Physical Sciences and Mathematics Commons^™

Annealing 2-Decanol In Nano-Confined Systems: Effects Of Annealing Time, Caleb Novins

Honors Theses

We studied melting and freezing of 2-decanol nano-crystals (100 Angstrom to 1000 Angstrom) using a Differential Scanning Calorimeter (DSC). In agreement with the Gibbs-Thompson equation, the melting temperature of nano crystals decreases with physical size and its change scales linearly with the inverse of physical size. The apparent heat of fusion of the nano scaled systems, however, has been found to be lower than the heat of fusion for the bulk. Although this is in agreement with previous experimental observations, it is in contradiction with the assumptions used to develop the Gibbs-Thompson equation. We believe that the apparent heat of …

Blooming Lotus, Brian Nguyen

Honors Theses

While reflecting on my poetry chapbook, Blooming Lotus, I ask myself what I was trying to accomplish by creating the chapbook. I have always been interested in my East Asian culture, but growing up as an Asian American has resulted in some ignorance in regards to the topic. I wanted to explore more of my own heritage through the creation of this chapbook by writing poems inspired by East Asian culture. Not only did I want to expose myself to East Asian culture but I also wanted to expose my readers to it as well. Most of my poems required …

Encoding Knots, Rachael Keller

Honors Theses

No abstract provided.

Visualization And Analysis Of Wikipedia Data Relating To Louisiana And Its Culture, Morgan Hargrove

Honors Theses

No abstract provided.

Modeling Deformations Of Solids At The Continuum Scale, Paxton Turner

Honors Theses

No abstract provided.

Determination Of Antibiotic Release From Electrospun Nanofibers, John P. O'Brien Iii

Honors Theses

Decreasing the risk of infection following surgery for traumatic bone breaks is a major focus of the medical and scientific community. Drug delivery devices are emerging as powerful solutions for combating infection following these procedures. Current devices, however, suffer several drawbacks including poor antibiotic release rate and control the devices themselves not being biodegradable. This thesis studies the \textit{in vitro} release rate for antibiotics tobramycin and vancomycin from a biodegradable medical implant. Antibiotics, collagen, and bone growth factors are incorporated into Poly(lactide-co-glycolide)-based electrospun nanofibers by local company eSpin for development. The drug-loaded nanofibers are immersed in phosphate buffered saline (PBS) …

Synthesis Of Novel Dienes And Cyclic Compounds Via Olefin Metathesis Reactions Catalyzed By The Second Generation Grubbs Catalyst, Patrick Joseph Carey

Honors Theses

Transition metal-catalyzed olefin metathesis reactions play a significant role in chemical synthesis. These reactions are currently applied across several disciplines, and their full potential has not yet been reached. This project details the synthesis of spiro[3-cyclopentene-1,9’-[9H]fluorene], 1-(1-amino-2-methylpropyl)-3-cyclopentenol, and the eugenol dimer via olefin metathesis reactions catalyzed by the second generation Grubbs catalyst. The unique structural properties of each compound help demonstrate the widespread abilities of these reactions. Also reported are the novel three-dimensional crystal structures of both spiro[3-cyclopentene-1,9’-[9H]fluorene] and the eugenol dimer. These structures were determined via X-ray diffraction crystallography methods using a Bruker SMART X2S Single Crystal Diffractometer. Both …

Investigation Of The Thermodynamic Properties Of The Oligomerization Domain Of Heterogeneous Nuclear Ribonucleoprotein C, John P. O'Brien Iii

Honors Theses

The heterogeneous nuclear ribonucleoprotein C (hnRNP C) performs a critical role in the processing of nascent pre-messenger ribonucleic acid (pre-mRNA) transcripts as they exit DNA polymerase II. As the pre-mRNA transcripts emerge from the polymerase complex, they are bound by hnRNP C only if its nucleotide (NT) chain is longer than a certain nucleotide length. If the chain is long enough and binding occurs, the nucleotide strand is exported and processed as mRNA, whereas if the length requirement is not met, the RNA sequence is directed along a pathway to become small nuclear RNA (snRNA). The functional form of hnRNP …

Modifications Of Lysozyme By Substituted Benzoquinones, Hendrik J. Greve

Honors Theses

Amyloidosis, which involves the precipitation of mis-folded protein aggregates, is a prominent process that occurs in many neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease; the protein aggregates being amyloid-β for Alzheimer’s disease and α-synuclein for Parkinson’s disease. This study has focused on lysozyme modifications induced by metabolites of the commonly found pollutants known as polycyclic aromatic hydrocarbons (PAHs). PAHs are found in substances ranging from grilled meats to cigarette smoke to cosmetics, and they can be metabolized into a family of biological toxins known as benzoquinones. The molecules of interest for this study were 1,4-benzoquinone (pBQ), 2-chloro-1,4-benzoquinone (CBQ), …

Ribonuclease A Modification Induced By 1,2-Naphthoquinone And 2-Hydroxy-1,4-Naphthoquinone, Michelle Dawn Smith

Honors Theses

Protein modifications may occur upon exposure to environmental toxins such as polycyclic aromatic hydrocarbon (PAH) molecules or their metabolites. In this context, our laboratory was interested in investigating protein modifications in the presence of select naphthoquinones, which were 2-hydroxy-1,4-naphthoquinone (HNQ) and 1,2-naphthoquinone (o-NQ). The effects of HNQ and o-NQ on the protein Ribonuclease A (RNase) were investigated through a variety of conditions. These modified incubation conditions included pH variation and the addition of metal ions to further mimic physiological conditions. Documentation of results was carried out through sodium dodecyl sulfate polyacrylamide gel electrophoretic analysis (SDS-PAGE). Of the two quinones, o-NQ …

Matrix Exponentiation Without Scaling And Squaring, Bruno Gabriel Beltran

Honors Theses

No abstract provided.

Procedural Content Generation: Using A.I. To Generate Playable Content, Osler Kendall Moore Jr.

Honors Theses

This thesis is about using Artificial Intelligence in regards to Procedural Content Generation to help try and avoid a deadlock scenario in a hypothetical dungeon exploring game. The deadlock scenario is essentially having a key being placed in a room that’s inaccessible to the player. An example of such a scenario would be if the key to room A being in Room B, the key to room B was in room A, and the player was in room C. The program generates the dungeon world with a random number of rooms inside it, each room also having a random number …

Biomimetic Adhesive Thiol-Ene Films For Improved Adhesion, Laken L. Kendrick

Honors Theses

Current dental restoration materials fall short in adhesion and often pull away from the surface of the tooth upon curing. This project seeks to design polymers that can adhere to wet, heterogeneous surfaces as potential materials for dental restoration applications. The goal of this project is to mimic the structure and adhesive properties of natural adhesives containing 3,4-dihydroxyphenyl-L-alanine (DOPA). We will synthesize mono- and di-functional DOPA derivatives with catechol functionality and investigate their adhesion compared to their non-catechol-containing alternative through incorporation into a model thiol-ene photopolymerization. Functional group conversion, real time kinetics, and adhesion data will be used to analyze …

2-Domination And Annihilation Numbers, Sean C. Patterson

Honors Theses

Using information provided by Ryan Pepper and Ermelinda DeLaVina in their paper On the 2-Domination number and Annihilation Number, I developed a new bound on the 2- domination number of trees. An original bound, γ₂(G) ≤ (n+n₁)/ 2 , had been shown by many other authors. Our goal was to generate a tighter bound in some cases and work towards generating a more general bound on the 2-domination number for all graphs. Throughout the span of this project I generated and proved the bound γ₂(T ) ≤ …

Relativistic And Non-Relativistic Proton-Nucleus Scattering, Kinsey Ann Elisabeth Zarske-Williamson

Honors Theses

Calculations for proton-nucleus scattering often rely on transition amplitudes. We implement new transition amplitudes [7] with the relativistic equations. We can find the matrix elements of the operators between the usual Dirac spinor basis or the helicity spinor basis. The operators can also be written as a linear combination of non-relativistic spin operators. To transform from one basis to another, we need to find a transformation matrix. We must establish what one of the factors that appears in the transformed expression means in order to correctly complete our transformation matrix. Once this is resolved, our transformation matrix will be complete.

Analysis Of The Mechanical Properties Of Dgebf/4,4’-Dds Thermoset Systems As A Function Of Cure Rate, Chase B. Thompson

Honors Theses

The relationship between macroscopic mechanical and thermal properties and ramp rate during cure of epoxy-amine systems consisting of the epoxide resin digylcidyl ether of bisphenol F (DGEBF, provided Hexion specialty chemicals) and 4,4-diaminodiphenyl sulfone (4,4-DDS, provided by Atul Sulpho) were probed using Dynamic Mechanical Analysis (DMA), Positron Annihilation Lifetime Spectroscopy (PALS), and compression testing. These systems were cured in a programmable oven; the samples were heated from 35°C to 180°C at ramp rates of 0.5, 1.0, 1.5, 2.0, 2.5, 5.0, 10, and 15°C/min. Even as the ramp rates during the cure of these materials was changed, there was very little …

Modeling The Diffusion Of Heat Energy Within Composites Of Homogeneous Materials Using The Uncertainty Principle, Elyse M. Garon

Honors Theses

The purpose of this project is to model the diffusion of heat energy in one space dimension, such as within a rod, in the case where the heat flow is through a medium consisting of two or more homogeneous materials. The challenge of creating such a mathematical model is that the diffusivity will be represented using a piecewise constant function, because the diffusivity changes based on the material. The resulting model cannot be solved using analytical methods, and is impractical to solve using existing numerical methods, thus necessitating a novel approach.

The approach presented in this thesis is to represent …

The Effects Of Recreational Rock Climbing On Vascular And Nonvascular Plant Communities In Southeastern Tennessee, Caitlin A. Ruby

Honors Theses

Popularity for non-consumptive outdoor recreations has rapidly increased over the past decades. With many national and state park regulations failing to regulate rock climbing, scholars are concerned for the amount of ecological disturbance that may occur if left unmonitored. Visual assessments to disturbance disparities between remote climbing locales and contradictory scientific literature confirmed the need for further research on the effects of rock climbing on cliff ecology. Two climbing centers were focused in Southeastern Tennessee: Foster Falls in Sequatchie County and Leda in Hamilton County. Convenience sampling was used to collect 24 transects from intermediately graded routes and 24 transects …

Polymerization Of Blocked Isocyanate Functional Polymer Surfaces And Post-Polymerization Modification By Thiol-Isocyanate Reactions, Chase A. Tretbar

Honors Theses

Direct polymerization of isocyanate-functional monomers has been achieved with controlled radical polymerizations (CRP) for precisely engineered modification platforms with highly reactive side chains. However, despite the success of these strategies, the inherent reactivity of isocyanates still leads to adverse side reactions, such as hydrolysis, that are difficult to suppress. Phenol, lactam, and oxime-based blocking agents have been used to limit the reactivity of isocyanates in applications such as multicomponent urethane coating systems. The reactivity of these blocked isocyanates can be restored by thermal deprotection of the blocking agent to achieve the desired reactions. In this work, we use blocked isocyanate-functional …

Deposition And Characteristics Of West Bay Sediment In The Mississippi River Delta, And The Effects Of Polymers On Sediment Erodibility, Patrick Robichaux

Honors Theses

No abstract provided.

Local Response To Climate Change: A Case Study Approach, Nora Gimpel

Honors Theses

The scientific consensus on the causes and consequences of climate change is clear and experts continue to strongly recommend immediate mitigation and adaptation responses (IPCC, 2014). Responses to climate change are occurring at the international, national, and subnational level, but adaptation to climate change is also highly local. Local communities across the world are organizing groups and institutions to determine their best responses for local mitigation and adaptation actions. This study analyzed the formal local community organization, the Kalamazoo Climate Change Coalition (KCCC), and its structured activities in order to evaluate how Kalamazoo has responded to climate change. Methodology for …

Influence Of Road Salt Deicers On Anaerobic Respiration And Metal Speciation In Soils, Danielle Dupuis

Honors Theses

Road salt deicers, especially NaCl and CaCl₂, are used throughout the world on paved areas during the winter. Previous studies suggest that road salt deicers can alter the biogeochemistry of sediment located near roadways and influence the mobility of heavy metals. The goal of this study is to investigate the influence of CaCl₂ on wetland soil biogeochemistry, especially trace metal speciation. Sediment cores were collected in the fall from a freshwater wetland near an urban kettle lake (Asylum Lake, Kalamazoo, MI) and incubated for 100 days in deionized water (control), 5 g/L of CaCl₂, or …

Medicare: Program, Procedures And Recommendations, Sarah Wyman

Honors Theses

My thesis is formatted in the style of a political brief, based upon the program Medicare. This report discusses the question of whether the Medicare program is performing effectively. It discusses the origins and development of Medicare, its mission and reason for the program. Included is the staffing of the Centers for Medicare and Medicaid Services, a center within the Department of Health and Human Services. It discusses the historical, current, and projected funding through FY 2015. Most notably it contains the program performance ratings of Medicare from the White House, CBO, OMB, and CMS. Medicare is a program that …

Synthesis Of Phosphorus-Based Hemiacetals For Potential Flame Retardants, Sara Alakkad

Honors Theses

Flame retardants which contain a phosphorus moiety attached to a carbohydrate backbone were developed. To synthesize the flame retardants, carbohydrates and polyols were used as the starting materials which occur in nature and are environmentally and toxicologically safe materials. The two target structures include one with a triose substructure and one with a pentose substructure. For both situations, however, multiple steps were taken for the synthesis of the flame retardant, as the carbohydrate needed to be generated into its protected form. The protected carbohydrate then interacted with a dialkyl phosphite, resulting in a phosphorous hemiacetal. This hemiacetal was then deprotected …

Distributed Augmented Reality Communications And Interactions, Mitchell Mason

Honors Theses

No abstract provided.

Geometrical Phases On The Poincaré And Bloch Spheres, Jason D. Mueller

Honors Theses

No abstract provided.

Development Of Inexpensive Educational Robotics Tools, Brandon Oubre

Honors Theses

No abstract provided.

Assessing The Impacts Of Nutrient Load Reduction Scenarios On The Extent And Severity Of Hypoxia In The Northern Gulf Of Mexico, David Fertitta

Honors Theses

No abstract provided.

Exploration Of Protein-Protein Interactions Involving Deinococcus Radiodurans Pria, Dnab And Ssb, Christopher S. Morrow

Honors Theses

Deinococcus radiodurans is a species of bacteria that has sparked a lot of interest since its discovery due to its incredible resistance to ionizing radiation. When exposed to ionizing radiation the genome of D. radiodurans will sustain over one hundred double stranded breaks. D. radiodurans demonstrates the ability to repair its genome and restart replication after sustaining, typically lethal, DNA damage. This project examined the mechanism of replication restart in D. radiodurans by investigating primosome protein PriA interacting with replicative helicase DnaB and single stranded binding protein. Many different types of gel electrophoresis were employed to investigate potential protein complex …

Synthesis Of Potential Phosphorus-Nitrogen Containing Flame Retardants, Colin Kloock

Honors Theses

Production of extremely efficient flame retardants is ideal because, in many instances, the amount of flame retardants that are added to pre-production to the mixture are so large that they can have an effect on the physical properties of the material. In addition, these types of polymers, when added during production, are homogenously mixed throughout the mixture which means not only uniform distribution and therefore function, but a less concentration of the retardants need to be used. Using Phosphorus-Nitrogen containing flame retardants in mixtures can have two means by which they function. First is the ability of P-N compounds to …