Physical Sciences and Mathematics Commons^™

Machine Learning Approach For Predicting Cancer Using Gene Expression, Aashi Maharjan

UNLV Theses, Dissertations, Professional Papers, and Capstones

Cancer has become one of the major factors responsible for global deaths, due to late diagnoses and lack of proper treatment. It involves the abnormal and uncontrolled growth of cells inside the body, which might spread from one place to different parts. Ribonucleic acid (RNA) sequencing can detect the changes occurring inside cells and helps to analyze the transcriptome of gene expression patterns inside RNA. Machine learning techniques can assist in the prediction of cancer at an early stage, if data is available. The objective of this thesis is to build models and classify different types of cancer. For this …

Studies On Kernels Of Simple Polygons, Jason Mark

UNLV Theses, Dissertations, Professional Papers, and Capstones

The kernel of a simple polygon is the set of points in its interior from which all points inside the polygon are visible. We formally establish that for a given convex polygon Q we can always construct a larger simple polygon with many reflex vertices such that Q is the kernel of P. We present algorithms for decomposing a strongly monotone polygon into star-polygons. This decomposition is applied for developing an efficient algorithm for placing a small number of vertical towers to cover the entire given 1.5D terrain. We also present an experimental investigation of the proposed algorithm. The implementation …

An Ideological Criticism Of The Green New Deal And Media Responses, Corynn Miller

UNLV Theses, Dissertations, Professional Papers, and Capstones

Using an ecofeminist lens, this project aims to analyze the ideologies surrounding the creation and response to the Green New Deal (GND). By completing an ideological analysis of the GND, in addition to examining some news media portrayals of the GND, this thesis analyzes the underlying motivations and ideologies surrounding female politicians, climate change, and climate policies. This thesis examines reads the GND not as a policy that was meant to be passed, but instead as an ideological statement about humans and their relationship to the environment. The news media portrayals exhibit varying coverage of the GND’s effectiveness, varying use …

Abiotic, Biotic, And Bio-Enhanced Reduction Of Hexavalent Chromium, Chloroform And Co-Contaminants Using Nano-Scale Zero Valent Iron In Highly Contaminated Groundwater, Eduardo Robleto Martinez

UNLV Theses, Dissertations, Professional Papers, and Capstones

Investigations of groundwater in a former industrial perchlorate manufacturing site have shown high contamination with perchlorate, chlorate, nitrate, hexavalent chromium (Cr (VI)), and chloroform (CF) with levels greater than 3,000, 30,000, 300, 100, and 4 mg/L, respectively. Remediation efforts using biological reduction to desired contaminant levels at this site has been challenging due to high contaminant concentrations, and high total dissolved solids (TDS). Furthermore, removal of Cr(VI) and CF in the presence of nitrate, chlorate, and perchlorate has not been examined at the contaminated site. Nano-scale Zero-Valent-Iron (NZVI) has been effective at reducing groundwater contamination both with and without bacterial …

Infiltration Into Water-Repellent Sand: The Role Of Sorptivity, Rose Marie Shillito

UNLV Theses, Dissertations, Professional Papers, and Capstones

Soil water repellency (SWR) is believed to contribute to the increased potential for post-fire runoff and erosion. Currently, no quantitative method exists to account for SWR in physically-based runoff models. A physically-based model incorporating SWR (through the contact angle) in the infiltration parameter, sorptivity, was developed. The model was tested and verified with controlled laboratory tests on a fully characterized sand treated to create various degrees of SWR. The ability to create the wetting water characteristic curve for untreated and treated sand, appropriate for the infiltration process, was presented. Additionally, the ability to measure sorptivity with widely used infiltration tests …

Uncertainty Quantification For Maxwell's Equations, Zhiwei Fang

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation study three different approaches for stochastic electromagnetic fields based on the time domain Maxwell's equations and Drude's model: stochastic Galerkin method, stochastic collocation method, and Monte Carlo class methods. For each method, we study its regularity, stability, and convergence rates. Numerical experiments have been presented to verify our theoretical results. For stochastic collocation method, we also simulate the backward wave propagation in metamaterial phenomenon. It turns out that the stochastic Galerkin method admits the best accuracy property but hugest computational workload as the resultant PDEs system is usually coupled. The Monte Carlo class methods are easy to implement …

Characterization Of Beryllium Ion Complexation In The Presence Of Biological Buffers Using Isothermal Titration Calorimetry, Guillermo Alexander Ramirez

UNLV Theses, Dissertations, Professional Papers, and Capstones

Be2+ ion is a biologically active metal that is capable of binding to proteins and has been shown to affect various cellular processes. When treated with Be2+, certain cancer cells display cytostatic effects. GSK3β is a regulatory kinase involved in the β-catenin pathway that may be involved in producing these cytostatic effects when Be2+ binds to it. In order to determine binding parameters between Be2+ and GSK3β, isothermal titration calorimetry (ITC) can be utilized. However, titrations at physiological pH cannot be carried out due to Be2+ unique speciation at neutral pH ranges. Significant precipitation occurs at pH 6 and higher …

Chemical And Electronic Surface Structure Of Chalcopyrite-Based Thin Films For Solar Water Splitting, James C. Carter

UNLV Theses, Dissertations, Professional Papers, and Capstones

In recent years, various thin film solar devices have reached markedly high efficiencies on both the laboratory and large area scale. To further evaluate their potential, and help drive device optimization of efficient solar devices, a detailed understanding of the chemical and electronic structure of the surfaces and interfaces is required. It is these interfaces that play a pivotal role in dictating aspects of device performance. Chalcopyrite-based materials, such as Cu(In,Ga)S2 (CIGS) are regarded as one of the most promising absorber materials for use in highly efficient solar devices. In the context of photoelectrochemical (PEC) hydrogen generation, the tunability of …

Accurate Confidence Intervals For Risk Difference In Meta-Analysis With Rare Events, Tao Jiang, Baixin Cao, Guogen Shan

Environmental & Occupational Health Faculty Publications

Background: Meta-analysis provides a useful statistical tool to effectively estimate treatment effect from multiple studies. When the outcome is binary and it is rare (e.g., safety data in clinical trials), the traditionally used methods may have unsatisfactory performance. Methods: We propose using importance sampling to compute confidence intervals for risk difference in meta-analysis with rare events. The proposed intervals are not exact, but they often have the coverage probabilities close to the nominal level. We compare the proposed accurate intervals with the existing intervals from the fixed- or random-effects models and the interval by Tian et al. (2009). Results: We …

Swift Spectroscopy Of The Accretion Disk Wind In The Black Hole Gro J1655-40, M. Balakrishnan, J. M. Miller, N. Trueba, M. Reynolds, J. Raymond, Daniel Proga, A. C. Fabian, T. Kallman, J. Kaastra

Physics & Astronomy Faculty Research

Chandra obtained two High Energy Transmission Grating spectra of the stellar-mass black hole GRO J1655−40 during its 2005 outburst, revealing a rich and complex disk wind. Soon after its launch, the Neil Gehrels Swift Observatory began monitoring the same outburst. Some X-ray Telescope (XRT) observations were obtained in a mode that makes it impossible to remove strong Mn calibration lines, so the Fe Kα line region in the spectra was previously neglected. However, these lines enable a precise calibration of the energy scale, facilitating studies of the absorption-dominated disk wind and its velocity shifts. Here we present fits to 15 …

Arc‐Type Magmatism Due To Continental‐Edge Plowing Through Ancient Subduction‐Enriched Mantle, Douwe J.J. Van Hinsbergen, Wim Spakman, Hugo De Boorder, Michiel Van Dongen, Simon M. Jowitt, Paul R.D. Mason

Geoscience Faculty Research

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Alma 0.88 Mm Survey Of Disks Around Planetary-Mass Companions, Ya-Lin Wu, Brendan P. Bowler, Patrick D. Sheehan, Sean M. Andrews, Gregory J. Herczeg, Adam L. Kraus, Luca Ricci, David J. Wilner, Zhaohuan Zhu

Physics & Astronomy Faculty Research

Characterizing the physical properties and compositions of circumplanetary disks can provide important insights into the formation of giant planets and satellites. We report Atacama Large Millimeter/submillimeter Array 0.88 mm (Band 7) continuum observations of six planetary-mass (10–20 M Jup) companions: CT Cha b, 1RXS 1609 b, ROXs 12 b, ROXs 42B b, DH Tau b, and FU Tau b. No continuum sources are detected at the locations of the companions down to 3σ limits of 120–210 μJy. Given these nondetections, it is not clear whether disks around planetary-mass companions indeed follow the disk-flux–host-mass trend in the stellar regime. The faint …

Analysis Of Cryptotephra At Whitney Mesa Nature Preserve, Henderson, Nevada, Alex Newsom

Calvert Undergraduate Research Awards

Advanced Undergraduate Winner

Cryptotephra (small volcanic shards ranging 20-80 microns in size) were discovered within Unit X of the Las Vegas Formation at Whitney Mesa Nature Preserve, Henderson, Nevada. Cryptotephra are deposited soon after a volcanic eruption and can be used as a dating tool to create narrow time constraints for surrounding sediments. Cryptotephra have many applications but are mainly useful as a dating tool. Their study has important implications for the understanding of the timing of palaeoclimatological and paleoenvironmental events as well as for archaeological studies to date important events in human history.

The Whitney Mesa cryptotephra were correlated …

Insight On Thermal Stability Of Magnetite Magnetosomes: Implications For The Fossil Record And Biotechnology, Jefferson Cypriano, Mounib Bahri, Kassioge Dembele, Walid Baaziz, Pedro Leao, Dennis A. Bazylinski, Fernanda Abreu, Ovidiu Ersen, Marcos Farina, Jacques Werckmann

Life Sciences Faculty Research

Magnetosomes are intracellular magnetic nanocrystals composed of magnetite (Fe3O4) or greigite (Fe3S4), enveloped by a lipid bilayer membrane, produced by magnetotactic bacteria. Because of the stability of these structures in certain environments after cell death and lysis, magnetosome magnetite crystals contribute to the magnetization of sediments as well as providing a fossil record of ancient microbial ecosystems. The persistence or changes of the chemical and magnetic features of magnetosomes under certain conditions in different environments are important factors in biotechnology and paleomagnetism. Here we evaluated the thermal stability of magnetosomes in a temperature range between 150 and 500 °C subjected …

On-Chip Terahertz Modulation And Emission With Integrated Graphene Junctions, Joshua O. Island, Peter Kissin, Jacob Schalch, Xiaomeng Cui, Sheikh Rubaiat Ui Haque, Alex Potts, Takashi Taniguchi, Kanji Watanabe, Richard D. Averitt, Andrea F. Young

Physics & Astronomy Faculty Research

The efficient modulation and control of ultrafast signals on-chip is of central importance in terahertz (THz) communications and a promis- ing route toward sub-diffraction limit THz spectroscopy. Two-dimensional (2D) materials may provide a platform for these endeavors. We explore this potential, integrating high-quality graphene p–n junctions within two types of planar transmission line circuits to modulate and emit picosecond pulses. In a coplanar strip line geometry, we demonstrate the electrical modulation of THz signal transmission by 95%. In a Goubau waveguide geometry, we achieve complete gate-tunable control over THz emission from a photoexcited graphene junction. These studies inform the development …

Vibration Overtone Hyperpolarizability Measured For H2, Rachel M. Ellis, David P. Shelton

Physics & Astronomy Faculty Research

The second hyperpolarizability (γ) of the H2 molecule was measured by gas-phase electric field induced second harmonic generation at the frequencies of the one-photon resonance for the 3–0 Q(J) overtone transitions (v, J = 0, J → 3, J for J = 0, 1, 2, and 3). The magnitude of the resonant contribution to γ was measured with 2% accuracy using the previously determined non-resonant γ for calibration. Pressure broadening and frequency shift for the transitions were also measured. A theoretical expression for the resonant vibrational γ contribution in terms of transition polarizabilities is compared to the observations. The measured …

Structure-Strength Relations Of Distinct Mon Phases From First-Principles Calculations, Cheng Lu, Changfeng Chen

Physics & Astronomy Faculty Research

Molybdenum mononitrides (MoN) exhibit superior strength and hardness among the large class of transition-metal light-element compounds, but the underlying atomistic mechanisms for their outstanding mechanical properties and the variations of those properties among various MoN phases adopting different crystal structures remain largely unexplored and require further investigation. Here we report first-principles calculations that examine the stress-strain relations of these materials, and systematically compare results under pure and indentation shear deformations. In particular, we examine the distinct bonding structures and the associated mechanical properties in four different crystal phases of MoN that have been experimentally synthesized and stabilized under various physical …

Indentation-Strain Stiffening In Tungsten Nitrides: Mechanisms And Implications, Cheng Lu, Changfeng Chen

Physics & Astronomy Faculty Research

We report on a systematic computational study of ideal strengths, i.e., the lowest stresses needed to destabilize a perfect crystal under a variety of loading conditions for six stable and metastable tungsten nitrides identified by advanced crystal structure search algorithms. We employ first-principles calculations to determine stress-strain relations and examine the corresponding atomistic bonding changes for a microscopic understanding of the structural deformation modes. The obtained results show that, in stark contrast to many previously studied transition-metal borides, carbides, and also most nitrides, the tungsten nitrides exhibit surprisingly broad and common patterns of strain-stiffening effects under indentation strains. These extraordinary …

Global 3d Radiation Magnetohydrodynamic Simulations For Fu Ori's Accretion Disc And Observational Signatures Of Magnetic Fields, Zhaohuan Zhu, Yan-Fei Jiang, James M. Stone

Physics & Astronomy Faculty Research

FU Ori is the prototype of FU Orionis systems that are outbursting protoplanetary discs. Magnetic fields in FU Ori’s accretion discs have previously been detected using spectropolarimetry observations for Zeeman effects. We carry out global radiation ideal MHD simulations to study FU Ori’s inner accretion disc. We find that (1) when the disc is threaded by vertical magnetic fields, most accretion occurs in the magnetically dominated atmosphere at z ∼ R, similar to the ‘surface accretion’ mechanism in previous locally isothermal MHD simulations. (2) A moderate disc wind is launched in the vertical field simulations with a terminal speed of …

Superconductivity In Compression-Shear Deformed Diamond, Chang Liu, Xianqi Song, Quan Li, Yanming Ma, Changfeng Chen

Physics & Astronomy Faculty Research

Diamond is a prototypical ultrawide band gap semiconductor, but turns into a superconductor with a critical temperature Tc≈4 K near 3% boron doping [E. A. Ekimov et al., Nature (London) 428, 542 (2004)]. Here we unveil a surprising new route to superconductivity in undoped diamond by compression-shear deformation that induces increasing metallization and lattice softening with rising strain, producing phonon mediated Tc up to 2.4–12.4 K for a wide range of Coulomb pseudopotential μ∗=0.15–0.05. This finding raises intriguing prospects of generating robust superconductivity in strained diamond crystal, showcasing a distinct and hitherto little explored approach to driving materials into superconducting …

The Breakup Of A Helium Cluster After Removing Attractive Interaction Among A Significant Number Of Atoms In The Cluster, Tao Pang

Physics & Astronomy Faculty Research

The breakup of a quantum liquid droplet is examined through a 4He cluster by removing the attractive tail in the interaction between some of the atoms in the system with the diffusion quantum Monte Carlo simulation. The ground-state energy, kinetic energy, cluster size, and density profile of the cluster are evaluated against the percentage of the atoms without the attractive tail. The condition for the cluster to lose its ability to form a quantum liquid droplet at zero temperature is found and analyzed. The cluster is no longer able to form a quantum liquid droplet when about two-thirds of pairs …

Techno-Economic Analysis Of Electrocoagulation On Water Reclamation And Bacterial/Viral Indicator Reductions Of A High-Strength Organic Wastewater—Anaerobic Digestion Effluent, Sibel Uludag-Demirer, Nathan Olson, Rebecca Ives, Jean Pierre Nshimyimana, Cory A. Rusinek, Joan B. Rose, Wei Liao

Chemistry and Biochemistry Faculty Research

This study investigated the use of iron and aluminum and their combinations as electrodes to determine the technically sound and economically feasible electrochemical approach for the treatment of anaerobic digestion effluent. The results indicated that the use of iron as anode and cathode is the most suitable solution among different electrode combinations. The reduction of turbidity, total chemical oxygen demand, total phosphorus, total coliforms, Escherichia coli, Enterococci, and phages in the reclaimed water were 99%, 91%, 100%, 1.5 log, 1.7 log, 1.0 log, and 2.0 log, respectively. The economic assessment further concluded that the average treatment cost is $3 per …

Correlation Coefficients For A Study With Repeated Measures, Guogen Shan, Hua Zhang, Tao Jiang

Environmental & Occupational Health Faculty Publications

Repeated measures are increasingly collected in a study to investigate the trajectory of measures over time. One of the first research questions is to determine the correlation between two measures. The following five methods for correlation calculation are compared: (1) Pearson correlation; (2) correlation of subject means; (3) partial correlation for subject effect; (4) partial correlation for visit effect; and (5) a mixed model approach. Pearson correlation coefficient is traditionally used in a cross-sectional study. Pearson correlation is close to the correlations computed from mixed-effects models that consider the correlation structure, but Pearson correlation may not be theoretically appropriate in …

Fast Radio Bursts As Strong Waves Interacting With The Ambient Medium, Yuan-Pei Yang, Bing Zhang

Physics & Astronomy Faculty Research

Fast radio bursts (FRBs) are mysterious radio transients whose physical origin is still unknown. Within a few astronomical units near an FRB source, the electric field of the electromagnetic wave is so large that the electron oscillation velocity becomes relativistic, which makes the classical Thomson scattering theory and the linear plasma theory invalid. We discuss FRBs as strong waves interacting with the ambient medium, in terms of both electron motion properties and plasma properties. Several novel features are identified. (1) The cross section of Thomson scattering is significantly enhanced for the scattering photons. (2) On the other hand, because of …

On The Frb Luminosity Function – – Ii. Event Rate Density, Rui Luo, Yunpeng Men, Kejia Lee, Weiyang Wang, D. R. Lorimer, Bing Zhang

Physics & Astronomy Faculty Research

The luminosity function of Fast Radio Bursts (FRBs), defined as the event rate per unit cosmic co-moving volume per unit luminosity, may help to reveal the possible origins of FRBs and design the optimal searching strategy. With the Bayesian modelling, we measure the FRB luminosity function using 46 known FRBs. Our Bayesian framework self-consistently models the selection effects, including the survey sensitivity, the telescope beam response, and the electron distributions from Milky Way/ the host galaxy/ local environment of FRBs. Different from the previous companion paper, we pay attention to the FRB event rate density and model the event counts …

Testing The Hypothesis Of Compact-Binary-Coalescence Origin Of Fast Radio Bursts Using A Multimessenger Approach, Min-Hao Wang, Shun-Ke Ai, Zheng-Xiang Li, Nan Xing, He Gao, Bing Zhang

Physics & Astronomy Faculty Research

In the literature, compact binary coalescences (CBCs) have been proposed as one of the main scenarios to explain the origin of some non-repeating fast radio bursts (FRBs). The large discrepancy between the FRB and CBC event rate densities suggests that their associations, if any, should only apply at most for a small fraction of FRBs. Through a Bayesian estimation method, we show how a statistical analysis of the coincident associations of FRBs with CBC gravitational wave (GW) events may test the hypothesis of these associations. We show that during the operation period of the advanced Laser Interferometer Gravitational-Wave Observatory (aLIGO), …

High Dielectric Ternary Oxides From Crystal Structure Prediction And High-Throughput Screening, Jingyu Qu, David Zagaceta, Weiwei Zhang, Qiang Zhu

Physics & Astronomy Faculty Research

The development of new high dielectric materials is essential for advancement in modern electronics. Oxides are generally regarded as the most promising class of high dielectric materials for industrial applications as they possess both high dielectric constants and large band gaps. Most previous researches on high dielectrics were limited to already known materials. In this study, we conducted an extensive search for high dielectrics over a set of ternary oxides by combining crystal structure prediction and density functional perturbation theory calculations. From this search, we adopted multiple stage screening to identify 441 new low-energy high dielectric materials. Among these materials, …

Thermal Analysis, Compressibility, And Decomposition Of Synthetic Bastnäsite-(La) To Lanthanum Oxyfluoride, Richard L. Rowland, Barbara Lavina, Kathleen E. Vander Kadeen, Lisa R. Danielson, Pamela C. Burnely

Geoscience Faculty Research

Understanding basic material properties of rare earth element (REE) bearing minerals such as their phase stability and equations of state can assist in understanding how economically viable deposits might form. Bastnäsite is the most commonly mined REE bearing mineral. We synthesized the lanthanum-fluoride end member, bastnäsite-(La) (LaCO3F), and investigated its thermal behavior and decomposition products from 298 K to 1173 K under ambient pressure conditions through thermogravimetric analysis, differential scanning calorimetry, evolved gas analysis, and high temperature powder X-ray diffraction. We also investigated the compressibility of bastnäsite-(La) via single crystal X-ray diffraction in diamond anvil cells at an ambient temperature …

Fast Radio Bursts From Interacting Binary Neutron Star Systems, Bing Zhang

Physics & Astronomy Faculty Research

Recent observations of repeating fast radio bursts (FRBs) suggest that some FRBs reside in an environment consistent with that of binary neutron star (BNS) mergers. The bursting rate for repeaters could be very high and the emission site is likely from a magnetosphere. We discuss a hypothesis of producing abundant repeating FRBs in BNS systems. Decades to centuries before a BNS system coalesces, the magnetospheres of the two neutron stars start to interact relentlessly. Abrupt magnetic reconnection accelerates particles, which emit coherent radio waves in bunches via curvature radiation. FRBs are detected as these bright radiation beams point toward Earth. …

Teaching A University Course On The Mathematics Of Gambling, Stewart N. Ethier, Fred M. Hoppe

UNLV Gaming Research & Review Journal

Courses on the mathematics of gambling have been offered by a number of colleges and universities, and for a number of reasons. In the past 15 years, at least seven potential textbooks for such a course have been published. In this article we objectively compare these books for their probability content, their gambling content, and their mathematical level, to see which ones might be most suitable, depending on student interests and abilities. This is not a book review (e.g., none of the books is recommended over others) but rather an essay offering advice about which topics to include in a …