Physical Sciences and Mathematics Commons^™

Creating Monolayers And Thin Films Of A Novel Bis(Alkyl) Substituted Asymmetrical Polyoxotungstate, {[Ch3(Ch2)11si]2osiw11o39}42 Using The Langmuir–Blodgett Technique, R. Carlisle Chambers, Elizabeth J. Osburn Atkinson, David Mcadams, Eric J. Hayden, Davida Ankeny Brown

Faculty Publications - Department of Biological & Molecular Science

No abstract provided.

Hypothalamic Proopiomelanocortin Neurons Are Glucose Responsive And Express Katp Channels, Nurhadi Ibrahim, Martha A. Bosch, James L. Smart, Jian Qiu, Marcelo Rubinstein, Oline K. Rønnekleiv, Malcolm J. Low, Martin J. Kelly

Faculty Publications - Department of Biological & Molecular Science

Hypothalamic proopiomelanocortin (POMC) neurons are critical for controlling homeostatic functions in the mammal. We used a transgenic mouse model in which the POMC neurons were labeled with enhanced green fluorescent protein to perform visualized, whole-cell patch recordings from prepubertal female hypothalamic slices. The mouse POMC-enhanced green fluorescent protein neurons expressed the same endogenous conductances (a transient outward K current and a hyperpolarization-activated, cation current) that have been described for guinea pig POMC neurons. In addition, the selective -opioid receptor agonist DAMGO induced an outward current (maximum of 12.8 1.2 pA), which reversed at K equilibrium potential (EK), in the majority …

Analysis Of Phycotoxin And Mycotoxin, Contaminants In Foods, Using Liquid Chromatography - Mass Spectrometry Techniques, Ana Brana Magdalena

Theses

The impact of phycotoxins and mycotoxins on human and animal health are of important concern for worldwide authorities and the scientific community. Liquid chromatography-mass spectrometry (LC-MS) techniques have been developed, optimised and validated for the analysis of these toxins.

Phycotoxins are potentially toxic substances, which are produced by marine phytoplankton and which may accumulate in shellfish or finfish. Azaspiracid poisoning (AZP) is a recently discovered syndrome that has been implicated in several incidents of human intoxications. A study was undertaken to examine the distribution of azaspiracids (AZA) in scallops {Pecten maximiis) and mussels {Mytiliis edulis). Domoic acid (DA) is an …

The Microwave Spectrum, Ab Initio Analysis, And Structure Of The Fluorobenzene–Hydrogen Chloride Complex, M. Eugenia Sanz, Sonia Antolinez, Jose Alonso, Juan Lopez, Robert Kuczkowski, Sean Peebles, Rebecca Peebles, Faith Boman, Elfi Kraka, Dieter Cremer

Faculty Research and Creative Activity

The fluorobenzene–hydrogen chloride π-hydrogen-bonded complex has been studied by high resolution microwave spectroscopy and ab initio calculations. Rotational spectra of the C6H5F–H35Cl, C6H5F–H37Cl, and C6D5F–H35Cl isotopomers were assigned using pulsed molecular beam techniques in a Fourier-transform microwave spectrometer. The spectra are consistent with a structure of the complex in which the HCl is above the fluorobenzene ring near the ring center, similar to the benzene–HCl prototype dimer. An analysis of the inertial data and the chlorine quadrupole coupling tensor results in two mathematically possible locations for the HCl subunit with respect to the fluorobenzene arising from sign ambiguities in interpreting …

The Microwave Spectrum, Ab Initio Analysis, And Structure Of The Fluorobenzene–Hydrogen Chloride Complex, M. Eugenia Sanz, Sonia Antolinez, Jose L. Alonso, Juan C. Lopez, Robert L. Kuczkowski, Sean A. Peebles, Rebecca A. Peebles, Faith C. Boman, Elfi Kraka, Dieter Cremer

Faculty Research and Creative Activity

The fluorobenzene–hydrogen chloride π-hydrogen-bonded complex has been studied by high resolution microwave spectroscopy and ab initio calculations. Rotational spectra of the C6H5F–H35Cl, C6H5F–H37Cl, and C6D5F–H35Cl isotopomers were assigned using pulsed molecular beam techniques in a Fourier-transform microwave spectrometer. The spectra are consistent with a structure of the complex in which the HCl is above the fluorobenzene ring near the ring center, similar to the benzene–HCl prototype dimer. An analysis of the inertial data and the chlorine quadrupole coupling tensor results in two mathematically possible locations for the HCl subunit with respect to the fluorobenzene arising from sign ambiguities in interpreting …

Silica Supported Copper Complexes And Their Biomimetic Activities, Jun Wang

Dissertations, Theses, and Masters Projects

No abstract provided.

Synthetic And Mechanistic Studies Of Poly(Vinyl Chloride) And Some Other Chlorinated Polymers, Xianlong Ge

Dissertations, Theses, and Masters Projects

Unlike vinyl chloride, 1,2-dichloroethylene (DCE) experienced dimerization under free-radical conditions. Chain transfer to DCE by beta-Cl elimination was shown to be the major reason for its nonpolymerization.;During the chlorination of alkyl chlorides with molecular chlorine, the involvement of a bridged intermediate led to the formation of vicinal chlorides as the major products. The yields of geminal chlorides increased significantly in the presence of solvents that form complexes with chlorine atoms, but such solvents also decreased the reactivity of the chlorination. Thus the chlorination of poly(vinyl chloride) (PVC) in the presence of complexing solvents was not a useful method for the …

Transport Analysis In Polymeric Liquids And Films: Investigations In Ionic Mobility Isolation Techniques And Permeability Control, Julia D. Warner

Dissertations, Theses, and Masters Projects

An in situ measurement technique that isolates the mobility of charge carriers is described and analyzed. The technique allows significant improvement over conductivity measurements to monitor changes in the physical properties and state of a material as it cures. This is essential in systems where Ni, the number of charge carriers, cannot be assumed constant such as during cure of epoxies, urethanes and polyimides.;Currently, there is an assumption made in the literature that the number of charge carriers present in a curing material is constant when conductivity is used as an in situ measurement technique to monitor changes in mobility. …

Crystal Structure Of Boc-Trp(Cho)-Dphe-Ile-Dphe-Leu-Och3, C48h59n6o10, Vijayaraghavan Rangachari, J. Makker, P. Kumar, S. Dey, Tej P. Singh

Faculty Publications

No abstract provided.

Heterogeneous Photocatalytic Reduction Of Ferrate(Vi) In Uv-Irradiated Titania Suspensions: Role In Enhancing Destruction Of Nitrogen-Containing Pollutants, Virender K. Sharma, Kurt Winkelmann, Yekaterina Krasnova, Changyoul Lee, Mary Sohn

Chemistry and Chemical Engineering Faculty Publications

The results of the heterogeneous photocatalytic reduction of Fe(VI) in UV-irradiated TiO2 suspensions are presented and suggest indirect observation of the formation of Fe(V) by the photoreduction of Fe(VI) with ecb- at TiO2 surfaces. Because Fe(V) selectively and rapidly oxidizes low reactivity pollutants with the production of the non-toxic by-product, Fe(III), the photocatalytic reduction of Fe(VI) has a role in pollution remediation processes. The experiments were conducted as a function of TiO2 suspension concentrations, Fe(VI) concentrations, and pH in basic media. The initial rate of Fe(VI) reduction gave a fractional order with respect to initial Fe(VI) concentrations and adheres to …

The Synthesis Of 2-(1-Indenyl)-Phenol: A Potential Ligand For Metallocene Polymerization Catalysts; And, Ω-Iodoalkyl(Methyl) Malonate Esters: Synthesis And Application In Bioconjugate Chemistry, Sara E. Bendler

Masters Theses

Chapter I:

Metallocene catalysis is an important division of polymerization chemistry. The design of appropriate ligands for metallocene catalysts has focused on stereochemical control and structural diversity. The synthesis of the potential ligand 2-(1-indenyl)-phenol has been developed. Indenyl phenol ligands offer advancements over cyclopentadienyl ligands because the steric and electronic properties of the catalyst could be tailored to suit individual polymerization reactions. 2-(1-Indenyl)-phenol was synthesized with an overall yield of 4% and characterized with ¹H NMR and ¹³C NMR.

Chapter II:

A large percentage of breast malignancies overexpress the nuclear estrogen receptor (ER) protein. Binding to nuclear receptors …

Dmap As A Catalyst For Carbon Acylation: Elucidation Of Mechanistic Pathway, Including Spectral Characterization Of The Putative Reactive Intermediate, Jagadish K. Boppisetti

Masters Theses

3-Phenylbenzofuranone, when deprotonated with sodium hydride, forms an extended enolate system which, when treated with excess alkyl chloroformates, affords only oxygen-acylated products, as opposed to the usually desired carbon-functionalized derivatives. It was discovered that such molecules, when treated with a catalytic amount of 4- (N, N-dimethylamino)pyridine (DMAP), rearrange quantitatively to the carbon acylated isomers.

These migrations, which are accompanied by a deep blue color, are proposed to involve a reactive intermediate. This intermediate, which is postulated as an ion pair charge transfer (IPCT) complex, has been closely studied in order to gain a better understanding of the …

Nitroalkane Anomaly: Computational Study With Cluster And Continuum Modeling, H. Yamataka, Salai Cheettu Ammal

Faculty Publications

The origin of anomalous relation between rates and equilibria for the proton-transfer reactions of nitroalkanes, known as nitroalkane anomaly, was investigated by theoretical calculations with a cluster model, in which three water molecules are explicitly considered in the system, as well as the PCM solvent continuum model. For the CH3NO2/CH3CH2NO2 system, B3LYP and MP2 computations reproduced the anomaly, and the imbalance in the charge distribution at the transition state (TS) was observed. In contrast, although the TS imbalance was detected for the substituted phenylnitromethane system, the Brønsted plots did not show any anomaly. The experimentally observed abnormally large Brønsted coefficient …

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

Ft-Ir Studies Of Stereo Regular Pmma On Silica: Drying Effects, Bing Zhang, Suntree Kulkeratiyut, Suriyaphongse Kulkeratiyut, Frank D. Blum

Chemistry Faculty Research & Creative Works

A great amount of work has been done on the configuration of surface adsorbed poly(methyl methacrylate) (PMMA), especially on surfaces to which they have a strong attraction. Some studies have been make on the relationships between configuration and tacticity, molecular weight, adsorbed amount, and density of surface hydroxyl groups. The effect of tacticity on the conformation of alumina-adsorbed PMMA in solution and dry spin-coated films were studied by Grohen et al. Their results showed that surface-adsorbed PMMA chains adopted a relatively flat configuration, but iso-PMMA (isotactic) adsorbed on aluminum, with a much larger fraction of the bound carbonyl groups, had …

President's Message

Journal of the South Carolina Academy of Science

No abstract provided.

Par Mediation Of Thrombin-Induced Effects On Motoneurons, Nadim Salman, Drew Watkins, Kate Hamel, Lakisha Gadsden, Sarah Funderburk, Victoria Turgeon

Journal of the South Carolina Academy of Science

No abstract provided.

Some Notes On Multiplicative Congruential Random Number Generators With Mersenne Prime Modulus 261-1., James Harris

Journal of the South Carolina Academy of Science

No abstract provided.

Embryogenesis In The Japanese Medaka, Oryzias Latipes, Laura Harris Harris, Lisa Sims, Roxann Stachiw

Journal of the South Carolina Academy of Science

No abstract provided.

Critical Thinking And Biology Instruction., David J. Stroup, John L. Frola

Journal of the South Carolina Academy of Science

No abstract provided.

Phosphido-Bridged Complexes Linked By Unsaturated Phosphines, Yong Liu

Masters Theses

Di(p-tol)phosphido-bridged complexes, (OC)₄M[μ-P(p-tol)₂]₂M(CO)₄ (M = Mo, W), have been synthesized for the first time. These have been obtained from the reaction of (OC)₅MP(p-tol)₂H with BuLi, followed by air oxidation. The choice of solvent is very important as the intermediate anion, [(OC)₅MP(p-tol)₂] is unstable in THF. An ideal solvent for these preparations is CH₃OCH₂CH₂OCH₃ (monoglyme) from which yields of 68% and 76% were realized for the tungsten and molybdenum complexes, respectively. …

Chlorobenzenes And Chloronitrobenzenes Interaction With Iron (O), Manuel Alejandro Serratos

Masters Theses

Degradation of chlorobenzene, dichlorobenzenes and chloronitrobenzenes (ClB, x-Cl2B and x-ClNO2B) was tested by trying to make them react with metallic iron, Fe (0), in water solvent.

The experiments consisted of optimizing the parameters of the reactions (like minimum mass of iron needed) and analytical detection conditions. Analytical techniques used were gas and liquid chromatography (GC and HPLC), mass spectrometry (MS) and UV-Vis spectroscopy.

No substances other than the initial ClB and x-Cl2B were detected in their tests with Fe (0) after shaking for periods of up to three days, although 10%weight average decreases in concentration were observed.

The ClNO2B isomers …

Synthesis And Characterization Of A Polypyridyl Ru(Ii)-Alloxazine Complex For Adsorption On Tio2-Coated Ito Electrodes, Manisha A. Patel

Masters Theses

TiO₂-coated conducting glass electrodes can be modified by attachment of redox-active molecules to the TiO₂ surface. This thesis describes the synthesis and characterization of a polypyridyl Ru(II) complex that can be covalently bound to a TiO₂ surface through the carboxylate groups of 2,2'-bipyridine-4,4' -dicarboxylic acid, H₂dcbpy. In addition, the bound complex contains a redox-active alloxazine derivative, pptd, which is capable of 2e^-/2H⁺ transfers. Thus the TiO₂-coated electrode is modified with a transition metal complex capable of shuttling H-atoms to substrates in solution. Synthesis of the PF₆^- salt …

Diffusion Of A Rodlike Virus In Complex Solutions, Randall Charles Cush

LSU Doctoral Dissertations

Entanglement phenomena in concentrated polymer solutions remain an interesting and challenging problem. It is still unclear how entanglement onset affects polymer chain motion at small distance scales. One way to study such motion is to follow the diffusion of a probe particle while increasing the concentration of the polymer. Many such studies have been done using probes ranging from linear and star polymers to various colloidal particles; however, relatively few studies have used rodlike probes. Rodlike probes are potentially more interesting due to the added information that may be gained by following rotational as well as translational diffusion. The anisotropic …

Genome Analysis: Mutation Analysis Using Near Infrared Laser-Induced Fluorescence (Nir-Lif) And Single Molecule Detection In Microfluidic Devices, Musundi Ben Wabuyele

LSU Doctoral Dissertations

A number of genotyping methods have been developed for mutation analysis, each of which has its own unique advantage. DNA amplification via polymerase chain reaction (PCR) provides an unlimited supply of material for subsequent genetic analysis even in case where only a single copy of the DNA molecule is present in the sample. Research presented in this dissertation first examines the efficiency of in vitro amplification of single copy DNA with subsequent sequencing analysis of PCR product. The PCR products (amplicons) were investigated for possible alteration, distortions or mutations due to the amplification process. The sequencing data for single copy …

Design And Synthesis Of Handles For Solid-Phase Peptide Synthesis And Convergent Peptide Synthesis, Jose Giraldes

LSU Doctoral Dissertations

The recent popularity of methods for solid-phase peptide synthesis that use the 9-fluorenylmethyloxycarbonyl (Fmoc) group for N^α-amino protection has created a need for compatible anchoring linkages and handles. In an effort to develop mild new methods for use in solid-phase peptide synthesis (SPPS), a new ferrocene containing linker or “handle”, the 1’1-ferrocenyl carboxaldehyde handle was designed, synthesized, characterized and tested. This linker is analogous to those commercially available and developed by Barany. The ferrocenyl amine linker(FAL) releases C-terminal peptide amides upon acidolysis. Since the FAL handle is acid labile it is compatible with Fmoc and N^α-dithiasuccinoyl …

Design And Synthesis Of Constrained Dipeptide Units For Use As Β-Sheet Promoters, Umut Oguz

LSU Doctoral Dissertations

The study of factors promoting beta-sheet formation has recently gained interest due to the suspected involvement of beta-sheets in brain degenerative diseases such as Alzheimer's disease (AD), Creutzfeldt-Jacob disease (CJD) and bovine spongiform encephalopathy. Understanding beta-sheet formation and the factors that stabilize beta-sheet structure may serve as a basis for future drug design. The extended structure of a beta-sheet can be stabilized by constrained amino acid analogs that are pre-organized to adopt the extended conformation. In this dissertation using innovative synthetic organic chemistry methods, two dipeptide units are designed and synthesized that are constrained to form the extended conformation and …

Design, Synthesis, And Applications Of Bio-Derived Crosslinking Monomers For Molecular Imprinting, Martha Sibrian-Vazquez

LSU Doctoral Dissertations

Most of the research in the field of molecular imprinting has been focused on the development of new functional monomers, in order to improve the molecular recognition properties afforded by these materials. The role of the crosslinking monomer has often been overlooked, since it is considered an inert component that only provides a scaffold to support the binding sites. However, the crosslinking monomer represents a high percent (80-90%) of the composition of molecularly imprinted polymers (MIPs), which can have a large influence on the MIPs properties. This research addresses the design, synthesis, and applications of new crosslinking monomers for molecular …

Synthesis, Characterization, And Application Of Water-Soluble Chiral Calix[4]Arene Derivatives In Spectroscopy And Capillary Electrokinetic Chromatography, Kim Hamilton

LSU Doctoral Dissertations

This dissertation is an account of the synthesis, characterization, and application of novel water-soluble chiral calixarenes in spectroscopy and capillary electrophoresis. It is divided into four sections. The first part describes the synthesis and nuclear magnetic resonance (NMR) characterization of four p-t-butylcalix[4]arenes bearing L-amino acid moieties on their lower rims (CX4-AA). The structure and conformation of the derivatives have been determined using one- and two-dimensional NMR techniques. Proton and carbon-13 spectra show that the derivatives are tetra-substituted and adopt a cone conformation. The preparation and characterization of silica-bonded calixarene stationary phases for capillary electrochromatography is also reported in Chapter 2. …

Characterization Of Native And Bypass Human Coronary Artery Plaque Deposits From The Same Heart: Investigation Of The Chemical Form Of Calcium In Human Coronary Artery Plaque Deposits, Serigne Thiam

LSU Doctoral Dissertations

Gradual deposits of lipids, proteins, and calcium on the coronary arterial walls cause atherosclerosis, leading to blockage of the blood flow and possible heart attack. Despite many studies, the mechanism underlying these processes remains unclear. In this research, differences between native and bypass plaque deposits from the same heart were examined. In addition, the crystalline and the amorphous plaques within these native and bypass vessels were characterized. The techniques used to characterize the deposits included inductively coupled plasma mass spectrometry (ICPMS), solid-state nuclear magnetic resonance (NMR), high performance liquid chromatography (HPLC), etc. The results from the ICPMS technique showed that …