Physical Sciences and Mathematics Commons^™

Development Of Computational Tools To Target Microrna, Luo Song

Dissertations & Theses (Open Access)

MicroRNAs (a.k.a, miRNAs) play an important role in disease development. However, few of their structures have been determined and structure-based computational methods remain challenging in accurately predicting their interactions with small molecules. To address this issue, my thesis is to develop integrated approaches to screening for novel inhibitors by targeting specific structure motifs in miRNAs. The project starts with implementing a tool to find potential miRNA targets with desired motifs. I combined both sequence information of miRNAs and known RNA structure data from Protein Data Bank (PDB) to predict the miRNA structure and identify the motif to target, then I …

The Practical Applications Of Video Games Beyond Entertainment, Jack Martin

School of Professional Studies

Much of the attention directed toward video games is focused on their role as entertainment. However, researchers have found that video games can have other, more practical uses for society. This thesis is designed to examine three specific examples of the practical applications of video games: video games in education, video games as accessible technology, and the social uses of video games. This project is based on pre-existing research conducted by professionals studying the aforementioned subtopics. Anecdotal stories from educators, people with disabilities, and developers are also discussed. The thesis explores specific examples of video games being used practically, and …

Worst Time Being Poor? The Hunger Problem In U.S. During Covid-19 Pandemic, Yuanhang Hu

School of Professional Studies

Food insecurity is deeply rooted in American society during and before the COVID-19 pandemic. Food Insecurity usually associates with economic indicators, such as unemployment rate, income level, etc. Currently, there are two main tools to fight the war of hunger. The first one is the government food assistance programs. And the second one is food pantries from the private sectors of the community. Both tools are facing numerous challenges due to COVID-19. The purpose of this article is to provide rational reasons to persuade the government to enhance the benefits of the Supplemental Nutrition Assistance Program (SNAP) and use administrative …

How Museum Utilize Social Media On Communication, Jiake Han

School of Professional Studies

With the development of Internet, social media became more and more popular among people. Many industries realize the importance of social media in business. Traditionally, museum concentrates more on personal visual experience, which is hard to be replaced by online media. However, museums now also put more concentrate on social media platform because it expands the way of engagement. Especially, for Coronavirus, many organizations including museums have to close. Therefore, museums have to depend more on social media platforms to communicate with audiences. This research aims at finding how different kind of social media help museum communicate and engage with …

A Web-Based Ai Assistant Application Using Python And Javascript, Viet Le, Tej Bahadur, Jainee Shah, Roushan Ara

School of Professional Studies

Our research is mainly based on a chatbot which is powered by Artificial Intelligence. Nowadays, Artificial Intelligence assistants such as Apple’s Siri, Google’s Now and Amazon’s Alexa are currently fast-growing and widely integrated with many smart devices. These assistants are built with the primary purpose of being personal assistants for every individual user in certain contexts. In this research, we would highlight the development process of the chatbots, features, problems, case studies and limitations.

This research delivers the information, helps developers to build answer bots and integrate chatbots with business accounts. The aim is to assist users and allow transactions …

Narrowing The Wealth And Income Gap In Poland, China, And The United States, Cyndy Carboo, Zhiling Song, Jiawei Feng, Xudong Zhu

School of Professional Studies

With the widespread of globalization, the wealth gap continues to widen globally. Due to the enormous differences in national conditions and political systems of various countries, this article selects China, the United States, and Poland as the research objects, and uses a specific time unit as the benchmark, and mainly focuses on the four directions of medical care, education, job opportunities, and pensions. A reader could understand the correlation between the wealth gap and multiple factors deeply in this article. This article analyzes the impact of income disparity on these three countries and proposes solutions to help narrow the gap …

Transparency And Yielding Of Law Officers Reform (Taylor) Act Of 2020: Proposal For Police Reform, Marwa Alnaal, Matthew L. Anderson, Hannah Brier, Mollie Campbell, Rose Wine

School of Professional Studies

The Transparency and Yielding of Law Officers Reform Act of 2020 (TAYLOR) proposes an example bill for law enforcement reform. During the summer of 2020, the United States witnessed civilian demonstrations nationwide calling for a change to policing. Our proposal is hoping to heed that call, offering a foundation for change that police forces and localities across the United States can utilize to rebuild trust and accountability.

The goal of the TAYLOR Act is not to defund the police; but rather, TAYLOR rethinks the priorities of the police. There can be no denying that the relationship of trust and security …

Cvs Covid-19 Screening Website: Test Automation, Savya Rawat

School of Professional Studies

CVS Pharmacy is an American retail corporation, also known as, and originally named, the Consumer Value Store owned by CVS Health, it is headquartered in Woonsocket, Rhode Island. CVS Pharmacy is currently the largest pharmacy chain in the United States by number of locations over 9,600 and total prescription revenue. CVS sells prescription drugs and a wide assortment of general merchandise, including over-the-counter drugs.

Now, coming to the reason why I have selected CVS pharmacy’s website cvs.com as my case study topic is because of CVS’s response to the covid-19 pandemic’s no-cost testing strategy. Whole of the world is suffering …

The Killingly Mascot Case Study, Jordan Lumpkins

School of Professional Studies

In the summer of 2019, in Killingly, Connecticut the local Board of Education voted to retire the "Redmen" mascot name it had used for nearly a century. This legislation was widely opposed and received extensive media coverage. Within a few months, the town experienced a massive political referendum where several local Board of Education members and Councilmen were replaced by single issue politicians promising to reinstate the "Redmen" name. Now holding a majority on the Board of Education, these Board members made Killingly the first school in U.S. history to reinstate a mascot after being deemed "derogatory."

It is the …

Healthy Food Portal Business Plan And Its Function Model, Alena Raupova

School of Professional Studies

Business planning is a tool of paramount importance in the process of company management, on the efficiency of which the future functioning of the enterprise depends. Formation of a business plan enables the team to productively and competently use existing funds and resources in their work and apply planning as a very effective management mechanism (Hamm, 2016).

The goal of this final project is to develop a business plan for a healthy nutrition portal for Bellyful LLC. Bellyful is based in Boston, USA, and the portal will be its first product. Our client is interested in researching the prospects of …

The Impact Of Special Interest Groups On The Federal Dietary Guidelines: Consequences For American Health, Dory Mcmillan

School of Professional Studies

This research paper explores the impact of relationships between lobbyists and both the USDA and HSS, and the impact these relationships have on the Dietary Guidelines for Americans that the agencies work together to create. The paper focuses specifically on the information the guidelines present in regard to red meat consumption, and the impacts this may have on American health, and healthcare costs associated. It was hypothesized that a relationship would be found between special interest groups and the U.S. Department of Health and Human Services and/or the U.S. Department of Agriculture. Research found there was a relationship between special …

Rcap Solutions Breach Management - Case Study, Eugene Adu-Gyamfi, Gio Al Muarrawi, Kwame Ofori

School of Professional Studies

Companies get hacked every day, and our in-scope company for this case study, RCAP Solution, was not an exception. Security incidents have increased both in volume and range in recent years, and cyber-attacks have become more sophisticated than ever before. There are so many reasons that drive this fact; one is that our infrastructure was not protected efficiently, but also attackers have become more knowledgeable in initiating advanced attacks at a scale. Additionally, the entrance of emerging technologies such as blockchain, machine learning, and the internet of things, added additional complexity to the already complex scene. Cybercriminals are using various …

Higher Education Responses To Crisis: A Case Study Of Clark University And The Pandemic Of 2020, Lisa Gillingham

School of Professional Studies

The COVID-19 pandemic has delivered an existential challenge to universities and other academic institutions at a time when they are already grappling with other weighty issues that may alter the fabric of higher education. COVID-19 has forced these institutions to consider and employ new ways of conducting its work with a sense urgency that is unprecedented in the recent history of the academy. The rate of learning around these models is rapid, and Higher Education is ripe for change.

Clark University has addressed the pandemic with a plan to protect and pivot using strategies that support the continuation of its …

Design And Synthesis Of Novel No-Drug Hybrid Compound And Green Catalytic Activity Evaluation Of Synthesized Silver Nanoparticles-Halloysite Nanocomposite, Majed Abdullah Bajaber

University of New Orleans Theses and Dissertations

Acetaminophen is a well-known analgesic that can manage pain and reduce fever. SCP-1 is a derivative of acetaminophen that showed significantly reduced hepatotoxicity and nephrotoxicity comparative to acetaminophen. Nitric oxides have been well known to play a key role in a wide variety of physiological and pathophysiological important processes. It was therefore of interest to synthesize a nitric oxide donor linked to SCP-1 that could have enhanced analgesic and antipyretic activity. A furoxan CAS 1609 as NO-donor was synthesized and linked to SCP-1 successfully. The furoxan CAS 1609 was initially synthesized from tetronic acid to give 1,2- dioxime in 86 …

Nuclear-Targeted Gold Nanoparticles Enhance The Effects Of Radiation Therapy With And Without Liposomal Delivery, Maureen Aliru

Dissertations & Theses (Open Access)

Less that 10% of pancreatic cancer patients are eligible for curative resection, and clinical trials evaluating chemoradiation in locally advanced patients with unresectable disease have been largely disappointing. New and creative therapeutic approaches are needed to address the unment need for treatment options. The objective of this thesis is to advance radiosensitization of treatment-resistant densely desmoplastic pancreatic cancer using nanoparticles to surmount biological barriers to effective particle distribution for DNA-targeting.

Clinical translation of radiosensitizing nanoparticles has stalled owing to technical challenges. Current strategies to use AuNPs for radiosensitization require large quantities of gold, kilovoltage x-rays, immediate irradiation after intravenous administration, …

Implementation Of An Electronic Alert For Improving Adherence To Diabetic Foot Exam Screenings In Type 2 Diabetic Patients In Primary Care Clinics, Ruby Denson

Student Scholarly Projects

Practice Problem: Patients with type 2 diabetes mellitus (T2DM) are at an increased risk of complications including foot ulcerations (Harris-Hayes et al., 2020). Preventive care is essential for the early detection of foot ulcers but despite the advantages of preventive screening, a limited number of primary care providers perform annual foot exams (Williams et al., 2018).

PICOT: The clinical question that guided this project was, “In adult patients with T2DM receiving care in a primary care setting, will the implementation of an electronic clinical reminder alert (ECR) increase provider adherence to performing an annual diabetic foot exam and risk …

Gardasil Vaccine Trends Within Nevada, California, And The U.S.: A Comparative Study, Karen S. Gutierrez

UNLV Theses, Dissertations, Professional Papers, and Capstones

Despite decreasing incidence in cervical cancer in the U.S., there continues to be an increase in public health concern for cervical cancer worldwide. Recent studies report that individuals are disproportionately affected based on region, sex, and race. Additionally, the human papillomavirus (HPV) attributable cancers may be reduced between 70% and 90% through the universal use of HPV-vaccines. In order to expand current knowledge and implement intervention programs in Nevada, it is critical to examine the associations among the Gardasil vaccine, cervical cancer screening, and adverse events following immunization as well as to understand the different socio-demographic subgroups affected. To our …

An Exploration Of The Numeracy Skills Required For Safe, Quality Nursing Practice, Anna Wendel

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to explore the numeracy skills required for safe, quality nursing practice. Using a descriptive mixed methods design, this study answered two research questions: 1) What numeracy skills do nurses perceive as important for providing safe, quality nursing care in the first three years of practice? 2) How do nurses incorporate numeracy skills into daily patient care during the first three years of practice? Early career nurses from a not-for-profit health care organization in the mid-Atlantic region of the United States (n=109) responded to an online survey tool developed by the student investigator that ranked …

Bivariate Markov Chain Model Of Irritable Bowel Syndrome (Ibs) Subtypes And Abdominal Pain, Ricardo Reyna Jr.

Theses and Dissertations

Researchers use stochastic models like continuous-time Markov chains (CTMC) to model progression of morbidities of public health impact, like HIV and Hepatitis C. Most of the research in that area is done for a single disease. In this research, we use a bivariate continuous-time Markov chain (CTMC) to model progression of co-morbidities. In particular, we use a bivariate CTMC to model the joint progression of Irritable Bowel Syndrome (IBS) and abdominal pain. Symptoms of IBS are known to change throughout the duration of the disorder. Hence, patients are normally asked to make a journal of the stool type, symptoms, and …

Towards Development Of A Remote Charting System For Connected Healthcare, Alex Bodurka

Masters Theses

Health Care Providers play a crucial role in a patients well-being. While their primary role is to treat the patient, it is also vital to ensure that they can spend adequate time with the patient to create a unique treatment plan and build a personal relationship with their patients to help them feel comfortable during their treatment. Health Care Providers are frequently required to manually record patient data to track their healthcare progress during their hospital stay. However, with hospitals continuously trying to optimize their workflows, this crucial one-on-one time with the patient is often not practical.

As a solution, …

Hyperpolarized Carbon-13 Magnetic Resonance Measurements Of Tissue Perfusion And Metabolism, Keith Michel

Dissertations & Theses (Open Access)

Hyperpolarized Magnetic Resonance Imaging (HP MRI) is an emerging modality that enables non-invasive interrogation of cells and tissues with unprecedented biochemical detail. This technology provides rapid imaging measurements of the activity of a small quantity of molecules with a strongly polarized nuclear magnetic moment. This polarization is created in a polarizer separate from the imaging magnet, and decays continuously towards a non-detectable thermal equilibrium once the imaging agent is removed from the polarizer and administered by intravenous injection. Specialized imaging strategies are therefore needed to extract as much information as possible from the HP signal during its limited lifetime.

In …

Evaluating The Reproducibility Of Physiological Stress Detection Models, Varun Mishra, Sougata Sen, Grace Chen, Tian Hao, Jeffrey Rogers, Ching-Hua Chen, David Kotz

Dartmouth Scholarship

Recent advances in wearable sensor technologies have led to a variety of approaches for detecting physiological stress. Even with over a decade of research in the domain, there still exist many significant challenges, including a near-total lack of reproducibility across studies. Researchers often use some physiological sensors (custom-made or off-the-shelf), conduct a study to collect data, and build machine-learning models to detect stress. There is little effort to test the applicability of the model with similar physiological data collected from different devices, or the efficacy of the model on data collected from different studies, populations, or demographics.

This paper takes …

Envrment: Investigating Experience In A Virtual User-Composed Environment, Matthew Key

Master's Theses

Virtual Reality is a technology that has long held society's interest, but has only recently began to reach a critical mass of everyday consumers. The idea of modern VR can be traced back decades, but because of the limitations of the technology (both hardware and software), we are only now exploring its potential. At present, VR can be used for tele-surgery, PTSD therapy, social training, professional meetings, conferences, and much more. It is no longer just an expensive gimmick to go on a momentary field trip; it is a tool, and as with the automobile, personal computer, and smartphone, it …

Phantom Ocean, Real Impact: Natural Surf Sound Experiments Alter Foraging Activity And Habitat Use Across Taxa, Ryan N. Wardle

Master's Theses

A growing body of research focuses on how background sounds shape and alter critical elements of animals’ lives, such as foraging behavior, habitat use, and ecological interactions (Bradbury & Vehrencamp, 2011; Barber et al., 2010; Kight & Swaddle, 2011; Shannon et al., 2016). Much of this research has centered on the effects of anthropogenic noise (Dominoni et al., 2020; Francis & Barber, 2013; Ortega, 2012; Swaddle et al., 2015), but recent studies have also revealed that natural sound sources can influence animal behavior (Davidson et al., 2017; Le et al., 2019). Natural sounds, such as crashing surf, can create conditions …

Stem Education In College: An Analysis Of Stakeholders’ Recent Challenges And Potential Solutions, Santanu De, Georgina Arguello

FDLA Journal

A vast majority of academic disciplines and curricula in the college center around Science, Technology, Engineering, and Mathematics (STEM), which are critical to developing the skills necessary for a global workforce. Rapid changes in pedagogical setups, educational modes, and advances in instructional technology entail diverse challenges for key stakeholders (i.e. students, faculty, and the organizations). This paper highlights the most relevant challenges and potential solutions in STEM higher education at the college level, reported in the last decade. The holistic analysis combining the three stakeholders’ perspectives would help elucidate significant contemporary aspects impacting the fields. The goal is to further …

When Will The Covid-19 Pandemic In Indonesia End?, Dewi Susanna

Kesmas

On January 30, 2020, the World Health Organization(WHO) declared 2019-nCOV to be a Public Health Emergency of International Concern (PHEIC), due to the significant increase in confirmed new cases in various countries.1 In Indonesia, the first confirmed COVID-19 case was a female who had a closed contact with the 24th confirmed case in Malaysia and the second case was the mother of the first case.2 As time goes by, the number of new cases has increased significantly, reaching 160.165 confirmed cases with 6,944 deaths by August 27, 2020.3 The time when the COVID-19 pandemic in Indonesia will end is not …

Assessment Of Knowledge, Attitudes, And Behaviors Of Turkish Women On Breast And Cervical Cancer In Karabük Province, Turkey, Nergiz Sevinc, Belgin Oral, Burcu Korkut

Kesmas

Breast and cervical cancer incidence and mortality among women have been increasing worldwide. This cross-sectional study aimed to evaluate women's knowledge, attitudes, and behaviors regarding breast and cervical cancers. The sample was composed of 507 women aged 18 years and older who were admitted to a primary health care center in Karabük, Turkey, from October to December 2019. The data was obtained using a questionnaire consisting of 34 questions regarding participants’ socio demographic characteristics, knowledge, attitudes, and behaviors toward breast and cervical cancers. The mean age of the participants was 41.3±12.0 years and 68.4% of them were married. Slightly more …

Ultraviolet Exposure And Photokeratitis Complaints Among Informal Welding Workers In Depok, West Java, Indonesia, Maria K I J Yustheresani, Fajaria Nurcandra, Azizah Musliha Fitri, Annisa Ika Putri, Dyah Utari

Kesmas

One of the photokeratitis risk factors is acute reversible radiation of ultraviolet (UV) rays, which injure the cornea's epithelial tissue. Informal welding workers are susceptible populations to UV rays exposure. This study aimed to confirm the influence of UV radiation exposure on photokeratitis complaints in welding workers in Cimanggis, Depok, West Java. A cross-sectional study was conducted from February to June 2019 and used to select 100 welding workers purposively. A semi-structured questionnaire was used to determine photokeratitis complaints, age, education level, eye protection, safety knowledge, and work period; the UV radiation measured by A UV meter. Data were analyzed …

Cultural And Religious Belief Approaches Of A Tuberculosis Program For Hard-To-Reach Populations In Mentawai And Solok West Sumatera, Indonesia, Rizanda Machmud, Irvan Medison, Finny Fitry Yani

Kesmas

Tuberculosis (TB) is a leading public health concern in Indonesia. It ranks second on the list of high-burden TB countries. In West Sumatra, 47% of TB cases are undetected, late diagnosed, and received incomplete treatment because of low-level awareness and knowledge and stigma, especially among the hardest to reach populations. The study aims to identify the best communication channel to reach those who live in vulnerable and remote areas. This study was a qualitative study applying in-depth interviews to the informal leaders, health officers, cultural artists, and religious leaders across districts in Mentawai and Solok Districts, which are remote and …

Policy Implementation: Teachers’ Role As First Responders In Emergencies And Disasters, Shabir Hyder, Adnan Fazal Manzoor, Muhammad Amjad Iqbal

Kesmas

During the past decade, the schoolchildren faced many disasters and emergencies originating from natural and man-made sources. The safety of schoolchildren rests with school management and teachers. This study aimed to assess teachers' awareness with regard to disaster prevention and health, safety, security, and environment (HSSE) policies at primary schools in Pakistan. In addition, it explores the suitability of teachers to perform as emergency handlers in the absence of school nurses and resource officers (SROs). The study involved a qualitative study, based on open-ended interviews from a sample of 25 school teachers. Methodology triangulation was applied to reduce bias. Results …