Physical Sciences and Mathematics Commons^™

Fluorescence-Based Ratiometric Nanosensor For Selective Imaging Of Cancer Cells, Isiah M. Warner, Kelsey E. Mcneel, Noureen Siraj, Nimisha Bhattarai

Faculty Publications

Herein, we report the synthesis and characterization of a nanosensor developed from a group of uniform materials based on organic salts (GUMBOS). This sensor is composed of three ionic species, namely, fluorescein, rhodamine B, and tetradecyltrihexyl phosphonium (P-66614) ions. Nanoparticles prepared from this three-component GUMBOS, termed nanoGUMBOS, exhibited increased fluorescence at two wavelengths with increases in pH values. The ratio of fluorescence emission corresponding to FL and RhB components of these nanoGUMBOS also changed with pH, allowing ratiometric analysis of pH through fluorescence measurements. Peak ratios were significantly different at pH 5 and pH 7, indicating potential applications of this …

Synthesis And Investigation Of Phthalocyanine-Biotin Conjugates, M. Graca H. Vicente, Elizabeth A. Okoth, Zehua Zhou, Benson Ongarora

Faculty Publications

An isothiocyanato-functionalized phthalocyanine (Pc) was synthesized in good yield from the corresponding amine-substituted Pc. This Pc reacted with ethanolamine, biotin hydrazine, and biotin diethylamine under mild conditions (room temperature in DMF or DMSO in the presence of TEA) to produce the corresponding thiourea products in 60-75% yields. All Pcs showed intense Q absorptions in DMF around 677 nm, emissions centered at 683 nm, and fluorescence quantum yields in the range 0.18-0.27. The Pcs were phototoxic to human carcinoma HEp2 cells (IC50 similar to 7 at 1.5 J/cm(2)) and localized in multiple organelles, including the lysosomes, Golgi and ER. One biotin-Pc …

Predicting Post-Procedural Complications Using Neural Networks On Mimic-Iii Data, Namratha Mohan

LSU Master's Theses

The primary focus of this paper is the creation of a Machine Learning based algorithm for the analysis of large health based data sets. Our input was extracted from MIMIC-III, a large Health Record database of more than 40,000 patients. The main question was to predict if a patient will have complications during certain specified procedures performed in the hospital. These events are denoted by the icd9 code 996 in the individuals' health record. The output of our predictive model is a binary variable which outputs the value 1 if the patient is diagnosed with the specific complication or 0 …

Singularity Resolution In Anisotropic And Black Hole Spacetimes In Loop Quantum Cosmology, Sahil Saini

LSU Doctoral Dissertations

Loop quantum cosmology (LQC) has in recent years led to successful resolution of singularities in cosmological models while agreeing with general relativity in low curvature limit. Existence of a bounce and the possibility of an effective continuum description closely approximating the quantum evolution have been notable features of this singularity resolution. The effective spacetimes of loop quantized isotropic and Bianchi-I models have been shown to be geodesically complete and free from strong singularities. In this dissertation, we extend these results to effective loop quantized Bianchi-II, Bianchi-IX and Kantowski--Sachs models with arbitrary minimally coupled matter, and also explore the possibility of …

Non-Continuous Double Barrier Reflected Bsdes With Jumps Under A Stochastic Lipschitz Coefficient, Mohamed Marzougue, Mohamed El Otmani

Communications on Stochastic Analysis

No abstract provided.

Functional Central Limit Theorem For Additive Functionals Associated To The Generalized Nelson Hamiltonian, Soumaya Gheryani, Achref Majid, Habib Ouerdiane

Communications on Stochastic Analysis

No abstract provided.

Generalized Random Fields And Lévy's Continuity Theorem On The Space Of Tempered Distributions, Hermine Biermé, Olivier Durieu, Yizao Wang

Communications on Stochastic Analysis

No abstract provided.

Stochastic Differential Equations With Anticipating Initial Conditions, Hui-Hsiung Kuo, Sudip Sinha, Jiayu Zhai

Communications on Stochastic Analysis

No abstract provided.

On A Stochastic 2d Simplified Liquid Crystal Model Driven By Jump Noise, T. Tachim Medjo

Communications on Stochastic Analysis

No abstract provided.

New Filters For The Calibration Of Regime Switching Beta Dynamics, Robert J. Elliott, Carlton Osakwe

Communications on Stochastic Analysis

No abstract provided.

Stochastic Lagrangian Formulations For Damped Navier-Stokes Equations And Boussinesq System, With Applications, Kazuo Yamazaki

Communications on Stochastic Analysis

No abstract provided.

High-Throughput Assessment Of A Novel, Thiol-Acrylate Hydrogel For Tumor Spheroid Synthesis In A Microfluidic Device, Nathan Daniel Kersker

LSU Master's Theses

The extracellular environment plays an important role in regulating cell behavior. The mechanical, structural, and compositional properties of the extracellular matrix can determine the fate of the growing cells. Standard two-dimensional culturing in a flask fails to represent a native cellular environment. To create the native environment suitable for cells, hydrogels were previously studied. One of the most extensively studied synthetic hydrogels was a poly(ethylene glycol diacrylate) (PEGDA) hydrogel. However, the need for UV polymerization may introduce unwanted changes in cell morphology and viability. The hydrogel being proposed was a form of a thiol-acrylate hydrogel that can eliminate this problem …

The Effects Of Pressure And Magnetic Field On Phase Transitions And Related Physical Properties In Solid State Caloric Materials, Ahmad Ikhwan Us Saleheen

LSU Doctoral Dissertations

Solid-state caloric effects, such as the magnetocaloric (MCE) and barocaloric (BCE) effects, may be utilized in future cooling technologies that are more efficient and environment-friendly. Large caloric effects often occur near phase transitions, especially near coupled first-order magnetostructural transitions (MST), and are initiated by external parameters, such as magnetic field or hydrostatic pressure. In this dissertation, the effects of pressure, temperature, and magnetic field on the phase transitions in three material systems are studied in order to elucidate how the respective caloric effects are affected.

In the first study, the realization of a coupled MST in a MnNiSi-based system through …

Disappearance Of Phragmites In Louisiana And Nipponaclerda Biwakoensis, Rachel Tugger

Honors Theses

No abstract provided.

An Evaluation Of Modified Bed Load Sediment Transport Equations For Enhanced Sediment Transport Quantification In Steep Mountain Streams – Case Study Little Fountain Creek, Colorado Springs, Co., James Emerson Smith Iv

LSU Master's Theses

In mountainous regions, extreme floods occur every year, placing societies and infrastructures at risk. Communities rely on local, state, and federal agencies to emplace flood structures, perform flood risk assessments, and simulate catastrophic events. While, our ability to quantify and predict the movement of sediment in streams with low gradients is well developed (Bathurst, 1987), our ability to quantify and predict the movement of sediment along steep mountain streams (SMS) has not been developed to a similar degree (Yager, 2012; Schneider, 2016). To most effectively manage mountainous watersheds and understand the risk associated with flood events, scientists must better understand …

Analysis Of Fluvial Scroll Bar Development With Surface Wave Inversion: False River, Louisiana, Blake Odom

LSU Master's Theses

The development of ridge-and-swale scroll bar topography of meandering river point bars is not well understood. We hypothesize that scroll bars formed during lateral accretion by the landward migration of transverse bars. To explore this, we relate the scroll bar topography to the internal sedimentary structure. We acquire, invert, and interpolate three pseudo-2D shear wave velocity profiles in two regions of the False River point bar, a Mississippi river oxbow lake in Pointe Coupee Parish Louisiana. Prior studies provide electrical conductivity well logs and cores as well as SH seismic reflection images along the same seismic surveys. LiDAR elevation data …

From The River To The Gulf: An Investigation Of Biogeochemical Cycling In Wetland Soils And Coastal Shelf Sediments, Katie Bowes

LSU Master's Theses

Louisiana is home to 40% of the coastal wetlands in the lower 48 states, yet accounts for 80% of the coastal wetland loss in this region. This loss is attributed to decreased sediment supply, levee alteration, sea level rise, channelization, and subsidence. The levee system in Louisiana disconnected coastal wetlands from the main stem of the Mississippi River (MSR), reducing the amount of land-building sediment that reaches coastal wetlands. This disconnection also allows a greater percentage of river discharge, including agricultural contaminants and runoff, to flow into the northern Gulf of Mexico (NGOM).

The 2012 Coastal Master Plan proposed eight …

New Borehole Breakout Derived Stress Constraints And Their Implications For Stress Heterogeneity Near High Risk Fault Systems In The Santa Barbara Channel, Southern California, Edward Harris Pritchard

LSU Master's Theses

The Santa Barbara Channel represents the offshore portion of the Ventura Basin in Southern California. Ongoing transpression related to a regional left step in the San Andreas Fault has led to the formation of E-W trending en-echelon fault systems, with both north and south dips, which accommodate varying rates of localized shortening across the basin. Recent studies have suggested that faults within the northern region of the channel could be capable of a multisegment rupture and producing a M_w 7.7–8.1 tsunamigenic earthquake. However, dynamic rupture models producing these results have not accounted for stress heterogeneity, which is …

Longitudinal Study Of The Attitudes And Behaviors Of Environmental Education Program Participants., Kasie R. Dugas

LSU Master's Theses

The goal of this longitudinal study was to measure the attitudes and behaviors of participants of the Marsh Maneuvers program over the course of the last 25 years. The goal of the Marsh Maneuvers program is to educate students into becoming environmentally literate adults. Environmental literacy is considered herein to be people possessing knowledge about and positive attitudes and behaviors towards the environment. Although students learn basic science and environmental knowledge in the classroom, true environmental literacy is believed to require more hands-on understanding of the material. To evaluate the effectiveness of the program, the following three objectives were completed. …

Calculation Guided Rational Design And Synthesis Of Novel Cationic Fluorescent Meso–Pyridinium Bodipys For Bio-Imaging, Daniel J. Lamaster

LSU Doctoral Dissertations

Chapter 1 contains a brief overview of the history, synthesis, and properties of BODIPY dyes as well as that of the biomedical applications of bio-imaging and photodynamic therapy. Additionally, an overview of the theoretical framework of density functional theory and its time-dependent variant are provided. In Chapter 2, the effects of structural modification on the electronic structure and electron dynamics of cationic meso-(4-pyridyl)-BODIPYs were investigated. A library of 2,6-difunctionalized meso-(4-pyridyl)-BODIPYs bearing various electron-withdrawing substituents was designed and DFT calculations were used to model the redox properties, while TDDFT was used to determine the effects of functionalization on the excited …

Beam Theory For Classical And Quantum Nonlinear Optics---Exposing Classical And Quantum Correlations Of Transverse-Spatial Modes, Robert Nicholas Lanning

LSU Doctoral Dissertations

Optics is arguably the most important branch of physics that has ever been studied. It is not only an essential ingredient of many other branches of physics that we study, it governs how we see, how we measure, and how we communicate in the modern world. And as the world continues to change, so do our tools and resources. In a relatively short amount of time, we have progressed from rudimentary tools that shape the world around us, to tools that harness the fundamental laws of nature. Unsurprisingly, the laws of nature governing optics remain paramount. This is because many …

Effective Visualization Approaches For Ultra-High Dimensional Datasets, Gurminder Kaur

LSU Doctoral Dissertations

Multivariate informational data, which are abstract as well as complex, are becoming increasingly common in many areas such as scientific, medical, social, business, and so on. Displaying and analyzing large amounts of multivariate data with more than three variables of different types is quite challenging. Visualization of such multivariate data suffers from a high degree of clutter when the numbers of dimensions/variables and data observations become too large. We propose multiple approaches to effectively visualize large datasets of ultrahigh number of dimensions by generalizing two standard multivariate visualization methods, namely star plot and parallel coordinates plot. We refine three variants …

Tidal-, Wind-, And Buoyancy-Driven Dynamics In The Barataria Estuary And Its Impact On Estuarine-Shelf Exchange Processes, Linlin Cui

LSU Doctoral Dissertations

A three-dimensional, high-resolution, Finite-Volume Coastal Ocean Model (FVCOM) was used to study the dynamics of Barataria Estuary located in the Southeastern Louisiana. Three numerical experiments with different discharge scenarios, including the actual discharge (average ~ 160 m³ s^-1) from the Davis Pond Diversion (DPD) over three months from April to June 2010, no discharge (NO), and the proposed Mid-Barataria Diversion (MBD) with a constant discharge of 850 m³ s^-1, were conducted to investigate the impacts of river diversions on salinity gradients and residence times in the estuary. The three-month average salinity indicated that surface …

Observation Of High-Energy Gamma-Rays With The Calorimetric Electron Telescope (Calet) On-Board The International Space Station, Nicholas Wade Cannady

LSU Doctoral Dissertations

The CALorimetric Electron Telescope (CALET) is a multi-instrument high-energy astrophysics observatory deployed to the International Space Station (ISS) in August 2015. The primary instrument is the calorimeter (CAL), which is intended for measurement of the cosmic ray electron flux in the energy range 10 GeV - 20 TeV. The CAL is also sensitive to gamma-rays in the energy range 1 GeV - 10 TeV and protons and nuclei up to PeV energies. Also present on the CALET payload are an Advanced Stellar Compass (ASC) for the fine determination of the pointing direction and the CALET Gamma-ray Burst Monitor (CGBM) for …

Influence Of Salinity, Sunlight, And Sediment On The Toxicity Of Pesticides In Three Non-Target Organisms, Emily Noelle Vebrosky

LSU Doctoral Dissertations

Pesticides used in the United States must undergo registration by the United States Environmental Protection Agency (USEPA), after a multitude of analyses ranging from environmental fate to aquatic toxicological impacts to human risk exposure. Testing varies for each chemical, some requiring more testing than others. In many cases, environmental factors are restricted in the analysis of chemical behavior and organismal testing is limited to larvae. Many pesticides are formulated to breakdown in the environment by means of photolysis, hydrolysis, or oxidation, either to ensure low-persistence, limited transport, or to form the active ingredient (pro-pesticides). Environmental influences on chemical behaviors include …

Three-Dimensional Flow, Morphologic Change, And Sediment Deposition And Distribution Of Actively Evolving Neck Cutoffs Located On The White River, Arkansas, Derek Allen Richards

LSU Doctoral Dissertations

Neck cutoffs are important and prominent features of alluvial rivers yet detailed field-based research of neck cutoffs has been insufficient to fully characterize three-dimensional flow, morphologic change, and sediment deposition and distribution. The main objectives of this research are to examine the formation and evolution of neck cutoffs by characterizing the flow field, morphology, and sediment distribution through neck cutoffs with complex planform configurations located on the White River, Arkansas. Results led to the production of two conceptual models. The flow model has main hydrodynamic characteristics of (1) tight bend flow resulting from flow redirection of nearly 180° through the …

A Regional Survey Of River-Plume Sedimentation On The Mississippi River Delta Front, Andrew J. Courtois

LSU Master's Theses

Many studies of the Mississippi River Delta (MRD) have shown historic declines in sediment load over the last few decades. Recent studies also reported that ~50% of the suspended load during floods is sequestered within the delta. While the impact of declining sediment load on wetland loss is relatively well documented, submarine sedimentary processes on the delta front during this recent period of are understudied. To better understand modern sediment dispersal and deposition across the Mississippi River Delta Front, 31 multicores were collected in June 2017 from locations extending offshore from the main river outlets in water depths of 25-280 …

Numerical Study Of Liquid Atomization And Breakup Using The Volume Of Fluid Method In Ansys Fluent, Sai Saran Kandati

LSU Master's Theses

The spherical metal particles produced from the centrifugal atomization process have been the topic of numerous theoretical, experimental and numerical studies from the past few years. This atomization process uses centrifugal force to break-up molten material into spherical droplets, which are quenched into solidified granules by the flow of cold air on the spherical droplets. In the present work, a transient three-dimensional multiphase CFD model is applied to three different materials: Molten slag, aqueous glycerol solution, and molten Ni-Nb to study the influence of the dimensionless parameters on the centrifugal atomization outcome.

Results from numerical experiments indicated that the droplet …

Bipartite Quantum Interactions: Entangling And Information Processing Abilities, Siddhartha Das

LSU Doctoral Dissertations

The aim of this thesis is to advance the theory behind quantum information processing tasks, by deriving fundamental limits on bipartite quantum interactions and dynamics. A bipartite quantum interaction corresponds to an underlying Hamiltonian that governs the physical transformation of a two-body open quantum system. Under such an interaction, the physical transformation of a bipartite quantum system is considered in the presence of a bath, which may be inaccessible to an observer. The goal is to determine entangling abilities of such arbitrary bipartite quantum interactions. Doing so provides fundamental limitations on information processing tasks, including entanglement distillation and secret key …

Theoretical Studies Of Ultrafast Electron Dynamics In Atoms And Molecules Via High-Order Harmonic Generation, Paul Vincent Abanador

LSU Doctoral Dissertations

The interaction of atoms and molecules with strong laser pulses is of fundamental interest in physics and chemistry. Notably, the process known as high-order harmonic generation (HHG) refers to the production of extreme-ultraviolet (XUV) light, which occurs when an ensemble of atoms or molecules is subjected to a strong infrared laser field. Characterized by an attosecond time scale (1 as = 10^-18 s), the HHG process provides the capability for experimental measurements to capture the ultrafast motion of electrons in these target atoms and molecules. The underlying physical mechanism behind this process naturally leaves imprints in the properties of …