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Articles 3811 - 3840 of 8620
Full-Text Articles in Physical Sciences and Mathematics
Default Rate On Auto Loans, Jessica Jones
Default Rate On Auto Loans, Jessica Jones
Undergraduate Research Conference
In completing this model, we want to view a portfolio of loans at a bank and be able to predict the default rate on an auto loan. We also want to be able to look at an individual loan and predict the default probability taking into consideration interest rate, term, number of days late, times late, original loan amount, collateral value, LTV and credit score. The data will assist in forecasting default rates in future years and in projecting income and loss for a bank. We predict at the end of the model, credit score will be the main indicator …
War By Government: Which Systems Are Most Likely To Engage In Conflict?, Courtney Lemon
War By Government: Which Systems Are Most Likely To Engage In Conflict?, Courtney Lemon
Undergraduate Research Conference
No abstract provided.
Multiple Regression Analysis: Sfa Professors' Salaries, Latonya Edmeade
Multiple Regression Analysis: Sfa Professors' Salaries, Latonya Edmeade
Undergraduate Research Conference
There is always a certain curiosity and controversy surrounding professor’s salaries and whether they are overpaid or not paid enough. We have decided to try and untangle this wonder by creating a regression model in which the average person could easily understand while solving this lingering question. It is the average student’s opinion that professors make way too much compared to their daily tasks.
On the other hand, many professors are always complaining that they are not paid enough with their advanced degree and work load, not to mention the option always hovers over their head of pursuing a different …
Analysis Of D+ → K-Π+ E+ Νe And D+ → K- Π+ Μ+ Νμ Semileptonic Decays, Raymond Mountain, Marina Artuso, S. Blusk, Sadia Khalil
Analysis Of D+ → K-Π+ E+ Νe And D+ → K- Π+ Μ+ Νμ Semileptonic Decays, Raymond Mountain, Marina Artuso, S. Blusk, Sadia Khalil
Physics - All Scholarship
Using a large sample (~11800 events) of D^+ into K^- pi^+ e^+ nu_e and D^+ into K^- pi^+ mu^+ nu_mu decays collected by the CLEO-c detector running at the psi(3770), we measure the helicity basis form factors free from the assumptions of spectroscopic pole dominance and provide new, accurate measurements of the absolute branching fractions for D^+ into K^- pi^+ e^+ nu_e and D^+ into K^- pi^+ mu^+ nu_mu decays. We find branching fractions which are consistent with previous world averages. Our measured helicity basis form factors are consistent with the spectroscopic pole dominance predictions for the three main helicity …
Analysis Of D+ To K- Pi+ E+ Nu_E And D+ To K- Pi+ Mu+ Nu_Mu Semileptonic Decays, Raymond Mountain, Marina Artuso, S. Blusk, Sadia Khalil
Analysis Of D+ To K- Pi+ E+ Nu_E And D+ To K- Pi+ Mu+ Nu_Mu Semileptonic Decays, Raymond Mountain, Marina Artuso, S. Blusk, Sadia Khalil
Physics - All Scholarship
Using a large sample (~11800 events) of D^+ into K^- pi^+ e^+ nu_e and D^+ into K^- pi^+ mu^+ nu_mu decays collected by the CLEO-c detector running at the psi(3770), we measure the helicity basis form factors free from the assumptions of spectroscopic pole dominance and provide new, accurate measurements of the absolute branching fractions for D^+ into K^- pi^+ e^+ nu_e and D^+ into K^- pi^+ mu^+ nu_mu decays. We find branching fractions which are consistent with previous world averages. Our measured helicity basis form factors are consistent with the spectroscopic pole dominance predictions for the three main helicity …
Measuring The Effective Wavelength Of Chara Classic, Emily Collins Bowsher
Measuring The Effective Wavelength Of Chara Classic, Emily Collins Bowsher
Physics and Astronomy Theses
This thesis presents an engineering project measuring the effective wavelength of the CHARA Classic beam combiner on the CHARA Array. Knowing the actual effective wavelength of light observed is very important because that value is necessary for determining astrophysical parameters of stars. Currently, the value used for CHARA Classic data comes from a model of the system and is based on numbers published by the manufacturer of the filter; it is not derived from measurements done on the system directly. We use two data collection methods to observe standard stars of different spectral types and calculate the wavelength of light …
The Inner Power Of A Graph, Neal Livesay
The Inner Power Of A Graph, Neal Livesay
Theses and Dissertations
We define a new graph operation called the inner power of a graph. The construction is similar to the direct power of graphs, except that factors are intertwined in such a way that certain structural properties of graphs are more clearly reflected in their inner powers. We investigate various properties of inner powers, such as connectivity, bipartiteness, and their interaction with the direct product. We explore possible connections between inner powers and the problem of cancellation over the direct product of graphs.
Ontology And Knowledge Base Of Brittle Deformation Microstructures For The San Andreas Fault Observatory At Depth (Safod) Core Samples, Cynthia Marie Broda
Ontology And Knowledge Base Of Brittle Deformation Microstructures For The San Andreas Fault Observatory At Depth (Safod) Core Samples, Cynthia Marie Broda
Geosciences Theses
The quest to answer fundamental questions and solve complex problems is a principal tenet of Earth science. The pursuit of scientific knowledge has generated profuse research, resulting in a plethora of information-rich resources. This phenomenon offers great potential for scientific discovery. However, a deficiency in information connectivity and processing standards has become evident. This deficiency has resulted in a demand for tools to facilitate and process this upsurge in information. This ontology project is an answer to the demand for information processing tools. The primary purpose of this domain-specific ontology and knowledge base is to organize, connect, and correlate research …
Testing And Maintenance In The Video Game Industry Today, Anthony A. Jarman
Testing And Maintenance In The Video Game Industry Today, Anthony A. Jarman
Senior Honors Theses
Testing and maintenance are important when designing any type of software, especially video games. Since the gaming industry began, testing and maintenance techniques have evolved and changed. In order to understand how testing and maintenance techniques are practiced in the gaming industry, several key elements must be examined. First, specific testing and maintenance techniques that are most useful for video games must be analyzed to understand their effectiveness. Second, the processes used for testing and maintaining video games at the beginning of the industry must be reviewed in order to see how far testing and maintenance techniques have progressed. Third, …
Nonparametric Regression With Missing Outcomes Using Weighted Kernel Estimating Equations, Lu Wang, Andrea Rotnitzky, Xihong Lin
Nonparametric Regression With Missing Outcomes Using Weighted Kernel Estimating Equations, Lu Wang, Andrea Rotnitzky, Xihong Lin
Harvard University Biostatistics Working Paper Series
No abstract provided.
Nonparametric And Semiparametric Analysis Of Current Status Data Subject To Outcome Misclassification, Victor G. Sal Y Rosas, James P. Hughes
Nonparametric And Semiparametric Analysis Of Current Status Data Subject To Outcome Misclassification, Victor G. Sal Y Rosas, James P. Hughes
UW Biostatistics Working Paper Series
In this article, we present nonparametric and semiparametric methods to analyze current status data subject to outcome misclassification. Our methods use nonparametric maximum likelihood estimation (NPMLE) to estimate the distribution function of the failure time when sensitivity and specificity may vary among subgroups. A nonparametric test is proposed for the two sample hypothesis testing. In regression analysis, we apply the Cox proportional hazard model and likelihood ratio based confidence intervals for the regression coefficients are proposed. Our methods are motivated and demonstrated by data collected from an infectious disease study in Seattle, WA.
Weak Primary Decomposition Of Modules Over A Commutative Ring, Harrison Stalvey
Weak Primary Decomposition Of Modules Over A Commutative Ring, Harrison Stalvey
Mathematics Theses
This paper presents the theory of weak primary decomposition of modules over a commutative ring. A generalization of the classic well-known theory of primary decomposition, weak primary decomposition is a consequence of the notions of weakly associated prime ideals and nearly nilpotent elements, which were introduced by N. Bourbaki. We begin by discussing basic facts about classic primary decomposition. Then we prove the results on weak primary decomposition, which are parallel to the classic case. Lastly, we define and generalize the Compatibility property of primary decomposition.
On Minimal Surfaces And Their Representations, Brian Fitzpatrick
On Minimal Surfaces And Their Representations, Brian Fitzpatrick
Math Honors Theses
We consider the problem of representation of minimal surfaces in the euclidean space and provide a proof of Bernstein’s theorem. This pa- per serves as a concise and self-contained reference to the theory of minimal surfaces.
On The State Hierarchy Of Exploding Automata, Matthew Maly
On The State Hierarchy Of Exploding Automata, Matthew Maly
Computer Science Honors Theses
A recently revisited question in finite automata theory considers the possible numbers n and d for which there exists an n-state minimal NFA with a minimal equivalent DFA of d states. We present a new class of finite automata, the NFA En of n states, which in a sense contains half of the state hierarchy [n, 2n]; that is, by making small modifications to En, we can create a minimal equivalent DFA of d states for any d ∈ (2n−1, 2n]. Although this is not stronger than the most recent of work that has been done on the problem, the …
Surface Plasmon Enhancement Of Organic Photovoltaic Devices, Megan Holtz
Surface Plasmon Enhancement Of Organic Photovoltaic Devices, Megan Holtz
Physics & Astronomy Honors Theses
Organic photovoltaic (OPV) cells have recently attracted attention due to their low cost and easy fabrication. However, their efficiency remains low compared to silicon-based photovoltaics. OPV cells generate power through the creation of an exciton by light. The diffusion length for the electron-hole pair in most organic photovoltaic material is on the order of 100 nm, which limits the overall thickness of the device. The maximum 100 nm thickness of the cell reduces the absorption of the device, which ultimately lowers its efficiency. The absorption may be boosted at certain wavelengths by the excitation of surface plasmons. Surface plasmons are …
Spitzer Mid-Infrared Spectroscopy Of Compact Symmetric Objects: What Powers Radio-Loud Active Galactic Nuclei?, Kyle W. Willett, John T. Stocke, Jeremy K. Darling, Eric S. Perlman
Spitzer Mid-Infrared Spectroscopy Of Compact Symmetric Objects: What Powers Radio-Loud Active Galactic Nuclei?, Kyle W. Willett, John T. Stocke, Jeremy K. Darling, Eric S. Perlman
Aerospace, Physics, and Space Science Faculty Publications
We present low- and high-resolution mid-infrared (mid-IR) spectra and photometry for eight compact symmetric objects (CSOs) taken with the Infrared Spectrograph on the Spitzer Space Telescope. The hosts of these young, powerful radio galaxies show significant diversity in their mid-IR spectra. This includes multiple atomic fine-structure lines, H2 gas, polycyclic aromatic hydrocarbon (PAH) emission, warm dust from T = 50 to150 K, and silicate features in both emission and absorption. There is no evidence in the mid-IR of a single template for CSO hosts, but 5/8 galaxies show similar moderate levels of star formation (<10 M ⊙ yr-1 from PAH emission) and silicate dust in a clumpy torus. The total amount of extinction ranges from AV ∼ 10 to 30, and the high-ionization [Ne V] 14.3 and 24.3 μm transitions are not detected for any galaxy in the sample. Almost all CSOs show contributions both from star formation and active galactic nuclei (AGNs), suggesting that they occupy a continuum between pure starbursts and AGNs. This is consistent with the hypothesis that radio galaxies are created following a galactic merger; the timing of the radio activity onset means that contributions to the IR luminosity from both merger-induced star formation and the central AGN are likely. Bondi accretion is capable of powering the radio jets for almost all CSOs in the sample; the lack of [Ne V] emission suggests an advection-dominated accretion flow mode as a possible candidate. Merging black holes (BHs) with M BH > 108 M ⊙ likely exist …10>
The Northwest Forest Plan: Up To Our Neck In Owls?, Ashley N. Horvat
The Northwest Forest Plan: Up To Our Neck In Owls?, Ashley N. Horvat
Honors Theses
Traversing across the vast Pacific Northwest with the Northern spotted owl (Strix occidentalis caurina), one would experience a dynamic landscape that ranged from areas shrouded with ancient forests, mountains dotted with dense young forests, large swathes of empty habitat from clearcuts, and corridors filled with canopies and a plethora of life. The once vibrant forests that blanketed the Pacific Northwest in an abundance of life and sheltered these rare owls in their canopies were threatened by the removal of these primordial giants in these forests. The wild salmon that journey in record numbers through the cold rivers and …
Determination Of Polymer Molecular Weight Distributions: Dosy, Maldi, Gpc, Nathan A. Meredith
Determination Of Polymer Molecular Weight Distributions: Dosy, Maldi, Gpc, Nathan A. Meredith
Honors Capstone Projects and Theses
No abstract provided.
Synthesis Of Fused Heterocyclic Diamidines For The Treatment Of Human African Trypanosomiasis And Fluorescence Studies Of Selected Diamidines, Jennifer Crystal Brown Barber
Synthesis Of Fused Heterocyclic Diamidines For The Treatment Of Human African Trypanosomiasis And Fluorescence Studies Of Selected Diamidines, Jennifer Crystal Brown Barber
Chemistry Dissertations
A class of linear diamidines was synthesized for the evaluation as a treatment of Human African Trypanosomiasis. These fused heterocyclic compounds are thiazole[5,4-d]thiazoles and are of interest because the parent compound, 2,5-Bis(4-amidinophenyl)-thiazolo[5,4-d]thiazole HCl salt, which is also called DB 1929, has exhibited a low nanomolar IC50 value against Trypanosoma brucei rhodesiense and has shown selectivity for binding to the human telomere G-quadruplex over that of DNA duplex. A fluoro and a methoxy derivative have been synthesized and are currently undergoing testing for activity and binding affinity. In addition, fluorescence studies of selected diamidines were done to study the effect of …
The Optical And Radio Properties Of A Low-Redshift Sample Of Broad-Lined Active Galactic Nuclei, Stephen E. Rafter
The Optical And Radio Properties Of A Low-Redshift Sample Of Broad-Lined Active Galactic Nuclei, Stephen E. Rafter
Physics and Astronomy Dissertations
The question as to whether the distribution of radio loudness in active galactic nuclei (AGN) is actually bimodal has been discussed extensively in the literature. Furthermore, there have been claims that radio loudness depends on black hole mass and Eddington ratio. We investigate these claims using the low redshift broad line AGN sample of Greene & Ho 2007, which consists of 8434 objects at z < 0.35 from the Sloan Digital Sky Survey (SDSS) Fourth Data Release. We obtained radio fluxes from the Very Large Array Faint Images of the Radio Sky at Twenty-Centimeters (FIRST) survey for the SDSS AGN. Out of the 8434 SDSS AGN, 846 have radio emission within 4" of the optical counterpart and are considered to be core emission. We also perform a systematic search for extended emission in FIRST that can be positively associated with the optical counterparts and find 51 out of the 846 previously detected core sources have extended emission that must be taken into account when calculating the total radio luminosity. Further, we find an additional 12 objects that have extended radio emission but no detectable radio core and have classic FR II type morphologies. Using these data, the question of radio bimodality and the dependence of radio-loudness on physical parameters are investigated for different subsets of the total sample. We find modest trends in the radio-loud fraction as a function of black hole mass and Eddington ratio, where the fraction of RL AGN increases for the largest black hole mass group and decreases with increasing Eddington ratio. With extended emission taken into account, we find strong evidence for a bimodal distribution in radio-loudness, where the lower radio luminosity core-only sources appear as a population separate from the extended sources with a dividing line at log(R) = 1.75. This dividing line is interesting in that it requires the radio luminosity to be 50 times the optical luminosity, ensuring that these are indeed the most RL AGN, which may have different or extreme physical conditions in their central engines when compared to the more numerous radio quiet AGN in this sample.
Design, Synthesis And Mechanistic Studies Of Small Molecule Inhibitors Of The Hypoxia Inducible Factor Pathway, Suazette Reid Mooring
Design, Synthesis And Mechanistic Studies Of Small Molecule Inhibitors Of The Hypoxia Inducible Factor Pathway, Suazette Reid Mooring
Chemistry Dissertations
Cancer accounts for nearly one-quarter of deaths in the United States, exceeded only by heart diseases. In 2006, there were 559,888 cancer deaths in the US. Finding effective treatments for cancer is a major challenge among researchers. In solid tumor, hypoxia increases the progression of malignancy and metastasis by promoting angiogenesis. The transcription factor HIF-1 is responsible for the regulation of cellular processes, including glycolysis and angiogenesis. Clinical evidence has determined that expression of HIF-1 is strongly associated with poor patient prognosis. Also, activation of HIF-1 contributes to malignant behavior and therapeutic resistance. In view of these observations, there is …
Evaluation Of Constant Voltage Chamber Modifications, Justin Dekany
Evaluation Of Constant Voltage Chamber Modifications, Justin Dekany
Senior Theses and Projects
Determining the electrical properties of highly insulating materials can be a challenging task. These materials are designed to greatly resist the flow of electrical current making them useful in the construction of spacecraft. Due to the fact that satellites are isolated from ground, charging caused by the plasma environment found in typical orbital radii (1) is of concern to the designers of modern spacecraft (2). The Utah State University Materials Physics Group Constant Voltage Chamber (CVC) has been designed to measure extremely low currents and low conductivity. Over the last five years, many changes have been made to improve the …
Virginia Offshore Wind Studies, July 2007 To March 2010: Final Report, Virginia Coastal Energy Research Consortium, Patrick G. Hatcher, Johathan J. Miles, Kenneth F. Newbold, George M. Hagerman Jr.
Virginia Offshore Wind Studies, July 2007 To March 2010: Final Report, Virginia Coastal Energy Research Consortium, Patrick G. Hatcher, Johathan J. Miles, Kenneth F. Newbold, George M. Hagerman Jr.
Offshore Wind Research
No abstract provided.
Parameter Estimation In Linear-Linear Segmented Regression, Erika Lyn Hernandez
Parameter Estimation In Linear-Linear Segmented Regression, Erika Lyn Hernandez
Theses and Dissertations
Segmented regression is a type of nonlinear regression that allows differing functional forms to be fit over different ranges of the explanatory variable. This paper considers the simple segmented regression case of two linear segments that are constrained to meet, often called the linear-linear model. Parameter estimation in the case where the joinpoint between the regimes is unknown can be tricky. Using a simulation study, four estimators for the parameters of the linear-linear model are evaluated. The bias and mean squared error of the estimators are considered under differing parameter combinations and sample sizes. Parameters estimated in the model are …
Cluster And Classification Analysis Of Fossil Invertebrates Within The Bird Spring Formation, Arrow Canyon, Nevada: Implications For Relative Rise And Fall Of Sea-Level, Scott L. Morris
Theses and Dissertations
Carbonate strata preserve indicators of local marine environments through time. Such indicators often include microfossils that have relatively unique conditions under which they can survive, including light, nutrients, salinity, and especially water temperature. As such, microfossils are environmental proxies. When these microfossils are preserved in the rock record, they constitute key components of depositional facies. Spence et al. (2004, 2007) has proposed several approaches for determining the facies of a given stratigraphic succession based upon these proxies. Cluster analysis can be used to determine microfossil groups that represent specific environmental conditions. Identifying which microfossil groups exist through time can indicate …
Fluctuations And Pattern Formation In Self-Propelled Particles, Shradha Mishra, Aparna Baskaran, M. Cristina Marchetti
Fluctuations And Pattern Formation In Self-Propelled Particles, Shradha Mishra, Aparna Baskaran, M. Cristina Marchetti
Physics - All Scholarship
We consider a coarse-grained description of a system of self-propelled particles given by hydrodynamic equations for the density and polarization fields. We find that the ordered moving or flocking state of the system is unstable to spatial fluctuations beyond a threshold set by the self-propulsion velocity of the individual units. In this region, the system organizes itself into an inhomogeneous state of well-defined propagating stripes of flocking particles interspersed with low density disordered regions. Further, we find that even in the regime where the homogeneous flocking state is stable, the system exhibits large fluctuations in both density and orientational order. …
Consecutive Patterns: From Permutations To Column-Convex Polyominoes And Back, Don Rawlings, Mark Tiefenbruck
Consecutive Patterns: From Permutations To Column-Convex Polyominoes And Back, Don Rawlings, Mark Tiefenbruck
Mathematics
We expose the ties between the consecutive pattern enumeration problems associated with permutations, compositions, column-convex polyominoes, and words. Our perspective allows powerful methods from the contexts of compositions, column-convex polyominoes, and of words to be applied directly to the enumeration of permutations by consecutive patterns. We deduce a host of new consecutive pattern results,including a solution to the (2m+1)-alternating pattern problem on permutations posed by Kitaev.
Observation Of Geo-Neutrinos, G. Bellini, J. Benziger, S. Bonetti, M. Buizza Avanzini, B. Caccianiga, L. Cadonati, F. Calaprice, C. Carraro, A. Chavarria, F. Dalnoki-Veress, D. D'Angelo, S. Davini, H. De Kerret, A. Derbin, A. Etenko, G. Fiorentini, K. Fomenko, D. Franco, C. Galbiati, S. Gazzana, C. Ghiano, M. Giammarchi, M. Goeger-Neff, A. Goretti, E. Guardincerri, S. Hardy, Aldo Ianni, Andrea Ianni, M. Joyce, V. V. Kobychev, Y. Koshio, G. Korga, D. Kryn, M. Laubenstein, M. Leung, T. Lewke, E. Litvinovich, B. Loer, P. Lombardi, L. Ludhova, I. Machulin, S. Manecki, W. Maneschg, G. Manuzio, Q. Meindl, E. Meroni, L. Miramonti, M. Misiaszek, D. Montanari, V. Muratova, L. Oberauer, M. Obolensky, F. Ortica, M. Pallavicini, L. Papp, L. Perasso, S. Perasso, Andrea Pocar, R. S. Raghavan, G. Ranucci, A. Razeto, A. Re, B. Ricci, P. Risso, A. Romani, D. Rountree, A. Sabelnikov, R. Saldanha, C. Salvo, S. Schönert, H. Simgen, M. Skorokhvatov, O. Smirnov, A. Sotnikov, S. Sukhotin, Y. Surorov, R. Tartaglia, G. Testera, D. Vignaud, R. B. Vogelaar, F. Von Feilitzsch, J. Winter, M. Wojcik, A. Wright, M. Wurm, J. Xu, O. Zaimidoroga, S. Zavaterelli, G. Zuzel
Observation Of Geo-Neutrinos, G. Bellini, J. Benziger, S. Bonetti, M. Buizza Avanzini, B. Caccianiga, L. Cadonati, F. Calaprice, C. Carraro, A. Chavarria, F. Dalnoki-Veress, D. D'Angelo, S. Davini, H. De Kerret, A. Derbin, A. Etenko, G. Fiorentini, K. Fomenko, D. Franco, C. Galbiati, S. Gazzana, C. Ghiano, M. Giammarchi, M. Goeger-Neff, A. Goretti, E. Guardincerri, S. Hardy, Aldo Ianni, Andrea Ianni, M. Joyce, V. V. Kobychev, Y. Koshio, G. Korga, D. Kryn, M. Laubenstein, M. Leung, T. Lewke, E. Litvinovich, B. Loer, P. Lombardi, L. Ludhova, I. Machulin, S. Manecki, W. Maneschg, G. Manuzio, Q. Meindl, E. Meroni, L. Miramonti, M. Misiaszek, D. Montanari, V. Muratova, L. Oberauer, M. Obolensky, F. Ortica, M. Pallavicini, L. Papp, L. Perasso, S. Perasso, Andrea Pocar, R. S. Raghavan, G. Ranucci, A. Razeto, A. Re, B. Ricci, P. Risso, A. Romani, D. Rountree, A. Sabelnikov, R. Saldanha, C. Salvo, S. Schönert, H. Simgen, M. Skorokhvatov, O. Smirnov, A. Sotnikov, S. Sukhotin, Y. Surorov, R. Tartaglia, G. Testera, D. Vignaud, R. B. Vogelaar, F. Von Feilitzsch, J. Winter, M. Wojcik, A. Wright, M. Wurm, J. Xu, O. Zaimidoroga, S. Zavaterelli, G. Zuzel
Andrea Pocar
Geo-neutrinos, electron anti-neutrinos produced in β decays of naturally occurring radioactive isotopes in the Earth, are a unique direct probe of our planet's interior. We report the first observation at more than 3σ C.L. of geo-neutrinos, performed with the Borexino detector at Laboratori Nazionali del Gran Sasso. Anti-neutrinos are detected through the neutron inverse β decay reaction. With a 252.6 ton yr fiducial exposure after all selection cuts, we detected 9.9+4.1−3.4(+14.6−8.2) geo-neutrino events, with errors corresponding to a 68.3% (99.73%) C.L. From the View the MathML source profile, the statistical significance of the Borexino geo-neutrino observation corresponds to a 99.997% …
Neuronbank: A Tool For Cataloging Neuronal Circuitry, Paul S. Katz, Robert Calin-Jageman, Akshaye Dhawan, Chad Frederick, Shuman Guo, Rasanjalee Dissanayaka, Naveen Hiremath, Wenjun Ma, Xiuyn Shen, Hsui C. Wang, Hong Yang, Sushil Prasad, Rajshekhar Sunderraman, Ying Zhu
Neuronbank: A Tool For Cataloging Neuronal Circuitry, Paul S. Katz, Robert Calin-Jageman, Akshaye Dhawan, Chad Frederick, Shuman Guo, Rasanjalee Dissanayaka, Naveen Hiremath, Wenjun Ma, Xiuyn Shen, Hsui C. Wang, Hong Yang, Sushil Prasad, Rajshekhar Sunderraman, Ying Zhu
Computer Science Faculty Publications
The basic unit of any nervous system is the neuron. Therefore, understanding the operation of nervous systems ultimately requires an inventory of their constituent neurons and synaptic connectivity, which form neural circuits. The presence of uniquely identifi able neurons or classes of neurons in many invertebrates has facilitated the construction of cellular-level connectivity diagrams that can be generalized across individuals within a species. Homologous neurons can also be recognized across species. Here we describe NeuronBank.org, a web-based tool that we are developing for cataloging, searching, and analyzing neuronal circuitry within and across species. Information from a single species is represented …
Partitioning Of Minimotifs Based On Function With Improved Prediction Accuracy, Sanguthevar Rajasekaran, Tian Mi, Jerlin Camilus Merlin, Aaron Oommen, Patrick R. Gradie, Martin R. Schiller
Partitioning Of Minimotifs Based On Function With Improved Prediction Accuracy, Sanguthevar Rajasekaran, Tian Mi, Jerlin Camilus Merlin, Aaron Oommen, Patrick R. Gradie, Martin R. Schiller
Life Sciences Faculty Research
Background
Minimotifs are short contiguous peptide sequences in proteins that are known to have a function in at least one other protein. One of the principal limitations in minimotif prediction is that false positives limit the usefulness of this approach. As a step toward resolving this problem we have built, implemented, and tested a new data-driven algorithm that reduces false-positive predictions.
Methodology/Principal Findings
Certain domains and minimotifs are known to be strongly associated with a known cellular process or molecular function. Therefore, we hypothesized that by restricting minimotif predictions to those where the minimotif containing protein and target protein have …