Physical Sciences and Mathematics Commons^™

Charlton Fire Department Resident Expectations: Survey And Analysis, Natalie Omary, Jingxin Wen, Junchen Chen, Denis Kornev

School of Professional Studies

The Town of Charlton is located in the heart of the Massachusetts with a resident population of just under 14,000 people. The Charlton Fire Department serves the town for needs related to fire fighting, fire prevention, burning permits and inspection services along with emergency medical services. The Department has requested the assistance of the Clark University COPACE Capstone students in creating and conducting survey in order to get a sense of what the resident of the town know about the fire department and to better gauge their expectations about what the department can provide for them. The survey was formulated …

Cybersecurity Awareness Shrewsbury Public Schools, Brittany Crompton, David Thompson, Manuel Reyes, Xueyan Zhao, Xueke Zou

School of Professional Studies

In the 21st Century, technology reaches every aspect of our lives. As “digital citizens” we must be aware of the dangers both to our technological equipment and our personal information stored, transmitted, and processed on this equipment. The Cybersecurity Awareness curriculum developed for the Shrewsbury Public School district is designed to meet this need, as well as foster an interest in technology and ethical computer use.

Alternatives Unlimited Inc. Property Service Application, Jalpa Dave, Pennie Nataliya, Neelakshi Bali

School of Professional Studies

The purpose of this project is to propose Property service application to be enforced for documenting and managing the work orders raised throughout the residencies. The company is looking into an application that would facilitate to track and monitor the maintenance request received in a systematic order and ensuring priority work request is resolved within the set time frame. The project is to enhance the property service's work more efficiently as this will provide a high level of charge for the occupants by providing quicker response to their requests. The Objectives set to achieve for this project are realistic and …

Information Technology Proposal For The Town Of Spencer, Vijay Basava, Corey Kenyon, Mahdi Soltani

School of Professional Studies

The Town of Spencer came to us looking for a plan to build and maintain their own personal fiber network for connection between departments and to improve data security for important information. After assessing the existing landscape and determining the various paths forward, we created network diagrams and plans for the movement forward of this project.

After assessing a variety of plans, we found that a full single-mode fiber network would be the best system for the implementation in Spencer. While it was the highest cost, it also scored the highest in our assessment.

A Study On Automated Process For Extracting White Blood Cellular Data From Microscopic Digital Injured Skeletal Muscle Images, Bibek Karki

UNLV Theses, Dissertations, Professional Papers, and Capstones

Skeletal muscle injury is one of the common injuries caused by high-intensity sports activities, military related works, and natural disasters. In order to discover better therapies, it is important to study muscle regeneration process. Muscle regeneration process tracking is the act of monitoring injured tissue section over time, noting white blood cell behavior and cell-fiber relations. A large number of microscopic images are taken for tracking muscle regeneration process over multiple time instances. Currently, manual approach is widely used to analyze a microscopic image of muscle cross section, which is time consuming, tedious and buggy.

Automation of this research methodology …

Differences In Perceived Importance Of Preventative Services And Healthcare Provider Trust Among Hispanics, Jonathan James Gore

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Hispanic population varies greatly in their risk factors, health outcomes and access to care by country of origin, level of education and language dominance (Vega & Amaro, 1994) (Fiscella, Franks, Doescher, & Saver, 2002b). The differences within the Hispanic population also extend to their knowledge and attitudes toward health choices and maintenance, where they receive their health information, and what they access to meet their health care needs. Subpopulations within the Hispanic community as defined by language dominance and nativity must be understood as separate and distinct so that the health needs of each can be adequately addressed. The …

Creating A Dynamic, Multi-Purpose Correction For Multiple Geometries And Field Sizes To Account For Off-Axis And Asymmetric Backscatter With Varian Portal Dosimetry, Remy Manigold

UNLV Theses, Dissertations, Professional Papers, and Capstones

Intensity modulated radiation therapy and volumetric modulated arc therapy are increasingly common in radiation therapy due to their benefits of target conformity and normal tissue sparing. Due to the complexities of plan delivery and the precision required, the dose delivered must be accurately measured for quality assurance (QA). One of the most efficient ways to perform patient-specific QA when using clinical linear accelerators (linac) is to use an electronic portal imaging device (EPID). Amorphous silicon (aSi) Electronic Portal Imaging Devices (EPIDs) are attached to the linac and can provide real-time feedback with spatial resolution on the order of sub-millimeter pixel …

Impacts To Phytoplankton After The Establishment Of Quagga Mussels In Lake Mead, Nevada, Warren Bruce Turkett

UNLV Theses, Dissertations, Professional Papers, and Capstones

Quagga mussels (Dreissena rostriformis bugensis) are an invasive species that were discovered in Lake Mead in January of 2007, and rapidly spread throughout the lake. Quagga mussels are about the size of a fingernail, but are known to clog pipes, damage infrastructure and alter ecosystems. In large numbers, mussels can have a dramatic impact on an ecosystem by reducing the phytoplankton and potentially increasing toxin producing cyanobacteria. This research analyzed data collected from three separate basins in Lake Mead to determine if water quality characteristics that are commonly impacted by invasive mussels have changed. Transparency, chlorophyll-a, phytoplankton and zooplankton samples …

A Clinical Decision Support System For Malignant Pleural Effusion Analysis, Troy J, Vargason, Joshua Cohn, David Rios, Olivia Schultz, Joseph Cleary, Dennis Lau, Walker Land, J. David Schaffer, Yinglei Li, Chun-An Chou, Saba A. Syouri, Jagmohan S. Sidhu, Martha F. Nelson, Xingye Qiao

Justice & Well-Being Studies Faculty Scholarship

Pleural effusion occurs when fluid accumulates in the pleural cavity surrounding the lung. This condition is commonly caused by infection, but can also be associated with the presence of a metastatic tumor. Samples of pleural fluid are used to analyze the morphologies of mesothelial cells and can typically be used to make a diagnosis between benignity and malignancy. Atypical pleural effusion samples are not easily identified as benign or malignant due to a lack of differentiable visual features, and such a problem has a significant influence in clinicians' decision making. In this paper, the goal is to develop a clinical …

Analysis Of The Point Of Sales System At Tower Hill Botanical Garden And Suggested Courses Of Action, Brian Dunn, Keerthi Bandi, Chantal Kopwa Epse Kassa, F.N.U Shelly

School of Professional Studies

As Tower Hill Botanic Garden continues to improve on its operations and enhance the experience of its visitors and members, they are on a quest for a new Point-Of-Sale (POS) system that not only works with its existing hardware and interface with Raiser’s Edge, a smartcloud fundraising and relationship management software central to the garden’s operations but also, have a restaurant module and the capability of operating both in a wireless and hard-wired environment.

Developing An Online Database Of Experts For The Worcester Regional Chamber Of Commerce, Zikan Chen, Douglas Grey, Pranjal Shah

School of Professional Studies

The Worcester Regional Chamber of Commerce as part of their mission to attract business to the Worcester area, want to create an online searchable database of industry experts made up of faculty members of the Colleges and Universities in the Worcester area. This online database will be placed on the Worcester Regional Chamber of Commerce Higher Education – Business Partnership page on their website. The limitations placed on this request are that the Regional Chamber as of this moment have no monetary or Information Technologies resources to provide for the realization of this request.

The proliferation of as A Service …

Strategies Of Balancing: Regulation Of Posture As A Complex Phenomenon, Allison Leich Hilbun

Electronic Theses and Dissertations

The complexity of the interface between the muscular system and the nervous system is still elusive. We investigated how the neuromuscular system functions and how it is influenced by various perturbations. Postural stability was selected as the model system, because this system provides complex output, which could indicate underlying mechanisms and feedback loops of the neuromuscular system. We hypothesized that aging, physical pain, and mental and physical perturbations affect balancing strategy, and based on these observations, we constructed a model that simulates many aspects of the neuromuscular system. Our results show that aging changes the control strategy of balancing from …

Energy Management Mechanisms Employed At The Human-Material Interface Of Traditional And Minimalist Shod Running, Nadine M. Lippa

Dissertations

From recreational to elite athletes, greater than 50% of runners sustain overuse injuries each year, prompting substantial research efforts to identify causes of—and solutions to—the high injury rate. Different shoe types and material property degradation have been related to injury. Two popular footwear types are traditional shoes with thick graded soles and minimalist running footwear with thinner foam and/or non-graded soles. Notwithstanding 45 years of significant modifications to shoe design features, gained knowledge in kinesiology, and advanced technologies in polymer science, runner injury rates have not decreased and EVA foam has remained the primary running shoe midsole material since the …

Improving Ventricular Catheter Design Through Computational Fluid Dynamics, Sofy Hefets Weisenberg

Masters Theses

Cerebrospinal fluid (CSF) shunts are fully implantable medical devices that are used to treat patients suffering from conditions characterized by elevated intracranial pressure, such as hydrocephalus. In cases of shunt failure or malfunction, patients are often required to endure one or more revision surgeries to replace all or part of the shunt. One of the primary causes of CSF shunt failure is obstruction of the ventricular catheter, a component of the shunt system implanted directly into the brain's ventricular system. This work aims to improve the design of ventricular catheters in order to reduce the incidence of catheter obstruction and …

Integration Of Multi-Platform High-Dimensional Omic Data, Xuebei An

Dissertations & Theses (Open Access)

The development of high-throughput biotechnologies have made data accessible from different platforms, including RNA sequencing, copy number variation, DNA methylation, protein lysate arrays, etc. The high-dimensional omic data derived from different technological platforms have been extensively used to facilitate comprehensive understanding of disease mechanisms and to determine personalized health treatments. Although vital to the progress of clinical research, the high dimensional multi-platform data impose new challenges for data analysis. Numerous studies have been proposed to integrate multi-platform omic data; however, few have efficiently and simultaneously addressed the problems that arise from high dimensionality and complex correlations.

In my dissertation, I …

Walking To Recovery - The Effects Of Postsurgical Ambulation On Patient Recovery Times, Trent William Stethen

Chancellor’s Honors Program Projects

No abstract provided.

Using Poincaré And Coefficient Analyses To Assess Changes In Variability In Respiration As A Function Of Leptin Status, Sex, And Buprenorphine In Mice, Wateen Hussein Alami

Chancellor’s Honors Program Projects

No abstract provided.

Health In Your Hand: Assessment Of Clinicians’ Readiness To Adopt Mhealth Into Rural Patient Care, Bryan Weichelt

Theses and Dissertations

Introduction: Technology is as much rural as it is urban, but mobile health (mHealth) could have a unique impact on health and quality of life for rural populations. The adoption of mobile technologies has soared in recent decades leading to new possibilities for mHealth use. This project considers the impact of these technologies on rural populations. Specifically, it is focused on assessing the barriers of physicians and healthcare organizations to adopt mHealth into their care plans. Gaps in knowledge exist in assessing organizational readiness for mHealth adoption, the use of patient-reported data, and the impact on rural healthcare. This project …

Effects Of Drift, Selection And Gene Flow On Immune Genes In Prairie Grouse, Zachary Bateson

Theses and Dissertations

Fragmentation of natural habitats is related to population decline in many species. The resulting small and isolated populations are expected to lose genetic variation at a rapid rate, which reduces the ability to adapt to environmental change. One concern is that small populations are more susceptible to emerging pathogens due to the loss of variation at immune genes. My dissertation examined the relative effects of gene flow, genetic drift and selection on immune genes in prairie-chickens (Tympanuchus cupido), a species that has undergone drastic population declines across their range. In the first chapter, I examined how artificial gene flow through …

Inhibitions Of Gsk3Β Modulates Cell Death In Epithelial Ovarian Cancer, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Naeha Pathak

Faculty Works: BCES (1999-2023)

Epithelial ovarian cancer is one of the most common gynecological malignancies and the fifth most frequent cause of cancer death in women, affecting over 22,000 women annually. Nearly 15,500 affected women die from this disease annually, and chemoresistance from the commonly prescribed platinum-based drug, carboplatin, is a major contributor to this mortality rate. Previous studies have identified genes with CpG islands that are methylated and transcriptionally silenced in resistant epithelial ovarian cancer patients. One of these genes is GSK3β, an important regulator of apoptosis and cell growth in the Wnt pathway. Thus, understanding the role of GSK3β suppression in chemoresistance …

Does Gendered Language Have An Effect On You?, Andrew John Stambolie, Angella Valencia, Olivia Allbright

Scholars Day

Our study tested the effects of gender exclusive and gender inclusive language on males’ and females’ feelings of ostracism, motivation, identification, and their emotions.

Research has shown that being rejected or ignored can have negative psychological effects. (Stout & Dasgupta, 2011).

Ostracism is both the act being ignored and excluded. It includes directly differing with the individual, indicating his or her failings, as well as actively denying being associated with this individual. (Cheung & Choi, 2000).

Discrimination can be understood as a larger sociological component that includes ostracism. (Cheung & Choi, 2000).

Research Question: Does the use of gender-inclusive and …

Physical And Psychological Balancing Act: Is Stability Desirable?, Abby Huggins, Marley Zochert, Nate Shrader

Scholars Day

Recent studies have conveyed that the physical instability of a person would alter the way they thought about other people’s relationships and the traits people seek in romantic partners. These studies also show that cordial physical experiences can impact people’s views of relationship stability (Kille, Forest, & Wood, 2013).

Confessing love for a significant other while seated in an unstable condition can alter how they truly feel if they were to be sitting in a stable condition (Forest, Kille, Wood, & Stehouwer, 2015).

Similarly, one study showed that being in a position that makes someone feel uncomfortable can influence what …

The Role Of Gender And Emotions On Moral Hypocrisy, Jordan K. Raglin, Tye G. Boudra-Bland, Tristan B. Benzon

Scholars Day

Recent studies have shown that the emotions of anger and guilt have interesting effects on an individual’s moral hypocrisy. Anger increasing the likelihood that one will be hypocritical and guilt effectively neutralizes any hypocritical tendencies. (Polman & Ruttan, 2012)

We were keenly interested to see if we could duplicate these results at Ouachita and were also curious as to whether or not gender plays a role in how hypocritical a person will be.

We wanted to know if emotion or gender could negatively impact logical reasoning because if they do, we could keep this in mind while making judgments in …

Aberrant Dna Methylation: Implications In Racial Health Disparity, Xuefeng Wang, Ping Ji, Yuanhao Zhang, Joseph F. Lacomb, Xinyu Tian, Ellen Li, Jennie L. Williams

Department of Biomedical Engineering Faculty Publications

Background Incidence and mortality rates of colorectal carcinoma (CRC) are higher in African Americans (AAs) than in Caucasian Americans (CAs). Deficient micronutrient intake due to dietary restrictions in racial/ethnic populations can alter genetic and molecular profiles leading to dysregulated methylation patterns and the inheritance of somatic to germline mutations. Materials and Methods Total DNA and RNA samples of paired tumor and adjacent normal colon tissues were prepared from AA and CA CRC specimens. Reduced Representation Bisulfite Sequencing (RRBS) and RNA sequencing were employed to evaluate total genome methylation of 5’-regulatory regions and dysregulation of gene expression, respectively. Robust analysis was …

Animal Model Research: The Apples And Oranges Quandary, Kenneth J. Shapiro

Kenneth J. Shapiro, PhD

In this paper, I explore the premises underlying the problem of the evaluation of animal models. I argue that the presence of similarities and differences between the model and the modelled, although historically and currently a dominant antinomy framing evaluation, is not a bottom-line consideration. What is critical is 1) whether we learn and 2) whether we improve treatment through the animal model research. Similarity between model and modelled and the closely related concept of validity are not coterminus with these critical evaluative measures. In fact, differences between the model and modelled also can provide impetus to new understanding and …

Do Insect Outbreaks Reduce The Severity Of Subsequent Forest Fires?, Garrett W. Meigs, Harold S.J. Zald, John L. Campbell, William S. Keeton, Robert E. Kennedy

Rubenstein School of Environment and Natural Resources Faculty Publications

Understanding the causes and consequences of rapid environmental change is an essential scientific frontier, particularly given the threat of climate- and land use-induced changes in disturbance regimes. In western North America, recent widespread insect outbreaks and wildfires have sparked acute concerns about potential insect-fire interactions. Although previous research shows that insect activity typically does not increase wildfire likelihood, key uncertainties remain regarding insect effects on wildfire severity (i.e., ecological impact). Recent assessments indicate that outbreak severity and burn severity are not strongly associated, but these studies have been limited to specific insect or fire events. Here, we present a regional …

2016 - The Twenty-First Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Twenty-first Annual Symposium of Student Scholars, held on April 21, 2016. Includes abstracts from the presentations and posters.

Molecular Mechanism Of Protein Kinase Recognition And Sorting By The Hsp90 Kinome-Specific Cochaperone Cdc37, Dimitra Keramisanou, Adam Aboalroub, Ziming Zhang, Wenjun Liu, Devon Marshall, Andrea Diviney, Randy W. Larsen, Ralf Landgraf, Ioannis Gelis

Chemistry Faculty Publications

Despite the essential functions of Hsp90, little is known about the mechanism that controls substrate entry into its chaperone cycle. We show that the role of Cdc37 cochaperone reaches beyond that of an adaptor protein and find that it participates in the selective recruitment of only client kinases. Cdc37 recognizes kinase specificity determinants in both clients and nonclients and acts as a general kinase scanning factor. Kinase sorting within the client-to-nonclient continuum relies on the ability of Cdc37 to challenge the conformational stability of clients by locally unfolding them. This metastable conformational state has high affinity for Cdc37 and forms …

2016 Symposium Overview, Cedarville University

The Research and Scholarship Symposium (2013-2019)

Click the "Download" button in the top right corner to view the abstract booklet.

From Mollusks To Medicine: A Venomics Approach For The Discovery And Characterization Of Therapeutics From Terebridae Peptide Toxins, Aida Verdes, Prachi Anand, Juliette Gorson, Stephen Jannetti, Patrick Kelly, Abba Leffler, Danny Simpson, Girish Ramrattan, Mandë Holford

Publications and Research

Animal venoms comprise a diversity of peptide toxins that manipulate molecular targets such as ion channels and receptors, making venom peptides attractive candidates for the development of therapeutics to benefit human health. However, identifying bioactive venom peptides remains a significant challenge. In this review we describe our particular venomics strategy for the discovery, characterization, and optimization of Terebridae venom peptides, teretoxins. Our strategy reflects the scientific path from mollusks to medicine in an integrative sequential approach with the following steps: (1) delimitation of venomous Terebridae lineages through taxonomic and phylogenetic analyses; (2) identification and classification of putative teretoxins through omics …