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2017

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Articles 12211 - 12240 of 12521

Full-Text Articles in Physical Sciences and Mathematics

Pathways And Supply Of Dissolved Iron In The Amundsen Sea (Antarctica), P. St-Laurent, P. L. Yager, R. M. Sherrell, S. E. Stammerjohn, M. S. Dinniman Jan 2017

Pathways And Supply Of Dissolved Iron In The Amundsen Sea (Antarctica), P. St-Laurent, P. L. Yager, R. M. Sherrell, S. E. Stammerjohn, M. S. Dinniman

CCPO Publications

Numerous coastal polynyas fringe the Antarctic continent and strongly influence the productivity of Antarctic shelf systems. Of the 46 Antarctic coastal polynyas documented in a recent study, the Amundsen Sea Polynya (ASP) stands out as having the highest net primary production per unit area. Incubation experiments suggest that this productivity is partly controlled by the availability of dissolved iron (dFe).As a first step toward understanding the iron supply of the ASP, we introduce four plausible sources of dFe and simulate their steady spatial distribution using conservative numerical tracers. The modeled distributions replicate important features from observations including dFe maxima at …


Understanding Community Character As A Socio-Ecological Framework To Enhance Local-Scale Adaptation: An Interdisciplinary Case Study From Rural Northwest Connecticut, Joanna Wozniak-Brown Jan 2017

Understanding Community Character As A Socio-Ecological Framework To Enhance Local-Scale Adaptation: An Interdisciplinary Case Study From Rural Northwest Connecticut, Joanna Wozniak-Brown

Antioch University Dissertations & Theses

Around the world, municipalities are facing new challenges, not the least of which is climate change. This is especially true for rural communities that, for a variety of reasons, will be disproportionately affected by the climatic changes and accompanying policies or programs.

This dissertation, written in manuscript-style, integrates climate change and social-ecological scholarship to address the unique character of rural communities, to communicate the complexity of rural identity through the term "rural character"; and to empower rural communities to incorporate adaptation strategies into their daily municipal operations and planning.

Specifically, this dissertation seeks to answer the following questions: What is …


Hanover County, Virginia - Shoreline Inventory Report: Methods And Guidelines, Marcia Berman, Karinna Nunez, Sharon Killeen, Tamia Rudnicky, Julie Bradshaw, Karen Duhring, Kallie Brown, Jessica Hendricks, David Weiss, Carl Hershner Jan 2017

Hanover County, Virginia - Shoreline Inventory Report: Methods And Guidelines, Marcia Berman, Karinna Nunez, Sharon Killeen, Tamia Rudnicky, Julie Bradshaw, Karen Duhring, Kallie Brown, Jessica Hendricks, David Weiss, Carl Hershner

Reports

The 2017 Inventory for Hanover County was generated using on-screen, digitizing techniques in ArcGIS® -ArcMap v10.4.1while viewing conditions observed in Bing high resolution oblique imagery, Google Earth, and 2013 imagery from the Virginia Base Mapping Program (VBMP).Four GIS shapefiles are developed.The first describes land use and bank conditions (Hanover _lubc_2017). The second portrays the presence of beaches (Hanover _beaches_2017). The third reports shoreline structures that are described as arcs or lines(e.g. riprap)(Hanover _sstru_2017). The final shapefile includes all structures that are represented as points(e.g. piers)(Hanover _astru_2017).The metadata file accompanies the shapefiles and defines attribute accuracy, data development, and any use …


King George County, Virginia Shoreline Inventory Report: Methods And Guidelines, Marcia Berman, Karinna Nunez, Sharon Killeen, Tamia Rudnicky, Julie Bradshaw, Karen Duhring, Kallie Brown, Jessica Hendricks, Kory Angstadt, David Weiss, Carl Hershner Jan 2017

King George County, Virginia Shoreline Inventory Report: Methods And Guidelines, Marcia Berman, Karinna Nunez, Sharon Killeen, Tamia Rudnicky, Julie Bradshaw, Karen Duhring, Kallie Brown, Jessica Hendricks, Kory Angstadt, David Weiss, Carl Hershner

Reports

Disclaimer:

The Center for Coastal Resources Management (CCRM) provides these data with the understanding that they are not guaranteed to be correct or complete, and conclusions drawn from the data set are the sole responsibility of the user. Every attempt has been made to ensure that these data and the documentation are reliable and accurate. CCRM, the Virginia Institute of Marine Science (VIMS), and the Commonwealth of Virginia assume no liability for any damages caused by inaccuracies in the data or documentation; and make no warranty, express or implied, as to the accuracy, completeness, or utility of this information, nor …


County Of Spotsylvania, Virginia - Shoreline Inventory Report: Methods And Guidelines, Marcia Berman, Karinna Nunez, Tamia Rudnicky, Julie Bradshaw, Karen Duhring, Kallie Brown, Jessica Hendricks, David Weiss, Carl Hershner Jan 2017

County Of Spotsylvania, Virginia - Shoreline Inventory Report: Methods And Guidelines, Marcia Berman, Karinna Nunez, Tamia Rudnicky, Julie Bradshaw, Karen Duhring, Kallie Brown, Jessica Hendricks, David Weiss, Carl Hershner

Reports

The 2017Inventory for Spotsylvania County was generated using on-screen, digitizing techniques in ArcGIS® -ArcMap v10.4.1while viewing conditions observed in Bing high resolution oblique imagery, Google Earth, and2013imagery from the Virginia Base Mapping Program (VBMP).FourGIS shapefiles are developed.The first describes land use and bank conditions (Spotsylvania_lubc_2017). The second portrays the presence of beaches (Spotsylvania_beaches_2017). The third reports shoreline structures that are described as arcs or lines(e.g. riprap)(Spotsylvania_sstru_2017). The final shapefile includes all structures that are represented as points(e.g. piers)(Spotsylvania_astru_2017).The metadata file accompanies the shapefiles and defines attribute accuracy, data development, and any use restrictions that pertain to data.


The County Of Isle Of Wight, Virginia Shoreline Inventory Report: Summary Tables, Marcia Berman, Karinna Nunez, Tamia Rudnicky, Julie Bradshaw, Karen Duhring, Kallie Brown, Jessica Hendricks, David Stanhope, Kory Angstadt, Christine Tombleson, David Weiss, Carl Hershner Jan 2017

The County Of Isle Of Wight, Virginia Shoreline Inventory Report: Summary Tables, Marcia Berman, Karinna Nunez, Tamia Rudnicky, Julie Bradshaw, Karen Duhring, Kallie Brown, Jessica Hendricks, David Stanhope, Kory Angstadt, Christine Tombleson, David Weiss, Carl Hershner

Reports

The Shoreline Inventory Summary Tables quantify observed conditions based on river systems, such as the combined length of linear features (e.g. shoreline miles surveyed, miles of bulkhead and revetment), the total number of point features (e.g. docks, boathouses, boat ramps) & total acres of polygon features (tidal marshes).


Power Budgets For Cubesat Radios To Support Ground Communications And Inter-Satellite Links, Otilia Popescu Jan 2017

Power Budgets For Cubesat Radios To Support Ground Communications And Inter-Satellite Links, Otilia Popescu

Engineering Technology Faculty Publications

CubeSats are a class of pico-satellites that have emerged over the past decade as a cost-effective alternative to the traditional large satellites to provide space experimentation capabilities to universities and other types of small enterprises, which otherwise would be unable to carry them out due to cost constraints. An important consideration when planning CubeSat missions is the power budget required by the radio communication subsystem, which enables a CubeSat to exchange information with ground stations and/or other CubeSats in orbit. The power that a CubeSat can dedicate to the communication subsystem is limited by the hard constraints on the total …


Error Aggregation In The Reengineering Process From 3d Scanning To Printing, Jennifer G. Michaeli, Matthew C. Degroff, Roman C. Roxas Jan 2017

Error Aggregation In The Reengineering Process From 3d Scanning To Printing, Jennifer G. Michaeli, Matthew C. Degroff, Roman C. Roxas

Engineering Technology Faculty Publications

This work aims to study the aggregation of dimensional errors in the reengineering processes using 3D scanning and printing without initial design drawings. A 57-tooth spur gear is used as an example to facilitate the discussion. Two approaches are investigated. The first one builds the gear model based upon measurement taken from a caliper, and the second approach uses a 3D scanner to collect geometry data. Dimensional errors in each stage of these two approaches are investigated. Particular attention is paid to the geometry data flow in the reengineering process from data acquisition and editing to model construction. Recommendations are …


Mechanisms For Cross-Scaling, Flexibility And Social Learning In Building Resilience To Sea Level Rise: Case Study Of Hampton Roads, Virginia, Carol Considine, Michelle Covi, Juita-Elena (Wie) Yusuf Jan 2017

Mechanisms For Cross-Scaling, Flexibility And Social Learning In Building Resilience To Sea Level Rise: Case Study Of Hampton Roads, Virginia, Carol Considine, Michelle Covi, Juita-Elena (Wie) Yusuf

Engineering Technology Faculty Publications

This case study examines how the Hampton Roads Sea Level Rise Preparedness and Resilience Intergovernmental Planning Pilot Project, a whole-of-government and whole-of-community approach to planning for and adapting to sea level rise, addressed coastal resilience in a southeastern Virginia watershed that spans multiple jurisdictions. Meeting the challenge of sea level rise requires that actors across multiple sectors—citizens, community organizations, industry and government—understand the risks and work together to make critical decisions regarding adaptation strategies and actions. The case study area includes Little Creek Amphibious Base, which is bordered by the cities of Norfolk and Virginia Beach. Adaptation responses to sea …


Green Infrastructure Training For Veterans, Carol L. Considine, Michael W. Seek, Jon Lester, Anthony W. Dean Jan 2017

Green Infrastructure Training For Veterans, Carol L. Considine, Michael W. Seek, Jon Lester, Anthony W. Dean

Engineering Technology Faculty Publications

The Environmental Protection Agency launched a Strategic Agenda to Protect Waters and Build More Livable Communities through Green Infrastructure in April of 2011. This initiative supports local communities in using green infrastructure to manage rain water while creating co-benefits of green space, which makes communities more attractive and livable. (EPA) In the fall of 2014 the Environmental Protection Agency along with the U.S. Department of Agriculture, U.S. Department of Defense, U.S. Department of Energy, U.S. Department of Housing and Urban Development, U.S. Department of the Interior and U.S. Department of Transportation signed a federal letter of support for green infrastructure …


Nebraska Statewide Groundwater-Level Monitoring Report 2016, Aaron R. Young, Mark E. Burbach, Leslie M. Howard, Michele M. Waszgis, R. Matthew Joeckel, Sue Olafsen Lackey Jan 2017

Nebraska Statewide Groundwater-Level Monitoring Report 2016, Aaron R. Young, Mark E. Burbach, Leslie M. Howard, Michele M. Waszgis, R. Matthew Joeckel, Sue Olafsen Lackey

Conservation and Survey Division

The term “groundwater” has come to be all but synonymous with Nebraska. Nearly three-quarters of the volume of the High Plains aquifer lies beneath the State, and groundwater maintains our streams, our ecosystems, our people, and our vitally important agricultural economy. Although Nebraska’s total groundwater resource is vast, it is also quite vulnerable to changes induced by natural processes and by humankind, necessitating a long-term commitment to wise management through informed decision making. Monitoring, studying, and reporting are the essential basis for such management and, ultimately, for meeting the myriad challenges presented by change.

The personnel of the Conservation and …


2016 Nebraska Water Leaders Academy - Final Report, Mark E. Burbach, Connie Reimers-Hild Jan 2017

2016 Nebraska Water Leaders Academy - Final Report, Mark E. Burbach, Connie Reimers-Hild

Conservation and Survey Division

The effective management of Nebraska’s water resources is evermore challenged by variations in weather, climate, technology, socioeconomic policies, and regulation. Anthropogenic climate change, declining water tables and stream flows, increasing demands on freshwater, aging water infrastructure, fiscal constraints, and impacts on aquatic organisms are particularly imminent challenges in Nebraska and around the world (Pahl-Wostl et al., 2013; Pittock et al., 2008; USACE, 2010). Sustaining freshwater ecosystem services in the face of emerging environmental threats presents an immense societal dilemma worldwide (Pittock et al., 2013; Rockström et al., 2009, Millenium Ecosystem Assessment, 2005). The rapidly changing conditions of water resources in …


Holocene Fault Reactivation And Landscape Evolution In The Eastern Cascades, Wa, Benjamin M. Carlson Jan 2017

Holocene Fault Reactivation And Landscape Evolution In The Eastern Cascades, Wa, Benjamin M. Carlson

WWU Graduate School Collection

Significant uncertainty remains in how and where modest, distributed shortening is accommodated throughout the eastern Cascade Range in Washington State. Using lidar imagery, I identified a ~5 km long lineament in Swakane Canyon near Wenatchee, roughly coincident with a strand of the Entiat fault. Topographic profiles show the lineament is formed by a southwest-side-up break in slope with between 2 and 42 m of vertical separation of the ground surface. Trenching reveals deformed saprolite and colluvium consistent with southwest-side-up folding caused by blind reverse faulting at depth. Radiocarbon and luminescence dating combined with stratigraphic constraints suggest up to three Holocene …


Changes In Water Chemistry And Biological Communities Associated With Metal Mining In Streams In The North Cascades, Brooke G. Bannerman Jan 2017

Changes In Water Chemistry And Biological Communities Associated With Metal Mining In Streams In The North Cascades, Brooke G. Bannerman

WWU Graduate School Collection

Hard rock and placer mining have been occurring throughout the mountains in the northern portion of Washington State since the late-1800s. As a result, aquatic ecosystems in this region are susceptible to the physical, chemical and biological changes that result from mining activities. These alterations, which include changes in water chemistry, habitat modifications, and reduction or contamination of food sources, can adversely impact aquatic communities of periphyton, benthic macroinvertebrates and fish. To evaluate changes in water chemistry and biological communities in two regions with extensive mining histories, the Ruby Creek watershed and Upper Skagit River watershed, I analyzed metals in …


Mothers' Roots Curriculum Project, Sonya Gobert Jan 2017

Mothers' Roots Curriculum Project, Sonya Gobert

WWU Graduate School Collection

Since time immemorial, Indigenous mothers have taught their children how to survive in Indigenous way of being. When we remind our daughters of the strength, and the generations of resiliency and self-love before them, is when we will see real change. The truth is, when we teach our children their identity, we are giving them the tools to restore and rebuild their roots. These children are then the seeds which will be planted with the promise to grow in the awareness of true sovereignty, nationhood, and self-empowerment steeped in Indigenous truth which will ultimately trickle down in their own parenting …


A Theoretical And Experimental Study Into The Kinetics Of Solution Phase Thin Film Deposition, Cyrus Schaaf Jan 2017

A Theoretical And Experimental Study Into The Kinetics Of Solution Phase Thin Film Deposition, Cyrus Schaaf

WWU Graduate School Collection

The performance of electronic and optoelectronic devices based on solution-processed organic semiconductor layers is strongly influenced by their mesoscale polycrystalline structure, including domain size and spatial distributions. In solution-processed films prepared by spin casting, solvent-based printing, and related methods, morphology is governed by a combination of interrelated thermodynamic and kinetic factors. Classical models of crystal formation in bulk solution or on bare surfaces in vacuum-deposited films fail to adequately capture these effects; the current theoretical understanding of crystallization in solution-deposited films is generally unable to provide much insight, let alone predictive design guidance for tailoring films with specific structural characteristics …


Structural Evolution Of The San Juan Thrust System, Orcas And Shaw Islands, Wa, Kevin Quillan Jan 2017

Structural Evolution Of The San Juan Thrust System, Orcas And Shaw Islands, Wa, Kevin Quillan

WWU Graduate School Collection

The San Juan Thrust System represents the western elements of the Cascades orogen and preserves evidence for Cretaceous Cordilleran margin tectonics. The kinematics of deformation phases and their temporal relationship to accretionary wedge high-pressure low-temperature metamorphism remains uncertain. The structural and metamorphic evolution of the San Juan Thrust System was studied on Orcas and Shaw Islands in Western Washington. Detailed field mapping indicates that a widespread S1 flattening fabric (formed during D1) is subparallel to and cut by an S2 fabric found within brittle-ductile shear zones that bound the terranes (formed during D2). Post-cleavage brittle structures (formed during D3) offset …


Probing The Catalytic Properties Of Ni-Based Bimetallic Phosphides For Deep Hydrodesulfurization, Peter J. Topalian Jan 2017

Probing The Catalytic Properties Of Ni-Based Bimetallic Phosphides For Deep Hydrodesulfurization, Peter J. Topalian

WWU Graduate School Collection

Global demand for transportation fuels continues to rise while environmental standards for sulfur impurities in fuels have become more stringent. Upgrading crude oil feed stocks via deep hydrodesulfurization (HDS) is necessary to meet the ultra-low sulfur standards for transportation fuels. Transition metal phosphides (e.g. Ni2P, Ru2P) represents a new class of hydrotreating catalysts that show promise for improved HDS properties relative to conventional molybdenum sulfide based catalysts. Incorporating a second metal into Ni2P can influence the surface properties and be used to tailor the catalytic properties (activity, selectivity) for improved hydrotreating performance. Bimetallic phosphides …


Modeling, Design And Fabrication Of Biocompatible Silk-Based Electronics And Actuators, Nicholas Ostrovsky-Snider Jan 2017

Modeling, Design And Fabrication Of Biocompatible Silk-Based Electronics And Actuators, Nicholas Ostrovsky-Snider

WWU Graduate School Collection

Biocompatible actuators are widely desired for a variety of biomedical devices such as micromanipulators, steerable catheters and artificial muscles but current devices have shortcomings in the range of motion they can achieve. Biocompatible electrodes made from conducting polymers (CPs) have been successfully created but achieving the spatial patterning of these polymers needed for electronic devices like strain gauges, stimulation electrodes and micro circuitry has been difficult. Previous work has relied on complex chemical incorporation of CPs into photoresists or electropolymerization onto vapor-deposited metal substrates. A simple method to produce metal-free flexible electronics would be highly desirable for biomedical electronics. This …


A Computational Investigation Of Bodipy Excited State Properties And Photosensitization Of Molecular Oxygen, Keenan Komoto Jan 2017

A Computational Investigation Of Bodipy Excited State Properties And Photosensitization Of Molecular Oxygen, Keenan Komoto

WWU Graduate School Collection

Cancer has long been a significant problem that has affected our world’s population for years and continues to this day. With the number of cases expected to increase annually there is a societal pressure to find effective treatment methods for eliminating cancer. Current forms of cancer treatment tend to cause detrimental effects to the human body and are usually quite expensive and long lasting, some costing upwards of $30,000 over an 8 week period. A more recently established form of cancer treatment known as photodynamic therapy is an effective treatment option for ridding cancers that lie on or just below …


Interpreting The Dynamics Of Submarine Landslides Through Hydroacoustic Modeling, West Mata Volcano, Ne Lau Basin, Jonathan G. Drobiarz Jan 2017

Interpreting The Dynamics Of Submarine Landslides Through Hydroacoustic Modeling, West Mata Volcano, Ne Lau Basin, Jonathan G. Drobiarz

WWU Graduate School Collection

Landslides are an integral process in the development of submarine volcanoes, but these events are rarely recorded and observed. Therefore, understanding how the morphology of volcanoes evolve requires information on landslides. Hydroacoustic signals were analyzed for the purposes of characterizing frequent landslides on West Mata volcano during a 5-month eruptive period. Over 200 landslide signals have been compared in conjunction with hydroacoustic modeling to better understand the dynamics that control them. We used interference patterns produced by multipath rays to identify and model these slope failures. Landslides were most clearly captured on the north and west stations, suggesting a source …


Effectiveness Of Salmon Carcass Analogs As A Form Of Nutrient Enhancement For Juvenile Coho Salmon (Oncorhynchus Kisutch) In Three Lower Columbia Watersheds, Matthew T. Sturza Jan 2017

Effectiveness Of Salmon Carcass Analogs As A Form Of Nutrient Enhancement For Juvenile Coho Salmon (Oncorhynchus Kisutch) In Three Lower Columbia Watersheds, Matthew T. Sturza

WWU Graduate School Collection

Adult Pacific salmon exhibit a form of parental care after spawning and perishing by depositing a subsidy of marine derived nutrients (MDN) that may be incorporated into the stream food web and feed juvenile salmon. Adult salmon populations have significantly declined since the late 19th century, thereby reducing the amount of MDN within Pacific Northwest Streams. This loss in nutrients within stream food webs may be limiting the growth and survival of juvenile salmon and therefore reducing the population sizes of adult salmon. One strategy to mitigate for nutrient deficiencies within a stream is the use of salmon carcass analogs …


Testing The Time Dependence Of Slip On The Western Klamath Lake Fault Zone, Oregon, Gunnar Speth Jan 2017

Testing The Time Dependence Of Slip On The Western Klamath Lake Fault Zone, Oregon, Gunnar Speth

WWU Graduate School Collection

New geomorphic mapping and cosmogenic 3He geochronology on the Western Klamath Lake fault zone in southern Oregon reveals moderate, but resolvable changes in the rate of normal-fault slip rates over the past ~170 kyr. We focus on a sequence of glacial and post-glacial surfaces that record progressive offset by the fault zone over multiple time intervals. Thirty-nine new cosmogenic 3He surface exposure dates and a cosmogenic nuclide depth profile establish the first late-Pleistocene glacial chronology in the Cascade Range of Oregon and constrains the timing of the last two major glacial advances in the region at 17.6 ± 2.1 …


Plant Community And Nutrient Development Within Four Estuary Restoration Sites In Kitsap County, Washington, Shannon M. (Shannon Marie) Call Jan 2017

Plant Community And Nutrient Development Within Four Estuary Restoration Sites In Kitsap County, Washington, Shannon M. (Shannon Marie) Call

WWU Graduate School Collection

Coastal wetland ecosystems are some of the most productive ecosystems on the planet and link freshwater and marine environments. Coastal wetlands provide invaluable ecosystem services such as carbon sequestration, storm abatement, biogeochemical cycling, and water filtration. However, estuaries affected by physical barriers, such as culverts, experience reduced hydrological inputs and reduced connectivity above and below the site of impact. Loss of connectivity results in loss of ecosystem function such as carbon and nitrogen cycling. We investigated soil nutrients and vegetation composition of estuarine communities in four estuary restoration locations in Kitsap County, Washington and the following questions were addressed: 1) …


Do Conspecific Soil Microorganisms Inhibit Potentilla Recta?, Faythe Duran Jan 2017

Do Conspecific Soil Microorganisms Inhibit Potentilla Recta?, Faythe Duran

WWU Graduate School Collection

In the U.S., Potentilla recta is an invasive, exotic forb. Previous research suggests that the soil microbes of native congeners (relatives within the same genus as P. recta) may inhibit P. recta, presumably because phylogenetically similar species may culture and be susceptible to similar pathogens. Our study aimed to answer three questions: (1) how do the fungal communities within the roots of P. recta compare to the fungal communities within the roots of neighboring congeners Potentilla gracilis and Drymocallis glandulosa (hereinafter referred to as the congeners) and native forbs, (2) what are the effects of the whole microbial …


Intermolecular Interactions That Lead To The Activation And Inhibition Of Ribosome-Dependent Gtpases, Amanda J. Weis Jan 2017

Intermolecular Interactions That Lead To The Activation And Inhibition Of Ribosome-Dependent Gtpases, Amanda J. Weis

WWU Graduate School Collection

Ribosomes are the macromolecular machines responsible for protein synthesis across all domains of life. Translation of genetic information into a polypeptide by ribosomes is facilitated by a multitude of proteins called translation factors, many of which belong to the guanosine 5’ triphosphate hydrolase (GTPase) superfamily that utilize the hydrolysis of GTP to exert their function. Many naturally occurring antibiotics inhibit protein biosynthesis by targeting the bacterial ribosome or associated translation factors and with increasing antibiotic resistance due to bacterial evolution, the importance of studying ribosome-translation factor interactions is amplified. Determination of high-resolution structures of the ribosome has significantly bolstered our …


Building Arc Crust – Plutonic To Volcanic Connections In An Extensional Island Arc, The Alisitos Arc Crustal Section (Southern Rosario Segment), Baja California, Rebecca A. (Rebecca Anne) Morris Jan 2017

Building Arc Crust – Plutonic To Volcanic Connections In An Extensional Island Arc, The Alisitos Arc Crustal Section (Southern Rosario Segment), Baja California, Rebecca A. (Rebecca Anne) Morris

WWU Graduate School Collection

The southern volcano-bounded basin of the Rosario segment of the Cretaceous Alisitos oceanic arc provides outstanding 3-D exposures of the upper 7 km of an extensional arc, where crustal generation processes are recorded in the upper crustal volcanic rocks and underlying plutonic rocks. These exceptional exposures allow for the study of the physical and chemical links between the rock units, and helps constrain the differentiation processes active during the growth and evolution of the arc.

Upper crustal volcanic rocks comprise a 3-5 km thick volcanic-volcaniclastic stratigraphy with shallow sill and dike intrusions. Coarse-grained plutonic rocks intrude these units over a …


Towards The Substrate-Bound Structure Of Streptococcus Pneumoniae Sortase A, Orion Banks Jan 2017

Towards The Substrate-Bound Structure Of Streptococcus Pneumoniae Sortase A, Orion Banks

WWU Graduate School Collection

Bacterial sortases have been widely studied for their usefulness in protein modification, however, the variable substrate specificity and activity between homologs of these enzymes is not yet fully characterized. To attempt to further understand sorting signal recognition, we have made advances towards a substrate bound structure of Streptococcus pneumoniae sortase A (SrtApneu). This enzyme displays a wide tolerance for alternate amino acids within the canonical LPXTG sorting motif. Our strategy involves a non-cleavable peptide analog that can be docked into the active site, allowing for elucidation of a structure displaying the key contacts that allow the enzyme to …


Clustering Of Epigenetic Methylation And Oxidative Damage: Effects On Duplex Dna Solution Structure, Thermodynamic Stability And Local Dynamics, David R. Gruber Jan 2017

Clustering Of Epigenetic Methylation And Oxidative Damage: Effects On Duplex Dna Solution Structure, Thermodynamic Stability And Local Dynamics, David R. Gruber

WWU Graduate School Collection

All known living organisms use DNA to store genetic templates used for development, proper function and reproduction. The structural integrity of DNA is therefore of extreme importance and cellular machinery continuously regulates our DNA either through addition of covalent molecules to regulate the transcription of genes or the removal of DNA lesions propagating from the exposure to reactive molecules. One of the most common DNA lesions, 8-oxoguanine (8OG), is a prominent, pro-mutagenic DNA adduct present at a baseline level from consistent generation of reactive oxygen species through oxidative metabolism or at greater concentrations through exposure to ionizing radiation and …


Probing The Secondary Coordination Sphere Of Zn(Ii) And Fe(Ii) Pyridinediimine (Pdi) Complexes, Mayra Delgado Jan 2017

Probing The Secondary Coordination Sphere Of Zn(Ii) And Fe(Ii) Pyridinediimine (Pdi) Complexes, Mayra Delgado

WWU Graduate School Collection

The transformation of many small, abundant molecules is necessary both in a biological setting and in the chemical industry. In Nature, the activation of small molecules is promoted by metalloenzymes. However, many of these chemical transformations are thermodynamically demanding and consist of multi-electron redox processes. Understanding the secondary coordination sphere has played an integral role in determining the catalytic activity and selectivity of such transformations and has led to the development of bioinspired catalysts in order to mimic the native active site of the metalloenzyme. Due to its extensive modularity, the utilization of the pyridinediimine (PDI) metal complexes was targeted …