Physical Sciences and Mathematics Commons^™

Coreflooding Evaluation Of Fiber-Assisted Recrosslinkable Preformed Particle Gel Using An Open Fracture Model, Shuda Zhao, Ali Al Brahim, Junchen Liu, Baojun Bai, Thomas P. Schuman

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Recrosslinkable Preformed Particle Gels (RPPGs) Have Been Used to Treat the Problem of Void Space Conduits (VSC) and repair the "Short-Circuited" Waterflood in Alaska's West Sak Field. Field Results Showed a 23% Increase in Success Rates over Typical Preformed Particle Gel (PPG) Treatments. in This Paper, We Evaluated Whether Adding Fiber into RPPGs Can Increase the RPPG Plugging Efficiency and Thus Further Improve the Success Rate. We Designed Open Fracture Models to Represent vs.C and Investigated the Effect of Swelling Ratio (SR), Fracture Size, and Fiber Concentration on Gel Injection Pressure, Water Breakthrough Pressure, and Permeability Reduction. Results Show that …

Improving Automatic Melanoma Diagnosis Using Deep Learning-Based Segmentation Of Irregular Networks, Anand K. Nambisan, Akanksha Maurya, Norsang Lama, Thanh Phan, Gehana Patel, Keith Miller, Binita Lama, Jason Hagerty, Ronald Stanley, William V. Stoecker

Chemistry Faculty Research & Creative Works

Deep Learning Has Achieved Significant Success in Malignant Melanoma Diagnosis. These Diagnostic Models Are Undergoing a Transition into Clinical Use. However, with Melanoma Diagnostic Accuracy in the Range of Ninety Percent, a Significant Minority of Melanomas Are Missed by Deep Learning. Many of the Melanomas Missed Have Irregular Pigment Networks Visible using Dermoscopy. This Research Presents an Annotated Irregular Network Database and Develops a Classification Pipeline that Fuses Deep Learning Image-Level Results with Conventional Hand-Crafted Features from Irregular Pigment Networks. We Identified and Annotated 487 Unique Dermoscopic Melanoma Lesions from Images in the ISIC 2019 Dermoscopic Dataset to Create a …

Selectively Modified Lactose And N-Acetyllactosamine Analogs At Three Key Positions To Afford Effective Galectin-3 Ligands †, Shuay Abdullayev, Priyanka Dipak Kadav, Purnima Bandyopadhyay, Francisco Javier Medrano, Gabriel A. Rabinovich, Tarun K. Dam, Antonio Romero, René Roy

Michigan Tech Publications

Galectins constitute a family of galactose-binding lectins overly expressed in the tumor microenvironment as well as in innate and adaptive immune cells, in inflammatory diseases. Lactose ((β-D-galactopyranosyl)-(1→4)-β-D-glucopyranose, Lac) and N-Acetyllactosamine (2-acetamido-2-deoxy-4-O-β-D-galactopyranosyl-D-glucopyranose, LacNAc) have been widely exploited as ligands for a wide range of galectins, sometimes with modest selectivity. Even though several chemical modifications at single positions of the sugar rings have been applied to these ligands, very few examples combined the simultaneous modifications at key positions known to increase both affinity and selectivity. We report herein combined modifications at the anomeric position, C-2, and O-3′ of each of the two …

Inducible Nitric Oxide Synthase Embedded In Alginate/Polyethyleneimine Hydrogel As A New Platform To Explore No-Driven Modulation Of Biological Function, Shaimaa Maher, Lauren A. Smith, Celine A. El-Khoury, Haitham F. Kalil, Khalid Sossey-Alaoui, Mekki Bayachou

Chemistry Faculty Publications

Nitric oxide (NO), a small free radical molecule, turned out to be pervasive in biology and was shown to have a substantial influence on a range of biological activities, including cell growth and apoptosis. This molecule is involved in signaling and affects a number of physiologic functions. In recent decades, several processes related to cancer, such as angiogenesis, programmed cell death, infiltration, cell cycle progression, and metastasis, have been linked with nitric oxide. In addition, other parallel work showed that NO also has the potential to operate as an anti-cancer agent. As a result, it has gained attention in cancer-related …

Organic–Inorganic Manganese (Ii) Halide Hybrid Combining The Two Isomers Cis/Trans Of [Mncl4(H2o)2]: Crystal Structure, Physical Properties, Pharmacokinetics And Biological Evaluation, Mansoura Bourwina, Sandra Walha, Najeh Krayem, Riadh Badraoui, Faten Brahmi, Mark M. Turnbull, Wejdan M. Alshammari, Mejdi Snoussi, Thierry Roisnel, Houcine Naïli

Chemistry

A manganese (II) complex templated by hexahydro-1,4-diazepinediium as a counter ion was grown by slow evaporation from an aqueous solution at room temperature. The X-ray diffraction analysis revealed that the compound (C₅H₁₄N₂)[MnCl₄(H₂O)₂] crystallizes in the centrosymmetric space group P2/c of the monoclinic system. The crystal structure of the Mn(II) complex is characterized by an alternation of 0-dimensional organic and inorganic stacks linked together by N/O-H…Cl and N-H…O hydrogen bonds, which lead to a three-dimensional supramolecular architecture. In this structure, the inorganic layer is built up by independent anionic …

Nanoscale Imaging Of Electrocatalytic Nanomaterials By High-Resolution Scanning Electrochemical Microscopy, Xiang Wang

Dissertations, Theses, and Capstone Projects

Numerous insights of the structure–electrochemical activity relationship of nanocatalysts have been obtained by using macroscopic electrochemical measurements over the last several decades. However, signals measured by large electrodes are inevitably averaged out of many nanocatalysts, non-uniformed sizes, uneven morphologies, and multiple crystallographic facets. Over the last ten years, Scanning Electrochemical Microscopy (SECM) has advanced electrochemical measurements toward micro- to nanoscale level at a high spatial resolution. The advantages of using nanoelectrode in SECM include fast mass transfer of reactive species, dominated radial diffusion pattern, small double layer capacitance and small RC constant. In this thesis, high-resolution SECM is applied to …

Optimized Peptide Nanomaterials As Delivery Vehicles For Hydrophobic Metal-Based Anticancer Agents, Yaron Marciano

Dissertations, Theses, and Capstone Projects

Enzyme-responsive materials have been well explored, particularly as therapeutic and diagnostic agents. In this thesis we demonstrate that anionic self-assembling peptides can be utilized as delivery vehicles for metal-based hydrophobic payloads. The tunability of the system is highlighted as well as the increase in cytotoxicity and selectivity in vitro. The rapid degradation of peptides in cell media may lead to the formation of new peptide-drug bioconjugates with increased activity and selectivity. The physiological stability of these peptide delivery vehicles has been optimized by capping the N-terminus with an acetyl group. This simple backbone modification was shown to not prevent self-assembly, …

Synthesis And Biomedical Applications Of Hollow Iron Oxide Nanoparticles, Aloka S. Paragoda Arachchilage

Dissertations, Theses, and Capstone Projects

Nano-scale materials have gained much attention during the past few decades due to the stark differences in their properties compared to bulk material. Thus, they are being studied for a myriad of applications ranging from harnessing solar energy to diagnostics. This thesis focuses on the synthesis of hollow iron oxide nanoparticles using Galvanic replacement reactions and their application in drug delivery. Moreover, the use of a peptide precursor for the enhancement of exosomes is also discussed.

Chapter 1 discusses a simple and economical Galvanic approach used for the synthesis of hollow one-dimensional iron oxide nanotubes. In the initial reaction, the …

Synthesis And Analysis Of Novel Troponoid-Based Chemical Probes, Alex Berkowitz

Dissertations, Theses, and Capstone Projects

Troponoids are a class of non-benzenoid aromatic species featuring a cycloheptatrienone ring and varying degrees of oxygenation. These scaffolds have proven ubiquitous amongst natural products, and have displayed promise as therapeutic agents against a variety of diseases. Herein, we will describe our efforts towards furthering troponoids as potential pharmaceuticals. In Chapter 1, we outline a kojic acid-derived oxidopyrylium cycloaddition/ring-opening method developed in our lab to generate ahydroxytropolones (aHTs). This route was successfully adapted to synthesize a small library of lipophilic aHTs that were proven to be effective against herpes simplex virus-1 (HSV-1) replication, while providing further insight into the mechanism …

H-Conise2/Nc Dodecahedral Hollow Structures For High-Performance Supercapacitors, P. Salehan, Ali A. Ensafi, Z. Andikaey, B. Rezaei

Chemistry & Biochemistry Faculty Publications and Presentations

The synergistic effect between metal ions and increasing the surface area leads to the fabrication of supercapacitor materials with high capacities. It is predicted that transition metal selenide compounds will be ideal electrode materials for supercapacitors. However, the defects of poor conductivity and volume expansion of the compounds are fundamental problems that must be solved. In this work, we successfully synthesized the cobalt–nickel selenide nitrogen-doped carbon (H-CoNiSe₂/NC) hollow polyhedral composite structure using ZIF-67 as a precursor. The CoSe₂ and NiSe₂ nanoparticles embedded in the NC polyhedral framework offer a wealth of active sites for the whole …

Diverse Secondary Metabolites Are Expressed In Particle-Associated And Free-Living Microorganisms Of The Permanently Anoxic Cariaco Basin, David Gellar-Mcgrath, Paraskevi Mara, Gordon T. Taylor, Elizabeth A. Suter, Virginia Edgcomb, Maria Pachiadaki

Faculty Works: BCES (1999-2023)

Secondary metabolites play essential roles in ecological interactions and nutrient acquisition, and are of interest for their potential uses in medicine and biotechnology. Genome mining for biosynthetic gene clusters (BGCs) can be used for the discovery of new compounds. Here, we use metagenomics and metatranscriptomics to analyze BGCs in free-living and particle-associated microbial communities through the stratified water column of the Cariaco Basin, Venezuela. We recovered 565 bacterial and archaeal metagenome-assembled genomes (MAGs) and identified 1154 diverse BGCs. We show that differences in water redox potential and microbial lifestyle (particle-associated vs. free-living) are associated with variations in the predicted composition …

Engineered Plga Nanofibers For Drug Delivery, Andrew Mancuso

Dissertations, Theses, and Capstone Projects

Poly-lactic-co-glycolic acid (PLGA) polymers are rapidly gaining momentum as a platform for next-generation drug delivery systems due to their ease and low cost of synthesis, favorable biocompatibility and biodegradability, and lack of toxicity. In particular, the application of drug-loaded PLGA nanofibers directly to a target tissue may represent a promising alternative to traditional routes of drug administration (e.g., oral, injectable) as they offer the potential to greatly improve bioavailability, increase efficacy, and reduce off-target toxicity. Furthermore, the use of such a system may potentially allow for greater flexibility in clinical drug development, by enabling the use of compounds which have …

Ultra-Fast Bioorthogonal Spin-Labeling And Distance Measurements In Mammalian Cells Using Small, Genetically Encoded Tetrazine Amino Acids, Subhashis Jana, Eric G. B. Evans, Hyo Sang Jang, Shuyang Zhang, Hui Zhang, Andrzej Rajca, Sharona E. Gordon, William N. Zagotta, Stefan Stoll, Ryan A. Mehl

Chemistry Department: Faculty Publications

Studying protein structures and dynamics directly in the cellular environments in which they function is essential to fully understand the molecular mechanisms underlying cellular processes. Site-directed spin-labeling (SDSL)—in combination with double electron–electron resonance (DEER) spectroscopy—has emerged as a powerful technique for determining both the structural states and the conformational equilibria of biomacromolecules. In-cell DEER spectroscopy on proteins in mammalian cells has thus far not been possible due to the notable challenges of spin-labeling in live cells. In-cell SDSL requires exquisite biorthogonality, high labeling reaction rates and low background signal from unreacted residual spin label. While the bioorthogonal reaction must be …

Atomistic Details Of Peptide Reversed-Phase Liquid Chromatography From Molecular Dynamics Simulations, Pablo M Scrosati, Lars Konermann

Chemistry Publications

Peptide separations by reversed-phase liquid chromatography (RPLC) are an integral part of bottom-up proteomics. These separations typically employ C18 columns with water/acetonitrile gradient elution in the presence of formic acid. Despite the widespread use of such workflows, the exact nature of peptide interactions with the stationary and mobile phases are poorly understood. Here we employ microsecond molecular dynamics (MD) simulations to uncover details of peptide RPLC. We examined two tryptic peptides, a hydrophobic and a hydrophilic species, in a slit pore lined with C18 chains that were grafted onto SiO₂ support. Our simulations explored peptide trapping, followed by desorption …

Small Molecule Egfr Inhibitors As Anti-Cancer Agents: Discovery, Mechanisms Of Action, And Opportunities, Tanzida Zubair, Debasish Bandyopadhyay

Chemistry Faculty Publications and Presentations

Epidermal growth factor receptors (EGFRs) are a class of receptor tyrosine kinase that are also called ErbB1 and HER1. EGFR tyrosine kinase activity inhibition is considered a promising therapeutic strategy for the treatment of cancer. Many small-molecule inhibitors of EGFR tyrosine kinase (EGFR-TK), from medicinally privileged molecules to commercial drugs, have been overviewed. Particular attention has been paid to the structure of the molecule and its mechanism of action if reported. Subsequent classification of the molecules under discussion has been carried out. Both natural and synthetic and reversible and irreversible EGFR-tyrosine kinase inhibitors have been discussed. Various types of cancers …

Carbon Dioxide Capture Potential Of Chitosan-Nanocrystalline Cellulose Aerogel Composite Materials: Synthesis, Functionalization, And Characterization, Victor Oghenekohwo

Theses and Dissertations

The carbon dioxide capture technology has been established as an invaluable player in the current global efforts to allay the warming of the planet and climate change. In this connection, the study centers on the valorization of waste organic materials for the application described herein. The sorbents, sourced from a combination of by-products of food processing and agricultural residue waste products, viz. seafood waste and sugarcane bagasse, showed prospects for selective carbon dioxide capture, adsorbing up to 5.78 mg/g of the gas at 273 K and 2.82 mg/g at 298 K, as observed on the Micromeritic ASAP 2020 surface area …

Polyethersulfone Thin-Film Nanocomposite Membrane Embedded With Amine-Functionalized Graphene Oxide For Desalination Applications, Ahmed Bahaeldin

Theses and Dissertations

Thin-film nanocomposite (TFN) desalination membranes were prepared based on a polyethersulfone (PES) support, where the polyamide (PA) layer was embedded with amine-functionalized graphene oxide (GO). The effect of adding various concentrations of functionalized and un-functionalized GO on the desalination performance, hydrophilicity, and morphology of the membranes was additionally assessed throughout this work. Scanning electron microscopy (SEM) measurements were used to assess the morphology of the membranes in combination with Brunauer-Emmett-Teller (BET) analysis. Contact angle measurements were used to gauge the hydrophilicity of the synthesized membranes. The membrane with the best desalination performance contained 1x10^-3 wt/vol% of functionalized GO in …

Synthesis Of Ni(Ii) Complexes For Allylic C(Sp3)-H Bond Activation For Aerobic Oxidation Catalysis, Shagana Kukendran

Electronic Thesis and Dissertation Repository

Nickel is a widely abundant and inexpensive metal. Catalysts are substances that remain unconsumed and increase the rate of reactions by reducing the activation energy barrier, often by providing an alternative route. The main goal of this study is to prepare Ni(II) complexes that can promote a catalytic aerobic oxidation reaction by breaking allylic C-H bonds. Based on previous studies, allylnickel N-heterocyclic carbene complexes react with molecular oxygen to give useful carbonyl compounds with a Ni(II)-OH by-product, which undergoes dimerization. In order to achieve catalysis, dimerization of the Ni(II)-OH should be prevented and C-H activation has to be achieved to …

Geothermal Energy And Its Impacts On The Environment, Aditi Gorthy, Nathan Tran, Laureen Pierre-Louis

Mako: NSU Undergraduate Student Journal

From the multitude of energy sources that we have developed throughout the eons, renewable energy or “clean energy” has been on the rise to combat global warming and climate change which burning nonrenewable sources of energy have contributed to. Before geothermal energy is used as part of the mainstream energy sources some aspects must be analyzed and resolved. Unfortunately, geothermal power plants still release pollutants, such as carbon dioxide and sulfur dioxide, into the environment and cause general environmental disruptions due to drilling and changes in land formations. Recent and future studies have been and should be conducted to find …

Nanoscale Hafnium Metal-Organic Frameworks Enhance Radiotherapeutic Effects By Upregulation Of Type I Interferon And Tlr7 Expression, Eunseo Choi, Madeleine R. Landry, Nathan Pennock, Katherine Weinfurter, Multiple Additional Authors

Chemistry Faculty Publications and Presentations

Recent preclinical and clinical studies have highlighted the improved outcomes of combination radiotherapy and immunotherapy. Concurrently, the development of high-Z metallic nanoparticles as radiation dose enhancers has been explored to widen the therapeutic window of radiotherapy and potentially enhance immune activation. In this study, we evaluate folate-modified hafnium-based metal-organic frameworks (HfMOF-PEG-FA) in combination with imiquimod, a TLR7 agonist, as a well-defined interferon regulatory factor (IRF) stimulator for local antitumor immunotherapy. The enhancement of radiation dose deposition by HfMOF-PEG-FA and subsequent generation of reactive oxygen species (ROS) deregulates cell proliferation and increases apoptosis. HfMOF-PEG-FA loaded with imiquimod (HfMOF-PEG-FA@IMQ) increases DNA double-strand …

Preface To Special Issue: Electrocatalysis And Electrosynthesis (Ⅰ), Fang-Yi Cheng, Shuang-Yin Wang, Tian-Hua Zhou

Journal of Electrochemistry

No abstract provided.

Electrochemical Oxidation Of Ethylene On Palladium Electrode, Wei-Xing Wu, Ying Wang

Journal of Electrochemistry

The electrochemical oxidation of C₂H₄ is attracting increasing attention due to its vast potential market. The current electrochemical methods rely on the use of redox mediators, which may produce corrosive intermediates, while direct oxidation is still limited by its low activity and selectivity. Herein, we conducted electrochemical studies to obtain mechanistic insights into the benchmark Pd catalyst. The generated Pd(II) could be the active site for C₂H₄ oxidation. By designing the pulse sequence, we found the ratio of strongly and weakly adsorbed C₂H₄ on Pd to be 0.3:1. The result we …

Recent Advances In Exploring Highly Active & Durable Pgm-Free Oxygen Reduction Catalysts, Yuan Li, Miao-Ying Chen, Bang-An Lu, Jia-Nan Zhang

Journal of Electrochemistry

In order to reduce the considerable usage of expensive but scarce platinum at the cathode in proton exchange membrane fuel cells (PEMFCs), it is necessary to pursue alternatives to platinum. The most promising platinum group metal (PGM)-free catalysts for oxygen reduction reaction (ORR) are atomically dispersed, and nitrogen-coordinated metal site catalysts denoted as M-N-C (M = Fe, Co, or Mn, etc.). Over the last few decades, there have been great advances in these catalysts with high ORR activity and promising initial fuel cell performance approaching traditional Pt/C catalysts. However, the stability of these highly active Fe-N-C catalysts under practical fuel …

Research Progress In Cucurbit[N]Uril-Based Metal Nanomaterials For Electrocatalytic Applications, Zong-Nan Wei, Min-Na Cao, Rong Cao

Journal of Electrochemistry

Metal nanomaterials have exhibited excellent performance in electrocatalytic applications, but they still face the problems of poor stability and limited regulation strategies. It is an efficient strategy for greatly enhanced catalytic activity and stability by introducing a second component. In this review, we provide the sketch for the combination of metal nanomaterials and cucurbit[n]urils (CB[n]s) in electrocatalytic applications. CB[n]s are a series of macrocycles with rigid structure, high stability, and function groups for coordinating with metal sites, which make them promising to stabilize and modulate the metal nanomaterials for ideal performance. The discussion classifies the roles of CB[n]s, involving CB[n]s …

Supperlattice-Like Structure: Ordered Mass Transfer Endowing High Quality Output Of Fuel Cell, Jian Wang, Wen-Hui Xuan, Qian He, Jing-Xia Jiang, Yuan-Yuan Zhou, Yao Nie, Qiang Liao, Min-Hua Shao, Wei Ding, Zi-Dong Wei

Journal of Electrochemistry

The current or voltage fluctuation in fuel cell operation is harmful to the fuel cell system and power application equipment. Here, we report a technique to eliminate such a fluctuation by the aid of new type of catalysts, superlattice-like mesoporous PtCo catalysts. The current fluctuation in fuel cells catalyzed by two invented catalysts are fixed at as low as 25 mA·cm⁻² with a power of 0.75 W·cm⁻² or 120 mA·cm⁻² with a power of 1.01 W·cm⁻², and no noticeable current decay was detected over 100 h. By contrast, a …

The “Nitrogen Effect”: Complexation With Macrocycles Potentiates Fused Heterocycles To Form Halogen Bonds In Competitive Solvents, Dr. Kwaku Twum, Sanaz Nadimi, Frank Boateng Osei, Dr. Rakesh Puttreddy, Dr. Yvonne Bessem Ojong, Dr. John J. Hayward, Prof. Kari Rissanen, Prof. John F. Trant, Prof. Ngong Kodiah Beyeh Kodiah Beyeh

Chemistry and Biochemistry Publications

Weak intermolecular forces are typically very difficult to observe in highly competitive polar protic solvents as they are overwhelmed by the quantity of competing solvent. This is even more challenging for three-component ternary assemblies of pure organic compounds. In this work, we overcome these complications by leveraging the binding of fused aromatic N-heterocycles in an open resorcinarene cavity to template the formation of a three-component halogen-bonded ternary assembly in a protic polar solvent system.

In-Vial Detection Of Protein Denaturation Using Intrinsic Fluorescence Anisotropy, Krishnakumar Chullipalliyalil, Khaled Elkassas, Michael Mcauliffe, Sonja Vucen, Abina Crean

Cappa Publications

The conventional quality control techniques for identifying the denaturation of biopharmaceuticals includes sodium dodecyl sulfate-polyacrylamide gel electrophoresis for identifying fragmentation, ion exchange chromatography and isoelectric focusing for identifying deamidation, reverse-phase high-performance liquid chromatography (HPLC) for identifying oxidation, and size-exclusion HPLC for identifying aggregation. These stability assessments require essential processes that are destructive to the product tested. All these techniques are lab based and require sample removal from a sealed storage vial, which can breach the sterility. In this work, we investigate the heat- and surfactant-induced denaturation of an in-vial-stored model protein, bovine serum albumin (BSA), by analyzing its intrinsic fluorescence …

Lysine Crosslinked Polyacrylamide─A Novel Green Polymer Gel For Preferential Flow Control, Tao Song, Baojun Bai, Yugandhara Eriyagama, Thomas P. Schuman

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Acrylamide-based polymer gels have been applied to control the preferential flow in the subsurface for decades. However, some commonly used crosslinkers, such as Cr (III) and phenol-formaldehyde, are highly toxic and are being phased out because of stringent environmental regulations. This work uses l-lysine as the green crosslinker to produce acrylamide-based polymer gels. This article systematically studied the effect of lysine and polymer concentration, salinity, pH, and temperature on gelation behavior and thermal stability. Besides, the gelation mechanism and crosslinking density were elucidated in this work. A high-permeability sandstone core was used to test the plugging efficiency of this novel …

Serendipitous Synthesis Of Cross-Conjugated Dienes By Cascade Deconstructive Esterification Of Thiomorpholinone-Tethered Alkenoic Acids, Abdikani Omar Farah, Jorge Garcia, Claire Borg, Timothy K. Beng

Student Published Works

Functionalized 1,3-dienes are ubiquitous structural motifs in biologically pertinent molecules. They are frequently employed as precursors for a broad range of chemical transformations, including Diels-Alder reactions. The stereoselective construction of highly decorated 1,3-dienes therefore represents an important research objective. Medicinal chemists are becoming increasingly interested in synthetic methodologies that not only achieve expedient construction and peripheral editing of heterocycles, but also seek to modify their core framework in order to achieve skeletal remodeling. In a succinct manifestation of this 'scaffold hopping' concept, we herein describe a cascade reaction, which converts thiomorpholinone-tethered alkenoic acids to 1,1-disubstituted amino-1,3-dienes. This domino process involves …

Essential Oils Composition And Biological Activity Of Chamaecyparis Obtusa, Chrysopogon Nigritanus And Lavandula Coronopifolia Grown Wild In Sudan, Loai M H Eltayeb, Sakina Yagi, Hanan M M Mohamed, Gokhan Zengin, Mohammad Ali Shariati, Maksim Rebezov, Abdullah Ibrahim Uba, Jose Manuel Lorenzo

College of Science & Mathematics Departmental Research

Generally, there are scant data about the constituents and eventually the biological activity of essential oils (EOs) from aromatic plants that grow naturally in Sudan. The present study aimed to determine the chemical composition, and antioxidant and enzyme inhibitory activities of EO extracted from the fruit of Chamaecyparis obtusa (Siebold and Zucc.) Endl. (family Cupressaceae), root of Chrysopogon nigritanus (Benth.) Veldkampis (family Poaceae) and aerial part of Lavandula coronopifolia Poir (family Lamiaceae). The fruit of C. obtusa contained only monoterpenes, mainly hydrogenated ones, with α-pinene (69.07%) as the major component. Oxygenated sesquiterpenes comprised the highest content of the C. nigritanus …