Physical Sciences and Mathematics Commons^™

Crystal Structures Of Human Ctbp In Complex With Substrate Mtob Reveal Active Site Features Useful For Inhibitor Design, Brendan Hilbert, Steven Grossman, Celia Schiffer, William Royer

Celia A. Schiffer

The oncogenic corepressors C-terminal Binding Protein (CtBP) 1 and 2 harbor regulatory d-isomer specific 2-hydroxyacid dehydrogenase (d2-HDH) domains. 4-Methylthio 2-oxobutyric acid (MTOB) exhibits substrate inhibition and can interfere with CtBP oncogenic activity in cell culture and mice. Crystal structures of human CtBP1 and CtBP2 in complex with MTOB and NAD(+) revealed two key features: a conserved tryptophan that likely contributes to substrate specificity and a hydrophilic cavity that links MTOB with an NAD(+) phosphate. Neither feature is present in other d2-HDH enzymes. These structures thus offer key opportunities for the development of highly selective anti-neoplastic CtBP inhibitors. Elsevier B.V. All …

Drug Resistance Mutations Alter Dynamics Of Inhibitor-Bound Hiv-1 Protease, Yufeng Cai, Wazo Myint, Janet Paulsen, Celia Schiffer, Rieko Ishima, Nese Yilmaz

Celia A. Schiffer

Under the selective pressure of therapy, HIV-1 protease mutants resistant to inhibitors evolve to confer drug resistance. Such mutations can impact both the dynamics and structures of the bound and unbound forms of the enzyme. Flap+ is a multidrug-resistant variant of HIV-1 protease with a combination of primary and secondary resistance mutations (L10I, G48V, I54V, V82A) and a strikingly altered thermodynamic profile for darunavir (DRV) binding relative to the wild-type protease. We elucidated the impact of these mutations on protein dynamics in the DRV-bound state using molecular dynamics simulations and NMR relaxation experiments. Both methods concur in that the conformational …

Exposing Potential Privacy Issues With Ipv6 Address Construction, Clinton Carpene, Andrew Woodward

Clinton Carpene

The usage of 128 bit addresses with hexadecimal representation in IPv6 poses significant potential privacy issues. This paper discusses the means of allocating IPv6 addresses, along with the implications each method may have upon privacy in different usage scenarios. The division of address space amongst the global registries in a hierarchal fashion can provide geographical information about the location of an address, and its originating device. Many IPv6 address configuration methods are available, including DHCPv6, SLAAC (with or without privacy extensions), and Manual assignment. These assignment techniques are dissected to expose the identifying characteristics of each technique. It is seen …

Looking To Iphone Backup Files For Evidence Extraction, Clinton Carpene

Clinton Carpene

iPhone logical backup files can provide forensic examiners with almost the entire contents of its host phone up until the point that the backup took place. This paper serves to provide an overview of the information attainable via the analysis of an iPhone backup, making references to the applicability of such analysis in the digital forensics field. The paper introduces the backup directories for various common operating systems, and exposes the contents. Information about the property lists (plist files) containing information about the backed-up device and its contents are detailed, along with the mbdb/mbdx database files, and finally the extension-less …

Improved Photoluminescence Of Vertically Aligned Zno Nanorods Grown On Basrtio3 By Pulsed Laser Deposition, C. Varanasi, Kevin Leedy, David Tomich, Guru Subramanyam, David Look

Guru Subramanyam

ZnO nanorods were grown on a variety of substrates such as Si, SiO2/Si and sapphire in a large-area pulsed laser deposition chamber designed for sensor device fabrication. Processing conditions were optimized to grow ZnO nanorods with or without seed layers. Au, Cr and BaSrTiO3 (BST) seed layers were investigated to compare their effects on the diameter and orientation of ZnO nanorods. ZnO nanorods were observed to align better when grown on sapphire, Cr or BST seed layers as compared to Au or Si layers. The highest quality nanorods were those grown on BST seed layers, as shown by 4 K …

The Lyman Alpha Reference Sample: Iv. Morphology At Low And High Redshift, L. Guaita, J. Melinder, M. Hayes, G. Ostlin, J. Gonzalez, A. Adamo, J. Mas-Hesse, A. Sandberg, H. Oti-Floranes, D. Schaerer, A. Verhamme, E. Freeland, I. Orlitova, P. Laursen, John Cannon, F. Duval, T. Rivera-Thorsen, E. Herenz, D. Kunth, H. Atek, J. Puschnig, P. Gruyters, S. Pardy

John Cannon

No abstract provided.

Voting Rules As Error Correcting Codes, Nisarg Shah, Ariel Procaccia, Yair Zick

Yair Zick

No abstract provided.

Field Validation Of Dem And Gis Derived Longitudinal Stream Profiles, Kathryn Schroeder, Eric Peterson, Toby Dogwiler

Eric Wade Peterson

Longitudinal stream profiles provide valuable information concerning geomorphic features and energy states in a stream. Traditionally, stream profiles have been generated by field surveying or topographic map analysis. The continued growth of digital data and Geographic Information Systems (GISs) provide another method by which to achieve stream profile generation. This work examines the effectiveness of digital data, digital elevation models (DEM), and GIS to construct stream profiles. To determine the most effective and accurate data for profile generation, profiles were created using 1-meter (1-m) and 3-meter (3-m) DEMs developed from LiDAR data. Additionally, stream profiles were created from unfilled DEMs …

Oxygen Abundance Measurements Of Shield Galaxies, N. Haurberg, J. Salzer, John Cannon, M. Marshall

John Cannon

No abstract provided.

Agc198606: A Gas-Bearing Dark Matter Minihalo?, E. Adams, Y. Faerman, W. Janesh, S. Janowiecki, T. Oosterloo, K. Rhode, R. Giovanelli, M. Haynes, J. Salzer, A. Sternberg, John Cannon, R. Munoz

John Cannon

No abstract provided.

The Alfalfa "Almost Darks" Campaign: Pilot Vla Hi Observations Of Five High Mass-To-Light Ratio Systems, John Cannon, C. Martinkus, L. Leisman, M. Haynes, E. Adams, R. Giovanelli, G. Hallenbeck, S. Janowiecki, M. Jones, G. Josza, R. Koopmann, N. Nichols, E. Papastergis, K. Rhode, J. Salzer, P. Trosicht

John Cannon

No abstract provided.

(Almost) Dark Hi Sources In The Alfalfa Survey: The Intriguing Case Of Hi1232+20, Steven Janowiecki, Lukas Leisman, Gyula Jozsa, John Salzer, Martha Haynes, Riccardo Giovanelli, Katherine Rhode, John Cannon, Elizabeth Adams, William Janesh

John Cannon

No abstract provided.

Computer Science, Ying Chen

Ying Chen

This research guide includes lists and links for recommended databases, journals, and web resources on computer science. It also provides helpful information for citation and writing with emphasis on the science disciplines.

Optimal Restricted Estimation For More Efficient Longitudinal Causal Inference, Edward Kennedy, Marshall Joffe, Dylan Small

Edward H. Kennedy

Efficient semiparametric estimation of longitudinal causal effects is often analytically or computationally intractable. We propose a novel restricted estimation approach for increasing efficiency, which can be used with other techniques, is straightforward to implement, and requires no additional modeling assumptions.

Computational Estimation Of Pka Values, Paul Seybold, George Shields

Berhane Temelso

The pKa of a compound is one of its most important properties as it defines the specific molecular forms that will prevail under different pH conditions. Accordingly, accurate means for computational estimation of this property are of particular interest. Two main techniques for this purpose have emerged: (1) a first principles approach that relies on basic physical concepts and requires high computational resources, but is independent of experimental input and (2) a linear free energy or quantitative structure–activity relationship (QSAR) approach that combines molecular structural and energetic descriptors with available experimental pKa data to reduce computational demand and yield good …

Non-Myopic Negotiators See What's Best, Yair Zick, Yoram Bachrach, Ian Kash, Peter Key

Yair Zick

No abstract provided.

Information Technology, Ying Chen

Ying Chen

This research guide includes lists and links for recommended databases, journals, and web resources on Information Technology. It also provides helpful information for citation and writing with emphasis on the science disciplines.

Longitudinal Profile And Sediment Mobility As Geomorphic Tools To Interpret The History Of A Fluviokarst Stream System, John Woodside, Eric Peterson, Toby Dogwiler

Eric Wade Peterson

The complex drainage systems within karst settings can result in atypical longitudinal profiles. Features, such as cave entrances, can be expressed as anomalous ‘bumps’ in the longitudinal profile of a stream if downcutting has continued upstream of the area in which the water is pirated to the subsurface. Horn Hollow, a fluviokarst valley located in Carter Caves State Park Resort in northeastern Kentucky, was examined for these types of features. The objectives of this study were to determine if sediment mobility can be used as a proxy for anomalous areas along the profile of the valley and if detailed cross-sections …

The Role Of Histidine Residues In The Specificity Of The Human Zinc Transporter Hzip4, Robert Dempski, Sagar Antala, Elizabeth Bafaro

Robert E. Dempski

ZIP transporters, named after the zinc regulated (Zrt) and iron regulated (Irt) transport proteins, are essential for zinc and iron translocation across cellular membranes. These proteins function to increase the cytosolic concentration of transition metals. While both zinc and iron are essential micronutrients which are required for the structure and/or function of hundreds of cellular proteins, the molecular mechanism of ZIP transporters is not well understood. Complicating mechanistic studies is the observation that the concentration of free zinc and iron is nano to picomolar.

The Lyman Alpha Reference Sample: V. Empirical Inferences On The Lyman Alpha Output From High-Resolution Ultraviolet Spectroscopy, T. Rivera-Thorsen, M. Hayes, G. Ostlin, F. Duval, I. Orlitova, A. Verhamme, J. Mas-Hesse, D. Schaerer, John Cannon, H. Oti-Floranes, A. Sandberg, L. Guaita, A. Adamo, H. Atek, E. Herenz, D. Kunth, P. Laursen, J. Melinder

John Cannon

No abstract provided.

Implantable Polymer/Metal Thin Film Structures For The Localized Treatment Of Cancer By Joule Heating, Nima Rahbar, Kwabena Kan-Dapaah, Christian Theriault, Wole Soboyejo

Nima Rahbar

This paper presents an implantable polymer/metal alloy thin film structure for localized post-operative treatment of breast cancer. A combination of experiments and models is used to study the temperature changes due to Joule heating by patterned metallic thin films embedded in poly-dimethylsiloxane. The heat conduction within the device and the surrounding normal/cancerous breast tissue is modeled with three-dimensional finite element method (FEM). The FEM simulations are used to explore the potential effects of device geometry and Joule heating on the temperature distribution and lesion (thermal dose). The FEM model is validated using a gel model that mimics biological media. The …

Wavelet Analysis And Applications In Economics And Finance, Tian-Xiao He, Tung Nguyen, '15

Tian-Xiao He

Rotation Period Of 584 Semiramis, Linda French, Kyle Connour, Tyler Wright

Linda French

Stratigraphy And Porosity Modeling Of Southern Centeral Illinois Chester (Upper Missisippian) Series Sandstones Usng Petrel, Darren Kimple, Eric Peterson, David Malone

Eric Wade Peterson

Probabilistic Analysis Of The Economic Impact Of Earthquake Prediction Systems, Tiffany Kolba, Ruyue Yuan

Tiffany N Kolba

Identification Of Potential Vertical Gas Migration Pathways Above Gas Storage Reservoirs, Eric Peterson, Lauren Martin, David Malone

Eric Wade Peterson

Predicting Financial Distress: A Comparison Of Survival Analysis And Decision Tree Techniques, Adrian Gepp, Kuldeep Kumar

Adrian Gepp

Financial distress and then the consequent failure of a business is usually an extremely costly and disruptive event. Statistical financial distress prediction models attempt to predict whether a business will experience financial distress in the future. Discriminant analysis and logistic regression have been the most popular approaches, but there is also a large number of alternative cutting – edge data mining techniques that can be used. In this paper, a semi-parametric Cox survival analysis model and non-parametric CART decision trees have been applied to financial distress prediction and compared with each other as well as the most popular approaches. This …

Characterizing The Star Formation Of The Low-Mass Shield Galaxies From Hubble Space Telescope Imaging, K. Mcquinn, John Cannon, A. Dolphin, E. Skillman, M. Haynes, J. Simones, J. Salzer, E. Adams, E. Elson, R. Giovanelli, J. Ott

John Cannon

No abstract provided.

Semiparametric Theory And Empirical Processes In Causal Inference, Edward Kennedy

Edward H. Kennedy

In this paper we review important aspects of semiparametric theory and empirical processes that arise in causal inference problems. We begin with a brief introduction to the general problem of causal inference, and go on to discuss estimation and inference for causal effects under semiparametric models, which allow parts of the data-generating process to be unrestricted if they are not of particular interest (i.e., nuisance functions). These models are very useful in causal problems because the outcome process is often complex and difficult to model, and there may only be information available about the treatment process (at best). Semiparametric theory …

Carrier Heating And Negative Photoconductivity In Graphene, James Heyman, J. D. Stein, Z. S. Kaminski, A. R. Banman, A. M. Massari, J. T. Robinson

James Heyman

No abstract provided.