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2009

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Articles 5701 - 5730 of 7616

Full-Text Articles in Physical Sciences and Mathematics

Iterative Methods For Computing Eigenvalues And Exponentials Of Large Matrices, Ping Zhang Jan 2009

Iterative Methods For Computing Eigenvalues And Exponentials Of Large Matrices, Ping Zhang

University of Kentucky Doctoral Dissertations

In this dissertation, we study iterative methods for computing eigenvalues and exponentials of large matrices. These types of computational problems arise in a large number of applications, including mathematical models in economics, physical and biological processes. Although numerical methods for computing eigenvalues and matrix exponentials have been well studied in the literature, there is a lack of analysis in inexact iterative methods for eigenvalue computation and certain variants of the Krylov subspace methods for approximating the matrix exponentials. In this work, we proposed an inexact inverse subspace iteration method that generalizes the inexact inverse iteration for computing multiple and clustered …


Direct Products And The Intersection Map Of Certain Classes Of Finite Groups, Julia Chifman Jan 2009

Direct Products And The Intersection Map Of Certain Classes Of Finite Groups, Julia Chifman

University of Kentucky Doctoral Dissertations

The main goal of this work is to examine classes of finite groups in which normality, permutability and Sylow-permutability are transitive relations. These classes of groups are called T , PT and PST , respectively. The main focus is on direct products of T , PT and PST groups and the behavior of a collection of cyclic normal, permutable and Sylow-permutable subgroups under the intersection map. In general, a direct product of finitely many groups from one of these classes does not belong to the same class, unless the orders of the direct factors are relatively prime. Examples suggest that …


From The Natural To The Supernatural, Rosalyn Lapier Jan 2009

From The Natural To The Supernatural, Rosalyn Lapier

Environmental Studies Faculty Publications

The Blackfeet understanding of the natural world is based on their religious belief system, world view and relationship with the supernatural world.


Characterisation Of Anthracyclines From A Cosmomycin D-Producing Species Of Streptomyces By Collisionally-Activated Dissociation And Ion Mobility Mass Spectrometry, Celine Kelso, Juan Diego Rojas, Renata L.A Furlan, Gabriel Padilla, Jennifer L. Beck Jan 2009

Characterisation Of Anthracyclines From A Cosmomycin D-Producing Species Of Streptomyces By Collisionally-Activated Dissociation And Ion Mobility Mass Spectrometry, Celine Kelso, Juan Diego Rojas, Renata L.A Furlan, Gabriel Padilla, Jennifer L. Beck

Faculty of Science - Papers (Archive)

Cultures of cosmomycin D-producing Streptomyces olindensis ICB20 that were propagated for many generations underwent mutations that resulted in production of a range of related anthracyclines by the bacteria. The anthracyclines that retained the two trisaccharide chains of the parent compound were separated by HPLC. Exact mass determination of these compounds revealed that they differed from cosmomycin D (CosD) in that they contained one to three fewer oxygen atoms (loss of hydroxyl groups). Some of the anthracyclines that were separated by HPLC had the same mass. The location from which the hydroxyl groups had been lost relative to CosD (on the …


Detrital Zircon Sedimentary Provenance Ages For The Eoarchaean Isua Supracrustal Belt Southern West Greenland: Juxtaposition Of An Imbricated Ca. 3700 Ma Juvenile Arc Against An Older Complex With 3920-3760 Ma Components, Allen P. Nutman, Clark R L Friend, Shane Paxton Jan 2009

Detrital Zircon Sedimentary Provenance Ages For The Eoarchaean Isua Supracrustal Belt Southern West Greenland: Juxtaposition Of An Imbricated Ca. 3700 Ma Juvenile Arc Against An Older Complex With 3920-3760 Ma Components, Allen P. Nutman, Clark R L Friend, Shane Paxton

Faculty of Science - Papers (Archive)

The amphibolite facies Eoarchaean Isua supracrustal belt (northern part of the Nuuk region, southern West Greenland) is dominated by strongly deformed metabasalts, with chert, banded iron formation, felsic volcanic and volcano-sedimentary rocks and minor gabbro and sedimentary carbonates. It comprises a suture zone between a northern terrane formed at ca. 3700 Ma and a southern one formed at ca. 3800 Ma. At the junction between these two terranes is a strongly tectonised, thin unit of metachert, BIF and carbonate-bearing rocks with minor detrital components, named the dividing sedimentary unit. Away from the belt, the northern terrane is dominated by ca. …


Eoarchaean Crustal Growth In West Greenland (Itsaq Gneiss Complex) And In Northeastern China (Anshan Area): Review And Synthesis, Allen P. Nutman, Vickie C. Bennett, Clark R L Friend, Frances Jenner, Yusheng Wan, Dunyi Liu Jan 2009

Eoarchaean Crustal Growth In West Greenland (Itsaq Gneiss Complex) And In Northeastern China (Anshan Area): Review And Synthesis, Allen P. Nutman, Vickie C. Bennett, Clark R L Friend, Frances Jenner, Yusheng Wan, Dunyi Liu

Faculty of Science - Papers (Archive)

Eoarchaean crust in West Greenland (the Itsaq Gneiss Complex, 3870-3600 Ma) is >80% by volume orthogneisses derived from plutonic tonalite-trondhjemite-granodiorite (TTG) suites,3850, c. 3810 and c. 3710 Mahave some compositional similarities to modern island arc basalts (IAB), suggesting their origin by hydrous fluxing of a suprasubduction-zone upper mantle wedge. Most of the Eoarchaean tonalites match in composition high-silica, low-magnesian adakites, whose petrogenesis is dominated by partial melting of garnetiferous mafic rocks at high pressure. However, associated with the tonalites are volumetrically minor more magnesian quartz diorites, whose genesis probably involved melting of depleted mantle to which some slab-derived component had …


Building On Our Strengths: A Framework To Reduce Racial Discrimination And Promote Diversity In Victoria, Y Paradies, L Chandrakumar, Natascha Klocker, M Frere, K Webster, G Berman, Peter Mclean Jan 2009

Building On Our Strengths: A Framework To Reduce Racial Discrimination And Promote Diversity In Victoria, Y Paradies, L Chandrakumar, Natascha Klocker, M Frere, K Webster, G Berman, Peter Mclean

Faculty of Science - Papers (Archive)

Building on our strengths: a framework to reduce race-based discrimination and support diversity in Victoria has been developed through a partnership between the Victorian Health Promotion Foundation (VicHealth), the Victorian Equal Opportunity and Human Rights Commission, the McCaughey Centre: VicHealth Centre for the Promotion of Mental Health and Community Wellbeing and the Onemda VicHealth Koori Health Unit. The McCaughey Centre and Onemda are both in the School of Population Health at the University of Melbourne.

Drawing on the best available evidence in Australia and internationally, this report outlines themes, strategies and priority settings for the development and implementation of activity …


Error Correlation Between Co2 And Co As Constraint For Co2 Flux Inversions Using Satellite Data, H Wang, D J. Jacob, M Kopacz, D B. A Jones, P Suntharalingam, J A. Fisher, R Nassar, S Pawson, J E. Nielsen Jan 2009

Error Correlation Between Co2 And Co As Constraint For Co2 Flux Inversions Using Satellite Data, H Wang, D J. Jacob, M Kopacz, D B. A Jones, P Suntharalingam, J A. Fisher, R Nassar, S Pawson, J E. Nielsen

Faculty of Science - Papers (Archive)

Inverse modeling of CO2 satellite observations to better quantify carbon surface fluxes requires a chemical transport model (CTM) to relate the fluxes to the observed column concentrations. CTM transport error is a major source of uncertainty. We show that its effect can be reduced by using CO satellite observations as additional constraint in a joint CO2-CO inversion. CO is measured from space with high precision, is strongly correlated with CO2, and is more sensitive than CO2 to CTM transport errors on synoptic and smaller scales. Exploiting this constraint requires statistics for the CTM transport error correlation between CO2 and CO, …


Late Llandovery (Early Silurian) Dendroid Graptolites From The Cotton Formation Near Forbes, New South Wales, R B. Rickards, Anthony J. Wright, G Thomas Jan 2009

Late Llandovery (Early Silurian) Dendroid Graptolites From The Cotton Formation Near Forbes, New South Wales, R B. Rickards, Anthony J. Wright, G Thomas

Faculty of Science - Papers (Archive)

A well-preserved dendroid graptolite fauna of Early Silurian (late Llandovery: probable turriculatus graptolite zone) age is described from the Cotton Formation near Forbes, New South Wales. A possible rhabdopleuran hemichordate is described from Australia for the fi rst time. The fauna consists of 13 taxa as follows: Dendrograptus sp. aff. D. avonleaensis, Dictyonema zalasiewiczi sp. nov., Dictyonema sp. aff. D. paululum australis, Dictyonema paululum australis, Dictyonema sp. aff. D. sp. cf. D. venustus of Bulman (?ssp. nov.), Dictyonema venustum, Dictyonema sp. cf. D. falciferum, Callograptus bridgecreekensis, Callograptus rigbyae, Callograptus sp. aff. C. ulahensis, Stelechocladia sp. cf. S. praeattenuata, Acanthograptus praedeckeri …


Development Of Non-Antibiotic-Resistant, Chromosomally Based, Constitutive And Inducible Expression Systems For Aroa-Attenuated Salmonella Enterica Serovar Typhimurium, Jake Matic, Tamsin D. Terry, David Van Bockel, Tracy A. Maddocks, David Tinworth, Michael Jennings, Steven P Djordjevic, Mark J. Walker Jan 2009

Development Of Non-Antibiotic-Resistant, Chromosomally Based, Constitutive And Inducible Expression Systems For Aroa-Attenuated Salmonella Enterica Serovar Typhimurium, Jake Matic, Tamsin D. Terry, David Van Bockel, Tracy A. Maddocks, David Tinworth, Michael Jennings, Steven P Djordjevic, Mark J. Walker

Faculty of Science - Papers (Archive)

Live-vaccine delivery systems expressing two model antigens from Mycoplasma hyopneumoniae, F2(P97) (Adh) and NrdF, were constructed using Salmonella enterica serovar Typhimurium aroA (STM-1), and immunogenicity in mice was evaluated. Recombinant plasmid-based expression (PBE) and chromosomally based expression (CBE) systems were constructed. The PBE system was formed by cloning both antigen genes into pJLA507 to create an operon downstream of temperature-inducible promoters. Constitutive CBE was achieved using a promoter-trapping technique whereby the promoterless operon was stably integrated into the chromosome of STM-1, and the expression of antigens was assessed. The chromosomal position of the operon was mapped in four clones. Inducible …


Absolute Calibration Of The Intramolecular Site Preference Of 15n Fractionation In Tropospheric N2o By Ft-Ir Spectroscopy, David W. T Griffith, Stephen D. Parkes, Vanessa Haverd, Clare Paton-Walsh, Stephen R. Wilson Jan 2009

Absolute Calibration Of The Intramolecular Site Preference Of 15n Fractionation In Tropospheric N2o By Ft-Ir Spectroscopy, David W. T Griffith, Stephen D. Parkes, Vanessa Haverd, Clare Paton-Walsh, Stephen R. Wilson

Faculty of Science - Papers (Archive)

Nitrous oxide (N2O) plays important roles in atmospheric chemistry both as a greenhouse gas and in stratospheric ozone depletion. Isotopic measurements of N2O have provided an invaluable insight into understanding its atmospheric sources and sinks. The preference for 15N fractionation between the central and terminal positions (the “site preference”) is particularly valuable because it depends principally on the processes involved in N2O production or consumption, rather than the 15N content of the substrate from which it is formed. Despite the value of measurements of the site preference, there is no internationally recognized standard reference material of accurately known and accepted …


The Cd-Loop Of Pai-2 (Serpinb2) Is Redundant In The Targeting, Inhibition And Clearance Of Cell Surface Upa Activity, Blake J. Cochran, Lakshitha P. Gunawardhana, Kara L. Perrow, Jodi A. Lee, Sergei A. Lobov, Marie Ranson Jan 2009

The Cd-Loop Of Pai-2 (Serpinb2) Is Redundant In The Targeting, Inhibition And Clearance Of Cell Surface Upa Activity, Blake J. Cochran, Lakshitha P. Gunawardhana, Kara L. Perrow, Jodi A. Lee, Sergei A. Lobov, Marie Ranson

Faculty of Science - Papers (Archive)

Background: Plasminogen activator inhibitor type-2 (PAI-2, SERPINB2) is an irreversible, specific inhibitor of the urokinase plasminogen activator (uPA). Since overexpression of uPA at the surface of cancer cells is linked to malignancy, targeting of uPA by exogenous recombinant PAI-2 has been proposed as the basis of potential cancer therapies. To this end, reproducible yields of high purity protein that maintains this targeting ability is required. Herein we validate the use in vitro of recombinant 6 × His-tagged-PAI-2 lacking the intrahelical loop between C and D alpha-helices (PAI- 2 ΔCD-loop) for these purposes.

Results: We show that PAI-2 ΔCD-loop …


Place And Music: Performing "The Region" On The New South Wales Far North Coast, Christopher R. Gibson Jan 2009

Place And Music: Performing "The Region" On The New South Wales Far North Coast, Christopher R. Gibson

Faculty of Science - Papers (Archive)

This paper draws on research conducted for over a decade on the musical cultures of the New South Wales Far North Coast, as a contribution to debates in geography and popular music studies on the links between music, place and articulations of cultural identities. Patterns of migration and economic restructuring over the last 20 years have transformed the Far North Coast region, with associated changes in the images conjured to describe the region – from those centred on dairying, fishing and sugar harvesting to those of a ‘lifestyle’ or ‘alternative’ region, with growth in employment in tourism, recreational services, ‘gourmet’ …


Darriwilian (Middle Ordovician) Conodonts From Thompson Creek, Nelson Province, New Zealand, Yong Yi Zhen, Ian G. Percival, Roger A. Cooper, John E. Simes, Anthony J. Wright Jan 2009

Darriwilian (Middle Ordovician) Conodonts From Thompson Creek, Nelson Province, New Zealand, Yong Yi Zhen, Ian G. Percival, Roger A. Cooper, John E. Simes, Anthony J. Wright

Faculty of Science - Papers (Archive)

A well preserved Middle Ordovician conodont fauna of 24 species has been recovered from seven samples of a small limestone lens exposed in Thompson Creek, northwest of Nelson, on the South Island of New Zealand. The presence of Histiodella holodentata, Baltoniodus? sp., Paroistodus originalis, P. horridus, Periodon macrodentatus, Protopanderodus sp. cf. P. varicostatus, Costiconus ethingtoni and Venoistodus balticus in the fauna indicates a Darriwilian (late Da2 to mid Da3) age. The occurrence of Ansella jemtlandica, Baltoniodus? sp., Periodon macrodentatus, Spinodus sp., Spinodus? sp. and Histiodella holodentata suggests a relatively deeper water (outer shelf to slope) setting, comparable with contemporaneous faunas, …


Late Neoproterozoic Passive Margin Of East Gondwana: Geochemical Constraints From The Anakie Inlier, Central Queensland, Australia, Christopher L. Fergusson, R Offler, T Green Jan 2009

Late Neoproterozoic Passive Margin Of East Gondwana: Geochemical Constraints From The Anakie Inlier, Central Queensland, Australia, Christopher L. Fergusson, R Offler, T Green

Faculty of Science - Papers (Archive)

Development of the East Gondwana passive margin and when it occurred are constrained by the composition of low grade mafic schists and U-Pb ages of detrital zircons in psammitic schists from the Bathampton Metamorphics in the Anakie Inlier of central Queensland. These rocks show considerable variation in light lithophile elements due to post-magmatic processes. They have flat heavy rare earth element patterns, low-TiO2 (<2 wt%) contents and their immobile element Ti, V, Y, La, Nb, Th and Zr values, indicate that they have an NMORB- like magmatic affinity. However, they differ from N-MORB in that they show light rare earth depleted patterns and lower incompatible trace element contents. Their relative low abundance and association with metasediments suggest they formed in a magma-poor rifted margin setting. They are associated with psammitic rocks with detrital zircon ages indicating probable deposition in the late Neoproterozoic at ca 600 Ma. A magma-poor rifted margin in northeastern Australia differs from the volcanic passive setting that occurred in southeastern Australia at this time. These findings support development of the East Gondwana margin at 600 Ma that may have been related to rifting of a microcontinent off East Gondwana well after the breakup of Rodinia at ca 750 Ma.


Middle Ordovician (Darriwilian) Brachiopods And Trilobites From Thompson Creek, Northwest Nelson, New Zealand, Ian G. Percival, Anthony J. Wright, Roger A. Cooper, John E. Simes, Yong Yi Zhen Jan 2009

Middle Ordovician (Darriwilian) Brachiopods And Trilobites From Thompson Creek, Northwest Nelson, New Zealand, Ian G. Percival, Anthony J. Wright, Roger A. Cooper, John E. Simes, Yong Yi Zhen

Faculty of Science - Papers (Archive)

A well preserved Middle Ordovician shelly fauna, represented by twelve species of lingulate brachiopods and one trilobite genus, was recovered from an allochthonous limestone lens exposed in Thompson Creek, northwest of Nelson, on the South Island of New Zealand. The stratigraphic setting is unclear as the limestone is situated in the Takaka Terrane adjacent to the Anatoki Fault, separating this terrane from the Buller Terrane. The original depositional environment of the limestone is interpreted as relatively deep water (outer shelf to upper slope). Lingulate brachiopods described include the new species Hyperobolus? thompsonensis sp. nov., Cyrtonotreta robusta sp. nov., Scaphelasma paturauensis …


Molecular And Morphological Description Of A Hepatozoon Species In Reptiles And Their Ticks In The Northern Territory, Australia, Inger-Marie E. Vilcins, Beata Ujvari, Julie M. Old, Elizabeth Deane Jan 2009

Molecular And Morphological Description Of A Hepatozoon Species In Reptiles And Their Ticks In The Northern Territory, Australia, Inger-Marie E. Vilcins, Beata Ujvari, Julie M. Old, Elizabeth Deane

Faculty of Science - Papers (Archive)

Ticks, representing 3 species of Amblyomma, were collected from the water python (Liasis fuscus) and 3 additional reptile species in the Northern Territory, Australia, and tested for the presence of Hepatozoon sp., the most common blood parasites of snakes. In addition, blood smears were collected from 5 reptiles, including the water python, and examined for the presence of the parasite. Hepatozoon sp. DNA was detected in all tick and reptile species, with 57.7% of tick samples (n = 187) and 35.6% of blood smears (n = 35) showing evidence of infection. Phylogenetic analysis of the 18S rRNA gene demonstrated that …


Climate Change At The Landscape Scale: Predicting Fine-Grained Spatial Heterogeneity In Warming And Potential Refugia For Vegetation, Michael B. Ashcroft, Laurie Chisholm, Kris French Jan 2009

Climate Change At The Landscape Scale: Predicting Fine-Grained Spatial Heterogeneity In Warming And Potential Refugia For Vegetation, Michael B. Ashcroft, Laurie Chisholm, Kris French

Faculty of Science - Papers (Archive)

Current predictions of how species will respond to climate change are based on coarse-grained climate surfaces or idealized scenarios of uniform warming. These predictions may erroneously estimate the risk of extinction because they neglect to consider spatially heterogenous warming at the landscape scale or identify refugia where species can persist despite unfavourable regional climate. To address this issue, we investigated the heterogeneity in warming that has occurred in a 10 km × 10 km area from 1972 to 2007. We developed estimates by combining long-term daily observations from a limited number of weather stations with a more spatially comprehensive dataset …


Gremo: A Gis-Based Generic Model For Estimating Relative Wave Exposure, Austen Pepper, Marjetta L. Puotinen Jan 2009

Gremo: A Gis-Based Generic Model For Estimating Relative Wave Exposure, Austen Pepper, Marjetta L. Puotinen

Faculty of Science - Papers (Archive)

Wave exposure plays a major role in shaping the ecological structure of nearshore communities, with different community types able to survive and/or thrive when typically exposed to different levels of wave energy. This can be quantified by taking direct field measurements with wave buoys over time and then manipulating the data to derive typical conditions. However, taking these measurements is only feasible for very limited areas due to logistical constraints, and generating them with numerical wave models can also be expensive to run and may require data inputs that are either lacking or are highly uncertain. Instead, the relative differences …


Crystallin Proteins And Amyloid Fibrils, Heath Ecroyd, John A. Carver Jan 2009

Crystallin Proteins And Amyloid Fibrils, Heath Ecroyd, John A. Carver

Faculty of Science - Papers (Archive)

Improper protein folding (misfolding) can lead to the formation of disordered (amorphous) or ordered (amyloid fibril) aggregates. The major lens protein, alpha-crystallin, is a member of the small heat-shock protein (sHsp) family of intracellular molecular chaperone proteins that prevent protein aggregation. Whilst the chaperone activity of sHsps against amorphously aggregating proteins has been well studied, its action against fibril-forming proteins has received less attention despite the presence of sHsps in deposits found in fibril-associated diseases (e.g. Alzheimer's and Parkinson's). In this review, the literature on the interaction of alpha B-crystallin and other sHsps with fibril-forming proteins is summarized. In particular, …


(-)-Epigallocatechin-3-Gallate (Egcg) Maintains K-Casein In Its Pre-Fibrillar State Without Redirecting Its Aggregation Pathway, Sean A. Hudson, Heath Ecroyd, Francis C. Dehle, Ian F. Musgrave, John Carver Jan 2009

(-)-Epigallocatechin-3-Gallate (Egcg) Maintains K-Casein In Its Pre-Fibrillar State Without Redirecting Its Aggregation Pathway, Sean A. Hudson, Heath Ecroyd, Francis C. Dehle, Ian F. Musgrave, John Carver

Faculty of Science - Papers (Archive)

The polyphenol (-)-epigallocatechin-3-gallate (EGCG) has recently attracted much research interest in the field of protein-misfolding diseases because of its potent anti-amyloid activity against amyloid-beta, alpha-synuclein and huntingtin, the amyloid-fibril-forming proteins involved in Alzheimer's, Parkinson's and Huntington's diseases, respectively. EGCG redirects the aggregation of these polypeptides to a disordered off-folding pathway that results in the formation of non-toxic amorphous aggregates. whether this anti-fibril activity is specific to these disease-related target proteins or ismore generic remains to be established. In addition, the mechanism by which EGCG exerts its effects, as with all anti-amyloidogenic polyphenols, remains unclear. To address these aspects, we have …


New Proteins Identified In Epididymal Fluid From The Platypus (Ornithorhynchus Anatinus), Jean-Louis Dacheux, Francoise Dacheux, Valerie Labas, Heath Ecroyd, Brett Nixon, Russell C. Jones Jan 2009

New Proteins Identified In Epididymal Fluid From The Platypus (Ornithorhynchus Anatinus), Jean-Louis Dacheux, Francoise Dacheux, Valerie Labas, Heath Ecroyd, Brett Nixon, Russell C. Jones

Faculty of Science - Papers (Archive)

The platypus epididymal proteome is being studied because epididymal proteins are essential for male fertility in mammals and it is considered that knowledge of the epididymal proteome in an early mammal would be informative in assessing the convergence and divergence of proteins that are important in the function of the mammalian epididymis. Few of the epididymal proteins that have been identified in eutherian mammals were found in platypus caudal epididymal fluid, and the major epididymal proteins in the platypus (PXN-FBPL, SPARC and E-OR20) have never been identified in the epididymis of any other mammal.


Macroglobulin And Haptoglobin Suppress Amyloid Formation By Interacting With Prefibrillar Protein Species, Justin J. Yerbury, Janet R. Kumita, Sarah Meehan, Christopher M. Dobson, Mark R. Wilson Jan 2009

Macroglobulin And Haptoglobin Suppress Amyloid Formation By Interacting With Prefibrillar Protein Species, Justin J. Yerbury, Janet R. Kumita, Sarah Meehan, Christopher M. Dobson, Mark R. Wilson

Faculty of Science - Papers (Archive)

α2-Macroglobulin (α2M) and haptoglobin (Hp) are both abundant secreted glycoproteins that are best known for their protease trapping and hemoglobin binding activities, respectively. Like the small heat shock proteins, both these glycoproteins have in common the ability to protect a range of proteins from stress-induced amorphous aggregation and have been described as extracellular chaperones. Using an array of biophysical techniques, this study establishes that in vitro at substoichiometric levels and under physiological conditions α2M and Hp both inhibit the formation of amyloid fibrils from a range of proteins. We also provide evidence that both …


Structural Characterization Of Clusterin-Chaperone Client Protein Complexes, Amy R. Wyatt, Justin J. Yerbury, Mark R. Wilson Jan 2009

Structural Characterization Of Clusterin-Chaperone Client Protein Complexes, Amy R. Wyatt, Justin J. Yerbury, Mark R. Wilson

Faculty of Science - Papers (Archive)

Clusterin (CLU) is a potent extracellular chaperone that inhibits protein aggregation and precipitation otherwise caused by physical or chemical stresses (e.g. heat, reduction). This action involves CLU forming soluble high molecular weight (HMW) complexes with the client protein. Other than their unquantified large size, the physical characteristics of these complexes were previously unknown. In this study, HMW CLU-citrate synthase (CS), HMW CLU-fibrinogen (FGN), and HMW CLU-glutathione S-transferase (GST) complexes were generated in vitro, and their structures studied using size exclusion chromatography (SEC), ELISA, SDS-PAGE, dynamic light scattering (DLS), bisANS fluorescence, and circular dichroism spectrophotometry (CD). Densitometry of …


Therapeutic Targets In Extracellular Protein Deposition Diseases, Amy R. Wyatt, Justin J. Yerbury, Stephen Poon, Mark R. Wilson Jan 2009

Therapeutic Targets In Extracellular Protein Deposition Diseases, Amy R. Wyatt, Justin J. Yerbury, Stephen Poon, Mark R. Wilson

Faculty of Science - Papers (Archive)

Many litres of fluids are found outside cells in the human body. These fluids are rich in dissolved proteins that each have a characteristic three dimensional shape, necessary for normal function, which has been attained by the correct folding of their polypeptide chain(s). The structure of these extracellular proteins can be damaged by a variety of environmental stresses (e. g. heat and oxidation) leading to their partial unfolding and aggregation. This in turn can produce toxic soluble aggregates and/or large insoluble protein deposits, either of which can disrupt normal body function (e. g. in Alzheimer's disease and the systemic amyloidoses). …


Tectonic Evolution Of The Ordovician Macquarie Arc, Central New South Wales: Arguments For Subduction Polarity And Anticlockwise Rotation, Christopher L. Fergusson Jan 2009

Tectonic Evolution Of The Ordovician Macquarie Arc, Central New South Wales: Arguments For Subduction Polarity And Anticlockwise Rotation, Christopher L. Fergusson

Faculty of Science - Papers (Archive)

The Ordovician Macquarie Arc is most widely exposed in the Lachlan Fold Belt of central New South Wales. Complex relationships between the arc and the Ordovician turbidite mega-fan are partly explained by anticlockwise rotation of the arc during the Ordovician. Thus, initially two lobes of the mega-fan formed to the north and south of the east-west trending arc, using present-day coordinates. The arc consists of the western Goonumbla-Trangie Volcanic Belt, replacing the inappropriate term Junee-Narromine Volcanic Belt, and an eastern composite of the Molong, Rockley-Gulgong and Kiandra Volcanic Belts. These two major segments of the arc are separated by Ordovician …


U-Pb Zircon Geochronology And Nd Isotopic Signatures Of The Pre-Mesozoic Metamorphic Basement Of The Eastern Peruvian Andes: Growth And Provenance Of A Late Neoproterozoic To Carboniferous Accretionary Orogen On The Northwest Margin Of Gondwana, A Cardona, U G. Cordani, J Ruiz, V A. Valencia, R Armstrong, D Chew, A Nutman, A W. Sanchez Jan 2009

U-Pb Zircon Geochronology And Nd Isotopic Signatures Of The Pre-Mesozoic Metamorphic Basement Of The Eastern Peruvian Andes: Growth And Provenance Of A Late Neoproterozoic To Carboniferous Accretionary Orogen On The Northwest Margin Of Gondwana, A Cardona, U G. Cordani, J Ruiz, V A. Valencia, R Armstrong, D Chew, A Nutman, A W. Sanchez

Faculty of Science - Papers (Archive)

This study integrates U-Pb zircon geochronology (from LAM-ICP-MS, SHRIMP, and TIMS) with Nd isotopic data from orthogneisses and metasedimentary rocks of the pre-Mesozoic basement of the eastern Peruvian Andes to provide new information on the tectonic evolution and Neoproterozoic-Paleozoic paleogeography of this segment of the proto-Andean margin. A high-grade orthogneiss unit yields U-Pb zircon protolith crystallization ages of ~613 Ma. It was metamorphosed and intruded by an Early Ordovician granitoid. Subsequently, two different volcano-sedimentary sequences were laid down and metamorphosed, probably as a consequence of terrane accretion. The older sequence was deposited and metamorphosed between 450 and 420 Ma, and …


In Situ U-Pb, O And Hf Isotopic Compositions Of Zircon And Olivine From Eoarchaean Rocks, West Greenland: New Insights To Making Old Crust, Joe Hiess, Vickie C. Bennett, Allen P. Nutman, Ian S. Williams Jan 2009

In Situ U-Pb, O And Hf Isotopic Compositions Of Zircon And Olivine From Eoarchaean Rocks, West Greenland: New Insights To Making Old Crust, Joe Hiess, Vickie C. Bennett, Allen P. Nutman, Ian S. Williams

Faculty of Science - Papers (Archive)

The sources and petrogenetic processes that generated some of the Earth's oldest continental crust have been more tightly constrained via an integrated, in situ (U-Pb, O and Hf) isotopic approach. The minerals analysed were representative zircon from four Eoarchaean TTG tonalites and two felsic volcanic rocks, and olivine from one harzburgite/dunite of the Itsaq Gneiss Complex (IGC), southern West Greenland. The samples were carefully chosen from localities with least migmatisation, metasomatism and strain. Zircon was thoroughly characterized prior to analysis using cathodoluminescence, scanning electron, reflected and transmitted light imaging. The zircon from all but one sample showed only minor post-magmatic …


Validation Of Version-4.61 Methane And Nitrous Oxide Observed By Mipas, S Payan, C Camy-Peyret, H Oelhaf, G Wetzel, G Maucher, C Keim, M Pirre, N Huret, A Engel, M C. Volk, H Kuellmann, J Kuttippurath, U Cortesi, G Bianchini, F Mencaraglia, P Raspollini, G Redaelli, C Vigouroux, M De Maziere, S Mikuteit, T Blumenstock, Voltaire A. Velazco, J Notholt, E Mahieu, P Duchatelet, D Smale, S Wood, N Jones, C Piccolo, V Payne, A Bracher, N Glatthor, G P. Stiller, K Grunow, P Jeseck, Y Te, A Butz Jan 2009

Validation Of Version-4.61 Methane And Nitrous Oxide Observed By Mipas, S Payan, C Camy-Peyret, H Oelhaf, G Wetzel, G Maucher, C Keim, M Pirre, N Huret, A Engel, M C. Volk, H Kuellmann, J Kuttippurath, U Cortesi, G Bianchini, F Mencaraglia, P Raspollini, G Redaelli, C Vigouroux, M De Maziere, S Mikuteit, T Blumenstock, Voltaire A. Velazco, J Notholt, E Mahieu, P Duchatelet, D Smale, S Wood, N Jones, C Piccolo, V Payne, A Bracher, N Glatthor, G P. Stiller, K Grunow, P Jeseck, Y Te, A Butz

Faculty of Science - Papers (Archive)

The ENVISAT validation programme for the atmospheric instruments MIPAS, SCIAMACHY and GOMOS is based on a number of balloon-borne, aircraft, satellite and ground-based correlative measurements. In particular the activities of validation scientists were coordinated by ESA within the ENVISAT Stratospheric Aircraft and Balloon Campaign or ESABC.


Climate Change In The Dead Heart Of Australia, Joshua Larsen, Gerald C. Nanson, Timothy J. Cohen, Brian G. Jones, John D. Jansen, Jan-Hendrik May Jan 2009

Climate Change In The Dead Heart Of Australia, Joshua Larsen, Gerald C. Nanson, Timothy J. Cohen, Brian G. Jones, John D. Jansen, Jan-Hendrik May

Faculty of Science - Papers (Archive)

Despite the absence of large-scale glaciation, the Australian continent has experienced substantial environmental change throughout the Quaternary period. This is especially pronounced in central Australia, where one seventh of the continent is drained internally to the depocentre, and lowest point in Australia, Lake Eyre (Figure 1). Research has shown that at one time, large sandy braided and meandering rivers carried water through dunefields to a large freshwater lake system. Today, the rivers are hostage to the dunefield, and floodwaters might only reach Lake Eyre once every ten years or so. In order to understand the development of this arid desert …