Physical Sciences and Mathematics Commons^™

Telotristat Ethyl In Carcinoid Syndrome: Safety And Efficacy In The Telecast Phase 3 Trial, Marianne Pavel, David J. Gross, Marta Benavent, Petros Perros, Raj Srirajaskanthan, Richard R. P. Warner, Matthew H. Kulke, Lowell B. Anthony, Pamela L. Kunz, Dieter Hörsch, Martin O Weickert, Pablo Lapuerta, Wenjun Jiang, Kenneth Kassler-Taub, Suman Wason, Rosanna Fleming, Douglas Fleming, Rocio Garcia-Carbonero

Internal Medicine Faculty Publications

Telotristat ethyl, a tryptophan hydroxylase inhibitor, was efficacious and well tolerated in the phase 3 TELESTAR study in patients with carcinoid syndrome (CS) experiencing ≥ 4 bowel movements per day (BMs/day) while on somatostatin analogs (SSAs). TELECAST, a phase 3 companion study, assessed the safety and efficacy of telotristat ethyl in patients with CS (diarrhea, flushing, abdominal pain, nausea or elevated urinary 5-hydroxyindoleacetic acid (u5-HIAA)) with < 4 BMs/day on SSAs (or ≥ 1 symptom or ≥ 4 BMs/day if not on SSAs) during a 12-week double-blind treatment period followed by a 36-week open-label extension (OLE). The primary safety and efficacy endpoints were incidence of treatment-emergent adverse events (TEAEs) and percent change from baseline in 24-h u5-HIAA at week 12. Patients (N = 76) were randomly assigned (1:1:1) to receive placebo or telotristat ethyl 250 mg or 500 mg 3 times per day (tid); 67 continued receiving telotristat ethyl 500 mg tid during the OLE. …

Kratylos: A Tool For Sharing Interlinearized And Lexical Data In Diverse Formats, Daniel Kaufman, Raphael Finkel

Computer Science Faculty Publications

In this paper we present Kratylos, at www.kratylos.org/, a web application that creates searchable multimedia corpora from data collections in diverse formats, including collections of interlinearized glossed text (IGT) and dictionaries. There exists a crucial lacuna in the electronic ecology that supports language documentation and linguistic research. Vast amounts of IGT are produced in stand-alone programs without an easy way to share them publicly as dynamic databases. Solving this problem will not only unlock an enormous amount of linguistic information that can be shared easily across the web, it will also improve accountability by allowing us to verify analyses …

A New Hybrid Decision Support Tool For Evaluating The Sustainability Of Mining Projects, S. Kamenopoulos, Zacharias Agioutantis, K. Komnitsas

Mining Engineering Faculty Publications

The integration of sustainable development challenges and opportunities into the decision making process during the design and/or implementation of multi-disciplinary mining projects is generally not supported by decision support systems (DSS). A new hybrid decision support tool, which features an integrated assessment of sustainable development issues as they apply to mining projects, is hereby proposed. The proposed DSS framework, named “Acropolis DSS”, can be used to assist involved stakeholders in critical decisions, especially when addressing issues such as stakeholder participation, transparency, and trade-offs. The proposed DSS is based on a multi-criteria decision analysis combined with the multi-attribute utility theory.

The 3d Stress-Tensor Bootstrap, Anatoly Dymarsky, Filip Kos, Petr Kravchuk, David Poland, David Simmons-Duffin

Physics and Astronomy Faculty Publications

We study the conformal bootstrap for 4-point functions of stress tensors in parity-preserving 3d CFTs. To set up the bootstrap equations, we analyze the constraints of conformal symmetry, permutation symmetry, and conservation on the stress-tensor 4-point function and identify a non-redundant set of crossing equations. Studying these equations numerically using semidefinite optimization, we compute bounds on the central charge as a function of the independent coefficient in the stress-tensor 3-point function. With no additional assumptions, these bounds numerically reproduce the conformal collider bounds and give a general lower bound on the central charge. We also study the effect of gaps …

Three Dimensional View Of Arbitrary Q Syk Models, Sumit R. Das, Aminik Ghosh, Antal Jevicki, Kenta Suzuki

Physics and Astronomy Faculty Publications

In [15] it was shown that the spectrum and bilocal propagator of SYK model with four fermion interactions can be realized as a three dimensional model in AdS₂ ×S¹/Z₂ with nontrivial boundary conditions in the additional dimension. In this paper we show that a similar picture holds for generalizations of the SYK model with q-fermion interactions. The 3D realization is now given on a space whose metric is conformal to AdS₂ × S¹/Z₂ and is subject to a non-trivial potential in addition to a delta function at the center of …

Coexistence Of Ferromagnetism And Unconventional Spin-Glass Freezing In The Site-Disordered Kagome Ferrite Srsn2Fe4O11, L. Shlyk, S. Strobel, Barry Farmer, Lance E. De Long, R. Niewa

Physics and Astronomy Faculty Publications

Single-crystal x-ray diffraction refinements indicate SrSn₂Fe₄O₁₁ crystallizes in the hexagonal R-type ferrite structure with noncentrosymmetric space group P6₃mc and lattice parameters a = 5.9541(2)Å, c = 13.5761(5)Å, Z = 2 (R(F) = 0.034). Octahedrally coordinated 2a [M(1) and M(1a)] and 6c sites [M(2)] have random, mixed occupation by Sn and Fe; whereas the tetrahedrally coordinated 2b sites [Fe(3) and Fe(3a)] are exclusively occupied by Fe, whose displacement from the ideal position with trigonal-bipyramidal coordination causes the loss of inversion symmetry. …

Discussion And Survey, Conference Attendees

Kentucky Alfalfa and Stored Forage Conference

No abstract provided.

The Future Of Alfalfa: Understanding Gmo Traits And Their Impact On Production And Marketing, Phil Bollman

Kentucky Alfalfa and Stored Forage Conference

No abstract provided.

Emerging Export Markets For High Quality Alfalfa Hay, Tom Keene

Kentucky Alfalfa and Stored Forage Conference

The exporting of hay from country to country has been evolving for many years. When we look at today’s exports of American hay, we see that the majority of it takes place off the west coast.

Managing Frost Damaged Alfalfa Stands, Christopher D. Teutsch, Jimmy C. Henning, S. Ray Smith, Tom Keene, Matthew Dixon

Kentucky Alfalfa and Stored Forage Conference

Wide fluctuations in springtime temperature are common in Kentucky. Late freezing temperatures in the spring can cause damage to alfalfa depending on how far along it is in breaking dormancy. This publication provides information on the effect of low spring temperatures on both established and new alfalfa stands that have begun growth, as well as a method of predicting sensitivity to late frosts or freezes.

Harvesting Alfalfa For Quality, Garry D. Lacefield

Kentucky Alfalfa and Stored Forage Conference

Alfalfa can be harvested for hay, baleage, silage, greenchop or grazing. Our goal is to produce, harvest and market high yielding-high quality forage. Profitable alfalfa programs consist of four basic phases and each phase have a specific goal.

Integrated Management Of Alfalfa Diseases, Kiersten A. Wise

Kentucky Alfalfa and Stored Forage Conference

Alfalfa diseases can reduce forage quality and the longevity of alfalfa stands. Integrated management of diseases can minimize disease impact and improve forage stand and quality. There are several important pathogens that cause disease on alfalfa, and the occurrence of these diseases, as well as the severity of damage, depend on several factors, including the type of pathogen, the environment, and the level of resistance of the host to a particular disease. In addition, disease presence and severity are also influenced by agronomic practices, particularly sowing dates, cutting dates and frequency, and fertility programs.

An Integrated Pest Management Ipm Approach In Alfalfa Production Systems, Lee H. Townsend

Kentucky Alfalfa and Stored Forage Conference

Alfalfa lends itself to an integrated pest management (IPM) approach for alfalfa weevils and potato leafhoppers, the two key insect pests of the crop. Both species live in most alfalfa fields every summer. However, alfalfa can tolerate low levels of their feeding without costly yield or quality loss.

An Integrated Approach To Weed Control In Alfalfa Production Systems, Jonathan D. Green

Kentucky Alfalfa and Stored Forage Conference

The importance of weed control in forage production should not be overlooked, especially when you consider the high investment associated with alfalfa and other legume forages. Weeds reduce forage yield by competing for water, sunlight, and nutrients. For example, yield obtained from the first cutting of alfalfa can be significantly reduced by a heavy infestation of common chickweed. In addition to yield losses, weeds can also lower forage quality, increase the incidence of disease and insect problems, cause premature stand loss, and create harvesting problems. Some weeds are unpalatable to livestock or, in some cases, may be poisonous.

Fertilizing High Producing Alfalfa Stands, Edwin L. Ritchey

Kentucky Alfalfa and Stored Forage Conference

There are no secrets for successfully producing a high quality alfalfa crop. Successful alfalfa production is a product of suitable site selection, proper fertility and pH management, good pest control, and favorable weather conditions throughout the season. This paper focuses on proper fertility and pH management practices.

Alfalfa Establishment: Getting Off To A Good Start!, Christopher D. Teutsch

Kentucky Alfalfa and Stored Forage Conference

Alfalfa is a highly productive forage legume that is well adapted to transition zone states like Kentucky. It can be grazed, hayed, or ensiled. Once established and under good management, expected yields range from 5-7 tons per acre per year. High yields can only be obtained from a dense and vigorous alfalfa stand. The first step in obtaining such stands is establishment. The establishment phase of alfalfa production is critical since realization of returns from all other input costs is dependent upon having a good stand and it is expensive. It is important to remember that alfalfa establishment begins long …

Fine Tuning Varietal Selection For The Mid-South, S. Ray Smith

Kentucky Alfalfa and Stored Forage Conference

There are many new alfalfa varieties that have come on the market each year. In fact, it can be hard keeping up with all the developments. In the following pages I will overview most of the important traits that can be found in new varieties. These include Low Lignin, Roundup Ready®, potato leafhopper resistance, higher quality, resistance to new diseases, and more… Many times I am asked “Are new varieties really worth the cost?” The best way to answer that question is to consider work by Dr. Jimmy Henning where he summarized 24 location years of Kentucky alfalfa yield data …

Foreword Of Kentucky Alfalfa And Stored Forages Conference [2018], Christopher D. Teutsch, Christi L. Forsythe

Kentucky Alfalfa and Stored Forage Conference

No abstract provided.

Preventing Crossover In Redox Flow Batteries Through Active Material Oligomerization, Susan A. Odom

Chemistry Faculty Publications

No abstract provided.

Effect Of Molecular Side Groups And Local Nanoenvironment On Photodegradation And Its Reversibility, Nicole Quist, Mark Li, Ryan Tollefsen, Michael Haley, John Anthony, Oksana Ostroverkhova

Chemistry Faculty Publications

Degradation of organic semiconductors in the presence of oxygen is one of the bottlenecks preventing their wide-spread use in optoelectronic devices. The first step towards such degradation in functionalized pentacene (Pn) derivatives is formation of endoperoxide (EPO), which can either revert back to the parent molecule or proceed to molecule decomposition. We present the study of reversibility of EPO formation through probing the photophysical properties of functionalized fluorinated pentacene (Pn-R-F8) derivatives. Experiments are done in solutions and in films both at the single molecule level and in the bulk. In solutions, degradation of optical absorption and its partial recovery after …

Sdss-Iv Manga: Modelling The Metallicity Gradients Of Gas And Stars – Radially Dependent Metal Outflow Versus Imf, Jianhui Lian, Daniel Thomas, Claudia Maraston, Daniel Goddard, Taniya Parikh, J. G. Fernández-Trincado, Alexandre Roman-Lopes, Yu Rong, Baitian Tang, Renbin Yan

Physics and Astronomy Faculty Publications

In our previous work, we found that only two scenarios are capable of reproducing the observed integrated mass–metallicity relations for the gas and stellar components of local star-forming galaxies simultaneously. One scenario invokes a time-dependent metal outflow loading factor with stronger outflows at early times. The other scenario uses a time-dependent initial mass function (IMF) slope with a steeper IMF at early times. In this work, we extend our study to investigate the radial profile of gas and stellar metallicity in local star-forming galaxies using spatially resolved spectroscopic data from the SDSS-IV MaNGA survey. We find that most galaxies show …

Where Is Oh And Does It Trace The Dark Molecular Gas (Dmg)?, Di Li, Ningyu Tang, Hiep Nguyen, J. R. Dawson, Carl Heiles, Duo Xu, Zhichen Pan, Paul F. Goldsmith, Steven J. Gibson, Claire E. Murray, Tim Robishaw, N. M. Mcclure-Griffiths, John Dickey, Jorge Pineda, Snežana Stanimirović, L. Bronfman, Thomas Troland

Physics and Astronomy Faculty Publications

Hydroxyl (OH) is expected to be abundant in diffuse interstellar molecular gas because it forms along with H₂ under similar conditions and forms within a similar extinction range.

For the remainder of the abstract, please download this article or visit: https://doi.org/10.3847/1538-4365/aaa762

Variance Reduction And Cluster Decomposition, Keh-Fei Liu, Jian Liang, Yi-Bo Yang

Physics and Astronomy Faculty Publications

It is a common problem in lattice QCD calculation of the mass of the hadron with an annihilation channel that the signal falls off in time while the noise remains constant. In addition, the disconnected insertion calculation of the three-point function and the calculation of the neutron electric dipole moment with the θ term suffer from a noise problem due to the √V fluctuation. We identify these problems to have the same origin and the √V problem can be overcome by utilizing the cluster decomposition principle. We demonstrate this by considering the calculations of the glueball mass, the …

Individual And Combined Effects Of Herbicide Tribenuron-Methyl And Fungicide Tebuconazole On Soil Earthworm Eisenia Fetida, Jiqiang Chen, Muhammad Saleem, Caixia Wang, Wenxing Liang, Qingming Zhang

Plant and Soil Sciences Faculty Publications

Earthworms are soil engineers that alter the soil bio-physical properties to favor plant growth whereas pesticides represent a significant threat to their abundance and soil health. Thus, we investigated the toxic effects of tribenuron-methyl (TBM) and tebuconazole (TEB) on the soil earthworm, Eisenia fetida. The TBM demonstrated low toxicity to E. fetida in the contact filter paper and artificial soil tests, with median lethal concentrations (LC₅₀) of 135.6 μg cm⁻² at 48 h and 511 mg kg⁻¹ on day 14, respectively. Similarly, TEB also showed low toxicity to E. fetida in the artificial …

Electronic And Optical Properties Of La-Doped Sr3Ir2O7 Epitaxial Thin Films, Maryam Souri, Jsaminka Terzic, J. M. Johnson, John G. Connell, John H. Gruenewald, J. Thompson, Joseph W. Brill, J. Hwang, Gang Cao, Sung S. Ambrose Seo

Physics and Astronomy Faculty Publications

We have investigated structural, transport, and optical properties of tensile strained (Sr_1−xLa_x)₃Ir₂O₇ (x = 0, 0.025, 0.05) epitaxial thin films. While high-T_c superconductivity is predicted theoretically in the system, we have observed that all of the samples remain insulating with finite optical gap energies and Mott variable-range hopping characteristics in transport. Cross-sectional scanning transmission electron microscopy indicates that structural defects such as stacking faults appear in this system. The insulating behavior of the La-doped Sr₃Ir₂O₇ thin films is presumably due to disorder-induced …

Direct Collapse To Supermassive Black Hole Seeds With Radiative Transfer: Isolated Halos, Yang Luo, Kazem Ardaneh, Isaac Shlosman, Kentaro Nagamine, John H. Wise, Mitchell C. Begelman

Physics and Astronomy Faculty Publications

Direct collapse within dark matter haloes is a promising path to form supermassive black hole seeds at high redshifts. The outer part of this collapse remains optically thin. However, the innermost region of the collapse is expected to become optically thick and requires to follow the radiation field in order to understand its evolution. So far, the adiabatic approximation has been used exclusively for this purpose. We apply radiative transfer in the flux-limited diffusion (FLD) approximation to solve the evolution of coupled gas and radiation for isolated haloes. We find that (1) the photosphere forms at 10⁻⁶ pc and …

Distinct Properties Underlie Flavin-Based Electron Bifurcation In A Novel Electron Transfer Flavoprotein Fixab From Rhodopseudomonas Palustris, H. Diessel Duan, Carolyn E. Lubner, Monika Tokmina-Lukaszewska, George H. Gauss, Brian Bothner, Paul W. King, John W. Peters, Anne-Frances Miller

Chemistry Faculty Publications

A newly recognized third fundamental mechanism of energy conservation in biology, electron bifurcation, uses free energy from exergonic redox reactions to drive endergonic redox reactions. Flavin-based electron bifurcation furnishes low-potential electrons to demanding chemical reactions, such as reduction of dinitrogen to ammonia. We employed the heterodimeric flavoenzyme FixAB from the diazotrophic bacterium Rhodopseudomonas palustris to elucidate unique properties that underpin flavin-based electron bifurcation. FixAB is distinguished from canonical electron transfer flavoproteins (ETFs) by a second FAD that replaces the AMP of canonical ETF. We exploited near-UV–visible CD spectroscopy to resolve signals from the different flavin sites in FixAB and to …

Spectroscopic Characterization Of Galaxy Clusters In Rcs-1: Spectroscopic Confirmation, Redshift Accuracy, And Dynamical Mass–Richness Relation, David G. Gilbank, L. Felipe Barrientos, Erica Ellingson, Kris Blindert, H. K. C. Lee, T. Anguita, M. D. Gladders, P. B. Hall, G. Hertling, L. Infante, Renbin Yan, M. Carrasco, Cristina Garcia-Vergara, K. S. Dawson, C. Lidman, T. Morokuma

Physics and Astronomy Faculty Publications

We present follow-up spectroscopic observations of galaxy clusters from the first Red-sequence Cluster Survey (RCS-1). This work focuses on two samples, a lower redshift sample of ∼30 clusters ranging in redshift from z ∼ 0.2–0.6 observed with multiobject spectroscopy (MOS) on 4–6.5-m class telescopes and a z ∼ 1 sample of ∼10 clusters 8-m class telescope observations. We examine the detection efficiency and redshift accuracy of the now widely used red-sequence technique for selecting clusters via overdensities of red-sequence galaxies. Using both these data and extended samples including previously published RCS-1 spectroscopy and spectroscopic redshifts from SDSS, we find that …

Beam-Energy Dependence Of Directed Flow Of Λ, Λ¯, K±, K0S, And Φ In Au + Au Collisions, L. Adamczyk, J. R. Adams, James K. Adkins, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, N. N. Ajitanand, I. Alekseev, D. M. Anderson, R. Aoyama, A. Aparin, D. Arkhipkin, E. C. Aschenauer, M. U. Ashraf, A. Attri, G. S. Averichev, X. Bai, V. Bairathi, K. Barish, A. Behera, R. Bellwied, A. Bhasin, A. K. Bhati, P. Bhattarai, J. Bielcik, J. Bielcikova, L. C. Bland, I. G. Bordyuzhin, J. Bouchet, J. D. Brandenburg, Renee H. Fatemi, Suvarna Ramachandran

Physics and Astronomy Faculty Publications

Rapidity-odd directed-flow measurements at midrapidity are presented for Λ, Λ¯, K^±, K⁰_s, and ϕ at √s_NN = 7.7, 11.5, 14.5, 19.6, 27, 39, 62.4, and 200 GeV in Au + Au collisions recorded by the Solenoidal Tracker detector at the Relativistic Heavy Ion Collider. These measurements greatly expand the scope of data available to constrain models with differing prescriptions for the equation of state of quantum chromodynamics. Results show good sensitivity for testing a picture where flow is assumed to be imposed before hadron formation and the observed particles are assumed to form …

What Makes The Family Of Barred Disc Galaxies So Rich: Damping Stellar Bars In Spinning Haloes, Angela Collier, Isaac Shlosman, Clayton Heller

Physics and Astronomy Faculty Publications

We model and analyse the secular evolution of stellar bars in spinning dark matter (DM) haloes with the cosmological spin λ ∼ 0–0.09. Using high-resolution stellar and DM numerical simulations, we focus on angular momentum exchange between stellar discs and DM haloes of various axisymmetric shapes – spherical, oblate, and prolate. We find that stellar bars experience a diverse evolution that is guided by the ability of parent haloes to absorb angular momentum, J, lost by the disc through the action of gravitational torques, resonant and non-resonant. We confirm that dynamical bar instability is accelerated via resonant J-transfer …