Physical Sciences and Mathematics Commons^™

Scholars Day Program Of Events 2017, Carl Goodson Honors Program

Scholars Day

No abstract provided.

Effects Of Ankle Weights On Metabolic Response And Muscle Activity On A Lower Body Positive Pressure Treadmill 2017, Saige Hupman

Master's Theses

Lower body positive pressure (LBPP) treadmills are growing in popularity for rehabilitative use, as the benefits of exercising at partially supported body weight may induce faster recovery. It is unknown if there are certain practices that increase exercise intensity while maintaining positive effects of LBPP. Adding ankle weights when walking or running could increase intensity of rehabilitation programs while maintaining the comfort of supported body weight. PURPOSE: To measure metabolic response (VO2, RER, HR, Caloric expenditure), RPE, and lower limb electromyography (EMG) amplitudes of LBPP treadmill walking and running with and without ankle weights. METHODS: Sixteen participants (Age: 21.94 ± …

Characterizing Landscape-Scale Erosion Using 10be In Detrital Fluvial Sediment: Slope-Based Sampling Strategy Detects The Effect Of Widespread Dams, Lucas J. Reusser, Paul R. Bierman, Donna M. Rizzo, Eric W. Portenga, Dylan H. Rood

College of Engineering and Mathematical Sciences Faculty Publications

Concentrations of in situ 10Be measured in detrital fluvial sediment are frequently used to estimate long-term erosion rates of drainage basins. In many regions, basin-averaged erosion rates are positively correlated with basin average slope. The slope dependence of erosion allows model-based erosion rate estimation for unsampled basins and basins where human disturbance may have biased cosmogenic nuclide concentrations in sediment. Using samples collected from southeastern North America, we demonstrate an approach that explicitly considers the relationship between average basin slope and erosion rate. Because dams and reservoirs are ubiquitous on larger channels in the field area, we selected 36 undammed …

Synthesis Of Two Tripeptide Intermediates Of Linear Hexapeptide Fragment Of Teixobactin.Docx, Edward Ramos

EGS Content

Pathogenic bacteria have become increasingly resistant to current antibiotics employed today to treat bacterial infections. While antimicrobial resistance increasingly threatens global health, the development of therapeutic agents with novel mechanisms of actions increases in demand. A recently discovered 11-amino acid depsipeptide known as teixobactin has exhibited potent antimicrobial activity against pathogenic bacteria. The pathogens subjected to teixobactin were not able to develop resistivity to the antimicrobial peptide. In this research, the synthesis of two tripeptide fragments of the linear hexapeptide fragment of teixobactin, Boc-D-Gln-D-allo-Ile-Ile-OR and Boc-N(Me)-D-Phe-Ile-Ser(OBn)-OBn were developed. HATU mediated peptide-coupling, benzylation, and EDCI/DMAP mediated esterification steps were employed in …

Umass Memorial Healthcare Information System Job Ladder, Matthew Simoncini, Vamsi Kavuru, Antariksh Nanda, Tahaseen Mahaboob Basha, Vikram Patil

School of Professional Studies

The capstone project report emphasizes the importance of a job ladder and the need of an hour to implement it at UMASS Memorial health care. The scope of this project is to create a well-established job ladder at UMASS with pre-defined standards on job levels related to Information Technology department that would facilitate in hiring, developing and promoting employees at various stages.

Somali National University, Sharmarke Abdulla, Nikala Pieroni, Jenna Caskie, Sergii Odnodvorets, Tanyue Gong, Lahari Dasari

School of Professional Studies

The executive summary presents an overview of the principal conclusions and recommendations for Somali National University Faculty of Education (FoEd) regarding the following concerns: Difficulty with recruiting high quality prospects to the FoEd; Ineffective and counterintuitive use of social media as a tool to improve brand equity, as well as as a tool to attract and communicate with prospective and current students; Unbalanced gender ratio of current student body; Absence of student services and student supports; Low student retention rate; Limited resources for academic advising; This document is the result of a Clark University School of Professional Studies Capstone Project.

Human Services Management (Hsm) Certificate Program Expansion To Western Massachusetts Feasibility Study, Paul Campbell, Patrick Deschenes, Maria Pacheco, Bradley Paul, Elizabeth Vittum, Jing Zhang

School of Professional Studies

One of the most popular cost-savings programs that the Providers’ Council currently offers its members is a Certificate in Nonprofit Human Service Management (HSM) provided in partnership with Clark University and Suffolk University. As human services providers are struggling to hire and retain qualified staff, the need to provide professional development opportunities to help grow and expand a skilled health and human services workforce is a critical issue facing nonprofit organizations and communities in Massachusetts. This feasibility study examines the viability of Providers’ Council and Clark University expanding its HSM Certificate Program to organizations and staff located in western Massachusetts. …

A Learning Framework For The Ywca Central Massachusetts, Dayna Ankermann, Manjushree Burdekar, Priyanka Joshi, Ying Song, Yumeng Chen, Xing Xie

School of Professional Studies

After meeting with the Director of Wellness and Health Equity at the YWCA Central Massachusetts (which will be referred to as the YWCA from here on out), we learned that as a non-profit gym and health center, it is heavily underfunded. The main focus of the project was to determine how to upkeep the facility while bringing in new customers with limited resources and budget. Due to the needs of the YWCA, our group focused on six aspects: revenue stream, donor retention, increasing membership, customer experience, social media marketing, and membership fee structure. After completing extensive research, we were able …

Simplified Reversed Chloroquines To Overcome Malaria Resistance To Quinoline-Based Drugs, Bornface Gunsaru, Steven J. Burgess, Westin Morrill, Jane X. Kelly, Shawheen Shomloo, Martin J. Smilkstein, Katherine May Liebman, David H. Peyton

Chemistry Faculty Publications and Presentations

Building on our earlier work of attaching a chemosensitizer (reversal agent) to a known drug pharmacophore, we have now expanded the structure-activity relationship study to include simplified versions of the chemosensitizer. The change from two aromatic rings in this head group to a single ring does not appear to detrimentally affect the antimalarial activity of the compounds. Data from in vitro heme binding and beta-hematin inhibition assays suggest that the single aromatic RCQ compounds retain activities against Plasmodium falciparum similar to those of CQ, although other mechanisms of action may be relevant to their activities.

Range-Wide Prevalence And Impacts Of Pseudocercosporella Inconspicua On Lilium Grayi And An Assessment Of L. Superbum And L. Michauxii As Reservoirs, Cindy L. Barrett

Electronic Theses and Dissertations

Lilium grayi (Gray’s Lily), a southern Appalachian endemic species, is threatened by a Lilium-specific fungal pathogen, Pseudocercosporella inconspicua. The disease is characterized by tan lesions that can cause early senescence, while also lowering seed production and viability. This project tested for P. inconspicua conidia and accessed health at nine locations. The disease was present and ubiquitous across the range of L. grayi. Through identification of P. inconspicua conidia in the field, L. superbum (Turk’s Cap Lily) was identified as an additional host, while L. michauxii (Michaux’s Lily) was disease-free. However, infection was inducible in both species. With …

Mri Analysis Of White Matter Myelin Water Content In Multiple Sclerosis: A Novel Approach Applied To Finding Correlates Of Cortical Thinning, Michael Dayan, Sandra M. Hurtado Rua, Elizabeth Monohan, Kyoko Fujimoto, Sneha Pandya, Eve M. Locastro, Tim Vartanian, Thanh D. Nguyen, Ashish Raj, Susan A. Gauthier

Mathematics and Statistics Faculty Publications

A novel lesion-mask free method based on a gamma mixture model was applied to myelin water fraction (MWF) maps to estimate the association between cortical thickness and myelin content, and how it differs between relapsing-remitting (RRMS) and secondary-progressive multiple sclerosis (SPMS) groups (135 and 23 patients, respectively). It was compared to an approach based on lesion masks. The gamma mixture distribution of whole brain, white matter (WM) MWF was characterized with three variables: the mode (most frequent value) m1 of the gamma component shown to relate to lesion, the mode m2 of the component shown to be associated with normal …

Statistical Methods For Two Problems In Cancer Research: Analysis Of Rna-Seq Data From Archival Samples And Characterization Of Onset Of Multiple Primary Cancers, Jialu Li

Dissertations & Theses (Open Access)

My dissertation is focused on quantitative methodology development and application for two important topics in translational and clinical cancer research.

The first topic was motivated by the challenge of applying transcriptome sequencing (RNA-seq) to formalin-fixation and paraffin-embedding (FFPE) tumor samples for reliable diagnostic development. We designed a biospecimen study to directly compare gene expression results from different protocols to prepare libraries for RNA-seq from human breast cancer tissues, with randomization to fresh-frozen (FF) or FFPE conditions. To comprehensively evaluate the FFPE RNA-seq data quality for expression profiling, we developed multiple computational methods for assessment, such as the uniformity and continuity …

Synthesis And In-Vitro Cell Viability/Cytotoxicity Studies Of Novel Pyrrolobenzodiazepine Derivatives, John M. Jarrett

Undergraduate Honors Theses

Pyrrolobenzodiazepines (PBDs) are a group of naturally occurring compounds that were discovered in the cultures of Streptomyces in the 1960s. Some natural PBDs discovered in these cultures, such as anthramycin and sibiromycin, were shown to possess a broad spectrum of anti-tumor activity. Since cancer is still a leading cause of death globally, the development of novel anti-proliferative derivatives of PBDs is essential for human welfare worldwide. Further synthesis and structure-activity relationship (SAR) studies of the parent natural products and their tetracyclic analogs will lead to the discovery of drug candidates. In this work, thirteen PBD analogues were synthesized using no …

Thermal And Developmental Ecology Of Pupfish, Cyprinodon, Alexander Jones

UNLV Theses, Dissertations, Professional Papers, and Capstones

Pupfish from the genus Cyprinodon are among the most endangered groups of fishes on the planet, with nearly 40% of species being threatened with extinction. These pupfishes are often assumed to be the most temperature tolerant of all fish, coping with temperatures as low as 0 °C and as high as 44 °C. However, conflicting data exist and certain measures of thermal tolerance are not markedly higher in pupfish compared to common game fish. Pupfish egg production and growth has been known to be hampered at temperatures well below what they apparently experience in nature. I addressed why eggs fail …

Evaluation Of A Fluorescence Method For Quantifying Bioaerosol Concentrations On Air Quality Filter Samples, Rachel Kolberg

UNLV Theses, Dissertations, Professional Papers, and Capstones

Airborne particulate matter (PM) in outdoor environments contains many components that cause adverse human health effects. The size of the particulates determine in what manner the particles would bypass the body’s defense mechanisms to enter the respiratory system and is directly related to their health impacts. Currently the United States Environmental Protection Agency is enforcing the National Ambient Air Quality Standards (NAAQS) to regulate the annual and 24-hour average concentrations of PM2.5 and PM10 in the air. PM2.5 are fine particles with aerodynamic diameter <2.5μm, small enough to reach the deepest parts of the bronchi and lungs. PM10 include PM2.5 and larger particles with aerodynamic diameter of 2.5-10μm. Both PM2.5 and PM10 contain multiple components from multiple sources. Bioaerosols are an important component of PM, but there is limited knowledge about how bioaerosols contribute to PM2.5 and PM10 concentrations. There is also a lack of research about the incidence and prevalence of disease caused by bioaerosols and about the limits of exposure to bioaerosol particulates. The main barrier to assess bioaerosol concentrations and health-related effects is the absence of quick and inexpensive methodology for quantifying bioaerosols. This study explored the feasibility of using fluorescence microscopy to quickly quantify bioaerosols in PM2.5 and PM10 collected on polycarbonate filters. Bioaerosols were stained with a DNA marker directly on a filter, followed by fixation, microscopic imaging, and automatic counting. The method was first validated using reference samples prepared by depositing different known concentrations of E. coli onto blank polycarbonate filters. The results indicated a linear response over two orders of magnitude (R2 = 0.9) and an accuracy within ±25%. E. coli were also deposited onto selected ambient PM10 and PM2.5 filter samples to determine if pre-loaded particles would interfere with bioaerosol imaging and counting. It was found that despite an increase in uncertainty (variability), the calibration slope remained within ±10% of unity for both PM2.5 and PM10 samples. Bioaerosol concentrations in ambient samples, as quantified by this method, were on average 14% higher for PM10 than for PM2.5 acquired concurrently in a desert environment of Las Vegas, Nevada. The application of this method to other types of compliance filters, such as Teflon filters and tapes of a Beta Attenuation Monitor (BAM) were also explored in this study. By means of a high-yield approach this method is expected to facilitate bioaerosol research, support exposure and health assessments, and help refine NAAQS for PM2.5 and PM10.

Does Educational Level Influence Postmenopausal Breast Cancer Mortality Among Asians In U.S.?, Sfurti Maheshwari

UNLV Theses, Dissertations, Professional Papers, and Capstones

Studies on mortality from postmenopausal breast cancer (PMBC) by education level have not shown consistent results among US women. For US Asians, often seen as a “model” minority in terms of affluence and education this relationship has never been studied despite PMBC being the most common cancer in the country.

We analyzed 2008-2012 California Vital Statistics data and population data from the American Community Survey 2012 to compute age and education adjusted mortality ratios using negative binomial regression model for White (as a reference category) and Asian women. In total 3,277,106 (80%) White women and 852,376 (20%) Asian women died …

A Rural And Urban Study Of The Food Environment In Select Nevada Geographies, Joseph Nickelson

UNLV Theses, Dissertations, Professional Papers, and Capstones

National and county level examination of urban and rural food environments has taken place, but primary validation of venue existence and in-venue data are lacking. The literature show disparities in access to healthy foods through low density of large grocers/supermarkets, low variety and quality of produce and higher prices for a healthy diet in rural versus urban geographies. Rural areas are of unique concern due to poor health indicators such as higher obesity rates, higher diabetes rates, lower incomes and lower educations than urban residents. The goal of this study was to explore differences in the community and consumer level …

A Unified Inter-Host And In-Host Model Of Antibiotic Resistance And Infection Spread In A Hospital Ward, Lester Caudill, Barry Lawson

Department of Math & Statistics Faculty Publications

As the battle continues against hospital-acquired infections and the concurrent rise in antibiotic resistance among many of the major causative pathogens, there is a dire need to conduct controlled experiments, in order to compare proposed control strategies. However, cost, time, and ethical considerations make this evaluation strategy either impractical or impossible to implement with living patients. This paper presents a multi-scale model that offers promise as the basis for a tool to simulate these (and other) controlled experiments. This is a “unified” model in two important ways: (i) It combines inter-host and in-host dynamics into a single model, and (ii) …

Determining The Effects Of Social Media Monitoring To Identify Potential Foodborne Illness In Southern Nevada, Lauren Diprete

UNLV Theses, Dissertations, Professional Papers, and Capstones

Foodborne illness, commonly referred to as food poisoning, affects an estimated 1 in 6 Americans every year, despite the fact that it is entirely preventable. Many cases of foodborne illness go unreported; however, better reporting leads to faster health department response and containment. Social media monitoring, using software to identify trends in social media posts, is a novel new tool that has been tested in a variety of public health fields with promising preliminary results. The Southern Nevada Health District (SNHD) has employed social media monitoring software to identify potential foodborne illness within Southern Nevada. The purpose of this study …

Detecting And Evaluating Therapy Induced Changes In Radiomics Features Measured From Non-Small Cell Lung Cancer To Predict Patient Outcomes, Xenia J. Fave

Dissertations & Theses (Open Access)

The purpose of this study was to investigate whether radiomics features measured from weekly 4-dimensional computed tomography (4DCT) images of non-small cell lung cancers (NSCLC) change during treatment and if those changes are prognostic for patient outcomes or dependent on treatment modality. Radiomics features are quantitative metrics designed to evaluate tumor heterogeneity from routine medical imaging. Features that are prognostic for patient outcome could be used to monitor tumor response and identify high-risk patients for adaptive treatment. This would be especially valuable for NSCLC due to the high prevalence and mortality of this disease.

A novel process was designed to …

Modeling Of Anticancer Drug Delivery By Temperature-Sensitive Liposomes, Vera Franziska Loeser

Theses and Dissertations

Cytotoxic anticancer drugs are used to treat cancer, particularly tumors. These drugs themselves do not distinguish between healthy and tumor cells and attack all of them. Consequently physicians and chemists investigate safer ways of delivery that minimize damage to healthy cells. One of these ways are liposomal formulations of the anticancer drugs. Liposomes are vesicles that encapsulate the drug to shield the healthy parts of the body from the toxicity of the drugs. Due to the abnormal structure of tumors, especially their leaky vasculature, these macromolecules are able to diffuse into the tumor tissue whereas the normal vasculature prevents them …

Letter To The Members Of The Georgia Academy Of Science, David L. Bechler

Georgia Journal of Science

This letter is an update and review of recent activities in the Georgia Journal of Science. As of 2016, the journal has gone from a hardcopy format to a digital format through Digital Commons/Bepress (http://digitalcommons.gaacademy.org/gjs/). As a result of this, individuals worldwide now have access to journal articles free and online. Manuscripts accepted for publication are now placed online after the final acceptance and editing is complete.

A review on 20 March 2017 of online download events involving publications in 2016 shows that, of the 21 publications (the annual meeting program was included as one publication), there were …

Volume 3, Full Contents

Butler Journal of Undergraduate Research

No abstract provided.

Table Of Contents

Butler Journal of Undergraduate Research

Front cover, a list of the article contents in this issue, and editorial information.

14th Annual Symposium Of The School Of Science, Engineering And Health, Messiah College

School of Science, Engineering & Health (SEH) Symposium

Welcome to the 14th Annual Symposium of the School of Science, Engineering and Health. This event continues a strong tradition showcasing student and faculty innovation, creativity and productivity in academic departments largely from within the School of Science, Engineering and Health.

Functional Human Grin2b Promoter Polymorphism And Variation Of Mental Processing Speed In Older Adults, Yang Jiang, Ming Kuan Lin, Gregory A. Jicha, Xiuhua Ding, Sabrina L. Mcilwrath, David W. Fardo, Lucas S. Broster, Frederick A. Schmitt, Richard J. Kryscio, Robert H. Lipsky

Behavioral Science Faculty Publications

We investigated the role of a single nucleotide polymorphism rs3764030 (G > A) within the human GRIN2B promoter in mental processing speed in healthy, cognitively intact, older adults. In vitro DNA-binding and reporter gene assays of different allele combinations in transfected cells showed that the A allele was a gain-of-function variant associated with increasing GRIN2B mRNA levels. We tested the hypothesis that individuals with A allele will have better memory performance (i.e. faster reaction times) in older age. Twenty-eight older adults (ages 65-86) from a well-characterized longitudinal cohort were recruited and performed a modified delayed match-to-sample task. The rs3764030 polymorphism was …

Estimating The Impact Of A Select Criteria Pollutant (Pm2.5) On Childhood Asthma In Florida, Shabnam Mehra

USF Tampa Graduate Theses and Dissertations

Asthma has been reported in children as a leading chronic illness in the US and around the world. It is also the third leading cause of hospitalization among children under the age of 15, and is also one of the most common causes of school absenteeism. Children are at higher risk of asthma attacks and they pose a higher burden on health care system. Nearly 20.6% of middle and high school children in Florida have been told they have asthma, this prevalence has grown over 3% from 2006 to 2012. Changes in air pollutant levels are often related to health …

Measuring Gender-Based Violence Attitude On Twitter, Goonmeet Bajaj, Tanvi Banerjee, Amir Hossein Yazdavar, Valerie L. Shalin, Amit Sheth

Symposium of Student Research, Scholarship, and Creative Activities Materials

This study examines social media to analyze communication patterns, specifically in the Gender-Based Violence domain. It explores the pragmatic content of tweets to categorize them into one of the following groups: Belief, Fact Reporting, or Other to determine the tweeting practices prevalent in this domain.

Legalization Of Gay Marriage And Its Impact On Military Stereotypes Of Homosexuals, Jasmine Moore

Symposium of Student Research, Scholarship, and Creative Activities Materials

Homosexuality has become a popular research topic in a variety of professional fields, and over the last decade has become a priority for the military. Since the implementation of the law repealing Don't Ask Don't Tell (DADT) researchers have questioned what effects repealing this law has had on the military as a whole. Particular attention has been spent on studying the attitudes and stereotypes about homosexuals after DADT was repealed. However, there is a lack of research examining how marriage equality affects society's stereotypes about homosexuals serving in the United States military.

It was hypothesized that participants that have personal …

Wright State University's Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts From Friday, April 21, 2017, Wright State University

Symposium of Student Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Annual Celebration of Research, Scholarship and Creative Activities on April 21, 2017.