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Full-Text Articles in Physical Sciences and Mathematics
A Theoretical Investigation On The Activation Of Small Molecules By A Disilenide: A Dft Prediction, Cem Burak Yildiz, Akin Azi̇zoğlu
A Theoretical Investigation On The Activation Of Small Molecules By A Disilenide: A Dft Prediction, Cem Burak Yildiz, Akin Azi̇zoğlu
Turkish Journal of Chemistry
Herein, we proposed several mechanistic scenarios for activation of small molecules (NH$_{3}$, CO$_{2}$, CS$_{2}$, H$_{2}$, CH$_{4}$, N$_{2}$, and N$_{2}$O) by a disilicon analogue of a vinyl anion (1H) using density functional theory (DFT) calculations. The DFT results established that all the possible reactions to yield a variety of potential products have an exergonic nature except for the activation of N$_{2}$ with the obtained overall energy of $\Delta $G = 33.6 kcal mol$^{-1}$. Moreover, the highest exergonic character was $\Delta $G = $-$95.8 kcal mol$^{-1}$ for N$_{2}$O. Therefore, the findings reveal that 1H can be considered a suitable candidate for activation …
Enhanced Uptake Capacities And Isosteric Heats Of Co$_{2}$ And Ch$_{4}$ Adsorption On Spent Coffee Ground Activated Carbons Loaded With Metal Ions, Çi̇sem Kirbiyik, Burak Zafer Büyükbekar, Mahmut Kuş, Mustafa Ersöz
Enhanced Uptake Capacities And Isosteric Heats Of Co$_{2}$ And Ch$_{4}$ Adsorption On Spent Coffee Ground Activated Carbons Loaded With Metal Ions, Çi̇sem Kirbiyik, Burak Zafer Büyükbekar, Mahmut Kuş, Mustafa Ersöz
Turkish Journal of Chemistry
Low-cost activated carbon (AC) samples obtained from waste coffee grounds were used for CO$_{2}$ and CH$_{4}$ adsorption. ACs were prepared by chemical activation and carbonized at three different temperatures. AC carbonized at 800 $^{\circ}$C showed a relatively high surface area (582.92 m$^{2}$ g$^{-1})$ and high adsorption capacities of 2.6 mmol g$^{-1}$ and 1.1 mmol g$^{-1}$ at 25 $^{\circ}$C for CO$_{2}$ and CH$_{4}$, respectively. Adsorbent samples were prepared by loading of Fe$^{3+}$ metal ions onto ACs and their adsorption capacities were compared with those of nonloaded ACs. As expected, the loading of Fe$^{3+}$ metal ions increased the adsorption capacities at all …
Bisbenzoxazole Derivatives Had An Antiinflammatory Effect On In Vitro Stimulated Macrophages, Furkan Ayaz, Rusmeenee Kheeree, Qadar Ahmed Isse, Ronak Haj Ersan, Özteki̇n Algül
Bisbenzoxazole Derivatives Had An Antiinflammatory Effect On In Vitro Stimulated Macrophages, Furkan Ayaz, Rusmeenee Kheeree, Qadar Ahmed Isse, Ronak Haj Ersan, Özteki̇n Algül
Turkish Journal of Chemistry
Benzoxazoles are DNA base bioisosteres and studies suggest that their derivatives have antiproliferative activities. Based on their antiproliferative activities they have been mostly studied as new generation anticancer drugs. In our study we exploited their antiproliferative effect, aiming to delineate bisbenzoxazole derivatives' (RHE 231 and RHE 238) potential antiinflammatory effect on mouse macrophages that are activated in vitro through danger signal LPS stimulation. RAW 267.4 mammalian macrophages were activated in the presence of our derivatives with or without danger mimic E. coli derived LPS. We present data that support the strong antiinflammatory activity of the bisbenzoxazole derivatives RHE 231 and …
Sensitive Biological Detection Based On Langmuir--Blodgett Films Prepared From Diluted Silica Suspensions, Numan Gözübenli̇
Sensitive Biological Detection Based On Langmuir--Blodgett Films Prepared From Diluted Silica Suspensions, Numan Gözübenli̇
Turkish Journal of Chemistry
Self-assembled three-dimensional (3-D) colloidal crystals have been extensively utilized in nanolithography for fabricating a wide spectrum of functional periodic nanostructures for important technological applications. Here a simple and versatile way is reported using silica colloids to prepare close-packed particle multilayers by the Langmuir--Blodgett technique to create highly ordered 3-D colloidal crystals with unusual nanoarrays on a large variety of substrates. Successive deposition of monolayers using amphiphilic molecules in this approach allows control of the layer thickness, particle size, and especially packing structure of them in each layer. It has been demonstrated that the Langmuir--Blodgett film's transparency and high antiglare optical …
Hydrogen Storage In Formic Acid As A Renewable Energy Source Using Heterogeneous Catalysis, Obaid Aldosari
Hydrogen Storage In Formic Acid As A Renewable Energy Source Using Heterogeneous Catalysis, Obaid Aldosari
Turkish Journal of Chemistry
One of the most vital chemicals, which is not only found naturally but can also be synthesized in the laboratory, is formic acid (FA). FA is a key byproduct of several second-generation biorefinery processes as well, and it is used in several pharmaceutical and industrial applications. Recently, another significant use of FA that is taking the lead is as a form of fuel. This could either involve reformation, as a possible form of chemical hydrogen storage, or be done without reformation in the form of FA fuel cells, in particular because FA fuel cells are much more effective than other …
Synthesis And Spectroscopic Characterization Of New Phthalocyanine Derivatives: Application As Photocatalysts For The Degradation Of Orange G, Yusuf Yilmaz, Kayode Sanusi
Synthesis And Spectroscopic Characterization Of New Phthalocyanine Derivatives: Application As Photocatalysts For The Degradation Of Orange G, Yusuf Yilmaz, Kayode Sanusi
Turkish Journal of Chemistry
New derivatives of 2(3),9(10),16(17),23(24)-tetrakis-(6-methylpyridin-2-yloxy)phthalocyanine (Pc) (2b, 2c, and 2d) were synthesized and their structures were characterized by elemental analysis, IR, $^{1}$H NMR, and high-resolution mass spectrometry. The spectral results were in line with the proposed structures. The photodegradation of Orange G (OG) dye in DMSO by the Pc derivatives was investigated. The compounds showed relatively high photodegradation rates that increased with increasing size of the central atoms. The Pc photodegradation rates showed fair correlation with the singlet oxygen generation efficiencies (${\Phi }_{{\Delta }})$. The observed rate constants were higher than the values already reported for other Pcs in the literature …
Peripherally 1,2-Dinaphthyl Ethanediol Substituted Phthalocyanine Complexes: Synthesis, Characterization, Aggregation, And Application In Benzyl Alcohol Oxidation At Room Temperature, Hali̇l Zeki̇ Gök, Mustafa Kemal Yilmaz
Peripherally 1,2-Dinaphthyl Ethanediol Substituted Phthalocyanine Complexes: Synthesis, Characterization, Aggregation, And Application In Benzyl Alcohol Oxidation At Room Temperature, Hali̇l Zeki̇ Gök, Mustafa Kemal Yilmaz
Turkish Journal of Chemistry
In this study, the synthesis of a novel 1,2-dinaphthyl ethanediol substituted phthalonitrile (2) together with tetra-substituted zinc(II) phthalocyanine (Pc) (3) and cobalt(II) Pc (4) bearing 1,2-dinaphthyl ethanediol at peripheral positions was described. The aggregation behaviors of metallophthalocyanines 3and 4 in solution were investigated by carrying out Beer-Lambert experiments at different concentrations. In addition, the catalytic activity of new cobalt(II) Pc 4 was investigated for benzyl alcohol oxidation. Benzyl alcohol was converted to benzaldehyde using cobalt(II) Pc 4 as a catalyst by a conversion of 99% with selectivity of 100% at room temperature in 1 h. Several spectroscopic techniques such as …
Antioxidant Properties Of Water-Soluble Phthalocyanines Containing Quinoline 5-Sulfonic Acid Groups, Armağan Günsel, Esma Hande Alici, Ahmet Turgut Bi̇lgi̇çli̇, Gülnur Arabaci, Meryem Ni̇lüfer Yaraşir
Antioxidant Properties Of Water-Soluble Phthalocyanines Containing Quinoline 5-Sulfonic Acid Groups, Armağan Günsel, Esma Hande Alici, Ahmet Turgut Bi̇lgi̇çli̇, Gülnur Arabaci, Meryem Ni̇lüfer Yaraşir
Turkish Journal of Chemistry
In the present study, the antioxidant properties of peripherally and nonperipherally water-soluble tetra (quinoline 5-sulfonic acid) substituted metal-free (1,2), Zn(II) (3, 4), Co(II) (5, 6), and Mn(III)Cl (7, 8) phthalocyanine (Pc) derivatives were reported. In order to determine the antioxidant properties of the Pc compounds, three different commonly known antioxidant methods were used: DPPH ($\alpha $,$\alpha $-diphenyl-$\beta $-picrylhydrazyl) radical scavenging, ferrous ion chelating, and reducing power assays. Compound \textbf{6} showed the best DPPH activity among the other tested compounds except for the standards. The ferrous ion chelating IC$_{50\, }$value of compound 7 was nearly as good as that of the …
Targeting Human Telomeric Dna With Azacyanines, Ayça Küçükakdağ Doğu, Özgül Persi̇l Çeti̇nkol
Targeting Human Telomeric Dna With Azacyanines, Ayça Küçükakdağ Doğu, Özgül Persi̇l Çeti̇nkol
Turkish Journal of Chemistry
Small molecules targeting telomeric DNA or its interactions with telomerase have been an active area of cancer research. In the present study, we investigated the interactions of six benzimidazole compounds, called azacyanines, differing from each other in alkyl chain length and branching in the benzimidazole ring (azamethyl, azaethyl, azapropyl, azaisopropyl, azabutyl, and azaisobutyl) with human telomeric DNA (tel24) in 1:1 and 1:6 ratio (tel24:azacyanine) using UV-Vis, circular dichroism (CD), and fluorescence spectroscopy. All the compounds were binding to tel24 as indicated by the formation of the weak induced CD band between 320 nm and 360 nm. A substantial red shift …
Optical Characterization Of Salt-Induced Swelling Behavior Of Poly($N$-Isopropylacrylamide) Terpolymer Hydrogel Layers, İlke Anaç, Anil Bozdoğan
Optical Characterization Of Salt-Induced Swelling Behavior Of Poly($N$-Isopropylacrylamide) Terpolymer Hydrogel Layers, İlke Anaç, Anil Bozdoğan
Turkish Journal of Chemistry
This study reports for the first time the effect of different sodium halide salts (NaClO$_{4}$, NaI, and Na$_{2}$CO$_{3})$ in the low concentration range (in the range of 10$^{-7}$-1 M) on the swelling behavior of photo-crosslinked, surface-immobilized poly($N$-isopropyl acrylamide) (PNIPAAm) terpolymer layers. PNIPAAm terpolymer (consisting of $N$-isopropylacrylamide, methacrylic acid, and 4-methacryloxybenzophenone) was synthesized via free radical polymerization. The PNIPAAm terpolymer layers were prepared on gold substrates via spin coating and crosslinked and surface attached via UV radiation. The swelling behavior of the layers in monovalent (NaClO$_{4}$ and NaI) and divalent (Na$_{2}$CO$_{3})$ solutions was monitored by surface plasmon/optical waveguide spectroscopy. The terpolymer …
Amperometric Urea Biosensor Based On Immobilized Urease On Polypyrrole And Macroporous Polypyrrole Modified Pt Electrode, Maliheh Hosseinian, Ghasem Najafpour, Ahmad Rahimpour
Amperometric Urea Biosensor Based On Immobilized Urease On Polypyrrole And Macroporous Polypyrrole Modified Pt Electrode, Maliheh Hosseinian, Ghasem Najafpour, Ahmad Rahimpour
Turkish Journal of Chemistry
Biosensing of urea by a biosensor as a direct detection method at ambient temperature and pressure instead of chromatography leads to a significant reduction in processing costs. Amperometric biosensors based on urease immobilization on macroporous polypyrrole (MPPy) and pyrrole on the surface of a Pt electrode were developed. Applying cyclic voltammetry (CV), we demonstrated the synthesis of MPPy using monodispersed polystyrene spheres (460 nm) as a template. CV and chronoamperometric studies were conducted to evaluate the electrochemical current of the modified electrodes. For the electrode with polypyrrole (PPy), the biosensor response was linear in the range of 1.67--8.32 mM (R$^{2}$ …
Coumarin-Based Benzilmonohydrazone As A New Proton-Sensitive Fluorescence Dye: Synthesis And Investigation Of Photophysical And Acidochromic Properties, Burcu Aydiner
Turkish Journal of Chemistry
Coumarin-based chromogenic and fluorogenic dye 4 was designed and synthesized. The photophysical properties of 4 were determined in solvents with different polarities. Protonation affinity was determined by adding trifluoroacetic acid (TFA) to a dichloromethane solution of dye 4 utilizing the UV-Vis and fluorescence titration methods. The protonation region was investigated by using the $^{1}$H NMR method. Additionally, DFT and TDDFT studies were performed to support the structural and absorption spectral properties of 4.
Detection Of Lard Contamination In Five Different Edible Oils By Ft-Ir Spectroscopy Using A Partial Least Squares Calibration Model, Fazeelah Munir, Syed Ghulam Musharraf, Syed Tufail Hussain Sherazi, Muhammad Imran Malik, Muhmmad Iqbal Bhanger
Detection Of Lard Contamination In Five Different Edible Oils By Ft-Ir Spectroscopy Using A Partial Least Squares Calibration Model, Fazeelah Munir, Syed Ghulam Musharraf, Syed Tufail Hussain Sherazi, Muhammad Imran Malik, Muhmmad Iqbal Bhanger
Turkish Journal of Chemistry
Lard is defined as animal fat acquired from the adipose tissue of pigs and is not permitted for human consumption or external use by certain religions such as Islam and Judaism. Due to its low-cost availability for commercial use, it is often mixed with other vegetable oils mistakenly or deliberately and causes loss of consumer trust; hence, its detection in food products is essential. Consumers tend to know the authenticity of commercially available edible oils. However, edible oils are subjected to adulteration risks with lard, which breaches consumer rights. In the present study, we designed a transmission Fourier transform infrared …
Novel Voltammetric Investigation Of Dipyridamole At A Disposable Pencil Graphite Electrode, Iulia Gabriela David, Lorelei Iordache, Dana Elena Popa, Mihaela Buleandra, Victor David, Emilia-Elena Iorgulescu
Novel Voltammetric Investigation Of Dipyridamole At A Disposable Pencil Graphite Electrode, Iulia Gabriela David, Lorelei Iordache, Dana Elena Popa, Mihaela Buleandra, Victor David, Emilia-Elena Iorgulescu
Turkish Journal of Chemistry
The present paper describes the voltammetric analysis of dipyridamole (DIP) at a cheap, disposable pencil graphite electrode (PGE). The working conditions were optimized with regard to the electrode material and the supporting electrolyte. Cyclic voltammetric investigations emphasized that DIP is irreversibly oxidized at the PGE. The electrode process is pH-dependent and controlled by both diffusion and adsorption. For DIP quantitative determination a differential pulse voltammetric (DPV) method in phosphate buffer solution pH 7.00 was developed. DIP's oxidation peak current varied linearly with the analyte concentration, presenting two linear ranges, namely 5.00 $\times $ 10$^{-7}$-2.50 $\times $ 10$^{-5}$ M and 2.50 …
$N$-Acylazole Mediated Stereoselective And Regioselective Synthesis Of $N$-Substituted Azole Acrylonitriles, Osman Aydin, Şule Kökten, Hakan Ünver, İlhami̇ Çeli̇k
$N$-Acylazole Mediated Stereoselective And Regioselective Synthesis Of $N$-Substituted Azole Acrylonitriles, Osman Aydin, Şule Kökten, Hakan Ünver, İlhami̇ Çeli̇k
Turkish Journal of Chemistry
Regio- and stereoselective synthesis of $N$-substituted azole acrylonitriles has been achieved smoothly in $N,N$-dimethylformamide (DMF) in the presence of potassium carbonate (K$_{2}$CO$_{3})$ as a base catalyst. $N$-Substituted azole acrylonitriles were obtained in moderate to good yields (39%-87%) with a one-pot reaction between readily available $N$-acetylazoles and Baylis-Hillman nitriles. The structural determinations were accomplished by NOESY $^{1}$H NMR and X-ray crystallography.
Molecular Dynamics Simulations Of Adsorption Of Long Pyrene-Peg Chains On A Thin Carbon Nanotube, Peli̇n Deni̇z Akkuş, Ayşe Özge Kürkçüoğlu Levi̇tas
Molecular Dynamics Simulations Of Adsorption Of Long Pyrene-Peg Chains On A Thin Carbon Nanotube, Peli̇n Deni̇z Akkuş, Ayşe Özge Kürkçüoğlu Levi̇tas
Turkish Journal of Chemistry
Carbon nanotubes have emerged as highly promising theranostic agents due to their unique structural/physical features, high surface area, and high drug-loading capacity. The high cytotoxicity of carbon nanotubes can be eliminated by noncovalent coating using hydrophilic polymers. We investigated the adsorption of long pyrene functionalized polyethylene glycol (PEG) chains, PEG$_{2000}$ and PEG$_{5000}$, on a single-walled carbon nanotube (SWNT) from a crowded solution. Full-atom molecular dynamics simulations in explicit water were used to mimic the experimental conditions of noncovalent PEGylation with a stoichiometry of one SWNT to ten pyrene-PEG. Although the diffusional behavior of the pyrene molecules still attached to the …
On The Azo Dyes Derived From Benzoic And Cinnamic Acids Used As Photosensitizers In Dye-Sensitized Solar Cells, Luka Matovic, Nikola Tasic, Nemanja Trisovic, Jelena Ladarevic, Vesna Vitnik, Zeljko Vitnik, Branimir Grgur, Dusan Mijin
On The Azo Dyes Derived From Benzoic And Cinnamic Acids Used As Photosensitizers In Dye-Sensitized Solar Cells, Luka Matovic, Nikola Tasic, Nemanja Trisovic, Jelena Ladarevic, Vesna Vitnik, Zeljko Vitnik, Branimir Grgur, Dusan Mijin
Turkish Journal of Chemistry
In order to get a better insight into the relationship between molecular structure and photovoltaic performance, six monoazo dye molecules containing benzoic and cinnamic acid moieties were synthesized and their photovoltaic properties were studied. Three of them have not been previously used in solar cells. Spectroscopic measurements of the investigated compounds coupled with theoretical calculations were performed. Short-circuit current density, open-circuit voltage, and fill-factor were determined. It was found that a larger amount of short-circuit current density will be generated if the HOMO--LUMO energy gap is lower, determined by the stability of the molecule and the electronic effect of the …
Amino-Functionalized Mesostructured Cellular Foam Silica: A Highly Efficient And Recyclable Catalyst In The Knoevenagel Condensation Reaction, Dong Hao, Hongyuan Yang, Tengfei Zhang, Qing Liu
Amino-Functionalized Mesostructured Cellular Foam Silica: A Highly Efficient And Recyclable Catalyst In The Knoevenagel Condensation Reaction, Dong Hao, Hongyuan Yang, Tengfei Zhang, Qing Liu
Turkish Journal of Chemistry
Mesostructured cellular foam silica was functionalized by an amino group (MCF-NH$_{2})$ using the postsynthesis grafting method and utilized as a recyclable catalyst for the Knoevenagel reaction to afford $\alpha $, $\beta $-unsaturated compounds. The catalyst was systematically characterized by various analyses such as nitrogen adsorption, X-ray diffraction, Fourier transform infrared spectrophotometry, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and Hammett indicator method. The results showed that MCF-NH$_{2}$ catalyst was successfully prepared with a high surface area of 215 m$^{2}$ g$^{-1}$ and a large pore volume of 1.37 cm$^{3}$ g$^{-1}$. Compared with the nonfunctionalized MCF sample, the window and cell …
Magnetic Solid-Phase Extraction Based On Coriolus Versicolor-Immobilized $\Gamma $-Fe$_{2}$O$_{3}$ Nanoparticles For Preconcentration And Determination Of Al(Iii) In Water And Food Samples, Sadi̇n Özdemi̇r, Mustafa Serkan Yalçin, Ersi̇n Kilinç, Mustafa Soylak
Magnetic Solid-Phase Extraction Based On Coriolus Versicolor-Immobilized $\Gamma $-Fe$_{2}$O$_{3}$ Nanoparticles For Preconcentration And Determination Of Al(Iii) In Water And Food Samples, Sadi̇n Özdemi̇r, Mustafa Serkan Yalçin, Ersi̇n Kilinç, Mustafa Soylak
Turkish Journal of Chemistry
A method for preconcentration of Al(III) prior to its determination by inductively coupled plasma-optical emission spectrometry (ICP-OES) was developed because the sensitivity of ICP-OES is insufficient for trace-level measurement of Al(III). The method is based on the use of Coriolus versicolor}-immobilized $\gamma $-Fe$_{2}$O$_{3}$ magnetic nanoparticles as a solid phase sorbent. The best experimental conditions were found as pH 6.0, 2.0 mL/min flow rate, 100 mg amount of C. versicoloron 150 mg of $\gamma $-Fe$_{2}$O$_{3}$ nanoparticles, and 500 mL of sample volume. The Al(III) absorbed on biosorbent was eluted with 5.0 mL of 1.0 mol/L HCl. Limit of detection, limit of …
Reduced Graphene Oxide Supported Tin Oxide-Boron Oxide Flexible Paper Anodes For Li-Ion Batteries, Hi̇lal Köse, Şeyma Dombaycioğlu, Hatem Akbulut, Ali̇ Osman Aydin
Reduced Graphene Oxide Supported Tin Oxide-Boron Oxide Flexible Paper Anodes For Li-Ion Batteries, Hi̇lal Köse, Şeyma Dombaycioğlu, Hatem Akbulut, Ali̇ Osman Aydin
Turkish Journal of Chemistry
Freestanding tin oxide-boron oxide/reduced graphene oxide (SnO$_{2}$-B$_{2}$O$_{3}$/rGO) nanocomposite anode was produced for Li-ion cells. This binder-free flexible paper anode structure was fabricated by combining SnO$_{2}$-B$_{2}$O$_{3}$ composite and graphene oxide which were synthesized through the sol-gel method and Hummers' method, respectively. Field emission gun scanning electron microscopy, high-resolution transmission electron microscopy, energy dispersive X-ray spectrometer, Fourier transform infrared spectroscopy, Raman spectroscopy, and X-ray diffraction were utilized to characterize anode materials. The Williamson-Hall (W-H) analysis was applied using XRD data to determine crystal size and strain of the lattice. Electrochemical tests, cyclic voltammetry, and electrochemical impedance spectroscopy measurements were performed to determine …
Extraction Of High-Purity Silica From Rice Husk Via Hydrochloric Acid Leaching Treatment, Seitkhan Azat, Zhanar Sartova, Kalampyr Bekseitova, Kydyr Askaruly
Extraction Of High-Purity Silica From Rice Husk Via Hydrochloric Acid Leaching Treatment, Seitkhan Azat, Zhanar Sartova, Kalampyr Bekseitova, Kydyr Askaruly
Turkish Journal of Chemistry
The present paper aimed at the investigation of the effect of preliminary acid treatment on the structure and purity of extracted silica. In this study, the acid leaching of rice husk (RH) in 2 M hydrochloric acid solution before the calcination process at 600 $^{\circ}$C was proposed to achieve completely white silica with high specific surface area and low content of impurities. RH, selected from the Almaty Region, Kyzylorda Region, and Turkestan Region was used as the main silica source. The results confirmed that the highest purity (98.2%-99.7%) amorphous silica with a specific surface area between 120 and 980 m$^{2}$ …
Anticancer And Antiangiogenesis Activities Of Novel Synthesized 2-Substituted Benzimidazoles Molecules, Adem Güner, Eli̇fsu Polatli, Tamer Akkan, Hakan Bektaş, Canan Albay
Anticancer And Antiangiogenesis Activities Of Novel Synthesized 2-Substituted Benzimidazoles Molecules, Adem Güner, Eli̇fsu Polatli, Tamer Akkan, Hakan Bektaş, Canan Albay
Turkish Journal of Chemistry
In this study, novel 2-substituted benzimidazoles molecules having triazole, thiadiazole, and oxadiazole rings were synthesized and were evaluated by anticancer, antioxidant/oxidant status, genotoxicity, and antiangiogenesis assays. Anticancer activity of the compounds was determined by MTT (0.5, 5, and 50 $\mu $g/mL) and lactate dehydrogenase (LDH) release assays against human prostate and breast cancer cells. Oxidative status of cells was elicited by total oxidative stress and total antioxidant capacity methods. Chick chorioallantoic membrane assay was used to evaluate the antiangiogenic activity. Genotoxicity was evaluated by the sister chromatid exchange (SCE) and micronucleus (MN) tests in lymphocyte cultured human blood. Our results …
Design, Synthesis, Biological Evaluation And Molecular Docking Of Novel Molecules To Parp-1 Enzyme, Fati̇h Tok, Bedi̇a Kaymakçioğlu, Recep İlhan, Si̇nem Yilmaz, Petek Ballar Kirmizibayrak, Tuğba Taşkin Tok
Design, Synthesis, Biological Evaluation And Molecular Docking Of Novel Molecules To Parp-1 Enzyme, Fati̇h Tok, Bedi̇a Kaymakçioğlu, Recep İlhan, Si̇nem Yilmaz, Petek Ballar Kirmizibayrak, Tuğba Taşkin Tok
Turkish Journal of Chemistry
Poly (ADP-ribose) polymerase (PARP) enzyme catalyzes the transfer of ADP-ribose into target proteins. Therefore, PARP is responsible for DNA repair, cell proliferation, and cell death. In this study, potential PARP enzyme inhibitors were designed and synthesized. The synthesized compounds were elucidated by Fourier-transform infrared spectroscopy, $^{1}$H NMR, $^{13}$C NMR, heteronuclear single-quantum correlation, and mass spectrometry, and their purity was checked via thin-layer chromatography, high-performance liquid chromatography, and elemental analysis. A total of 63 newly synthesized compounds were screened in terms of PARP inhibition by cellular PARylation assay in the HeLa cell line. It was found that 19 compounds significantly inhibited …
Density Functional Theory-Supported Studies Of Structural And Electronic Properties Of Substituted-Phenol Derivatives Synthesized By Efficient O- Or C-Arylation Via Chan--Lam Or Suzuki Cross-Coupling Reactions, Hafiz Mansoor Ikram, Nasir Rasool, Muhammad Ali Hashmi, Muhammad Arfan Anjum, Kulsoom Ghulam Ali, Muhammad Zubair, Gulraiz Ahmad, Tariq Mahmood
Density Functional Theory-Supported Studies Of Structural And Electronic Properties Of Substituted-Phenol Derivatives Synthesized By Efficient O- Or C-Arylation Via Chan--Lam Or Suzuki Cross-Coupling Reactions, Hafiz Mansoor Ikram, Nasir Rasool, Muhammad Ali Hashmi, Muhammad Arfan Anjum, Kulsoom Ghulam Ali, Muhammad Zubair, Gulraiz Ahmad, Tariq Mahmood
Turkish Journal of Chemistry
The present study reports the efficient synthesis and computational studies of the structural and electronic properties of some interesting substituted phenol derivatives. Efficient and versatile procedures to synthesize a series of diaryl ether derivatives (2a-2c, 4a-4h) and bis-arylated products (5a-5c) are described. In this manuscript, using the commercially available starting material 1 and 3, a 1-step approach was developed by means of Cu(II)-mediated Chan-Lam and Pd-catalyzed Suzuki cross-coupling reactions to synthesize diaryl ether and bis-arylated products with moderate to good yields. The starting substrates, 2-bromo-4-methylphenol 1 or 2,4-dibromophenol 3, were both treated with several arylboronic acids, which led to the …
The Effect Of Starting Material Types On The Structure Of Graphene Oxide And Graphene, Fi̇li̇z Boran, Sevi̇l Çeti̇nkaya Gürer
The Effect Of Starting Material Types On The Structure Of Graphene Oxide And Graphene, Fi̇li̇z Boran, Sevi̇l Çeti̇nkaya Gürer
Turkish Journal of Chemistry
In this study, the effects of starting material types on graphene oxide (GO) are reported with the aim of developing graphene (GR) synthesis. The GOs were prepared from natural graphite (NG) powder and graphite nanoplate (GNp) based on the Hummers method. Two kinds of GR were successfully synthesized using GOs, which were prepared from NG and GNp in the presence of hydrazine and ammonia for 24 h at a 100 $^{\circ}$C reaction temperature. The synthesized GOs and GRs were characterized by X-ray diffraction (XRD) techniques, Fourier transform infrared, high-contrast transmission electron microscopy (HCTEM), dispersive Raman spectroscopic analyses, and elemental analyses. …
In Silico And In Vitro Evaluation Of The Biological Activity Of Some Organic Sulfur-Containing Compounds, Victoria Osipova, Maria Polovinkina, Anastasia Osipova, Yulia Gracheva, Andrey Okhlobystin
In Silico And In Vitro Evaluation Of The Biological Activity Of Some Organic Sulfur-Containing Compounds, Victoria Osipova, Maria Polovinkina, Anastasia Osipova, Yulia Gracheva, Andrey Okhlobystin
Turkish Journal of Chemistry
It was predicted, using the Prediction of Activity Spectra for Substances online software, that organic sulfur-containing compounds 2,6-di-tert-butyl-4-mercaptophenol (1), 2,6-di-tert-butyl-4-(3-mercaptopropyl)phenol (2), bis-3-[3,5-di-tert-butyl-4-hydroxyphenyl)propyl] sulfide (3), bis(3,5-di-tert- butyl-4-hydroxyphenyl) disulfide (4), diphenyl disulfide (5), dibenzyl disulfide (6), dibutyl disulfide (7), di-tert-butyl disulfide (8), diallyl disulfide (9), and methyl propyl trisulfide (10) could possess antioxidant activity and act as active scavengers of oxygen metabolites. The antiradical activity of these species was analyzed and it was shown that they were able to react with electrochemically generated the superoxide anion radical. The rate constants for reactions of 1-10 with the superoxide anion radical were calculated. The …
Natural Diterpenoid Alysine A Isolated From Teucrium Alyssifolium Exerts Antidiabetic Effect Via Enhanced Glucose Uptake And Suppressed Glucose Absorption, Alaatti̇n Şen, Buket Ayar, Anil Yilmaz, Özden Özgün Acar, Gurbet Çeli̇k Turgut, Gülaçti Topçu
Natural Diterpenoid Alysine A Isolated From Teucrium Alyssifolium Exerts Antidiabetic Effect Via Enhanced Glucose Uptake And Suppressed Glucose Absorption, Alaatti̇n Şen, Buket Ayar, Anil Yilmaz, Özden Özgün Acar, Gurbet Çeli̇k Turgut, Gülaçti Topçu
Turkish Journal of Chemistry
Teucrium species have been used in folk medicine as antidiabetic, antiinflammatory, antiulcer, and antibacterial agents. We have explored in vitro antidiabetic impacts of 2 natural diterpenoids, alysine A and alysine B, isolated from Teucrium alyssifolium. The lactate dehydrogenase (LDH) cytotoxicity assay, glucose uptake test, glucose utilization (glycogen content) test, glucose transport test, glucose absorption ($\alpha $-glucosidase activity) test, insulin secretion test, RNA isolation and cDNA synthesis assay, qPCR quantification assays, and statistical analyses were carried out in the present study. Alysine A exerted the following effects at non-cytotoxic doses: . Enhanced the glucose uptake, as much as the insulin in …
Electrochemical Responses Of Flexible Graphite In H$_2$So$_4$, Mehmet Suha Yazici
Electrochemical Responses Of Flexible Graphite In H$_2$So$_4$, Mehmet Suha Yazici
Turkish Journal of Chemistry
Asymmetric capacitors are gaining attention due to their hybrid nature with higher power and energy density compared to individual batteries or capacitors. Electrochemical and structural characteristics of flexible graphite in 40% H$_{2}$SO$_{4\, }$electrolyte are investigated using electrochemical and microscopy techniques. There is a correlation between intercalation of electrolyte and the enlargement of interlayer spacing and electrochemical response. Conditions favoring planar orientation are electrochemically less active and more stable in such corrosive electrolytes. There are response variations between plain and resin-impregnated flexible graphite samples. The reaction peak seems to be reversible for resin impregnated samples while plain samples show continuous intercalation. …
The Promoted Synthesis Of Minoxidil By Magnetic Nanoparticles Of Cobalt Ferrite (Cofe$_{2}$O$_4$) As A Heterogeneous Reusable Catalyst, Ronak Eisavi, Fateme Ahmadi, Behzad Zeynizadeh, Mehri Kouhkan
The Promoted Synthesis Of Minoxidil By Magnetic Nanoparticles Of Cobalt Ferrite (Cofe$_{2}$O$_4$) As A Heterogeneous Reusable Catalyst, Ronak Eisavi, Fateme Ahmadi, Behzad Zeynizadeh, Mehri Kouhkan
Turkish Journal of Chemistry
Minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide) was primarily recognized as a drug for reducing vascular resistance to blood flow. It was later introduced as a more important medicine for topical stimulation of hair growth and baldness reverting as well as treatment of androgenic alopecia through increasing prostaglandin endoperoxide synthesis. In this study, magnetic nanoparticles (MNPs) of spinel ferrites (MFe$_{2}$O$_{4}$, M = Co, Ni, Fe, Cu, and Zn) via solid-state grinding procedure were prepared and then characterized using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometer, and Fourier transform infrared techniques. The prepared nanoferrites were utilized as efficient and green heterogeneous …
Acetylene-Bridged Triazine Π-Conjugated Structures: Synthesis And Liquid Crystalline Properties, Ni̇hat Akkurt, Mohammed Hadi Ali Al-Jumaili, Belkiz Bi̇lgi̇n Eran, Hale Ocak, Lokman Torun
Acetylene-Bridged Triazine Π-Conjugated Structures: Synthesis And Liquid Crystalline Properties, Ni̇hat Akkurt, Mohammed Hadi Ali Al-Jumaili, Belkiz Bi̇lgi̇n Eran, Hale Ocak, Lokman Torun
Turkish Journal of Chemistry
We report the synthesis and liquid crystalline properties of a new type of tribranched compound built up from triazine as the central core and electron-rich triazine rings as peripheral groups. An equimolar mixture of the star-shaped compound based on the 1,3,5-triazine core with 4-dodecyloxybenzoic acid produced an organic salt exhibiting a columnar mesophase with a dendritic growing texture at low temperatures. The liquid crystalline properties of the triazine-based compound and organic salt were investigated by differential scanning calorimetry and polarizing optical microscopy.