Physical Sciences and Mathematics Commons^™

Identifying The Serious Clinical Outcomes Of Adverse Reactions To Drugs By A Multi-Task Deep Learning Framework, Haochen Zhao, Peng Ni, Qichang Zhao, Xiao Liang, Di Ai, Shannon Erhardt, Jun Wang, Yaohang Li, Jiianxin Wang

Computer Science Faculty Publications

Adverse Drug Reactions (ADRs) have a direct impact on human health. As continuous pharmacovigilance and drug monitoring prove to be costly and time-consuming, computational methods have emerged as promising alternatives. However, most existing computational methods primarily focus on predicting whether or not the drug is associated with an adverse reaction and do not consider the core issue of drug benefit-risk assessment-whether the treatment outcome is serious when adverse drug reactions occur. To this end, we categorize serious clinical outcomes caused by adverse reactions to drugs into seven distinct classes and present a deep learning framework, so-called GCAP, for predicting the …

Dynamic Discounted Satisficing Based Driver Decision Prediction In Sequential Taxi Requests, Sree Pooja Akula

Masters Theses

"Ridesharing platforms rely on connecting available taxi drivers to potential passengers to maximize their revenue. However, predicting the stopping decision made by every driver, i.e., the final task performed during a given day, is crucial to achieving this goal. Unfortunately, little research has been done on predicting drivers’ stopping decisions, especially when they deviate from expected utility maximization behavior. This research proposes a Dynamic Discounted Satisficing (DDS) heuristic to model and learn the task at which human agents will stop working for that day, assuming that the human agents are taking sequential decisions based on their preference order. We apply …

Investigation Of Defect Production And Displacement Energies In Wurtzite Aluminum Nitride, Sean Anderson

Masters Theses

"Aluminum Nitride is an active element of sensors that monitor the performance and well-being of the nuclear reactors due to its piezoelectric properties. Yet, the variations of its properties under irradiation are largely unexplored. We report the results of the molecular dynamics simulations of the structural changes in AlN under irradiation via the knock-on atom technique. By creating and evolving the irradiation cascades due to energetic particle interaction with the atom of the crystalline lattice we determine the rate of the defect production as a function of the deposited energy. Further, we determine a displacement energy, a key characteristic that …

The Application Of Statistical Modeling To Identify Genetic Associations With Mild Traumatic Brain Injury Outcomes, Caroline Schott

Masters Theses

"Traumatic brain injury (TBI) is a growing health concern, with millions of TBI diagnoses in the United States each year. The vast majority of TBI diagnoses are mild traumatic brain injuries (mTBI), which can be challenging to manage due to variation in symptoms and outcomes. Most individuals with mTBI successfully recover quickly, but a small subset has a delayed recovery. Although the factors that contribute to this variation in recovery are not clearly understood, it is possible that genetic differences may play a role. Very few studies have investigated the association between single nucleotide polymorphisms (SNPs) with mTBI outcomes and …

Dfhic: A Dilated Full Convolution Model To Enhance The Resolution Of Hi-C Data, Bin Wang, Kun Liu, Yaohang Li, Jianxin Wang

Computer Science Faculty Publications

Motivation: Hi-C technology has been the most widely used chromosome conformation capture(3C) experiment that measures the frequency of all paired interactions in the entire genome, which is a powerful tool for studying the 3D structure of the genome. The fineness of the constructed genome structure depends on the resolution of Hi-C data. However, due to the fact that high-resolution Hi-C data require deep sequencing and thus high experimental cost, most available Hi-C data are in low-resolution. Hence, it is essential to enhance the quality of Hi-C data by developing the effective computational methods.

Results: In this work, we propose …

Mitigating Anomalous Electricity Consumption In Smart Cities Using An Ai-Based Stacked-Generalization Technique, Arshid Ali, Laiq Khan, Nadeem Javaid, Safdar Hussain Bouk, Abdulaziz Aldegheishem, Nabil Alrahjeh

Computer Science Faculty Publications

Energy management and efficient asset utilization play an important role in the economic development of a country. The electricity produced at the power station faces two types of losses from the generation point to the end user. These losses are technical losses (TL) and non-technical losses (NTL). TLs occurs due to the use of inefficient equipment. While NTLs occur due to the anomalous consumption of electricity by the customers, which happens in many ways; energy theft being one of them. Energy theft majorly happens to cut down on the electricity bills. These losses in the smart grid (SG) are the …

The Birds And The Trees: Quantifying The Drivers Of Whitebark Pine Decline And Clark's Nutcracker Habitat Use In Glacier National Park, Vladimir Kovalenko

Graduate Student Theses, Dissertations, & Professional Papers

Whitebark pine (Pinus albicaulis), recently listed as threatened under the Endangered Species Act, is in steep decline in Glacier National Park, Montana, USA due to the non-native pathogen Cronartium ribicola, causal agent of the fatal disease white pine blister rust. A sample of the park’s population suggests that approximately 70 percent of whitebark pines have died, while 65 percent of the remaining trees are infected. Using landscape and climate variables, we show how geographic location, elevation, aspect, solar radiation, relative humidity, and snowpack interact with tree diameter to affect mortality, disease incidence, cone production, and regeneration. We also examine how …

Synthetic Aperture Radar Observations At Salar De Pajonales, Chile, Michael A. A. Mcinenly

Graduate Student Theses, Dissertations, & Professional Papers

Remotely sensed microwave radars provide the spatial and temporal coverage needed to improve our understanding of the relationship between moisture content and salt pan mineralogy and, ultimately, climate variability. Moisture content in the surface and near-surface crusts found in salt pan environments, such as salt pan, has a significant impact on the backscatter values recorded by synthetic aperture radar (SAR) systems. This is because moisture affects the dielectric constant and surface roughness of the saline surface, which in turn influences the amount of electromagnetic energy reflected back to the SAR sensor. Changes in backscatter values are attributed to seasonal and …

Evaluating The Use Of Environmental Tracers To Reduce Conceptual Model Uncertainty Of Hydrogeologic Models, Andrew Nordberg, Jon Graham, W. Payton Gardner

Graduate Student Theses, Dissertations, & Professional Papers

Environmental tracer concentrations for CFC12, SF6, and tritium are used in groundwater simulations to assess the ability of these tracers to reduce conceptual model uncertainty due to uncertainty of a site’s geologic and recharge characterization. The resulting groundwater simulations are characterized by site-specific hydrologic and geologic data, and with coordination from a field team with years of knowledge about the site. First-order (conceptual) uncertainty is directly addressed by using a stochastic modeling approach for spatial variability of the proposed subsurface configurations. Simulations of environmental tracer concentrations and water levels are used to assess six alternate conceptual models that are based …

Meta-Analysis Of Scent Detection Canines And Potential Factors Influencing Their Success Rates, Molly Marie Jaskinia

Graduate Student Theses, Dissertations, & Professional Papers

Objective: This is a meta-analysis focused on the success rates of scent detection canines and potential factors that could influence their accuracy. A series of statistical analyses were conducted to determine if certain demographic factors, such as the dog’s gender, age, and breed, have an effect on a scent dog’s accuracy during a search. Or if more circumstantial factors, like the dog’s level of experience in scent work, the type of target scent, and their handler’s awareness of the target’s location, affect the outcome of the search.

Materials and Methods: A dataset was created from 37 different articles consisting of …

2-Aminopyridyl Functionalized Scaffold As A Tool For Systematic Investigation Of B-Glucan Binding And Dectin-1 Activation, Jasper Alinea Aquino

Graduate Student Theses, Dissertations, & Professional Papers

Tuberculosis (TB) – an infectious disease caused by Mycobacterium tuberculosis (Mtb) – remains an epidemic worldwide contributing to millions of deaths each year. Vaccination is possibly the best means of addressing this global threat. In recent years, synergistic Th1 and Th17 immune responses have emerged as the key players for a vaccine-induced protection against TB. There is currently no vaccine approved for humans that elicits a Th17-mediated immune response. C-Type Lectin Receptors (CLR), specifically Dectin-1, a pattern recognition receptor (PRR) of β-1,3-glucans (β-glucans) primarily from fungi cell walls, is known to induce a Th17-mediated response. The Th17 response upon binding …

Beaver Dam Analogs (Bdas) Alter Carbon Pools, Fluxes, And Concentrations Of Intermountain Headwater Streams, Hilary Schultz

Graduate Student Theses, Dissertations, & Professional Papers

Beaver dam analogs (BDAs) have emerged as a climate adaptation and restoration strategy for water resource management in the drought-prone Western U.S., yet the focus has been on their influence on water quantity, overlooking effects on broader ecological components. By increasing water residence time and facilitating sediment retention, BDAs have the potential to influence carbon pools, fluxes, and concentrations. To examine the influence of BDAs on instream and riparian organic C and trace gases, we studied three intermountain headwater streams restored with BDAs two years after restoration during the summer of 2021. We found that there were subtle differences in …

Evaluating The Relative Influence Of Soil Water Potential, Soil Moisture, And Vapor Pressure Deficit On Semi-Arid Vegetation Dynamics, Kayla R. Jamerson

Graduate Student Theses, Dissertations, & Professional Papers

Knowledge of vegetation’s response to soil water availability and atmospheric demand is critical to understanding the impact of climate change on semi-arid ecosystems. However, limited field-based research has been conducted to assess the relative importance of these drivers and previous research has simplified the assessment of soil water availability by relying on soil volumetric water content (VWC) as a primary control on plant growth, which, as opposed to soil water potential (Ψsoil), does not account for the effects of soil texture on plant available water. To address these gaps, we compared remotely sensed indicators of vegetation response to field based …

Assessing The Impact Of Parallel Burnout Fires On Flank Rate Of Spread, Erik Borke

Graduate Student Theses, Dissertations, & Professional Papers

The effects of flank-parallel suppression fires on the local rate of spread (ROS) of freely burning headfires through fully cured homogeneous grass fuels are assessed. Data sets include: one thermal image stack of a prescribed burn recorded by drone, and a suite of simulation experiments carried out in Wildland Urban Interface Fire Dynamics Simulator (WFDS). A new approach to computing ROS, curvature proxy driven normals to convex polylines, was developed to carry out this analysis. ROS time series depicting flank acceleration of the prescribed burn and simulation experiments, observable under coarse and fine directional classification schemes respectively, are the primary …

Displacement, Place Attachment, And Other Characteristics Of Anglers On The Yellowstone River, Zachary L. Jones

Graduate Student Theses, Dissertations, & Professional Papers

Yellowstone River has seen increasing recreational use as Montana has grown and out of state visitation has increased, leading to some locals voicing concerns of crowding. River recreation, as with many outdoor recreational activities, has participants that may be considered to be sensitive to crowded conditions and place a high value on solitude. Considering these perceptions, there is reason to believe that these participants may change their river use patterns if or when the perceived level of crowding exceeds their tolerance thresholds. Further, monitoring efforts conducted at river access sites often do not fully capture users that are already displaced …

Investigating Elastic Deformation Induced By Surface Loads On Planetary Bodies, Ashlesha Khatiwada, Hilary Martens, Donald F. Argus

Graduate Student Theses, Dissertations, & Professional Papers

Planetary bodies, including the Earth, deform when there is a redistribution of surface load. In this thesis, I conduct three independent projects related to surface loading, two of which investigate methods related to the modeling of surface loading and one which seeks to catalog the displacement responses of other planetary bodies to a surface load.

The first project aims to compare four methods for modeling the elastic loading response of the Earth: a homogeneous, non-gravitating, half-space method; a homogeneous, gravitating, spherical method; a homogeneous, non-gravitating spherical method; and a radially stratified gravitating spherical method. Many studies have focused on computing …

Climatological, Hydrological, And Economic Analysis Of Agriculture In Montana And The Western U.S.A., Zachary H. Lauffenburger

Graduate Student Theses, Dissertations, & Professional Papers

Many studies have addressed the impact of climate on agriculture; however, fewer studies addressed how farmers adapt to climate change, to what extent implementation of adaptation strategies mitigates economic losses or alters the hydrologic system. Analyses of how historical climate affected not only farmer decision making, but also the economic and hydrological consequences of farmers’ adaptations to climate variations, and projections of the spatiotemporal climatic regimes at finer regional scales are critical for aiding in actionable climate change adaptations. This dissertation helps fill knowledge gaps on the impacts of climate change in rural regions of the agricultural western U.S.A. and …

Evaluating The Sensitivity Of Crustal Deformation To Bedrock Hydrology In A Mountain Watershed, Brett J. Oliver

Graduate Student Theses, Dissertations, & Professional Papers

We evaluate the sensitivity of Earth's elastic deformation to groundwater hydraulic diffusivity using coupled groundwater and elastic deformation models. Seasonal changes in terrestrial water storage cause deformation to the Earth’s crust and deeper interior that is within the observational capacity of GPS instruments. We couple finite difference groundwater simulations with geodetic forward models of crustal displacement to investigate the ability of geodetic deformation to constrain bedrock hydrologic properties. We use MODFLOW-2005 to simulate seasonal changes in groundwater flow and storage, and then use the LoadDef elastic deformation model to forward model surface displacement caused by the change in terrestrial water …

N-Cylindrical Fuzzy Neutrosophic Topological Spaces, Sarannya Kumari R, Sunny Joseph Kalayathankal, Mathews George, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

The objective of this study is to incorporate topological space into the realm of n-Cylindrical Fuzzy Neutrosophic Sets (n-CyFNS), which are the most novel type of fuzzy neutrosophic sets. In this paper, we introduce n-Cylindrical Fuzzy Neutrosophic Topological Spaces (n-CyFNTS), n-Cylindrical Fuzzy Neutrosophic (n-CyFN) open sets, and n-CyFN closed sets. We also defined the n-CyFN base, n-CyFN subbase, and some related theorems here.

Special Subset Linguistic Topological Spaces, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In this book, authors, for the first time, introduce the new notion of special subset linguistic topological spaces using linguistic square matrices. This book is organized into three chapters. Chapter One supplies the reader with the concept of ling set, ling variable, ling continuum, etc. Specific basic linguistic algebraic structures, like linguistic semigroup linguistic monoid, are introduced. Also, algebraic structures to linguistic square matrices are defined and described with examples. For the first time, non-commutative linguistic topological spaces are introduced. The notion of a linguistic special subset of doubly non-commutative topological spaces of linguistic topological spaces is introduced in this …

Interactions Of Bioactive Trace Metals In Shipboard Southern Ocean Incubation Experiments, Shannon M. Burns, Randelle M. Bundy, William Abbott, Zuzanna Abdala, Alexa R. Sterling, P. Dreux Chappell, Bethany D. Jenkins, Kristen N. Buck

OES Faculty Publications

In the Southern Ocean, it is well‐known that iron (Fe) limits phytoplankton growth. Yet, other trace metals can also affect phytoplankton physiology. This study investigated feedbacks between phytoplankton growth and dissolved Fe, manganese (Mn), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), and cadmium (Cd) concentrations in Southern Ocean shipboard incubations. Three experiments were conducted in September–October 2016 near the West Antarctic Peninsula: Incubations 1 and 3 offshore in the Antarctic Circumpolar Current, and Incubation 2 inshore in Bransfield Strait. Additions of Fe and/or vitamin B₁₂ to inshore and offshore waters were employed and allowed assessment of metal (M) …

The Importance Of Winter Dinoflagellate Blooms In Chesapeake Bay— A Missing Link In Bay Productivity, Nicole C. Millette, Sophie Clayton, Margaret R. Mulholland, Leah Gibala-Smith, Michael Lane

OES Faculty Publications

It is widely assumed that phytoplankton abundance and productivity decline during temperate winters because of low irradiance and temperatures. However, winter phytoplankton blooms commonly occur in temperate estuaries, but they are often undocumented because of reduced water quality monitoring in winter. The small body of in situ work that has been done on winter blooms suggests they can be of enormous consequence to ecosystems. However, because monitoring is often reduced or stopped altogether during winter, it is unclear how widespread these blooms are or how long they can last. We analyzed an over 30-year record of monthly phytoplankton monitoring samples …

Atmospheric Input And Seasonal Inventory Of Dissolved Iron In The Sargasso Sea: Implications For Iron Dynamics In Surface Waters Of The Subtropical Ocean, Peter N. Sedwick, Bettina M. Sohst, K. N. Buck, S. Caprara, R. J. Johnson, D. C. Ohnemus, L. E. Sofen, A. Tagliabue, B. S. Twining, Tara E. Williams

OES Faculty Publications

Constraining the role of dust deposition in regulating the concentration of the essential micronutrient iron in surface ocean waters requires knowledge of the flux of seawater-soluble iron in aerosols and the replacement time of dissolved iron (DFe) in the euphotic zone. Here we estimate these quantities using seasonally resolved DFe data from the Bermuda Atlantic Time-series Study region and weekly-scale measurements of iron in aerosols and rain from Bermuda during 2019. In response to seasonal changes in vertical mixing, primary production and dust deposition, surface DFe concentrations vary from ∼0.2 nM in early spring to >1 nM in late summer, …

Sediment Delivery To Sustain The Ganges-Brahmaputra Delta Under Climate Change And Anthropogenic Impacts, Jessica L. Raff, Steven L. Goodbred Jr., Jennifer L. Pickering, Ryan S. Sincavage, John C. Ayers, Md. Saddam Hossain, Carol A. Wilson, Chris Paola, Michael S. Steckler, Dhiman R. Mondal, Jean-Louis Grimaud, Celine Jo Grall, Kimberly G. Rogers, Kazi Matin Ahmed, Syed Jo Grall, Kimberly G. Rogers, Kazi Matin Ahmed, Syed Humayun Akhter, Brandee N. Carlson, Elizabeth L. Chamberlain, Meagan Dejter, Jonathan M. Gilligan, Richard P. Hale, Mahfuzur R. Khan, Md. Golam Muktadir, Md. Munsur Rahman, Lauren A. Williams

OES Faculty Publications

The principal nature-based solution for offsetting relative sea-level rise in the Ganges-Brahmaputra delta is the unabated delivery, dispersal, and deposition of the rivers’ ~1 billion-tonne annual sediment load. Recent hydrological transport modeling suggests that strengthening monsoon precipitation in the 21st century could increase this sediment delivery 34-60%; yet other studies demonstrate that sediment could decline 15-80% if planned dams and river diversions are fully implemented. We validate these modeled ranges by developing a comprehensive field-based sediment budget that quantifies the supply of Ganges-Brahmaputra river sediment under varying Holocene climate conditions. Our data reveal natural responses in sediment supply comparable to …

Isotopic Evidence For Sources Of Dissolved Carbon And The Role Of Organic Matter Respiration In The Fraser River Basin, Canada, Britta M. Voss, Timothy I. Eglinton, Bernhard Peucker-Ehrenbrink, Valier Galy, Susan Q. Lang, Cameron Mcintyre, Robert G.M. Spencer, Ekaterina Bulygina, Zhaohui Aleck Wang, Katherine A. Guay

OES Faculty Publications

Sources of dissolved and particulate carbon to the Fraser River system vary significantly in space and time. Tributaries in the northern interior of the basin consistently deliver higher concentrations of dissolved organic carbon (DOC) to the main stem than other tributaries. Based on samples collected near the Fraser River mouth throughout 2013, the radiocarbon age of DOC exported from the Fraser River does not change significantly across seasons despite a spike in DOC concentration during the freshet, suggesting modulation of heterogeneous upstream chemical and isotopic signals during transit through the river basin. Dissolved inorganic carbon (DIC) concentrations are highest in …

Impact Of Atmospheric Correction On Classification And Quantification Of Seagrass Density From Worldview-2 Imagery, Victoria J. Hill, Richard C. Zimmerman, Paul Bissett, David Kohler, Blake Schaeffer, Megan Coffer, Jiang Li, Kazi Aminul Islam

OES Faculty Publications

Mapping the seagrass distribution and density in the underwater landscape can improve global Blue Carbon estimates. However, atmospheric absorption and scattering introduce errors in space-based sensors’ retrieval of sea surface reflectance, affecting seagrass presence, density, and above-ground carbon (AGC_seagrass) estimates. This study assessed atmospheric correction’s impact on mapping seagrass using WorldView-2 satellite imagery from Saint Joseph Bay, Saint George Sound, and Keaton Beach in Florida, USA. Coincident in situ measurements of water-leaving radiance (L_w), optical properties, and seagrass leaf area index (LAI) were collected. Seagrass classification and the retrieval of LAI were compared after empirical line …

Five Years Measuring The Muck: Evaluating Interannual Variability Of Nutrient Loads From Tidal Flooding, Alfonso Macías-Tapia, Margaret R. Mulholland, Corday R. Selden, J. Derek Loftis, Peter W. Bernhardt

OES Faculty Publications

Due to sea level rise, tidal flooding is now common in low-lying coastal systems around the world. Yet, the contribution of tidal flooding to non-point source nutrient loads and their impact on the quality of adjacent waters remains poorly constrained. Here, we quantified dissolved nutrient loading and Enterococcus abundance during annual autumnal king tides (i.e., perigean spring tides), between 2017 and 2021, in a sub-watershed of the lower Chesapeake Bay. To calculate nutrient loading from tidal flooding, we used geospatial inundation depths from a street-level hydrodynamic model to estimate floodwater volumes during each of the five sampling events and the …

Opioid Use Disorder Prediction Using Machine Learning Of Fmri Data, A. Temtam, Liangsuo Ma, F. Gerard Moeller, M. S. Sadique, K. M. Iftekharuddin, Khan M. Iftekharuddin (Ed.), Weijie Chen (Ed.)

Electrical & Computer Engineering Faculty Publications

According to the Centers for Disease Control and Prevention (CDC) more than 932,000 people in the US have died since 1999 from a drug overdose. Just about 75% of drug overdose deaths in 2020 involved Opioid, which suggests that the US is in an Opioid overdose epidemic. Identifying individuals likely to develop Opioid use disorder (OUD) can help public health in planning effective prevention, intervention, drug overdose and recovery policies. Further, a better understanding of prediction of overdose leading to the neurobiology of OUD may lead to new therapeutics. In recent years, very limited work has been done using statistical …

Systemic Analyses Of Radiocarbon Ages Of Coexisting Planktonic Foraminifera, Jörg Lippold, Julia Gottschalk, Jean Lynch-Stieglitz, Matthew W. Schmidt, Sönke Szidat, Andre Bahr

OES Faculty Publications

We compare radiocarbon (¹⁴C) ages of coexisting planktonic foraminifera species from sediment cores VM12-107 and KNR166-2-26JPC from the Equatorial Atlantic Ocean for three time periods (Holocene, Heinrich Stadial 1, last glacial maximum). We find a maximum inter-species difference of 1200 ¹⁴C yr. On average, the ¹⁴C ages deviate by ∼300 yr between Globigerinoides ruber and other species. In most cases, this exceeds the analytical uncertainty range of the measurements and thus renders the choice of species for generating age models as important as sample weight. While modern stratified water-column profiles imply an increase in ¹⁴C …

Sea Ice Formation, Glacial Melt And The Solubility Pump Boundary Conditions In The Ross Sea, Brice Loose, Sharon Stammerjohn, Peter Sedwick, Stephen Ackley

OES Faculty Publications

Seasonal formation of Dense Shelf Water (DSW) in the Ross Sea is a direct precursor to Antarctic Bottom Water, which fills the deep ocean with atmospheric gases in what composes the southern limb of the solubility pump. Measurements of seawater noble gas concentrations during katabatic wind events in two Ross Sea polynyas reveal the physical processes that determine the boundary value properties for DSW. This decomposition reveals 5–6 g kg⁻¹ of glacial meltwater in DSW and sea-ice production rates of up to 14 m yr⁻¹ within the Terra Nova Bay polynya. Despite winds upwards of 35 m s …