level exposure estimation through precise satellite data of MTR activity in the Appalachian region and maternal residence …

Bisphosohoglycertae Mutase: A Potential Target For Sickle Cell Disease, Anfal S. Aljahdali

Theses and Dissertations

Bisphosphoglycerate mutase (BPGM) is a part of the erythrocyte glycolysis system. Specifically, it is a central enzyme in the Rapoport-Leubering pathway, a side glycolytic pathway involved in the regulation of the concentration of the natural allosteric effector of hemoglobin (Hb), 2,3-bisphosphoglycerate (2,3-BPG). BPGM catalyses the synthesis and hydrolysis of 2,3-BPG through its synthase and phosphatase activities. The synthase activity is the main role of BPGM, while the phosphatase activity is low and is activated by the physiological effector, 2-phosphoglycolate (2-PG) with the latter mechanism poorly understood.

BPGM activity and 2,3-BPG levels in red blood cells (RBCs) have a significant role …

The Need To Incorporate Communities In Compartmental Models, Michael J. Kane, Owais Gilani

Faculty Journal Articles

Tian et al. provide a framework for assessing population- level interventions of disease outbreaks through the construction of counterfactuals in a large-scale, natural experiment assessing the efficacy of mild, but early interventions compared to delayed interventions. The technique is applied to the recent SARS-CoV-2 outbreak with the population of Shenzhen, China acting as the mild-but-early treatment group and a combination of several US counties resembling Shenzhen but enacting a delayed intervention acting as the control. To help further the development of this framework and identify an avenue for further enhancement, we focus on the use and potential limitations of compartmental …

Design, Synthesis, And Anticancer Properties Of Ru(Ii) Complexes With Organometallic, “Expanded” Bipyridine, And O,O’-Chelating Ligands, Raphael Ryan

Theses and Dissertations--Chemistry

Cancer is a worldwide public health crisis that requires new and improved drugs to be developed to extend survival rates and improve quality of life for the patient. Platinum-based drugs are used in approximately 50% of cancer treatment regimens. These drugs are highly effective in many kinds of cancer; however, cancers can develop platinum resistance and these drugs have troubling side effects that reduced their use and efficacy. To overcome these disadvantages, many other metals have been studied for their anticancer properties. Notably, the anticancer properties of ruthenium-based agents have drawn considerable attention with multiple ruthenium complexes entering clinical trials. …

Modeling Coupled Disease-Behavior Dynamics Of Sars-Cov-2 Using Influence Networks, Juliana C. Taube

Honors Projects

SARS-CoV-2, the virus that causes COVID-19, has caused significant human morbidity and mortality since its emergence in late 2019. Not only have over three million people died, but humans have been forced to change their behavior in a variety of ways, including limiting their contacts, social distancing, and wearing masks. Early infectious disease models, like the classical SIR model by Kermack and McKendrick, do not account for differing contact structures and behavior. More recent work has demonstrated that contact structures and behavior can considerably impact disease dynamics. We construct a coupled disease-behavior dynamical model for SARS-CoV-2 by incorporating heterogeneous contact …

Raw And Pure Education In The Society, Iwasan D. Kejawa Ed.D

Department of Educational Administration: Dissertations, Theses, and Student Research

What does education mean to individuals in the world today? Education is a way one can attain or improve his or her ability to lead and survive in the society of ours. Without educational training of the mind, it may be impossible to realize the importance of adaptability of living in the environment. Without education, It may also be difficult to embellish the use of both the mental and physical attributes possessed by individual beings.

What really is education? Education is the training of the mind to perform desire functions or to perpetuate the modality of obtaining an end or …

Legacy And Emerging Per- And Polyfluoroalkyl Substances : Analysis, Environmental Distribution, And Bioconcentration, Richard Anthony Brase

Legacy Theses & Dissertations (2009 - 2024)

Per- and polyfluoroalkyl substances (PFAS) constitute a broad class of anthropogenic chemicals that have been used in numerous industrial and consumer-product applications since the late 1940s. The environmental persistence of these compounds in combination with their widespread commercial use have led PFAS to be recognized as contaminants of concern on the global scale. Despite regulatory efforts calling for the decreased use of certain perfluorocarboxylic and -sulfonic acids referred to as “legacy” PFAS, these compounds continue to be detected in both environmental and biological matrices. Moreover, manufacturers have begun to replace the legacy PFAS with emerging alternatives for which the regulations …

Therapy And Medical Imaging Applications Of Focusing Polycapillary X-Ray Optics, Weiyuan Sun

Legacy Theses & Dissertations (2009 - 2024)

Focusing polycapillary optics yield high gains in intensity and increased spatial resolution for a variety of clinical, lab-based, synchrotron, or in situ analysis applications. In this dissertation we investigate the extension of two applications of focusing polycapillary optics. The first is the application of polycapillary optics in radiation therapy. This discussion includes measurements and calculation of dose for focused beam orthovoltage therapy. A system has been designed to investigate whether the polycapillary optics can produce an X-ray beam which can give more accurate dose painting due to the higher dose concentration at the focal spot. X-ray exposures were measured with …

Physician Remuneration Schemes, Psychiatric Hospitalizations And Follow-Up Care: Evidence From Blended Fee-For-Service And Capitation Models., Thyna Vu, Kelly K Anderson, Rose Anne Devlin, Nibene H Somé, Sisira Sarma

Epidemiology and Biostatistics Publications

Psychiatric hospitalizations could be reduced if mental illnesses were detected and treated earlier in the primary care setting, leading to the World Health Organization recommendation that mental health services be integrated into primary care. The mental health services provided in primary care settings may vary based on how physicians are incentivized. Little is known about the link between physician remuneration and psychiatric hospitalizations. We contribute to this literature by studying the relationship between physician remuneration and psychiatric hospitalizations in Canada's most populous province, Ontario. Specifically, we study family physicians (FPs) who switched from blended fee-for-service (FFS) to blended capitation remuneration …

The Origins Of Manufactured Dissent And The Efficacy Of Climate Change Narratives, Emma Elisabeth Giering

Graduate College Dissertations and Theses

The year of 2020 revealed many things about the fragility of socially constructed institutions and the public trust which grants such entities legitimacy, which is perhaps what reinvigorated social discourse surrounding the existential threat posed by climate change. Amid a pandemic, Americans watched wildfires engulf much of the west coast, environmental regulations unravel in the hands of the Trump administration, and Wall Street begin trading futures contracts on the U.S.’s water supply. Given the ever-expanding record of environmental travesties, how are citizens to respond, and from where should they derive their inspiration for response?

This thesis answers the above question …

An Investigation Into Employee Exposure To Environmental Tobacco Smoke Within Designated Smoking Areas In The Hospitality Industry, With An Analysis Of Legislative Compliance Of Said Designated Smoking Areas, Hannah Byrne

Masters

Background: Occupational exposure to environmental tobacco smoke (ETS) is still occurring in the hospitality industry and the instance of non-compliant smoking areas required investigation. A designated smoking area covered by a roof where more than 50% of the perimeter of that part is surrounded by one or more walls is deemed a non-compliant smoking area. This study aimed to gather evidence of non-compliances across Dublin, determine current employee exposure whilst also measuring PM2.5 concentrations within smoking areas as well as providing insight into possible immediate health effects of ETS exposure.

Methods: Seventy-five smoking areas (41 located in high, 27 in …

Carborane-Appended Levodopa For Prostate-Specific Membrane Antigen And Boron Neutron Capture Therapy, Alejandra Macias

Graduate Research Theses & Dissertations

A multi-step organic synthetic method to attach carborane cages to biocompatible organic compounds for application in Boron Neutron Capture Therapy (BNCT) was conducted. Boron Neutron Capture Therapy is a form of radiation therapy that promises a new and effective form of cancer treatment that involves the destruction of tumor cells using an isotope of boron (10B). The effectiveness of this therapy depends on the boron content accumulated in cancerous tissue. Carboranes are boron-rich clusters that possess unique physical and chemical properties making them suitable for a wide range of applications including medicinal chemistry. Because of their high boron content, carborane-appended …

Effect Of Mutation And Vaccination On Spread, Severity, And Mortality Of Covid-19 Disease, Dr Hossam Zawbaa, Hasnaa Osama, Ahmed El‐Gendy, Haitham Saeed, Hadeer S. Harb, Yasmin M. Madney, Mona Abdelrahman, Marwa Mohsen, Ahmed M.A. Ali, Mina Nicola, Marwa O. Elgendy, Ihab A. Ibrahim, Mohamed E.A. Abdelrahim

Articles

Coronavirus disease 2019 (COVID-19) has had different waves within the same country. The spread rate and severity showed different properties within the COVID-19 different waves. The present work aims to compare the spread and the severity of the different waves using the available data of confirmed COVID-19 cases and death cases. Real-data sets collected from the Johns Hopkins University Center for Systems Science were used to perform a comparative study between COVID-19 different waves in 12 countries with the highest total performed tests for severe acute respiratory syndrome coronavirus 2 detection in the world (Italy, Brazil, Japan, Germany, Spain, India, …

Active Learning Strategy For Covid-19 Annotated Dataset, Amril Nazir, Ricky Maulana Fajri

All Works

The efficient diagnosis of COVID-19 plays a key role in preventing its spread. Recently, many artificial intelligence techniques, such as the deep neural network approach, have been implemented to help efficient diagnosis of COVID-19. However, the accurate performance of deep learning depends on the tuning of many hyperparameters and a large amount of labeled data. This COVID-19 data bottleneck also leads to insufficient human resources for data labeling, which presents a challenging obstacle. In this paper, a novel discriminative batch-mode active learning (DS3) is proposed to allow faster and more effective COVID-19 data annotation. The framework specifically designed to suit …

Sars-Cov-2 Exposure In Wild White-Tailed Deer (Odocoileus Virginianus), Jeffrey C. Chandler, Sarah N. Bevins, Jeremy W. Ellis, Timothy J. Linder, Rachel M. Tell, Melinda Jenkins-Moore, J. Jeffrey Root, Julianna B. Lenoch, Suelee Robbe-Austerman, Thomas J. Deliberto, Tom Gidlewski, Mia Kim Torchetti, Susan A. Shriner

United States Department of Agriculture Wildlife Services: Staff Publications

Widespread human SARS-CoV-2 infections combined with human–wildlife interactions create the potential for reverse zoonosis from humans to wildlife. We targeted white-tailed deer (Odocoileus virginianus) for serosurveillance based on evidence these deer have angiotensin-converting enzyme 2 receptors with high affinity for SARS-CoV-2, are permissive to infection, exhibit sustained viral shedding, can transmit to conspecifics, exhibit social behavior, and can be abundant near urban centers. We evaluated 624 prepandemic and postpandemic serum samples from wild deer from four US states for SARS-CoV-2 exposure. Antibodies were detected in 152 samples (40%) from 2021 using a surrogate virus neutralization test. A subset of samples …

Impact Of Covid-19 On The Us And Texas Economy: A General Equilibrium Approach, Lirong Liu, Steven S. Shwiff, Stephanie A. Shwiff, Maryfrances Miller

United States Department of Agriculture Wildlife Services: Staff Publications

This paper examines the impact of COVID-19 on the US and Texas economy using a computable general equilibrium model, REMI PI+. We consider three scenarios based on economic forecasts from various sources, including the University of Michigan’s RSQE (Research Seminar in Quantitative Economics), IMF, and the Wi orld Bank. We report a GDP loss of $106 million (a 6% decline) with 1.2 million jobs lost (6.6%) in Texas in 2020. At the national level, GDP loss is $996 billion (a 5% decline) with 11.5 million jobs lost (5.5%) in the same year. By 2026, the aggregate total GDP loss in …

Allometric Regression Of Snake Body Length From Head Image Measurements, Shane R. Siers

United States Department of Agriculture Wildlife Services: Staff Publications

As in many fields of wildlife research and management, camera devices and photogrammetry have become an integral part of the toolkit for exploring otherwise‐unseen aspects of the biology, behavior, and control of the invasive brown treesnake (Boiga irregularis) on Guam. Because brown treesnakes are cryptic and nocturnal, and nearly all aspects of their ecology are influenced by snake size, methods are needed to estimate snake size from images captured by infrared wildlife cameras. Unfortunately, it is difficult to capture images of an entire snake’s length at a controlled distance from a simple camera setup. Here, I describe the …

Environmental Dna For Conservation, Antoinette J. Piaggio

United States Department of Agriculture Wildlife Services: Staff Publications

Biodiversity must be documented before it can be conserved. However, it may be difficult to document species with few individuals (Thompson, 2013; Goldberg et al., 2016), thus it requires a multitude of tools to detect species that occur in low numbers or are elusive (see the various chapters in this volume). One tool that has become useful for conservation efforts utilizes environmental DNA, which is DNA shed into the environment by organisms (eDNA; Taberlet et al., 2018). Typically this involves taking environmental samples such as soil, water, air, or using biological surrogates for sampling biodiversity (e.g. leeches, sponges, carrion flies, …

A Novel Technique To Improve Capture Success Of Common Ravens, Lindsey R. Perry, Terrah M. Owens, Zachary T. Slick, Jimmy Taylor, Jonathan B. Dinkins

United States Department of Agriculture Wildlife Services: Staff Publications

Traditional trapping techniques for common ravens (Corvus corax; raven) require significant effort, often produce low capture rates, and cannot be used in some situations. We designed a 3-m noose pole to secure ravens from nocturnal roost locations while using a strobe spotlight to temporarily disorient them. We collected measures of trapping efficiency and contrasted them with padded leghold traps also used in the study. We effectively implemented our noose pole method in July and August of 2018, 2019, and 2020 in the Baker and Cow Lakes sage-grouse (Centrocercus urophasianus) Priority Areas of Conservation in eastern Oregon, USA, which yielded trapping …