Physical Sciences and Mathematics Commons^™

Advanced Analytical Strategies To Determine Biomedical Parameters For Medical Diagnostics, Drug Delivery, And Therapy, Sisi Chen

Doctoral Dissertations

"Biomedical parameters are critical for diseases prognosis, diagnosis and therapy. Many research groups have dedicated their studies to develop analytical instrumentation and apply analytical methods to determine biomedical parameters that have the potential to help with disease control and increase public health. This dissertation focuses on three major aspects of analytical strategies development and applications: 1) detection of pH changes caused by nanotoxicity (induced by TiO₂ nanoparticles) using newly developed micro-pH sensor, 2) quantification of renal cell carcinoma (RCC) biomarkers by high-performance liquid chromatography - tandem mass spectrometry (HPLC-MS/MS), and 3) nuclear magnetic resonance (NMR) studies of porous wall …

Zero-Dimensional Spaces And Their Inverse Limits, Sahika Sahan

Doctoral Dissertations

"In this dissertation we investigate zero-dimensional compact metric spaces and their inverse limits. We construct an uncountable family of zero-dimensional compact metric spaces homeomorphic to their Cartesian squares. It is known that the inverse limit on [0,1] with an upper semi-continuous function with a connected graph has either one or infinitely many points. We show that this result cannot be generalized to the inverse limits on simple triods or simple closed curves. In addition to that, we introduce a class of zero-dimensional spaces that can be obtained as the inverse limits of arcs. We complete by answering a problem by …

Rapid Quantification Of Trypsin Inhibitors In Food And Feed Formulations With Electrospray Ionization Mass Spectrometry, Radheshyam Panta

Doctoral Dissertations

"Presence of anti- nutrients deteriorate the nutritional value of animal foods and feed formulations. The important one being trypsin inhibitors. Trypsin inhibitors in food and feed formulations lower the protein supplement and hence the ultimate consequence is the decrease in growth and development of animals. It is therefore, crucial to monitor trypsin inhibitors in animal food and feed formulations. Research work mentioned in this dissertation is based on the development of rapid, more accurate and robust method for determination of trypsin inhibitor in food and feed formulations. The developed method includes extraction of trypsin inhibitor from food and feed formulation …

Layered Crustal And Mantle Structure And Anisotropy Beneath The Afar Depression And Malawi Rift Zone, Cory Alexander Reed

Doctoral Dissertations

"Although a wealth of geophysical data sets have been acquired within the vicinity of continental rift zones, the mechanisms responsible for the breakup of stable continental lithosphere are ambiguous. Eastern Africa is host to the largest contemporary rift zone on Earth, and is thus the most prominent site with which to investigate the processes which govern the rupture of continental lithosphere. The studies herein represent teleseismic analyses of the velocity and thermomechanical structure of the crust and mantle beneath the Afar Depression and Malawi Rift Zone (MRZ) of the East African Rift System. Within the Afar Depression, the first densely-spaced …

A Functional Data Analytic Approach For Region Level Differential Dna Methylation Detection, Mohamed Salem F. Milad

Doctoral Dissertations

"DNA methylation is an epigenetic modification that can alter gene expression without a DNA sequence change. The role of DNA methylation in biological processes and human health is important to understand, with many studies identifying associations between specific methylation patterns and diseases such as cancer. In mammals, DNA methylation almost always occurs when a methyl group attaches to a cytosine followed by a guanine (i.e. CpG dinucleotides) on the DNA sequence. Many statistical methods have been developed to test for a difference in DNA methylation levels between groups (e.g. healthy vs disease) at individual cytosines. Site level testing is often …

Receiver Function Imaging Of Mantle Transition Zone Discontinuities Beneath Alaska, Haider Hassan Faraj Dahm

Doctoral Dissertations

"Subduction of tectonic plates is one of the most important tectonic processes, yet many aspects of subduction zone geodynamics remain unsolved and poorly understood, such as the depth extent of the subducted slab and its geometry. The Alaska subduction zone, which is associated with the subduction of the Pacific Plate beneath the North America plate, has a complex tectonic setting and carries a series of subduction episodes, and represents an excellent target to study such plate tectonic processes. Previous seismological studies in Alaska have proposed different depth estimations and geometry for the subducted slab. The Mantle transition zone discontinuities of …

Modeling Dynamic Community Acceptance Of Mining Using Agent-Based Modeling, Mark Kofi Boateng

Doctoral Dissertations

"This research attempts to provide fundamental understanding into the relationship between perceived sustainability of mineral projects and community acceptance. The main objective is to apply agent-based modeling (ABM) and discrete choice modeling to understand changes in community acceptance over time due to changes in community demographics and perceptions. This objective focuses on: 1) formulating agent utility functions for ABM, based on discrete choice theory; 2) applying ABM to account for the effect of information diffusion on community acceptance; and 3) explaining the relationship between initial conditions, topology, and rate of interactions, on one hand, and community acceptance on the other …

Theoretical Calculations For Electron Impact Ionization Of Atoms And Molecules, Sadek Mohamed Fituri Amami

Doctoral Dissertations

"In the last twenty years, significant progress has been made for the theoretical treatment of electron impact ionization (e,2e) of atoms and molecules and, for some cases, very nice agreement between experiment and theory has been achieved. In particular, excellent agreement between theory and experiment and theory has been achieved for ionization of hydrogen and helium. However, agreement between experiment and theory is not nearly as good for ionization of larger atoms and molecules. In the first part of this dissertation, different theoretical approaches will be employed to study the triply differential cross section (TDCS) for low and intermediate energy …

Cognition-Based Approaches For High-Precision Text Mining, George John Shannon

Doctoral Dissertations

"This research improves the precision of information extraction from free-form text via the use of cognitive-based approaches to natural language processing (NLP). Cognitive-based approaches are an important, and relatively new, area of research in NLP and search, as well as linguistics. Cognitive approaches enable significant improvements in both the breadth and depth of knowledge extracted from text. This research has made contributions in the areas of a cognitive approach to automated concept recognition in.

Cognitive approaches to search, also called concept-based search, have been shown to improve search precision. Given the tremendous amount of electronic text generated in our digital …

Numerical Investigation On Nonlocal Problems With The Fractional Laplacian, Siwei Duo

Doctoral Dissertations

"Nonlocal models have recently become a powerful tool for studying complex systems with long-range interactions or memory effects, which cannot be described properly by the traditional differential equations. So far, different nonlocal (or fractional differential) models have been proposed, among which models with the fractional Laplacian have been well applied. The fractional Laplacian (-Δ)^α/2 represents the infinitesimal generator of a symmetric α-stable Lévy process. It has been used to describe anomalous diffusion, turbulent flows, stochastic dynamics, finance, and many other phenomena. However, the nonlocality of the fractional Laplacian introduces considerable challenges in its mathematical modeling, numerical simulations, and mathematical …

Discrete Ordinates Ct Organ Dose Simulator (Doctors), Edward T. Norris

Doctoral Dissertations

"Computed tomography (CT) has become pervasive in medical diagnostics as improved imaging techniques and processing algorithms provide higher quality information to doctors. However, the exponentially increasing usage of CT has raised concerns regarding long term low-dose radiological risks.

Currently, the dose to patients is computed using Monte Carlo methods and experimental tests. In other areas of radiation transport, deterministic codes have been shown to be much faster than Monte Carlo codes.

Currently, no deterministic methodology exists to automatically generate a spatially distributed dose profile from a CT voxel phantom. This work proposes a new code, Discrete Ordinate CT Organ Dose …

Application Of Nearly Linear Solvers To Electric Power System Computation, Lisa L. Grant

Doctoral Dissertations

"To meet the future needs of the electric power system, improvements need to be made in the areas of power system algorithms, simulation, and modeling, specifically to achieve a time frame that is useful to industry. If power system time-domain simulations could run in real-time, then system operators would have situational awareness to implement and avoid cascading failures, significantly improving power system reliability. Several power system applications rely on the solution of a very large linear system. As the demands on power systems continue to grow, there is a greater computational complexity involved in solving these large linear systems within …

Environmental Hazard Identification, Assessment And Control For A Sustainable Maritime Transportation System, Lizzette Marie Pérez Lespier

Doctoral Dissertations

"A demand exists to contribute towards the widening awareness of the need for sustainable maritime development and for coordinated maritime policies worldwide. Maritime shipping is considered the most eco-efficient mean of transportation and yet, is responsible for negative environmental impacts.

This dissertation focuses on developing data-driven decision support tools to evaluate the sustainable performance of MTS by focusing on the elements of the MTS that place stress on the environment. The first research contribution is a System Dynamics simulation model that examines the MTS resiliency after an extreme event and determines the sequence needed to restore the ocean-going port to …

Programming Problems On Time Scales: Theory And Computation, Rasheed Basheer Al-Salih

Doctoral Dissertations

"In this dissertation, novel formulations for several classes of programming problems are derived and proved using the time scales technique. The new formulations unify the discrete and continuous programming models and extend them to other cases "in between." Moreover, the new formulations yield the exact optimal solution for the programming problems on arbitrary isolated time scales, which solve an important open problem. Throughout this dissertation, six distinct classes of programming problems are presented as follows. First, the primal as well as the dual time scales linear programming models on arbitrary time scales are formulated. Second, separated linear programming primal and …

Designing High Performance Overall Water Splitting Electrocatalysts From Non-Precious Metal Selenides, Abdurazag T. Swesi

Doctoral Dissertations

“The energy production has been depending mostly on fossil fuel which will be depleted someday in the near future. Aspects such as the loss of energy resources and destruction of the environment have motivated researchers for pursuing transition away from fossil fuels to renewable solar-fuels. Therefore, in order to meet the continuous increasing demand for energy, the hydrogen, with the largest energy density stored in it, can then efficiently be used in fuel cells without concern of contaminants. Water splitting reaction to generate H₂ and O₂ is one promising method of converting solar energy into fuels. The major …

A Harmonic M-Factorial Function And Applications, Reginald Alfred Brigham Ii

Doctoral Dissertations

"We offer analogs to the falling factorial and rising factorial functions for the set of harmonic numbers, as well as a mixed factorial function called the M-factorial. From these concepts, we develop a harmonic analog of the binomial coefficient and an alternate expression of the harmonic exponential function and establish several identities. We generalize from the harmonic numbers to a general time scale and demonstrate how solutions to some second order eigenvalue problems and partial dynamic equations can be constructed using power series built from the M-factorial function"--Abstract, page iii.

Geophysical Interpretation And Static Reservoir Modeling Of Structurally Complex Reservoir, Rg Oil Field Area, Sirte Basin, Libya, Abdalla A. Abdelnabi

Doctoral Dissertations

"Cambrian-Ordovician and Upper Cretaceous reservoir formations are found in the central western Sirte Basin, the main oil producing region in the Sirte Basin, Libya. As a result of changes in sedimentary environments and structural activities, a number of irregularities in reservoir continuity have developed, which negatively affected the overall performance of the reservoir. Effective simulation of such complex reservoirs can be achieved by integrating geophysical, geological, and petrophysical data to construct a reliable full-field static model, which has the potential to simulate the vertical and lateral variations in the reservoir formations. In this study, 2D and 3D seismic data acquired …

Long-Range Interatomic Interactions: Oscillatory Tails And Hyperfine Perturbations, Chandra Mani Adhikari

Doctoral Dissertations

"We study the long-range interaction between two hydrogen atoms, in both the van der Waals and Casimir-Polder regimes. The retardation regime is reached when the finiteness of the speed of light becomes relevant. Provided that both atoms are in the ground states, the retardation regime is achieved when the interatomic distance, R, is larger than 137 a₀, where a₀ is the Bohr radius.

To study the interaction between two hydrogen atoms in 1S and 2S states, we differentiate three different ranges for the interatomic distance: van der Waals range (a₀ « R « a₀/α, where α is the fine structure …

Synthesis, Characterization, And Activity Of Co/Fe Alumina/Silica Supported Ft Catalysts And The Study Of Promoter Effect Of Ruthenium, Sunday Azubike Esumike

Doctoral Dissertations

The alumina and hybrid alumina-silica FT catalyst were prepared by one-step solgel/oil-drop methods using metal-nitrate-solutions (method-I), and nanoparticle-metaloxides (method-2). The nanoparticle-metal-oxides did not participate in solubility equilibria in contrast to metal nitrate in method-1 causing no metal ion seepage; therefore, method-2 yields higher XRF metal loading efficiency than method-1. The thermal analysis confirmed that the metal loading by method-1 and method-2 involved two different pathways. Method-1 involves solubility equilibria in the conversion of metal-nitrate to metal- hydroxide and finally to metal-oxide, while in method-2 nanoparticle-metal-oxide remained intact during sol-gel-oil-drop and calcination steps.

The alumina supported catalysts were dominated by γ-alumina …

Balanced Truncation Model Reduction Of Nonlinear Cable-Mass Pde System, Madhuka Hareena Lochana Weerasinghe

Doctoral Dissertations

We consider model order reduction of a cable-mass system modeled by a one dimensional wave equation with interior damping and dynamic boundary conditions. The system is driven by a time dependent forcing input to a linear mass-spring system at the left boundary of the cable. A mass-spring model at the right end of the cable includes a nonlinear stiffening force. The goal of the model reduction is to produce a low order model that produces an accurate approximation to the displacement and velocity of the mass in the nonlinear mass-spring system at the right boundary. We believe the nonlinear cable-mass …

Biomarker Discovery Using Urinary Metabolomics For Noninvasive Early Cancer Detection, Casey Franklin Burton

Doctoral Dissertations

"The development of new screening methods for the early detection of cancer remains one of the foremost challenges facing modern cancer research. The emergence of new analytical technologies and their application to 'omics'-based approaches has provided researchers with powerful new tools for molecular biomarker discovery that may benefit early screening of cancer. This dissertation outlines several key advances made toward the application of urinary metabolomics to cancer biomarker discovery. The term urinary metabolomics here refers to the investigation of small metabolites in urine as potential disease biomarkers. The advantage of using this approach lies in its noninvasive sampling characteristics and …

Fusion Of Non-Visual And Visual Sensors For Human Tracking, Wenchao Jiang

Doctoral Dissertations

"Human tracking is an extensively researched yet still challenging area in the Computer Vision field, with a wide range of applications such as surveillance and healthcare. People may not be successfully tracked with merely the visual information in challenging cases such as long-term occlusion. Thus, we propose to combine information from other sensors with the surveillance cameras to persistently localize and track humans, which is becoming more promising with the pervasiveness of mobile devices such as cellphones, smart watches and smart glasses embedded with all kinds of sensors including accelerometers, gyroscopes, magnetometers, GPS, WiFi modules and so on. In this …

Dirac Surface States Of Magnetic Topological Insulators, Seng Huat Lee

Doctoral Dissertations

"Magnetic topological insulator (TI) has been theoretically proposed to be a platform for inducing magnetic monopole and exhibit fascinating quantum phenomena, whereas topological superconductor can host Majorana fermions, particles that are their own antiparticles, which can be manipulated for topological quantum computing. In this dissertation, we experimentally demonstrated that by intercalation of different transition metals in the van der Waals gaps of Bi₂Se₃ TI, magnetism and even superconductivity can be induced. In Fe_xBi₂Se₃, antiferromagnetism is induced with a transition temperature at ~ 100 K. Coexistence of the Dirac surface state with …

Data Analytics Methods For Attack Detection And Localization In Wireless Networks, Yi Ling

Doctoral Dissertations

"Wireless ad hoc network operates without any fixed infrastructure and centralized administration. It is a group of wirelessly connected nodes having the capability to work as host and router. Due to its features of open communication medium, dynamic changing topology, and cooperative algorithm, security is the primary concern when designing wireless networks. Compared to the traditional wired network, a clean division of layers may be sacrificed for performance in wireless ad hoc networks. As a result, they are vulnerable to various types of attacks at different layers of the protocol stack. In this paper, I present real-time series data analysis …

Depositional Systems, Sequence Architecture, And Controlling Factors Of An Eocene Stratigraphic Sequence At Minfeng Steep Margin Of Dongying Depression, Eastern China, Zhixin Li

Doctoral Dissertations

“This study is carried out in Minfeng area, the steep margin of Dongying half graben, eastern China, by integrating 3-D seismic, wireline log, and core data, and aims to interpret the depositional systems, reconstruct sequence stratigraphic architecture, and understand the controlling processes and factors at the steep margin of a rift basin. In the first part of this work, an Eocene stratigraphic sequence is divided into three systems tracts, corresponding to different stages of lake evolution, as early expansion (EEST), late expansion-early contraction (LEECST), and late contraction (LCST). EEST is the thickest and diagnostic by the best-developed marginal and basinal …

Optimization Of Solvent Suppression Sequences For Nmr Analysis Of Aqueous Solutions, Annalise Rose Pfaff

Doctoral Dissertations

"When the use of deuterated solvents is precluded in the NMR analysis of biomolecules in their natural environment, pre-saturation solvent suppression pulse sequences are frequently employed to avoid interference from the overbearing solvent signal. However, these sequences generally require extensive re-adjustment of NMR parameters between samples. For this reason, the EXCEPT (EXponentially Converging Eradication Pulse Train) solvent suppression sequence was developed, which exhibits a tolerance of over an order of magnitude in sample T₁ variation. EXCEPT uses an innovative version of "inversion-recovery nulling" with frequency-selective, low-power adiabatic pulses and exponentially decreasing interpulse delays that effectively reduce solvent net magnetization by …

The Use Of Geophysical Methods For Dam Seepage Investigations And Dredged Oyster Deposit Characterization, Stanley Chinedu Nwokebuihe

Doctoral Dissertations

"The dissertation is made up of three papers, which discuss the utility of geophysical tools in earthfill dam investigations and dredged oyster bed characterization.

In the first paper, an earthfill dam in Warren County, Missouri was effectively investigated for seepage through the dam and its outlet works using an integration of the electrical resistivity tomography, induced polarization and spontaneous potential geophysical tools. Recommendations were subsequently made based on the results of the study on grout locations to prevent further seepage. In the second paper, a similar study of earthfill dam seepage was conducted on a different dam in Southern Missouri. …

Dissolution-Enlarged Fractures Imaging Using Electrical Resistivity Tomography (Ert), Elnaz Siami-Irdemoosa

Doctoral Dissertations

"In recent years the electrical imaging techniques have been largely applied to geotechnical and environmental investigations. These techniques have proven to be the best geophysical methods for site investigations in karst terrain, particularly when the overburden soil is clay-dominated. Karst is terrain with a special landscape and distinctive hydrological system developed by dissolution of rocks, particularly carbonate rocks such as limestone and dolomite, made by enlarging fractures into underground conduits that can enlarge into caverns, and in some cases collapse to form sinkholes.

Bedding planes, joints, and faults are the principal structural guides for underground flow and dissolution in almost …

Application Of Quantum Monte Carlo Methods To Molecular Potential Energy Surfaces, Andrew Douglas Powell

Doctoral Dissertations

"Various computational methods have been used to generate potential energy surfaces, which can help us simulate and interpret how atoms or molecules behave during a chemical reaction. For accurate work, ab initio wavefunction methods have traditionally been used, which have some disadvantages. For example, highly accurate methods scale poorly with system size (n⁷ or higher) and are mostly not well parallelized for calculations with multiple processors. One alternative method that has more favorable scaling with system size and is well parallelized is a computational technique called quantum Monte Carlo (QMC). QMC methods scale with the number of electrons as …

Bootstrap-Based Confidence Intervals In Partially Accelerated Life Testing, Ahmed Mohamed Eshebli

Doctoral Dissertations

"Accelerated life testing (ALT) is utilized to estimate the underlying failure distribution and related parameters of interest in situations where the components under study are designed for long life and therefore will not yield failure data within a reasonable test period. In ALT, life testing is carried out under two or more higher than normal stress levels, with the resulting acceleration of the failure process yielding a sufficient amount of un-censored life-span data within a practical test duration. Usually one (or more) parameters of the life distribution is linked to the stress level through a suitably selected model based on …