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2022

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Full-Text Articles in Physical Sciences and Mathematics

Using Network Analysis To Contrast Three Models Of Student Forum Discussions, Hannah N. Benston Jan 2022

Using Network Analysis To Contrast Three Models Of Student Forum Discussions, Hannah N. Benston

Browse all Theses and Dissertations

There is much research about how actors and events in social networks affect each other. In this research, three network models were created for discussion forums in three semesters of undergraduate general physics courses. This study seeks to understand what social network measures are most telling of a online forum classroom dynamic. That is, I wanted to understand more about things like what students are most central to the networks and whether this is consistent across different network models. I also wanted to better understand how students may or may not group together. What relationships (student to student, student to …


Harmful Algal Blooms In Caesar Creek Lake And Their Relationship To Riparian Cover, Morgan C. Grunden Jan 2022

Harmful Algal Blooms In Caesar Creek Lake And Their Relationship To Riparian Cover, Morgan C. Grunden

Browse all Theses and Dissertations

Caesar Creek Lake (CCL) in Warren County, OH has recently been experiencing harmful algal blooms (HABs) which are most likely attributed to an excess of phosphorus (P) from fertilizers and manures applied to surrounding fields. Sediments act as a sink for P later supplying a source of P in lakes for HABs when waters become thermally stratified and anoxic. This study seeks to determine the relationship between HABs in CCL and riparian cover at the main tributaries, Anderson Fork and Caesar Creek. In order to do this, sediment samples were collected from four sample sites along Anderson Fork and three …


Recent Advances Toward Transparent Methane Emissions Monitoring: A Review, Broghan M. Erland, Andrew K. Thorpe, John Gamon Jan 2022

Recent Advances Toward Transparent Methane Emissions Monitoring: A Review, Broghan M. Erland, Andrew K. Thorpe, John Gamon

Department of Earth and Atmospheric Sciences: Faculty Publications

Given that anthropogenic greenhouse gas (GHG) emissions must be immediately reduced to avoid drastic increases in global temperature, methane emissions have been placed center stage in the fight against climate change. Methane has a significantly larger warming potential than carbon dioxide. A large percentage of methane emissions are in the form of industry emissions, some of which can now be readily identified and mitigated. This review considers recent advances in methane detection that allow accurate and transparent monitoring, which are needed for reducing uncertainty in source attribution and evaluating progress in emissions reductions. A particular focus is on complementary methods …


Saving, Investment, And Capital Markets In Developing Countries: A Look At Nepal And Tanzania, Aayush Aryal Jan 2022

Saving, Investment, And Capital Markets In Developing Countries: A Look At Nepal And Tanzania, Aayush Aryal

CISLA Senior Integrative Projects

No abstract provided.


The Chemical Characterization Of Microplastic Polymer Composition From Various Littoral Environments On Cape Cod, Massachusetts, Leah Kosovsky Jan 2022

The Chemical Characterization Of Microplastic Polymer Composition From Various Littoral Environments On Cape Cod, Massachusetts, Leah Kosovsky

Chemistry Honors Papers

The increasing abundance of microplastic pollution in marine environments is a rising concern, and it has the potential to negatively affect the health and sustainability of marine organisms and ecosystems. Microplastics can harm organisms through a variety of chemical, biological, and physical mechanisms. The extent to which they are harmful varies greatly and is significantly dependent on the chemical and physical makeup of the plastic polymer. Due to this variability, it is important to characterize microplastic samples in various environments to better understand the risks associated with the debris in certain areas. Through field research, a spatial analysis of the …


Investigating The Impacts Of Microgravity On Methanotrophic Bacteria Metabolism For Methane Gas Oxidation, Daisy Li, Elena Zhu, Stella Ristic '25, Joshua Suarez Jan 2022

Investigating The Impacts Of Microgravity On Methanotrophic Bacteria Metabolism For Methane Gas Oxidation, Daisy Li, Elena Zhu, Stella Ristic '25, Joshua Suarez

Distinguished Student Work

An abundance of waste methane gas is produced on the International Space Station (ISS) as a result of the Sabatier Reaction, a part of the Environmental Control and Life Support System (ECLSS). In order to manage this organic waste, this experiment seeks to understand how microgravity impacts the methane-oxidizing metabolism of methanotrophic bacteria, namely Methylorubrum podarium. As methanotrophs have never been studied in space, this investigation may unlock a novel understanding of their behavior in microgravity, leading to promising future applications such as improved life support systems in deep space. In this experiment, cameras will capture snapshots of the bacterial …


Maintaining Driveways, Lake Champlain Sea Grant Jan 2022

Maintaining Driveways, Lake Champlain Sea Grant

Lake Champlain Sea Grant Institute

This presentation produced by Lake Champlain Sea Grant's BLUE BTV initiative explains how driveways can contribute to stormwater and pollutant runoff into waterways, what cities, like Burlington, Vermont, are doing to encourage impervious driveways, and actions that individuals can take to maintain their own driveways to keep waterways clean.


Keeping Dogs Safe From Cyanobacteria Blooms (Habs), Lake Champlain Sea Grant Jan 2022

Keeping Dogs Safe From Cyanobacteria Blooms (Habs), Lake Champlain Sea Grant

Lake Champlain Sea Grant Institute

Cyanobacteria blooms (sometimes called Harmful Algal Blooms or HABs) are overgrowths of a type of bacteria that use sunlight to reproduce in lakes and ponds. Cyanobacteria blooms sometimes produce potent toxins that can poison people, pets, and livestock. The presence of these blooms is increasing in many areas, putting both animals and humans at risk.

This brochure will help you understand the risks, how to recognize cyanobacteria blooms, how to keep both you and your dog safe from exposure, as well as what to do if your dog has been exposed to a bloom or poisoned by toxins.


Best Lawn Care Practices, Lake Champlain Sea Grant Jan 2022

Best Lawn Care Practices, Lake Champlain Sea Grant

Lake Champlain Sea Grant Institute

Lawn care practices that contribute to a healthy lawn and better water quality are described.

Programs in Burlington, Vermont, are described.


Introducing Lake Champlain Sea Grant And Programs For Real Estate Professionals, Linda Patterson Jan 2022

Introducing Lake Champlain Sea Grant And Programs For Real Estate Professionals, Linda Patterson

Lake Champlain Sea Grant Institute

Lake Champlain Sea Grant offers accredited workshops to Vermont and New York real estate professionals. Real estate professionals are often the first (and sometimes only) source of information for buyers and sellers about construction and alterations in regulated areas (such as wetlands and river corridors), potential flood risks, septic requirements, shoreland protection, and related topics. Realtors also gain valuable information about state and local resources that they can pass on to their clients.

All courses award Vermont continuing education credits. New York credits are available for the septic course, with others pending. Courses are listed in the presentation.


Stormwater Subsurface Gravel Wetlands In Vermont: Permitting, Performance, And Chloride Concerns, Watershed Consulting Associates, Llc, University Of Vermont Jan 2022

Stormwater Subsurface Gravel Wetlands In Vermont: Permitting, Performance, And Chloride Concerns, Watershed Consulting Associates, Llc, University Of Vermont

Lake Champlain Sea Grant Institute

Subsurface gravel wetlands (SGW) are water treatment practices that utilize a saturated bed of gravel and (sometimes) wetland vegetation to filter incoming water and remove pollutants through a combination of physical filtration, adsorption, biological uptake, and microbial transformation. Water level is controlled by an outlet structure to retain a permanent subsurface pool, providing retention of stormwater volume in addition to pollutant removal. SGW are becoming increasingly popular tools for stormwater treatment in Vermont.

A varied group of partners including academic researchers, municipal stormwater managers, and consulting designers and engineers, have identified questions around stormwater gravel wetland performance as significant in …


Distribution Of Particulate Organic Carbon – Fluxes And Inventories – In Growth-Faulted Coastal Wetlands, Samuel Joel Whitehead Jan 2022

Distribution Of Particulate Organic Carbon – Fluxes And Inventories – In Growth-Faulted Coastal Wetlands, Samuel Joel Whitehead

Theses and Dissertations--Earth and Environmental Sciences

Coastal wetlands along the Northern Gulf of Mexico (NGOMx) are critically important but threatened environments which provide significant and diverse economic, social, and environmental value. These environments are essential components to the global carbon cycle, serving as one of the most efficient terrestrial carbon sinks. Since onset of the Industrial Revolution increasing rates of coastal wetland loss have been documented due to a variety of anthropogenic activities, neotectonic processes, subsidence, and rising sea-levels. This research utilized an array of methods and sedimentological analyses to test the hypothesis that growth-fault induced changes at Earth’s surface affects the delivery to, and storage …


The Revised Systematics And Paleoecology Of The Devonian Stemless Crinoid Genus Edriocrinus Hall, 1858, Catherine E. Herbert Jan 2022

The Revised Systematics And Paleoecology Of The Devonian Stemless Crinoid Genus Edriocrinus Hall, 1858, Catherine E. Herbert

Theses and Dissertations--Earth and Environmental Sciences

New morphological observations of Edriocrinus Hall, 1858, enable a modern, holistic view of this unusual crinoid genus, previously included in the Superorder Flexibilia (Zittel, 1895) Wright et al., 2017. Re-analysis of Edriocrinus suggests that the genus should now be assigned to the Order ‘Dendrocrinida’ within the Magnorder Eucladida Wright, 2017 based on the five infrabasals, single radianal in the cup, absent anal sac, and non-pinnulate arms with rectangular uniserial brachials. Moreover, examination of the slight variations separating the current 14 Edriocrinus species indicates that these “species” are likely ecophenotypes. The current Edriocrinus species are revised based on firmly bound calyx …


The Performance Optimization Of Asp Solving Based On Encoding Rewriting And Encoding Selection, Liu Liu Jan 2022

The Performance Optimization Of Asp Solving Based On Encoding Rewriting And Encoding Selection, Liu Liu

Theses and Dissertations--Computer Science

Answer set programming (ASP) has long been used for modeling and solving hard search problems. These problems are modeled in ASP as encodings, a collection of rules that declaratively describe the logic of the problem without explicitly listing how to solve it. It is common that the same problem has several different but equivalent encodings in ASP. Experience shows that the performance of these ASP encodings may vary greatly from instance to instance when processed by current state-of-the-art ASP grounder/solver systems. In particular, it is rarely the case that one encoding outperforms all others. Moreover, running an ASP system on …


The Lick Agn Monitoring Project 2016: Velocity-Resolved Hβ Lags In Luminous Seyfert Galaxies, Vivian U, Aaron J. Barth, H. Alexander Vogler, Hengxiao Guo, Tommaso Treu, Vardha N. Bennert, Gabriela Canalizo, Alexei V. Filippenko, Elinor Gates, Frederick Hamann, Michael D. Joner, Matthew A. Malkan, Anna Pancoast, Peter R. Williams, Jong-Hak Woo, Bela Abolfathi, L. E. Abramson, Stephen F. Armen, Hyun-Jin Bae, Thomas Bohn, Benjamin D. Boizelle, Azalee Bostroem, Andrew Brandel, Thomas G. Brink, Sanyum Channa, M. C. Cooper, Maren Cosens, Edward Donohue, Sean P. Fillingham, Diego González-Buitrago, Goni Halevi, Andrew Halle, Carol E. Hood, Keith Horne, J. Chuck Horst, Maxime De Kouchkovsky, Benjamin Kuhn, Sahana Kumar, Douglas C. Leonard, Donald Loveland, Christina Manzano-King, Ian Mchardy, Raúl Michel, Melanie Kae B. Olaes, Daeseong Park, Songyoun Park, Liuyi Pei, Timothy W. Ross, Jordan N. Runco, Jenna Samuel, Javier Sánchez, Bryan Scott, Remington O. Sexton, Jaejin Shin, Isaac Shivvers, Chance L. Spencer, Benjamin E. Stahl, Samantha Stegman, Isak Stomberg, Stefano Valenti, L. Villafaña, Jonelle L. Walsh, Heechan Yuk, Weikang Zheng Jan 2022

The Lick Agn Monitoring Project 2016: Velocity-Resolved Hβ Lags In Luminous Seyfert Galaxies, Vivian U, Aaron J. Barth, H. Alexander Vogler, Hengxiao Guo, Tommaso Treu, Vardha N. Bennert, Gabriela Canalizo, Alexei V. Filippenko, Elinor Gates, Frederick Hamann, Michael D. Joner, Matthew A. Malkan, Anna Pancoast, Peter R. Williams, Jong-Hak Woo, Bela Abolfathi, L. E. Abramson, Stephen F. Armen, Hyun-Jin Bae, Thomas Bohn, Benjamin D. Boizelle, Azalee Bostroem, Andrew Brandel, Thomas G. Brink, Sanyum Channa, M. C. Cooper, Maren Cosens, Edward Donohue, Sean P. Fillingham, Diego González-Buitrago, Goni Halevi, Andrew Halle, Carol E. Hood, Keith Horne, J. Chuck Horst, Maxime De Kouchkovsky, Benjamin Kuhn, Sahana Kumar, Douglas C. Leonard, Donald Loveland, Christina Manzano-King, Ian Mchardy, Raúl Michel, Melanie Kae B. Olaes, Daeseong Park, Songyoun Park, Liuyi Pei, Timothy W. Ross, Jordan N. Runco, Jenna Samuel, Javier Sánchez, Bryan Scott, Remington O. Sexton, Jaejin Shin, Isaac Shivvers, Chance L. Spencer, Benjamin E. Stahl, Samantha Stegman, Isak Stomberg, Stefano Valenti, L. Villafaña, Jonelle L. Walsh, Heechan Yuk, Weikang Zheng

Physics

We carried out spectroscopic monitoring of 21 low-redshift Seyfert 1 galaxies using the Kast double spectrograph on the 3 m Shane telescope at Lick Observatory from 2016 April to 2017 May. Targeting active galactic nuclei (AGNs) with luminosities of λLλ(5100 Å) ≈ 1044 erg s−1 and predicted Hβ lags of ∼20–30 days or black hole masses of 107–108.5 M⊙, our campaign probes luminosity-dependent trends in broad-line region (BLR) structure and dynamics as well as to improve calibrations for single-epoch estimates of quasar black hole masses. Here we present the first results from the campaign, including …


The Lick Agn Monitoring Project 2016: Velocity-Resolved Hβ Lags In Luminous Seyfert Galaxies, Vivian U, Aaron J. Barth, H. Alexander Vogler, Hengxiao Guo, Tommaso Treu, Vardha N. Bennert, Gabriela Canalizo, Alexei V. Filippenko, Elinor Gates, Frederick Hamann, Michael D. Joner, Matthew A. Malkan, Anna Pancoast, Peter R. Williams, Jong-Hak Woo, Bela Abolfathi, L. E. Abramson, Stephen F. Armen, Hyun-Jin Bae, Thomas Bohn, Benjamin D. Boizelle, Azalee Bostroem, Andrew Brandel, Thomas G. Brink, Sanyum Channa, M. C. Cooper, Maren Cosens, Edward Donohue, Sean P. Fillingham, Diego González-Buitrago, Goni Halevi, Andrew Halle, Carole E. Hood, Keith Horne, J. Chuck Horst, Maxime De Kouchkovsky, Benjamin Kuhn, Sahana Kumar, Douglas C. Leonard, Donald Loveland, Christina Manzano-King, Ian Mchardy, Raúl Michel, Melanie Kae B. Olaes, Daeseong Park, Songyoun Park, Liuyi Pei, Timothy W. Ross, Jordan N. Runco, Jenna Samuel, Javier Sánchez, Bryan Scott, Remington O. Sexton, Jaejin Shin, Isaac Shivvers, Chance L. Spencer, Benjamin E. Stahl, Samantha Stegman, Isak Stomberg, Stefano Valenti, L. Villafaña, Jonelle L. Walsh, Heechan Yuk, Weikang Zheng Jan 2022

The Lick Agn Monitoring Project 2016: Velocity-Resolved Hβ Lags In Luminous Seyfert Galaxies, Vivian U, Aaron J. Barth, H. Alexander Vogler, Hengxiao Guo, Tommaso Treu, Vardha N. Bennert, Gabriela Canalizo, Alexei V. Filippenko, Elinor Gates, Frederick Hamann, Michael D. Joner, Matthew A. Malkan, Anna Pancoast, Peter R. Williams, Jong-Hak Woo, Bela Abolfathi, L. E. Abramson, Stephen F. Armen, Hyun-Jin Bae, Thomas Bohn, Benjamin D. Boizelle, Azalee Bostroem, Andrew Brandel, Thomas G. Brink, Sanyum Channa, M. C. Cooper, Maren Cosens, Edward Donohue, Sean P. Fillingham, Diego González-Buitrago, Goni Halevi, Andrew Halle, Carole E. Hood, Keith Horne, J. Chuck Horst, Maxime De Kouchkovsky, Benjamin Kuhn, Sahana Kumar, Douglas C. Leonard, Donald Loveland, Christina Manzano-King, Ian Mchardy, Raúl Michel, Melanie Kae B. Olaes, Daeseong Park, Songyoun Park, Liuyi Pei, Timothy W. Ross, Jordan N. Runco, Jenna Samuel, Javier Sánchez, Bryan Scott, Remington O. Sexton, Jaejin Shin, Isaac Shivvers, Chance L. Spencer, Benjamin E. Stahl, Samantha Stegman, Isak Stomberg, Stefano Valenti, L. Villafaña, Jonelle L. Walsh, Heechan Yuk, Weikang Zheng

Physics

We carried out spectroscopic monitoring of 21 low-redshift Seyfert 1 galaxies using the Kast double spectrograph on the 3 m Shane telescope at Lick Observatory from 2016 April to 2017 May. Targeting active galactic nuclei (AGNs) with luminosities of λLλ(5100 Å) ≈ 1044 erg s−1 and predicted Hβ lags of ∼20–30 days or black hole masses of 107–108.5 M⊙, our campaign probes luminosity-dependent trends in broad-line region (BLR) structure and dynamics as well as to improve calibrations for single-epoch estimates of quasar black hole masses. Here we present the first results from the campaign, including …


Did They Really Tweet That?, Caleb Bradford, Michael L. Nelson (Mentor) Jan 2022

Did They Really Tweet That?, Caleb Bradford, Michael L. Nelson (Mentor)

Computer & Information Science: Research Experiences for Undergraduates in Disinformation Detection and Analytics

No abstract provided.


Developing A Virtual Modular Synthesizer For Sound Waves And Midi, Margaret Jagger Jan 2022

Developing A Virtual Modular Synthesizer For Sound Waves And Midi, Margaret Jagger

Senior Independent Study Theses

Modular synthesis involves the alteration and modification of digital sound signals. Thus, this modular synthesizer allows a user the option of supplying their own MIDI-compatible controller to serve as an input source, or to use the built-in pure sound waves instead. Either input will be fed into the domain-specific language SuperCollider and altered, with specific sound modifications dependent on the input source used. Using theoretical knowledge of the physics behind the motion of sound waves, various modules and functionalities are created. Then, with SuperCollider, these modules are implemented into a synthesizer which accepts either pure sound waves or MIDI as …


Sediment Survey: Yr070111, Station 3926, Clay Bank, York River Virginia, Grace M. Massey, Patrick J. Dickhudt, Carl T. Friedrichs Jan 2022

Sediment Survey: Yr070111, Station 3926, Clay Bank, York River Virginia, Grace M. Massey, Patrick J. Dickhudt, Carl T. Friedrichs

Data

This dataset consists of sediment properties including grain size distribution, percent moisture, percent organic matter, sediment bed erodibility, as well as (in most cases) x-ray images of the sediment structure. Most samples were taken in support of an Acoustic Doppler Velocimeter (ADV) tripod deployed in nearby location.


What Uae Software Students Think About Software Testing: A Replicated Study, Luiz Fernando Capretz, Saad Harous, Ali Bou Nassif Jan 2022

What Uae Software Students Think About Software Testing: A Replicated Study, Luiz Fernando Capretz, Saad Harous, Ali Bou Nassif

Electrical and Computer Engineering Publications

Software testing is vital to improve software quality. However, software tester role is stigmatized, partly due to misperception and partly due to the treatment of the testing process within the software industry. The present study analyses this situation aiming to explore what might inhibit an individual from taking up a software testing career. In order to investigate this issue, we surveyed 132 senior students pursuing degrees in information systems, information and communication technology, computer science, computer engineering, software engineering, and other closely-related disciplines at three universities in the United Arab Emirates: two publicly funded and one top-notch private university. The …


Extremely Broad Ly Α Line Emission From The Molecular Intragroup Medium In Stephan's Quintet: Evidence For A Turbulent Cascade In A Highly Clumpy Multiphase Medium?, P. Guillard, P. N. Appleton, F. Boulanger, J. M. Shull, M. D. Lehnert, G. Pineau Des Forets, E. Falgarone, M. E. Cluver, C. K. Xu, Sarah C. Gallagher, P. A. Duc Jan 2022

Extremely Broad Ly Α Line Emission From The Molecular Intragroup Medium In Stephan's Quintet: Evidence For A Turbulent Cascade In A Highly Clumpy Multiphase Medium?, P. Guillard, P. N. Appleton, F. Boulanger, J. M. Shull, M. D. Lehnert, G. Pineau Des Forets, E. Falgarone, M. E. Cluver, C. K. Xu, Sarah C. Gallagher, P. A. Duc

Physics and Astronomy Publications

We present Hubble Space Telescope Cosmic Origin Spectrograph (COS) UV line spectroscopy and integral-field unit (IFU) observations of the intragroup medium in Stephan's Quintet (SQ). SQ hosts a 30 kpc long shocked ridge triggered by a galaxy collision at a relative velocity of 1000 km s-1, where large amounts of molecular gas coexist with a hot, X-ray-emitting, plasma. COS spectroscopy at five positions sampling the diverse environments of the SQ intragroup medium reveals very broad (≈2000 km s-1) Lyα line emission with complex line shapes. The Lyα line profiles are similar to or much broader than those of Hβ, [C …


Survey Analysis: Senior And One-Year Out Surveys, Paige Phillips Jan 2022

Survey Analysis: Senior And One-Year Out Surveys, Paige Phillips

Computer Science: Student Scholarship & Creative Works

Through surveys colleges are able to collect and analyze data pertaining to the institution's alumni, including valuable information about employment post-graduation. The number of alumni employed after graduation is an important statistic for colleges. In addition, the location, company, industry sector, and relevance to major are other aspects that can be analyzed by the college. Collecting alumni information not only provides pertinent employment status but can also maintain alumni connections. Therefore, this project works to organize and analyze alumni major feedback collected through alumni surveys, in order to provide pertinent information for departments and the college.


The Effects Of Floodplain Restoration On Biodiversity, Ireland Keeney, Jessica Gutekunst Jan 2022

The Effects Of Floodplain Restoration On Biodiversity, Ireland Keeney, Jessica Gutekunst

Summer Scholarship, Creative Arts and Research Projects (SCARP)

During the colonial era, numerous mills and dams were built in Pennsylvania. This and other intensive land uses led to sediment eroding from upstream and burying wetlands. The accumulated sediment is known as legacy sediment1.

There has been a significant loss of wetlands throughout the centuries, with many of them in the Piedmont region being buried under thick layers of legacy sediment as shown in Figure 1 below2.

The removal of legacy sediment is a new technique used to restore wetlands, mainly with the intent being to improve water quality3. However, a restored wetland as shown by Figure 1 may …


Development Of Sensitive And Fast Immunoassay For Lyme Disease, Justin Cosgrove Jan 2022

Development Of Sensitive And Fast Immunoassay For Lyme Disease, Justin Cosgrove

Summer Scholarship, Creative Arts and Research Projects (SCARP)

Testing for Lyme disease has proven to be time consuming and inaccurate, especially in its early stages. The goal of this project is to develop a new diagnostic that has improved timeliness, sensitivity, and selectivity. This test is based on an enzyme-linked immunosorbent assay, or ELISA. To improve on what is currently in place, magnetic beads will be used. Unlike a normal ELISA, these magnetic beads are the binding site of the capture antibody instead of the microplate surface. With greatly increased surface area from the beads, the process can be much faster and detect far lesser concentrations of protein …


Encapsulation Of Molecular Probes In Polymer Nanoparticles For Visual Detection Of Heavy Metals In Water, Kyla Dewittie Jan 2022

Encapsulation Of Molecular Probes In Polymer Nanoparticles For Visual Detection Of Heavy Metals In Water, Kyla Dewittie

Summer Scholarship, Creative Arts and Research Projects (SCARP)

Heavy metal contamination is a problem worldwide, and it has dangerous effects on humans and the environment. Lead is one of the most common metal toxins due to its presence in a variety of household items including paint and pipes. Mercury is another common toxin that is dangerous due to its long half-life which causes it to buildup in not only water sources, but also inhabiting wildlife. The consumption of both metals is detrimental to human health, therefore proper detection methods are needed. Various detection methods exist but are not cost or time efficient. Molecular probes could be a solution …


Luminescence From Metal-Organic Frameworks: Structural Modification And Small Molecule Uptake, Nicholas A. Erisman, Brandon A. Molina Jan 2022

Luminescence From Metal-Organic Frameworks: Structural Modification And Small Molecule Uptake, Nicholas A. Erisman, Brandon A. Molina

Summer Scholarship, Creative Arts and Research Projects (SCARP)

Metal-Organic Frameworks (MOFs) are materials that contain metal centers coordinated by organic molecules that form an extended, porous lattice. These MOFs are of interest in the field of sensing for their unique properties such as high stability, high surface area, high crystallinity, and ability to perform small molecule exchange. Luminescent metal-organic frameworks (LMOFs) are of specific interest since they contain the potential to detect volatile organic compounds via adsorption into the porous framework. 1 Luminescent properties can be imparted to MOFs in several ways. Previous projects focused on the inclusion of the luminescent osmium complex Os(dcphen)(CO)2 (Cl)2 (dcphen = 1,10-phenanthroline-4,7-dicarboxylic …


Synthesis Of Asymmetrically-Substituted Tetraphenyl-Class Porphyrins, William J. Davis Jan 2022

Synthesis Of Asymmetrically-Substituted Tetraphenyl-Class Porphyrins, William J. Davis

Summer Scholarship, Creative Arts and Research Projects (SCARP)

Porphyrins are macrocyclic compounds that can be synthesized and used in photodynamic therapy (PDT), a noninvasive and selective method designed to eliminate diseased tissue (such as cancer) without killing healthy tissue. PDT involves the following three steps. A photosensitizer enters a cancerous cell, is excited by electromagnetic radiation, and transfers the energy to molecular oxygen which is then converted into singlet oxygen, which triggers cellular apoptosis. However, for a porphyrin to be utilized as a therapeutic in PDT, it must satisfy the following two criteria: the porphyrin needs to possess the correct solubility to pass through the cell membrane and …


Optimization Of The Control Line On A Lateral Flow Assay For Lead (Ii) Detection In Drinking Water, Yudeliz Sanchez Jan 2022

Optimization Of The Control Line On A Lateral Flow Assay For Lead (Ii) Detection In Drinking Water, Yudeliz Sanchez

Summer Scholarship, Creative Arts and Research Projects (SCARP)

According to a recent survey by the United States Environmental Protection Agency (EPA), there are between 6 to 10 million lead (Pb2+) service lines in the country. Consumption of lead can cause brain and kidney damage. Our goal is to create a simple, inexpensive paper-based assay to make lead testing accessible. Lateral flow assays (LFAs) are rapid tests (5-30 mins) used to detect or quantify analytes in mixtures. Each LFA has a control line and a test line(s). The control line ensures the test is working. In our test, the control line is composed of neutral red polymer nanoparticles, which …


Design And Synthesis Of Hoogsteen-Binding Peptide Nucleic Acid Monomers With Extended Linkers For Triple Helical U-A Recognition In Rna, Angelina B. Giglio-Tos, Tristan L. Mabee, James A. Mackay Jan 2022

Design And Synthesis Of Hoogsteen-Binding Peptide Nucleic Acid Monomers With Extended Linkers For Triple Helical U-A Recognition In Rna, Angelina B. Giglio-Tos, Tristan L. Mabee, James A. Mackay

Summer Scholarship, Creative Arts and Research Projects (SCARP)

RNA provides many functions within biological systems. For example, noncoding RNA (ncRNA), a form of RNA that is not part of transcription or translation, serves a variety of unique roles, such as catalysis or gene regulation. ncRNA generally forms double helical motifs that are ripe for molecular recognition. Sequence selective recognition of double helical RNA (dhRNA) can be achieved using Peptide Nucleic Acids (PNA) through triple helical formation by Hoogsteen hydrogen bonding of PNA nucleobases in the major groove of dhRNA. However, strong, and selective recognition is typically limited to polypurine strands and pyrimidine recognition remains an unsolved problem. A …


Creation Of A Cell Line For Rapid Identification Of Potential Receptor Agonists Or Antagonists, Brandon Baxter Jan 2022

Creation Of A Cell Line For Rapid Identification Of Potential Receptor Agonists Or Antagonists, Brandon Baxter

Summer Scholarship, Creative Arts and Research Projects (SCARP)

Developing drugs to combat disease is costly and time-consuming. Efficient methods for rapid drug screening for diseases such as Type 2 diabetes mellitus or cancer would be extremely advantageous. Diabetes effects 33.3 million people in the United States and 462 million worldwide and 17 million new cases of cancer are diagnosed each year. Many diseases result from the cells inability to respond to external signals that bind to receptors on the cytoplasmic membrane. This research attempted to create a cell line containing an intracellular protein fused to GFP. This protein would alter its cellular location and serve as an indicator …