Physical Sciences and Mathematics Commons^™

A Statistical Analysis Of The Population Of Barbel In The River Teme

The Plymouth Student Scientist

The focus of this project is on the population of barbel (Barbus barbus) living in the River Teme, over a number of years with the objective of examining the fish population size specifically investigating any temporal trend in fish population numbers and, if found, with the further aim of examining any covariates that may be causing the trend. In order to answer these questions, two datasets were investigated and rigorously analysed in order to ascertain whether stocks of barbel are in decline and, if so, to further examine which covariates could be contributing to their depletion. A number of statistical …

The Role Of Colony Morphology And Substratum Inclination On The Distribution Of Eunicella Verrucosa On Shallow Reefs, Luke Thompson

The Plymouth Student Scientist

Eunicella verrucosa plays an important role in shallow reefs, where they produce a complex 'sheet tree' morphology that supports a variety of benthic-dwelling organisms. E. verrucosa is considered 'vulnerable' by the IUCN Red List, which validates the importance of understanding the biotic and abiotic factors influencing the species morphology and survival. This study analyses how horizontal and vertical slope inclinations influence colony morphology. A population of 115 E. verrucosa colonies were observed at Plymouth's inner breakwater fort at 8–13.8m in depth. The influence of inclination on morphology was investigated by observing colony height, encrusting branch diameter and branch complexity for …

Zagamiite, Caal2si3.5o11, The Hexagonal High-Pressure Cas Phase With Dominant Si, As A Mineral From Mars, Chi Ma, Oliver Tschauner, John R. Beckett, Eran Greenberg, Vitali B. Prakapenka

Geoscience Faculty Research

Within the Ca-Al-silicate system, dense, layered hexagonal phases occur at high temperatures and pressures between 20 and 23 GPa. They have been observed both in nature and in experiments. In this study, we describe the endmember with a dominant sixfold coordinated Si as a mineral zagamiite (IMA 2015-022a). This new mineral identified in Martian meteorites has a general formula of (Ca,Na)(Al,Fe,Mg)2(Si,Al,□)4O11, thus defining CaAl2Si3.5O11 as a previously unknown endmember of the hexagonal CAS phases. Zagamiite assumes space group P63/mmc with a unit cell of a = 5.403(2) Å, c = 12.77(3) Å, V = 322.9(11) Å3, and Z = 2. …

Computing An Image Of Objects Hiding Behind A Black Hole, Shannon Harding

Honors Program Theses and Projects

Gravitational lensing is the bending of light rays around a black hole. The goal of this project was to produce a computer code that would model light rays coming from a grid of objects set behind a rotating black hole. Using these light rays, we produced an image illustrating how this background of objects would appear to an observer on Earth. This was done by creating a MATLAB code to model the paths of multiple light rays at a time. This code was then used to help check and correct a C++ code that produced an image. Over the semester, …

Cabozantinib Plus Atezolizumab In Previously Untreated Advanced Hepatocellular Carcinoma And Previously Treated Gastric Cancer And Gastroesophageal Junction Adenocarcinoma: Results From Two Expansion Cohorts Of A Multicentre, Open-Label, Phase 1b Trial (Cosmic-021)., Daneng Li, Yohann Loriot, Adam Burgoyne, James Cleary, Armando Santoro, Daniel Lin, Santiago Ponce Aix, Ignacio Garrido-Laguna, Ramu Sudhagoni, Xiang Guo, Svetlana Andrianova, Scott Paulson

Kimmel Cancer Center Faculty Papers

BACKGROUND: Cabozantinib is approved for previously treated advanced hepatocellular carcinoma (aHCC) and has been investigated in gastric cancer (GC) and gastroesophageal junction adenocarcinoma (GEJ). Atezolizumab plus bevacizumab is approved for unresectable or metastatic HCC untreated with prior systemic therapy. We evaluated efficacy and safety of cabozantinib plus atezolizumab in aHCC previously untreated with systemic anticancer therapy or previously treated GC/GEJ.

METHODS: COSMIC-021 (ClinicalTrials.gov, NCT03170960) is an open-label, phase 1b study in solid tumours with a dose-escalation stage followed by tumour-specific expansion cohorts, including aHCC (cohort 14) and GC/GEJ (cohort 15). Eligible patients were aged ≥18 years with measurable locally advanced, …

Difference Of Facial Achromatic Numbers Between Two Triangular Embeddings Of A Graph, Kengo Enami, Yumiko Ohno

Theory and Applications of Graphs

A facial $3$-complete $k$-coloring of a triangulation $G$ on a surface is a vertex $k$-coloring such that every triple of $k$-colors appears on the boundary of some face of $G$. The facial $3$-achromatic number $\psi_3(G)$ of $G$ is the maximum integer $k$ such that $G$ has a facial $3$-complete $k$-coloring. This notion is an expansion of the complete coloring, that is, a proper vertex coloring of a graph such that every pair of colors appears on the ends of some edge.

For two triangulations $G$ and $G'$ on a surface, $\psi_3(G)$ may not be equal to $\psi_3(G')$ even if $G$ …

2023 December 21 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Long Oligodeoxynucleotides: Chemical Synthesis, Isolation Via Catching-By-Polymerization, Verification Via Sequencing, And Gene Expression Demonstration, Yipeng Yin, Reed Arneson, Alexander Apostle, Adikari M.D.N. Eriyagama, Komal Chillar, Emily Burke, Martina Jahfetson, Yinan Yuan, Shiyue Fang

Michigan Tech Publications, Part 2

Long oligodeoxynucleotides (ODNs) are segments of DNAs having over one hundred nucleotides (nt). They are typically assembled using enzymatic methods such as PCR and ligation from shorter 20 to 60 nt ODNs produced by automated de novo chemical synthesis. While these methods have made many projects in areas such as synthetic biology and protein engineering possible, they have various drawbacks. For example, they cannot produce genes and genomes with long repeats and have difficulty to produce sequences containing stable secondary structures. Here, we report a direct de novo chemical synthesis of 400 nt ODNs, and their isolation from the complex …

Reverse Pseudo-Gours: A New Sub-Type Of Folia Observed In The Nerja Cave (Se Spain), Cristina Liñán Baena, Concepción Jiménez De Cisneros, Yolanda Del Rosal, Paolo Forti

International Journal of Speleology

A new sub-type of folia named “reverse pseudo-gour” has been observed and described in the Nerja Cave, southern Spain. It consists of fairly vertical, thin barriers (about 5 mm high and 2 mm thick) that develop on the underside of a sub-horizontal surface (shelfstone) and grow in the opposite direction to normal gours (rimstone dams), generating sinuous shapes. Their mineral composition is essentially calcium carbonate, although globular aggregates composed of clay and phosphate minerals have also been identified. The genesis and evolution of these reverse pseudo-gours occur just at the air-water interface and are controlled by (1) the sub-horizontality of …

Prt543, A Protein Arginine Methyltransferase 5 Inhibitor, In Patients With Advanced Adenoid Cystic Carcinoma: An Open-Label, Phase I Dose-Expansion Study, Renata Ferrarotto, Paul Swiecicki, Dan Zandberg, Robert Baiocchi, Robert Wesolowski, Cristina Rodriguez, Meredith Mckean, Hyunseok Kang, Varun Monga, Rajneesh Nath, Neil Palmisiano, Naveen Babbar, William Sun, Glenn Hanna

Department of Medical Oncology Faculty Papers

OBJECTIVES: Currently, no systemic treatments are approved for patients with recurrent and/or metastatic (R/M) adenoid cystic carcinoma (ACC). PRT543, a protein arginine methyltransferase 5 inhibitor that downregulates NOTCH1 and MYB signalling in tumours, is a potential candidate for R/M ACC treatment. We report the safety, tolerability and preliminary efficacy of PRT543 in a dose-expansion cohort of patients with R/M ACC.

MATERIALS AND METHODS: This phase I multicentre, open-label, sequential-cohort, dose-escalation and dose-expansion study (NCT03886831) enrolled patients with advanced solid tumours and select haematologic malignancies. Dose-escalation study design and results were reported previously. In the dose expansion, patients with R/M ACC …

The Ricci Curvature On Simplicial Complexes, Taiki Yamada

Theory and Applications of Graphs

We define the Ricci curvature on simplicial complexes modifying the definition of the Ricci curvature on graphs, and prove upper and lower bounds of the Ricci curvature. These properties are generalizations of previous studies. Moreover, we obtain an estimate of the eigenvalues of the Laplacian on simplicial complexes by the Ricci curvature.

An Innovative Restoration Mode “Macrophytes–Fishes–Benthons–Birds” Implemented In Aesthetic Plateau Wetlands, Junxing Yang, Xiaoai Wang, Xiaofu Pan, Yuanwe Zhang, Heqi Wu, Anli Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Affected by both increasing human activities and climate change, Yunnan Plateau lakes were faced with threats such as water level decreasing, water-body reducing, and severe pollution. Many indigenous species were endangered or even disappeared. The ecological restorations implemented since 1980s almost all used alien species. As an inevitable result, severe negative impacts from alien species were observed on the Plateau wetland ecosystem and indigenous species. To solve these problems, with the support of relevant projects, an innovative restoration mode mainly with indigenous flag-species “macrophytes – fishes – benthons – birds” was proposed. This innovative mode was implemented respectively in Dianchi …

Editorial

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Scenario Simulation Of “35 Goals” And “50 Vision” For Beautiful China Initiative, Huiyi Zhu, Linsheng Yang, Wei Qi, Erqi Xu, Jiewei Chen, Quansheng Ge

Bulletin of Chinese Academy of Sciences (Chinese Version)

Realizing the Beautiful China Initiative is the general goal of China’s ecological civilization construction in the next 30 years. The overall goal includes two phased goals: “35 goals” and “50 vision”. This study first expounds the understanding of the goal from the aspects of ecosystem elements, structure, process, and function, and then constructs an index system to describe the goal and simulates the “35 goals” and “50 vision” under the trend of climate change, population decline and economic growth. The results show that, by 2035, China will have a population of 1.44 billion (including Hong Kong, Macao, and Taiwan) and …

Ecological Operation In Yangtze River Basin With Yangtze River Simulator, Jun Xia, Zhonghui Lin, Chesheng Zhan, Wenjuan Gao, Yunliang Li, Jing Yao, Sidong Zeng, Renyong Huang, Hongzhu Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Ecological protection and green development in the Yangtze River basin are critical to the ecological construction of a Beautiful China. This study analyzes the current situation and main problems of the water ecology in the Yangtze River basin, and introduces the development of the Yangtze River Simulator, and the design for the ecological operation of the Three Gorges Reservoir, the main river, and the lakes connected to the river. Through the simulation of the main stream water ecology and lake water ecology by the Yangtze River Simulator, the optimization plan for the ecological regulation of the Three Gorges Reservoir was …

Developing Characteristic Resource Plants To Build A Beautiful China, Lei Shi, Zheng'an Liu, Lijun Wang, Qingyan Shu, Meiyu Sun, Wei Duan, Hui Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

It is an important way to solve the contradiction among ecology, production and life in natural protected areas and ecologically fragile region by constructing the three-production integration mode of characteristic resource plants. In order to fully tap and make use of the outstanding characteristics of oil tree peony, wine grape and aromatic plants, this study carried out technology integration of variety screening, planting, harvesting, processing, product research and development, and industrialization demonstration in and around natural protected areas and ecologically fragile region. Through the economic benefits generated, the life of the people in the natural protected areas and ecologically fragile …

Stereotactic Mr-Guided On-Table Adaptive Radiation Therapy (Smart) For Borderline Resectable And Locally Advanced Pancreatic Cancer: A Multi-Center, Open-Label Phase 2 Study, Michael Chuong, Percy Lee, Daniel Low, Joshua Kim, Kathryn Mittauer, Michael Bassetti, Carri Glide-Hurst, Ann Raldow, Yingli Yang, Lorraine Portelance, Kyle Padgett, Bassem Zaki, Rongxiao Zhang, Hyun Kim, Lauren Henke, Alex Price, Joseph Mancias, Christopher Williams, John Ng, Ryan Pennell, M Raphael Pfeffer, Daphne Levin, Adam Mueller, Karen Mooney, Patrick Kelly, Amish Shah, Luca Boldrini, Lorenzo Placidi, Martin Fuss, Parag Jitendra Parikh

Department of Radiation Oncology Faculty Papers

BACKGROUND AND PURPOSE: Radiation dose escalation may improve local control (LC) and overall survival (OS) in select pancreatic ductal adenocarcinoma (PDAC) patients. We prospectively evaluated the safety and efficacy of ablative stereotactic magnetic resonance (MR)-guided adaptive radiation therapy (SMART) for borderline resectable (BRPC) and locally advanced pancreas cancer (LAPC). The primary endpoint of acute grade ≥ 3 gastrointestinal (GI) toxicity definitely related to SMART was previously published with median follow-up (FU) 8.8 months from SMART. We now present more mature outcomes including OS and late toxicity.

MATERIALS AND METHODS: This prospective, multi-center, single-arm open-label phase 2 trial (NCT03621644) enrolled 136 …

Synergism Utilization Of Urban Multi-Source Solid Waste And District Green Recycling Development—Taking Dongguan Haixinsha National Resource Recycling Demonstration Base As An Example, Yao Shi, Huiquan Li, Shaohua Chen, Weiqiang Chen, Caihong Xiong, Songgeng Li, Yin Wang, Peng Qian, Shuangde Li, Chao Hua, Ping Lu, Yupeng Liu, Chenmu Zhang, Jianwen Chu, Xin Lu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The long-term storage and extensive disposal of solid waste have caused serious water soil air composite pollution. It is necessary to strengthen the scientific and effective utilization of solid waste, which is not only conducive to solving the major pollution problem of solid waste, but also alleviates the shortage of resources and energy in China. This study summarizes three typical types of urban solid waste comprehensive treatment experience models, and points out that the solid waste circular economy model characterized by centralization, resource utilization, and greening is the main way to solve the complex problem of solid waste. Therefore, it …

Develop Sciences And Technologies To Support The Building Of A Beautiful China In All Respects—Preface On Special Issue “Efforts From Science And Technology To Promote The Building Of A Beautiful China In All Respects”, Quansheng Ge

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Opportunities And Challenges In Monitoring Cultivated Land Red Line In Big Data Era, Jinwei Dong, Yifeng Cui, Yuanyuan Di, Xuan Gao, Xi Chen, Linsheng Yang, Yumei Cai, Jia Ning, Jiyuan Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The demographic reality of a large population and limited land resources in China necessitates the implementation of the world’s most stringent cultivated land protection system. Effective, timely, and accurate monitoring of the status of cultivated land protection red line is essential to ensuring cultivated land protection and food security. The development of cutting-edge technologies such as remote sensing big data, cloud computing, and artificial intelligence has provided new opportunities for cultivated land control and monitoring. This article systematically elaborates on the current research status and challenges in the field of cultivated land protection redline control and monitoring, including the establishment …

Progress And Prospects On Institutional System Construction Of Ecological Civilization In China, Linsheng Yang, Yanan Guo, Huiyi Zhu, Gaodi Xie, Xiaoyong Liao, Quansheng Ge

Bulletin of Chinese Academy of Sciences (Chinese Version)

Since the 18th National Congress of the Communist Party of China, the construction of Ecological Civilization (EC) in China has undergone historic, transitional, and comprehensive changes from theory to practice. The construction of system is the core content and the basic guarantee for the success of EC construction. Based on the government documents of EC construction and related research literatures, this study analyzes the formation and evolution characteristics of China’s EC construction system, parses the development process of representative innovation policies, and then predicts the trend of the further deepening reform of EC system. The results show that the relevant …

Synthetical Solution Of Disaster Risk Reduction And Green Development: A Novel Mode Promoting High-Quality Development In Mountain Areas Of China, Ming Li, Qin Liu, Yukuan Wang, Peng Cui, Xing Gao, Baofeng Di, Jinfeng Liu, Shengwen Qi, Rong Chen, Chunping Tan, Mengzhen Xu, Hao Sun, Jianqiang Zhang, Jiangang Chen, Qiang Zou

Bulletin of Chinese Academy of Sciences (Chinese Version)

China is a mountainous country, with hills, mountains, and plateaus cover about two-thirds of its total land area. The vast area, huge population, rich natural resources, and great potential of development in mountain areas make them the most important “rear garden” supporting the sustainable development of the whole country. Nevertheless, China’s mountain areas are also prone to various kinds of natural disasters, and thus formed a scenario of high overlap between the high-risk zone of natural disasters and the lagging zone of social and economic development. And such scenario has caused significant waste of various related inputs, and becoming a …

Innovation And Practice On Biodiversity Conservation In Sanjiangyuan National Park, Xinquan Zhao, Shixiao Xu, Liang Zhao, Tongzuo Zhang, Linyong Hu, Qi Li, Tongqing Guo

Bulletin of Chinese Academy of Sciences (Chinese Version)

Sanjiangyuan National Park, is one of the first batch of national parks in China, and serves as the largest national park in China. As an important ecological security barrier and a alpine biological germplasm resource base, it has significant conservation value in China and even in the world. Lots of protocols have been taken aiming at ecological tacking protection issues including loss of biodiversity and wildlife habitats, degradation of alpine grassland and overgrazing in Sanjiangyuan National Park. It promotes the implementation of major ecological restoration projects, and has formed the Sanjiangyuan National Park Biodiversity Conservation and Ecological Protection Program with …

Conception On Asian Elephant Ecological Corridor Planning With Implications For Conservation, Xueyou Li, Qiupeng Yu, Zhechang Hu, Xuelong Jiang

Bulletin of Chinese Academy of Sciences (Chinese Version)

In order to practice the concept of coordinated development of “Lucid Waters and Lush Mountains are Invaluable Assets” and “mountains, rivers, forests, farmlands, lakes, grasslands and deserts are part of the community of life”, this study takes “pursuing green development and promoting harmony between humanity and nature” proposed in the report of the 20th National Congress of the Communist Party of China as the theoretical guidance. With the goal of enhancing ecosystem integrity and connectivity, enhancing population communication, enhancing population viability, and providing a model for the construction of ecological corridors for flagship species, based on the current distribution and …

Atmospheric 14Co2 Observation: A Novel Method To Evaluate Carbon Emissions, Zhenchuan Niu, Peng Wang, Shugang Wu, Weijian Zhou

Bulletin of Chinese Academy of Sciences (Chinese Version)

As an important carbon emitter, China faces the stress of carbon peaking and carbon neutrality goals and international carbon reduction duty. The accurate data of carbon emissions are important to evaluate the carbon peaking and carbon neutrality goals and fulfill the international duty of carbon reduction. The Intergovernmental Panel on Climate Change (IPCC) report recommends the combination of top-down atmospheric CO₂ observation with atmospheric inversion to verify the bottom-up inventory of carbon emissions, and the atmospheric ¹⁴CO₂ observation can make the verification more accurate. Radiocarbon (14C) is the most precise tracer of fossil fuel CO₂ and …

Challenges And Countermeasures For Treatment And Remediation Of Contaminated Mega-Sites In China, Xiaoyong Liao, Yixuan Hou, You Li, Tianyi Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The treatment and remediation of pollution at contaminated mega-sites poses a significant challenge in the environmental science both domestically and internationally. Contaminated mega-sites are characterized by their widespread impact, multiple types of pollutants, and significant ecological and environmental threats. The environmental behavior cognition and efficient remediation at contaminated mega-sites face enormous challenges, among which key technological issues such as the formation mechanism of soil and groundwater pollution, accurate identification of pollution sources, and intelligent decision-making optimization urgently need to be solved. In China, contaminated mega-sites are concentrated in economically developed regions such as Beijing-Tianjin-Hebei, the Yangtze River Economic Belt, and …

Effectiveness And Challenges Of Aquatic Ecological Restoration Of Chishui River In Upper Yangtze River, Fei Liu, Huanzhang Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

“To set an example of green development and strength ecological environmental protection in the Chishui River basin” is an important proposal listed in the Outline of the 14th Five-Year Plan (2021--2025) for National Economic and Social Development and Vision 2035 of the People’s Republic of China. Strengthening eco-environmental protection in the Chishui River will play an exemplary and leading role in maintaining fish diversity of the upper Yangtze River, promoting regional high-quality development, and creating a new situation of ecological civilization and Beautiful China. This study interprets the ecological functions of the Chishui River in the upper Yangtze River, expounds …

Impacts, Contributing Factors And Countermeasures Of Extreme Droughts In Poyang Lake, Qi Zhang, Chenyang Xue, Jun Xia

Bulletin of Chinese Academy of Sciences (Chinese Version)

In the past 20 years, the hydrological regime of Poyang Lake changed significantly. The lake water level has been continuously decreasing, resulting in severe droughts. In particular, an extreme drought occurred in 2022, when the lake area shrank to less than 300 km2. The 2022 extreme drought in Poyang Lake had great impacts on economy, society and ecological environment, which aroused great attentions and wide concerns. Based on long-term data series of meteorological and hydrological data and the existing research outcomes and with the aid of hydrological modeling, this study analyzed the impacts and contributing factors of the 2022 drought …

Ten Problems And Solutions For Restoration Of Karst Ecosystem In Southwest China, Xiaoyong Bai, Sirui Zhang, Chen Ran, Luhua Wu, Chaochao Du, Lei Dai, Xingyi Yang, Zilin Li, Yingying Xue, Mingkang Long, Minghui Li, Shu Yang, Qing Luo, Xiaoyun Zhang, Xiaoqian Shen, Fei Chen, Qin Li, Yuanhong Deng, Zeyin Hu, Chaojun Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

The karst areas in southwest China are one of the key but difficult areas targeted in the “Beautiful China” construction initiative, which focuses on soil erosion, proportion of farmland, water pollution, karst drought, ecological restoration, carbon sink, ecological effects of urbanization, rocky desertification management indicators, and biodiversity and sustainability assessment. The study synthesizes the knowledge accumulated during ecological restoration practice in karst areas into 10 problems and solutions that are strong, universal and empirically supported. These problems and solutions help to explain the challenges of achieving sustainability in karst ecology restoration and thus point to solutions. They constitute a core …

Control Of Invasive Plant Spartina Alterniflora: Concept, Technology And Practice, Baohua Xie, Guangxuan Han

Bulletin of Chinese Academy of Sciences (Chinese Version)

Alien Species Spartina alterniflora occupy the living space of native animals and plants, and lead to the reduction of biodiversity in the intertidal zone and wetland ecological service functions. Therefore, it is urgent to curb the rapid expansion of S. alterniflora in China’s coastal areas. This paper introduced the invasion situation and main ecological hazards of S. alterniflora in China, as well as put forward the concept of S. alterniflora control of “hazard assessment – zoning control – monitoring and early warning”. We summarized the control technologies of S. alterniflora at home and abroad and the current situation of S. …