Physical Sciences and Mathematics Commons^™

Geology And Fossils Of North Central Texas (Fort Worth To Mineral Wells): Texas Academy Of Science February 28 2021, R. Larell Nielson

Faculty Publications

The 2021 Texas Academy of Science Geology field trip will be a virtual field trip that you may run at any time. It will have two parts;Part 1 consists of a video discussion of each stop( https://www.youtube.com/watch?v=EJKSgqtLvw0)and Part 2 consists of this field trip guidebook (for use when visiting each of the locations). The field trip will start at Holiday Park,near Benbrook,southwest of Fort Worth,Texas, and will end at the Mineral Wells Fossil Park, west of Minerals Wells, Texas. T

Dietary Quality And Dietary Inflammatory Potential During Pregnancy And Offspring Emotional And Behavioral Symptoms In Childhood: An Individual Participant Data Meta-Analysis Of Four European Cohorts, Kinga Polanska, Pawel Kaluzny, Adrien M. Aubert, Liesbeth Duijts, Hanan El Marroun, Wojciech Hanke, James R. Hébert, Barbara Heude, Agnieszka Jankowska, Giulia Mancano, Sara M. Mensink-Bout, Caroline Relton, Nitin Shivappa Mbbs, Mph, Ph.D., Matthew Suderman, Elzbieta Trafalska, Ewelina Wesolowska, Raquel Garcia-Esteban, Mònica Guxens, Maribel Casas, Catherine M. Phillips

Faculty Publications

Background

The impact of maternal diet during pregnancy on child neurodevelopment is of public health and clinical relevance. We evaluated the associations of dietary quality based on the Dietary Approaches to Stop Hypertension (DASH) score and dietary inflammatory potential based on the energy-adjusted Dietary Inflammatory Index (E-DII) score during pregnancy with emotional and behavioral symptoms of offspring at 7 to 10 years of age.

Methods

Individual participant data for 11,870 mother–child pairs from four European cohorts participating in the ALPHABET project were analyzed. Maternal antenatal DASH and E-DII scores were generated from self-completed food frequency questionnaires. Symptoms of depression …

Insect Reproductive Behaviors Are Important Mediators Of Carrion Nutrient Release Into Soil, Brooke K. Woelber-Kastner, Serita D. Frey, Daniel R. Howard, Carrie L. Hall

Faculty Publications

Current declines in terrestrial insect biomass and abundance have raised global concern for the fate of insects and the ecosystem services they provide. However, the ecological and economic contributions of many insects have yet to be quantified. Carrion-specializing invertebrates are important mediators of carrion decomposition; however, the role of their reproductive activities in facilitating this nutrient pulse into ecosystems is poorly understood. Here, we investigate whether insects that sequester carrion belowground for reproduction alter soil biotic and abiotic properties in North American temperate forests. We conducted a field experiment that measured soil conditions in control, surface carrion alone, and beetle-utilized …

Measurement Of Time-Dependent Cp Violation Parameters In B0 → K0 S K0 S K0 S Decays At Belle, K. H. Kang, H. Park, T. Higuchi, K. Miyabayashi, K. Miyabayashi, K. Sumisawa, I. Adachi, J. K. Ahn, H. Aihara, S. Al Said, D. M. Asner, V. Aulchenko, T. Aushev, R. Ayad, V. Babu, S. Bahinipati, A. M. Bakich, P. Behera, Milind Purohit, Et. Al.

Faculty Publications

We measure the time-dependent CPviolation parameters in B0 → K⁰ _S K⁰ _S K⁰ _S decays using 772 × 10⁶ BB̅ pairs collected at the ϒ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e⁺e⁻ collider. The obtained mixing-induced and direct CP asymmetries are −0.71 ± 0.23 (stat) ± 0.05 (syst) and 0.12 ± 0.16 (stat) ± 0.05 (syst), respectively. These values are consistent with the Standard Model predictions. The significance of CP violation differs from zero by 2.5 standard deviations.

Measurement Of Time-Dependent Cp Violation Parameters In B0 → K0 S K0 S K0 S Decays At Belle, K. H. Kang, H. Park, T. Higuchi, K. Miyabayashi, K. Sumisawa, I. Adachi, J. K. Ahn, H. Aihara, S. Al Said, D. M. Asner, V. Aulchenko, T. Aushev, R. Ayad, V. Babu, S. Bahinipati, A. M. Bakich, P. Behera, C. Beleño, J. Bennett, Milind Purohit, Et. Al.

Faculty Publications

We measure the time-dependent CP violation parameters in B0 → K⁰ _S K⁰ _S K⁰ _S decays using 772 × 10⁶ BB̅ pairs collected at the ϒ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e⁺e⁻ collider. The obtained mixing-induced and direct CP asymmetries are −0.71 ± 0.23 (stat) ± 0.05 (syst) and 0.12 ± 0.16 (stat) 0.05 (syst), respectively. These values are consistent with the Standard Model predictions. The significance of CP violation differs from zero by 2.5 standard deviations.

The Intersection Of Rural Residence And Minority Race/Ethnicity In Cancer Disparities In The United States, Whitney Zahnd, Cathryn Murphy, Marie Knoll, Gabriel A. Benavidez, Kelsey R. Day, Radhika Ranganathan, Parthenia Luke, Anja Zgodic, Kewei Shi, Melinda A. Merrell, Elizabeth L. Crouch, Heather M. Brandt, Jan Eberth

Faculty Publications

One in every twenty-five persons in America is a racial/ethnic minority who lives in a rural area. Our objective was to summarize how racism and, subsequently, the social determinants of health disproportionately affect rural racial/ethnic minority populations, provide a review of the cancer disparities experienced by rural racial/ethnic minority groups, and recommend policy, research, and intervention approaches to reduce these disparities. We found that rural Black and American Indian/Alaska Native populations experience greater poverty and lack of access to care, which expose them to greater risk of developing cancer and experiencing poorer cancer outcomes in treatment and ultimately survival. There …

Identification Of A Local Sample Of Gamma-Ray Bursts Consistent With A Magnetar Giant Flare Origin, E. Burns, D. Svinkin, K Hurley, Z. Wadiasingh, M. Negro, G. Younes, R. Hamburg, A. Ridnaia, D. Cook, S. B. Cenko, R. Aloisi, G. Ashton, M. Baring, M. S. Briggs, N. Christensen, D. Frederiks, A. Goldstein, C. M. Hui, D. L. Kaplan, M. M. Kasliwal, D. Kocevski, O. J. Roberts, V. Savchenko, A. Tohuvavohu, P. Veres, C. A. Wilson-Hodge

Faculty Publications

Cosmological gamma-ray bursts (GRBs) are known to arise from distinct progenitor channels: short GRBs mostly from neutron star mergers and long GRBs from a rare type of core-collapse supernova (CCSN) called collapsars. Highly magnetized neutron stars called magnetars also generate energetic, short-duration gamma-ray transients called magnetar giant flares (MGFs). Three have been observed from the Milky Way and its satellite galaxies, and they have long been suspected to constitute a third class of extragalactic GRBs. We report the unambiguous identification of a distinct population of four local (<5 Mpc) short GRBs, adding GRB 070222 to previously discussed events. While identified solely based on alignment with nearby star-forming galaxies, their rise time and isotropic energy release are independently inconsistent with the larger short GRB population at >99.9% confidence. These properties, the host galaxies, and nondetection in gravitational waves …

Transepithelial Anti-Neuroblastoma Response To Kale Among Four Vegetable Juices Using In Vitro Model Co-Culture System, John Piletz, Yuhan Mao, Debarshi Roy, Bilal Qizilbash, Eurielle Nkamssi, Enleyona Weir, Jessica Graham, Mary Emmanuel, Suwaira Iqbal, Kellie Brue, Bidisha Roy Sengupta

Faculty Publications

Juicing vegetables is thought to be an anticancer treatment. Support exists for a rank order of anticancer greens (kale > dandelion > lettuce > spinach) based on degrees of bioavailability of different phytochemicals, also offset by some noxious molecules (i.e., calcium-oxalate). We developed a new in vitro transepithelial anti-neuroblastoma model system. The juices were diluted as predicted once in the small intestine. They were applied to apical Caco-2Bbe1 cells atop dividing SH-SY5Y neuroblastoma cells, and changes in transepithelial electrical resistance (TEER) and cell growth were considered with juice spectroscopies. Studied first in monoculture, kale and dandelion were the most cytostatic juices on SH-SY5Ys, …

A Synthesis Of Deepwater Horizon Impacts On Coastal And Nearshore Living Marine Resources, Steven A. Murawski, Joshua P. Kilborn, Adriana C. Bejarano, David Chagaris, David Donaldson, Frank J. Hernandez, Timothy C. Macdonald, Craig Newton, Ernst Peebles, Kelly L. Robinson

Faculty Publications

The 2010 Deepwater Horizon (DWH) oil blowout in the Gulf of Mexico began on April 20, originating in the deep sea 66 km off the Louisiana coast. By early June, DWH oil had spread to coastal Louisiana, Mississippi, Alabama and western Florida. An estimated 2,113 km of shoreline were oiled, making DWH the largest marine oil spill in global history by length of affected shoreline. Additionally, a series of oil spill response measures were deployed, including diversions of Mississippi River discharge to forestall oil coming ashore, and the establishment of large-scale fishery closures, with both affecting coastal resources to varying …

Photoinduced Trapping Of Charge At Sulfur Vacancies And Copper Ions In Photorefractive Sn2P2S6 Crystals, Timothy D. Gustafson, Eric M. Golden, Elizabeth M. Scherrer, Nancy C. Giles, A. A. Grabar, Sergey A. Basun, Jonathan E. Slagle [*], Larry E. Halliburton

Faculty Publications

Electron paramagnetic resonance (EPR) is used to monitor photoinduced changes in the charge states of sulfur vacancies and Cu ions in tin hypothiodiphosphate. A Sn₂P₂S₆ crystal containing Cu+ (3d10) ions at Sn²⁺ sites was grown by the chemical vapor transport method. Doubly ionized sulfur vacancies (V²⁺S) are also present in the as-grown crystal (where they serve as charge compensators for the Cu+ ions). For temperatures below 70 K, exposure to 532 or 633 nm laser light produces stable Cu²⁺ (3d⁹) ions, as electrons move from Cu⁺ ions to …

Zynq System-On-Chip Dma Messaging For Processor Monitoring, Daniel F. Koranek, Douglas D. Hodson, Scott R. Graham

Faculty Publications

Xilinx Zynq-7000 System-on-Chip architectures combine an ARM Cortex-A9 core with an FPGA fabric. One benefit of this hybrid architecture is that it allows fast prototyping of designs where the security of either the processing system (PS) is monitored by the programmable logic (PL) or vice versa. The choice of implementing a design in the PS or PL is driven by cost-to-benefit analysis across many factors. This effort examines the design process required to construct security monitoring designs that use both the PS and PL. For background, this effort reviews similar security monitoring projects. For the effort, a PL peripheral was …

Linking Genes To Traits In Fungi, A. L. Romero-Olivares, Eric W. Morrison, A. Pringle, Serita D. Frey

Faculty Publications

Fungi are mediators of the nitrogen and carbon cycles in terrestrial ecosystems. Examining how nitrogen uptake and organic matter decomposition potential differs in fungi can provide insight into the underlying mechanisms driving fungal ecological processes and ecosystem functioning. In this study, we assessed the frequency of genes encoding for specific enzymes that facilitate nitrogen uptake and organic matter decomposition in 879 fungal genomes with fungal taxa grouped into trait-based categories. Our linked gene-trait data approach revealed that gene frequencies vary across and within trait-based groups and that trait-based categories differ in trait space. We present two examples of how this …

Neighborhood Characteristics And The Mental Health Of Caregivers Cohabiting With Care Recipients Diagnosed With Alzheimer’S Disease, Dana M. Alhasan, Jana A. Hirsch, Chandra L. Jackson, Margaret Chandlee Miller, Bo Cai Ph.D., Matthew C. Lohman Ph.D.

Faculty Publications

While studies have documented the influence of caregiver and care recipient factors on caregiver health, it is important to address the potential impact of neighborhood contexts. This study estimated the cross-sectional associations between neighborhood characteristics and mental health among caregivers cohabiting with Alzheimer’s disease care recipients that were experiencing severe or non-severe neuropsychiatric symptoms (NPSs) (e.g., aggression/anxiety). We obtained data collected in 2010 on caregivers and care recipients (n

While studies have documented the influence of caregiver and care recipient factors on caregiver health, it is important to address the potential impact of neighborhood contexts. This study estimated the cross-sectional …

Accuracy Assessment Of Global Internal-Tide Models Using Satellite Altimetry, Loren Carrere, Brian K. Arbic, Brian Dushaw, Gary Egbert, Svetlana Erofeeva, Florent Lyard, Richard D. Ray, Clement Ubelmann, Edward Zaron, Zhongxiang Zhao, Jay F. Shriver, Maarten Cornelis Buijsman, Nicolas Picot

Faculty Publications

Altimeter measurements are corrected for several geophysical parameters in order to access ocean signals of interest, like mesoscale or sub-mesoscale variability. The ocean tide is one of the most critical corrections due to the amplitude of the tidal elevations and to the aliasing phenomena of high-frequency signals into the lower-frequency band, but the internal-tide signatures at the ocean surface are not yet corrected globally.

Internal tides can have a signature of several centimeters at the surface with wavelengths of about 50–250 km for the first mode and even smaller scales for higher-order modes. The goals of the upcoming Surface Water …

Identify Rna-Associated Subcellular Localizations Based On Multi-Label Learning Using Chou’S 5-Steps Rule, Hao Wang, Yijie Ding, Jijun Tang Ph.D., Quan Zou, Fei Guo

Faculty Publications

Background: Biological functions of biomolecules rely on the cellular compartments where they are located in cells. Importantly, RNAs are assigned in specific locations of a cell, enabling the cell to implement diverse biochemical processes in the way of concurrency. However, lots of existing RNA subcellular localization classifiers only solve the problem of single-label classification. It is of great practical significance to expand RNA subcellular localization into multi-label classification problem.

Results: In this study, we extract multi-label classification datasets about RNA-associated subcellular localizations on various types of RNAs, and then construct subcellular localization datasets on four RNA categories. In order to …

On-Chip Silicon Photonic Controllable 2 × 2 Four-Mode Waveguide Switch, Cao Dung Truong, Duy Nguyen Thi Hang, Hengky Chandrahalim, Minh Tuan Trinh

Faculty Publications

Multimode optical switch is a key component of mode division multiplexing in modern high-speed optical signal processing. In this paper, we introduce for the first time a novel 2 × 2 multimode switch design and demonstrate in the proof-of-concept. The device composes of four Y-multijunctions and 2 × 2 multimode interference coupler using silicon-on-insulator material with four controllable phase shifters. The shifters operate using thermo-optic effects utilizing Ti heaters enabling simultaneous switching of the optical signal between the output ports on four quasi-transverse electric modes with the electric power consumption is in order of 22.5 mW and the switching time …

Beam Spin Asymmetry In Semi-Inclusive Electroproduction Of Hadron Pairs, M. Mirazita, H. Avakian, A. Courtoy, S. Pisano, S. Pisano, S. Adhikari, M. J. Amaryan, Giovanni Angelini, H. Atac, N. A. Baltzell, L. Barion, M. Battaglieri, I. Bedlinskiy, Fatiha Benmokhtar, A. Bianconi, A. S. Biselli, F. Bossù, S. Boiarinov, W. J. Briscoe, W. K. Brooks, Steffen Strauch, Et. Al.

Faculty Publications

A first measurement of the longitudinal beam spin asymmetry 𝐴_𝐿⁢𝑈 in the semi-inclusive electroproduction of pairs of charged pions is reported. 𝐴_𝐿⁢𝑈 is a higher-twist observable and offers the cleanest access to the nucleon twist-3 parton distribution function 𝑒⁡(𝑥). Data have been collected in the Hall-B at Jefferson Lab by impinging a 5.498-GeV electron beam on a liquid-hydrogen target, and reconstructing the scattered electron and the pion pair with the CLAS detector. One-dimensional projections of the 𝐴^{sin⁡𝜙𝑅} _LU moments are extracted for the kinematic variables of interest in the valence quark region. The understanding of dihadron production …

Integrated Profiling Identifies Itgb3bp As Prognostic Biomarker For Hepatocellular Carcinoma, Qiuli Liang, Chao Tan, Feifei Xiao, Fuqiang Yin, Meiliang Liu, Lei Lei, Liuyu Wu, Yu Yang, Jennifer Hui Juan Tan, Shun Liu, Xiaoyun Zeng

Faculty Publications

Hepatocellular carcinoma (HCC) is a highly malignant tumor. In this study, we sought to identify a novel biomarker for HCC by analyzing transcriptome and clinical data. The R software was used to analyze the differentially expressed genes (DEGs) in the datasets GSE74656 and GSE84598 downloaded from the Gene Expression Omnibus database, followed by a functional annotation. A total of 138 shared DEGs were screened from two datasets. They were mainly enriched in the “Metabolic pathways” pathway (Padj = 8.21E-08) and involved in the carboxylic acid metabolic process (Padj = 0.0004). The top 10 hub genes were found by protein-protein interaction …

Search For Slow Magnetic Monopoles With The Nova Detector On The Surface, M. A. Acero, P. Adamson, L. Aliaga, T. Alion, V. Allakhverdian, N. Anfimov, A. Antoshkin, E. Arrieta-Diaz, L. Asquith, A. Aurisano, A. Back, C. Backhouse, M. Biard, N. Balashov, P. Baldi, B. A. Bambah, S. Bashar, K. Bays, S. Bending, R. Bernstein, Roberto Petti, Et. Al.

Faculty Publications

We report a search for a magnetic monopole component of the cosmic-ray flux in a 95-day exposure of the NOvA experiment’s Far Detector, a 14 kt segmented liquid scintillator detector designed primarily to observe GeV-scale electron neutrinos. No events consistent with monopoles were observed, setting an upper limit on the flux of 2 × 10⁻¹⁴ cm⁻² s⁻¹ sr⁻¹ at 90% C.L. for monopole speed 6 × 10⁻⁴ < β < 5 × 10⁻³ and mass greater than 5 × 10⁸ GeV. Because of NOvA’s small overburden of 3 meters-water equivalent, this constraint covers a previously unexplored low-mass region.

Self-Assembled Thermoresponsive Nanogel From Grafted Hyaluronic Acid As A Biocompatible Delivery Platform For Curcumin With Enhanced Drug Loading And Biological Activities, Jittima Amie Luckanagul, Pahweenvaj Ratnatilaka Na Bhuket, Chawanphat Muangnoi, Pranee Rojsitthisak, Qian Wang, Pornchai Rojsitthisak

Faculty Publications

A hyaluronic acid-grafted poly(N-isopropylacrylamide) (HA-pNIPAM) was synthesized as a polymeric nanogel platform for encapsulation and delivery of hydrophobic bioactive compounds using curcumin as a model drug. As demonstrated by transmission electron microscopy and dynamic light scattering techniques, the HA-pNIPAM was simply assembled into spherical nano-sized particles with the thermoresponsive behavior. The success of curcumin aqueous solubilization was confirmed by fluorescent spectroscopy. The resulting nanogel formulation enhanced the aqueous solubility and uptake into NIH-3T3 cells of curcumin. This nanogel formulation also demonstrates cytocompatibility against NIH-3T3 cells, which deems it safe as a delivery vehicle. Moreover, the formulation has a slight skin-protection …

Quantum Statistical Learning Via Quantum Wasserstein Natural Gradient, Simon Becker, Wuchen Li

Faculty Publications

In this article, we introduce a new approach towards the statistical learning problem argminρ(θ )∈P_θ W² _Q(_ρ*, ρ(θ )) to approximate a target quantum state ρ_* by a set of parametrized quantum states ρ(θ ) in a quantum L²-Wasserstein metric. We solve this estimation problem by considering Wasserstein natural gradient flows for density operators on finite-dimensional C^∗ algebras. For continuous parametric models of density operators, we pull back the quantum Wasserstein metric such that the parameter space becomes a Riemannian manifold with quantum Wasserstein information matrix. Using a quantum analogue …

Quantum Statistical Learning Via Quantum Wasserstein Natural Gradient, Simon Becker, Wuchen Li

Faculty Publications

In this article, we introduce a new approach towards the statistical learning problem argmin _p&Theta;is an element of P Θ W_Q²(P *,p(Θ)) to approximate a target quantum state p* by a set of parametrized quantum states p(Θ) in a quantum L²-Wasserstein metric. We solve this estimation problem by considering Wasserstein natural gradient flows for density operators on finite-dimensional C* algebras. For continuous parametric models of density operators, we pull back the quantum Wasserstein metric such that the parameter space becomes a Riemannian manifold with quantum …

Particulate And Dissolved Organic Matter In Stormwater Runoff Influences Oxygen Demand In Urbanized Headwater Catchments, Kelly M. Mccabe, Erik M. Smith, Susan Q. Lang, Claudia Benitez-Nelson

Faculty Publications

Increasing inputs of organic matter (OM) are driving declining dissolved oxygen (DO) concentrations in coastal ecosystems worldwide. The quantity, source, and composition of OM transported to coastal ecosystems via stormwater runoff have been altered by land use changes associated with urbanization and subsequent hydrologic flows that accompany urban stormwater management. To elucidate the role of stormwater in the decline of coastal DO, rain event sampling of biochemical oxygen demand (BOD) in samples collected from the outfall of stormwater ponds and wetlands, as well as samples of largely untreated runoff carried by stormwater ditches, was conducted across a range of urban …

The Tensile Root Strength Of Spartina Patens Declines With Exposure To Multiple Stressors, R. Eugene Turner, Lauris O. Hollis

Faculty Publications

Coastal wetlands may be subjected to numerous biotic and abiotic stressors from natural and anthropogenic forces in the landscape. The influx of nutrients, inorganic compounds and xenobiotics are suspected of degrading the belowground biomass of coastal macrophytes. Spartina patens acts as an ecosystem engineer for lower salinity coastal marshes and its biomechanical properties are vital to the stability and resilience of coastal wetlands. S.patens was exposed to one natural (flooding) and two anthropogenic stressors (atrazine and nutrient addition) in a greenhouse experiment to test the hypothesis that these three stressors reduce the tensile root strength of S. patens. A one-way …

Time-Varying Insomnia Symptoms And Incidence Of Cognitive Impairment And Dementia Among Older Us Adults, Nicholas V. Resciniti, Valerie Yelverton, Bezawit Eyob Kase, Jiajia Zhang, Matthew C. Lohman

Faculty Publications

There is conflicting evidence regarding the association between insomnia and the onset of mild cognitive impairment (MCI) or dementia. This study aimed to evaluate if time-varying insomnia is associated with the development of MCI and dementia. Data from the Health and Retirement Study (n = 13,833) from 2002 to 2014 were used (59.4% female). The Brief Insomnia Questionnaire was used to identify insomnia symptoms which were compiled in an insomnia severity index, ranging from 0 to 4. In analysis, participants’ symptoms could vary from wave-to-wave. Dementia was defined using results from the Health and Retirement Study (HRS) global cognitive …

Marginal Warming Associated With A Covid-19 Quarantine And The Implications For Disease Transmission, P. W. Miller, C. Reesman, M. K. Grossman, S. A. Nelson, V. Liu, P. Wang

Faculty Publications

During January-February 2020, parts of China faced restricted mobility under COVID-19 quarantines, which have been associated with improved air quality. Because particulate pollutants scatter, diffuse, and absorb incoming solar radiation, a net negative radiative forcing, decreased air pollution can yield surface warming. As such, this study (1) documents the evolution of China's January-February 2020 air temperature and concurrent particulate changes; (2) determines the temperature response related to reduced particulates during the COVID-19 quarantine (C19Q); and (3) discusses the conceptual implications for temperature-dependent disease transmission. C19Q particulate evolution is monitored using satellite analyses, and concurrent temperature anomalies are diagnosed using surface …

Acceleration Of Boltzmann Collision Integral Calculation Using Machine Learning, Ian Holloway, Aihua W. Wood, Alexander Alekseenko

Faculty Publications

The Boltzmann equation is essential to the accurate modeling of rarefied gases. Unfortunately, traditional numerical solvers for this equation are too computationally expensive for many practical applications. With modern interest in hypersonic flight and plasma flows, to which the Boltzmann equation is relevant, there would be immediate value in an efficient simulation method. The collision integral component of the equation is the main contributor of the large complexity. A plethora of new mathematical and numerical approaches have been proposed in an effort to reduce the computational cost of solving the Boltzmann collision integral, yet it still remains prohibitively expensive for …

Dicer Represses The Interferon Response And The Double-Stranded Rna-Activated Protein Kinase Pathway In Mouse Embryonic Stem Cells, Chandan Gurung, Mona Fendereski, Krishna Sapkota, Jason Guo, Faqing Huang, Yan Lin Guo

Faculty Publications

Recent studies have demonstrated that embryonic stem cells (ESCs) are deficient in expressing type I interferons (IFN), the cytokines that play key roles in antiviral responses. However, the underlying molecular mechanisms and biological implications of this finding are poorly understood. In this study, we developed a synthetic RNA-based assay that can simultaneously assess multiple forms of antiviral responses. Dicer is an enzyme essential for RNA interference (RNAi), which is used as a major antiviral mechanism in invertebrates. RNAi activity is detected in wild-type ESCs but is abolished in Dicer knockout ESCs (D-/-ESCs) as expected. Surprisingly, D-/-ESCs have gained the ability …

A Radial Basis Function Finite Difference Scheme For The Benjamin–Ono Equation, Benjamin F. Akers, Tony Liu, Jonah A. Reeger

Faculty Publications

A radial basis function-finite differencing (RBF-FD) scheme was applied to the initial value problem of the Benjamin–Ono equation. The Benjamin–Ono equation has traveling wave solutions with algebraic decay and a nonlocal pseudo-differential operator, the Hilbert transform. When posed on ℝ, the former makes Fourier collocation a poor discretization choice; the latter is challenging for any local method. We develop an RBF-FD approximation of the Hilbert transform, and discuss the challenges of implementing this and other pseudo-differential operators on unstructured grids. Numerical examples, simulation costs, convergence rates, and generalizations of this method are all discussed.

Modeling And Simulation Techniques Used In High Strain Rate Projectile Impact, Derek G. Spear, Anthony N. Palazotto, Ryan A. Kemnitz

Faculty Publications

A series of computational models and simulations were conducted for determining the dynamic responses of a solid metal projectile impacting a target under a prescribed high strain rate loading scenario in three-dimensional space. The focus of this study was placed on two different modeling techniques within finite element analysis available in the Abaqus software suite. The first analysis technique relied heavily on more traditional Lagrangian analysis methods utilizing a fixed mesh, while still taking advantage of the finite difference integration present under the explicit analysis approach. A symmetry reduced model using the Lagrangian coordinate system was also developed for comparison …