Physical Sciences and Mathematics Commons^™

From Florida To Antarctica: Dereplication Strategies And Chemical Investigations Of Marine Organisms, Matthew A. Knestrick

USF Tampa Graduate Theses and Dissertations

In the fight against disease and illness, nature has provided mankind some of our best therapeutics in the form of secondary metabolites. The plant, fungi and animal phyla inhabiting the Earth produce diverse and unique chemistry that can be used in our fight against disease. In the growing threat of drug resistance and pathogen evolution, the field of natural products chemistry strives to explore new biological and chemical diversity sources, and develop innovative methodology to identify and isolate new chemistry faster than ever.

The dissertation herein presented is one such effort to find new, bioactive chemistry from the marine environments. …

Evaluation Of Academic And Social Engagement In A Technology-Based Collaborative Approach To Inclusive Geoscience Field Learning, Anita Marie Stone Marshall

USF Tampa Graduate Theses and Dissertations

Field learning is an important aspect of geoscience education to teach or reinforce concepts and skills, and the highly social experience of field work can improve learning outcomes, create networks to support future academic success, and promote a sense of belonging in the geosciences. However, field learning presents significant barriers to participation for students with physical disabilities. The introduction of digital data collection and communication devices into traditional field work settings has created new opportunities to expand access to field learning experiences such as remote collaboration; a method of undertaking field work through collaborative teamwork and the use of digital …

Azamacrocyclic-Based Frameworks: Syntheses And Characterizations, Chavis Andrew Stackhouse

USF Tampa Graduate Theses and Dissertations

Research in metal-organic frameworks (MOFs) has risen greatly in recent decades Owing to their unequaled potential tunability and structural diversity. MOFs may be described as crystalline structures composed of metal cations or clusters of cations, commonly referred to as secondary building units (SBUs), and custom-designed organic ligands. The variety of structural motifs, ligands, and SBUs that may be incorporated promote the attainment of essentially countless potential MOFs and application in numerous areas of interest, such as gas adsorption, catalysis, gas separation, and sensing. Further functionalization of MOF materials by means of post-synthetic modification(PSM)33–37 of metal clusters or organic ligands, constructing …

Identification Of Individuals From Ears In Real World Conditions, Earnest Eugene Hansley

USF Tampa Graduate Theses and Dissertations

A number of researchers have shown that ear recognition is a viable alternative to more common biometrics such as fingerprint, face and iris because the ear is relatively stable over time, the ear is non-invasive to capture, the ear is expressionless, and both the ear’s geometry and shape have significant variation among individuals. Researchers have used different approaches to enhance ear recognition. Some researchers have improved upon existing algorithms, some have developed algorithms from scratch to assist with recognizing individuals by ears, and some researchers have taken algorithms tried and tested for another purpose, i.e., face recognition, and applied them …

Characterization Of Nylon-12 In A Novel Additive Manufacturing Technology, And The Rheological And Spectroscopic Analysis Of Peg-Starch Matrix Interactions, Garrett Michael Craft

USF Tampa Graduate Theses and Dissertations

In this work differential scanning calorimetry, dynamic mechanical analysis, Fourier-Transformed Infrared Spectroscopy [FT-IR] and polarized light microscopy will be employed to characterize polymeric systems. The first chapter broadly covers polymer synthesis and important characterization methods.

In the second chapter, a polyamide (PA12) will be sintered via a novel additive manufacturing (AM) technology developed here at USF termed LAPS (Large Area Projection Sintering). LAPS uses extended sintering timespans to ensure complete melting and densification of the polymer powder over the entire two-dimensional area of the part’s footprint. Further, it allows for the printed layer to crystallize and shrink in its entirety …

Characterization Of Computed Tomography Radiomic Features Using Texture Phantoms, Muhammad Shafiq Ul Hassan

USF Tampa Graduate Theses and Dissertations

Radiomics treats images as quantitative data and promises to improve cancer prediction in radiology and therapy response assessment in radiation oncology. However, there are a number of fundamental problems that need to be solved in order to potentially apply radiomic features in clinic. The first basic step in computed tomography (CT) radiomic analysis is the acquisition of images using selectable image acquisition and reconstruction parameters. Radiomic features have shown large variability due to variation of these parameters. Therefore, it is important to develop methods to address these variability issues in radiomic features due to each CT parameter. To this end, …

Elastin-Like Polypeptide Fusion Tag As A Protein-Dependent Solubility Enhancer Of Cysteine-Knot Growth Factors, Tamina L. Johnson

USF Tampa Graduate Theses and Dissertations

Elastin-like peptide (ELP) fusions promote therapeutic delivery and efficacy. Recombinant proteins, like neurotrophins, lack bioavailability, have short in vivo half-lives, and require high manufacturing costs. Fusing recombinant proteins with genetically encodable ELPs will increase bioavailability, enhance in vivo solubilization, as well as provide a cost-effective method for purification without the need for chromatography. During expression of neurotrophin-ELP (N-ELP) fusions, dense water-insoluble aggregates known as inclusion bodies (IBs) are formed. Inclusion bodies are partially and misfolded proteins that usually require denaturants like Urea for solubilization. Strong denaturants arrest ELPs stimuli-responsive property and increase unwanted aggregation, making purification difficult, yet possible. The …

Coarse-Grained Modeling Studies Of Polymeric And Granular Systems, Hong Trung Nguyen

USF Tampa Graduate Theses and Dissertations

This Dissertation is devoted to computational study of the solidification, dynamics and mechanics of model semiflexible polymers with variable chain flexibility as well as a computational investigation of the clogging phenomena observed in granular materials.

Chain stiffness is an intrinsic factor that governs single-chain flexibility. It plays a critical role in the physics of polymeric materials. In this work, we employ a coarse-grained polymer model in which chain stiffness can be tuned by a single parameter (bending stiffness kb) that yields chain shape ranging from coil-like to rod-like in the flexible and very stiff limit respectively. In chapter 2, we …

Computational Discovery Of Energetic Polynitrogen Compounds At High Pressure, Brad A. Steele

USF Tampa Graduate Theses and Dissertations

High-nitrogen-content energetic compounds containing multiple N-N bonds are an attractive alternative towards developing new generation of environmentally friendly, and more powerful energetic materials. High-N content translates into much higher heat of formation resulting in much larger energy output, detonation pressure and velocity upon conversion to large amounts of non-toxic, strongly bonded N2 gas. This thesis describes recent advances in the computational discovery of group-I alkali and hydrogen polynitrogen materials at high pressures using powerful first-principles evolutionary crystal structure prediction methods. This is highlighted by the discovery of a new family of materials that consist of long-sought after all-nitrogen N􀀀 5 …

Flow And Transport In Low-Gradient Rivers And Estuaries, Hunter Lee Clasen

USF Tampa Graduate Theses and Dissertations

For this dissertation I studied flow and transport in low gradient Florida streams. Chapter 2 is a statewide analysis of long-term variations in stream discharge. The results from Chapter 2 suggest that changes in mean annual stream discharge are controlled by the Atlantic Multi-Decadal Oscillation (AMO). During the warm phase, mean annual discharge decreases in central Florida and increases in north Florida. The opposite is true during the cool phase, with mean annual discharge increasing in central Florida and decreasing in north Florida. This pattern is observed for both components of stream discharge, base flow and runoff.

The following two …

Synthesis Of Novel Agents For The Treatment Of Infectious And Neurodegenerative Diseases, Benjamin Joe Eduful

USF Tampa Graduate Theses and Dissertations

Infectious and neurodegenerative diseases continue to be a major concern worldwide. In spite of the great advances in drug therapy for treating various infectious and neurodegenerative diseases, there is still an urgent need for new and improved drugs due to increasing drug resistance among pathogens, emergence of new pathogens, ease of transmission of infections, ineffective available treatments, toxicity associated with current standard of care, aging populations and the lack of better alternative treatment options.

The first part of this manuscript (chapters 1 - 5) describes the synthesis of novel agents active against Leishmania donovani. According to the World Health Organization …

Investigating The Origin Of Continual Radio Frequency Impulses During Explosive Volcanic Eruptions, S. A. Behnke, H. E. Edens, R. J. Thomas, C. M. Smith, Stephen R. Mcnutt, A. R. Van Eaton, C. Cimarelli, V. Cigala

School of Geosciences Faculty and Staff Publications

Volcanic lightning studies have revealed that there is a relatively long‐lasting source of very high frequency radiation associated with the onset of explosive volcanic eruptions that is distinct from radiation produced by lightning. This very high frequency signal is referred to as “continual radio frequency (CRF)” due to its long‐lasting nature. The discharge mechanism producing this signal was previously hypothesized to be caused by numerous, small (10–100 m) leader‐forming discharges near the vent of the volcano. To test this hypothesis, a multiparametric data set of electrical and volcanic activity occurring during explosive eruptions of Sakurajima Volcano in Japan was collected …

The Concept Of Water Storage On Agriculture Lands: Exploring The Notion In South Florida, Kayla Ouellette, Kamal Alsharif, John C. Capece, Hannah Torres

School of Geosciences Faculty and Staff Publications

Lands in the Everglades Agricultural Area (EAA) can be used for increased water storage in order to relieve coastal estuaries of excess runoff in the rainy season. The goals of this study were: (1) to quantify the environmental and economic tradeoffs of different water storage scenarios using water tolerant sugarcane cultivars; and (2) to quantify the amount of water storage possible in the EAA under different water storage scenarios. A mathematical model was developed to calculate soil depth, soil subsidence, depth to the water table, and water storage for three different sugarcane cultivars with different water tolerances. The …

Grounding Line Migration Through The Calving Season At Jakobshavn Isbræ, Greenland, Observed With Terrestrial Radar Interferometry, Surui Xie, Timothy H. Dixon, Denis Voytenko, Fanghui Deng, David M. Holland

School of Geosciences Faculty and Staff Publications

Ice velocity variations near the terminus of Jakobshavn Isbræ, Greenland, were observed with a terrestrial radar interferometer (TRI) during three summer campaigns in 2012, 2015, and 2016. We estimate a  ∼ 1km wide floating zone near the calving front in early summer of 2015 and 2016, where ice moves in phase with ocean tides. Digital elevation models (DEMs) generated by the TRI show that the glacier front here was much thinner (within 1km of the glacier front, average ice surface is  ∼ 100 and  ∼ 110m above local sea level in 2015 and 2016, respectively) than ice upstream (average ice …

Bridging The Under-Five Mortality Gap For Africa In The Era Of Sustainable Development Goals: An Ordinary Least Squares (Ols) Analysis, Michael Acheampong, Chukwudi Ejiofor, Abraham A. Salinas-Miranda, Foday M. Jaward, Michael K. Eduful, Qiuyan Yu

School of Geosciences Faculty and Staff Publications

Background: While Africa achieved significant progress in reducing under-five mortality rate (U5MR) in the MDGs era, it did not achieve the set target and still has the highest average of 81 deaths per 1000 live births compared to a global average of 43 deaths. The SDG number 3 has set a new target of reducing U5MR to 25 deaths per 1000 births in the world, which serves a huge challenge, especially for Africa. Socioeconomic inequities that remain unaddressed across countries account for Africa’s high U5MR. Unless there is adequate prioritization of important socioeconomic, healthcare, and environmental factors, the new SDGs …

Climate Change: Aristotelian Virtue Theory, The Aidōs Response And Proper Primility, John W. Voelpel

USF Tampa Graduate Theses and Dissertations

Climate change is the first anthropogenic alteration of a global Earth system. It is globally catastrophic in terms of food production, sea level rise, fresh water availability, temperature elevation, ocean acidification, species disturbance and destruction to name just a few crisis concerns. In addition, while those changes are occurring now, they are amplifying over decadal periods and will last for centuries and possibly millennia. While there are a number of pollutants involved, carbon dioxide (CO2) which results from the combustion of any fossil fuel is the primary pollutant. It has not been considered a pollutant until recently because of its …

A Fall Prevention System For The Elderly And Visually Impaired, Yueng Santiago De La Hoz Isaza

USF Tampa Graduate Theses and Dissertations

The World Health Organization claims that there are more than 285 million blind and visually impaired people in the world. In the US, 25 million Americans suffer from total or partial vision loss. As a result of their impairment, they struggle with mobility problems, especially the risk of falling. According to the National Council On Aging, falls are among the primary causes for fatal injury and they are the most common cause of non-fatal trauma-related hospital admissions among older adults. Visibility, an organization that helps visually impaired people, reports that people with visual impairments are twice as likely to fall …

In Situ Extrinsic Doping Of Cdte Thin Films For Photovoltaic Applications, Imran Suhrid Khan

USF Tampa Graduate Theses and Dissertations

The Cadmium Telluride thin film solar cell is one of the leading photovoltaic technologies. Efficiency improvements in the past decade made it a very attractive and practical source of renewable energy. Considering the theoretical limit, there is still room for improvement, especially the cell’s open circuit voltage (VOC). To improve VOC, the p-type carrier concentration and minority carrier lifetime of the CdTe absorber needs to be improved. Both these parameters are directly related to the point defect distribution of the semiconductor, which is a function of deposition stoichiometry, dopant incorporation and post-deposition treatments.

CdTe films were deposited by the Elemental …

Dynamic Energy-Aware Database Storage And Operations, Peyman Behzadnia

USF Tampa Graduate Theses and Dissertations

Energy consumption has become a first-class optimization goal in design and implementation of data-intensive computing systems. This is particularly true in the design of database management systems (DBMS), which is one of the most important servers in software stack of modern data centers. Data storage system is one of the essential components of database and has been under many research efforts aiming at reducing its energy consumption. In previous work, dynamic power management (DPM) techniques that make real-time decisions to transition the disks to low-power modes are normally used to save energy in storage systems. In this research, we tackle …

Signal Detection Of Adverse Drug Reaction Using The Adverse Event Reporting System: Literature Review And Novel Methods, Minh H. Pham

USF Tampa Graduate Theses and Dissertations

One of the objectives of the U.S. Food and Drug Administration is to protect the public health through post-marketing drug safety surveillance, also known as Pharmacovigilance. An inexpensive and efficient method to inspect post-marketing drug safety is to use data mining algorithms on electronic health records to discover associations between drugs and adverse events.

The purpose of this study is two-fold. First, we review the methods and algorithms proposed in the literature for identifying association drug interactions to an adverse event and discuss their advantages and drawbacks. Second, we attempt to adapt some novel methods that have been used in …

Application Of Modern Foraminiferal Assemblages To Paleoenvironmental Reconstruction: Case Studies From Coastal And Shelf Environments, Christian Haller

USF Tampa Graduate Theses and Dissertations

The aim of paleoenvironmental studies is to reconstruct characteristics of the past environment from fossil assemblages preserved in sedimentary strata. Thus, studies of modern surface assemblages, quantitatively correlated to the environmental parameters, are required before reliable interpretations can be made. For this dissertation, two different techniques were applied in two case studies: a reconstruction making use of a benthic foraminiferal transfer function from the intertidal marshes in the eastern Mississippi Sound, Alabama/Mississippi, and a qualitative reconstruction of ocean current activity on the Western Australian shelf.

Modern salt-marsh foraminifera were collected from Grand Bay, Pascagoula, Fowl River, and Dauphin Island across …

Synthesis, Modification, Characterization And Processing Of Molded And Electrospun Thermoplastic Polymer Composites And Nanocomposites, Tamalia Julien

USF Tampa Graduate Theses and Dissertations

This dissertation focuses on the versatility and integrity of a novel, ultrasoft polycarbonate polyurethane (PCPU) by the introduction of nanoparticles and lithium salts. Additionally, the research takes into account the use of electrospinning as a technique to create PCPU and polyimide (PI) fibers. These polymers are of interest as they offer a wide range of properties and uses within the medical and industrial fields.

An industrial batch of an ultrasoft thermoplastic polyurethane (TPU) was synthesized using a two-step process. The first was to create an end capped pre-polymer from methylene bis (4-cyclohexylisocyanate), and a polycarbonate polyol made up of 1,6- …

Remote Sensing And Spatial Metrics For Quantifying Seagrass Landscape Changes: A Study On The 2011 Indian River Lagoon Florida Seagrass Die-Off Event, René Dieter Baumstark

USF Tampa Graduate Theses and Dissertations

Florida’s seagrasses are ecologically important marine environments which have suffered major degradation caused by increasing anthropogenic pressures. A 2011 seagrass die-off event caused by an algal bloom in the Florida Indian River Lagoon (IRL) was particularly severe with a majority of seagrass lost in areas such as the Banana River. An understanding of how this coastal marine environment changed is an important step toward better managing resources for conservation. Modern tools and methods provide new opportunities to study these changes at the landscape scale, a scale that informs on the larger more comprehensive state of a system. Classified satellite imagery …

Rain Rituals As A Barometer Of Vulnerability In An Uncertain Climate, L. Jen Shaffer

Journal of Ecological Anthropology

Researchers and aid agencies, seeking to improve their understanding of local climate change responses, adaptation, and vulnerability, frequently interact with communities around the world who strongly emphasize their religious beliefs and practices. Dismissal and misunderstandings of these local perspectives can slow assessments of local climate vulnerability and development of adaptive capacity. In this paper, I show how analysis of rain ritual failure exposes the multiple stressors Ronga communities in southern Mozambique face, and as such, serves as a proxy measure for climate vulnerability at the local level. Oral histories and targeted interviews with participating elders, local chiefs, and community members …

Geochemical Modeling Of Primary Morb Magmas: Implications For Parental Melting Regimes In Melt Lenses Along-Axis Of The Hess Deep Rift, Stephanie Michelle Drumm

USF Tampa Graduate Theses and Dissertations

The Hess Deep Rift in the East Pacific Rise is a mid-ocean ridge spreading center that produces melts which exhibit geochemical characteristics of evolved MORB. Using basaltic glass samples collected from multiple dive cruises that explored Hess Deep geology, volatile and chemical data were collected at USF using FTIR and EMPA, respectively. In addition, a data suite of samples of glass from Hess Deep were compiled from the EarthChem database. The intention was to use the data suite and models to compare the Hess Deep regime to analog models for mid-ocean ridge crystallization regimes and tectonic structures. The USF and …

The Stability Of Sand Waves In A Tidally-Influenced Shipping Channel, Tampa Bay, Florida, John Willis Gray

USF Tampa Graduate Theses and Dissertations

Tidally-influenced sandwaves are common coastal features present in various settings, including shipping channels. The main shipping channel in Tampa Bay under the Bob Graham Sunshine Skyway Bridge (a.k.a. the Skyway Bridge) contains such sandwave bedforms. Between the years 2000 and 2017, these bedforms have been surveyed with multibeam echosounders (MBES) on 21 occasions with ranging coverage and quality of returns. Surveys between 2000 and 2009 used a 300 kHz Kongsberg EM3000; surveys between 2015 and 2017 used a 400 kHz Reson Seabat 7125. For comparable surveys, bathymetry, backscatter, slope, curvature, planform curvature, and profile curvature maps were created and analyzed. …

Assessment Of Drinking Water Quality Management And A Treatment Feasibility Study For Brick By Brick Water Storage Tanks In Rakai Uganda, James V. Murduca

USF Tampa Graduate Theses and Dissertations

Reliable access to safe drinking water is one necessity for humans to live without concern for major health risks. The overall goal of this research is to improve the public health, through improved drinking water, for communities in the Rakai District in Uganda, directly, and other communities in the world, indirectly, via dissemination of knowledge. This study specifically assessed the knowledge of drinking water quality in regards to public health, their sanitation measures, and water treatment methods for users of Brick by Brick rainwater harvesting tanks in the Rakai District (N = 28) by using a knowledge, attitudes, and practice …

Reduction In Needlestick Injuries Using A Novel Package Of Interventions, Kamal Thakor Patel

USF Tampa Graduate Theses and Dissertations

In 2015 Dr. Pratiksha Vaghela started the “Stop Poking Me” campaign which was aimed at curbing the increase in the number of needlesticks at the James A. Haley Veteran Affairs Hospital (JAHVA). The data for needlesticks was collected by the Occupational Medicine Clinic (OMC) between Oct 2013 and Oct 2016. We then obtained the original data from Dr. Vaghela’s project and compared the data to assess whether the new implementations have truly decreased the number of needlesticks. There was a 23.6% reduction in the number of needlesticks between 2013 and 2016 and even more importantly a 60.1% reduction between 2015 …

Improving The Security Of Building Automation Systems Through An Sel4-Based Communication Framework, Richard Habeeb

USF Tampa Graduate Theses and Dissertations

Existing Building Automation Systems (BASs) and Building Automation Networks (BANs) have been shown to have serious cybersecurity problems. Due to the safety-critical and interconnected nature of building subsystems, local and network access control needs to be finer grained, taking into consideration the varying criticality of applications running on heterogeneous devices. In this paper, we present a secure communication framework for BASs that 1) enforces rich access control policy for operating system services and objects, leveraging a microkernel-based architecture; 2) supports fine-grained network access control on a per-process basis; 3) unifies the security control of inter-device and intra-device communication using proxy …

Design, Synthesis, Application Of Biodegradable Polymers, Mussie Gide

USF Tampa Graduate Theses and Dissertations

Bacterial infections have posed a serious threat to the public health due to the significant rise of the infections caused by antibiotic-resistant bacteria. There has been considerable interest in the development of antimicrobial agents which mimic the natural HDPs, and among them biodegradable polymers are newly discovered drug candidates with ease of synthesis and low manufacture cost compared to synthetic host defense peptides. Herein, we present the synthesis of biocompatible and biodegradable polymers including polycarbonate polymers, unimolecular micelle hyperbranched polymers and dendrimers that mimic the antibacterial mechanism of HDPs by compromising bacterial cell membranes. The developed amphiphilic polycarbonates are highly …