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2023

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Articles 12301 - 12330 of 12566

Full-Text Articles in Physical Sciences and Mathematics

Examining The Effects Of Seed Mix Diversity And Composition, Biochar Application, Seeding Rate, Species Identity, And Topography On Palouse Prairie Restoration, Thurman Johnson Jan 2023

Examining The Effects Of Seed Mix Diversity And Composition, Biochar Application, Seeding Rate, Species Identity, And Topography On Palouse Prairie Restoration, Thurman Johnson

EWU Masters Thesis Collection

With over 99.9% of the Palouse prairie lost to land conversion, restoring native plant communities is crucial for ecological function, however, research on Palouse prairie restoration methods is sparse. Seed-based restoration uses a mix of seeded species to enhance competition against weeds, diversify vegetation, and adapt to environmental conditions. However, many factors can be varied, such as seed mix diversity and composition, the proportion of forbs to grasses, and seeding rate, and the most effective levels of each are not clear. Further, soil amendments, such as biochar, may benefit properties of tilled soils, but have not explored in Palouse Prairie …


Investigation Of Small Mammal Species Richness, Abundance, And Genetic Population Structure On And Around The Eastern Washington University Prairie Restoration Site, Sarah Deshazer Jan 2023

Investigation Of Small Mammal Species Richness, Abundance, And Genetic Population Structure On And Around The Eastern Washington University Prairie Restoration Site, Sarah Deshazer

EWU Masters Thesis Collection

Small mammals are an ecologically important component of every landscape on Earth. They are a food source for higher trophic level animals, disperse plant seed and mycorrhizal fungi spore, engineer the landscape through burrowing and foraging activities, and alter plant community composition through selective predation of seed and grain. Studies have shown that small mammals may help facilitate the transition between successive stages in prairie restoration. Eastern Washington University has dedicated 120 acres of campus land to restoration of native prairie habitat. Small mammals can play both a positive and a negative role in restoration, therefore it is important to …


Digital Energy Platforms Considering Digital Privacy And Security By Design Principles, Umit Cali, Marthe Fogstad Dynge, Ahmed Idries, Sambeet Mishra, Ivanko Dmytro, Naser Hashemipour, Murat Kuzlu, Aleksandra Mileva (Ed.), Steffen Wendzel (Ed.), Virginia Franqueira (Ed.) Jan 2023

Digital Energy Platforms Considering Digital Privacy And Security By Design Principles, Umit Cali, Marthe Fogstad Dynge, Ahmed Idries, Sambeet Mishra, Ivanko Dmytro, Naser Hashemipour, Murat Kuzlu, Aleksandra Mileva (Ed.), Steffen Wendzel (Ed.), Virginia Franqueira (Ed.)

Engineering Technology Faculty Publications

The power system and markets have become increasingly complex, along with efforts to digitalize the energy sector. Accessing flexibility services, in particular, through digital energy platforms, has enabled communication between multiple entities within the energy system and streamlined flexibility market operations. However, digitalizing these vast and complex systems introduces new cybersecurity and privacy concerns, which must be properly addressed during the design of the digital energy platform ecosystems. More specifically, both privacy and cybersecurity measures should be embedded into all phases of the platform design and operation, based on the privacy and security by design principles. In this study, these …


Cybersecurity And Digital Privacy Aspects Of V2x In The Ev Charging Structure, Umit Cali, Murat Kuzlu, Onur Elma, Osman Gazi Gucluturk, Ahmet Kilic, Ferhat Ozgur Catak Jan 2023

Cybersecurity And Digital Privacy Aspects Of V2x In The Ev Charging Structure, Umit Cali, Murat Kuzlu, Onur Elma, Osman Gazi Gucluturk, Ahmet Kilic, Ferhat Ozgur Catak

Engineering Technology Faculty Publications

With the advancement of green energy technology and rising public and political acceptance, electric vehicles (EVs) have grown in popularity. Electric motors, batteries, and charging systems are considered major components of EVs. The electric power infrastructure has been designed to accommodate the needs of EVs, with an emphasis on bidirectional power flow to facilitate power exchange. Furthermore, the communication infrastructure has been enhanced to enable cars to communicate and exchange information with one another, also known as Vehicle-to-Everything (V2X) technology. V2X is positioned to become a bigger and smarter system in the future of transportation, thanks to upcoming digital technologies …


Defending Ai-Based Automatic Modulation Recognition Models Against Adversarial Attacks, Haolin Tang, Ferhat Ozgur Catak, Murat Kuzlu, Evren Catak, Yanxiao Zhao Jan 2023

Defending Ai-Based Automatic Modulation Recognition Models Against Adversarial Attacks, Haolin Tang, Ferhat Ozgur Catak, Murat Kuzlu, Evren Catak, Yanxiao Zhao

Engineering Technology Faculty Publications

Automatic Modulation Recognition (AMR) is one of the critical steps in the signal processing chain of wireless networks, which can significantly improve communication performance. AMR detects the modulation scheme of the received signal without any prior information. Recently, many Artificial Intelligence (AI) based AMR methods have been proposed, inspired by the considerable progress of AI methods in various fields. On the one hand, AI-based AMR methods can outperform traditional methods in terms of accuracy and efficiency. On the other hand, they are susceptible to new types of cyberattacks, such as model poisoning or adversarial attacks. This paper explores the vulnerabilities …


Development Of Sensing And Programming Activities For Engineering Technology Pathways Using A Virtual Arduino Simulation Platform, Murat Kuzlu, Vukica Jovanovic, Otilia Popescu, Salih Sarp Jan 2023

Development Of Sensing And Programming Activities For Engineering Technology Pathways Using A Virtual Arduino Simulation Platform, Murat Kuzlu, Vukica Jovanovic, Otilia Popescu, Salih Sarp

Engineering Technology Faculty Publications

The Arduino platform has long been an efficient tool in teaching electrical engineering technology, electrical engineering, and computer science concepts in schools and universities and introducing new learners to programming and microcontrollers. Numerous Arduino projects are widely available through the open-source community, and they can help students to have hands-on experience in building circuits and programming electronics with a wide variety of topics that can make learning electrical prototyping fun. The educational fields of electrical engineering and electrical engineering technology need continuous updating to keep up with the continuous evolution of the computer system. Although the traditional Arduino platform has …


Integration Of Omnet++ Into A Networking Course In An Electrical Engineering Technology Program, Murat Kuzlu, Brian Emmanuel Tamayo, Salih Sarp, Otilia Popescu, Vukica M. Jovanovic Jan 2023

Integration Of Omnet++ Into A Networking Course In An Electrical Engineering Technology Program, Murat Kuzlu, Brian Emmanuel Tamayo, Salih Sarp, Otilia Popescu, Vukica M. Jovanovic

Engineering Technology Faculty Publications

Networking courses are an integral part of electrical engineering technology programs as the majority of electronics in the modern day are required to communicate with each other. They are also getting more attention in manufacturing engineering technology programs because of the development of emerging technologies in Industry 4.0 arena. From laptops, computers, cellphones, modern day vehicles and smart refrigerators, these devices require a certain level of networking in order to communicate with other devices, whether it be locally, or even across the other side of the world. The objective of networking courses in an electrical engineering program is to demonstrate …


Berriasian–Valanginian Geochronology And Carbon-Isotope Stratigraphy Of The Yellow Cat Member, Cedar Mountain Formation, Eastern Utah, Usa, Robert M. Joeckel, Celina A. Suarez, Noah M. Mclean, Andreas Möller, Gregory A. Ludvigson, Marina B. Suarez, James I. Kirkland, Joseph Andrew, Spencer Kiessling, Garrett A. Hatzell Jan 2023

Berriasian–Valanginian Geochronology And Carbon-Isotope Stratigraphy Of The Yellow Cat Member, Cedar Mountain Formation, Eastern Utah, Usa, Robert M. Joeckel, Celina A. Suarez, Noah M. Mclean, Andreas Möller, Gregory A. Ludvigson, Marina B. Suarez, James I. Kirkland, Joseph Andrew, Spencer Kiessling, Garrett A. Hatzell

Conservation and Survey Division

The Early Cretaceous Yellow Cat Member of the terrestrial Cedar Mountain Formation in Utah, USA. has been interpreted as a “time-rich” unit because of its dinosaur fossils, prominent paleosols, and the results of preliminary chemostratigraphic and geochronologic studies. Herein, we refine prior interpretations with: (1) a new composite C-isotope chemostratigraphic profile from the well-known Utahraptor Ridge dinosaur site, which exhibits δ13C features tentatively interpreted as the Valanginian double-peak carbon isotope excursion (the so-called “Weissert Event”) and some unnamed Berriasian features; and (2) a new cryptotephra zircon eruption age of 135.10 ± 0.30/0.31/0.34 Ma (2σ) derived from the CA-ID-TIMS …


Hydrogeologic Field Trip Of Northeast Nebraska, Sue Olafsen Lackey, Kathleen Cameron, Matt Marxsen Jan 2023

Hydrogeologic Field Trip Of Northeast Nebraska, Sue Olafsen Lackey, Kathleen Cameron, Matt Marxsen

Conservation and Survey Division

No abstract provided.


2023 Nebraska Water Leaders Academy, Mark E. Burbach, Robert Matthew Joeckel Jan 2023

2023 Nebraska Water Leaders Academy, Mark E. Burbach, Robert Matthew Joeckel

Conservation and Survey Division

Eighteen participants completed the 2023 Water Leaders Academy bringing the total number of graduates to 186 since the inception of the program in 2011. Assessments of participants’ transformational leadership skills, champion of innovation skills, water knowledge, engagement with water issues, civic capacity, entrepreneurial leadership behaviors, boundary spanning skills, and curiosity increased significantly over the course of the year, according to both the participants and their raters. Feedback from the participants was highly positive and constructive. Academy planners are addressing participant concerns. Results of the program assessment indicate that the curriculum is meeting the Academy’s objectives. Therefore, only minor changes are …


Telescopic Megafans On The High Plains, Usa Were Signal Buffers In A Major Source-To-Sink System, Jesse T. Korus Dr., Robert Matthew Joeckel Jan 2023

Telescopic Megafans On The High Plains, Usa Were Signal Buffers In A Major Source-To-Sink System, Jesse T. Korus Dr., Robert Matthew Joeckel

Conservation and Survey Division

No abstract provided.


3d Hydrostratigraphic And Hydraulic Conductivity Modeling Using Supervised Machine Learning, T. A. Tilahun, Jesse T. Korus Dr. Jan 2023

3d Hydrostratigraphic And Hydraulic Conductivity Modeling Using Supervised Machine Learning, T. A. Tilahun, Jesse T. Korus Dr.

Conservation and Survey Division

No abstract provided.


Nebraska's Water, Nawaraj Shrestha, Ann Briggs, Aaron R. Young, Robert Matthew Joeckel Jan 2023

Nebraska's Water, Nawaraj Shrestha, Ann Briggs, Aaron R. Young, Robert Matthew Joeckel

Conservation and Survey Division

No abstract provided.


Conservation And Survey Division 2023 Annual Report, R. M. Joeckel, M. M. Waszgis Jan 2023

Conservation And Survey Division 2023 Annual Report, R. M. Joeckel, M. M. Waszgis

Conservation and Survey Division

No abstract provided.


Developing Cost-Effective Specialty Adsorbents To Meet The Emerging Challenges Of Pollutant Removal In Surface Water Systems, Diana Ordonez Jan 2023

Developing Cost-Effective Specialty Adsorbents To Meet The Emerging Challenges Of Pollutant Removal In Surface Water Systems, Diana Ordonez

Electronic Theses and Dissertations, 2020-2023

The production of clean water is emphasized under the United Nations goals for sustainable development (SDGs), enlightening the acute need of developing new sustainable technologies in all disciplines. SDGs have urged all engineers in the 21st century to mitigate pollution of drinking water sources and prevent all receiving waterbodies from the impact of agriculture discharge, wastewater effluent, and stormwater runoff. Current water matrix constituents of concern include traditional pollutants (i.e., total nitrogen and total phosphate), natural organic matters (i.e., total organic carbon (TOC), tannic acid), heavy metals (i.e., copper, calcium), and harmful algae toxins (i.e., microcystin), as well as contaminants …


Fabrication And Optimization Of Nafion As A Protective Membrane For Tin-Based Ph Sensors, Shimrith P. Shylendra, Magdalena Wajrak, Kamal Alameh Jan 2023

Fabrication And Optimization Of Nafion As A Protective Membrane For Tin-Based Ph Sensors, Shimrith P. Shylendra, Magdalena Wajrak, Kamal Alameh

Research outputs 2022 to 2026

In this study, a solid-state modified pH sensor with RF magnetron sputtering technology was developed. The sensor consists of an active electrode consisting of a titanium nitride (TiN) film with a protective membrane of Nafion and a reference glass electrode of Ag/AgCl. The sensitivity of the pH sensor was investigated. Results show a sensor with excellent characteristics: sensitivity of 58.6 mV/pH for pH values from 2 to 12, very short response time of approximately 12 s in neutral pH solutions, and stability of less than 0.9 mV in 10 min duration. Further improvement in the performance of the TiN sensor …


Learning From Traditional Ecological Knowledge: Paralytic Shellfish Toxins In Butter Clams, Jackelyn Garcia Jan 2023

Learning From Traditional Ecological Knowledge: Paralytic Shellfish Toxins In Butter Clams, Jackelyn Garcia

WWU Graduate School Collection

Anthropogenic forcing of marine ecosystems is disproportionately impacting Indigenous food systems and the health of coastal Indigenous communities. With increasing harmful algal events, there is rising concern for access and health of coastal communities who rely on shellfish for commercial, food, subsistence, and ceremonial harvest. In the U.S West Coast, the dinoflagellate Alexandrium spp. may produce paralytic shellfish toxins, which can cause shellfish to become toxic and is of especial concern. While recent research has led to greater awareness of the risks associated with paralytic shellfish toxins (PSTs), the concern for harmful algae is not new. Coastal Indigenous communities have …


Selectivity And Structure Of Chimeric Loop Swaps In Sh2 Domains, Sarah N. Smith Jan 2023

Selectivity And Structure Of Chimeric Loop Swaps In Sh2 Domains, Sarah N. Smith

WWU Graduate School Collection

SH2 (Src Homology 2) domains are protein domains that bind to phosphorylated tyrosine residues within cell signaling cascades. They have been found to play a role in certain cancers and immunological disorders. Despite their importance in cell signaling and medical relevance, the structural basis of the various selectivity classes of SH2 domains is only partially understood. Previous research found that the EF and BG loops of the domains contribute to forming the peptide binding pocket, and thus impact their selectivity. To further understand the role of these loops in selectivity, we engineered chimeric SH2 domains by swapping the EF and …


New Synthetic Methods Based On Silicon-Tethered Nucleophilic Addition Reactions, Alexie W. Clover Jan 2023

New Synthetic Methods Based On Silicon-Tethered Nucleophilic Addition Reactions, Alexie W. Clover

WWU Graduate School Collection

With the recent discovery of an iodine mediated rearrangement of diallylsilanes, we set out to investigate a similar fluorine mediated rearrangement, aimed at introducing a new method for synthesizing organofluorine compounds. Interest in incorporating fluorine into organic molecules has grown significantly in recent years, primarily for medicinal applications. Since certain fluorination methods require the use of mCPBA, a common epoxidizing reagent, control experiments were performed on the reaction of several diallylsilanes with mCPBA, anticipating that a competing epoxidation of the diallylsilanes might occur. It was found that the formation of the hydroxy ester occurred through a regioselective epoxide opening from …


Regio- And Diastereoselective Samarium-Mediated Allylic Sulfone Reductions, Cody Schwans Jan 2023

Regio- And Diastereoselective Samarium-Mediated Allylic Sulfone Reductions, Cody Schwans

WWU Graduate School Collection

A series of allylic sulfones were synthesized containing a stereodirecting group and chelating element and subjected to samarium diiodide reductions in the presence of a proton donor. The resulting products could be obtained with high regioselectivity (no less than 95:5) and high diastereoselectivity (>10:1) that correlated with the size of the stereodirecting group. A mechanism is proposed that includes loss of the sulfone and formation of a chelated organosamarium intermediate followed by intramolecular protonation by a samarium-bound proton source. In this way, both the regioselectivity and absolute stereochemistry of the resulting products are explained.


Tuned Gold Layer Growth Onto Plasmonic Sensing Silver Nanocubes Via Synthetic Control Of Reduction Potentials., Nicolas Hall Jan 2023

Tuned Gold Layer Growth Onto Plasmonic Sensing Silver Nanocubes Via Synthetic Control Of Reduction Potentials., Nicolas Hall

WWU Graduate School Collection

Metallic nanoparticles (mNPs) are commonly employed as sensors and detection tools due to their unique plasmonic properties. Silver NPs exhibit these properties in heightened capacity in comparison to other metals. However, Ag NPs are susceptible to oxidation, degradation over time and are biotoxic. These issues are commonly addressed by creating Ag-alloy NPs or by adding additional layers to Ag NPs. This work improves upon these methods by focusing on the growth of an Au layer onto Ag nanocubes (AgNCs), resulting in a layered Au-Ag NC (Au@AgNC). The resulting morphology of these Au@AgNCs are dependent on the synthetic pathway taken and …


Connections Between Eruption Style And Magmatic Reservoir Evolution: Insights From Augustine Volcano, Alaska, Usa, Mahinaokalani G. Robbins Jan 2023

Connections Between Eruption Style And Magmatic Reservoir Evolution: Insights From Augustine Volcano, Alaska, Usa, Mahinaokalani G. Robbins

WWU Graduate School Collection

At a single volcano, eruptive behavior can change through time as the plumbing system evolves. Augustine Volcano, a frequently active intermediate stratovolcano in the Alaska-Aleutian arc (USA), is an ideal setting to investigate magma reservoir processes due to its frequent modern and Holocene eruption history. Its most recent 2006 CE eruption included mixed effusive and moderately explosive (VEI 3) events and has been studied in detail. Proximal fall deposits from this eruption were generally mixed fine ash to lapilli with variable thickness, but typically ~5 cm on the island (Wallace et al., 2010). The Pre-contact “Tephra M” was deposited by …


Class A Sortases: Structures And Alternative Substrate Binding And Cleavage, Brandon Vogel Jan 2023

Class A Sortases: Structures And Alternative Substrate Binding And Cleavage, Brandon Vogel

WWU Graduate School Collection

Sortases, consisting of classes A-F, are cysteine transpeptidases found in the cell wall of Gram-positive bacteria. They play a crucial role in ligating proteins to the cell wall that are responsible for cell adhesion, immune evasion, host cell invasion, and nutrient acquisition through a transpeptidation reaction. Consequently, they are an attractive therapeutic target. Class A sortases are also utilized in protein engineering applications such as sortase-mediated ligations and sortagging. Despite extensive research in the past two decades, gaps persist in understanding how class A sortases recognize their substrates, primarily due to a lack of structural information on sortases non-covalently bound …


The Race Toward Carbon Neutral Ecotourism: Leveraging Life Cycle Analysis And Natural Climate Solutions For A Community Adventure Event, Ted Tarricone Jan 2023

The Race Toward Carbon Neutral Ecotourism: Leveraging Life Cycle Analysis And Natural Climate Solutions For A Community Adventure Event, Ted Tarricone

WWU Graduate School Collection

Global tourism is an interconnected framework of multiple industries that is influenced by and has impacts on economic, social, and environmental structures. Currently, tourism accounts for roughly 8% of global greenhouse gas emissions, which is expected to grow with industry expansion. To develop a scalable system for ecotourism assessment, emission reduction, and solutions to meet carbon neutrality, a small (n=3894 participants) adventure relay race named Ski to Sea in Bellingham, WA was studied. A life cycle analysis (LCA) conducted on the race showed similar proportional results to other tourism LCAs, where transport made up over 80% of the 325 tonnes …


Contaminants Of Emerging Concern In Puget Sound: Screening, Prioritization, And Estrogenic Mixture Response Assessment, Maya Faber Jan 2023

Contaminants Of Emerging Concern In Puget Sound: Screening, Prioritization, And Estrogenic Mixture Response Assessment, Maya Faber

WWU Graduate School Collection

Contaminants of emerging concern (CECs) are chemicals used in daily life, such as pharmaceuticals, personal hygiene products, steroids, pesticides, and flame retardants. The environmental occurrence and toxicology of CECs are poorly characterized, and they are generally unregulated. Traditional toxicological approaches rely on in vivo methods to test whole organisms for apical endpoints, including survival, reproduction, and growth. This is time-consuming and costly, both financially and in terms of laboratory animal well-being, limiting ecotoxicological data for CECs. To overcome this challenge, we are utilizing alternative approaches, including New Approach Methodologies (NAMs), to perform a screening-level evaluation of CECs present in Puget …


Trophic Transfer Of Metals From Seaweed To Shellfish In An Aquaculture System, Sophia Boyd Jan 2023

Trophic Transfer Of Metals From Seaweed To Shellfish In An Aquaculture System, Sophia Boyd

WWU Graduate School Collection

Seafood, including fish, shellfish, and seaweed, are an important source of nutrients that could meet some of the increasing demand for food globally. In addition to nutrients, chemical contaminants can also be acquired from the environment by primary producers. Seaweeds take up a variety of inorganic and organic contaminants, including metals, that may pose risks to human health. Through trophic transfer, organisms can accumulate elevated levels of contaminants from consuming lower trophic-level organisms. Since particulate organic matter, including seaweed detritus, is a food source for filter-feeding bivalves, contaminants present in seaweed could transfer to shellfish via ingestion. The purpose of …


Using Chemical Zoning In Minerals To Understand Magmatic Processes At Augustine Volcano, Alaska, Sloane Kennedy Jan 2023

Using Chemical Zoning In Minerals To Understand Magmatic Processes At Augustine Volcano, Alaska, Sloane Kennedy

WWU Graduate School Collection

The eruption behavior of a volcano is intrinsically linked to magmatic evolution. Augustine Volcano is an active stratovolcano in the Aleutian Arc (AK, USA), showing stratigraphic evidence that eruptions before 1,800 C.E. were more explosive, producing thick pumice deposits, compared to the six eruptions observed in the last 200 years. Tephra B, an understudied ~400-year-old pumice fall unit, represents the last more explosive style eruption at Augustine - making it ideal for studying how changes in magmatic evolution can result in changes in eruption style. For this thesis, I used textural zoning patterns and chemical variations (major and trace elements) …


A Mixed-Methods Study Of Geoscience Identity, Race/Ethnicity, And Gender In Senior Undergraduate Geoscience Majors, Willa Rowan Jan 2023

A Mixed-Methods Study Of Geoscience Identity, Race/Ethnicity, And Gender In Senior Undergraduate Geoscience Majors, Willa Rowan

WWU Graduate School Collection

I conducted a mixed methods study of geoscience identity in undergraduate students to examine the cultural and social aspects of geoscience degree programs. White students are overrepresented in geoscience, and a priority of anti-racism efforts in the field is listening to the experiences of students who are Black, Indigenous, or people of color (BIPOC) to better inform equity and inclusion goals. Structural racism in geoscience pushes BIPOC students out of the field, and it can be better understood by studying socially constructed aspects of learning such as geoscience identity. This study is the first to measure geoscience identity with a …


U-Pb Zircon Geochronology And Structure Of Regional Blueschist Units In The Easton Metamorphic Suite, Northwest Cascades, Wa, Katherine Lang Jan 2023

U-Pb Zircon Geochronology And Structure Of Regional Blueschist Units In The Easton Metamorphic Suite, Northwest Cascades, Wa, Katherine Lang

WWU Graduate School Collection

The Easton metamorphic suite of the Northwest Cascades Thrust System (NWCS) is a well-preserved subduction accretion complex in Washington State. The regional blueschist units of the Easton metamorphic suite include the Mt. Josephine semi-schist, Darrington Phyllite, and Shuksan greenschist/blueschist and all are interpreted to have accreted after the onset of Jurassic subduction beneath North America. This study uses zircon U-Pb geochronology, structure, and field observations to test the regional correlations between units in the Easton metamorphic suite and address models for the timing of subduction accretion along the North American margin in the Late Jurassic – Early Cretaceous. The results …


Structural And Thermodynamic Studies Of Antibody Binding To Blood Coagulation Factor Viii, Jordan Vaughan Jan 2023

Structural And Thermodynamic Studies Of Antibody Binding To Blood Coagulation Factor Viii, Jordan Vaughan

WWU Graduate School Collection

Blood coagulation factor VIII (FVIII) is a 2332 residue glycoprotein expressed in endothelial cells and plays a significant role in the formation of blood clots. Structurally, FVIII’s domains are organized as A1-A2-B-A3-C1-C2. The absence or deficiency of FVIII in the bloodstream gives rise to Hemophilia A; an X-linked bleeding disorder affecting 1 in 5000 males worldwide. To combat this deficiency, patients undergo FVIII replacement therapy which involves frequent injections of FVIII into the bloodstream in the form of blood, plasma, or protein concentrates. Although effective, this treatment commonly results in the development of anti-FVIII inhibitory antibodies in approximately 20-30% of …