Physical Sciences and Mathematics Commons^™

Analysis Of Dl-Amino Acid Ratios In Eggshells Using Reverse Phase-High Pressure Liquid Chromatography, Gergana Milkova

Honors Theses

HPLC methodology was developed to determine the concentrations and ratios of D to L amino acids in emu and ostrich eggshells treated with heat at different temperatures . We aimed to determine an internal standard and how ratios were affected under different conditions. An HPLC method was determined that gave consistent retention times and satisfactory enantioseparation . Calibration curves for each amino acid were developed from single and multi-amino acid containing dilution series producing a model that most closely replicates the eggshell-extracted amino acids.

Isolation And Characterization Of Novel Arginine-Derived Heterocyclic Amines, Nathaniel Srikureja

Honors Theses

Most known heterocyclic amines (HCAs) are potent mutagens present at significant concentrations in cooked meats, and can be synthesized from burned mixtures of L-creatin(in)e with various amino acids. We hypothesize that novel mutagenic HCAs may be synthesized from a heated plant-based food simulating binary amino acid mL'\:ture: L-arginine and L-threonine. A two-part solid phase extraction was used to separate nitrogen heterocycles from byproducts followed by prep­ HPLC and the Ames mutagenicity assay using Salmonella TA98 to determine the mutagenicity of various isolates. The results indicate that this binary amino acid mixture does not yield a mutagenic sample.

Synthesis Of An Ideal Inhibitor For The Lpxc Enzyme, Taejun Lee

Honors Theses

Due to the growing need of antibiotics in modern day medicine, this study attempts to apply a method of medicinal chemistry that would create a novel inhibitor for a lesser known target of gram negative bacteria, the LpxC enzyme. This study proposes that a synthetic plan which consists of combining components of different molecules would create a more effective inhibitor. These components include a binding group for the active site of the enzyme, a hydrophobic chain which has been shown to interact with an allosteric site on the LpxC enzyme, and the isoxazoline ring which interacts with the zinc ion. …

Exploring New Fe-Substituted Rare-Earth-Based High Entropy Alloys, Glendon Rewerts

Honors Theses

No abstract provided.

Accuracy Of Personalized 3-D Printed Phantoms For Radiotherapy Applications, Margaret Carey

Honors Theses

No abstract provided.

Salt Marsh Restoration In Louisiana: An Analysis Of Litter Decomposition, Joseph Winston

Honors Theses

No abstract provided.

Computer-Assisted Graphic Correlation Of Ordovician Conodonts And Graptolites From The Argentine Precordillera And Western Newfoundland Using Constrained Optimization (Conop9), Andrea Marie Bryan

Honors Theses

The correlation of rock units is the foundation of geological research. Correlation is the process of proving two geologic events are time equivalent. Most importantly, it is used to establish time boundaries in the geologic time scale. This paper uses computer assisted graphic correlation (CONOP9) to correlate the ages of graptolites and conodonts from the Ordovician found in rocks from the continent Laurentia, and arranges them in a composite range chart. These two organisms lived in different environments and, therefore, are found in different biofacies. The Argentine Precordillera and the western Newfoundland region are places where these two fossils co-exist …

Nitrate Contaminant Tracing In Surface And Groundwater In The Great Miami River Watershed: Environmental Isotope Approach, Rachel Kristine Buzeta

Honors Theses

The global population has increased exponentially causing several challenges surrounding sustainability, including greater food production needs. To meet these demands and boost agricultural productivity, more efficient practices and fertilizers are used. Synthetic fertilizers and other nutrient sources have resulted in water quality degradation and pollution. Much of the Great Miami River Watershed’s streams and aquifers in southwestern Ohio are affected by nitrate contaminants originating from anthropogenic sources including synthetic and organic fertilizer used for agriculture, human wastes (domestic, industrial, and municipal wastes), and urbanization. High nitrate concentrations cause ecological disturbances across all trophic levels. Nitrate levels greater than 10 mg/L …

The Number Of Fixed Points Of And-Or Networks With Chain Topology, Lauren Geiser

Honors Theses

Boolean networks are sets of Boolean functions, which are functions that contain Boolean variables and the logical operators AND, OR, and NOT. In the simple case, the variables can be in one of two states—either 1 or 0, which can be interpreted in different ways such as ON or OFF, or TRUE or FALSE, depending on the application. Arranging model systems into Boolean functions, we can study steady states of these networks. This refers to the overall state of the dynamical system given an initial condition and another theoretical condition such as a subsequent point in time. Boolean networks have …

Identifying Natural Inhibitors Of Bacterial Efflux Pumps, Marrisa Therriault

Honors Theses

Antibiotic resistance is a constantly progressing epidemic. Many strains of bacteria have developed a resistance to antibiotics, resulting in prolonged sickness and death. Resistance can be to a specific drug (single drug resistance) or to multiple drugs (multi-drug resistance). This resistance can be caused by a tripartite protein pump called an efflux pump that extends through the inner and outer membranes of the bacterium to pump antibiotics from the inside of the cell to the extracellular environment. In E. coli the efflux pump is called AcrAB-TolC. In the efforts to combat this problem, this experiment focuses on the inactivation of …

Character And Water Quality Of Sandpiper Pond: A Coastal Pond Assessment, Fifteen Years After Restoration, Nicholas E. Workman

Honors Theses

Sandpiper Pond is a coastal pond at Huntington Beach State Park, South Carolina. Originally a tidal inlet surrounded by marshland, it was isolated in 1989 and rechanneled in 2004-2005 under a community-based wetland restoration project. The project was designed to restore the pond to a tidal inlet to improve water quality and biodiversity. Since then, the tidal connection with the ocean has been severed once more and the main influx of seawater occurs from the marsh during spring high tides. In this three-month study, the current state of Sandpiper Pond is evaluated using fundamental biogeochemical indicators that are indicative of …

Tracking Disparate Colony Morphological Trends With Thermus Scotoductus, Matthew P. Leverick

Honors Theses

When plating most mesophilic bacteria, the colony shape, size, and color tends to be uniform when a single strain is present. When plating defined cell densities of T. scotoductus, however, the colonies were not of uniform size and shape while it grew on the surface. In this project, we sought to observe trends in colony morphology (shape and size) changes using the thermophile Thermus scotoductus on nutrient rich agar plates at 60°C. A general planktonic growth curve was also created to help characterize the activity of this bacterium. This project was our first attempt to characterize if this unusual phenomenon …

Boron Dipyrromethenes: Synthesis And Computational Analysis, Eduardo Rivé Lockwood

Honors Theses

Recently, there has been a growing interest in the boron dipyrromethene (BODIPY, 4,4′- difluoro-4-bora-3a,4a-diaza-s-indacene) compounds. BODIPY compounds have fascinating properties that allow for the absorption and emission of light in the near infrared region of the electromagnetic spectrum. These molecules are highly modifiable making them ideal chemicals for the use of photoelectric energy conversion such as for commercial use in dye sensitized solar cells (DSSCs). It has been previously shown that different meso compounds have only a slight effect on the absorptive capabilities of these BODIPY compounds. We believe that the BODIPY compounds’ lack of planarity is one of the …

Analysis And Review Of The Effects Of Bacterial Competition On Efflux Pump Inhibition, Robert Leszcynski

Honors Theses

Multidrug resistant antibacterial strains are a dangerous problem for modern medical professionals. When cells of two different strains are grown together, they must compete with each other for nutrients. This competition can lead to the production of harmful compounds that are toxic to the competing strain. One such compound may be a compound that inhibits the efflux of antibiotics from the cell. When the cells compete with one another, one or both of the cells will produce compounds that are harmful to the competing strain.

Topology Of Fractals, Amelia Pompilio

Honors Theses

No abstract provided.

Transitional Granulite-Facies Mafic Xenoliths In The 2.8 Ga Trondjhemite-Tonalite-Granodiorite (Ttg) Gneisses Of The Eastern Beartooth Mountains, Mt/Wy: Evidence For Variable Fluid Interactions, Andrew W. Osborne

Honors Theses

No abstract provided.

Analysis And Comparison Of Multiple Approaches For Software Development Management As Applied To A Design Studio Project, Bethany Hage

Honors Theses

This research analyzes multiple approaches to software development management through the lens of my experience in the Raikes Design Studio capstone program. The Design Studio project I participated in was a project for the company Hudl, and throughout its course we used techniques from the Agile framework of Scrum. I compared the Scrum principles to my team’s own application over the course of the project, and I researched other software development methodologies such as Extreme Programming and Lean in order to determine whether they could improve the effectiveness of the current Design Studio experience. The proposed solution to this question …

Dissolved Inorganic Nitrogen Dynamics In Swash Zone Sands Of Long Bay, Sc, Alexis F. Echols

Honors Theses

A key component affecting the biogeochemistry of the sedimentary environment is pore water between grains of sediments. Sedimentary microorganisms are constantly modifying chemical compounds as part of their life functions which are then exchanged between the sediment column and the overlying water column. Dissolved inorganic nitrogen, a major element for life, takes on several forms including nitrate, nitrite, and ammonium which vary in concentration throughout the sediment and with respect to each other. The relative concentrations of these nitrogen species have been previously briefly explored in sandy columns, where redox gradients that control their relative concentrations can be fairly deep …

Hinge Region In Dna Packaging Terminase Pul15 Of Herpes Simplex Virus: A Potential Allosteric Target For Antiviral Drugs, Lana Faisal Thaljeh

Honors Theses

No abstract provided.

Geophysical Analysis Of The Midcontinent Rift’S Subsurface Structure In Southeastern Nebraska, Patrick Szopinski

Honors Theses

The Midcontinent Rift System (MCRS) is a 1.1 billion-year-old failed rift system that spans much of the North American continental interior. The MCRS is exposed at Lake Superior and is buried in the subsurface along its southwest-extending arm through southeastern Nebraska. Due to the presence of buried volcanic rocks, the MCRS has characteristic highly-pronounced potential field anomalies (gravity and magnetic). Despite these large anomalies, not much is known about the subsurface faulting associated with the rift zone in the Midwest. The goal of this project is to attempt to use integrated analysis of collected geophysical data from multiple methods to …

Studies Of Boundary Layer Transition From Laminar To Turbulent, Elizabeth Spaulding

Honors Theses

In engineering applications, there is a strong desire to reduce energy losses due to turbulent energy production. However, the theoretical understanding of turbulent and transition flow is still lacking due to the absence of an exact mathematical solution for turbulent flow. In the current project, transition and turbulent behavior in wall-bounded flow is studied, with an emphasis on concepts from boundary layer theory. Organized structures, such as streaks, waves, and vortices, which occur in such flows, are analyzed. Especially for near-wall structures, control strategies for suppressing such structures are discussed. Using mathematical equations which govern fluid flow, models for different …

Pascal's Triangle Modulo N And Its Applications To Efficient Computation Of Binomial Coefficients, Zachary Warneke

Honors Theses

In this thesis, Pascal's Triangle modulo n will be explored for n prime and n a prime power. Using the results from the case when n is prime, a novel proof of Lucas' Theorem is given. Additionally, using both the results from the exploration of Pascal's Triangle here, as well as previous results, an efficient algorithm for computation of binomial coefficients modulo n (a choose b mod n) is described, and its time complexity is analyzed and compared to naive methods. In particular, the efficient algorithm runs in O(n log(a)) time (as opposed to …

The Effect Of Invasive Aquatic Vegetation On Odonate Diversity In An Urban Area, Sarah Thomas

Honors Theses

No abstract provided.

Assessing Knowledge Of Coastal Land Loss In Louisiana High School Graduates, Madelyn Smith

Honors Theses

No abstract provided.

Peerra: An Extensible And Structured Web Service For Peer-To-Peer Assistance, Drake Lambert

Honors Theses

No abstract provided.

Ordered Growth Of Ferroelectric Diisopropylammonium-Bromide Microcrystals Through Slotted-Jar Growth And Lithographically Controlled Wetting, Andrew J. Fanning

Honors Theses

Organic molecular ferroelectrics show promise for industry applications because of their switchable high spontaneous polarization value, mechanical flexibility, and cost-effectiveness. Since these materials, namely diisopropylammonium bromide, exhibit ferroelectricity only in tandem with a high level of crystallinity, novel methods must be explored in order to ensure that high levels of crystallinity are achieved. This project seeked to perfect the methods of Slotted Jar Growth and Lithographically Controlled Wetting (LCW). Slotted Jar Growth uses temperature driven solution saturation to grow crystals on a desired substrate. LCW drives the growth of microscopic diisopropylammonium bromide crystals, in their ferroelectric phase, through the use …

Determining The Presence Of Bpa In Vaping Mouthpieces, Jessica Cook-Snelgrove

Honors Theses

As more and more teenagers and young adults begin to vape, whether it be to quit smoking or to look cool, there is a potential for them to be exposed to bisphenol-A (BPA) through the plastic mouthpieces on the vapes. BPA is a molecule that is added in many plastics to make the plastic harder (Houlihan, Lunder, & Jacob, 2008). Unfortunately, BPA is structurally similar to estrogen as can be seen in Figure 1. The closeness of the structures can cause issues in humans such as cardiovascular disease, diabetes, and reproductive problems (Houlihan, Lunder, & Jacob, 2008). In recent years, …

Shape Memory Alloy Applications, Dillon Wester

Honors Theses

Shape memory alloys (SMAs) are unique mixtures of metals that have qualities unlike any other substance. Most notably is their ability to "remember" a shape and revert back to that shape with the application of heat. One such alloy is the Ni-Ti alloy, Nitinol. SMAs also have many other favorable characteristics such as superelasticity, biocompatibility and much more. Superelasticity is the ability to bend under stress and then return to its original shape with the removal of the stressor. Biocompatibility means that the SMAs are not toxic to living organisms, whether they are only used periodically or left in permanently. …

Evaluating The Iron Geochemistry Of Terrestrial Aerosol Sources To The Subarctic Pacific Ocean, Meg Yoder

Honors Theses

Wind-blown dust and volcanic ash deposited in high nutrient, low chlorophyll (HNLC) regions can fertilize phytoplankton by providing iron and other trace nutrients, in turn impacting ecosystems as well as the global carbon and nitrogen cycles. The second largest HNLC region in the world is the northeastern subarctic Pacific. Aeolian transport to this region deposits lithogenic material including desert-derived dust from Asia, glacier-derived dust from Alaska and northwestern Canada, and volcanic ash from Eurasia and North America.

This research aims to assess the geochemistry of aerosol sources to the northeastern subarctic Pacific in relation to the biological availability of iron. …

Biodiversity And Distribution Of Benthic Foraminifera In Harrington Sound, Bermuda: The Effects Of Physical And Geochemical Factors On Dominant Taxa, Nam Le

Honors Theses

Harrington Sound, Bermuda, is a nearly enclosed lagoon acting as a subtropical/tropical, carbonate-rich basin in which carbonate sediments, reef patches, and carbonate-producing organisms accumulate. Here, one of the most important calcareous groups is the Foraminifera. Analyses of common benthic orders, including miliolids (Quinqueloculina and Triloculina spp.) and rotaliids (Homotrema rubrum, Elphidium spp., and Ammonia beccarii), are essential in understanding past and present environmental conditions affecting the island's coastal environment. These taxa have been studied previously; however, factors explaining their individual patterns of abundance in the Sound are not well detailed. The goal of this study is …