Physical Sciences and Mathematics Commons^™

Optical Diagnostics – Spectropathology For The Next Generation, Malgorzata Baranska, Hugh Byrne

Articles

N/A

Regional Review: Reaching New Heights In The Region Spring 2015, Heather Garcia ,Editor

Regional Campuses Publications

No abstract provided.

2015 Annual Research Symposium Abstract Book, Trinity College, Hartford Connecticut

Science Symposia Abstracts

2015 annual volume of abstracts for science research projects conducted by students at Trinity College

Evaluating Breast Cancer Stem Cell Response To Antiangiogenic Therapy, Connor J. Holloway

Open Access Theses

Angiogenic inhibitors function by blocking tumor cell signals used to recruit host tissue vasculature to the tumor site, thereby depriving the cancer of the nutriment needed for further expansion. The development and implementation of angiogenic inhibitors in conjunction with standard chemotherapy agents has increased progression-free survival but not overall patient survival. It is hypothesized that chronic exposure to large doses of AAT drugs worsens hypoxic conditions within the tumor mass, selectively stimulating aggressive cancer stem cell populations to grow and proliferate. ^ In this study, the expression of the CSC biomarkers ALDH1, DLL1, and EpCAM were evaluated in breast cancer …

Perceptions Of Potable Water In Rajasthan’S Jodhpur And Barmer Districts, Melissa Spross

Independent Study Project (ISP) Collection

This paper looks at differences and similarities in various populations’ perceptions of safe drinking water (SDW) within Rajasthan (RJ), India, developing suggestions for future initiatives addressing the movement for safe drinking water for all. For this study, surveys were used; the survey was conducted in RJ, India, both in urban Jodhpur and in surrounding rural villages. To analyze the data, all the responses were entered into Excel format to discover patterns, themes and trends within four subtopics: access, storage, quality and cultural significance. The responses indicate that while a distinct water culture spans the geographic area, each different population retains …

Effects Of Cannabidiol On Contractions And Calcium Signaling In Rat Ventricular Myocytes, Ramez M. Ali, Lina T. Al Kury, Keun Hang Susan Yang, Anwar Qureshi, Mohanraj Rajesh, Sehamuddin Galadari, Yaroslav M. Shuba, Frank Christopher Howarth, Murat Oz

All Works

© 2015 Elsevier Ltd. Cannabidiol (CBD), a major nonpsychotropic cannabinoid found in Cannabis plant, has been shown to influence cardiovascular functions under various physiological and pathological conditions. In the present study, the effects of CBD on contractility and electrophysiological properties of rat ventricular myocytes were investigated. Video edge detection was used to measure myocyte shortening. Intracellular Ca2+ was measured in cells loaded with the Ca2+ sensitive fluorescent indicator fura-2 AM. Whole-cell patch clamp was used to measure action potential and Ca2+ currents. Radioligand binding was employed to study pharmacological characteristics of CBD binding. CBD (1μM) caused a significant decrease in …

Volume 07, Rachel C. Lombardi, Ben Osterhout, Lindsay Graybill, Rebecca E. Dey, Skyler T. Carpenter, Emma Beckett, Jason Ware, Mollie Andrews, James Bates, Landon Cooper, Tiffani Jeffries, Maria Wheaton, Dallas Price, Laura Kahler, Sarah Charlton, Anna Bultrowicz, Emily Spittle, Erin Godwin, Eamon Brokenbrough

Incite: The Journal of Undergraduate Scholarship

Introduction from Interim Dean Dr. Jennifer Apperson

Spatial Analysis of Potential Risk Factors Associated with Addition of Atlantic Coast Pipeline Through Virginia by Rachel C. Lombardi

"Delicate Matters with No Speaking," "Hope and Nothing," "Mono Duality" by Ben Osterhout

"Connect" Graphic Design Senior Project by Lindsay Graybill

Phenolic Acids in Brassicaceae Plants: Ovipositional Stimulants or Deterrents for Cabbage White Butterfly, Pieris Rapae? by Rebecca E. Dey And Skyler T. Carpenter

"Abecedarian Cards" by Emma Beckett, Jason Ware, And Mollie Andrews

Helvetica: A Type Specimen Book by James Bates, Landon Cooper, Tiffani Jeffries, And Maria Wheaton

“Things Left Behind” by Dallas …

Physio@Home: Exploring Visual Guidance And Feedback Techniques For Physiotherapy Exercises, Richard Tang, Xing-Dong Yang, Scott Bateman, Joaquim Jorge, Anthony Tang

Research Collection School Of Computing and Information Systems

Physiotherapy patients exercising at home alone are at risk of re-injury since they do not have corrective guidance from a therapist. To explore solutions to this problem, we designed Physio@Home, a prototype that guides people through pre-recorded physiotherapy exercises using realtime visual guides and multi-camera views. Our design addresses several aspects of corrective guidance, including: plane and range of movement, joint positions and angles, and extent of movement. We evaluated our design, comparing how closely people could follow exercise movements under various feedback conditions. Participants were most accurate when using our visual guide and multi-views. We provide suggestions for exercise …

Electron Penetration Range For Diverse Materials, Anne C. Starley, Lisa M. Phillipps, Jr Dennison

Posters

The penetration range of energetic electrons into diverse materials can be modeled approximately with a simple fit. This fit is a function of a single parameter, Nv, which describes the effective number of valence electrons. Using the Continuous-Slow-Down-Approximation (CSDA) for energy deposition in a material, a composite analytical formula has been developed which estimates the range or maximum penetration depth of incident electrons for energies from10 MeV with an uncertainty of

Image Enhancement Of Cancerous Tissue In Mammography Images, Richard Thomas Richardson

CCE Theses and Dissertations

This research presents a framework for enhancing and analyzing time-sequenced mammographic images for detection of cancerous tissue, specifically designed to assist radiologists and physicians with the detection of breast cancer. By using computer aided diagnosis (CAD) systems as a tool to help in the detection of breast cancer in computed tomography (CT) mammography images, previous CT mammography images will enhance the interpretation of the next series of images. The first stage of this dissertation applies image subtraction to images from the same patient over time. Image types are defined as temporal subtraction, dual-energy subtraction, and Digital Database for Screening Mammography …

A Study Of Access Control For Electronic Health Records, Sergio Vincent Senese

All Student Theses and Dissertations

The expansion between Information Technology and Healthcare has created many new options for both disciplines, as well as challenges. One of these topics is the Electronic Health Record (EHR) and the push for a universal record. A challenge for this topic is access control: how to keep patient’s personal health information secure, but at the same time accessible to all fields of healthcare and accomplish this within the federal privacy laws made by our government. This study focuses on the idea of a single EHR containing all the different medical information for all the areas of healthcare for a patient. …

Spectropathology For The Next Generation: Quo Vadis?, Hugh Byrne, Malgorzata Baranska, Gerwin J. Pupples, Nick Stone, Bayden Wood, Kathleen M. Gough, Peter Lasch, Phil Heraud, Josep Sulé-Suso, Ganesh Sockalingum

Articles

Although the potential of vibrational spectroscopy for biomedical applications has been well demonstrated, translation into clinical practice has been relatively slow. This Editorial assesses the challenges facing the field and the potential way forward. While many technological challenges have been addressed to date, considerable effort is still required to gain acceptance of the techniques among the medical community, standardise protocols, extend to a clinically relevant scale, and ultimately assess the health economics underlying clinical deployment. National and international research networks can contribute much to technology development and standardisation. Ultimately, large-scale funding is required to engage in clinical trials and instrument …

Electron Penetration Range For Diverse Materials, Anne C. Starley, Lisa M. Phillipps, J. R. Dennison

Anne Starley

Formative Research On An Instructional Design Theory For Virtual Patients In Clinical Education: A Pressure Ulcer Prevention Clinical Reasoning Case, Manon Maitland Schladen

CCE Theses and Dissertations

Despite advances in health care over the past decades, medical errors and omissions remain significant threats to patient safety and health. A large number of these mistakes are made by trainees, persons who are just beginning to build the case-based experiences that will transform them from novices to expert practitioners. Clinicians use both intuitive and deductive problem-solving skills in caring for patients and they acquire expertise in applying these skills through interaction with many and varied cases.

The contemporary heath care environment, with decreased lengths of stay for patients and reduced duty hours for trainees, makes getting optimal patient exposure …

45rd Annual Wku Student Research Conference, Student Research Council

Student Research Conference Select Presentations

See document below for project abstracts

Genetic Associations Of Ppargc1a With Type 2 Diabetes: Differences Among Populations With African Origins, Amanpreet K. Cheema, Tan Li, Juan P. Liuzzi, Gustavo G. Zarini, Mehmet T. Dorak, Fatma G. Huffman

Department of Biostatistics Faculty Publications

The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases and n = 116 controls) and African Americans (n = 124 cases and n = 122 controls) living in South Florida with and without T2D. Adjusted logistic regression indicated that both SNP rs7656250 (OR = 0.22, P = 0.005) and rs4235308 (OR = 0.42, P = 0.026) showed protective association with T2D in Haitian …

Dialectical Behavior Therapy For High Suicide Risk In Individuals With Borderline Personality Disorder: A Randomized Clinical Trial And Component Analysis, Marsha M. Linehan, Kathryn E. Korslund, Melanie S. Harned, Robert J. Gallop, Anita Lungu, Andrada D. Neacsiu, Joshua Mcdavid, Katherine Anne Comtois, Angela M. Murray-Gregory

Mathematics Faculty Publications

No abstract provided.

Teaching Of Biostatistics And Epidemiology In Medical Schools: How Do We Fare Compared With Developed Countries, Vijay Tiwari, Kuldeep Kumar, Sherin Raj

Kuldeep Kumar

Background Biostatistics is taught in almost all medical schools at the undergraduate and the postgraduate levels as a core course and is a prerequisite to epidemiology, public health and evidence-based medicine. However, it has to be taught in a different way in medical schools as compared with how it is taught to the students studying MSc (Biostatistics) or in the Statistics Department in universities. Objectives (1) To review the experience of teaching biostatistics in medical schools in India and compares the same with abroad (2) How best the curriculum can be designed as per the need of the medical students …

Do Zoos And Aquariums Promote Attitude Change In Visitors? A Critical Evaluation Of The American Zoo And Aquarium Study, Lori Marino, Scott O. Lilienfeld, Randy Malamud, Nathan Nobis, Ron Broglio

Nathan M. Nobis, PhD

Modern-day zoos and aquariums market themselves as places of education and conservation. A recent study conducted by the American Zoo and Aquarium Association (AZA) (Falk et al., 2007) is being widely heralded as the first direct evidence that visits to zoos and aquariums produce long-term positive effects on people’s attitudes toward other animals. In this paper, we address whether this conclusion is warranted by analyzing the study’s methodological soundness. We conclude that Falk et al. (2007) contains at least six major threats to methodological validity that undermine the authors’ conclusions. There remains no compelling evidence for the claim that zoos …

Binding-Induced, Turn-On Fluorescence Of The Egfr/Erbb Kinase Inhibitor, Lapatinib, James N. Wilson

James N Wilson

We report the photophysical properties, binding-induced turn-on emission, and fluorescence imaging of the cellular uptake and distribution of lapatinib, an EGFR/ERBB inhibitor. Lapatinib, a type II, i.e. inactive state, inhibitor that targets the ATP binding pocket of the EGFR family of receptor tyrosine kinases. DFT calculations predict that the 6-furanylquinazoline core of lapatinib should exhibit an excited state with charge transfer character and an S0 to S1 transition energy of 3.4 eV. Absorption confirms an optical tran- sition in the near UV to violet, while fluorescence spectroscopy shows that photoemission is highly sensi- tive to solvent polarity. The hydrophobicity of …

Conjugated Polymer Nanoparticles For Biological Labeling And Delivery, Eladio A. Mendez

FIU Electronic Theses and Dissertations

Cancer remains one of the world’s most devastating diseases, with more than 10 million new cases every year. However, traditional treatments have proven insufficient for successful medical management of cancer due to the chemotherapeutics’ difficulty in achieving therapeutic concentrations at the target site, non-specific cytotoxicity to normal tissues, and limited systemic circulation lifetime. Although, a concerted effort has been placed in developing and successfully employing nanoparticle(NP)-based drug delivery vehicles successfully mitigate the physiochemical and pharmacological limitations of chemotherapeutics, work towards controlling the subcellular fate of the carrier, and ultimately its payload, has been limited. Because efficient therapeutic action requires drug …

Gender Differences In Perceptions And Self-Reported Driving Behaviors Among Teenagers. (Poster), Gavin C. Barr Jr. Md, Kathleen E. Kane Md, Robert D. Barraco Md, Timarie Rayburg Do, Lauren Dugan Do, Chadd K. Kraus Do, Mph, Marna R. Greenberg Do, Mph, Facep, Valerie Rupp Rn, Bsn, Kimberly Hamilton, Bryan G. Kane Md

Robert D Barraco MD, MPH

No abstract provided.

Facile Methods For The Analysis Of Lysophosphatidic Acids In Human Plasma, Jialu Wang

Dissertations and Theses

Lysophosphatidic acid (LPA) influences many physiological processes, such as brain and vascular development. It is associated with several diseases including ovarian cancer, breast cancer, prostate cancer, colorectal cancer, hepatocellular carcinoma, multiple myeloma atherosclerotic diseases, cardiovascular diseases, pulmonary inflammatory diseases and renal diseases. LPA plasma and serum levels have been reported to be important values in diagnosing ovarian cancer and other diseases. However, the extraction and quantification of LPA in plasma are very challenging because of the low physiological concentration and similar structures of LPA to other phospholipids. Many previous studies have not described the separation of LPA from other phospholipids, …

Addressing Distress And Pain In Animal Research: The Veterinary, Research, Societal, Regulatory And Ethical Contexts For Moving Forward, Kathleen Conlee, Martin Stephens, Andrew N. Rowan

Andrew N. Rowan, DPhil

While most people recognize that biomedical scientists are searching for knowledge that will improve the health of humans and animals, the image of someone deliberately causing harm to an animal in order to produce data that may lead to some future benefit has always prompted an uncomfortable reaction outside the laboratory. However, proponents of animal research have usually justified the practice by reference to greater benefits (new knowledge and medical treatments) over lesser costs (in animal suffering and death). Given that one of the costs of animal research is the suffering experienced by the animals, the goal of eliminating distress …

The Minimization Of Research Animal Distress And Pain: Conclusions And Recommendations, Kathleen Conlee, Martin Stephens, Andrew N. Rowan

Andrew N. Rowan, DPhil

While the attention given to preventing, assessing, and alleviating pain in research animals has increased noticeably in recent decades, much remains to be done both in terms of implementing best practices and conducting studies to answer outstanding questions. In contrast, the attention to distress (particularly non-pain induced distress) has shown no comparable increase. There are many reasons for this discrepancy, including the conceptual untidiness of the distress concept, the paucity of pharmacological treatments for distress, and perceived lack of regulatory emphasis on distress. These are challenges that need to be addressed and overcome. This book is intended to help meet …

Spectral Gene Set Enrichment (Sgse), H Robert Frost, Zhigang Li, Jason H. Moore

Dartmouth Scholarship

Gene set testing is typically performed in a supervised context to quantify the association between groups of genes and a clinical phenotype. In many cases, however, a gene set-based interpretation of genomic data is desired in the absence of a phenotype variable. Although methods exist for unsupervised gene set testing, they predominantly compute enrichment relative to clusters of the genomic variables with performance strongly dependent on the clustering algorithm and number of clusters. We propose a novel method, spectral gene set enrichment (SGSE), for unsupervised competitive testing of the association between gene sets and empirical data sources. SGSE first computes …

Spring 2015

Scientia

Dean Koocher reveals six key questions guiding strategic planning at the college; Alumnus turns passion for sports and psychology into rewarding career; Associate Professor Paula Kagan on nursing, health care and social justice; New facilities excite and invigorate students and faculty; Lab notes; Psychology students, faculty and staff provide mental health services for high-need populations

Wikipedia And Medicine: Quantifying Readership, Editors, And The Significance Of Natural Language, James M. Heilman, Andrew G. West

Andrew G. West

BACKGROUND: Wikipedia is a collaboratively edited encyclopedia. One of the most popular websites on the Internet, it is known to be a frequently used source of healthcare information by both professionals and the lay public.

OBJECTIVE: This document quantifies: (1) The amount of medical content on Wikipedia, (2) the citations supporting Wikipedia’s medical content, (3) the readership of medical content, and (4) the quantity/characteristics of Wikipedia’s medical contributors

METHODS: Using a well-defined categorization infrastructure we identify medically pertinent English Wikipedia articles and links to their foreign language equivalents (Objective 1). With these, Wikipedia’s API can be queried to produce metadata …

Subclinical Atherosclerosis And Obesity Phenotypes Among Mexican Americans, Susan T. Laing, Beverly Smulevitz, Kristina Vatcheva, Mohammad H. Rahbar, Belinda M. Reininger, David D. Mcpherson, Joseph B. Mccormick, Susan P. Fisher-Hoch

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

Background

Data on the influence of obesity on atherosclerosis in Hispanics are inconsistent, possibly related to varying cardiometabolic risk among obese individuals. We aimed to determine the association of obesity and cardiometabolic risk with subclinical atherosclerosis in Mexican‐Americans.

Methods and Results

Participants (n=503) were drawn from the Cameron County Hispanic Cohort. Metabolic health was defined as <2 of the following: blood pressure ≥130/85; triglyceride ≥150 mg/dL; high‐density lipoprotein cholesterol <40 mg/dL (men) or <50 mg/dL (women); fasting glucose ≥100 mg/dL; homeostasis model assessment of insulin resistance value >5.13; or high‐sensitivity C‐reactive protein >3 mg/L. Carotid intima media thickness (cIMT) was measured. A high proportion of participants (77.8%) were metabolically unhealthy; they were more likely to be male, older, with fewer years of education, and less likely to meet daily recommendations regarding …

Vibrational Microspectroscopy For Cancer Screening, Fiona Lyng, Ines Ramos, Ola Ibrahim, Hugh Byrne

Articles

Vibrational spectroscopy analyses vibrations within a molecule and can be used to characterise a molecular structure. Raman spectroscopy is one of the vibrational spectroscopic techniques, in which incident radiation is used to induce vibrations in the molecules of a sample, and the scattered radiation may be used to characterise the sample in a rapid and non-destructive manner. Infrared (IR) spectroscopy is a complementary vibrational spectroscopic technique based on the absorption of IR radiation by the sample. Molecules absorb specific frequencies of the incident light which are characteristic of their structure. IR and Raman spectroscopy are sensitive to subtle biochemical changes …