Physical Sciences and Mathematics Commons^™

Chlomid, Niki Smith

Natural Sciences Student Research Presentations

This poster details the use of Clomid and provides a chemical analysis.

Testosterone Use And Effects, Brandon Mills

Natural Sciences Student Research Presentations

Summarizes the chemical make-up, medical applications and side effects for the steroidal hormone Testosterone. This is a project for the Natural Sciences Poster Session at Parkland College.

Lyrica, Shannon Hayward

Natural Sciences Student Research Presentations

Illustrates the chemical components of Lyrica, a pain management medication.

Modeling The Impact And Costs Of Semiannual Mass Drug Administration For Accelerated Elimination Of Lymphatic Filariasis, Wilma A. Stolk, Quirine A. Ten Bosch, Sake J. De Vlas, Peter U. Fischer, Gary J. Weil, Ann S. Goldman

Epidemiology Faculty Publications

The Global Program to Eliminate Lymphatic Filariasis (LF) has a target date of 2020. This program is progressing well in many countries. However, progress has been slow in some countries, and others have not yet started their mass drug administration (MDA) programs. Acceleration is needed. We studied how increasing MDA frequency from once to twice per year would affect program duration and costs by using computer simulation modeling and cost projections. We used the LYMFASIM simulation model to estimate how many annual or semiannual MDA rounds would be required to eliminate LF for Indian and West African scenarios with varied …

A Case–Control Study Of Incident Rheumatological Conditions Following Acute Gastroenteritis During Military Deployment, Kathryn Deyoung, Mark A. Riddle, Larissa S. May, Chad K. Porter

Epidemiology Faculty Publications

Objectives The aim of this study was to assess the risk of incident rheumatological diagnoses (RD) associated with self-reported diarrhoea and vomiting during a first-time deployment to Iraq or Afghanistan. Such an association would provide evidence that RD in this population may include individuals with reactive arthritis (ReA) from deployment-related infectious gastroenteritis.

Design This case–control epidemiological study used univariate and multivariate logistic regression to compare the odds of self-reported diarrhoea/vomiting among deployed US military personnel with incident RD to the odds of diarrhoea/vomiting among a control population.

Setting We analysed health records of personnel deployed to Iraq or Afghanistan, including …

Environmental Exposure To Pyrethroids And Sperm Sex Chromosome Disomy: A Cross-Sectional Study, Heather A. Young, John D. Meeker, Sheena E. Martenies, Zaida I. Figueroa, Dana Boyd Barr, Melissa J. Perry

Epidemiology Faculty Publications

Background

The role of environmental pesticide exposures, such as pyrethroids, and their relationship to sperm abnormalities are not well understood. This study investigated whether environmental exposure to pyrethroids was associated with altered frequency of sperm sex chromosome disomy in adult men.

Methods

A sample of 75 subjects recruited through a Massachusetts infertility clinic provided urine and semen samples. Individual exposures were measured as urinary concentrations of three pyrethroid metabolites ((3-phenoxybenzoic acid (3PBA), cis- and trans- 3-(2,2-Dichlorovinyl)-1-methylcyclopropane-1,2-dicarboxylic acid (CDCCA and TDCCA)). Multiprobe fluorescence in situ hybridization for chromosomes X, Y, and 18 was used to determine XX, YY, XY, 1818, and …

Food For Thought … Mechanistic Validation, Thomas Hartung, Sebastian Hoffman, Martin Stephens

Experimentation Collection

Validation of new approaches in regulatory toxicology is commonly defined as the independent assessment of the reproducibility and relevance (the scientific basis and predictive capacity) of a test for a particular purpose. In large ring trials, the emphasis to date has been mainly on reproducibility and predictive capacity (comparison to the traditional test) with less attention given to the scientific or mechanistic basis. Assessing predictive capacity is difficult for novel approaches (which are based on mechanism), such as pathways of toxicity or the complex networks within the organism (systems toxicology). This is highly relevant for implementing Toxicology for the 21st …

Development Of Affinity Microcolumns For Drug–Protein Binding Studies In Personalized Medicine: Interactions Of Sulfonylurea Drugs With In Vivo Glycated Human Serum Albumin, Jeanethe Anguizola, K. S. Joseph, Omar S. Barnaby, Ryan Matsuda, Guadalupe Alvarado, William Clarke, Ronald Cerny, David S. Hage

David Hage Publications

This report used high-performance affinity microcolumns to examine the changes in binding by sulfonylurea drugs to in vivo glycated HSA that had been isolated from individual patients with diabetes. An immunoextraction approach was developed to isolate HSA and glycated HSA from clinical samples, using only 20 μL of plasma or serum and 6–12 nmol of protein to prepare each affinity microcolumn. It was found that the affinity microcolumns could be used in either frontal analysis or zonal elution studies, which typically required only 4–8 min per run. The microcolumns had good stability and allowed data to be obtained for multiple …

Striatal Dopamine Dynamics Upon Manganese Accumulation, Madiha Khalid

Wayne State University Dissertations

STRIATAL DOPAMINE DYNAMICS UPON MANGANESE ACCUMULATION

by MADIHA KHALID

August 2013

Advisor: Dr. Tiffany Mathews

Major: Chemistry (Analytical)

Degree: Doctor of Philosophy

Although manganese (Mn) is fundamental for many biological processes, exposure to excess amounts leads to a neurological disorder termed manganism. Due to its symptomatic similarity to Parkinson's disease, as well its preferential accumulation in dopamine rich brain regions, alterations in the dopamine system are implicated in the onset of manganism. In my research, Mn overexposure is mimicked via subcutaneous administration of manganese chloride to C57BL/6 mice over the course of seven days using a protocol that has been …

Interactions Between Serotypes Of Dengue Highlight Epidemiological Impact Of Cross-Immunity, Nicholas Reich, Sourya Shrestha, Aaron King, Pejman Rohani, Justin Lessler, Siripen Kalayanarooj, In-Kyu Yoon, Robert Gibbons, Donald Burke, Derek Cummings

Nicholas G Reich

Dengue, a mosquito-borne virus of humans, infects over 50 million people annually. Infection with any of the four dengue serotypes induces protective immunity to that serotype, but does not confer long-term protection against infection by other serotypes. The immunological interactions between sero- types are of central importance in understanding epidemiological dynamics and anticipating the impact of dengue vaccines. We analysed a 38-year time series with 12 197 serotyped dengue infections from a hospital in Bangkok, Thailand. Using novel mechanistic models to represent different hypothesized immune interactions between serotypes, we found strong evidence that infec- tion with dengue provides substantial short-term …

Adaptive Randomization To Improve Utility-Based Dose-Finding With Bivariate Ordinal Outcomes., Peter F. Thall

Peter F. Thall

No abstract provided.

Using Joint Utilities Of The Times To Response And Toxicity To Adaptively Optimize Schedule-Dose Regimes, Peter F. Thall

Peter F. Thall

No abstract provided.

Binomial Theorem, Adeshina I. Adekunle Mr

Adeshina I. Adekunle MR

No abstract provided.

Sberia: Set Based Gene Environment Interaction Test For Rare And Common Variants In Complex Diseases, Shuo Jiao, Li Hsu, Stéphane Bézieau, Hermann Brenner, Andrew T. Chan, Jenny Chang-Claude, Loic Le Marchand, Mathieu Lemire, Polly A. Newcomb, Martha L. Slattery, Ulrike Peters

Shuo Jiao

Identification of gene-environment interaction (GxE) is important in understanding the etiology of complex diseases. However, partially due to the lack of power, there have been very few replicated GxE findings compared to the success in marginal association studies. The existing GxE testing methods mainly focus on improving the power for individual markers. In this paper, we took a different strategy and proposed a Set Based gene EnviRonment InterAction test (SBERIA), which can improve the power by reducing the multiple testing burdens and aggregating signals within a set. The major challenge of the signal aggregation within a set is how to …

Mixtures Of Receiver Operating Characteristic Curves, Mithat Gonen

Mithat Gönen

Rationale and Objectives: ROC curves are ubiquitous in the analysis of imaging metrics as markers of both diagnosis and prognosis. While empirical estimation of ROC curves remains the most popular method, there are several reasons to consider smooth estimates based on a parametric model.

Materials and Methods: A mixture model is considered for modeling the distribution of the marker in the diseased population motivated by the biological observation that here is more heterogeneity in the diseased population than there is in the normal one. It is shown that this model results in an analytically tractable ROC curve which is itself …

Software For 'The Predictive Hazard Ratio For Biomarker Evaluation Studies', Debashis Ghosh

Debashis Ghosh

This is software to accompany the paper `The predictive hazard ratio for biomarker evaluation studies.' It is saved as a compressed ZIP folder.

The Predictive Hazard Ratio For Biomarker Evaluation Studies, Debashis Ghosh

Debashis Ghosh

There is tremendous scientific and medical interest in the use of biomarkers to better facilitate medical decision making. In this article, we present a simple framework for assessing the predictive ability of a biomarker. The methodology requires use of techniques from a subfield of survival analysis termed semicompeting risks; results are presented to make the article self-contained. A crucial parameter for evaluating is the predictive hazard ratio, which is different from the usual hazard ratio from Cox regression models for right-censored data. This quantity will be defined; its estimation, inference and adjustment for covariates will be discussed. Aspects of censoring …

Mobile Elderly Living Community (Melco): The Development Of The Social Community Model: A Case Study, Christiana Kouta, Charis P. Kaite, George Samaras

Charis P. Kaite

Background: Elderly prefer to be in their own homes rather than being in hospital or residential homes. Communication between elderly and community nurses is essential in caring and mutual interaction and modern technologies like MELCO provides the elderly the feeling of independence and safety. Aim: The aim of this paper is to describe the development of the social community model within the objectives of the MELCO project and its application within the community. Methodology: Three axes were taken in consideration: a) ontology, b) ecological theory and c) social network and information systems analyses for the development of the social community …

Structural Basis For Enzyme I Inhibition By Α-Ketoglutarate, Vincenzo Venditti, Rodolfo Ghirlando, G. Marius Clore

Vincenzo Venditti

Creating new bacterial strains in which carbon and nitrogen metabolism are uncoupled is potentially very useful for optimizing yields of microbial produced chemicals from renewable carbon sources. However, the mechanisms that balance carbon and nitrogen consumption in bacteria are poorly understood. Recently, α-ketoglutarate (αKG), the carbon substrate for ammonia assimilation, has been observed to inhibit Escherichia coli enzyme I (EI), the first component of the bacterial phosphotransferase system (PTS), thereby providing a direct biochemical link between central carbon and nitrogen metabolism. Here we investigate the EI-αKG interaction by NMR and enzymatic assays. We show that αKG binds with a KD …

Structure, Dynamics And Biophysics Of The Cytoplasmic Protein–Protein Complexes Of The Bacterial Phosphoenolpyruvate: Sugar Phosphotransferase System, Vincenzo Venditti

Vincenzo Venditti

The bacterial phosphotransferase system (PTS) couples phosphoryl transfer, via a series of bimolecular protein–protein interactions, to sugar transport across the membrane. The multitude of complexes in the PTS provides a paradigm for studying protein interactions, and for understanding how the same binding surface can specifically recognize a diverse array of targets. Fifteen years of work aimed at solving the solution structures of all soluble protein–protein complexes of the PTS has served as a test bed for developing NMR and integrated hybrid approaches to study larger complexes in solution and to probe transient, spectroscopically invisible states, including encounter complexes. We review …

New Generation Of Ensemble-Decision Aliquot Ranking Based On Simplified Microfluidic Components For Large-Capacity Trapping Of Circulating Tumor Cells, Mengxia Zhao, Wyatt C. Nelson, Bingchuan Wei, Perry G. Schiro, Bejan M. Hakimi, Eleanor S. Johnson, Robbyn K. Anand, Grace S. Gyurkey, Lisa M. White, Samuel H. Whiting, Andrew L. Coveler, Daniel T. Chiu

Robbyn Anand

Ensemble-decision aliquot ranking (eDAR) is a sensitive and high-throughput method to analyze circulating tumor cells (CTCs) from peripheral blood. Here, we report the next generation of eDAR, where we designed and optimized a new hydrodynamic switching scheme for the active sorting step in eDAR, which provided fast cell sorting with an improved reproducibility and stability. The microfluidic chip was also simplified by incorporating a functional area for subsequent purification using microslits fabricated by standard lithography method. Using the reported second generation of eDAR, we were able to analyze 1 mL of whole-blood samples in 12.5 min, with a 95% recovery …

Predictors Of Treatments Acceptable To Patients For Late-Life Depression, Gerald J. Jogerst, Shimin Zheng, Erik Vanderlip

ETSU Faculty Works

Objectives. Describe older patients’ perceptions about depression and characteristics associated with acceptance of treatments. Design. Cross-sectional study. Setting. Three primary care clinics in Iowa. Participants. Consecutive sample of 529 primary care patients. Measurements. Depression screening tool (a 9-item patient health questionnaire [PHQ-9]) and questionnaire including sociodemographic data, patient attitudes about depression, and acceptability of different treatments. Results. Mean age was 71.9 years (range 60–93 years), 314 (59%) female. Among the 529 participants, 93 (17.5%) had history of depression and 60 (11.3%) had PHQ-9 scores of 10 or greater. Participants believed depression is a disease for which they would use medication …

Transmission Rate In Partial Differential Equation In Epidemic Models, Alaa Elkadry

Theses, Dissertations and Capstones

The rate at which susceptible individuals become infected is called the transmission rate. It is important to know this rate in order to study the spread and the effect of an infectious disease in a population. This study aims at providing an understanding of estimating the transmission rate from mathematical models representing the population dynamics of an infectious diseases using two different methods. Throughout, it is assumed that the number of infected individuals is known. In the first chapter, it includes historical background for infectious diseases and epidemic models and some terminology needed to understand the problems. Specifically, the partial …

Santa Clara Magazine, Volume 54 Number 4, Spring/Summer 2013, Santa Clara University

Santa Clara Magazine

12 - KEEP THE DOOR OPEN By Jeff Zorn. For teaching and advising and a ministry that's blessed this place for 48 years-a colleague pays tribute to Charles Phipps, S.J.

16 - IN THIS TOGETHER By Mitch FINLEY '73. For folks retired but not at rest, Companions in Ignatian Service and Spirituality offers a way to do and be more.

18 - WALK ACROSS CALIFORNIA By Jesse Hamlin-with images by Robert Boscacci '14, Frederic Larson, and Edward Rooks. An epic journey in which one foot is put in front of the other to discover, up close and personal, who and …

Preparation Of Phosphonoterephthalic Acids Via Palladium-Catalyzed Coupling Of Aromatic Iodoesters, Nathaniel Ivan, Vladimir Benin, Alexander Morgan

Chemistry Faculty Publications

The current article reports in detail the preparation of two phosphonoterephthalic acids: 2-phosphonoterephthalic acid (1) and 2,5-diphosphonoterephthalic acid (2). Efficient, scalable syntheses have been developed for both compounds based on Pd-catalyzed coupling reactions of iodinated terephthalate esters. Phosphonoterephthalic acids are potentially useful as flame-retardant additives or as monomers for the construction of acid-pendant polymer chains.

Reaction Between Polyol-Esters And Phosphate Esters In The Presence Of Metal Carbides, David W. Johnson, Carolyn Iacullo, John E. Hils

Chemistry Faculty Publications

The reaction of metal carbides with polyol esters found in aerospace lubricants and phosphate esters commonly used as additives was investigated. Carbides were of particular interest since modern materials under consideration at high temperature bearings have surfaces that are primarily metal carbides. Vanadium and chromium carbide were found to react with the ester and phosphate ester by a transesterification reaction, producing an alkyl phosphate which is less stable than the aromatic phosphate esters. In the process, the metal carbide is converted to the metal phosphate and metal polyphosphate, evidenced by the infrared and Raman spectra of the solid residue and …

Post Use Analysis Of Firefighter Turnout Gear- Phase Iii, Meredith Laine Cinnamon

Theses and Dissertations--Retailing and Tourism Management

The purpose of this research was to perform a post-use evaluation of retired firefighter turnout gear. Garments were categorized as 10-12 years old, 13-17 years old and 18-21 years old. Inspection and test procedures required by National Fire Protection Association (NFPA) 1851 and NFPA 1971 were followed to determine if the current recommended 10 year wear life (retirement age) is appropriate. Testing included a visual inspection (closure system functionality, light evaluation, leakage evaluation and flashlight test) and performance properties (Thermal Protective Performance (TPP), flammability, breaking strength, tear strength, seam strength and water penetration) completed on 108 garments. Ten-year retirement, care, …

Santa Clara Magazine, Volume 55 Number 1, Fall 2013, Santa Clara University

Santa Clara Magazine

6 - ONE IN A MILLION By Michael E. Engh, S.J. A note of thanks from the president to SCU alumni. For the Leavey Challenge, you came through in record numbers to secure a $1 million challenge grant for the University.

20 - GOOD LIGHT: A PHOTO RETROSPECTIVE with Charles Barry. For a quarter century he has told Santa Clara's stories in photographs. Here are a few.

26 - YES, BUT IS IT THE RIGHT THING TO DO? By Sam Scott '96. From business to government to college campuses, it's not always a question that gets asked. But here's how …

The Palm-Tree Index: Indexing With The Crowd, Aamer Mahmood, Walid G. Aref, Eduard Dragut, Saleh Basalamah

Cyber Center Publications

Crowdsourcing services allow employing human intelligence in tasks that are difficult to accomplish with computers such as image tagging and data collection. At a relatively low monetary cost and through web interfaces such as Amazon’s Mechanical Turk (AMT), humans can act as a computational operator in large systems. Recent work has been conducted to build database management systems that can harness the crowd power in database operators, such as sort, join, count, etc. The fundamental problem of indexing within crowdsourced databases has not been studied. In this paper, we study the problem of tree-based indexing within crowd-nabled databases. We investigate …

Sanitation Infrastructure, Medicinal Plant Use And Diarrhea In Rural Costa Rican Communities, Travis Clifford Sondgerath

Open Access Theses

Diarrhea is estimated to be responsible for 3.3 million deaths a year and is particularly problematic in the developing world among children. The Millennium Development Goals established by the United Nations has set a goal of reducing mortality among children by two thirds during the new millennium. However due to the nature of diarrhea it is often difficult to study its patterns, distribution, and determinants.

This study presents an analysis of the relationship between diarrhea and sanitation infrastructure and medicinal plant use in 4 rural Costa Rican communities. Over the past few decades' access to clean drinking water and municipal …