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2017

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Articles 151 - 180 of 12520

Full-Text Articles in Physical Sciences and Mathematics

Of Rats And Men, Thomas S. Walsh Dec 2017

Of Rats And Men, Thomas S. Walsh

Capstones

This capstone is a data-driven investigation into New York City's rat problem. By using publicly available government data to map rat activity in NYC, I identified several socio-economic variables that correlate with rat populations at the community district, borough, and city-scale. I used these findings (mainly that rat problems are linked to lower incomes) as the basis of an investigation, which includes interviews with residents, experts, and city officials. Prof. Bobby Corrigan, urban rodentologist and formerly with the NYC Department of Health criticizes the city's efforts for the first time on the record.

https://thomasseiyawalsh.wixsite.com/ratstone


Geology Of The Northern Alto Relex Area, Big Bend National Park, Brewster County, Texas, Robert Schoen Dec 2017

Geology Of The Northern Alto Relex Area, Big Bend National Park, Brewster County, Texas, Robert Schoen

Electronic Theses and Dissertations

Detailed, 1:12,000-scale geologic field mapping was conducted around Alto Relex in the northern Sierra Del Carmen Mountains in Big Bend National Park. Alto Relex is a prominent, near vertical, ~1000 foot-high fault-line scarp. Cretaceous rocks in the area were folded and faulted by Laramide compression, intruded by Tertiary sills and overprinted by high-angle normal faults from Basin and Range extension. During the Laramide Orogeny and Basin and Range extension, the underlying basement shear zone called, the Texas Lineament, was reactivated creating a transpressional and transtensional regimes. The general geology of this area was outlined by Moustafa (1988) working primarily from …


Structural Analysis Of The Northwest Wind Mountain Quadrangle, New Mexico: Proterozoic Shearing To Cenozoic Brittle Faulting In The Burro Mountains, Jensen Kohl Angelloz Dec 2017

Structural Analysis Of The Northwest Wind Mountain Quadrangle, New Mexico: Proterozoic Shearing To Cenozoic Brittle Faulting In The Burro Mountains, Jensen Kohl Angelloz

Electronic Theses and Dissertations

Preliminary investigation of the Bullard Peak metamorphic series (BPMS) in the northwestern Wind Mountain quadrangle within the Burro Mountains of southwestern New Mexico suggests a possible previously unidentified shear zone, prompting detailed (1:12,000) geologic mapping and collection of structural data. The study area has a complex tectonic history, including 1) ~1.65 Ga metamorphism during accretion of the Mazatzal terrane to Laurentia’s southern margin; 2) ~1.4 Ga intrusion of Granite and Rhyolite Province granitoids; 3) significant uplift during the formation of the Ancestral Rockies (~300 Ma) and the Rocky Mountains (~70-50 Ma); and 4) inversion tectonics with reactivation of compressional faults …


Outer Space: A Steam Voyage, Jancy Mcphee Dec 2017

Outer Space: A Steam Voyage, Jancy Mcphee

The STEAM Journal

SciArt Exchange offers multi-disciplinary art contests, artwork events, consulting, training and community resources to support science and technology education, collaboration, and innovation. Using a science-integrated- with-art approach, SciArt Exchange supports, prepares, and convenes people of all ages, backgrounds and affiliations to discuss and potentially solve space, science, and technology challenges. This field note shares the Humans in Space Art Program and the Project Mars Competition.


Cataloging Wonder: The Art And Science Of The Collection, Christine Metzger Dec 2017

Cataloging Wonder: The Art And Science Of The Collection, Christine Metzger

The STEAM Journal

The Exploring Science in the Studio National Science Foundation grant funded three initiatives at California College of the Arts, a private four-year art and design college in the San Francisco Bay Area. The grant sponsored annual Science-in-the-Studio which embedded scientists into the art and design studio curriculum, the creation of Mobile Units for Scientific Exploration (MUSE) and a new collection of science materials, equipment, and natural specimens, and a national symposium on integrating science into the art and design studio curriculum. Approximately 30 SitS classes have been offered since 2010, and the Exploring Science in the Studio symposium was convened …


Getting Girls In Stem & The Dangers Of Forgetting That Science Is Art - Someone Made It Up, Heidi Therese Dangelmaier, Camilla Hermann Dec 2017

Getting Girls In Stem & The Dangers Of Forgetting That Science Is Art - Someone Made It Up, Heidi Therese Dangelmaier, Camilla Hermann

The STEAM Journal

Encouraging girls to participate in STEM is a hot topic that has captured the concern of the world’s academic, business and scientific communities. The intention is noble, however the strategies being deployed are reinforcing the very bias society seeks to eliminate. If we wish to advance our evolutionary journey as a species, a shift from “feeling sorry for disadvantaged girls” to “fearing STEM without girls’ reformation” is imperative. This piece discusses the rise to an initiative to redesign culture: Girlapproved.


Discovering And Demonstrating Patterns, Maria Klawe Dec 2017

Discovering And Demonstrating Patterns, Maria Klawe

The STEAM Journal

Harvey Mudd College's President Maria Klawe shares her personal journey in combining a love of mathematics and art.


Feasible Computation In Symbolic And Numeric Integration, Robert H.C. Moir Dec 2017

Feasible Computation In Symbolic And Numeric Integration, Robert H.C. Moir

Electronic Thesis and Dissertation Repository

Two central concerns in scientific computing are the reliability and efficiency of algorithms. We introduce the term feasible computation to describe algorithms that are reliable and efficient given the contextual constraints imposed in practice. The main focus of this dissertation then, is to bring greater clarity to the forms of error introduced in computation and modeling, and in the limited context of symbolic and numeric integration, to contribute to integration algorithms that better account for error while providing results efficiently.

Chapter 2 considers the problem of spurious discontinuities in the symbolic integration problem, proposing a new method to restore continuity …


Adsorbed Gas Behaviour And Guest-Host Interactions In Ultramicroporous Metal-Organic Frameworks, Bligh Desveaux Dec 2017

Adsorbed Gas Behaviour And Guest-Host Interactions In Ultramicroporous Metal-Organic Frameworks, Bligh Desveaux

Electronic Thesis and Dissertation Repository

Metal-organic frameworks (MOFs) are a class of porous materials that have attracted much attention due to their large surface areas, high tunability and their high selectivity for gas adsorption applications. In this work, solid-state nuclear magnetic resonance (SSNMR) experiments and single crystal X-ray diffraction (SCXRD) experiments are used to investigate carbon dioxide adsorption within the ultramicroporous MOFs SIFSIX-3-Zn (Chapter 2) and ZnAtzOx. (Chapter 3). Analysis finds that the CO2 SIFSIX-3-Zn undergoes wobbling motions with a low temperature dependence, and in ZnAtzOx undergoes wobbling and hopping motions with a low temperature dependence. SCXRD is used to precisely determine the CO …


Rethinking Holocene Ecological Relationships Among Caribou, Muskoxen, And Human Hunters On Banks Island, Nwt, Canada: A Stable Isotope Approach, Jordon S. Munizzi Dec 2017

Rethinking Holocene Ecological Relationships Among Caribou, Muskoxen, And Human Hunters On Banks Island, Nwt, Canada: A Stable Isotope Approach, Jordon S. Munizzi

Electronic Thesis and Dissertation Repository

This dissertation explores the ecology of caribou (Rangifer tarandus spp.) and muskoxen (Ovibos moschatus), and its relevance to human hunters on Banks Island, NWT, Canada, over the last 4000 years, primarily through the isotopic analysis of modern and archaeological faunal remains.

First, we establish baseline carbon and nitrogen isotope relationships between modern vegetation and caribou and muskox bone collagen using Bayesian mixing models. The models indicate that dwarf shrub (Salix arctica) does not contribute significantly to bone collagen isotopic compositions in either species, while sedges and yellow lichen (Cetraria tilesii) do. These findings …


Fluoroethoxy-1,4-Diphenethylpiperidine And Piperazine Derivatives: Potent And Selective Inhibitors Of [3H]Dopamine Uptake At The Vesicular Monoamine Transporter-2, Emily R. Hankosky, Shyam R. Joolakanti, Justin R. Nickell, Venumadhav Janganati, Linda P. Dwoskin, Peter A. Crooks Dec 2017

Fluoroethoxy-1,4-Diphenethylpiperidine And Piperazine Derivatives: Potent And Selective Inhibitors Of [3H]Dopamine Uptake At The Vesicular Monoamine Transporter-2, Emily R. Hankosky, Shyam R. Joolakanti, Justin R. Nickell, Venumadhav Janganati, Linda P. Dwoskin, Peter A. Crooks

Pharmaceutical Sciences Faculty Publications

A small library of fluoroethoxy-1,4-diphenethyl piperidine and fluoroethoxy-1,4-diphenethyl piperazine derivatives were designed, synthesized and evaluated for their ability to inhibit [3H]dopamine (DA) uptake at the vesicular monoamine transporter-2 (VMAT2) and dopamine transporter (DAT), [3H]serotonin (5-HT) uptake at the serotonin transporter (SERT), and [3H]dofetilide binding at the human-ether-a-go-go-related gene (hERG) channel. The majority of the compounds exhibited potent inhibition of [3H]DA uptake at VMAT2, with Ki values in the nanomolar range (Ki = 0.014–0.073 μM). Compound 15d exhibited the highest affinity (Ki = 0.014 μM) at VMAT2, and had 160-, 5-, …


First Low-Frequency Einstein@Home All-Sky Search For Continuous Gravitational Waves In Advanced Ligo Data, B. P. Abbott, R. Abbott, T. D. Abbott, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Afrough, B. Agarwal, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, B. Allen, G. Allen, A. Allocca, P. A. Altin, A. Amato, A. Ananyeva, S. B. Anderson, W. G. Anderson, S. Antier, S. Appert, K. Arai, M. C. Araya, Marc Favata, Shaon Ghosh Dec 2017

First Low-Frequency Einstein@Home All-Sky Search For Continuous Gravitational Waves In Advanced Ligo Data, B. P. Abbott, R. Abbott, T. D. Abbott, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Afrough, B. Agarwal, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, B. Allen, G. Allen, A. Allocca, P. A. Altin, A. Amato, A. Ananyeva, S. B. Anderson, W. G. Anderson, S. Antier, S. Appert, K. Arai, M. C. Araya, Marc Favata, Shaon Ghosh

Department of Physics and Astronomy Faculty Scholarship and Creative Works

We report results of a deep all-sky search for periodic gravitational waves from isolated neutron stars in data from the first Advanced LIGO observing run. This search investigates the low frequency range of Advanced LIGO data, between 20 and 100 Hz, much of which was not explored in initial LIGO. The search was made possible by the computing power provided by the volunteers of the Einstein@Home project. We find no significant signal candidate and set the most stringent upper limits to date on the amplitude of gravitational wave signals from the target population, corresponding to a sensitivity depth of 48.7 …


First Narrow-Band Search For Continuous Gravitational Waves From Known Pulsars In Advanced Detector Data, B. P. Abbott, R. Abbott, T. D. Abbott, F. Acernese, K. Ackley, C. Adams, T. Adams, Marc Favata, Shaon Ghosh, Rodica Martin Dec 2017

First Narrow-Band Search For Continuous Gravitational Waves From Known Pulsars In Advanced Detector Data, B. P. Abbott, R. Abbott, T. D. Abbott, F. Acernese, K. Ackley, C. Adams, T. Adams, Marc Favata, Shaon Ghosh, Rodica Martin

Department of Physics and Astronomy Faculty Scholarship and Creative Works

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signal-to-noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars …


Seasonal Resource Selection And Habitat Treatment Use By A Fringe Population Of Greater Sage-Grouse, Rhett Boswell Dec 2017

Seasonal Resource Selection And Habitat Treatment Use By A Fringe Population Of Greater Sage-Grouse, Rhett Boswell

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Movement and habitat selection by Greater Sage-grouse (Centrocercus uropasianus) is of great interest to wildlife managers tasked with applying conservation measures for this iconic western species. Current technology has created small and lightweight GPS (Global Positioning Systems) transmitters that can be attached to sage-grouse. Using GIS software and statistical programs such as Program R, land managers can analyze GPS location data to assess how sage-grouse are geospatially interacting with their habitats. Within the Panguitch Sage-Grouse Management Area (SGMA) thousands of acres of land have been restored or manipulated to enhance sage-grouse habitat; this usually involves removal of pinyon pine …


Probing Consciousness, Samia Bouzid Dec 2017

Probing Consciousness, Samia Bouzid

Capstones

For centuries, the study of consciousness remained the purview of philosophers, spiritualists and religious leaders. But in the 1980s, the co-discoverer of the double-helix, James Crick, initiated a quest for a scientific explanation for consciousness — in a secret club. In the decades that followed, consciousness gained ground as a respectable area of scientific study, in fields such as neuroscience, artificial intelligence and physics. Yet, the more scientists learn about consciousness, the more it calls into question our fundamental assumptions about the way the world works. https://samiabouzid.atavist.com/probing-consciousness


Hazmat Storage Near Nyc Waterways Endangers Communities, Brett E. Dahlberg, Nicole Acevedo Dec 2017

Hazmat Storage Near Nyc Waterways Endangers Communities, Brett E. Dahlberg, Nicole Acevedo

Capstones

New York City has 520 miles of shoreline--that’s more than Miami and Los Angeles combined. These waterfronts are home to some of the city’s most polluted sites because major part of it is zoned for industrial use. Dozens of industrial plants in this area store toxic chemicals in flood zones: substances that are hazardous to our health, like Benzene, which is used in rocket fuel, toluene, a paint thinner, and lead a neurotoxin. In a flood, these chemicals can easily get caught up in moving waters and pollute entire neighborhoods.

That’s exactly what happened when Hurricane Sandy hit in 2012. …


Breadcrumbs: Privacy As A Privilege, Prachi Bhardwaj Dec 2017

Breadcrumbs: Privacy As A Privilege, Prachi Bhardwaj

Capstones

Breadcrumbs: Privacy as a Privilege Abstract

By: Prachi Bhardwaj

In 2017, the world saw more data breaches than in any year prior. The count was more than the all-time high record in 2016, which was 40 percent more than the year before that.

That’s because consumer data is incredibly valuable today. In the last three decades, data storage has gone from being stored physically to being stored almost entirely digitally, which means consumer data is more accessible and applicable to business strategies. As a result, companies are gathering data in ways previously unknown to the average consumer, and hackers are …


Exploring The Differences Between Human And Machine Translation, Connor Freitas, Yudong Liu Dec 2017

Exploring The Differences Between Human And Machine Translation, Connor Freitas, Yudong Liu

WWU Honors College Senior Projects

Chinese second language learners of English often use Machine Translators (MT) to translate personal and professional messages from their first language to English. MT’s are not perfect and have historically create messages that lack the cohesiveness and authenticity of natively written English. This paper describes our attempts to quantify the differences between human translation and machine translation in a specific scope with that hope that both MTs and post editing systems can be benefited through awareness of common error and differences between human and machine translations. In order to achieve this we implemented existing algorithms designed to identify common errors …


Tensorviz: Visualizing The Training Of Convolutional Neural Network Using Paraview, Xinyu Chen, Qiang Guan, Xin Liang, Li-Ta Lo, Simon Su, Trilce Estrada, James Ahrens Dec 2017

Tensorviz: Visualizing The Training Of Convolutional Neural Network Using Paraview, Xinyu Chen, Qiang Guan, Xin Liang, Li-Ta Lo, Simon Su, Trilce Estrada, James Ahrens

Computer Science Faculty Research & Creative Works

Deep Convolutional Networks have been very successful in visual recognition tasks recently. Previous works visualize learned features at different layers o help people to understand how CNNs learn visual recognition tasks. However they do not help to accelerate the training process. We use Paraview to provides both qualitative and quantitative visualization that help understand the learning procedure, tune the learning parameters and direct merging and pruning of neural networks.


Tensorviz: Visualizing The Training Of Convolutional Neural Network Using Paraview (Poster), Xinyu Chen, Qiang Guan, Xin Liang, Li-Ta Lo, Simon Su, Trilce Estrada, James Ahrens Dec 2017

Tensorviz: Visualizing The Training Of Convolutional Neural Network Using Paraview (Poster), Xinyu Chen, Qiang Guan, Xin Liang, Li-Ta Lo, Simon Su, Trilce Estrada, James Ahrens

Computer Science Faculty Research & Creative Works

Deep Convolutional Networks have been very successful in visual recognition tasks recently. Lots of previous works aimed to help people to get senses of why those biology-inspired networks achieved such good performances. Deconvnet[1], Guided propagation[2] and a comprehensive visualization tool box[3] can help people to see features learned at different layers of the networks. These works in some extent provided understanding and support for the biology origin of how convolutional networks emulate visual recognition tasks. However, due to the complexity of searching in very high dimensional parameter space, the whole training remains in black-boxes. Normally a large network needs weeks …


Synthesis, Characterization, And Spectroscopy Of Donor-Acceptor Charge Transfer Complexes, Dominic K. Kersi Dec 2017

Synthesis, Characterization, And Spectroscopy Of Donor-Acceptor Charge Transfer Complexes, Dominic K. Kersi

Chemistry and Chemical Biology ETDs

A series of square-planar metal (diimine)(dichalcogenolene) chromophoric complexes have been synthesized, characterized and studied spectroscopically. Studies conducted on diimineplatinum(II) dichalcogenolene complexes (LPtL’) using time resolved spectroscopic techniques such as transient absorption and emission, reveal a charge-separated excited state of the type dichalcogenolene → diimine charge-transfer (LL’CT) [(dichalcogenolene•+)Pt(diimine-) with an open shell donor-acceptor biradical character. Long-live excited state lifetimes were observed for these complexes upon visible photoexcitation of the LL’CT or MMLL’CT band. A direct linear relationship is observed to exist between photoluminescence rates, calculated SOC matrix elements, and 13C-NMR chemical shifts.

A series of …


Accurate Determination And Application Of Local Strain For Studying Tissues With Gradients In Mechanical Properties, John Boyle Dec 2017

Accurate Determination And Application Of Local Strain For Studying Tissues With Gradients In Mechanical Properties, John Boyle

McKelvey School of Engineering Theses & Dissertations

Determination of the mechanical behavior of materials requires an understanding of deformation during loading. While this is traditionally accomplished in engineering by examining a force displacement curve for a whole sample, these techniques implicitly ignore local geometric complexities and local material inhomogeneities commonly found in biologic tissues. Techniques such as normalized cross correlation have been classically applied to address this issue and resolve deformation at the local level; however, these techniques have proven unreliable when deformations become large, if the sample undergoes a rotation, and/or if strain fields become incompatible (e.g. at or near failure).

Presented here is a toolbox …


Evaluating Potential For Water Quality Decline In Maine Lakes, Kaci N. Fitzgibbon Dec 2017

Evaluating Potential For Water Quality Decline In Maine Lakes, Kaci N. Fitzgibbon

Electronic Theses and Dissertations

Understanding lake vulnerability with respect to eutrophication and loss of water quality is important for sustainability of aquatic ecosystems. This project aims at identifying and quantifying the effects of relevant physiochemical, climate, and watershed characteristics on lake vulnerability in order to develop management decision tools for the Maine Department of Environmental Protection (MEDEP). In a changing chemical and physical environment, using independent variables from each of these categories and then relating them to the summer lake epilimnetic phosphorus (P) concentrations allows for development of models to inform stakeholders of lake vulnerability to eutrophication problems.

We studied 24 lakes covering a …


Relativistic Three-Dimensional Lippman-Schwinger Cross Sections For Space Radiation Applications, Charles M. Werneth, Xiaojing Xu, Ryan B. Norman, Khin M. Maung Dec 2017

Relativistic Three-Dimensional Lippman-Schwinger Cross Sections For Space Radiation Applications, Charles M. Werneth, Xiaojing Xu, Ryan B. Norman, Khin M. Maung

Faculty Publications

Radiation transport codes require accurate nuclear cross sections to compute particle fluences inside shielding materials. The Tripathi semi-empirical reaction cross section, which includes over 60 parameters tuned to nucleon-nucleus (NA) and nucleus-nucleus (AA) data, has been used in many of the world’s best-known transport codes. Although this parameterization fits well to reaction cross section data, the predictive capability of any parameterization is questionable when it is used beyond the range of the data to which it was tuned. Using uncertainty analysis, it is shown that a relativistic three-dimensional Lippmann-Schwinger (LS3D) equation model based on Multiple Scattering Theory (MST) that uses …


Reduced Light Availability Diminishes Mycorrhizal Growth Response Of Invasive Forb, Regina O'Kelley Dec 2017

Reduced Light Availability Diminishes Mycorrhizal Growth Response Of Invasive Forb, Regina O'Kelley

WWU Honors College Senior Projects

Arbuscular mycorrhizal fungi (AMF) form mycorrhizae, a common, well-studied symbiotic relationship. Controls on the magnitude and direction of plant mycorrhizal growth response (MGR) remain obscured. Specifically, the influence of light availability in the MGR of an invasive forb, spotted knapweed Centaurea stoebe, has not been studied. Greenhouse studies exploring the growth response of knapweed to arbuscular mycorrhizae (AM) often fail to report light intensity levels, which could impact the quality of their data. I conducted a greenhouse experiment studying the MGR in spotted knapweed under shaded and unshaded conditions, designed to approximate light availability in ambient greenhouse and full-sun …


Effect Of An 860-M Thick, Cold, Freshwater Aquifer On Geothermal Potential Along The Axis Of The Eastern Snake River Plain, Idaho, Thomas E. Lachmar, Thomas G. Freeman, Christopher J. Sant, Jeffrey R. Walker, Joseph F. Batir, John W. Shervais, James P. Evans, Dennis L. Nielson, David D. Blackwell Dec 2017

Effect Of An 860-M Thick, Cold, Freshwater Aquifer On Geothermal Potential Along The Axis Of The Eastern Snake River Plain, Idaho, Thomas E. Lachmar, Thomas G. Freeman, Christopher J. Sant, Jeffrey R. Walker, Joseph F. Batir, John W. Shervais, James P. Evans, Dennis L. Nielson, David D. Blackwell

Geosciences Faculty Publications

A 1912-m exploration corehole was drilled along the axis of the eastern Snake River Plain, Idaho. Two temperature logs run on the corehole display an obvious inflection point at about 960 m. Such behavior is indicative of downward fluid flow in the wellbore. The geothermal gradient above 935 m is 4.5 °C/km, while the gradient is 72–75 °C/km from 980 to 1440 m. Projecting the higher gradients upward to where they intersect the lower gradient on the temperature logs places the bottom of the cold, freshwater Snake River Plain aquifer, which suppresses the geothermal gradient at this location, at least …


System Characterizations And Optimized Reconstruction Methods For Novel X-Ray Imaging, Huifeng Guan Dec 2017

System Characterizations And Optimized Reconstruction Methods For Novel X-Ray Imaging, Huifeng Guan

McKelvey School of Engineering Theses & Dissertations

In the past decade there have been many new emerging X-ray based imaging technologies developed for different diagnostic purposes or imaging tasks. However, there exist one or more specific problems that prevent them from being effectively or efficiently employed. In this dissertation, four different novel X-ray based imaging technologies are discussed, including propagation-based phase-contrast (PB-XPC) tomosynthesis, differential X-ray phase-contrast tomography (D-XPCT), projection-based dual-energy computed radiography (DECR), and tetrahedron beam computed tomography (TBCT). System characteristics are analyzed or optimized reconstruction methods are proposed for these imaging modalities. In the first part, we investigated the unique properties of propagation-based phase-contrast imaging technique …


Repairing Gaps In Kinari-2 For Large Scale Protein And Flexibility Analysis Applications, Magdalena Metlicka, Mojtaba Nouri Bygi, Ileana Streinu Dec 2017

Repairing Gaps In Kinari-2 For Large Scale Protein And Flexibility Analysis Applications, Magdalena Metlicka, Mojtaba Nouri Bygi, Ileana Streinu

Computer Science: Faculty Publications

Pebble game rigidity analysis is a combinatorial method, implemented in our free web server KinariWeb, for extracting protein rigidity and flexibility information without performing costly molecular dynamics simulations. Due to the idiosynchrasies of the data in the Protein Data Bank (PDB), Kinari succeeds only on a fraction of the available files. Motivated by large scale applications, aiming at processing almost all the PDB files, we have recently developed a faster and more robust version, the phased pebble game algorithm. It is specifically designed to take advantage of the sequential structure of biopolymers. However, the structural data available in the Protein …


Two-Component Hydrogel As Biomimetic Vitreous Substitutes, Sruthi Santhanam Dec 2017

Two-Component Hydrogel As Biomimetic Vitreous Substitutes, Sruthi Santhanam

McKelvey School of Engineering Theses & Dissertations

The vitreous humor of the eye is a biological hydrogel principally composed of fibrillary collagen interspersed with semi-flexible polyelectrolyte, hyaluronic acid (HA). Certain pathological conditions necessitate its removal and replacement. Current vitreous substitutes, such as silicone oils and perfluorocarbons, are hydrophobic, do not resemble the properties of the vitreous, and have known complications. An ideal vitreous substitute should have properties of the natural vitreous, perform its functions, and be biocompatible in the eye. Inspired by the structure and composition of the natural vitreous, we used bio-mimicry to develop an injectable two-component hydrogel. The hydrogel is composed of a fibrillary gellan, …


The Future Of Nuclear Security: A Medical Physicist’S Perspective, Katharine E. Thomson Dec 2017

The Future Of Nuclear Security: A Medical Physicist’S Perspective, Katharine E. Thomson

International Journal of Nuclear Security

Planning for the future of nuclear security is a vital and complex task, requiring cooperation and contribution from many disciplines and industries. This diversity of expertise should include the medical sector, which faces many of the same challenges as the nuclear industry: controlling access to dangerous material, creating a strong security culture, cooperating with the wider world and engaging the public.

Medical physicists, of which the author is one, oversee all aspects of small-scale radiation use. This paper discusses three key areas increasingly important to both medical and nuclear uses of radioactive materials: public engagement, prevention of nuclear and radiological …