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Full-Text Articles in Physical Sciences and Mathematics

Ml-Medic: A Preliminary Study Of An Interactive Visual Analysis Tool Facilitating Clinical Applications Of Machine Learning For Precision Medicine, Laura Stevens, David Kao, Jennifer Hall, Carsten Görg, Kaitlyn Abdo, Erik Linstead May 2020

Ml-Medic: A Preliminary Study Of An Interactive Visual Analysis Tool Facilitating Clinical Applications Of Machine Learning For Precision Medicine, Laura Stevens, David Kao, Jennifer Hall, Carsten Görg, Kaitlyn Abdo, Erik Linstead

Engineering Faculty Articles and Research

Accessible interactive tools that integrate machine learning methods with clinical research and reduce the programming experience required are needed to move science forward. Here, we present Machine Learning for Medical Exploration and Data-Inspired Care (ML-MEDIC), a point-and-click, interactive tool with a visual interface for facilitating machine learning and statistical analyses in clinical research. We deployed ML-MEDIC in the American Heart Association (AHA) Precision Medicine Platform to provide secure internet access and facilitate collaboration. ML-MEDIC’s efficacy for facilitating the adoption of machine learning was evaluated through two case studies in collaboration with clinical domain experts. A domain expert review was also …


Synthesis Of Fluorinated Pyrazoles Via Intra- And Intermolecular Cyclization Reactions, Matthew Saucier May 2020

Synthesis Of Fluorinated Pyrazoles Via Intra- And Intermolecular Cyclization Reactions, Matthew Saucier

Honors Theses

Pyrazole-based pharmaceuticals treat a wide array of diseases and conditions including obesity, diabetes, cancer, microbial and viral infections, pain and inflammation, and many neurological disorders. Syntheses for this biologically significant substrate have been well developed, but current methods to afford fluorinated pyrazoles are limited by variability and selectivity. By 2013, over 25% of all drugs available on the market contained the element fluorine due to its unique characteristics leading to improved target protein binding, bioavailability, and metabolic stability. In order to harness these pharmaceutical benefits of fluorine and overcome its difficulty in handling and stability, we set out to develop …


Detection And Characterization Of Delta-9-Tetrahydrocannabinol And Novel Synthetic Cannabinoid Metabolites Using Human Liver Microsomes, Seema Murugan May 2020

Detection And Characterization Of Delta-9-Tetrahydrocannabinol And Novel Synthetic Cannabinoid Metabolites Using Human Liver Microsomes, Seema Murugan

Honors Theses

Marijuana and synthetic cannabinoids are the most commonly used and trafficked illicit drug. ∆9-tetrahydrocannabinol (THC) is the primary active compound in marijuana. Synthetic cannabinoids were created as a method to study the effects of cannabinoids on the endocannabinoid system, which consists of endogenous cannabinoids, cannabinoid receptors, and the synthetic and degrading enzymes responsible for the synthesis and degradation of endocannabinoids. Cannabinoids activate the same receptors as endocannabinoids. Synthetic cannabinoids gained popularity as recreational drugs due to their ability to avoid detection. Synthetic cannabinoids have been found to have a greater binding affinity to the cannabinoid CB1 receptor …


The Histone Deacetylase Inhibitor Largazole: A Potential Chemotherapeutic Agent, Hannah Lynn Carson May 2020

The Histone Deacetylase Inhibitor Largazole: A Potential Chemotherapeutic Agent, Hannah Lynn Carson

Honors Theses

Histone deacetylase enzymes are known for their inherent activity as epigenetic modifiers. Although, they have become recognized for their role in cancer progression and other diseases. But also, histone deacetylases have other non-histone targets, for example, microtubules, which play important roles in cancer metastasis, apoptosis, and replication. With histone deacetylase inhibitors (HDACi), our research explored HDACi effects on breast cancer cell lines. The overall goal was to understand the potential of largazole, a class one histone deacetylase inhibitor on breast cancer cell lines. The research consisted of two parts: sulforhodamine B (SRB) viability assays under hypoxic and normoxic conditions. The …


Study Of Pharmaceutical Tablets Using Raman Mapping, Kyle Joseph Pauly May 2020

Study Of Pharmaceutical Tablets Using Raman Mapping, Kyle Joseph Pauly

Honors Theses

Covalent bonds are the strongest type of bonds holding molecules together. Based on the pattern of bonding of the molecule, the atoms associated with the bond will vibrate at a specific frequency. Utilizing vibrational spectroscopy, such as Raman spectroscopy, these unique vibrational frequencies can be used to detect the presence of analytes over a selected area. Furthermore, the intensities of the vibrational modes can be tracked to comparatively quantify the concentration of analytes at various locations. This is a method of great importance due to its ability to compare pharmaceutical tablets synthesized with different techniques. Here, the presence and concentration …


Public Perspectives And Media Reporting Of Wolf Reintroduction In Colorado, Rebecca Niemiec, Richard E.W. Berl, Mireille Gonzalez, Tara Teel, Cassiopeia Camara, Matthew Collins, Jonathan Salerno, Kevin Crooks, Courtney Schultz, Stewart Breck, Dana Hoag May 2020

Public Perspectives And Media Reporting Of Wolf Reintroduction In Colorado, Rebecca Niemiec, Richard E.W. Berl, Mireille Gonzalez, Tara Teel, Cassiopeia Camara, Matthew Collins, Jonathan Salerno, Kevin Crooks, Courtney Schultz, Stewart Breck, Dana Hoag

United States Department of Agriculture Wildlife Services: Staff Publications

In the state of Colorado, a citizen ballot initiative to reintroduce gray wolves (Canis lupus) is eliciting polarization and conflict among multiple stakeholder and interest groups. Given this complex social landscape, we examined the social context surrounding wolf reintroduction in Colorado as of 2019. We used an online survey of 734 Coloradans representative in terms of age and gender, and we sampled from different regions across the state, to examine public beliefs and attitudes related to wolf reintroduction and various wolf management options. We also conducted a content analysis of media coverage on potential wolf reintroduction in 10 major daily …


A Review Of Major Role Of Vitamin D3 In Human Immune System And Its Possible Use For Novel Corona Virus Treatment, Florentin Smarandache, Victor Christianto May 2020

A Review Of Major Role Of Vitamin D3 In Human Immune System And Its Possible Use For Novel Corona Virus Treatment, Florentin Smarandache, Victor Christianto

Branch Mathematics and Statistics Faculty and Staff Publications

the evidences showing major role of Vitamin D3 in human immune system and its potential use for novel corona virus treatment. Our argument is based on research finding that corona virus has viral envelope glycoproteins. In this regard, Vitamin D3 proves to offer various beneficial effects, including immunomodulatory effect, in order to break the glycoproteins envelope of the virus. One of the greatest benefit of vitamin D3 is the fact that it is easy to get 10,000 - 20,000 IU of daily intake requirement, by sunbathing for more or less twenty minutes. Such a method is likely applicable in many …


Silicon Quantum Dots Conjunctive With Stable Radicals: Potential Application In Non-Invasive Cancer Diagnostics, Daylan R. Post May 2020

Silicon Quantum Dots Conjunctive With Stable Radicals: Potential Application In Non-Invasive Cancer Diagnostics, Daylan R. Post

Honors College Theses

Quantum Dots, and nanomaterials in general, are one of the most promising areas of current physical study, especially their potential medical uses. In this study we introduced Nitroxide free radicals into a Silicon Quantum Dot (SiQD) solution and conducted experiments on the modified SiQDs in order to characterize their physical properties. We gathered emission, excitation, absorption and electron spin resonance (ESR) spectra of both modified and unmodified SiQDs. Previous studies have shown the possibility of using proteins as markers for cancer detection. Our measurements show the potential of using the interaction between these protein markers and SiQDs as a form …


Surface-Enhanced Raman Spectroscopy For Cocaine Detection, Kiersten Jo Mead May 2020

Surface-Enhanced Raman Spectroscopy For Cocaine Detection, Kiersten Jo Mead

Chemistry

The detection of drugs of abuse using Raman spectroscopy is of particular interest to forensic researchers at the moment. Raman spectroscopy is highly specific, fast, non-destructive, and can be adapted for in-situ measurements, making it the ideal forensic technique. Researchers working under the guidance of Doctor Igor Lednev have been able to use UV resonance Raman spectroscopy to detect cocaine in oral fluid without the need for sample pretreatment. They were however unable to detect the cocaine at forensically relevant levels. To overcome this limitation, surface-enhanced Raman spectroscopy (SERS) was used in this proof of concept study for the detection …


A Case Study On The Best Practices Of The Facilitating Organization For Peer Recovery Support Services In The State Of New Hampshire, Maggie Ringey May 2020

A Case Study On The Best Practices Of The Facilitating Organization For Peer Recovery Support Services In The State Of New Hampshire, Maggie Ringey

School of Professional Studies

In working with the Facilitating Organization for Peer Recovery Support Services through Harbor Homes, I have found that the Recovery Community Organizations that receive support through the FO provide valuable services that help individuals that struggle with substance use disorder achieve and maintain long term sobriety and recovery. The RCOs throughout New Hampshire bridge gaps in services and treatments that are left untouched by traditional clinical methods and through regular check ins, participants at the RCOs have reported that the services provided resulted in positive outcomes in their lives. Throughout the course of this research, I found that the RCOs …


Infant Mortality In The United States: Socioeconomic Factors Predicting Infant Survival In Late Neo-Natal And Post Neo-Natal Infants From Birth Certificate Data, Mark Brunk-Grady May 2020

Infant Mortality In The United States: Socioeconomic Factors Predicting Infant Survival In Late Neo-Natal And Post Neo-Natal Infants From Birth Certificate Data, Mark Brunk-Grady

Theses and Dissertations

According to the Centers for Disease Control and Prevention, the infant mortality rate in the United States in 2018 was 5.6 deaths per 1000 live births. Infant mortality is defined as a child being born alive but dying before their first birthday. This study aimed to determine if adding socioeconomic factors to traditional predictive survival models improved the predictive power in terms of survival for late and post neonatal infants. Secondly, this study looked to develop a risk score to and predict which mothers would be classified as “High” or “Low” risk for infant death.

Data were analyzed from a …


Young People, Social Media, And Impacts On Well-Being, Andreana Nop May 2020

Young People, Social Media, And Impacts On Well-Being, Andreana Nop

School of Professional Studies

Millennials and Generation Z were born into an age where social media and digital technology have been integrated in nearly all aspects of their lives. While social media has proven to be a valuable communication tool in connecting with each other and sharing information, the long-term psychosocial effects are beginning to become more apparent as social media matures. This study analyzes what these effects are and how communication is impacted for these young people. It questions how young people can leverage social media and decrease harm. The study will be conducted through a literature review and analysis. Its goal is …


Age At Migration And The Risk Of Psychotic Disorders: A Systematic Review And Meta-Analysis., Kelly K. Anderson, Jordan Edwards May 2020

Age At Migration And The Risk Of Psychotic Disorders: A Systematic Review And Meta-Analysis., Kelly K. Anderson, Jordan Edwards

Epidemiology and Biostatistics Publications

OBJECTIVE: To conduct a systematic review and meta-analysis of the existing evidence on the association between age at migration and the risk of psychotic disorders.

METHODS: Observational studies were eligible for inclusion if they presented data on the association between age at migration and the risk of psychotic disorders among first-generation migrant groups. We used two random effects meta-analyses to pool effect estimates for each stratum of age at migration relative to (i) a native-born reference category and (ii) the youngest age stratum (0 to 2 years).

RESULTS: Ten studies met inclusion criteria, and five were included in the meta-analysis. …


Progression Magazine, 2020 Spring/Summer, Coastal Carolina University May 2020

Progression Magazine, 2020 Spring/Summer, Coastal Carolina University

Progression Magazine

Magazine of the College of Science at Coastal Carolina University.


Mathematical Modeling Of Nonlinear Dynamics Of Blood Hormones On The Regulatory System, Gabriela Urbina May 2020

Mathematical Modeling Of Nonlinear Dynamics Of Blood Hormones On The Regulatory System, Gabriela Urbina

Theses and Dissertations

We study a mathematical modeling of nonlinear dynamics of blood hormones, which includes glucose and insulin. On Chapter I, II, III and IV, we introduce this work, analyze an effect of the secreted insulin by the pancreatic beta cells and glucagon hormones and state concluding remarks, respectively. This model considers the time evolution of nonlinear dynamics of the equations for glucose, glucagon and insulin concentrations plus insulin and glucagon actions and the secreted insulin as a result of elevation of glucose in the blood plasma. Using both analytical and numerical procedures, we determine such quantities using different parameters for different …


Diversity And Inclusion In The Workplace; Benefits, Challenges And Strategies For Success, Margaret Leone May 2020

Diversity And Inclusion In The Workplace; Benefits, Challenges And Strategies For Success, Margaret Leone

School of Professional Studies

In this case study I have explored the topic of diversity and inclusion in the workplace and learned how it can transform a business. When D&I is a serious business strategy supported by senior management it can help recruit and retain top talent, increase profits, and unleash creativity among other benefits. It is important to have leadership that is inclusive so they can set the tone for their staff

This case study evaluates the D&I culture at The Children’s Study Home (CHS) and explores best practices for improvement. CHS is a non-profit human service agency in Western MA, that’s mission …


The Mental Health Of Black Men: Stabilizing Trauma With Emotional Intelligence, Davis Brandford May 2020

The Mental Health Of Black Men: Stabilizing Trauma With Emotional Intelligence, Davis Brandford

School of Professional Studies

The purpose of this study is to explore the relationship between the impact of historical trauma and barriers on African-American males and the effects of emotional intelligence in reducing traumatic experiences. This research study is based on previous research and studies that explores the historical review of African- American oppression, trauma in black males, and mental health in the African American community. This study will utilize the historical trauma and emotional intelligence theories to explore barriers that African Americans have experienced over time and the role emotional intelligence can play to reduce trauma. It also explores the relevance of historical …


Elder Isolation In Immigrant Communities, Jessica Da Silva May 2020

Elder Isolation In Immigrant Communities, Jessica Da Silva

School of Professional Studies

This paper examined loneliness, as a measurement of perceived social isolation, in older immigrant adults. Previous research shows that older adults are more likely to experience social isolation and loneliness. Both of which have a direct correlation with their overall health (Wilson & Molton, 2010, Cacioppo et al., 2002) and mortality rates (Holt-Lunstad et al, 2015). Another international study found that immigrants in particular are at a higher risk for experiencing loneliness (Government of Canada, 2018). In this study, 35 immigrants and non-immigrants participants answered a survey which included 20 questions from the UCLA Loneliness Scale Version 3 (Russel, 1996). …


Managing Burnout And Secondary Traumatic Stress In Human Service Organizations, Naomi Ingram May 2020

Managing Burnout And Secondary Traumatic Stress In Human Service Organizations, Naomi Ingram

School of Professional Studies

This Case Study explores how burnout and secondary traumatic stress impact staffing, service delivery, and organizational effectiveness in a human service agency. The Case Study is focused around Ascentria Care Alliance’s Children & Family Services in Massachusetts, which encompasses three foster care programs: the Unaccompanied Refugee Minor (URM), Division of Children’s Services (DCS), and Intensive Foster Care (IFC) programs. Both individual and organizational approaches are needed to most effectively address burnout and secondary traumatic stress. Individual workers need to build resilience factors such as self-compassion and mindfulness, set appropriate boundaries with clients, engage in ongoing training, support, consultation, and supervision, …


Becoming A Trauma Informed Care Organization, Katie Robery May 2020

Becoming A Trauma Informed Care Organization, Katie Robery

School of Professional Studies

The Brockton Area Mutli Services Inc or BAMSI is a private, non-profit human services organization providing services to adults and children with developmental disabilities, mental illness, behavioral health, and public health needs. Founded in 1975, BAMSI is in the business of “bringing people and services together.” BAMSI transforms lives by building the capacity of individuals, families, organizations, and communities to learn, thrive, and achieve their goals. BAMSI services promote the recovery, resiliency, and self-determination of the people we serve. As a human services leader, we strive to be the provider of choice. (Duffy, 2019) With an emphasis on respect and …


Crisis Communication And Executive Leadership: Ethical Shortcomings In Government, Daniel Davidoff May 2020

Crisis Communication And Executive Leadership: Ethical Shortcomings In Government, Daniel Davidoff

School of Professional Studies

This research thesis project is an analysis of how and why governments fail in their attempts at crisis communication. The hypotheses tested are: there exists a negative correlation between unethical leadership and successful crisis communication practices. And governments are more likely to experience these failures due to ethical disconnects in modern politics. Research includes a review of relevant academic literature regarding crisis communication theory, as well as the ethical framework that can be applied to that theory. Cases considered are Hurricane Katrina, the choking death of Eric Garner, and the COVID-19 global pandemic. The research project concludes with a recommendation …


Rest Homes: Their Value On Massachusetts Healthcare Continuum, Ronald Pawelski May 2020

Rest Homes: Their Value On Massachusetts Healthcare Continuum, Ronald Pawelski

School of Professional Studies

In Massachusetts, rest homes provide cost effective care for elderly residents in a community setting. Rest homes, however, are not well-understood and the rest home industry itself suffers greatly, not only from a lack of understanding of the services they provide, but also from the strain on their financial resources due to both competition from other healthcare options and insufficient reimbursement rates for residents’ care.

The paper explores the financial challenges facing the industry and outlines the data that speaks to the value of the rest home care option for both the residents themselves and Massachusetts state healthcare budget. It …


Dallas, Tx: The Staggering Wealth Gap, Macy Golman May 2020

Dallas, Tx: The Staggering Wealth Gap, Macy Golman

School of Professional Studies

In the summer of 2019, I had the privilege of serving as an AmeriCorps member with an organization called Equal Heart. One of Equal Heart’s main initiatives was to provide meals to children in underserved populations, to make sure that without school in session, these children would still be receiving food. Unfortunately, in many instances, without these meals, many of the children we served would likely not know when they would be eating their next fulfilling meal. There were certain pockets of Dallas that we would travel to everyday, places that were fifteen minutes maximum from my house, but places …


Development Of Fully Balanced Ssfp And Computer Vision Applications For Mri-Assisted Radiosurgery (Mars), Jeremiah Sanders May 2020

Development Of Fully Balanced Ssfp And Computer Vision Applications For Mri-Assisted Radiosurgery (Mars), Jeremiah Sanders

Dissertations & Theses (Open Access)

Prostate cancer is the second most common cancer in men and the second-leading cause of cancer death in men. Brachytherapy is a highly effective treatment option for prostate cancer, and is the most cost-effective initial treatment among all other therapeutic options for low to intermediate risk patients of prostate cancer. In low-dose-rate (LDR) brachytherapy, verifying the location of the radioactive seeds within the prostate and in relation to critical normal structures after seed implantation is essential to ensuring positive treatment outcomes.

One current gap in knowledge is how to simultaneously image the prostate, surrounding anatomy, and radioactive seeds within the …


Tri-State Mining District, Ecological System, And Human Health: Systematic Literature Review Analysis, Jihyun Jane Min May 2020

Tri-State Mining District, Ecological System, And Human Health: Systematic Literature Review Analysis, Jihyun Jane Min

Posters

Objective: Although extensive research exists on corrosive environments in the Tri-State Mining District (TSMD), there has been a lack of research on how such harmful effects in the TSMD could affect residents living in those areas. However, quite recently, such research regarding relationships between the health conditions of low-income residents and toxic elements in TSDM began to grow. Therefore, the increase of empirical studies means greater complexity of the findings that require a more intricate understanding.

Methods: To meet the necessity of the study, this research was conducted by an extensive systematic review of the literature on the harmful effects …


Early Detection Of Mild Cognitive Impairment With In-Home Sensors To Monitor Behavior Patterns In Community-Dwelling Senior Citizens In Singapore: Cross-Sectional Feasibility Study, Iris Rawtaer, Rathi Mahendran, Ee Heok Kua, Hwee-Pink Tan, Hwee Xian Tan, Tih-Shih Lee, Tze Pin Ng May 2020

Early Detection Of Mild Cognitive Impairment With In-Home Sensors To Monitor Behavior Patterns In Community-Dwelling Senior Citizens In Singapore: Cross-Sectional Feasibility Study, Iris Rawtaer, Rathi Mahendran, Ee Heok Kua, Hwee-Pink Tan, Hwee Xian Tan, Tih-Shih Lee, Tze Pin Ng

Research Collection School Of Computing and Information Systems

Background: Dementia is a global epidemic and incurs substantial burden on the affected families and the health care system. A window of opportunity for intervention is the predementia stage known as mild cognitive impairment (MCI). Individuals often present to services late in the course of their disease and more needs to be done for early detection; sensor technology is a potential method for detection.Objective: The aim of this cross-sectional study was to establish the feasibility and acceptability of utilizing sensors in the homes of senior citizens to detect changes in behaviors unobtrusively.Methods: We recruited 59 community-dwelling seniors (aged >65 years …


Hdr Brachytherapy For Skin Cancer Using H.A.M. Applicator, Timothy Richard Thatcher May 2020

Hdr Brachytherapy For Skin Cancer Using H.A.M. Applicator, Timothy Richard Thatcher

UNLV Theses, Dissertations, Professional Papers, and Capstones

Skin cancer is the most common type of malignancy affecting both men and women in the United States. A majority of these cases are nonmelanoma skin cancers (NMSC) such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The goal of any skin cancer treatment is to cure the lesion itself while also preserving function and optimizing superficial cosmesis. High dose rate (HDR) brachytherapy provides an alternative to superficial x-ray or electron beam for skin cancer treatment. Utilizing an Iridium 192 source soldered to the end of a wire, surface dose can be administered at predetermined positions with sharper …


The Relationship Between Tree Canopy And Social Capital On Physical Activity In Unlv Students, Melissa Bartshe May 2020

The Relationship Between Tree Canopy And Social Capital On Physical Activity In Unlv Students, Melissa Bartshe

UNLV Theses, Dissertations, Professional Papers, and Capstones

Despite the numerous health benefits, rates of physical activity are low, especially among the college student population. Neighborhood tree canopy is one aspect of the built environment that has been shown to positively impact physical activity. Social capital has also been correlated with higher rates of physical activity. The sprawling urban design and arid desert climate of Las Vegas pose unique challenges to both tree canopy and social capital. Additionally, the relationship between tree canopy, social capital, and physical activity is understudied in the college student population. The purpose of this study was to assess the relationship of tree canopy …


Physical Therapy Nontreatment Events With Primary Physical Therapist, Stephen Johnson May 2020

Physical Therapy Nontreatment Events With Primary Physical Therapist, Stephen Johnson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Physical therapy improves prognosis reduces stay and is generally helpful in aiding recovery from a wide range of ailments. Nontreatment rates occur for multiple reasons and are also related to the personalities of physical therapists.

Methods: We used data from a research project involving physical therapy at an acute care facility in our community. Our study focused on the retrospectively determined primary physical therapist for each patient. We used the chi-squared tests to compare nontreatment rates between days of the week and disease type and the reasons for nontreatment events. Repeated-measure models were used to evaluate the effect of …


A Biogeographical Assessment Of Arctic Marine Fungi, Bentley E. Simpson May 2020

A Biogeographical Assessment Of Arctic Marine Fungi, Bentley E. Simpson

Honors College

Marine fungi play a crucial role in recycling nutrients and channeling energy to higher trophic levels in the world oceans. Despite their critical role, their distributions and community composition, particularly in the Arctic, are largely unknown. This study reveals depth-related trends of abundance, diversity, and community composition of Arctic marine fungi through analysis of data obtained in the Tara Oceans expedition. With samples from surface (0-50 m), deep chlorophyll max (50-200 m), and mesopelagic (200-1000 m) depths, relative abundance, operational taxonomic unit (OTU) richness, and diversity were found to increase as a function of depth. Basidiomycota and Ascomycota were found …