Physical Sciences and Mathematics Commons^™

Copula Density Estimation By Total Variation Penalized Likelihood, Leming Qu, Yi Qian, Hui Xie

Leming Qu

Copulas are full measures of dependence among random variables. They are increasingly popular among academics and practitioners in financial econometrics for modeling comovements between markets, risk factors, and other relevant variables. A copula's hidden dependence structure that couples a joint distribution with its marginals makes a parametric copula non-trivial. An approach to bivariate copula density estimation is introduced that is based on a penalized likelihood with a total variation penalty term. Adaptive choice of the amount of regularization is based on approximate Bayesian Information Criterion (BIC) type scores. Performance are evaluated through the Monte Carlo simulation.

Problem #3468, Stan Wagon, Peter Saltzman, Joseph Devincentis

Stan Wagon, Retired

No abstract provided.

An Integrated Service Model Approach For Enabling Soa, Liang-Jie Zhang, Jia Zhang

Jia Zhang

No abstract provided.

Open & Mobile Equipment, Timothy J. Rowley

Timothy J Rowley

This was a "Lightning Presentation" about making cutting edge technology available to university students.

A Pair Of Operator Summation Formulas And Their Applications, Tian-Xiao He, Leetsch C. Hsu, Dongsheng Yin

Tian-Xiao He

Two types of symbolic summation formulas are reformulated using an extension of Mullin–Rota’s substitution rule in [R. Mullin, G.-C. Rota, On the foundations of combinatorial theory: III. Theory of binomial enumeration, in: B. Harris (Ed.), Graph Theory and its Applications, Academic Press, New York, London, 1970, pp. 167–213], and several applications involving various special formulas and identities are presented as illustrative examples.

Student Staff: A Village Philosophy, Lisa Caughron

Lisa Caughron

No abstract provided.

Composite Likelihood Em Algorithm With Applications To Multivariate Hidden Markov Model , Xin Gao, Peter Xuekun Song

COBRA Preprint Series

The method of composite likelihood is useful to deal with estimation and inference in parametric models with high-dimensional data, where the full likelihood approach renders to intractable computational complexity. We develop an extension of the EM algorithm in the framework of composite likelihood estimation in the presence of missing data or latent variables. We establish three key theoretical properties of the composite likelihood EM (CLEM) algorithm, including the ascent property, the algorithmic convergence and the convergence rate. The proposed method is applied to estimate the transition probabilities in multivariate hidden Markov model. Simulation studies are presented to demonstrate the empirical …

Limnological Assistance For The Lake Mead National Recreation Area In Meeting The Challenge Of The Water 2025 Initiative: Quarterly Report, Period Ending September 30, 2009, Margaret N. Rees

Limnological Studies

Project 1: Two advisory team meetings were attended this year; technical input was provided as appropriate; and summaries were prepared and delivered to Kent Turner. The SCOP Selenium Management Plan has been reviewed with two reports provided.

Project 2: Whitepapers on the carp die-off due to Koi Herpes Virus (KHV) and on lead-base paint use on launch ramps were finalized and delivered to Mr. Turner.

Project 3: The Interagency Monitoring Action Plan (I-MAP) for Quagga Mussels has been approved for implementation.

Project 5: Seven articles based on presentations at the Lake Mead Science Symposium have been approved by the technical …

Lake Mead National Recreation Area Monitoring And Evaluation Of Sensitive Wildlife: Quarterly Progress Report, Period Ending September 30, 2009, Margaret N. Rees

Wildlife Monitoring

Project 1. Relict Leopard Frog Monitoring, Management, and Research

• All milestones and deliverables associated with this MSHCP project are on schedule
• Mark-recapture surveys scheduled for fall have been initiated
• Two potential sites for translocations were visited to assess water availability
• Coordination continues on an upcoming translocation

Project 2. Bald Eagle Winter Monitoring and Evaluation

• All MSHCP milestones and deliverables are on schedule
• An annual project review presentation was given to Clark County

Project 3. Peregrine Falcon Monitoring and Evaluation

• This MSHCP project is on schedule for all milestones and deliverables
• Monitoring of Peregrine falcon 2009 breeding activities has been completed …

Nevada Interagency Volunteer Program: Helping Hands Across Public Lands – Phase Ii: Quarterly Progress Report, Period Covering July 1, 2009 To September 30, 2009, Margaret N. Rees

Get Outdoors Nevada

• The number of records in the volunteer database increased by 494, a 6% increase over last quarter. The database currently contains 6,720 records.
• Website activity increased, recording an average of 108,627 hits per month, an increase of 32% from last quarter, with an average of 12,415 pages viewed per month.
• Two corporations (Whole Foods and The Mirage) were contacted as part of the corporate mobile open house.
• National Public Lands Day was advertised through a daily memo to all 3000+ staff members of The Mirage.
• Preparations for the volunteer recognition banquet continued.

Front Matter

Journal of Digital Forensics, Security and Law

No abstract provided.

Masthead

Journal of Digital Forensics, Security and Law

No abstract provided.

Back Matter

Journal of Digital Forensics, Security and Law

No abstract provided.

The Multilevel Structures Of Nurbs And Nurblets On Intervals, Weiwei Zhu

Dissertations

This dissertation is concerned with the problem of constructing biorthogonal wavelets based on non-uniform rational cubic B-Splines on intervals. We call non-uniform rational B-Splines ``NURBs", and such biorthogonal wavelets ``NURBlets". Constructing NURBlets is useful in designing and representing an arbitrary shape of an object in the industry, especially when exactness of the shape is critical such as the shape of an aircraft. As we know presently most popular wavelet models in the industry are approximated at boundaries. In this dissertation a new model is presented that is well suited for generating arbitrary shapes in the industry with mathematical exactness throughout …

Indicadores Funcionales Y Estructurales Para Evaluar El Estado De Conservación De Humedales Costeros En El Sur De Tamaulipas, Alejandro Fierro-Cabo

School of Earth, Environmental, and Marine Sciences Faculty Publications and Presentations

El manejo adecuado de las zonas costeras requiere de herramientas que permitan detectar procesos degradantes en los ecosistemas estratégicos prestadores de servicios ambientales. Los indicadores ecológicos responden adecuadamente a esta necesidad en humedales costeros. Se estudiaron ocho humedales de origen y características distintas, con afectaciones contrastantes conocidas. Se seleccionaron los indicadores que mejor discriminaron los sitios y se utilizaron para evaluar la evolución del estado de conservación de los mismos. La correspondencia ecológica entre indicadores funcionales y estructurales no se confirmó en todos los casos, por lo que es necesario utilizar ambos tipos para obtener un mejor diagnóstico. En dicha …

Subcellular Min Oscillations As A Single-Cell Reporter Of The Action Of Polycations Protamine And Gentamicin On Escherichia Coli, Benjamin P.B. Downing, Andrew D. Rutenberg, Ahmed Touhami, Manfred Jericho

Physics and Astronomy Faculty Publications and Presentations

Background: In Escherichia coli, MinD-GFP fusion proteins show rapid pole to pole oscillations. The objective was to investigate the effects of extracellular cations on the subcellular oscillation of cytoplasmic MinD within Escherichia coli. Methodology/Principal Findings: We exposed bacteria to the extracellular cations Ca++, Mg++, the cationic antimicrobial peptide (CAP) protamine, and the cationic aminoglycoside gentamicin. We found rapid and substantial increases in the average MinD oscillation periods in the presence of any of these polyvalent cations. For Ca++ and Mg++ the increases in period were transient, even with a constant extracellular concentration, while increases in period for protamine or gentamicin …

Hierarchical Subject Inter-Relations In Physical Chemistry, Carl W. David

Chemistry Education Materials

Students mystified by the progression of topics in Physical Chemistry may gain insight into their path through the material if acquainted with the diagrams presented and discussed herein.

Confidence Intervals For Long Memory Regressions, Kyungduk Ko, Jaechoul Lee, Robert Lund

Kyungduk Ko

This paper proposes an accurate confidence interval for the trend parameter in a linear regression model with long memory errors. The interval is based upon an equivalent sum of squares method and is shown to perform comparably to a weighted least squares interval. The advantages of the proposed interval lies in its relative ease of computation and should be attractive to practitioners.

Bridging The Gap Between Systems Biology And Medicine, Gilles Clermont, Charles Auffray, Yves Moreau, David M. Rocke, Daniel Dalevi, Devdatt Dubhashi, Dana R. Marshall, Peter Raasch, Frank Dehne, Paolo Provero, Jesper Tegner, Bruce J. Aronow, Michael A. Langston, Mikael Benson

Faculty Publications and Other Works -- EECS

Abstract

Systems biology has matured considerably as a discipline over the last decade, yet some of the key challenges separating current research efforts in systems biology and clinically useful results are only now becoming apparent. As these gaps are better defined, the new discipline of systems medicine is emerging as a translational extension of systems biology. How is systems medicine defined? What are relevant ontologies for systems medicine? What are the key theoretic and methodologic challenges facing computational disease modeling? How are inaccurate and incomplete data, and uncertain biologic knowledge best synthesized in useful computational models? Does network analysis provide …

Readings In Targeted Maximum Likelihood Estimation, Mark J. Van Der Laan, Sherri Rose, Susan Gruber

U.C. Berkeley Division of Biostatistics Working Paper Series

This is a compilation of current and past work on targeted maximum likelihood estimation. It features the original targeted maximum likelihood learning paper as well as chapters on super (machine) learning using cross validation, randomized controlled trials, realistic individualized treatment rules in observational studies, biomarker discovery, case-control studies, and time-to-event outcomes with censored data, among others. We hope this collection is helpful to the interested reader and stimulates additional research in this important area.

Beam Spin Asymmetries In Deeply Virtual Compton Scattering (Dvcs) With Clas At 4.8 Gev, G. Gavalian, Gerard P. Gilfoyle, Et. Al.

Physics Faculty Publications

We report measurements of the beam spin asymmetry in deeply virtual Compton scattering (DVCS) at an electron beam energy of 4.8 GeV using the CLAS detector at the Thomas Jefferson National Accelerator Facility. The DVCS beam spin asymmetry has been measured in a wide range of kinematics, 1.0 < Q² < 2.8 (GeV/c)², 0.12 < x_B < 0.48, and 0.1 < −t < 0.8 (GeV/c)², using the reaction ep → e' p X. The number of H(e, e' γ p) and H(e, e'π⁰p) events are separated in each (Q², x_B, t …

Robustness Of Semiparametric Efficiency In Nearly-Correct Models For Two-Phase Samples, Thomas Lumley

UW Biostatistics Working Paper Series

Augmented inverse-probability weighted (AIPW) estimators for incomplete-data models typically do not have full semiparametric efficiency, but do have model-robustness properties not shared by the efficient estimator. We examine the performance of efficient and AIPW estimators when the complete-data model is nearly correctly specified, in the sense that the misspecification is not reliably detectable from the data by any possible diagnostic or test. Asymptotic results for these nearly true models are obtained by representing them as sequences of misspecified models that are mutually contiguous with a correctly specified model. For some least favorable direction of model misspecification the bias in the …

Competition Between Multiple Totally Asymmetric Simple Exclusion Processes For A Finite Pool Of Resources, L. Jonathan Cook, R. K. P. Zia, Beate Schmittmann

Beate Schmittmann

Using Monte Carlo simulations and a domain-wall theory, we discuss the effect of coupling several totally asymmetric simple exclusion processes (TASEPs) to a finite reservoir of particles. This simple model mimics directed biological transport processes in the presence of finite resources such as protein synthesis limited by a finite pool of ribosomes. If all TASEPs have equal length, we find behavior which is analogous to a single TASEP coupled to a finite pool. For the more generic case of chains with different lengths, several unanticipated regimes emerge. A generalized domain-wall theory captures our findings in good agreement with simulation results.

Synergistic Effects Of Mutations And Nanoparticle Templating In The Self-Assembly Of Cowpea Chlorotic Mottle Virus Capsids, Se Aniagyei, Cj Kennedy, B Stein, Da Willits, T Douglas, Mj Young, M De, Vm Rotello, D Srisathiyanarayanan, Cc Kao, B Dragnea

Vincent Rotello

A study of the in vitro nanoparticle-templated assembly of a mutant of cowpea chlorotic mottle virus lacking most of the N-terminal domain (residues 4-37), NDelta34, is presented. Mutant empty proteins assemble into empty capsids with a much broader distribution of sizes than the wild-type virus. This increased flexibility in the assembly outcomes is known to be detrimental for the assembly process in the presence of molecular polyanions. However, when rigid polyanionic cores are used, such as nanoparticles, the assembly process is restored and virus-like particles form. Moreover, the breadth of the nanoparticle-templated capsid size distribution becomes comparable with the wild-type …

Geometric Characterization Of Digital Objects: Algorithms And Applications To Image Analysis., Arindam Biswas Dr.

Doctoral Theses

Several problems of characterizing a digital object, and particularly, those related to boundary description, have been studied in this thesis. New algorithms and their applications to various aspects of image analysis and retrieval have been reported. A combinatorial technique for constructing the outer and inner isothetic covers of a digital object has been developed. The resolution of the background 2D grid can be changed by varying the grid spacing, and this procedure can be used to extract shape and topological information about the object. Next, an algorithm has been designed for constructing the orthogonal (convex) hull of a digital object …

Extracting Black Hole Physics From The Lattice, Simon Catterall, Toby Wiseman

Physics - All Scholarship

We perform lattice simulations of N D0-branes at finite temperature in the decoupling limit, namely 16 supercharge SU(N) Yang-Mills quantum mechanics in the 't Hooft limit. At low temperature this theory is conjectured to be dual to certain supergravity black holes. We emphasize that the existence of a non-compact moduli space renders the partition function of the quantum mechanics theory divergent, and we perform one loop calculations that demonstrate this explicitly. In consequence we use a scalar mass term to regulate this divergence and argue that the dual black hole thermodynamics may be recovered in the appropriate large N limit …

Super-Relaxed (Η)-Proximal Point Algorithms, Relaxed (Η)-Proximal Point Algorithms, Linear Convergence Analysis, And Nonlinear Variational Inclusions, Ram U. Verma, Ravi P. Agarwal

Mathematics and System Engineering Faculty Publications

We glance at recent advances to the general theory of maximal (set-valued) monotone mappings and their role demonstrated to examine the convex programming and closely related field of nonlinear variational inequalities. We focus mostly on applications of the super-relaxed (η)-proximal point algorithm to the context of solving a class of nonlinear variational inclusion problems, based on the notion of maximal (η)-monotonicity. Investigations highlighted in this communication are greatly influenced by the celebrated work of Rockafellar (1976), while others have played a significant part as well in generalizing the proximal point algorithm considered by Rockafellar (1976) to the case of the …

The Α,Α-Difluorinated Phosphonate L-Pser-Analogue: An Accessible Chemical Tool For Studying Kinase-Dependent Signal Transduction In Vitro, And In Living Cells, Kaushik Panigrahi, Marijean Eggen, Jun-Ho Maeng, Quanrong Shen, David B. Berkowitz

David Berkowitz Publications

This overview focuses on the (α,α-difluoromethylene)phosphonate mimic of phosphoserine (pCF₂Ser) and its application to the study of kinase-mediated signal transduction – pathways of great interest to drug development. The most versatile modes of access to these chemical biological tools are discussed, organized by method of PCF₂-C bond. The pCF₂-Ser mimic may be site-specifically incorporated into peptides (SPPS) and proteins (expressed protein ligation). This isopolar, dianionic pSer mimic results in a “constitutive phosphorylation” phenotype, and is seen to support native protein-protein interactions that depend upon serine phosphorylation. Signal transduction pathways studied with this chemical biological …

Causal Inference For Nested Case-Control Studies Using Targeted Maximum Likelihood Estimation, Sherri Rose, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

A nested case-control study is conducted within a well-defined cohort arising out of a population of interest. This design is often used in epidemiology to reduce the costs associated with collecting data on the full cohort; however, the case control sample within the cohort is a biased sample. Methods for analyzing case-control studies have largely focused on logistic regression models that provide conditional and not marginal causal estimates of the odds ratio. We previously developed a Case-Control Weighted Targeted Maximum Likelihood Estimation (TMLE) procedure for case-control study designs, which relies on the prevalence probability q0. We propose the use of …

Pore Size Characterization Of Monolithic Capillary Columns Using Capillary Flow Porometry, Yan Fang

Theses and Dissertations

A simple capillary flow porometer (CFP) was assembled for pore structure characterization of monolithic capillary liquid chromatography columns based on ASTM standard F316-86. Determination of differential pressures and flow rates through dry and wet samples provided the necessary information to determine the through-pore throat diameter, bubble point pore diameter, mean flow pore diameter, and pore distribution. Unlike measurements in bulk using traditional techniques to provide indirect information about the pore properties of monolithic columns, monoliths can be characterized in their original chromatographic forms with this system. The performance of the new CFP was first evaluated by characterizing the pore size …