Physical Sciences and Mathematics Commons^™

An Improved Source Of Spin-Polarized Electrons Based On Spin Exchange In Optically Pumped Rubidium Vapor, K. J. Ahrendsen, Kenneth Wayne Trantham, D. Tupa, T. J. Gay

Department of Physics and Astronomy: Faculty Publications

We have improved a polarized electron source in which unpolarized electrons undergo collisions with a mixture of buffer gas molecules and optically spin-polarized Rb atoms. With a nitrogen buffer gas, the source reliably provides spin polarization between 15% and 25% with beam currents >4 μA. Vacuum pump upgrades mitigate problems caused by denatured diffusion pump oil, leading to longer run times. A new differential pumping scheme allows the use of higher buffer gas pressures up to 800 mTorr. With a new optics layout, the Rb polarization is continuously monitored by a probe laser and improved pump laser power provides more …

Search For Magnetoelectric Monopole Response In Cr2O3 Powder, Syed Qamar Abbas Shah, Ather Mahmood, Arun Parthasarathy, Christian H. Binek

Department of Physics and Astronomy: Faculty Publications

Powder samples have been suggested as a pathway to fabricate isotropic magnetoelectric (ME) materials which effectively only have a pseudoscalar or monopole ME response. We demonstrate that random distribution of ME grains alone does not warrant isotropic ME response because the activation of a nonvanishing ME response requires a ME field cooling protocol which tends to induce preferred axes.We investigate the evolution of ME susceptibility in powder chromia samples for various ME field cooling protocols both theoretically and experimentally. In particular, we work out the theoretical expressions for ME susceptibility for powder chromia in the framework of statistical mechanics where …

The Patchwork Governance Of Ecologically Available Water: A Case Study In The Upper Missouri Headwaters, Montana, United States, Amanda E. Cravens, Julia B. Goolsby, Theresa Jedd, Deborah J. Bathke, Shelley Crausbay, Ashley E. Cooper, Jason Dunham, Tonya Haigh, Kimberly R. Hall, Michael J. Hayes, Jamie Mcevoy, Rebecca L. Nelson, Markéta Poděbradská, Aaron Ramirez, Elliot Wickham, Dionne Zoanni

Drought Mitigation Center: Faculty Publications

Institutional authority and responsibility for allocating water to ecosystems (“ecologically available water” [EAW]) is spread across local, state, and federal agencies, which operate under a range of statutes, mandates, and planning processes. We use a case study of the Upper Missouri Headwaters Basin in southwestern Montana, United States, to illustrate this fragmented institutional landscape. Our goals are to (a) describe the patchwork of agencies and institutional actors whose intersecting authorities and actions influence the EAW in the study basin; (b) describe the range of governance mechanisms these agencies use, including laws, policies, administrative programs, and planning processes; and (c) assess …

A Sensitivity Study Of Triboson Production Processes To Dimension-6 Eft Operators At The Lhc, R. Bellan, S. Bhattacharya, G. Boldrini, F. Cetorelli, P. Govoni, A. Massironi, A. Mecca, C. Tarricone, A. Vagnerini

Department of Physics and Astronomy: Faculty Publications

We present the first parton-level study of anomalous effects in triboson production in both fully and semi-leptonic channels in proton-proton collisions at 13TeV at the Large Hadron Collider (LHC). The sensitivity to anomalies induced by a minimal set of bosonic dimension-6 operators from the Warsaw basis is evaluated with specific analyses for each final state. A likelihood-based strategy is employed to assess the most sensitive kinematic observables per channel, where the contribution of Effective Field Theory operators is parameterized at either the linear or quadratic level. The impact of the mutual interference terms of pairs of operators on the sensitivity …

A Search For Decays Of The Higgs Boson To Invisible Particles In Events With A Top-Antitop Quark Pair Or A Vector Boson In Proton-Proton Collisions At √S = 13 Tev, Armen R. Tumasyan

Department of Physics and Astronomy: Faculty Publications

The first search for nonresonant production of Higgs boson pairs (HH) with one H decaying into four leptons and the other into a pair of b quarks is presented, using proton-proton collisions recorded at a center-of-mass energy of √s = 13 TeV by the CMS experiment. The analyzed data correspond to an integrated luminosity of 138 fb⁻¹. A 95% confidence level upper limit of 32.4 is set on the signal strength modifier μ, defined as the ratio of the observed HH production rate in the HH → ZZ*bb → 4ℓbb decay channel to the standard model …

Initial Experience With An Electron Flash Research Extension (Flex) For The Clinac System, Kyuhak Oh, Kyle J. Gallagher, Megan Hyun, Diane Schott, Sarah Wisnoskie, Yu Lei, Samuel Hendley, Jeffrey Wong, Shuo Wang, Brendan Graff, Christopher Jenkins, Frank Rutar, Md Ahmed, Joshua Mcneur, Jeffrey Taylor, Marty Schmidt, Lasitha Senadheera, Wendy Smith, Subodh M. Lele, Ran Dai, Dong Jianghu (James), Y Yan, Su-Min Zhou

Department of Physics and Astronomy: Faculty Publications

Purpose: Radiotherapy delivered at ultra-high-dose-rates (≥40 Gy/s), that is, FLASH, has the potential to effectively widen the therapeutic window and considerably improve the care of cancer patients. The underlying mechanism of the FLASH effect is not well understood, and commercial systems capable of delivering such dose rates are scarce. The purpose of this study was to perform the initial acceptance and commissioning tests of an electron FLASH research product for preclinical studies.

Methods: A linear accelerator (Clinac 23EX) was modified to include a nonclinical FLASH research extension (the Clinac-FLEX system) by Varian, a Siemens Healthineers company (Palo Alto, …

Introducing High School Biology Students To Biochemistry With A Short, Content-Oriented Module, Archer Harrold, Allison Cruikshank, Bryan Penas, Rebecca Roston

Chemistry Department: Faculty Publications

Many STEM disciplines are underrepresented to High School students. This is problematic as many students' decisions for college are shaped by their experiences and achievements in high school. Short content-oriented modules have been shown to encourage science identity and otherwise benefit the students' learning. Following the ASBMB's outreach protocol, we developed a short content-oriented module aimed at a high school biology classroom. Students interacted with 3D models of DNA and transcription factors while exploring structure–function relationships and introductory biochemistry topics. The high school teacher was impressed with the students' response to the module, specifically the ease with which students learned, …

A Variational Theory For Integral Functionals Involving Finite-Horizon Fractional Gradients, Javier Cueto, Carolin Carolin, Hidde Schönberger

Department of Mathematics: Faculty Publications

The center of interest in this work are variational problems with integral functionals depending on nonlocal gradients with finite horizon that correspond to truncated versions of the Riesz fractional gradient. We contribute several new aspects to both the existence theory of these problems and the study of their asymptotic behavior. Our overall proof strategy builds on finding suitable translation operators that allow to switch between the three types of gradients: classical, fractional, and nonlocal. These provide useful technical tools for transferring results from one setting to the other. Based on this approach, we show that quasiconvexity, which is the natural …

Evaluation Of Native Plant Communities On Nebraska Game And Parks Commission State Parks, Robert F. Steinauer

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

This report evaluates the Native Plant Communities on Nebraska Game and Parks Commission State Parks East Region, also known as Region 3, which includes much of northeast and extreme eastern Nebraska, including portions of the lower Niobrara, Elkhorn and Platte Rivers and nearly the entire east border formed by the Missouri River. Fifteen state-listed threatened and endangered species have been recorded within the boundaries of Region 3 within the last twenty years. Several of these occupy habitats within major river channels.

Surveyed areas which contained habitat for legally protected species include Dead Timber State Recreation Area, Indian Cave State Park, …

Changes In An Enzyme Ensemble During Catalysis Observed By High Resolution Xfel Crystallography, Nathan J. Smith, Medhanjali Dasgupta, David C. Wych, Cole Dolamore, Raymond G. Sierra, Stella Lisova, Darya Marchany-Rivera, Aina E. Cohen, Sébastien Boutet, Mark S. Hunter, Christopher Kupitz, Frédéric Poitevin, Frank R. Moss Iii, Aaron S. Brewster, Nicholas K. Sauter, Iris D. Young, Alexander M. Wolff, Virendra K. Tiwari, Nivesh Kumar, David B. Berkowitz, Ryan G. Hadt, Michael C. Thompson, Alec H. Follmer, Mark A. Wilson

Chemistry Department: Faculty Publications

Enzymes populate ensembles of structures with intrinsically different catalytic proficiencies that are difficult to experimentally characterize. We use time-resolved mix-and-inject serial crystallography (MISC) at an X-ray free electron laser (XFEL) to observe catalysis in a designed mutant (G150T) isocyanide hydratase (ICH) enzyme that enhances sampling of important minor conformations. The active site exists in a mixture of conformations and formation of the thioimidate catalytic intermediate selects for catalytically competent substates. A prior proposal for active site cysteine charge-coupled conformational changes in ICH is validated by determining structures of the enzyme over a range of pH values. A combination of large …

Magnetic Nanodoping: Atomic Control Of Spin States In Cobalt Doped Silver Clusters, Vicente Zamudio-Bayer, Konstantin Hirsch, Lei Ma, Kobe De Knijf, X. S. Xu, Arkadiusz Ławicki, Akira Terasaki, Piero Ferrari, Bernd Von Issendorff, Peter Lievens, Walt A. De Heer, J. Tobias Lau, Ewald Janssens

Department of Physics and Astronomy: Faculty Publications

The interaction of magnetic dopants with delocalized electron states can result in interesting many-body physics. Here, the magnetic properties of neutral and charged finite silver metal host clusters with a magnetic cobalt atom impurity were investigated experimentally by exploiting the complementary methods of Stern- Gerlach molecular beam deflection and x-ray magnetic circular dichroism spectroscopy and are accompanied by density functional theory calculations and charge transfer multiplet simulations. The influence of the number of valence electrons and the consequences of impurity encapsulation were addressed in free size-selected, singly cobalt-doped silver clusters CoAg^0,_n+ (n = 2–15). Encapsulation of the …

A Search For Chiral Asymmetry In Secondary Electron Emission From Cysteine Induced By Longitudinally Polarized Electrons, K. J. Ahrendsen, Kenneth Wayne Trantham, D. Tupa, T. J. Gay

Department of Physics and Astronomy: Faculty Publications

We performed experiments searching for chirality-dependent secondary electron emission for a 141 eV longitudinally spin-polarized electron beam incident on a thick solid cysteine target. We determined the secondary electron yield by measuring the positive current produced when the cysteine target was negatively biased. No spin-dependent effects to a level of 10⁻³ were found for the secondary electron emission yield.

On The Boundary Of The Cosmos, Daniel Linford

Chemistry Department: Faculty Publications

Intuitively, the totality of physical reality – the Cosmos – has a beginning only if (i) all parts of the Cosmos agree on the direction of time (the Direction Condition) and (ii) there is a boundary to the past of all non-initial spacetime points such that there are no spacetime points to the past of the boundary (the Boundary Condition). Following a distinction previously introduced by J. Brian Pitts, the Boundary Condition can be conceived of in two distinct ways: either topologically, i.e., in terms of a closed boundary, or metrically, i.e., in terms of the Cosmos having a finite …

Electrically Induced Cancellation And Inversion Of Piezoelectricity In Ferroelectric Hf0.5Zr0.5O2, Haidong Lu, Dong-Jik Kim, Hugo Aramberri, Marco Holzer, Pratyush Buragohain, Sangita Dutta, Uwe Schroeder, Veeresh Deshpande, Jorge Íñiguez, Alexei Gruverman, Catherine Dubourdieu

Department of Physics and Astronomy: Faculty Publications

HfO2-based thin films hold huge promise for integrated devices as they show full compatibility with semiconductor technologies and robust ferroelectric properties at nanometer scale. While their polarization switching behavior has been widely investigated, their electromechanical response received much less attention so far. Here, we demonstrate that piezoelectricity in Hf_0.5Zr_0.5O₂ ferroelectric capacitors is not an invariable property but, in fact, can be intrinsically changed by electrical field cycling. Hf_0.5Zr_0.5O₂ capacitors subjected to ac cycling undergo a continuous transition from a positive effective piezoelectric coefficient d₃₃ in the pristine state to …

The Devil You Know And The Devil You Don’T: Current Status And Challenges Of Bovine Tuberculosis Eradication In The United States, Daniel J. O'Brien, Tyler C. Thacker, Liliana C.M. Salvador, Anthony G. Duffiney, Suelee Robbe‑Austerman, Mark S. Camacho, Jason E. Lombard, Mitchell V. Palmer

United States Department of Agriculture Wildlife Services: Staff Publications

Having entered into its second century, the eradication program for bovine tuberculosis (bTB, caused by Mycobacterium bovis) in the United States of America occupies a position both enviable and daunting. Excepting four counties in Michigan comprising only 6109 km2 (0.06% of US land area) classified as Modified Accredited, as of April 2022 the entire country was considered Accredited Free of bTB by the US Department of Agriculture for cattle and bison. On the surface, the now well-described circumstances of endemic bTB in Michigan, where white-tailed deer (Odocoileus virginianus) serve as a free-ranging wildlife maintenance host, may appear to be …

Topological Hall Effect In Particulate Magnetic Nanostructure, Ahsan Ullah

Department of Physics and Astronomy: Dissertations, Theses, and Student Research

Conduction electrons change their spin direction due to the exchange interaction with the lattice spins. Ideally, the spins of the conduction electrons follow the atomic spin adiabatically, so that spins like S1, S2, and S3 can be interpreted as time-ordered sequences t1 < t2 < t3. Such spin sequences yield a quantum-mechanical phase factor in the wave function,  →ei, where  is known as the Berry phase. The corresponding spin rotation translates into a Berry curvature and an emergent magnetic field and subsequently, Hall-effect contribution known as the topological Hall-effect. This dissertation explores topological Hall-effect in particulate magnets, where noncollinear spins are stabilized by competition between different magnetic interactions. The topologically non-trivial spin textures in these nanostructures are flower states, curling states, vortex, and magnetic bubbles, which give rise to topological Hall-effect and have finite spin chirality and Skyrmion number Q. Topological Hall-effect is investigated in noninteracting nanoparticles, exchanges coupled centrosymmetric nanoparticles, exchanges coupled non-centrosymmetric nanoparticles which possess Dzyaloshinskii-Moriya interaction (DMI), and exchanged coupled Hard and soft magnetic films. Micromagnetic modeling, simulations, analytical calculations, and experimental methods are used to determine topological Hall-effect. In very small noninteracting nanoparticles, the reverse magnetic fields enhance Q due to the flower state until the reversal occurs, whereas, for particles with a radius greater than coherence radius, the Q jumps to a larger value at the nucleation field representing the curling state. The comparisons of magnetization patterns between experimental and computed magnetic force microscopy (MFM) measurements show the presence of spin chirality. Magnetic and Hall-effect measurements identify topological Hall-effect in the exchange-coupled Co and CoSi-nanoparticle films. The origin of the topological Hall-effect namely, the chiral domains with domain-wall chirality quantified by an integer skyrmion number in Co and chiral spins with partial skyrmion number in CoSi. These spin structures are different from the Skyrmions due to DMI in B-20 crystals and multilayered thin films with Cnv symmetry. In these films THE caused by cooperative magnetization reversal in the exchange-coupled Co-nanoparticles and peripheral chiral spin textures in CoSi-nanoparticles.

Advisor: Xiaoshan Xu

Functional Connectivity Varies Across Scales In A Fragmented Landscape, Kate I. T. Bird, Daniel R. Uden, Craig R. Allen

School of Natural Resources: Faculty Publications

Species of different sizes interact with the landscape differently because ecological structure varies with scale, as do species movement capabilities and habitat requirements. As such, landscape connectivity is dependent upon the scale at which an animal interacts with its environment. Analyses of landscape connectivity must incorporate ecologically relevant scales to address scale-specific differences. Many evaluations of landscape connectivity utilize incrementally increasing buffer distances or other arbitrary spatial delineations as scales of analysis. Instead, we used a mammalian body mass discontinuity analysis to objectively identify scales in the Central Platte River Valley (CPRV) of Nebraska, U.S.A. We implemented a graph-theoretic network …

Machine Learning Techniques To Predict The Air Quality Using Meteorological Data In Two Urban Areas In Sri Lanka, Lakindu Mampitiya, Namal Rathnayake, Lee P. Leon, Vishwanadham Mandala, Hazi Md. Azamathulla, Sherly Shelton, Yukinobu Hoshino, Upaka Rathnayake

Department of Earth and Atmospheric Sciences: Faculty Publications

The effect of bad air quality on human health is a well-known risk. Annual health costs have significantly been increased in many countries due to adverse air quality. Therefore, forecasting air quality-measuring parameters in highly impacted areas is essential to enhance the quality of life. Though this forecasting is usual in many countries, Sri Lanka is far behind the state-of-the-art. The country has increasingly reported adverse air quality levels with ongoing industrialization in urban areas. Therefore, this research study, for the first time, mainly focuses on forecasting the PM₁₀ values of the air quality for the two urbanized areas …

Search For Higgs Boson Decay To A Charm Quark-Antiquark Pair In Proton-Proton Collisions At √S =13 Tev, A. Tumasyan

Department of Physics and Astronomy: Faculty Publications

A search for the standard model Higgs boson decaying to a charm quark-antiquark pair, H → c[], produced in association with a leptonically decaying V (W or Z) boson is presented. The search is performed with proton-proton collisions at √s = 13 TeV collected by the CMS experiment, corresponding to an integrated luminosity of 138 fb⁻¹. Novel charm jet identification and analysis methods using machine learning techniques are employed. The analysis is validated by searching for Z → c[] in VZ events, leading to its first observation at a hadron collider with a significance …

Communication In The Science-Policy Interface: Evidence From A Boundary Organization In Nebraska, Usa, Sechindra Vallury, Brian C. Chaffin, Samantha L. Hamlin, Craig R. Allen

School of Natural Resources: Faculty Publications

Boundary organizations have a crucial function in environmental governance by facilitating the processes through which scientists and decision-makers generate, exchange, evaluate, and utilize knowledge to identify societal problems, propose potential solutions, and make decisions on appropriate courses of action. This support for evidence-informed decision making is essential in addressing environmental challenges effectively. Despite the growing popularity of boundary organizations, there remains a significant challenge in designing information dissemination platforms to bridge the communication divide between scientific experts and non-experts. To address this gap, we used natural language processing tools to analyze the communication strategies of a specific boundary organization — …

Early Career Aquatic Scientists Forge New Connections At Eco-Das Xv, Olivia J. Graham, Alia Al-Haj, Eleanor C. Arrington, Emily R. Arsenault, Carolina C. Barbosa, Kadir Bice, Evie Brahmstedt, S. River D. Bryant, Xun Cai, Stacy Calhoun-Grosch, Joshua Culpepper, Katherine Dale, Derek J. Detweiler, Katlin D. Doughty, Kyle A. Emery, Kara Gadeken, Laura Griffiths, Atefeh Hosseini, Catriona Jones, Hadis Miraly, Alexander W. Mott, Karla Münzner, Igor Ogashawara, Carly R. Olson, Joseph S. Rabaey, Walter A. Rich, Phoenix A. Rogers, Meredith Evans Seeley, Lorena Selak, Qipei Shangguan, Kelsey J. Solomon, Xinyu Sun, Spencer J. Tassone, Audrey Thellman, John Tracey, Jilian Xiong, Tianfei Xue

School of Natural Resources: Faculty Publications

A sense of kuleana (personal responsibility) in caring for the land and sea. An appreciation for laulima (many hands cooperating). An understanding of aloha ’āina (love of the land). The University of Hawai’i at Manoa hosted the 2023 Ecological Dissertations in Aquatic Sciences (Eco-DAS) program, which fostered each of these intentions by bringing together a team of early career aquatic ecologists for a week of networking and collaborative, interdisciplinary project development (Fig. 1).

Cooler Forests In Clean Air, Liang Chen

Department of Earth and Atmospheric Sciences: Faculty Publications

Improving air quality by reducing atmospheric aerosols can bring valuable health benefits, but also generally leads to warming. Now, research suggests that in cleaner air the local cooling effect of planting trees may be stronger in middle and low latitude regions.

Forests provide a substantial sink for atmospheric carbon and therefore have great potential for contributing to climate change mitigation globally.¹ Meanwhile, forests play an important role in local and regional climate through their effects on albedo, evapotranspiration, and surface roughness.² The biogeophysical mechanisms driving forest-climate feedback depend strongly on the local background climate. But it remains unclear …

Exploring Experimental Design And Multivariate Analysis Techniques For Evaluating Community Structure Of Bacteria In Microbiome Data, Kelsey Karnik

Department of Statistics: Dissertations, Theses, and Student Work

The gut microbiome plays a crucial role in human health, and by working collaboratively with microbiologists, we aim to further our understanding of the human gut and its impact on human health. Promoting a diverse microbiome is emphasized throughout microbiology literature, and involving a statistician in designing experiments to relate gut bacteria and some measured health outcome is crucial for ensuring valid and accurate results. By adopting new experimental design and analysis methods, researchers can begin to gain a deeper understanding of how the genetics of our food affect the composition of taxa within the gut microbiome. This dissertation is …

Understanding The Factors Affecting Nebraskan Farmers’ And Landowners' Decision To Adopt Precision Agricultural Technologies And Programs, Corrin C. Winter

School of Natural Resources: Dissertations, Theses, and Student Research

Advisors: Andrew Little, Christopher Chizinski

To gain insights into the challenges faced by Nebraska farmers and landowners when adopting precision agriculture technologies, I analyzed data collected from a 2022 survey involving 7,503 participants, consisting of producers and farmland owners from across the state of Nebraska. The primary objective was to provide valuable insights for agencies seeking to improve their precision agriculture and conservation outreach efforts for the benefit of conservation and Nebraskan farmers and landowners. This study aimed to understand key factors influencing adoption behaviors by evaluating the constraints to precision agriculture adoption, assessing the impact of producer and landowner …

Growth And Emergent Functionalities Of Oxide Thin Films Utilizing Interface Engineering, Detian Yang

Department of Physics and Astronomy: Dissertations, Theses, and Student Research

Complex oxide interfaces have offered intriguing novel emergent phenomena and multiple functionalities through interfacial reconstructions of spin, orbital, charge, and lattice degrees of freedom. Interface engineering via manipulating interfacial interaction, defects and multiple interfacial quantum charges and orders constitutes the essential method and technique to achieve desired functionalities in oxide heterostructures. In this thesis, shown are two examples of utilizing interfacial reconstruction and interfacial strain engineering to achieve intrinsic exchange bias and realize epitaxial growth of mixed-valence hexagonal manganite thin films, respectively.

Firstly, we demonstrated intrinsic exchange bias induced by interfacial reconstruction in Ni_xCo_yFe_3-x-yO …

Leveraging Eco-Evolutionary Models For Gene Drive Risk Assessment, Matthew A. Combs, Andrew J. Golnar, Justin M. Overcash, Alun L. Lloyd, Keith R. Hayes, David A. O'Brochta, Kim M. Pepin

United States Department of Agriculture Wildlife Services: Staff Publications

Engineered gene drives create potential for both widespread benefits and irreversible harms to ecosystems. CRISPR-based systems of allelic conversion have rapidly accelerated gene drive research across diverse taxa, putting field trials and their necessary risk assessments on the horizon. Dynamic processbased models provide flexible quantitative platforms to predict gene drive outcomes in the context of system-specific ecological and evolutionary features. Here, we synthesize gene drive dynamic modeling studies to highlight research trends, knowledge gaps, and emergent principles, organized around their genetic, demographic, spatial, environmental, and implementation features. We identify the phenomena that most significantly influence model predictions, discuss limitations of …

Azimuthal Correlations Within Exclusive Dijets With Large Momentum Transfer In Photon-Lead Collisions, A. Tumasyan

Department of Physics and Astronomy: Faculty Publications

The structure of nucleons is multidimensional and depends on the transverse momenta, spatial geometry, and polarization of the constituent partons. Such a structure can be studied using high-energy photons produced in ultraperipheral heavy-ion collisions. The first measurement of the azimuthal angular correlations of exclusively produced events with two jets in photon-lead interactions at large momentum transfer is presented, a process that is considered to be sensitive to the underlying nuclear gluon polarization. This study uses a data sample of ultraperipheral lead-lead collisions at √s_NN = 5.02 TeV, corresponding to an integrated luminosity of 0.38 nb⁻¹, collected with …

Differential Membrane Binding Of Α/Β-Peptide Foldamers: Implications For Cellular Delivery And Mitochondrial Targeting, Tzong-Hsien Lee, James W. Checco, Tess Malcolm, Chelcie H. Eller, Ronald T. Raines, Samuel H. Gellman, Erinna F. Lee, W. Douglas Fairlie, Marie-Isabel Aguilar

Chemistry Department: Faculty Publications

The intrinsic pathway of apoptosis is regulated by the Bcl-2 family of proteins. Inhibition of the anti-apoptotic members represents a strategy to induce apoptotic cell death in cancer cells. We have measured the membrane binding properties of a series of peptides, including modified α/β-peptides, designed to exhibit enhanced membrane permeability to allow cell entry and improved access for engagement of Bcl-2 family members. The peptide cargo is based on the pro-apoptotic protein Bim, which interacts with all anti-apoptotic proteins to initiate apoptosis. The α/β-peptides contained cyclic β-amino acid residues designed to increase their stability and membrane-permeability. Dual polarisation interferometry was …

Experimental Study Of Linux Flightsize Estimation, Mingrui Zhang

Department of Computer Science and Engineering: Dissertations, Theses, and Student Research

Transmission Control Protocol (TCP) is a fundamental Internet protocol responsible for controlling and coordinating the Internet traffic. As a result, TCP significantly influences the overall performance and stability of the Internet. One critical information required by a TCP connection to make decisions is FlightSize, which is the total amount of outstanding data contributed by the connection to the Internet. The FlightSize information is used by a TCP connection to determine its future sending rate and also avoid traffic congestion and collapse in the Internet. Consequently, an inaccurate estimation of FlightSize can result in degraded performance and instability of the Internet. …

Idempotent Completions Of Equivariant Matrix Factorization Categories, Michael K. Brown, Mark E. Walker

Department of Mathematics: Faculty Publications

We prove that equivariant matrix factorization categories associated to henselian local hypersurface rings are idempotent complete, generalizing a result of Dyckerhoff in the non- equivariant case.