Social and Behavioral Sciences Commons^™

Alterations In 5-Ht2a Receptor Binding In Various Brain Regions Among 6-Hydroxydopamine-Induced Parkinsonian Rats, Yun Li, Xu-Feng Huang, Chao Deng, Barbara J. Meyer, Aimin Wu, Yinghua Yu, Weihai Ying, Guo-Yuan Yang, Midori Yenari, Qing Wang

Faculty of Health and Behavioural Sciences - Papers (Archive)

The serotonergic system has close interactions with the dopaminergic system and is strongly implicated in the pathophysiological mechanisms and therapeutic paradigms of Parkinson’s disease (PD). This study aims to investigate regional changes in 5-hydroxytryptamine (5-HT) 2A receptors in the rat brain 3 weeks after unilateral medial forebrain bundle lesion by 6-hydroxydopamine (6-OHDA). 5-HT 2A receptor distributions and alterations in the postmortem rat brain were detected by [3H]ketanserin-binding autoradiography. In the 6-OHDA-induced Parkinson’s rat model, nigrostriatal dopaminergic neuron loss significantly mediated the decreased [3H]ketanserin binding, predominantly in the agranular insular cortex (17.3%, P 5 0.03), cingulate cortex (18.2%, P < 0.001), prefrontal cortex (8%, P 5 0.043), primary somatosensory cortex (17.7%, P 5 0.002), and caudate putamen (14.5%, P 5 0.02) compared to controls while a profound reduction of tyrosine hydroxylase (TH) immunostaining in the striatum was also observed. Alterations in [3H]ketanserin binding in the examined brain areas may represent the specific regions that mediate cognitive dysfunctions via the serotonin system. The downregulation of 5-HT2A receptor binding in this study also provides indirect evidence for plasticity in the serotonergic system in the rat brains. This study contributes to a better understanding of the critical roles of 5-HT2A receptors in treating neurodegenerative disorders and implicates 5-HT2A receptors as a novel therapeutic target in the treatment of PD.

Is Bra Discomfort A Barrier To Exercise For Breast Cancer Patients?, Sheridan A. Gho, Julie R. Steele, Bridget J. Munro

Faculty of Health and Behavioural Sciences - Papers (Archive)

Goals of work Although exercise can provide a range of benefits for women living with a breast cancer diagnosis, many impediments to exercise exist. Several psychosocial and physical capacity impediments to exercise have been investigated, but no study has systematically investigated whether bras impede breast cancer patients from exercising. This study aimed to assess the extent to which exerciseinduced breast pain and bra discomfort were reported by women living with breast cancer and whether this breast pain and bra discomfort impeded these women from participating in physical activity. Patients and methods Seventy-four women living with a breast cancer diagnosis completed …

Developing Pandemic Communication Strategies: Preparation Without Panic, Sandra C. Jones, Louise Waters, Omnia Holland, John Bevins, Donald C. Iverson

Faculty of Health and Behavioural Sciences - Papers (Archive)

Communication in the media regarding a potential avian influenza epidemic can serve to accurately and effectively inform the public OR misinform and contribute to unnecessary public panic and subsequent undesirable responses. Governments have time to develop communication strategies and specific messages that can effectively convey desired information at different stages of the anticipated pandemic. Effective social marketing incorporates the concepts of formative research, audience segmentation, and consumer focus. Based on the findings from earlier research on public awareness and understanding of bird flu, the collaborators of the project developed evidence-based advertising messages for two primary time-points in pandemic preparation and …

Energy Expenditure Does Not Differ, But Protein Oxidation Rates Appear Lower In Meals Containing Predominantly Meat Versus Soy Sources Of Protein, Sze Yen Tan, Marijka Batterham, Linda C. Tapsell

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background: High protein meals produce 3 relevant effects in weight management: i) higher thermogenic cost, ii) enhanced fat oxidation, and iii) greater satiation. Pork has been reported to be more thermogenic than soy, suggesting meat protein may be superior to plant protein in a high-protein weight loss diet context. In this study, we aimed to compare the effects of high-protein meals using meat, dairy, and soy sources respectively.

Methods: This crossover feeding trial measured energy expenditure, substrate oxidation, and satiety levels of 12 adults during 8-hour stays in a whole-room calorimeter. The 3 isoenergetic high-protein test meals (30% protein, 40% …

The Role Of Histaminergic H1 And H3 Receptors In Food Intake: A Mechanism For Atypical Antipsychotic-Induced Weight Gain?, Chao Deng, Katrina Western-Green, Xu-Feng Huang

Faculty of Health and Behavioural Sciences - Papers (Archive)

Atypical antipsychotics such as olanzapine and clozapine are effective at treating the multiple domains of schizophrenia, with a lowrisk of extra-pyramidal side-effects. However amajor downfall to their use is metabolicside-effects particularly weight gain/obesity,which occurs by unknownmechanisms. The present paper explores the potential candidature of histaminergic neurotransmission in the mechanisms of atypical antipsychoticinduced weight gain, with a focus on the histaminergic H1 and H3 receptors. Olanzapine and clozapine have a high affinity for the H1 receptor, andmeta-analyses showa strong correlation between risk ofweight gain andH1 receptor affinity. In addition, olanzapine treatment decreases H1 receptor binding and mRNA expression in the rat …

Membrane Fatty Acid Composition Of Rat Skeletal Muscle Is Most Responsive To The Balance Of Dietary N-3 And N-6 Pufa, Sarah K. Abbott, P. L. Else, A. Hulbert

Faculty of Health and Behavioural Sciences - Papers (Archive)

The present study quantifies the relationships between diet fatty acid profile and fatty acid composition of rat skeletal muscle phospholipids. Young adult male Sprague–Dawley rats were fed, for 8 weeks, on one of twelve moderate-fat diets (25 % of total energy) differing only in fatty acid profile. SFA content ranged from 8–88 % of total fatty acids, MUFA 6–65 %, total PUFA 4–81 %, n-6 PUFA 3–70 % and n-3 PUFA 1–70 %. Diet PUFA included only essential fatty acids 18 : 2n-6 and 18 : 3n-3. The balance between n-3 and n …

The Time Course Of Configural Change Detection For Novel 3-D Objects, Simone Favelle, Stephen Palmisano

Faculty of Health and Behavioural Sciences - Papers (Archive)

The present study investigated the time course of visual information processing that is responsible for successful object change detection involving the configuration and shape of 3-D novel object parts. Using a one-shot change detection task, we manipulated stimulus and interstimulus mask durations (40–500 msec). Experiments 1A and 1B showed no change detection advantage for configuration at very short (40-msec) stimulus durations, but the configural advantage did emerge with durations between 80 and 160 msec. In Experiment 2, we showed that, at shorter stimulus durations, the number of parts changing was the best predictor of change detection performance. Finally, in Experiment …

Effects Of Simvastatin And 6-Hydroxydopamine On Histaminergic H1 Receptor Binding Density In Rat Brains, Chang-Hua Hu, Chao Deng, Nikolce Mackovski, Ling Long, Cansheng Zhu, Yu Yang, Yuge Wang, J-Z Chen, Xu-Feng Huang, Qing Wang

Faculty of Health and Behavioural Sciences - Papers (Archive)

Statins have been widely used for the treatment of a variety of medical conditions including psychoneurological disorders beyond their original use in lowering cholesterol. Histamine receptors play an important role in the regulation of neural activity, however, it is unknown whether statins act on histamine receptors, particularly for their neural regulatory effects. This study examined the effects of simvastatin and 6-hydroxydopamine (6-OHDA) lesions on histamine H1 receptors using [3H] pyrilamine binding autoradiography. Compared to the saline group, simvastatin (1 mg/kg/day) significantly decreased H1 receptor bindings in the primary motor cortex (M1), ventromedial hypothalamic nucleus (VMH), caudate putamen (CPu), accumbens core …

Direct To Consumer Advertising Versus Disease Awareness Advertising: Consumer Perspectives From Down Under, Danika Hall, Sandra C. Jones, J. Hoek

Faculty of Health and Behavioural Sciences - Papers (Archive)

At present, only the United States and New Zealand allow direct-to-consumer advertising (DTCA) of prescription medicine. In other countries where DTCA is not allowed, including Australia and the United Kingdom, pharmaceutical companies undertake disease awareness advertising (DAA). In DAA, advertisements do not name a drug directly, but provide general information about diseases and treatments, and encourage consumers to talk to their doctor. Similar debate surrounds these two forms of advertising, yet while past research has explored consumers' attitudes and behaviour in response to DTCA, little consideration has been given to DAA. This paper compares Australian consumers' perceptions of DAA with …

Australians Love To Drive: What Do Drivers Over 55 Say About Dementia And Driving?, Victoria Traynor, Catherine Andrew, Jo-Ann Brown

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background: Driving requires cognitive skills that can be compromised by dementia and some drivers find it difficult accepting the need to consider retirement from driving. This workshop explores driving and dementia and provides opportunities to discuss this topic with consumers, carers, practitioners and researchers.

A Philology Of Liberation: Dr. Martin Luther King, Jr. As A Reader Of The Classics, Thomas Strunk Ph.D.

Verbum Incarnatum: An Academic Journal of Social Justice

This paper explores the intellectual relationship between Dr. Martin Luther King, Jr. and the classics, particularly the works of Plato, Sophocles, and Aeschylus. Recognizing Dr. King as a reader of the classics is significant for two reasons: the classics played a formative role in Dr. King’s development into a political activist and an intellectual of the first order; moreover, Dr. King shows us the way to read the classics. Dr. King did not read the classics in a pedantic or even academic manner, but for the purpose of liberation. Dr. King’s legacy, thus, is not merely his political accomplishments but …

Membrane Fatty Acid Composition And Longevity Of Mammals And Birds, Anthony J. Hulbert, Magdalene Trzcionka, William A. Buttemer

Faculty of Science, Medicine and Health - Papers: part A

The fatty acid composition of membrane lipids varies systematically among species in a manner that is consistent with their metabolic rate and longevity. Because the susceptibility of fatty acids to peroxidation relates directly to their extent of unsaturation, it is possible to calculate a peroxidation index (PI) for membranes through characterization of their specific fatty acid composition. Long-living mammals and birds have membrane lipids with a lower PI than shorter-living species. Bird and mammal species with the same maximum life span also have membrane lipids with essentially the same PI. Exceptionally long-living mammals and birds usually have membrane lipids high …

Barriers To Hiv Couples Testing: The African American Woman's Perspective, Frederick Scott Smith

Theses Digitization Project

African American Women continue to contract HIV/AIDS at an alarming rate. Of all the women living with Aids in the United States, 64% were African American and two out of three African American women got HIV from having unprotected sex with a man. The purposes of the study are to identify perceived barriers to HIV testing of the intimate partners of African American Women and subsequently identify an effective couples of HIV testing strategy. The research study investigated the primary causes for low HIV testing rates of African American couples. This study uttilized a quantitatve method using self-administered questionaires. The …

Correlates Of Weight Concern And Control In A Hispanic College Student Sample., J. Blow, T. Taylor, Theodore V. Cooper, C. K. Redfearn

Theodore V. Cooper

No abstract provided.

Safe Medication Use Among Hispanic College Students: Knowledge, Attitudes And Behaviors, Tania Guadalupe Quiroz

Open Access Theses & Dissertations

College students are at increased risk of medication errors. Research suggests that young adults are active users of over-the- counter (OTC) medications and other products that may increase the risk for negative health outcomes. Therefore, it is very important to analyze young adults' attitudes, beliefs, and behaviors about medication use among college students in order to provide them with the necessary information. Due to language and cultural factors, the issue is particularly relevant in U.S.-Mexico border communities. This casual-comparative study examined knowledge, attitudes, and behaviors regarding medication use among Hispanic college students. Data was collected through a survey developed by …

Glycemic Index And Pregnancy: A Systematic Literature Review, Jimmy Chun Yu Louie, Jennie C. Brand-Miller, Tania P. Markovic, Glynis P. Ross, Robert G. Moses

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background/Aim. Dietary glycemic index (GI) has received considerable research interest over the past 25 years although its application to pregnancy outcomes is more recent. This paper critically evaluates the current evidence regarding the effect of dietary GI on maternal and fetal nutrition. Methods. A systematic literature search using MEDLINE, EMBASE, CINAHL, Cochrane Library, SCOPUS, and ISI Web of Science, from 1980 through September 2010, was conducted. Results. Eight studies were included in the systematic review. Two interventional studies suggest that a low-GI diet can reduce the risk of large-for-gestational-age (LGA) infants in healthy pregnancies, but one epidemiological study reported an …

The Diet That Works, Yasmine Probst, Rebecca L. Thorne

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

Marketing To Children And Teens On Australian Food Company Web Sites, Amanda Reid, Sandra C. Jones

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

Comparison Of Multiple And Novel Measures Of Dietary Glycemic Carbohydrate With Insulin Resistant Status In Older Women, Therese O'Sullivan, Alexandra P. Bremner, Sheila O'Neill, Philippa M. Lyons-Wall

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background: Previous epidemiological investigations of associations between dietary glycemic intake and insulin resistance have used average daily measures of glycemic index (GI) and glycemic load (GL). We explored multiple and novel measures of dietary glycemic intake to determine which was most predictive of an association with insulin resistance. Methods: Usual dietary intakes were assessed by diet history interview in women aged 42-81 years participating in the Longitudinal Assessment of Ageing in Women. Daily measures of dietary glycemic intake (n = 329) were carbohydrate, GI, GL, and GL per megacalorie (GL/Mcal), while meal based measures (n = 200) were breakfast, lunch …

The Polyunsaturated Fatty Acid Intakes Of Children From The Kids Eat Kids Play Survey, N Kolanu, B J. Meyer

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

Nutrition Screening: Time To Address The Skeletons In The Bedroom Closet As Well As Those In Hospitals, Karen E. Charlton

Faculty of Health and Behavioural Sciences - Papers (Archive)

Ever since Dr Charles Butterworth's seminal article in 1974¹ on the widespread prevalence of malnutrition in hospitalised patients and its detrimental effect on recovery, attempts have been made to improve the detection of malnutrition through screening initiatives. However, despite compelling evidence that those who are either malnourished at admission or become malnourished during their hospital stay experience increased surgical complications, greater morbidity and increased length of hospital stay^2,3 as well as higher rates of mortality at 12 months,^4,5 malnutrition often remains undetected and untreated because it is not considered to be a clinical priority. Even overt signs …

Point-Of-Sale Alcohol Promotions In The Perth And Sydney Metropolitan Areas, Sandra C. Jones, Lance R. Barrie

Faculty of Health and Behavioural Sciences - Papers (Archive)

There is considerable evidence that reducing the price of alcohol increases the amount consumed, particularly among young people. However, there is an absence of research on other point-of-sale (POS) alcohol marketing strategies - such as those that ‘reward’ purchasers with free gifts. The purpose of the present study was to document the nature and extent of POS alcohol promotions in bottle shops in two Australian capital cities. An audit tool was developed and point-of-sale promotions were found to be ubiquitous, with 416 promotions identified across 24 audits (an average of 17.3 promotions per outlet; 19.8 in Sydney and 14.9 in …

Long-Term Care For People With Dementia: Environmental Design Guidelines., Richard Fleming, Nitin Purandare

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

Effects Of Simvastatin And 6-Hydroxydopamine Lesion On Histaminergic H1 Receptor Binding In Rat Brains, C H. Hu, C Deng, Xu-Feng Huang, J Chen, Q Wang

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

General Practice Registrars: Attitudes Of Older Patients, Andrew D. Bonney, Sandra C. Jones, Lyn Phillipson, Donald C. Iverson

Faculty of Health and Behavioural Sciences - Papers (Archive)

Previous research indicates that older patients may be less willing to consult general practice registrars (GPRs), reducing training opportunities in chronic/complex care. This survey explores older patients’ attitudes in order to inform models of interaction that would be acceptable to patients. METHODS Ten training general practices distributed questionnaires for self completion to 50 patients aged 60 years and over. Chi-square, Spearman’s rho and logistic regression were used for analysis. RESULTS The response rate was 47%. Ninetysix percent wanted ongoing contact with their general practitioner if they saw a GPR. Twenty-four percent were comfortable with GPR chronic/complex care, increasing to 73% …

Ecstasy (Mdma) And Its Relationship With Self Report Depression, Anxiety And Schizotypy, Lisa Woods, Emma Barkus

Faculty of Health and Behavioural Sciences - Papers (Archive)

Abstract. Aims: The relationship between ecstasy and affective psychological symptoms are still subject to debate. We aimed to examine the relationship between Ecstasy use and self-report depression, anxiety and schizotypy. Design: Data were collected via structured remote self-report questionnaires. Participants: Participants were split into three groups: a control group with no ecstasy use, a light ecstasy user group (<50 >times), and a heavy ecstasy user group (>50 times). Measurements: Amount and patterns of ecstasy use were recorded, the Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) measured depression and anxiety respectively, and schizotypal traits were measured using the …

Examining The Social Processes Of 'Innovation' To Inform The Development Of A New Framework For Making Sense Of ''Social Innovation", Patrick M. Dawson, Lisa Daniel

Faculty of Health and Behavioural Sciences - Papers (Archive)

In the face of increasing pressure to change and adapt to the needs of highly competitive business markets, it is not unusual for management to focus on the commercial payback on technical innovations and to downplay social processes. Typically, company survival is explained in terms of an 'innovation imperative' where new products and services are part of the dynamic business environment for securing and maintaining competitive advantage. Historically, the focus has been on how to translate innovations in science and technology into commercial applications. We contend that whilst largely downplayed, social processes have always been essential tounderstanding innovation and that …

Orientation Tuning Of Contrast Masking Caused By Motion Streaks, Deborah Apthorp, John Cass, David Alais

Faculty of Health and Behavioural Sciences - Papers (Archive)

We investigated whether the oriented trails of blur left by fast-moving dots (i.e., “motion streaks”) effectively mask grating targets. Using a classic overlay masking paradigm, we varied mask contrast and target orientation to reveal underlying tuning. Fast-moving Gaussian blob arrays elevated thresholds for detection of static gratings, both monoptically and dichoptically. Monoptic masking at high mask (i.e., streak) contrasts is tuned for orientation and exhibits a similar bandwidth to masking functions obtained with grating stimuli (È30 degrees). Dichoptic masking fails to show reliable orientation-tuned masking, but dichoptic masks at very low contrast produce a narrowly tuned facilitation (È17 degrees). For …

Anisotropies In Judging The Direction Of Moving Natural Scenes, Steven C. Dakin, Deborah Apthorp, David Alais

Faculty of Health and Behavioural Sciences - Papers (Archive)

Although visual systems are optimized to deal with the natural visual environment, our understanding of human motion perception is in large part based on the use of artificial stimuli. Here, we assessed observers’ ability to estimate the direction of translating natural images and fractals by having them adjust the orientation of a subsequently viewed line. A system of interleaved staircases, driven by observers’ direction estimates, ensured that stimuli were presented near one of 16 reference directions. The resulting error distributions (i.e., the differences between reported and true directions) reveal several anisotropies in global motion processing. First, observers’ estimates are biased …

Transition To Work Roles Among Youth In India, International Institute For Population Sciences (Iips), Population Council

Poverty, Gender, and Youth

Looking at the current employment situation of youth in six states in India, this Population Council policy brief argues that significant investment in terms of appropriate policies and programs is required to improve the employability of youth in the country and thereby enable them to find full and productive employment. Concerted efforts to improve the employability of youth and to enhance the reach of existing programs aimed at job creation among youth are most urgently required in states like Bihar, Jharkhand, and Rajasthan. At the same time, efforts to meet the large unmet need for vocational skills training are needed …