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Articles 9151 - 9180 of 11827
Full-Text Articles in Physical Sciences and Mathematics
Altered Cholesterol Metabolism In Human Cancers Unraveled By Label-Free Spectroscopic Imaging, Shuhua Yue
Altered Cholesterol Metabolism In Human Cancers Unraveled By Label-Free Spectroscopic Imaging, Shuhua Yue
Open Access Dissertations
Despite tremendous scientific achievements, cancer remains the second leading cause of death in the United States. Metabolic reprogramming has been increasingly recognized as a core hallmark of cancer. My dissertation work identified novel diagnostic markers and therapeutic targets for human cancers through the study of cholesterol in cancer cells.
Enabled by label-free Raman spectromicroscopy, we performed the first quantitative analysis of lipogenesis at single cell level in human patient cancerous tissues. Our imaging data revealed an unexpected, aberrant accumulation of esterified cholesterol in lipid droplets of high-grade prostate cancer and metastases, but not in normal prostate, benign prostatic hyperplasia, or …
Articulatory Distinctiveness Of Vowels And Consonants: A Data-Driven Approach, Jun Wang, Jordan R. Green, Ashok Samal, Yana Yunusova
Articulatory Distinctiveness Of Vowels And Consonants: A Data-Driven Approach, Jun Wang, Jordan R. Green, Ashok Samal, Yana Yunusova
School of Computing: Faculty Publications
Purpose: To quantify the articulatory distinctiveness of 8 major English vowels and 11 English consonants based on tongue and lip movement time series data using a data-driven approach.
Method: Tongue and lip movements of 8 vowels and 11 consonants from 10 healthy talkers were collected. First, classification accuracies were obtained using 2 complementary approaches: (a) Procrustes analysis and (b) a support vector machine. Procrustes distance was then used to measure the articulatory distinctiveness among vowels and consonants. Finally, the distance (distinctiveness) matrices of different vowel pairs and consonant pairs were used to derive articulatory vowel and consonant spaces …
The Spatial Distribution Of Cancer Incidence In Fars Province: A Gis-Based Analysis Of Cancer Registry Data, Ali Goli, Mahbobeh Oroei, Mehdi Jalalpour, Hossein Faramarzi, Mehrdad Askarian
The Spatial Distribution Of Cancer Incidence In Fars Province: A Gis-Based Analysis Of Cancer Registry Data, Ali Goli, Mahbobeh Oroei, Mehdi Jalalpour, Hossein Faramarzi, Mehrdad Askarian
Civil and Environmental Engineering Faculty Publications
Background: Cancer is a major health problem in the developing countries. Variations of its incidence rate among geographical areas are due to various contributing factors. This study was performed to assess the spatial patterns of cancer incidence in the Fars Province, based on cancer registry data and to determine geographical clusters.
Methods: In this cross sectional study, the new cases of cancer were recorded from 2001 to 2009. Crude incidence rate was estimated based on age groups and sex in the counties of the Fars Province. Age standardized incidence rates (ASR) per 100,000 was calculated in each year. …
Mapping The Knowledge Economy Of Medicinal Plants In Northern Madagascar: Information And Resource Flow In Traditional Health Practices, Chanelle Adams
Mapping The Knowledge Economy Of Medicinal Plants In Northern Madagascar: Information And Resource Flow In Traditional Health Practices, Chanelle Adams
Independent Study Project (ISP) Collection
In the wake of pharmaceutical success with alkaloid compounds found in the Madagascar periwinkle (Catharanthus roseus), there has been increased attention towards identifying medicinal properties in the country’s rich flora. Both native and foreign companies seek profitable use of wild plant species found within Madagascar’s unique biodiversity. Many conservation organizations believe that the world’s forests in biological “hot spots” contain cures unknown to modern science and therefore, their preservation essential.
While the protection of these natural resources is important to Western medicine, it is even more vital for local people who depend on the forest as their primary …
Use Of Immersive Visualization For The Control Of Dental Anxiety During Dental Hygiene Treatment, Carmelo Padrino-Barrios
Use Of Immersive Visualization For The Control Of Dental Anxiety During Dental Hygiene Treatment, Carmelo Padrino-Barrios
Dental Hygiene Theses & Dissertations
Purpose: The purpose of this study was to determine the effectiveness of immersive visualization (IV) therapy, a technique that provides visual and stereoscopic display through the use of eyewear, in anxious patients during an oral prophylaxis. Methods: A convenience sample of thirty adults was enrolled. A split mouth design was utilized. Subjects were randomly divided into two groups: group A (use of IV for the right side of the mouth), and group B (use of IV for the left side of the mouth). Subjects received a full mouth oral prophylaxis (removal of supra and subgingival calculus and selective polishing), always …
Designing The Search Trial: Ph250b In Practice, Laura Balzer
Designing The Search Trial: Ph250b In Practice, Laura Balzer
Laura B. Balzer
No abstract provided.
The Santa Clara, 2013-09-26, Santa Clara University
The Santa Clara, 2013-09-26, Santa Clara University
The Santa Clara
No abstract provided.
The Challenge Of Early Inpatient Postpartum Depression Screening, Elizabeth A. Berger Do, John C. Smulian Md, Mph, Joanne Quiñones Md, Msce, Rory L. Marraccini Md, Amy Wu Bs, Elizabeth A. Smulian Bs, Sandra L. Curet Md
The Challenge Of Early Inpatient Postpartum Depression Screening, Elizabeth A. Berger Do, John C. Smulian Md, Mph, Joanne Quiñones Md, Msce, Rory L. Marraccini Md, Amy Wu Bs, Elizabeth A. Smulian Bs, Sandra L. Curet Md
John C Smulian MD, MPH
No abstract provided.
Participation In Perinatal Interventional Research: Which Characteristics Matter?, Hai-Yen T. Nguyen Md, Joanne Quiñones Md, Msce, Daniel G. Kiefer Md, Anita Kurt Phd, Rn, Felisa Saldutti, John C. Smulian Md, Mph
Participation In Perinatal Interventional Research: Which Characteristics Matter?, Hai-Yen T. Nguyen Md, Joanne Quiñones Md, Msce, Daniel G. Kiefer Md, Anita Kurt Phd, Rn, Felisa Saldutti, John C. Smulian Md, Mph
John C Smulian MD, MPH
No abstract provided.
Image Quality Of Energy-Dependent Approaches For X-Ray Angiography, Jesse Evan Tanguay
Image Quality Of Energy-Dependent Approaches For X-Ray Angiography, Jesse Evan Tanguay
Electronic Thesis and Dissertation Repository
Digital subtraction angiography (DSA) is an x-ray-based imaging method widely used for diagnosis and treatment of patients with vascular disease. This technique uses subtraction of images acquired before and after injection of an iodinated contrast agent to generate iodine-specific images. While it is extremely successful at imaging structures that are near-stationary over a period of several seconds, motion artifacts can result in poor image quality with uncooperative patients and DSA is rarely used for coronary applications.
Alternative methods of generating iodine-specific images with reduced motion artifacts might exploit the energy-dependence of x-ray attenuation in a patient. This could be performed …
Net Reclassification Index: A Misleading Measure Of Prediction Improvement, Margaret Sullivan Pepe, Holly Janes, Kathleen F. Kerr, Bruce M. Psaty
Net Reclassification Index: A Misleading Measure Of Prediction Improvement, Margaret Sullivan Pepe, Holly Janes, Kathleen F. Kerr, Bruce M. Psaty
UW Biostatistics Working Paper Series
The evaluation of biomarkers to improve risk prediction is a common theme in modern research. Since its introduction in 2008, the net reclassification index (NRI) (Pencina et al. 2008, Pencina et al. 2011) has gained widespread use as a measure of prediction performance with over 1,200 citations as of June 30, 2013. The NRI is considered by some to be more sensitive to clinically important changes in risk than the traditional change in the AUC (Delta AUC) statistic (Hlatky et al. 2009). Recent statistical research has raised questions, however, about the validity of conclusions based on the NRI. (Hilden and …
Fall 2013
Scientia
Exciting start to the year at CSH; Science program offers a college sneak peek for Southside youth; The math class you've been waiting for; Nursing Double Demon shares story of success; Lab notes; Accolades; Many Dreams, One Mission campaign for DePaul University
Faculty Fellows 2013-2014, Place
Faculty Fellows 2013-2014, Place
PLACE Historical Documents
This document provides biographies of PLACE faculty fellows at Linfield College for 2013-2014.
Place Related Courses 2013-2014, Place
Place Related Courses 2013-2014, Place
PLACE Historical Documents
This document includes a complete list of all the related courses for the PLACE program at Linfield College from 2013-2014.
Student Fellows 2013-2014, Place
Student Fellows 2013-2014, Place
PLACE Historical Documents
This document provides biographies of PLACE student fellows at Linfield College for 2013-2014.
Legacies Of War, Place
Legacies Of War, Place
PLACE Historical Documents
This document explains the PLACE theme at Linfield College for 2013-2014 (Legacies of War).
Structure, Theoretical Studies And Coupling Reactions Of Some New Cyclic Boronic Esters, Andrew Kuttler, Sravanthi Durganala, Albert Fratini, Alexander Morgan, Vladimir Benin
Structure, Theoretical Studies And Coupling Reactions Of Some New Cyclic Boronic Esters, Andrew Kuttler, Sravanthi Durganala, Albert Fratini, Alexander Morgan, Vladimir Benin
Chemistry Faculty Publications
The present report describes the X-ray structural and theoretical studies of some new pinacolboronate esters, and it also outlines the use of the target structures in Suzuki coupling reactions to produce new aromatic or heteroaromatic esters and amides. X-ray structural analysis of the studied compounds revealed that the pinacolborane ring's position with respect to the benzene ring varies, depending on the particular environment. An ortho-positioned carboxylic ester (methyl ester) causes a nearly perpendicular orientation of the pinacolborane unit with respect to the benzene ring, whereas an ortho-positioned amide (N,N-dimethylamide) causes the pinacolborane unit to orient itself nearly coplanar. A plausible …
Parental Environments And Interactions With Conspecifics Alter Salinity Tolerance Of Offspring In The Annual Medicago Truncatula, Brenna M. Castro, Ken S. Moriuchi, Maren L. Friesen, Mounawer Badri, Sergey V. Nuzhdin, Sharon Y. Strauss, Douglas R. Cook, Eric Von Wettberg
Parental Environments And Interactions With Conspecifics Alter Salinity Tolerance Of Offspring In The Annual Medicago Truncatula, Brenna M. Castro, Ken S. Moriuchi, Maren L. Friesen, Mounawer Badri, Sergey V. Nuzhdin, Sharon Y. Strauss, Douglas R. Cook, Eric Von Wettberg
College of Agriculture and Life Sciences Faculty Publications
Summary: Based on expectations of the stress-gradient hypothesis for conspecific interactions, stress-sensitive genotypes may be able to persist in stressful environments when positive interactions between individuals occur under stressful environments. Additionally, we test how parental environmental effects alter responses to stress and outcomes of conspecific interactions in stress. While the stress-gradient hypothesis focuses on plant growth, earlier flowering may provide stress avoidance in short-lived organisms. We studied responses to soil salinity and conspecific neighbour using genotypes of Medicago truncatula (Fabaceae) originating from saline or non-saline environments, utilizing seeds from parental plants grown in saline or non-saline environments. During the early …
Perceived Attitudes And Staff Roles Of Community Based Outpatient Clinics In Disaster Management, Pauline Antoinette Hodge-Hilton
Perceived Attitudes And Staff Roles Of Community Based Outpatient Clinics In Disaster Management, Pauline Antoinette Hodge-Hilton
Loma Linda University Electronic Theses, Dissertations & Projects
Objective: Natural and manmade disasters have claimed the lives of thousands of individuals in the US and caused billions of dollars in property damage. First responders carry the responsibility of disaster management, leaving other health care professionals such as medical clinic staff underutilized to support the clinic staff. We explored how medical and support staff in Community-based Outpatient VHA Clinics (CBOC) perceive their roles in disaster response, their attitudes about clinic readiness and continuity of care during disasters, and their ability to function in a post disaster environment.
Methods: A mixed method study was conducted to answer questions related to …
Associations Of Smoking Status And Serious Psychological Distress With Chronic Obstructive Pulmonary Disease, Ke-Sheng Wang, Liang Wang, Shimin Zheng, Long-Yang Wu
Associations Of Smoking Status And Serious Psychological Distress With Chronic Obstructive Pulmonary Disease, Ke-Sheng Wang, Liang Wang, Shimin Zheng, Long-Yang Wu
ETSU Faculty Works
Background: Chronic obstructive pulmonary disease (COPD) has been a major public health problem due to its high prevalence, morbidity, and mortality. Smoking is a major risk factor for COPD, while serious psychological distress (SPD) is prevalent among COPD patients. However, no study focusing on the effect of SPD on COPD has been so far conducted, while few studies have focused on the associations of SPD and behavioral factors with COPD by smoking status.
Objectives: This study aimed to examine the associations of SPD and behavioral factors (such as smoking and physical activity) with COPD.
Materials and Methods: Weighted logistic regression …
Analysis Of Subgroup Data Of Clinical Trials, Kao-Tai Tsai, Karl E. Peace
Analysis Of Subgroup Data Of Clinical Trials, Kao-Tai Tsai, Karl E. Peace
Biostatistics Faculty Publications
Large randomized controlled clinical trials are the gold standard to evaluate and compare the effects of treatments. It is common practice for investigators to explore and even attempt to compare treatments, beyond the first round of primary analyses, for various subsets of the study populations based on scientific or clinical interests to take advantage of the potentially rich information contained in the clinical database. Although subjects are randomized to treatment groups in clinical trials, this does not imply the same degree of randomization among sub-populations of the original trials. Therefore, comparisons of treatments in sub-populations may not produce fair and …
Never Smokers -- Are They More Sensitive To The Respiratory Health Effects Of Ambient Air Pollution?, Zuhair Saleh Natto
Never Smokers -- Are They More Sensitive To The Respiratory Health Effects Of Ambient Air Pollution?, Zuhair Saleh Natto
Loma Linda University Electronic Theses, Dissertations & Projects
Background: Several studies show an association between ambient particulate matter (PM) and all-cause mortality. The Adventist Health and Smog 1 (AHSMOG-1) study (N=6,338) has previously found associations between ambient air pollution and incident chronic obstructive pulmonary disease (COPD) using the spatial interpolation method from the three nearest fixed monitoring stations to residence and workplace. However, few studies have assessed the risk of death among disease specific subgroups such as those with COPD.
Objectives: The aims of this study were 1) to assess the effect of chronic exposure to ambient air pollutants on risk of all-cause mortality among persons with COPD …
Overcoming Shortage Of Pharmacists To Provide Pharmaceutical Services In Public Health Centers In Indonesia, Yuyun Yuniar, Max Joseph Herman
Overcoming Shortage Of Pharmacists To Provide Pharmaceutical Services In Public Health Centers In Indonesia, Yuyun Yuniar, Max Joseph Herman
Kesmas
Indonesia masih menghadapi keterbatasan jumlah apoteker di puskesmas, sehingga pihak pemerintah daerah dan puskesmas harus berupaya mengatasi permasalahan tersebut. Penelitian ini bertujuan untuk menggambarkan ketersediaan dan distribusi tenaga pelayanan kefarmasian di puskesmas serta permasalahan dan alternatif pemecahannya. Data diambil dari hasil Riset Fasilitas Kesehatan (Rifaskes) tahun 2011I. Data kuantitatif tentang tenaga pelayanan kefarmasian di puskesmas dianalisis secara deskriptif berdasarkan regional. Data kualitatif sebagai pendukung diperoleh melalui wawancara mendalam dengan bagian kepegawaian dinas kesehatan dan apoteker empat puskesmas di Kota Bogor dan Bekasi, 3 kemudian dianalisis dengan metode analisis tema. Hasil analisis menunjukkan bahwa Sulawesi memiliki persentase puskesmas dengan tenaga apoteker …
Beyond Climate-Smart Agriculture: Toward Safe Operating Spaces For Global Food Systems, Henry Neufeldt, Molly Jahn, Bruce M. Campbell, John R. Beddington, Fabrice Declerck, Alessandro De Pinto, Jay Gulledge, Jonathan Hellin, Mario Herrero, Andy Jarvis, David Lezaks, Holger Meinke, Todd Rosenstock, Mary Scholes, Robert Scholes, Sonja Vermeulen, Eva Wollenberg, Robert Zougmoré
Beyond Climate-Smart Agriculture: Toward Safe Operating Spaces For Global Food Systems, Henry Neufeldt, Molly Jahn, Bruce M. Campbell, John R. Beddington, Fabrice Declerck, Alessandro De Pinto, Jay Gulledge, Jonathan Hellin, Mario Herrero, Andy Jarvis, David Lezaks, Holger Meinke, Todd Rosenstock, Mary Scholes, Robert Scholes, Sonja Vermeulen, Eva Wollenberg, Robert Zougmoré
Rubenstein School of Environment and Natural Resources Faculty Publications
Agriculture is considered to be "climate-smart" when it contributes to increasing food security, adaptation and mitigation in a sustainable way. This new concept now dominates current discussions in agricultural development because of its capacity to unite the agendas of the agriculture, development and climate change communities under one brand. In this opinion piece authored by scientists from a variety of international agricultural and climate research communities, we argue that the concept needs to be evaluated critically because the relationship between the three dimensions is poorly understood, such that practically any improved agricultural practice can be considered climate-smart. This lack of …
The Genome And Developmental Transcriptome Of The Strongylid Nematode Haemonchus Contortus, Erich M. Schwarz, Pasi K. Korhonen, Bronwyn E. Campbell, Neil D. Young, Aaron R. Jex, Abdul Jabbar, Ross S. Hall, Alinda Mondal, Adina C. Howe, Jason Pell, Andreas Hofmann, Peter R. Boag, Xing-Quan Zhu, T. Ryan Gregory, Alex Loukas, Brian A. Williams, Igor Antoshechkin, C. Titus Brown, Paul W. Sternberg, Robin B. Gasser
The Genome And Developmental Transcriptome Of The Strongylid Nematode Haemonchus Contortus, Erich M. Schwarz, Pasi K. Korhonen, Bronwyn E. Campbell, Neil D. Young, Aaron R. Jex, Abdul Jabbar, Ross S. Hall, Alinda Mondal, Adina C. Howe, Jason Pell, Andreas Hofmann, Peter R. Boag, Xing-Quan Zhu, T. Ryan Gregory, Alex Loukas, Brian A. Williams, Igor Antoshechkin, C. Titus Brown, Paul W. Sternberg, Robin B. Gasser
Adina Howe
Background The barber's pole worm, Haemonchus contortus, is one of the most economically important parasites of small ruminants worldwide. Although this parasite can be controlled using anthelmintic drugs, resistance against most drugs in common use has become a widespread problem. We provide a draft of the genome and the transcriptomes of all key developmental stages of H. contortus to support biological and biotechnological research areas of this and related parasites. Results The draft genome of H. contortus is 320 Mb in size and encodes 23,610 protein-coding genes. On a fundamental level, we elucidate transcriptional alterations taking place throughout the life …
Near-Unity Nuclear Polarization With An Open-Source 129xe Hyperpolarizer For Nmr And Mri, Panayiotis Nikolaou, Aaron M. Coffey, Laura L. Walkup, Brogan M. Gust, Nicholas Whiting, Hayley Newton, Scott Barcus, Iga Muradyan, Mikayel Dabaghyan, Gregory D. Moroz, Matthew S. Rosen, Samuel Patz, Michael J. Barlow, Eduard Y. Chekmenev, Boyd M. Goodson
Near-Unity Nuclear Polarization With An Open-Source 129xe Hyperpolarizer For Nmr And Mri, Panayiotis Nikolaou, Aaron M. Coffey, Laura L. Walkup, Brogan M. Gust, Nicholas Whiting, Hayley Newton, Scott Barcus, Iga Muradyan, Mikayel Dabaghyan, Gregory D. Moroz, Matthew S. Rosen, Samuel Patz, Michael J. Barlow, Eduard Y. Chekmenev, Boyd M. Goodson
Nicholas Whiting
Writing For Publication In Biomedical Informatics Journals, Christoph Lehmann, Reinhold Haux, Jan Talmon, Dominik Aronsky, Nicolette De Keizer, Tze-Yun Leong, Charles Safran
Writing For Publication In Biomedical Informatics Journals, Christoph Lehmann, Reinhold Haux, Jan Talmon, Dominik Aronsky, Nicolette De Keizer, Tze-Yun Leong, Charles Safran
Research Collection School Of Computing and Information Systems
No abstract provided.
The Impact Of Lateral Electron Disequilibrium On Stereotactic Body Radiation Therapy Of Lung Cancer, Brandon Disher
The Impact Of Lateral Electron Disequilibrium On Stereotactic Body Radiation Therapy Of Lung Cancer, Brandon Disher
Electronic Thesis and Dissertation Repository
Stereotactic Body Radiation Therapy (SBRT) is an effective treatment option for patients with inoperable early-stage lung cancer. SBRT uses online image-guidance technology [e.g. cone-beam CT (CBCT)] to focus small-fields of high energy x-rays onto a tumour to deliver ablative levels of radiation dose (e.g. 54 Gy) in a few treatment fractions (e.g. 3). For the combination of these treatment parameters and a low density lung, lateral electron disequilibrium (LED) can potentially occur, reducing lung and tumour doses. The goal of this thesis was to determine the impact of LED on stereotactic body radiation therapy for lung cancer.
The effect of …
Word Recognition From Continuous Articulatory Movement Time-Series Data Using Symbolic Representations, Jun Wang, Arvind Balasubramanian, Luis Mojica De La Vega, Jordan R. Green, Ashok Samal, Balakrishnan Prabhakaran
Word Recognition From Continuous Articulatory Movement Time-Series Data Using Symbolic Representations, Jun Wang, Arvind Balasubramanian, Luis Mojica De La Vega, Jordan R. Green, Ashok Samal, Balakrishnan Prabhakaran
CSE Conference and Workshop Papers
Although still in experimental stage, articulation-based silent speech interfaces may have significant potential for facilitating oral communication in persons with voice and speech problems. An articulation-based silent speech interface converts articulatory movement information to audible words. The complexity of speech production mechanism (e.g., co-articulation) makes the conversion a formidable problem. In this paper, we reported a novel, real-time algorithm for recognizing words from continuous articulatory movements. This approach differed from prior work in that (1) it focused on word-level, rather than phoneme-level; (2) online segmentation and recognition were conducted at the same time; and (3) a symbolic representation (SAX) was …
A Supramolecular Strategy To Assemble Multifunctional Viral Nanoparticles, Limin Chen, Xia Zhao, Yuan Lin, Yubin Huang, Qian Wang
A Supramolecular Strategy To Assemble Multifunctional Viral Nanoparticles, Limin Chen, Xia Zhao, Yuan Lin, Yubin Huang, Qian Wang
Faculty Publications
Using a one-pot approach driven by the supramolecular interaction between β-cyclodextrin and adamantyl moieties, multifunctional viral nanoparticles can be facilely formulated for biomedical applications.