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2015

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Articles 1831 - 1860 of 12617

Full-Text Articles in Physical Sciences and Mathematics

Augmented Happy Functions Of Higher Powers, Marcus Harbol, Breeanne B. Swart Oct 2015

Augmented Happy Functions Of Higher Powers, Marcus Harbol, Breeanne B. Swart

Journal of the South Carolina Academy of Science

No abstract provided.


Solving Simple Japanese Ladder Games, Christopher Rufty, Wei-Kai Lai Oct 2015

Solving Simple Japanese Ladder Games, Christopher Rufty, Wei-Kai Lai

Journal of the South Carolina Academy of Science

In this article we introduce a simpler version of Japanese ladder game. The mathematics of this game is discussed and an algebraic method is also introduced to solve this game.


Generation Of A Novel Exactly Solvable Potential, Jonathan Bougie, Asim Gangopadhyaya, Jeffry V. Mallow, Emeritus, Constantin Rasinariu Oct 2015

Generation Of A Novel Exactly Solvable Potential, Jonathan Bougie, Asim Gangopadhyaya, Jeffry V. Mallow, Emeritus, Constantin Rasinariu

Physics: Faculty Publications and Other Works

We report a new shape-invariant (SI) isospectral extension of the Morse potential. Previous investigations have shown that the list of “conventional” SI superpotentials that do not depend explicitly on Planck's constant ħ is complete. Additionally, a set of “extended” superpotentials has been identified, each containing a conventional superpotential as a kernel and additional ħ-dependent terms. We use the partial differential equations satisfied by all SI superpotentials to find a SI extension of Morse with novel properties. It has the same eigenenergies as Morse but different asymptotic limits, and does not conform to the standard generating structure for isospectral deformations.


Dendrochronological Analysis Of The Martin Cabin Oct 2015

Dendrochronological Analysis Of The Martin Cabin

Historic Structures

Dating historical structures using dendrochronology. The Historical Structures collection consists of reports that are the result of dendochronological analysis of timbers from structures in Pennsylvania and Ohio. Contributors: Bell, Brandon; Farr, Katherine; Wiesenberg, Nicholas; Wiles, Greg


The Nicotine Metabolite, Cotinine, Alters The Assembly And Trafficking Of A Subset Of Nicotinic Acetylcholine Receptors, Ashley M. Fox, Faruk H. Moonschi, Christopher I. Richards Oct 2015

The Nicotine Metabolite, Cotinine, Alters The Assembly And Trafficking Of A Subset Of Nicotinic Acetylcholine Receptors, Ashley M. Fox, Faruk H. Moonschi, Christopher I. Richards

Chemistry Faculty Publications

Exposure to nicotine alters the trafficking and assembly of nicotinic receptors (nAChRs), leading to their up-regulation on the plasma membrane. Although the mechanism is not fully understood, nicotine-induced up-regulation is believed to contribute to nicotine addiction. The effect of cotinine, the primary metabolite of nicotine, on nAChR trafficking and assembly has not been extensively investigated. We utilize a pH-sensitive variant of GFP, super ecliptic pHluorin, to differentiate between intracellular nAChRs and those expressed on the plasma membrane to quantify changes resulting from cotinine and nicotine exposure. Similar to nicotine, exposure to cotinine increases the number of α4β2 receptors on the …


Effects Of Oil-Contaminated Sediments On Submerged Vegetation: An Experimental Assessment Of Ruppia Maritima, Charles W. Martin, Lauris O. Hollis, R. Eugene Turner Oct 2015

Effects Of Oil-Contaminated Sediments On Submerged Vegetation: An Experimental Assessment Of Ruppia Maritima, Charles W. Martin, Lauris O. Hollis, R. Eugene Turner

Faculty Publications

Oil spills threaten the productivity of ecosystems through the degradation of coastal flora and the ecosystem services these plants provide. While lab and field investigations have quantified the response of numerous species of emergent vegetation to oil, the effects on submerged vegetation remain uncertain. Here, we discuss the implications of oil exposure for Ruppia maritima, one of the most common species of submerged vegetation found in the region affected by the recent Deepwater Horizon oil spill. We grew R. maritima in a range of manipulated sediment oil concentrations: 0, 0.26, 0.53, and 1.05 mL oil /L tank volume, and tracked …


Know Tommorrow Brown University Poster, Shepard Fairey, Risd Archives Oct 2015

Know Tommorrow Brown University Poster, Shepard Fairey, Risd Archives

Ecology and Environment

Poster for Brown University student event to demand action to counter climate change. "Brown emPOWER is joining dozens of colleges across the country for Know Tomorrow, a national day of action to raise awareness about climate change and its consequences. 2015 is the year for climate action as world leaders meet for the UN climate talks in Paris to sign a global agreement on climate. On October 2nd, join us for an evening of live music, engaging speakers, and environmental action on the Main Green at Brown University! Featuring: Kerry Kennedy, What Cheer? Brigade, Voces Verdes- Latino Leadership in …


First Observation Of The Hadronic Transition Υ(4s)→Ηhb(1p)And New Measurement Of The Hb(1p) And Ηb(1s) Parameters, U. Tamponi, R. Mussa, A. Abdesselam, H. Aihara, K. Arinstein, D. Joffe Oct 2015

First Observation Of The Hadronic Transition Υ(4s)→Ηhb(1p)And New Measurement Of The Hb(1p) And Ηb(1s) Parameters, U. Tamponi, R. Mussa, A. Abdesselam, H. Aihara, K. Arinstein, D. Joffe

Faculty Articles

Using a sample of 771.6×106 ΥΥ(4S) decays collected by the Belle experiment at the KEKB e+e− collider, we observe, for the first time, the transition Υ(4S)→ηhb(1P) with the branching fraction B[Υ(4S)→ηhb(1P)]=(2.18±0.11±0.18)×10−3 and we measure the hb(1P) mass Mhb(1P)=(9899.3±0.4±1.0)  MeV/c2, corresponding to the hyperfine (HF) splitting ΔMHF(1P)=(0.6±0.4±1.0)  MeV/c2. Using the transition hb(1P)→γηb(1S), we measure the ηb(1S) mass Mηb(1S)=(9400.7±1.7±1.6)  MeV/c2, corresponding to ΔMHF(1S)=(59.6±1.7±1.6)  MeV/c2, the ηb(1S) width Γηb(1S)=(8+6−5±5)  MeV/c2and the branching fraction B[hb(1P)→γηb(1S)]=(56±8±4)%.


First Observation Of The Hadronic Transition Υ(4s)→Ηhb(1p) And New Measurement Of The Hb(1p) And Ηb(1s) Parameters, U. Tamponi Et Al Oct 2015

First Observation Of The Hadronic Transition Υ(4s)→Ηhb(1p) And New Measurement Of The Hb(1p) And Ηb(1s) Parameters, U. Tamponi Et Al

Faculty Articles

Using a sample of 771.6×106 ΥΥ(4S) decays collected by the Belle experiment at the KEKB e+e− collider, we observe, for the first time, the transition Υ(4S)→ηhb(1P) with the branching fraction B[Υ(4S)→ηhb(1P)]=(2.18±0.11±0.18)×10−3 and we measure the hb(1P) mass Mhb(1P)=(9899.3±0.4±1.0)  MeV/c2, corresponding to the hyperfine (HF) splitting ΔMHF(1P)=(0.6±0.4±1.0)  MeV/c2. Using the transition hb(1P)→γηb(1S), we measure the ηb(1S) mass Mηb(1S)=(9400.7±1.7±1.6)  MeV/c2, corresponding to ΔMHF(1S)=(59.6±1.7±1.6)  MeV/c2, the ηb(1S) width Γηb(1S)=(8+6−5±5)  MeV/c2 and the branching fraction B[hb(1P)→γηb(1S)]=(56±8±4)%.


Modeling Continental Shelf Formation In The Adriatic Sea And Elsewhere, Lincoln Pratson, John Swenson Oct 2015

Modeling Continental Shelf Formation In The Adriatic Sea And Elsewhere, Lincoln Pratson, John Swenson

VIMS Articles

No abstract provided.


Data Science In Statistics Curricula: Preparing Students To “Think With Data”, J. Hardin, R. Hoerl, Nicholas J. Horton, D. Nolan, B. Baumer, O. Hall-Holt, P. Murrell, R. Peng, P. Roback, D. Temple Lang, M. D. Ward Oct 2015

Data Science In Statistics Curricula: Preparing Students To “Think With Data”, J. Hardin, R. Hoerl, Nicholas J. Horton, D. Nolan, B. Baumer, O. Hall-Holt, P. Murrell, R. Peng, P. Roback, D. Temple Lang, M. D. Ward

Statistical and Data Sciences: Faculty Publications

A growing number of students are completing undergraduate degrees in statistics and entering the workforce as data analysts. In these positions, they are expected to understand how to use databases and other data warehouses, scrape data from Internet sources, program solutions to complex problems in multiple languages, and think algorithmically as well as statistically. These data science topics have not traditionally been a major component of undergraduate programs in statistics. Consequently, a curricular shift is needed to address additional learning outcomes. The goal of this article is to motivate the importance of data science proficiency and to provide examples and …


Interannual And Subdecadal Variability In The Nutrient Geochemistry Of The Cariaco Basin, Mary I. Scranton, Gordon T. Taylor, Robert Thunell, Claudia R. Benitez-Nelson, Frank Muller-Karger, Kent Fanning, Laura Lorenzoni, Enrique Montes, Ramon Varela, Yrene Astor Oct 2015

Interannual And Subdecadal Variability In The Nutrient Geochemistry Of The Cariaco Basin, Mary I. Scranton, Gordon T. Taylor, Robert Thunell, Claudia R. Benitez-Nelson, Frank Muller-Karger, Kent Fanning, Laura Lorenzoni, Enrique Montes, Ramon Varela, Yrene Astor

Faculty Publications

The CARIACO Ocean Time Series program has made monthly measurements of oxygen, nutrients, and carbon system parameters (∑CO2, alkalinity, pH) in the Cariaco Basin since 1996. At the same time, sediment traps have collected settling particles at four to five depths ranging from 150 to 1,200 m. The depth of the transition from oxic to anoxic conditions has fluctuated dramatically over the time series due to changes in the occurrence of Caribbean water intrusions into the deep basin. Nutrient concentrations in the deep basin have increased steadily with time in a proportion reflective of the elemental ratios in the settling …


Mid-Infrared Optical Frequency Combs Based On Difference Frequency Generation For Molecular Spectroscopy, Flavio C. Cruz, Daniel L. Maser, Todd Johnson, Gabriel Ycas, Andrew Klose, Fabrizio R. Giorgetta, Ian Coddington, Scott A. Diddams Oct 2015

Mid-Infrared Optical Frequency Combs Based On Difference Frequency Generation For Molecular Spectroscopy, Flavio C. Cruz, Daniel L. Maser, Todd Johnson, Gabriel Ycas, Andrew Klose, Fabrizio R. Giorgetta, Ian Coddington, Scott A. Diddams

Physics Faculty Publications

Mid-infrared femtosecond optical frequency combs were produced by difference frequency generation of the spectral components of a near-infrared comb in a 3-mm-long MgO:PPLN crystal. We observe strong pump depletion and 9.3 dB parametric gain in the 1.5 μm signal, which yields powers above 500 mW (3 μW/mode) in the idler with spectra covering 2.8 μm to 3.5 μm. Potential for broadband, high-resolution molecular spectroscopy is demonstrated by absorption spectra and interferograms obtained by heterodyning two combs.


Factors Controlling The Composition And Lithofacies Characteristics Of The Paleoproterozoic Bar River Formation, Huronian Supergroup, Rohan Dj Aranha Oct 2015

Factors Controlling The Composition And Lithofacies Characteristics Of The Paleoproterozoic Bar River Formation, Huronian Supergroup, Rohan Dj Aranha

Electronic Thesis and Dissertation Repository

The Bar River Formation of the Paleoproterozoic Huronian Supergroup is one of the earliest sedimentary formations deposited following Earth’s Great Oxidation Event. Ten quartz-rich lithofacies were identified near Flack Lake, Ontario. Lithofacies associations resemble multiple, stacked tidal inlet fill sequences, common to mesotidal shorelines. Sedimentary structures, such as herringbone cross-stratification, reactivation surfaces, and wave ripples, support tidal and wave action. Paleocurrent patterns are bimodal to polymodal with a mean paleoflow to the southeast. Potential sources northwest of the study area include Archean Superior Province rocks and the Paleoproterozoic Lorrain Formation. Major and trace element, and oxygen isotope geochemistry support either …


Water Current, Volume 47, No. 4, Fall 2015 Oct 2015

Water Current, Volume 47, No. 4, Fall 2015

Water Current Newsletter

Study: Two Major U.S. Aquifers Have High Levels of Natural Uranium

Water Advanced Research and Innovation Fellowship Program (WARI)


Reconnaissance Surveying Using Satellite-Derived Bathymetry, Shachak Pe'eri, Patrick Keown, Michael Gonsalves Oct 2015

Reconnaissance Surveying Using Satellite-Derived Bathymetry, Shachak Pe'eri, Patrick Keown, Michael Gonsalves

Center for Coastal and Ocean Mapping

False Pass, AK, USA, is the eastern-most passage through the Aleutian Islands between the Bering Sea and the Pacific Ocean and provides a passage for small to mid-size vessels. The passage is considered an alternative route to Unimak Pass, AK for vessels from mainland Alaska and is estimated to be shorter by 160 to 240km. False Pass is closed every winter due to sea-ice cover that freezes the inlet system around OctoberNovember and melts only towards the spring (around March). As a result, the soft sediment of the seafloor contains mud and sand that may change the path of the …


Empirical Investigation Of Key Business Factors For Digital Game Performance, Saiqa Aleem, Luiz Fernando Capretz, Faheem Ahmed Oct 2015

Empirical Investigation Of Key Business Factors For Digital Game Performance, Saiqa Aleem, Luiz Fernando Capretz, Faheem Ahmed

Electrical and Computer Engineering Publications

Game development is an interdisciplinary concept that embraces software engineering, business, management, and artistic disciplines. This research facilitates a better understanding of the business dimension of digital games. The main objective of this research is to investigate empirically the effect of business factors on the performance of digital games in the market and to answer the research questions asked in this study. Game development organizations are facing high pressure and competition in the digital game industry. Business has become a crucial dimension, especially for game development organizations. The main contribution of this paper is to investigate empirically the influence of …


Topography And Tropical Cyclone Structure Influence On Eyewall Evolution In Typhoon Sinlaku (2008), Cheng-Hsiang Chih, Kun-Hsuan Chou, Sen Chiao Oct 2015

Topography And Tropical Cyclone Structure Influence On Eyewall Evolution In Typhoon Sinlaku (2008), Cheng-Hsiang Chih, Kun-Hsuan Chou, Sen Chiao

Faculty Publications, Meteorology and Climate Science

Typhoon Sinlaku (2008) was a tropical system that affected many countries in East Asia. Besides the loss of life and economic damage, many scientific questions are associated with this system that need to be addressed. A series of numerical simulations were conducted in this study using V3.2 of the advanced research version of the Weather Research and Forecasting (WRF-ARW) model to examine the impacts of different terrain conditions and vortex structures on the eyewall evolution when Sinlaku was crossing Taiwan. The sensitivity experiments using different vortex structures show that a storm of the same intensity with a larger eyewall radius …


Mutations Of Adjacent Amino Acid Pairs Are Not Always Independent, Jyotsna Ramanan, Peter Revesz Oct 2015

Mutations Of Adjacent Amino Acid Pairs Are Not Always Independent, Jyotsna Ramanan, Peter Revesz

CSE Conference and Workshop Papers

Evolutionary studies usually assume that the genetic mutations are independent of each other. This paper tests the independence hypothesis for genetic mutations with regard to protein coding regions. According to the new experimental results the independence assumption generally holds, but there are certain exceptions. In particular, the coding regions that represent two adjacent amino acids seem to change in ways that sometimes deviate significantly from the expected theoretical probability under the independence assumption.


A Computational Translation Of The Phaistos Disk, Peter Revesz Oct 2015

A Computational Translation Of The Phaistos Disk, Peter Revesz

CSE Conference and Workshop Papers

For over a century the text of the Phaistos Disk remained an enigma without a convincing translation. This paper presents a novel semi-automatic translation method that uses for the first time a recently discovered connection between the Phaistos Disk symbols and other ancient scripts, including the Old Hungarian alphabet. The connection between the Phaistos Disk script and the Old Hungarian alphabet suggested the possibility that the Phaistos Disk language may be related to Proto-Finno-Ugric, Proto-Ugric, or Proto-Hungarian. Using words and suffixes from those languages, it is possible to translate the Phaistos Disk text as an ancient sun hymn, possibly connected …


A Computational Model Of The Spread Of Ancient Human Populations Based On Mitochondrial Dna Samples, Peter Revesz Oct 2015

A Computational Model Of The Spread Of Ancient Human Populations Based On Mitochondrial Dna Samples, Peter Revesz

CSE Conference and Workshop Papers

The extraction of mitochondrial DNA (mtDNA) from ancient human population samples provides important data for the reconstruction of population influences, spread and evolution from the Neolithic to the present. This paper presents a mtDNA-based similarity measure between pairs of human populations and a computational model for the evolution of human populations. In a computational experiment, the paper studies the mtDNA information from five Neolithic and Bronze Age populations, namely the Andronovo, the Bell Beaker, the Minoan, the Rössen and the Únětice populations. In the past these populations were identified as separate cultural groups based on geographic location, age and the …


A-Maze-D: Advanced Maze Development Kit Using Constraint Databases, Shruti Daggumarti, Peter Revesz, Corey Svehla Oct 2015

A-Maze-D: Advanced Maze Development Kit Using Constraint Databases, Shruti Daggumarti, Peter Revesz, Corey Svehla

CSE Conference and Workshop Papers

In this paper, we describe the A-Maze-D system which shows that constraint databases can be applied conveniently and efficiently to the design of maze games. A-Maze-D provides a versatile set of features by a combination of a MATLAB library and the MLPQ constraint database system. A-Maze-D is the first system that uses constraint databases to build maze games and opens new ideas in video game development.


Mathematics In Contemporary Society Chapter 1, Patrick J. Wallach Oct 2015

Mathematics In Contemporary Society Chapter 1, Patrick J. Wallach

Open Educational Resources

Mathematics in Contemporary Society is the textbook that corresponds to MA-321, the course of the same name. The course is designed to provide students with mathematical ideas and methods found in the social sciences, the arts, and in business. Topics will include fundamentals of statistics, scatterplots, graphics in the media, problem solving strategies, dimensional analysis, mathematics in music and art, and mathematical modeling. EXCEL is used to explore real world applications.

The textbook was posted in weekly installments:


Mathematics In Contemporary Society Chapter 7, Patrick J. Wallach Oct 2015

Mathematics In Contemporary Society Chapter 7, Patrick J. Wallach

Open Educational Resources

Mathematics in Contemporary Society is the textbook that corresponds to MA-321, the course of the same name. The course is designed to provide students with mathematical ideas and methods found in the social sciences, the arts, and in business. Topics will include fundamentals of statistics, scatterplots, graphics in the media, problem solving strategies, dimensional analysis, mathematics in music and art, and mathematical modeling. EXCEL is used to explore real world applications.

The textbook was posted in weekly installments:


Mathematics In Contemporary Society Chapter 10, Patrick J. Wallach Oct 2015

Mathematics In Contemporary Society Chapter 10, Patrick J. Wallach

Open Educational Resources

Mathematics in Contemporary Society is the textbook that corresponds to MA-321, the course of the same name. The course is designed to provide students with mathematical ideas and methods found in the social sciences, the arts, and in business. Topics will include fundamentals of statistics, scatterplots, graphics in the media, problem solving strategies, dimensional analysis, mathematics in music and art, and mathematical modeling. EXCEL is used to explore real world applications.

The textbook was posted in weekly installments:


Mathematics In Contemporary Society Chapter 9, Patrick J. Wallach Oct 2015

Mathematics In Contemporary Society Chapter 9, Patrick J. Wallach

Open Educational Resources

Mathematics in Contemporary Society is the textbook that corresponds to MA-321, the course of the same name. The course is designed to provide students with mathematical ideas and methods found in the social sciences, the arts, and in business. Topics will include fundamentals of statistics, scatterplots, graphics in the media, problem solving strategies, dimensional analysis, mathematics in music and art, and mathematical modeling. EXCEL is used to explore real world applications.

The textbook was posted in weekly installments:


Mathematics In Contemporary Society Chapter 8, Patrick J. Wallach Oct 2015

Mathematics In Contemporary Society Chapter 8, Patrick J. Wallach

Open Educational Resources

Mathematics in Contemporary Society is the textbook that corresponds to MA-321, the course of the same name. The course is designed to provide students with mathematical ideas and methods found in the social sciences, the arts, and in business. Topics will include fundamentals of statistics, scatterplots, graphics in the media, problem solving strategies, dimensional analysis, mathematics in music and art, and mathematical modeling. EXCEL is used to explore real world applications.

The textbook was posted in weekly installments:


A New Taeniolabidoid Multituberculate (Mammalia) From The Middle Puercan Of The Nacimiento Formation, New Mexico, And A Revision Of Taeniolabidoid Systematics And Phylogeny, Thomas E. Williamson, Stephen L. Brusatte, Ross Secord, Sarah Shelley Oct 2015

A New Taeniolabidoid Multituberculate (Mammalia) From The Middle Puercan Of The Nacimiento Formation, New Mexico, And A Revision Of Taeniolabidoid Systematics And Phylogeny, Thomas E. Williamson, Stephen L. Brusatte, Ross Secord, Sarah Shelley

Department of Earth and Atmospheric Sciences: Faculty Publications

Multituberculates were amongst the most abundant and taxonomically diverse mammals of the late Mesozoic and the Paleocene, reaching their zenith in diversity and body size in the Paleocene. Taeniolabidoidea, the topic of this paper, includes the largest known multituberculates, which possess highly complex cheek teeth adapted for herbivory. A new specimen from the early Paleocene (middle Puercan; biochron Pu2) of the Nacimiento Formation, New Mexico represents a new large-bodied taeniolabidoid genus and species, Kimbetopsalis simmonsae. A phylogenetic analysis to examine the relationships within Taeniolabidoidea that includes new information from Kimbetopsalis gen. et sp. nov. and gen. nov. and …


Comparison Of The Crystal Structures Of 4,4′-Bis­­[3-(4-Methyl­Piperidin-1-Yl)Prop-1-Yn-1-Yl]-1,1′-Bi­Phenyl And 4,4′-Bis­­[3-(2,2,6,6-Tetra­Methyl­Piperidin-1-Yl)Prop-1-Yn-1-Yl]-1,1′-Biphen­Yl, Anqi Wan, Narsimha Reddy Penthala, E. Kim Fifer, Sean Parkin, Peter A. Crooks Oct 2015

Comparison Of The Crystal Structures Of 4,4′-Bis­­[3-(4-Methyl­Piperidin-1-Yl)Prop-1-Yn-1-Yl]-1,1′-Bi­Phenyl And 4,4′-Bis­­[3-(2,2,6,6-Tetra­Methyl­Piperidin-1-Yl)Prop-1-Yn-1-Yl]-1,1′-Biphen­Yl, Anqi Wan, Narsimha Reddy Penthala, E. Kim Fifer, Sean Parkin, Peter A. Crooks

Chemistry Faculty Publications

As part of a comprehensive program to discover α9α10 nicotinic acetyl­choline receptor antagonists, the title compounds C30H36N2, (I), and C36H48N2, (II), were synthesized by coupling 4,4′-bis­(3-bromo­prop-1-yn-1-yl)-1,1′-biphenyl with 4-methyl­piperidine and 2,2,6,6-tetra­methyl­piperidine, respectively, in aceto­nitrile at room temperature. In compound (I), the biphenyl system has a twisted conformation with a dihedral angle of 26.57 (6)° between the two phenyl rings of the biphenyl moiety, while in compound (II), the biphenyl moiety sits on a crystallographic inversion centre so the two phenyl rings are exactly coplanar. The terminal piperidine rings in …


Comparison Crystal Structure Conformations Of Two Structurally Related Biphenyl Analogues: 4,4'-Bis[3-(Pyrrolidin-1-Yl)Prop-1-Yn-1-Yl]-1,1'-Biphenyl And 4,4'-Bis{3-[(S)-2-Methylpyrrolidin-1-Yl]Prop-1-Yn-1-Yl}-1,1'-Biphenyl, Anqi Wan, Narsimha Reddy Penthala, E. Kim Fifer, Sean Parkin, Peter A. Crooks Oct 2015

Comparison Crystal Structure Conformations Of Two Structurally Related Biphenyl Analogues: 4,4'-Bis[3-(Pyrrolidin-1-Yl)Prop-1-Yn-1-Yl]-1,1'-Biphenyl And 4,4'-Bis{3-[(S)-2-Methylpyrrolidin-1-Yl]Prop-1-Yn-1-Yl}-1,1'-Biphenyl, Anqi Wan, Narsimha Reddy Penthala, E. Kim Fifer, Sean Parkin, Peter A. Crooks

Chemistry Faculty Publications

The title compounds, C26H28N2, (I), and C28H32N2, (II), were designed based on the structure of the potent 910 nicotinic acetyl­choline receptor antagonist ZZ161C {1,1'-[[1,1'-biphen­yl]-4,4'-diylbis(prop-2-yne-3,1-di­yl)]bis­(3,4-di­methyl­pyridin-1-ium) bromide}. In order to improve the druglikeness properties of ZZ161C for potential oral administration, the title compounds (I) and (II) were prepared by coupling 4,4'-bis­(3-bromo­prop-1-yn-1-yl)-1,1'-biphenyl with pyrrol­idine, (I), and (S)-2-methyl­pyrrolidine, (II), respectively, in aceto­nitrile at room temperature. The asymmetric unit of (I) contains two half mol­ecules that each sit on sites of crystallographic inversion. As a result, the biphenyl ring systems in …