Physical Sciences and Mathematics Commons^™

Antioxidant Intervention In Radical-Induced Protein Damage, Emmanuel Zubia

Open Access Theses & Dissertations

Many environmental toxicants are known to increase free-radical production, which can create cellular havoc and lead to a myriad of ailments. Antioxidants can be used to ameliorate the prevalence of free radicals, potentially serving as prophylactics against radical-induced disorders. Many exogenous antioxidants are phytochemicals in origin, such as ascorbic acid, gallic acid, and ellagic acid. Some of these antioxidants can be found in traditional medicine, like tanshinone and brazilin, which have been studied and are known to have low cytotoxicity. Here we test the radical rescue capacity of a selected group of phytochemical antioxidants on protein rescue models. Specifically, our …

Development And Assesment Of Local Scaled Self-Interaction Corrected Density Functional Method With Simple Scaling Factor, Selim Romero

Open Access Theses & Dissertations

The Hohenberg-Kohn-Sham (HKS) density functional theory (DFT) is widely used to compute electronic structures of atoms, molecules, and solids. It is an exact theory in which ground state electron density plays the role of basic variable, same as the wavefunction does in quantum mechanics. The total ground state energy is a functional of electron density. The practical application of HKS DFT require approximation to the exchange-correlation energy functional. Many density functional approximations (DFAs) with various degree of sophistication and complexities have been developed. Depending on the complexity, these functionals include electron density, density gradients, density Laplacian, kinetic energy densities, Hartree-Fock …

Self-Similar Models: How Close The Diffusion Entropy Analysis And The Detrended Fluctuation Analysis Are From Other Models, William Kubin

Open Access Theses & Dissertations

Financial and seismic data, like many other high frequency data are known to exhibit memory effects. In this research, we apply the concepts of L ́evy processes, Diffusion Entropy Analysis (DEA) and the Detrended Fluctuation Analysis (DFA) to examine long-range persistence (long memory) behavior in time series data. L ́evy processes describe long memory effects. In other words, L ́evy process (where the increments are independent and follow the L ́evy distribution) is self-similar. We examine the relationship between the L ́evy parameter (α) characterizing the data and the scaling exponent of DEA (δ) and that of DFA (H) characterizing …

Supra-Salt Syndepositional Folding Within The Jurassic Morrison Formation, Big Gypsum Valley, Colorado, Alondra Soltero

Open Access Theses & Dissertations

The Paradox Basin, along the Utah and Colorado border, exposes salt diapirs that form elongate "salt walls". Most exposures of sediments that were deposited during salt movement are hundreds of meters from the contacts. However, in the southeastern part of the Gypsum Valley diapir, a set of tight folds within the Jurassic Morrison Formation are preserved along the diapir margins where they overlie salt. These are best exposed at the southeastern end of Big Gypsum Valley. Previous interpretations suggested that the Morrison Formation folding and faulting occurred during dissolution of the diapir. However, field mapping reported here reveals that the …

Spectroscopic Techniques To Characterize And Develop Sensing Methods For Titanium Dioxide Nanoparticles In Water, Reagan Scott Turley

Open Access Theses & Dissertations

Titanium dioxide nanoparticles are being used in ever increasing amounts and applications in many consumer products and industrial processes including water treatment. These nanoparticles have not been shown to be toxic to humans via ingestion, but it is worthwhile to develop a portable and rapid detection method to quantify the concentration of nanoparticles in treated drinking water. Current detection methods include single particle inductively coupled plasma mass spectrometry, inductively coupled plasma optical emission spectrometry, tunneling electron microscopy and scanning electron microscopy. While extremely sensitive, these techniques are expensive and sometimes require extensive sample preparation before analysis. A preliminary study on …

Partitioning Variation In Vegetation And Landscape Functionality In Arid Land Piosphere, Eahsan Shahriary

Open Access Theses & Dissertations

A piosphere is an interaction between vegetation community, watering point, and grazing livestock/wildlife. In this Dissertation, I begin by reviewing the concept of the piosphere, and the progress, knowledge gaps and common statistical approaches and errors in piosphere research. Landscape functionality, plant community distribution and their influencing factors on a piosphere in Iran are then investigated.

A total 862 piosphere publications of multiple types from 68 countries and 10 different languages during the period of 1915 â?? 2018 were reviewed. Australia was the most productive country followed by South Africa, the USA, Botswana and Argentina. Ivan Thrash is the most …

Laplacian Spectra Of Kneser-Like Bipartite Graphs, Cesar Iram Vazquez

Open Access Theses & Dissertations

Given a,b ∈N such that a > b we define a Kneser-like bipartite graph G(a,b), whose two bipartite sets of vertices represent the a-subsets and b-subsets of S = {1,...,a + b + 1}, and whose edges are pairs of vertices X and Y such that X ∩Y = ∅. We prove that the eigenvalues of the Laplacian matrix of graphs G(a,1) are all nonnegative integers. In fact, we describe these eigenvalues, and their respective multiplicities.

Expression, Purification, And Characterization Of Recombinant Human Npas2, Brenda Moreno

Open Access Theses & Dissertations

Many living organisms have biological clocks known as circadian rhythms that control various physiological and behavioral processes, tailored with the day and night. At the cellular level, the circadian clock drives daily rhythms with a transcriptional-translational feedback loop (TTFL) established by multiple transcription factors and genes under their regulation. Circadian Locomotor Output Cycles Kaput (CLOCK) and Brain and Muscle ARNT-like protein 1 (BMAL1) are two of those transcription factors, initiating the TTFL by forming a heterodimeric complex that bind to DNA promoters. Neuronal PAS domain protein 2 (NPAS2) is a functional analog to CLOCK. Less knowledge about NPAS2, in contrast …

A Comprehensive And Modular Robotic Control Framework For Model-Less Control Law Development Using Reinforcement Learning For Soft Robotics, Charles Sullivan

Open Access Theses & Dissertations

Soft robotics is a growing field in robotics research. Heavily inspired by biological systems, these robots are made of softer, non-linear, materials such as elastomers and are actuated using several novel methods, from fluidic actuation channels to shape changing materials such as electro-active polymers. Highly non-linear materials make modeling difficult, and sensors are still an area of active research. These issues have rendered typical control and modeling techniques often inadequate for soft robotics. Reinforcement learning is a branch of machine learning that focuses on model-less control by mapping states to actions that maximize a specific reward signal. Reinforcement learning has …

Spatially Adaptive Estimation Of Spectrum, Yi None Xie

Open Access Theses & Dissertations

When analyzing a stationary time series, one of the questions we are often interested in is how to estimate its spectrum. Many approaches have been proposed to this end. Most are focused on smoothing the periodogram using a single smoothing parameter across all Fourier frequencies. In this paper, we smooth the log periodogram by placing a spatially adaptive prior called the dynamic shrinkage prior, so that varying degrees of smoothing may be applied to different intervals of Fourier frequencies, resulting in less biased estimates of the spectrum. Further research will extend this approach to spectral estimation for nonstationary time series.

Understanding The Digital Lives Of Transnational Students: A Case Study, Chowaing Chagra Belekeh

Open Access Theses & Dissertations

The proliferation and the fast-paced evolution of digital information communication technologies (ICTs) in contemporary times have arguably raised concern for us to comprehend what we do with these technologies and what these technologies do for us. The experience of engaging these technologies may not necessarily be the same for everyone—especially students who come from around the world to attain post-graduate degrees in the United States. This research focused on understanding the digital lives, choices, and experiences of transnational students who navigate and negotiate geopolitical borders and boundaries (physical)– in their quest for education. Using a case study analysis and collecting …

Applications Of Ornstein-Uhlenbeck Type Stochastic Differential Equations, Osei Kofi Tweneboah

Open Access Theses & Dissertations

In this Dissertation, we show with plausible arguments that the Stochastic Differential Equations (SDEs) arising on the superposition and coupling system of independent Ornstein-Uhlenbeck process is a new method available in modern literature that takes the properties and behavior of the data into consideration when performing the statistical analysis of the time series.

The time series to be analyzed is thought of as a source of fluctuations, and thus we need a model that takes this behavior into consideration when performing such analysis. Most of the standard methods fail to take into account the physical behavior of the time series, …

Finalcache: Eviction Based On Implicit Entry Reachability, Adrian Veliz

Open Access Theses & Dissertations

Software caches for garbage collected systems are unaware which cache entries are referenced by a client program. Lacking this key information, software caches cannot determine the cache’s contribution to the program’s memory footprint. Furthermore, their eviction heuristics must rely on access history as a proxy for usage. Divergence between usage and access history can undermine the intention of eviction thereby resulting in problematic cache behavior.

This dissertation proposes designs for a novel family of “usage-based” software cache informed of entry reachability by the automatic memory management system. Unlike extant software caches, usage-based caches can accurately determine their memory footprint because …

Life Cycle Studies To Evaluate The Physiological And Biochemical Effects Of Copper Oxide And Surface-Coated Titanium Dioxide Nanoparticles On Green Onion (Allium Fistulosum) And Carrot (Daucus Carota L.) Plants: Insights Utilizing Two-Photon Microscopy And Spectroscopy, Yi Wang

Open Access Theses & Dissertations

With the recent increase of nanomaterial production, nano copper oxide (nCuO) and surface-modified titanium dioxide nanoparticles (nTiO2) are among the most widely applied nanoparticles in industry and daily lives. Their use has resulted in accumulation in soils as a consequence of their direct or indirect release. Hence, these NPs may raise a potential risk to crops cultivated in soils. Moreover, the physiological effects of nCuO on green onion (Allium fistulosum) and surface-coated nTiO2 on full-grown carrot (Daucus carota L.) are still unknown. Green onion is characterized by its high content of the antioxidant allicin, and carrot is a worldwide economic …

Abstraction Techniques In Security Games With Underlying Network Structure, Anjon Basak

Open Access Theses & Dissertations

In a multi-agent system, multiple intelligent agents interact with each other in an environment to achieve their objectives. They can do this because they know which actions are available to them and which actions they prefer to take in a particular situation. The job of game theory is to analyze the interactions of the intelligent agents by different solution techniques and provide analysis such as predicting outcomes or recommending courses of action to specific players. To do so game theory works with a model of real-world scenarios which helps us to make a better decision in our already complex daily …

Comparative Experimental And Theoretical Study Of Dopamine And Serotonin Interaction, Jose A. Guerrero

Open Access Theses & Dissertations

To accurately identify and measure the concentrations of dopamine (DA) and serotonin (5-HT) in mixtures of these neurotransmitters without labeling, a comprehensive, comparative computational and Raman experimental analysis is provided. While the distinction between these two analytes may be accomplished for concentrations in the millimolar range of these mixtures, their accurate quantification remains unattainable. As shown for the first time in this study, potential creation of a new composite resulting from their interactions with each other could be a reason for this lack of quantification.

Although this new hydrogen-bonded complex greatly complicates future analyte differentiation and quantification at concentrations typical …

Utilizing Zircon (U-Th)/He And 40ar/39ar Thermochronology To Refine The Thermal History Of The Great Unconformity Within New Mexico And Colorado, Jacoup Roiz

Open Access Theses & Dissertations

The Great Unconformity beneath Paleozoic strata represents 100-1000 m.y. of missing rock record that formed through extensive weathering and erosion. Despite its global extent, the timing of Precambrian crystalline rock exhumation prior to Phanerozoic sediment deposition remains relatively unresolved in many locations. I utilized zircon (U-Th)/He (ZHe) thermochronology in order to constrain the long-term thermal history of Precambrian rocks in Colorado and New Mexico, and test my hypoThesis that these units below the Great Unconformity experienced multiple cooling and reheating episodes resulting in a compound surface representing multiple unconformities. In addition to a synThesis of previously reported data in the …

Development On Of An Unmanned Aerial Vehicle-Based Orangutan Population Assessment And Monitoring Method For The Multifunctional Landscape Of East Kalimantan, Indonesia, Muhammad Sugihono Hanggito

Open Access Theses & Dissertations

Deforestation, habitat degradation, and other forms of land conversion are threatening the existence of orangutans (Pongo spp.), the critically endangered great apes that only live on the two large Sunda-shelf islands of Sumatra and Borneo. Currently, orangutan populations persist not only within conservation or protected areas but also in other functional landscapes such as forest/acacia plantations, oil palm plantations, and mining concessions. The presence of orangutan populations in this recently modified multifunctional landscape has the potential to exacerbate human-orangutan conflict, which could further threaten orangutan populations. Lack of information about the distribution and size of orangutan populations hampers long term …

Planar Motion Control Of A Cube Satellite Using Cold Gas Thrusters, Christian Lozoya

Open Access Theses & Dissertations

This Thesis presents a mathematical model developed for the computational simulation ofCubeSat movement using four thrusters that permit uniaxial translation and rotation. Arbitrary functions are fit to boundary conditions to simulate the force, acceleration, velocity, and displacement of the CubeSat along a plane. The model is used to derive a motion control algorithm assuming constant pressure and mass. A single model describes both translation and rotation. This Thesis also explores the relationship between propellant consumption and the time required to complete a displacement implied by the model.

Method Development For The Analysis Of Fatty Acids In Adipose Tissue Using Stir Bar Sorptive Extraction Coupled With Gas Chromatography-Mass Spectrometry, Angela Marisol Encerrado Manriquez

Open Access Theses & Dissertations

The project was aimed to develop an easy and sensitive analytical tool to study the role of fatty acids (FAs) profile in periprostatic adipose tissue (PPAT) and prostate cancer (PCa). PCa is the second leading cause of cancer-related death among American men. Although obesity has been mostly ruled out by many researchers as a risk factor for developing PCa, it has shown to be associated with PCa metastasis and progression. Periprostatic adipose tissue, which was present on 48% of prostatic surfaces, has been reported to act as energy sources for facilitating a positive microenvironment for PCa tumor progression. To understand …

Predicting Stochastic Volatility For Extreme Fluctuations In High Frequency Time Series, Md Al Masum Bhuiyan

Open Access Theses & Dissertations

This work is devoted to the study of modeling high frequency time series including extreme fluctuations. As the high frequency data are collected at extremely fine scales, the fluctuations can capture the dynamics of data that evolve over time. A class of volatility models with time-varying parameters is used to forecast the volatility in a stationary condition at different lags. The modeling of stationary time series with consistent properties facilitates prediction with much certainty.

A large set of high frequency financial returns, closing prices of stock markets, high magnitudes of seismograms generated by the natural earthquakes, and the mining explosions …

Using Prosody To Spot Location Mentions, Gerardo Cervantes

Open Access Theses & Dissertations

Identifying location mentions in speech is important for many information retrieval and information extraction tasks; here I explore the use of prosody for location spotting. While previous work has explored the use of prosody for spotting named entities, including locations, the specific value of prosody for finding locations in spontaneous speech has not been measured. Using the Switchboard corpus and LSTM modeling I obtain results indicating that prosody is useful in spotting location mentions. Further, I identify specific prosodic

features that tend to mark locations in American English.

Autonomous Trading Strategies For Dynamic Energy Markets, Moinul Morshed Porag Chowdhury

Open Access Theses & Dissertations

With increasing energy demand and an intermittent supply of renewable energy sources, our current energy grid needs a transformation towards a more robust, reliable energy trading architecture. The smart grid promises this architecture as the future of the present energy market, where traders will use digital technologies to automate the management of power delivery. It will improve many issues of the current energy grid such as sustainable, clean, renewable, reliable and secure energy supply, customer participation in markets, distributed generation, and transparency in energy trading. Using autonomous trading agents, we can bridge several dynamic energy markets and ensure an efficient …

Uranium Series Dating And Geochemistry Of Fault Zone Precipitated Secondary Carbonates: Insights Into Paleo Fluid Sources, Tectonics And Climate In The Rio Grande Rift, Victor Higareda Garcia

Open Access Theses & Dissertations

Fault zones in the shallow crust impact a variety of geological processes including mineral deposition, fluid flow patterns in shallow and deep groundwater aquifers, and most importantly seismic activity. The specific interplays of fault zones, seismicity, and groundwater flows are complex and not well understood despite the importance they have to society. The Rio Grande rift is a region impacted by seismic and volcanic activity that place the first order control on mineral formation and fluid flow patterns. It is also a region that is often disregarded as a seismic hazard due to its inferred low tectonic rates and long …

Machine Learning Analysis To Characterize Phase Variations In Laser Propagation Through Deep Turbulence, Luis Fernando Rodriguez Sanchez

Open Access Theses & Dissertations

The present Dissertation is focused on the analysis of the atmospheric conditions of a turbulent environmental system and its effects on the diffraction of a laser beam that moves through it. The study is based on the optical communication of two labs placed at the summit of two mountains located in Maui, Hawaii. The emitter system is located at the Mauna Loa mountain and the receiver at the Haleakala. The distance between both mountains is 150 km. The emitter system is at a height of 3.1 km and the receiver at 3.4 km. The maritime environment at the location experiences …

Positivity-Preserving Segregate-Flux Method For Infiltration Dynamics In Tumor Growth Models, Gilbert Danso Acheampong

Open Access Theses & Dissertations

We study the positivity preserving property and an incompressibility condition in a recently proposed tumor growth model as well as its numerical simulations. In this model, the biological process is described by a free-boundary problem of hyperbolic equations that govern the in-tumor motion of cancer cells and the infiltration of immune cells. Particularly, due to an assumption that cells take constant volume (the incompressibility condition), the tumor growth/shrinkage is closely correlated to the magnitude of infiltration of immune cells into the tumor.

Despite the fact that previous simulation results largely reproduced experimental data, there remain unanswered questions that are crucial …

Using Machine Learning On An Imbalanced Cancer Dataset, James Ekow Arthur

Open Access Theses & Dissertations

With an estimated 1.4 million cancer diagnosis worldwide and the increasing death of cancer patients. It is prudent to investigate methods, approaches and smarter ways of predicting and diagnosing of cancer so that a holistic techniques can be used to curb or reduce false predictions , increase exact predictions and also meticulos prognosis information .

Can a feasible technique be developed for the general problem of prognosis and diagnosis of cancer be developed ?

We will show here that this problem of cancer prognosis and diagnosis can be efficiently tackled with the aid of machine learning techniques and the best, …

Application Of Non-Seismic Methods To Analyze And Model The Geometry Of The Northern Margin Of The Onion Creek Salt Diapir, Paradox Basin, Utah, Julia Michelle Astromovich

Open Access Theses & Dissertations

The Onion Creek salt diapir lies within the Paradox Basin of Utah where it forms part of a series of salt walls that separate the Paradox Basin into smaller sub-basins. These sub-basins and associated salt diapirs remain key to several oil and gas traps in the region. A series of anomalous tight folds occur on the northern side of the Onion Creek diapir within the Permian Cutler Group Undifferentiated. These folds are thought to be associated with a shallow detachment horizon with three possible origins:1) a weak shale layer within the Cutler Group, 2) a salt shoulder, or 3) a …

Comparing Predictive Performance Of Statistical Learning Models On Medical Data, Francis Biney

Open Access Theses & Dissertations

This work investigates the predictive performance of 10 Machine learning models on three medical data including Breast cancer, Heart disease and Prostate cancer. Furthermore, we use the models to identify risk factors that contribute significantly to these diseases.

The models considered include; Logistic regression with L1 and L_2 penalties, Principal component logistic regression(PCR-LR), Partial least squares logistic regression(PLS-LR), Multivariate adaptive regression splines(MARS), Support vector machine with Radial Basis Kernel (SVM-RBK), Random Forest(RF), Gradient Boosting Machines(GBM), Elastic Net (Enet) and Feedforward Neural Network(FFNN). The models were grouped according to their similarities and learning style; i) Linear regularized models: LR-Lasso, LR-Ridge and …

Optimization Of Regional Scale Numerical Weather Prediction & Air Quality Model For The Paso Del Norte Region, Suhail Mahmud

Open Access Theses & Dissertations

Improvement of the Accuracy and Forecast capability of the Numerical Weather Prediction (NWP) models and Air Quality Models (AQM) are critical issues in today's scientific study of Meteorology and Air Pollution. The models for these predictions are dependent on topography, climate, initial and boundary conditions, domain size, and computational efficiency. Different techniques such as Data Assimilation, Ensemble Methods, Increased Computing Capacity to achieve higher model resolution, and Improved Physics Schemes can be used to address this problem. In this study, the NWP models, the Weather and Research Forecast (WRF), and the HYSPLIT models, were enhanced for the Paso Del Norte …