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Articles 1561 - 1590 of 15927
Full-Text Articles in Physical Sciences and Mathematics
Food Habits Of Coyotes (Canis Latrans) In The Valles Caldera National Preserve, New Mexico, Suzanne J. Gifford, Eric M. Gese, Robert R. Parmenter
Food Habits Of Coyotes (Canis Latrans) In The Valles Caldera National Preserve, New Mexico, Suzanne J. Gifford, Eric M. Gese, Robert R. Parmenter
United States Department of Agriculture Wildlife Services: Staff Publications
Wildlife managers needed to understand coyote (Canis latrans) ecology in order to develop management plans on the nascent Valles Caldera National Preserve in northern New Mexico. Managers concerned about low elk (Cervus elaphus) recruitment had observed an increase in sightings of coyotes and observations of coyote predation on elk calves. Our objective was to identify and quantify coyote diet, and assess the temporal variation in coyote diet on the Valles Caldera National Preserve, particularly as related to elk calf consumption. We examined coyote food habits using 1,385 scats analyzed monthly from May 2005 to November 2008. The most frequent taxa …
Advances In Remote Sensing To Understand Extreme Hydrological Events, Dongkyun Kim, Minha Choi, Jongho Kim, Ungtae Kim
Advances In Remote Sensing To Understand Extreme Hydrological Events, Dongkyun Kim, Minha Choi, Jongho Kim, Ungtae Kim
Civil and Environmental Engineering Faculty Publications
No abstract provided.
Isotope Summary Data, Andrew Kulmatiski
Isotope Summary Data, Andrew Kulmatiski
Browse all Datasets
Data includes deuterium tracer uptake data from plant species at the US Sheep Experiment Station.
The Adaptations Of The Sulfur-Oxidizing, Gammaproteobacterium "Candidatus Endoriftia Persephone", Endosymbiont Of The Giant Tubeworm Riftia Pachyptila, To Hydrothermal Vent Habitat Heterogeneity, Juliana M. Leonard
USF Tampa Graduate Theses and Dissertations
The siboglinid tubeworm Riftia pachyptila is a dominant member of the deep-sea megafauna where seawater and hydrothermal vent (HTV) effluent interface and mix. It is one of the fastest growing invertebrates on land or in the sea. It does not have a digestive tract (e.g. mouth, gut, or anus), and is completely dependent on its sulfur-oxidizing endosymbiont, the Gammaproteobacterium “Candidatus Endoriftia persephone” for its nutritional requirements. This association was the first and is the most well studied among chemolithoautotrophic symbioses. “Ca. E. persephone” is a chemolithoautotrophic bacterium that oxidizes sulfide as an electron donor for energy, reduces oxygen as a …
Design, Synthesis, And Self-Assembly Of Supramolecular Fractals Based On Terpyridine With Different Transition Metal Ions, Lei Wang
USF Tampa Graduate Theses and Dissertations
Fractals have existed in a variety of natural forms, and the concept of "fractal geometry" has been developed in many areas by humankind, including art, economics, mathematics, physics, chemistry, material science, and etc. In the field of chemistry, researchers have endeavored great efforts to express the concept using molecules either by theoretical prediction or using synthetic methods in the past few decades, and one successful example is the “Sierpiński triangle”. Challenge still remains to achieve other fractal geometries as well as high generation of fractals with precisely controlled shape and size. Coordination-driven self-assembly has witnessed a wide array of well-defined …
Microplastic Concentrations In Two Oregon Bivalve Species: Spatial, Temporal, And Species Variability, Britta Baechler, Elise F. Granek, Matthew V. Hunter, Kathleen E. Conn
Microplastic Concentrations In Two Oregon Bivalve Species: Spatial, Temporal, And Species Variability, Britta Baechler, Elise F. Granek, Matthew V. Hunter, Kathleen E. Conn
Environmental Science and Management Faculty Publications and Presentations
Microplastics are an ecological stressor with implications for ecosystem and human health when present in seafood. We quantified microplastic types, concentrations, anatomical burdens, geographic distribution, and temporal differences in Pacific oysters (Crassostrea gigas) and Pacific razor clams (Siliqua patula) from 15 Oregon coast, U.S.A. sites. Microplastics were present in organisms from all sites. On average, whole oysters and razor clams contained 10.95 ± 0.77 and 8.84 ± 0.45 microplastic pieces per individual, or 0.35 ± 0.04 pieces g−1 tissue and 0.16 ± 0.02 pieces g−1 tissue, respectively. Contamination was quantified but not subtracted. Over …
Seismic Evidence For Significant Melt Beneath The Long Valley Caldera, California, Usa, Ashton F. Flinders, David R. Shelly, Philip B. Dawson, David P. Hill, Barbara Tripoli, Yang Shen
Seismic Evidence For Significant Melt Beneath The Long Valley Caldera, California, Usa, Ashton F. Flinders, David R. Shelly, Philip B. Dawson, David P. Hill, Barbara Tripoli, Yang Shen
United States Geological Survey: Staff Publications
A little more than 760 ka ago, a supervolcano on the eastern edge of California (United States) underwent one of North America’s largest Quaternary explosive eruptions. Over this ~6-day-long eruption, pyroclastic flows blanketed the surrounding ~50 km with more than 1400 km3 of the now-iconic Bishop Tuff, with ashfall reaching as far east as Nebraska. Collapse of the volcano’s magma reservoir created the restless Long Valley Caldera. Although no rhyolitic eruptions have occurred in 100 k.y., beginning in 1978, ongoing uplift suggests new magma may have intruded into the reservoir. Alternatively, the reservoir could be approaching final crystallization, with present-day …
How Airport Construction Will Evolve With The Increased Effects Of Climate Change, Xavier M. Ashley
How Airport Construction Will Evolve With The Increased Effects Of Climate Change, Xavier M. Ashley
Beyond: Undergraduate Research Journal
This report addressed the effects rising global temperatures resulting from climate change have had on flight operations in their entirety. The research objective was to discover what methods could enhance climate adaptation in airport construction, as higher mean-surface temperatures have an increasingly negative effect on aircraft performance. The findings would primarily be of interest to the Federal Aviation Administration (FAA) Primary Office presiding over the planning and development of airports. Overall, the report provided a comprehensive analysis of global warming’s effects on aviation, including the implications of degraded aircraft performance and sea-level rise for coastal airports. Additionally, it examined comparative …
Honors Interdisciplinary Seminar Syllabus (Letters & Natural Sciences/Math), Terri J. Nelson, Davida Fischman
Honors Interdisciplinary Seminar Syllabus (Letters & Natural Sciences/Math), Terri J. Nelson, Davida Fischman
Q2S Enhancing Pedagogy
This syllabus outline is for an interdisciplinary, upper-division Honors course to be taught in Spring 2021. The team-taught course will include two Reacting to the Past games: (1) Building the Italian Renaissance: Brunelleschi's Dome & the Florence Cathedral and (2) The Trial of Galileo: Aristotelianism, the "New Cosmology," and the Catholic Church, 1616-1633. The course will culminate with the design, development and enactment of a student-created Reacting game. An detailed list of student learning out is included.
Spatially Resolved Stellar Kinematics Of The Ultra-Diffuse Galaxy Dragonfly 44. Ii. Constraints On Fuzzy Dark Matter, Asher Wasserman, Pieter Van Dokkum, Aaron Romanowsky, Jean Brodie, Shany Danieli, Duncan Forbes, Roberto Abraham, Christopher Martin, Matt Matuszewski, Alexa Villaume, John Tamanas, Stefano Profumo
Spatially Resolved Stellar Kinematics Of The Ultra-Diffuse Galaxy Dragonfly 44. Ii. Constraints On Fuzzy Dark Matter, Asher Wasserman, Pieter Van Dokkum, Aaron Romanowsky, Jean Brodie, Shany Danieli, Duncan Forbes, Roberto Abraham, Christopher Martin, Matt Matuszewski, Alexa Villaume, John Tamanas, Stefano Profumo
Faculty Publications
Given the absence of directly detected dark matter (DM) as weakly interacting massive particles, there is strong interest in the possibility that DM is an ultralight scalar field, here denoted as "fuzzy" DM. Ultra-diffuse galaxies, with the sizes of giant galaxies and the luminosities of dwarf galaxies, have a wide range of DM halo masses, thus providing new opportunities for exploring the connections between galaxies and their DM halos. Following up on new integral field unit spectroscopic observations and dynamics modeling of the DM-dominated ultra-diffuse galaxy Dragonfly 44 in the outskirts of the Coma Cluster, we present models of fuzzy …
Introduction Of A Hybrid Monitor For Cyber-Physical Systems, J. Ceasar Aguma, Bruce M. Mcmillin, Amelia Regan
Introduction Of A Hybrid Monitor For Cyber-Physical Systems, J. Ceasar Aguma, Bruce M. Mcmillin, Amelia Regan
Computer Science Faculty Research & Creative Works
Computing systems and mobile technologies have changed dramatically since the introduction of firewall technology in 1988. The internet has grown from a simple network of networks to a cyber and physical entity that encompasses the entire planet. Cyber-physical systems(CPS) now control most of the day to day operations of human civilization from autonomous cars to nuclear energy plants. While phenomenal, this growth has created new security threats. These are threats that cannot be blocked by a firewall for they are not only cyber but cyber-physical. In light of these cyber-physical threats, this paper proposes a security measure that promises to …
Aerial And Ground-Based Optical Gas Imaging Survey Of Uinta Basin Oil And Gas Wells, Seth N. Lyman, Trang Tran, Marc L. Mansfield, Arvind P. Ravikumar
Aerial And Ground-Based Optical Gas Imaging Survey Of Uinta Basin Oil And Gas Wells, Seth N. Lyman, Trang Tran, Marc L. Mansfield, Arvind P. Ravikumar
Bingham Research Center
We deployed a helicopter with an infrared optical gas imaging camera to detect hydrocarbon emissions from 3,428 oil and gas facilities (including 3,225 producing oil and gas well pads) in Utah’s Uinta Basin during winter and spring 2018. We also surveyed 419 of the same well pads from the ground. Winter conditions led to poor contrast between emission plumes and the ground, leading to a detection limit for the aerial survey that was between two and six times worse than a previous summertime survey. Because the ground survey was able to use the camera’s high-sensitivity mode, the rate of detected …
Structures And Energetics Of Clusters Surrounding Diatomic Anions Stabilized By Hydrogen, Halogen, And Other Noncovalent Bonds, Steve Scheiner, Mariusz Michalczyk, Rafal Wysokiński, Wiktor Zierkiewicz
Structures And Energetics Of Clusters Surrounding Diatomic Anions Stabilized By Hydrogen, Halogen, And Other Noncovalent Bonds, Steve Scheiner, Mariusz Michalczyk, Rafal Wysokiński, Wiktor Zierkiewicz
Chemistry and Biochemistry Faculty Publications
Diatomic anions CN-, NO-, and OH- are surrounded by 2, 3, and 4 ligand molecules drawn from the HF, HCl, XF, YF2, ZF3, TF4, and TrF3 set wherein X= Cl,Br, Y=S,Se, Z=P,As, T=Si,Ge, and Tr=Al,Ga. In the case of two ligands, both interact with the N of NO- and the O of OH-, but one approaches either end of CN-. Unlike the H and halogen bonding units, as the number of ligands increases there is a tendency for chalcogen, pnicogen, tetrel, and triel-bonding ligands to form a cage around the central anion, with strong inter-ligand noncovalent bonds. There are a …
Aluminum Secondary Electron Yield, Jr Dennison, Phillip Lundgreen
Aluminum Secondary Electron Yield, Jr Dennison, Phillip Lundgreen
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Accurate modeling of spacecraft charging is essential to mitigate well-known and all-too-common deleterious and costly effects on spacecraft resulting from charging induced by interactions with the space plasma environment. This paper addresses how limited availability of electron emission and transport properties of spacecraft materials—in particular secondary electron yields—and the wide range measured for such properties pose a critical issue for modeling spacecraft charging. It describes a materials charging database being developed, which when used in concert with the strategies outlined herein for best practices for establishing optimized materials properties for spacecraft charging models and specific mission requirements and how these …
Millimeter-Wavelength Characterization Of The Co Emission Of Comets 174p/Echeclus, 29p/Schwassmann-Wachmann, And C/2016 R2 (Panstarrs), Kacper Wierzchos
Millimeter-Wavelength Characterization Of The Co Emission Of Comets 174p/Echeclus, 29p/Schwassmann-Wachmann, And C/2016 R2 (Panstarrs), Kacper Wierzchos
USF Tampa Graduate Theses and Dissertations
Comets are fascinating minor solar system bodies. They contain some of the most pristine and unprocessed material found in the solar system. As a comet approaches the Sun it displays the characteristic cometary coma and tail. This is due to the release of volatile species through a variety of processes. In the present work I studied the carbon monoxide emission of three very unique comets; 174P/Echeclus, 29P/Schwassmann-Wachmann and C/2016 R2 (PanSTARRS) with different radio telescopes at millimeter wavelengths. After molecular hydrogen, carbon monoxide is the second most abundant molecule in the universe, and is also the most volatile of the …
Multi-Hop Knowledge Base Question Answering With An Iterative Sequence Matching Model, Yunshi Lan, Shuohang Wang, Jing Jiang
Multi-Hop Knowledge Base Question Answering With An Iterative Sequence Matching Model, Yunshi Lan, Shuohang Wang, Jing Jiang
Research Collection School Of Computing and Information Systems
Knowledge Base Question Answering (KBQA) has attracted much attention and recently there has been more interest in multi-hop KBQA. In this paper, we propose a novel iterative sequence matching model to address several limitations of previous methods for multi-hop KBQA. Our method iteratively grows the candidate relation paths that may lead to answer entities. The method prunes away less relevant branches and incrementally assigns matching scores to the paths. Empirical results demonstrate that our method can significantly outperform existing methods on three different benchmark datasets.
Magnetic Field Effect In The Fine-Structure Constant And Electron Dynamical Mass, Efrain J. Ferrer, A. Sanchez
Magnetic Field Effect In The Fine-Structure Constant And Electron Dynamical Mass, Efrain J. Ferrer, A. Sanchez
Physics and Astronomy Faculty Publications and Presentations
We investigate the effect of an applied constant and uniform magnetic field in the fine-structure constant of massive and massless QED. In massive QED, it is shown that a strong magnetic field removes the so called Landau pole and that the fine-structure constant becomes anisotropic having different values along and transverse to the field direction. Contrary to other results in the literature, we find that the anisotropic fine-structure constant always decreases with the field. We also study the effect of the running of the coupling constant with the magnetic field on the electron mass. We find that in both cases …
Land Surface Temperature Variability Across India: A Remote Sensing Satellite Perspective, Satya Prakash, Hamidreza Norouzi
Land Surface Temperature Variability Across India: A Remote Sensing Satellite Perspective, Satya Prakash, Hamidreza Norouzi
Publications and Research
Land surface temperature (LST) plays a key role in the surface energy budget computation and land surface process studies. The Moderate Resolution Imaging Spectroradiometer (MODIS) sensors onboard the Aqua and Terra satellites provide comprehensive global LST estimates at a fine spatial resolution. The MODIS products were recently upgraded to Collection 6, and shown to be more accurate than its predecessor Collection 5 products. In this study, LST and its variability have been examined across India from Collection 6 of the Aqua MODIS data at 0.05° spatial resolution for the period of 2003 to 2017. All-India mean LST characteristics show distinctive …
Source Function Of Na, Xuguang Cai
Source Function Of Na, Xuguang Cai
Xuguang Cai
Conditional Survival Analysis For Concrete Bridge Decks, Azam Nabizadeh, Habib Tabatabai, Mohammad A. Tabatabai
Conditional Survival Analysis For Concrete Bridge Decks, Azam Nabizadeh, Habib Tabatabai, Mohammad A. Tabatabai
Civil and Environmental Engineering Faculty Articles
Bridge decks are a significant factor in the deterioration of bridges, and substantially affect long-term bridge maintenance decisions. In this study, conditional survival (reliability) analysis techniques are applied to bridge decks to evaluate the age at the end of service life using the National Bridge Inventory records. As bridge decks age, the probability of survival and the expected service life would change. The additional knowledge gained from the fact that a bridge deck has already survived a specific number of years alters (increases) the original probability of survival at subsequent years based on the conditional probability theory. The conditional expected …
Retrospective Tillage Differentiation Using The Landsat-5 Tm Archive With Discriminant Analysis, Sonisa Sharma, Kundan Dhakal, Pradeep Wagle, Ayse Kilie
Retrospective Tillage Differentiation Using The Landsat-5 Tm Archive With Discriminant Analysis, Sonisa Sharma, Kundan Dhakal, Pradeep Wagle, Ayse Kilie
School of Natural Resources: Faculty Publications
Accurate and site-specific information on tillage practice is vital to understand the impacts of crop management on water quality, soil conservation, and soil carbon sequestration. Remote sensing is a cost-effective technique for surveillance and rapid assessment of tillage practice over large areas. A new empirical approach for accurately predicting tillage class using discriminant analysis (DA) on historical multitemporal Landsat-TM 5 imagery has been developed. Ground truth data were obtained from the USDA-NRCS at 48 locations (20 conventional till [CT] and 28 conservation tillage or no-till [NT]). Classification accuracies were obtained for the DA models using reflectance values of Landsat-5 TM …
Satellite-Based Decadal Change Assessments Of Pan-Arctic Environments, Liza K. Jenkins, Tom Barry, Karl R. Bosse, William S. Currie, Tom Christensen, Sara Longan, Robert A. Shuchman, Danielle Tanzer, Jason J. Taylor
Satellite-Based Decadal Change Assessments Of Pan-Arctic Environments, Liza K. Jenkins, Tom Barry, Karl R. Bosse, William S. Currie, Tom Christensen, Sara Longan, Robert A. Shuchman, Danielle Tanzer, Jason J. Taylor
United States National Park Service: Publications
Remote sensing can advance the work of the Circumpolar Biodiversity Monitoring Program through monitoring of satellite-derived terrestrial and marine physical and ecological variables. Standardized data facilitate an unbiased comparison across variables and environments. Using MODIS standard products of land surface temperature, percent snow-covered area, NDVI, EVI, phenology, burned area, marine chlorophyll, CDOM, sea surface temperature, and marine primary productivity, significant trends were observed in almost all variables between 2000 and 2017. Analysis of seasonal data revealed significant breakpoints in temporal trends. Within the terrestrial environment, data showed significant increasing trends in land surface temperature and NDVI. In the marine environment, …
Comparison Of Extraction Methods For Recovering Ancient Microbial Dna From Paleofeces, Richard Hagan, Courtney A. Hofman, Alexander Hübner, Karl Reinhard, Stephanie Schnorr, Cecil M. Lewis, Jr., Krithivasan Sankaranarayanan, Christina G. Warinner
Comparison Of Extraction Methods For Recovering Ancient Microbial Dna From Paleofeces, Richard Hagan, Courtney A. Hofman, Alexander Hübner, Karl Reinhard, Stephanie Schnorr, Cecil M. Lewis, Jr., Krithivasan Sankaranarayanan, Christina G. Warinner
School of Natural Resources: Faculty Publications
Objectives: Paleofeces are valuable to archeologists and evolutionary biologists for their potential to yield health, dietary, and host information. As a rich source of preserved biomolecules from host-associated microorganisms, they can also provide insights into the recent evolution and changing ecology of the gut microbiome. How- ever, there is currently no standard method for DNA extraction from paleofeces, which combine the dual challenges of complex biological composition and degraded DNA. Due to the scarcity and relatively poor preservation of paleofeces when compared with other archeological remains, it is important to use efficient methods that maximize ancient DNA (aDNA) recovery while …
Scompile: Critical Path Identification And Analysis For Smart Contracts, Jialiang Chang, Bo Gao, Hao Xiao, Jun Sun, Yan Cai, Zijiang Yang
Scompile: Critical Path Identification And Analysis For Smart Contracts, Jialiang Chang, Bo Gao, Hao Xiao, Jun Sun, Yan Cai, Zijiang Yang
Research Collection School Of Computing and Information Systems
Ethereum smart contracts are an innovation built on top of the blockchain technology, which provides a platform for automatically executing contracts in an anonymous, distributed, and trusted way. The problem is magnified by the fact that smart contracts, unlike ordinary programs, cannot be patched easily once deployed. It is important for smart contracts to be checked against potential vulnerabilities. In this work, we propose an alternative approach to automatically identify critical program paths (with multiple function calls including inter-contract function calls) in a smart contract, rank the paths according to their criticalness, discard them if they are infeasible or otherwise …
Perceptions Of The Effectiveness Of Food Policy Coalitions In Strengthening Community Food Security In The United States., Joseph G. England Iii
Perceptions Of The Effectiveness Of Food Policy Coalitions In Strengthening Community Food Security In The United States., Joseph G. England Iii
USF Tampa Graduate Theses and Dissertations
Food insecurity is experienced most acutely and addressed most innovatively at the community level to which the concept of community food security (CFS) finds purchase (Hamm and Bellows, 2003). In recognition of the many varying dynamics embedded in the CFS concept, Food Policy Coalitions have become an organizational model adapted by communities across the United States. While FPCs have grown in number considerably over the last decade, there remains a considerable lack of empirical research documenting evaluation and engagement methods, as well as strategies used to address community food security. This research, framed by the Community Coalition Action Theory, draws …
Alignment Of Theoretically Grounded Constructs For The Measurement Of Science And Chemistry Identity, Kathryn Nicole Hosbein, Jack Barbera
Alignment Of Theoretically Grounded Constructs For The Measurement Of Science And Chemistry Identity, Kathryn Nicole Hosbein, Jack Barbera
Chemistry Faculty Publications and Presentations
Identity has been theorized to aid in student persistence within STEM disciplines. In this study, science and chemistry identity were defined as being recognized as a science or chemistry person within the classroom. To generalize the effects that identity has on student persistence, a measurable construct must be defined, operationalized, and tested in multiple settings with different populations. This project addressed the first step in the process, defining the construct and grounding it in an established theoretical framework. This qualitative project utilized a previously described physics identity framework, with sub-constructs of performance/competence, recognition, and interest, as a starting point for …
The Firece Green Fire: Vol. 10 Issue 9, Wofford College Environmental Studies Program
The Firece Green Fire: Vol. 10 Issue 9, Wofford College Environmental Studies Program
The Fierce Green Fire
No abstract provided.
Ecohydrology Of Urban Trees Under Passive And Active Irrigation In A Semiarid City, Anthony M. Luketich, Shirley A. Papuga, Michael A. Crimmins
Ecohydrology Of Urban Trees Under Passive And Active Irrigation In A Semiarid City, Anthony M. Luketich, Shirley A. Papuga, Michael A. Crimmins
Environmental Science and Geology Faculty Research Publications
The infiltration of stormwater runoff for use by urban trees is a major co-benefit of green infrastructure for desert cities with limited water resources. However, the effects of this passive irrigation versus regular, controlled moisture inputs, or active irrigation, is largely unquantified. We monitored the ecohydrology of urban mesquite trees (Prosopis spp.) under these contrasting irrigation regimes in semiarid Tucson, AZ. Measurements included soil moisture, sap velocity, canopy greenness, and leaf-area index. We expected both irrigation types to provide additional deep (>20 cm) soil moisture compared to natural conditions, and that trees would depend on this deep …
Early Anthropoid Femora Reveal Divergent Adaptive Trajectories In Catarrhine Hind-Limb Evolution, Sergio Almecija, Melissa Tallman, Hesham M. Sallam, John G. Fleagle, Ashley S. Hammond, Erik R. Seiffert
Early Anthropoid Femora Reveal Divergent Adaptive Trajectories In Catarrhine Hind-Limb Evolution, Sergio Almecija, Melissa Tallman, Hesham M. Sallam, John G. Fleagle, Ashley S. Hammond, Erik R. Seiffert
Peer Reviewed Articles
The divergence of crown catarrhines—i.e., the split of cercopithecoids (Old World monkeys) from hominoids (apes and humans)—is a poorly understood phase in our shared evolutionary history with other primates. The two groups differ in the anatomy of the hip joint, a pattern that has been linked to their locomotor strategies: relatively restricted motion in cercopithecoids vs. more eclectic movements in hominoids. Here we take advantage of the first well-preserved proximal femur of the early Oligocene stem catarrhine Aegyptopithecus to investigate the evolution of this anatomical region using 3D morphometric and phylogenetically-informed evolutionary analyses. Our analyses reveal that cercopithecoids and hominoids …
Establishing Computational Approaches Towards Identifying Malarial Allosteric Modulators: A Case Study Of Plasmodium Falciparum Hsp70s, Arnold Amusengeri, Lindy Astl, Kevin Lobb, Gennady M. Verkhivker, Özlem Tastan Bishop
Establishing Computational Approaches Towards Identifying Malarial Allosteric Modulators: A Case Study Of Plasmodium Falciparum Hsp70s, Arnold Amusengeri, Lindy Astl, Kevin Lobb, Gennady M. Verkhivker, Özlem Tastan Bishop
Mathematics, Physics, and Computer Science Faculty Articles and Research
Combating malaria is almost a never-ending battle, as Plasmodium parasites develop resistance to the drugs used against them, as observed recently in artemisinin-based combination therapies. The main concern now is if the resistant parasite strains spread from Southeast Asia to Africa, the continent hosting most malaria cases. To prevent catastrophic results, we need to find non-conventional approaches. Allosteric drug targeting sites and modulators might be a new hope for malarial treatments. Heat shock proteins (HSPs) are potential malarial drug targets and have complex allosteric control mechanisms. Yet, studies on designing allosteric modulators against them are limited. Here, we identified allosteric …