Open Access. Powered by Scholars. Published by Universities.®

Physical Sciences and Mathematics Commons

Open Access. Powered by Scholars. Published by Universities.®

2013

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 331 - 360 of 11462

Full-Text Articles in Physical Sciences and Mathematics

Wind Turbine Controls For Farm And Offshore Operation, Zhongzhou Yang Dec 2013

Wind Turbine Controls For Farm And Offshore Operation, Zhongzhou Yang

Theses and Dissertations

Development of advanced control techniques is a critical measure for reducing the cost of energy for wind power generation, in terms of both enhancing energy capture and reducing fatigue load. There are two remarkable trends for wind energy. First, more and more large wind farms are developed in order to reduce the unit-power cost in installation, operation, maintenance and transmission. Second, offshore wind energy has received significant attention when the scarcity of land resource has appeared to be a major bottleneck for next level of wind penetration, especially for Europe and Asia. This dissertation study investigates on several wind turbine …


Introduction To Real Analysis, William F. Trench Dec 2013

Introduction To Real Analysis, William F. Trench

Faculty Authored and Edited Books & CDs

Using a clear and informal approach, this book introduces readers to a rigorous understanding of mathematical analysis and presents challenging math concepts as clearly as possible. This book is intended for those who want to gain an understanding of mathematical analysis and challenging mathematical concepts.


Glacier Slip And Seismicity Induced By Surface Melt, Peter L. Moore, J. Paul Winberry, Neal R. Iverson, Knut A. Christianson, Sridhar Anandakrishnan, Miriam Jackson, Mark E. Mathison, Denis Cohen Dec 2013

Glacier Slip And Seismicity Induced By Surface Melt, Peter L. Moore, J. Paul Winberry, Neal R. Iverson, Knut A. Christianson, Sridhar Anandakrishnan, Miriam Jackson, Mark E. Mathison, Denis Cohen

All Faculty Scholarship for the College of the Sciences

Many of the key processes governing fast glacier flow involve interaction between a glacier and its basal hydrological system, which is hidden from direct observation. Passive seismic monitoring has shown promise as a tool for remotely monitoring basal processes, but lack of glacier-bed access prevents clear understanding of the relationships between subglacial processes and corresponding seismic emissions. Here we describe direct measurements of basal hydrology, sliding, and broadband seismicity made in a unique subglacial facility in Norway during the onset of two summer melt seasons. In the most pronounced of these episodes, rapid delivery of surface meltwater to the bed …


Minerva 2013, The Honors College Dec 2013

Minerva 2013, The Honors College

Minerva

This issue of Minerva includes an article on the opening of Charlie's Terrace in honor of former Honors Dean, Charlie Slavin; a discussion on community engagement in the Honors curriculum and community; an article on the student recipients of the Rezendes Travel Scholarship; and several articles catching up with Honors alumni.


Economic Challenges Facing Kentucky’S Electricity Generation Under Greenhouse Gas Constraints, Energy And Environment Cabinet, Commonwealth Of Kentucky, Department Of Statistics, University Of Kentucky, Center For Applied Energy Research, University Of Kentucky, Pacific Northwest National Laboratory Dec 2013

Economic Challenges Facing Kentucky’S Electricity Generation Under Greenhouse Gas Constraints, Energy And Environment Cabinet, Commonwealth Of Kentucky, Department Of Statistics, University Of Kentucky, Center For Applied Energy Research, University Of Kentucky, Pacific Northwest National Laboratory

Statistics Reports

From the preface:

For the Energy and Environment Cabinet (EEC), which has primacy in administering most federal environmental laws and regulations at the state level, we have to understand the implications of what is arguably one of the most challenging issues to confront us—greenhouse gas (GHG) emissions and their impact on climate change. Efforts to reduce GHG or carbon dioxide (CO2) emissions have moved beyond the point of discussion at the national level, and the United States Supreme Court has ruled that the U.S. Environmental Protection Agency (EPA) has the authority to regulate GHG emissions. Furthermore, while public …


Analysis Of Energy Flow In Us Globec Ecosystems Using End-To-End Models, J. J. Ruzicka, J. H. Steele, S. K. Gaichas, T. Ballerini, D. J. Gifford, R. D. Brodeur, E. E. Hofmann Dec 2013

Analysis Of Energy Flow In Us Globec Ecosystems Using End-To-End Models, J. J. Ruzicka, J. H. Steele, S. K. Gaichas, T. Ballerini, D. J. Gifford, R. D. Brodeur, E. E. Hofmann

CCPO Publications

End-to-end models were constructed to examine and compare the trophic structure and energy flow in coastal shelf ecosystems of four US Global Ocean Ecosystem Dynamics (GLOBEC) study regions: the Northern California Current, the Central Gulf of Alaska, Georges Bank, and the Southwestern Antarctic Peninsula. High-quality data collected on system components and processes over the life of the program were used as input to the models. Although the US GLOBEC program was species-centric, focused on the study of a selected set of target species of ecological or economic importance, we took a broader community-level approach to describe end-to-end energy flow, from …


X-Ray Fluorescence (Xrf) Analyzer - Theory, Utility, And Qa/Qc For Environmental And Commercial Product Samples In Cambodia, Sereyrath Lim Dec 2013

X-Ray Fluorescence (Xrf) Analyzer - Theory, Utility, And Qa/Qc For Environmental And Commercial Product Samples In Cambodia, Sereyrath Lim

Multidisciplinary Studies Theses

Laboratory facilities in developed countries provide a variety of options for analysis of environmental samples and commercial commodities that could impact human health. The same is not true in developing countries and there is a great need to identify technologies that could be used to provide robust, accurate, cost-effective analysis that minimizes the need for extensive technical training. An X-ray Fluorescence (XRF) analyzer seems to be an analytical technique that could be such a tool for developing countries. Therefore, the objective of this thesis was to assess the performance and utility of a handheld, portable XRF unit in analyzing different …


Measurement Of The Differential And Double-Differential Drell-Yan Cross Sections In Proton-Proton Collisions At S√ = 7 Tev, The Cms Collaboration, S. Chatrchyan, V. Khachatryan, Marc M. Baarmand, B. Dorney, Marcus Hohlmann, Himali Kalakhety, Francisco Yumiceva Dec 2013

Measurement Of The Differential And Double-Differential Drell-Yan Cross Sections In Proton-Proton Collisions At S√ = 7 Tev, The Cms Collaboration, S. Chatrchyan, V. Khachatryan, Marc M. Baarmand, B. Dorney, Marcus Hohlmann, Himali Kalakhety, Francisco Yumiceva

Aerospace, Physics, and Space Science Faculty Publications

Measurements of the differential and double-differential Drell-Yan cross sections are presented using an integrated luminosity of 4.5 (4.8) fb−1 in the dimuon (dielectron) channel of proton-proton collision data recorded with the CMS detector at the LHC at s" role="presentation" style="box-sizing: inherit; display: inline; line-height: normal; word-spacing: normal; overflow-wrap: normal; text-wrap: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; padding: 0px; margin: 0px; position: relative;">s√� = 7 TeV. The measured inclusive cross section in the Z-peak region (60–120 GeV) is σ(ℓℓ) = 986.4 ± 0.6 (stat.) ± 5.9 (exp. …


Marine Micro And Macro Faunas Of Holocene Deposits Of Anadolu Hi̇sari (Anatolian Castle, Bosphorus) And The Presence Of Xantho Poressa (Olivi) (Crustacea: Decapoda: Xanthidae), Engin Meri̇ç, Hüsamettin Balkis, Niyazi Avşar, Atike Nazi̇k, Feyza Di̇nçer Dec 2013

Marine Micro And Macro Faunas Of Holocene Deposits Of Anadolu Hi̇sari (Anatolian Castle, Bosphorus) And The Presence Of Xantho Poressa (Olivi) (Crustacea: Decapoda: Xanthidae), Engin Meri̇ç, Hüsamettin Balkis, Niyazi Avşar, Atike Nazi̇k, Feyza Di̇nçer

Bulletin of the Mineral Research and Exploration

The presence of Xantho poressa (Olivi), known as the recent fossil, from Crustacea- Decapoda in Holocene deposits of Anadolu Hisarı has been revealed inthis study. This crab species is known as ranging from Mediterranean Sea to Black Sea and from Canary Islands to Portugal in Northeast Atlantic within depths of 0-15 meters in tidal and shallow subtidal environments. Remnants of broken crab shells with benthic foraminifera, ostracoda, bryozoan, pelecypoda and gastropoda were found in 78 samples which were collected from different levels of 8 of the cores taken from the basement of Küçüksu Palace at the Anadolu Hisarı. It was …


The Tectono-Stratigraphic Features Of Metamorphites In Alacahan-Çeti̇nkaya Region (Kangal, Sivas), Metin Beyazpi̇ri̇nç, Ali Ekber Akçay Dec 2013

The Tectono-Stratigraphic Features Of Metamorphites In Alacahan-Çeti̇nkaya Region (Kangal, Sivas), Metin Beyazpi̇ri̇nç, Ali Ekber Akçay

Bulletin of the Mineral Research and Exploration

The study area covers Alacahan, Çetinkaya and Kangal regions. Allochthonous and autochthonous rock units are present in the region. Metamorphic rocks exposed in the region have been studied in detail as formation and member and have been incorporated into the Bolkardağ Nappe. Bolkardağ nappe which deposited in Late Devonian-Late Cretaceous and metamorphosed in green schist facies, has been distinguished into Late Devonian Düzce formation, Carboniferous Kınalar formation, late Permian Çayderesi formation, (?)Middle/Late Triassic-Cretaceous Kayaköy formation and Cretaceous Karaböğürtlen formation from base to top. The quartzites found at the base of the Kınalar formation and metaconglomerates at the base of the …


The Segment Structure Of Southern Branch Of The North Anatolian Fault And Paleoseismological Behaviour Of The Gemli̇k Fault, Nw Anatolia, Selim Özalp, Ömer Emre, Ahmet Doğan Dec 2013

The Segment Structure Of Southern Branch Of The North Anatolian Fault And Paleoseismological Behaviour Of The Gemli̇k Fault, Nw Anatolia, Selim Özalp, Ömer Emre, Ahmet Doğan

Bulletin of the Mineral Research and Exploration

The North Anatolian Fault (NAF), which is an intra-continental transform fault, is divided
into two branches as Northern and Southern branches in Marmara Region. The southern
branch which separates from each other by rightward stepovers between Bandırma and
Dokurcun valley is formed by three main fault segments as Geyve, İznik and Gemlik from
East to West. The length of fault segments ranges between 40 and 57 km and GPS data in
Southern branch propose a 5 mm/year slip rate. Two surface faulting events were observed
during paleoseismological excavations which had been carried out on 40 km long Gemlik
segment and …


First Determination Of Rudists (Bivalvia) From Ne Iraq: Systematic Palaeontology And Palaeobiogeography, Sacit Özer, Kamal Haji Karim, Dereen Mohamad Sadiq Dec 2013

First Determination Of Rudists (Bivalvia) From Ne Iraq: Systematic Palaeontology And Palaeobiogeography, Sacit Özer, Kamal Haji Karim, Dereen Mohamad Sadiq

Bulletin of the Mineral Research and Exploration

The Maastrichtian Aqra Formation around Mawat-Chwarta (Sulaimaniya city) in NE Iraq consists mainly of coarse grained detrital limestone, locally containing terrigenous clastics, and is characterized by abundant rudists in life position. The rudist biostromes are very common in the formation and benthic foraminifers, gastropods and non-rudist bivalves with scarcer echinoderms and solitary corals are associated with the rudists. This first determination of rudists from NE Iraq recognizes the following species, Dictyoptychus aff. morgani, Sauvagesia somalica, Hippurites cornucopiae, Praeradiolites subtoucasi and Lapeirousia jouanneti, as well as some indeterminable radiolitid sections. This rudist fauna is assigned to the Hippurites cornucopiae interval zone …


Organic Geochemical And Petrographic Properties Of Hazro Dadaş (Di̇yarbakir) Coals, Orhan Kavak, Selami Toprak Dec 2013

Organic Geochemical And Petrographic Properties Of Hazro Dadaş (Di̇yarbakir) Coals, Orhan Kavak, Selami Toprak

Bulletin of the Mineral Research and Exploration

This study was carried out in Hazro-Dadaş (Diyarbakır) region which owns the only coal basin in the area. Chemical, petrographic analysis and organic geochemical evaluations of the Permian aged coals were taken into consideration. Coal quality investigation along with proximate (moisture, volatile matter, fixed carbon, ash) and elemental analyses (C, H, O, and S, N) were performed and revealed. The huminite reflectance of organically abundant matter and coal levels were found to be between 0.458 and 1.141 %. This parameter complies with fluorescence colors, calorific value (average original 3165 – 3432 Kcal/kg) and average Tmax (418 oC). Hasbro coals show …


A New Medium To High Enthalpy Geothermal Field In Aegean Region (Akyar) Menderes – Seferi̇hi̇sar – İzmi̇r, Western Anatolia, Turkey, Metin Bulut Dec 2013

A New Medium To High Enthalpy Geothermal Field In Aegean Region (Akyar) Menderes – Seferi̇hi̇sar – İzmi̇r, Western Anatolia, Turkey, Metin Bulut

Bulletin of the Mineral Research and Exploration

This study was performed considering that low to medium enthalpy geothermal areas are important besides the geothermal fields with high temperature located in Western Anatolia for heating, thermal tourism and agricultural applications. It was also aimed at obtaining fluids at high temperature in areas which were observed at a temperature relatively lower than the surface temperature. The study area is located at a region between the towns of Menderes and Seferihisar to the south-southwest of Izmir. This is a multidisciplinary investigation which obtained fluids and studied the geothermal energy potential of the area. Field studies were finalized carrying out geological …


Brief Note On New Data Related To The Chronostratigraphic Location Of Cumaovasi Volcanics, Fikret Göktaş Dec 2013

Brief Note On New Data Related To The Chronostratigraphic Location Of Cumaovasi Volcanics, Fikret Göktaş

Bulletin of the Mineral Research and Exploration

-


The Airborne Magnetic Signature Of Gökova Gulf, Uğur Akin, Ahmet Üçer Dec 2013

The Airborne Magnetic Signature Of Gökova Gulf, Uğur Akin, Ahmet Üçer

Bulletin of the Mineral Research and Exploration

Gökova gulf situated in the Aegian extension zone in Turkey has been considered very interesting for numerous research workers. Gökova gulf is located in the N-S regional extentional tectonic regime. N-S extension of western Anatolia initiated development of E-W extended grabens here. The bay extends 100 km E-W and 25 km N-S directions. Datça peninsula is in the south, Bodrum peninsula is located in the north of the Gökova gulf. In recent years ‘Full Tensor Gradiometer Potential Field’ methods (FTG) has found a practice area in between the gravimetric and magnetic methods. In the past as it was in the …


Slope Instability In Open Pits And An Example Of A Retrospective Analysis: Afşi̇n-Elbi̇stan-Kişlaköy Open Pit Coal Deposit, İbrahim Akbulut, İlker Çam, Tahsin Aksoy, Dinçer Çağlan, Tolga Ölmez Dec 2013

Slope Instability In Open Pits And An Example Of A Retrospective Analysis: Afşi̇n-Elbi̇stan-Kişlaköy Open Pit Coal Deposit, İbrahim Akbulut, İlker Çam, Tahsin Aksoy, Dinçer Çağlan, Tolga Ölmez

Bulletin of the Mineral Research and Exploration

The subject of this study is to study the instabilities that have developed in the permanent east and west slopes of the Kışlaköy open pit of the Elektrik Üretim A.Ş. Afşin-Elbistan Linyitleri İşletmesi and to work out the sliding mechanism causing it. In the Kışlaköy open pit to establish if mass movement is continuing and if so which direction it would move, amount of mass to be involved and the failing model. Six movement control observations stations were established along 3 lines in each of west and east slopes. No movement was observed in the west slopes. On the other …


Original Findings On The Ore-Bearing Facies Of Volcanogenic Massive Sulphide Deposits In The Eastern Black Sea Region (Ne Turkey), M.Kemal Revan, Yurdal Genç, V. Valery Maslennikov, Taner Ünlü, Okan Deli̇baş, Semi Hamzaçebi̇ Dec 2013

Original Findings On The Ore-Bearing Facies Of Volcanogenic Massive Sulphide Deposits In The Eastern Black Sea Region (Ne Turkey), M.Kemal Revan, Yurdal Genç, V. Valery Maslennikov, Taner Ünlü, Okan Deli̇baş, Semi Hamzaçebi̇

Bulletin of the Mineral Research and Exploration

In the massive sulphide deposits of the eastern Black Sea region, there are ore facies and ore-bearing sedimentary facies. The former are subdivided into hydrothermal-metasomatic, seafloor hydrothermal, and biological facies. Hydrothermal-metasomatic facies refer to sub-seafloor processes and include network-disseminated, massive vein, and massive lens facies. The precipitation of sulphide minerals within pre-existing volcano-sedimentary rocks occurs largely beneath the seafloor, and these ores form an important component of some deposits. The term seafloor hydrothermal facies refers to sulphide accumulation on the seafloor and is characterised by hydrothermal chimneys and clastic sulphide ores. Clastic sulphide ores can be subdivided into proximal and …


New Approaches On The Investigation Of Covered Geothermal Fields: Exploration Of Kütahya – Şaphane – Karacaderbent Buried Geothermal Fields And Their Developments, Musa Burçak, Hüseyin Dünya, Ömer Hacisali̇hoğlu Dec 2013

New Approaches On The Investigation Of Covered Geothermal Fields: Exploration Of Kütahya – Şaphane – Karacaderbent Buried Geothermal Fields And Their Developments, Musa Burçak, Hüseyin Dünya, Ömer Hacisali̇hoğlu

Bulletin of the Mineral Research and Exploration

The basement in Şaphane region is constituted by Paleozoic gneiss, schist and marbles belonging to northern margin of the Menderes Massif. These basement rocks are overlain by Cretaceous aged Dağardı ophiolitic melange. All these rocks are discordantly covered by Neogene – Quaternary sedimentary and volcanic rocks deposited under lacustrine – continental environments. The main purpose of this study is to explore buried geothermal system on a covered area using geological, geophysical and geochemical methods and to develop this system by drilling investigations. Geological, geophysical, geochemical and drilling investigations, well development and test studies were applied in this research. This study …


Development And Application Of A Gis-Based Long Island Sound Eelgrass Habitat Suitability Index Model, Jamie M.P. Vaudrey, Justin Eddings, Christopher Pickerell, Lorne Brousseau, Charles Yarish Dec 2013

Development And Application Of A Gis-Based Long Island Sound Eelgrass Habitat Suitability Index Model, Jamie M.P. Vaudrey, Justin Eddings, Christopher Pickerell, Lorne Brousseau, Charles Yarish

Department of Marine Sciences

The primary objectives of the Eelgrass Habitat Suitability Index Model (EHSI Model) are to assist in the evaluation of sites being considered for eelgrass restoration efforts in the Long Island Sound (LIS) area and to identify areas where water quality issues reduce or eliminate the potential for natural eelgrass colonization. To achieve this goal, geospatial processing of data available from the Long Island Sound area was conducted using ArcGIS v10.0 including the 3D Analyst and Spatial Analyst extensions. The result is a series of maps presented in this report and a GIS-based model available for users to interact with the …


Identification Of Disufide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle Dec 2013

Identification Of Disufide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle

Michael Menze

MitoNEET is a protein that was identified as a drug target for diabetes, but its cellular function as well as its role in diabetes remains elusive. Protein pull-down experiments identified glutamate dehydrogenase 1 (GDH1) as a potential binding partner. GDH1 is a key metabolic enzyme with emerging roles in insulin regulation. MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator. Proteomic analysis identified the specific cysteine residues that participate in the disulfide bond. This is the first report that effectively links mitoNEET to activation of the insulin regulator GDH1.


Weak Covering Properties And Selection Principles, L. Babinkostova, B. A. Pansera, Marion Scheepers Dec 2013

Weak Covering Properties And Selection Principles, L. Babinkostova, B. A. Pansera, Marion Scheepers

Mathematics Faculty Publications and Presentations

No convenient internal characterization of spaces that are productively Lindelöf is known. Perhaps the best general result known is Alsterʼs internal characterization, under the Continuum Hypothesis, of productively Lindelöf spaces which have a basis of cardinality at most 1. It turns out that topological spaces having Alsterʼs property are also productively weakly Lindelöf. The weakly Lindelöf spaces form a much larger class of spaces than the Lindelöf spaces. In many instances spaces having Alsterʼs property satisfy a seemingly stronger version of Alsterʼs property and consequently are productively X, where X is a covering property stronger than the …


Astrophobia: A 3d Multiplayer Space Combat Game With Linear Entity Interpolation, Luke Larson Dec 2013

Astrophobia: A 3d Multiplayer Space Combat Game With Linear Entity Interpolation, Luke Larson

Computer Science and Software Engineering

Astrophobia is a Descent-like 3D networked multiplayer space combat game with linear entity interpolation (client-side animation between game-state packets to give the illusion of continuous game updates) similar to entity interpolation implemented in Valve Software’s Source engine. Additionally, Astrophobia procedurally generates unique levels, has zero-gravity physics, ship and projectile wall bouncing, hit detection, OpenGL 3D graphics, Phong lighting, ship model and texture, and a simple HUD that provides visualization of health points, aiming crosshair, and player scoreboard.


Reconstructing Point Clouds Of Mid-Size Objects, Spencer Woodworth Dec 2013

Reconstructing Point Clouds Of Mid-Size Objects, Spencer Woodworth

Computer Science and Software Engineering

This project explores the use of an inexpensive 3D camera for the acquisition and reconstruction of mid-size objects. The disparity of objects between stereo image pairs are used to calculate depth and generate a depth map. The depth map is used to generate a point cloud representation of the object from a single view. Finally, point clouds are generated from several views of an object and then aligned and merged into a seamless 360-degree point cloud.


Sustainable Development And The Issue Of Water In The Kagera Region Of Tanzania, Teresa M. Dresner Dec 2013

Sustainable Development And The Issue Of Water In The Kagera Region Of Tanzania, Teresa M. Dresner

Theses & Dissertations

Over the last five decades, an abundance of research on sustainable development has emerged in multiple disciplinary areas, but few studies on the economic, social, and environmental dimensions of sustainability have examined water issues for rural communities. Consequently, the purpose of this case study was to understand how a group of rural women from the Kagera region in Tanzania perceived and experienced sustainable development as a result of their improved access to water. The following central questions of the study sought to explore the local meanings of sustainable development and improved water sources: (a) How was life of rural women …


A New Approach To The Numerical Solution Of Fractional Order Optimal Control Problems, T. Akbarian, M. Keyanpour Dec 2013

A New Approach To The Numerical Solution Of Fractional Order Optimal Control Problems, T. Akbarian, M. Keyanpour

Applications and Applied Mathematics: An International Journal (AAM)

In this article, a new numerical method is proposed for solving a class of fractional order optimal control problems. The fractional derivative is considered in the Caputo sense. This approach is based on a combination of the perturbation homotopy and parameterization methods. The control function u(t) is approximated by polynomial functions with unknown coefficients. This method converts the fractional order optimal control problem to an optimization problem. Numerical results are included to demonstrate the validity and applicability of the method.


Graphic Illustration Of The Transmission Resonances For The Dkp Particles, B. Boutabia-Chéraitia, Abdenacer Makhlouf Dec 2013

Graphic Illustration Of The Transmission Resonances For The Dkp Particles, B. Boutabia-Chéraitia, Abdenacer Makhlouf

Applications and Applied Mathematics: An International Journal (AAM)

We consider the Duffin-Kemmer-Petiau (DKP) equation in the presence of a spatially one-dimensional Woods-Saxon (WS) potential and we show by graphics how the zero-reflection condition on the Klein interval depends on the shape of the potential.


Exponentially Fitted Variants Of The Two-Step Adams-Bashforth Method For The Numerical Integration Of Initial Problems, Gurjinder Singh, V. Kanwar, Saurabh Bhatia Dec 2013

Exponentially Fitted Variants Of The Two-Step Adams-Bashforth Method For The Numerical Integration Of Initial Problems, Gurjinder Singh, V. Kanwar, Saurabh Bhatia

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, we propose new variants of the two-step Adams-Bashforth and the one-step Adams-Moulton methods for the numerical integration of ordinary differential equations (ODEs). The methods are constructed geometrically from an exponentially fitted osculating parabola. The accuracy and stability of the proposed variants is discussed and their applicability to some initial value problems is also considered. Numerical experiments demonstrate that the exponentially fitted variants of the two-step Adams-Bashforth and the one-step Adams-Moulton methods outperform the existing classical two-step Adams-Bashforth and one-step Adams- Moulton methods respectively.


Targeting Inflammation Using Salsalate In Patients With Type 2 Diabetes: Effects On Flow-Mediated Dilation (Tinsal-Fmd)., Allison B Goldfine, J Stewart Buck, Cyrus Desouza, Vivian Fonseca, Yii-Der Ida Chen, Steven E Shoelson, Kathleen A. Jablonski, Mark A Creager, The Tinsal-Fmd Team Dec 2013

Targeting Inflammation Using Salsalate In Patients With Type 2 Diabetes: Effects On Flow-Mediated Dilation (Tinsal-Fmd)., Allison B Goldfine, J Stewart Buck, Cyrus Desouza, Vivian Fonseca, Yii-Der Ida Chen, Steven E Shoelson, Kathleen A. Jablonski, Mark A Creager, The Tinsal-Fmd Team

GW Biostatistics Center

OBJECTIVE: To test whether inhibiting inflammation with salsalate improves endothelial function in patients with type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS: We conducted an ancillary study to the National Institutes of Health-sponsored, multicenter, randomized, double-masked, placebo-controlled trial evaluating the safety and efficacy of salsalate in targeting inflammation to improve glycemia in patients with T2D. Flow-mediated, endothelium-dependent dilation (FMD) and endothelium-independent, nitroglycerin-mediated dilation (NMD) of the brachial artery were assessed at baseline and 3 and 6 months following randomization to either salsalate 3.5 g/day or placebo. The primary end point was change in FMD at 6 months.

RESULTS: A total …


Multiple Hypotheses Testing Procedures In Clinical Trials And Genomic Studies, Qing Pan Dec 2013

Multiple Hypotheses Testing Procedures In Clinical Trials And Genomic Studies, Qing Pan

Epidemiology Faculty Publications

We review and compare multiple hypothesis testing procedures used in clinical trials and those in genomic studies. Clinical trials often employ global tests, which draw an overall conclusion for all the hypotheses, such as SUM test, Two-Step test, Approximate Likelihood Ratio test (ALRT), Intersection-Union Test (IUT), and MAX test. The SUM and Two-Step tests are most powerful under homogeneous treatment effects, while the ALRT and MAX test are robust in cases with non-homogeneous treatment effects. Furthermore, the ALRT is robust to unequal sample sizes in testing different hypotheses. In genomic studies, stepwise procedures are used to draw marker-specific conclusions and …