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Full-Text Articles in Physical Sciences and Mathematics

Blood Coagulation Factor Ix: Purification, Activation, Crystallization, Juliet Mcgill Oct 2023

Blood Coagulation Factor Ix: Purification, Activation, Crystallization, Juliet Mcgill

WWU Honors College Senior Projects

This paper presents readers with an optimized procedure for the purification, activation, and crystallization of selected blood coagulation Factor IX double mutant (FIX_2). Through the completion of this work, we aim to enhance future biochemical and structural studies by providing an easier means for the FIX_2 production, in order to increase understanding of the protein’s function within the blood coagulation cascade. The initiation of the blood coagulation cascade is brought on by activation of inactive Factor VIII (FVIII) protein though contact with tissue factor, the FVIII protein then binds to an activated platelet surface where it must wait for its …

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H5n1 Highly Pathogenic Avian Influenza Clade 2.3.4.4b In Wild And Domestic Birds: Introductions Into The United States And Reassortments, December 2021–April 2022, Sungsu Youk, Mia Kim Torchetti, Kristina Lantz, Julianna B. Lenoch, Mary Lea Killian, Christina Leyson, Sarah N. Bevins, Krista Dilione, Hon S. Ip, David E. Stallknecht, Rebecca L. Poulson, David L. Suarez, David E. Swayne, Mary J. Pantin-Jackwood Oct 2023

H5n1 Highly Pathogenic Avian Influenza Clade 2.3.4.4b In Wild And Domestic Birds: Introductions Into The United States And Reassortments, December 2021–April 2022, Sungsu Youk, Mia Kim Torchetti, Kristina Lantz, Julianna B. Lenoch, Mary Lea Killian, Christina Leyson, Sarah N. Bevins, Krista Dilione, Hon S. Ip, David E. Stallknecht, Rebecca L. Poulson, David L. Suarez, David E. Swayne, Mary J. Pantin-Jackwood

United States Department of Agriculture Wildlife Services: Staff Publications

Highly pathogenic avian influenza viruses (HPAIVs) of the A/goose/Guangdong/1/1996 lineage H5 clade 2.3.4.4b continue to have a devastating effect on domestic and wild birds. Full genome sequence analyses using 1369 H5N1 HPAIVs detected in the United States (U.S.) in wild birds, commercial poultry, and backyard flocks from December 2021 to April 2022, showed three phylogenetically distinct H5N1 virus introductions in the U.S. by wild birds. Unreassorted Eurasian genotypes A1 and A2 entered the Northeast Atlantic states, whereas a genetically distinct A3 genotype was detected in Alaska. The A1 genotype spread westward via wild bird migration and reassorted with North American …

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Limited Accumulation And Persistence Of An Influenza A Virus In Tadpole Snails (Physa Spp.), Paul T. Oesterle, J. Jeffrey Root, Darcy S.O. Mora, Heather Schneider, Alan B. Franklin, Kathryn P. Huyvaert Oct 2023

Limited Accumulation And Persistence Of An Influenza A Virus In Tadpole Snails (Physa Spp.), Paul T. Oesterle, J. Jeffrey Root, Darcy S.O. Mora, Heather Schneider, Alan B. Franklin, Kathryn P. Huyvaert

United States Department of Agriculture Wildlife Services: Staff Publications

Waterfowl infected with avian influenza A viruses (IAVs) shed infectious virus into aquatic environments, providing a mechanism for transmission among waterfowl, while also exposing the entire aquatic ecosystem to the virus. Aquatic invertebrates such as freshwater snails are likely exposed to IAVs in the water column and sediment. Freshwater snails comprise a significant portion of some waterfowl species’ diets, so this trophic interaction may serve as a novel route of IAV transmission. In these experiments, tadpole snails (Physa spp.) were exposed to a low-pathogenicity IAV (H3N8) to determine whether snails can accumulate the virus and, if so, how long virus …

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Do Microplastics, Vibrio Bacteria, And Warming Water Temperatures Cause Disease In The Northern Star Coral, Astrangia Poculata?, Heather Leigh Sheffey Oct 2023

Do Microplastics, Vibrio Bacteria, And Warming Water Temperatures Cause Disease In The Northern Star Coral, Astrangia Poculata?, Heather Leigh Sheffey

OES Theses and Dissertations

As marine plastic pollution increases, it becomes imperative to study the effects of microplastics on marine fauna. Marine plastic debris is a vector for disease to marine invertebrates (Lamb et al., 2018; Rotjan et al., 2019). In this context, studies have shown Astrangia poculata will consume microplastics as they do their normal food (Allen et al, 2017; Rotjan et al., 2019). Further, with temperatures increasing worldwide, there is a concern the virulence of disease-causing bacteria will increase (Vezzulli et al., 2015). In a series of manipulative laboratory experiments, this study quantified changes in respiration rates and visual health of Astrangia …

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Organic Carbon Decay Mediated By Mesopelagic Microbial Communities, Noah Jonathan Craft Oct 2023

Organic Carbon Decay Mediated By Mesopelagic Microbial Communities, Noah Jonathan Craft

OES Theses and Dissertations

Substantial remineralization of organic carbon occurs in the mesopelagic zone (i.e., the biological pump), the efficiency of which is responsible for the oceans’ capacity to store carbon originally derived from the atmosphere. To better understand how a substrate’s composition influences its degradation by mesopelagic microbial communities, we added treatments made of live algal cells, dead particulate organic carbon and dissolved organic carbon from 14C-labeled algal cultures to mesopelagic water collected in-situ. Each incubation took place in the laboratory over a period of months, during which PO14C, DO14C, ATP, prokaryote abundances and biochemical fractions were measured. …

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Dental Hygiene Students Reported Physiological Symptoms Associated With Wearing An N95 Respirator Mask, Peyton Shea Butler Oct 2023

Dental Hygiene Students Reported Physiological Symptoms Associated With Wearing An N95 Respirator Mask, Peyton Shea Butler

Dental Hygiene Theses & Dissertations

Purpose: Physiological symptoms and comfort levels while wearing an N95 respiratory mask has not been examined with dental hygienists. The purpose of this study was to investigate dental hygiene students reported physiological symptoms and comfort perception while wearing an N95 respirator mask during patient care appointments. Methods: After IRB approval (IRB #1987754-2), a 16-item questionnaire was distributed through email to a convenience sample of 65 dental hygiene students. Questions assessed respiratory, dermatologic, cardiac, mask mouth and general physiological symptoms, as well as comfort levels. Additionally, participants were asked to respond to demographic questions and one open ended question inquiring about …

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Primates And Pregnancy: Lessons In Childbirth From Human Evolution, Amelia Merithew Oct 2023

Primates And Pregnancy: Lessons In Childbirth From Human Evolution, Amelia Merithew

The Synapse: Intercollegiate science magazine

No abstract provided.

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Green Promise Or Environmental Threat?: Corn Ethanol’S Positive And Negative Effects, Sydney Rosensaft Oct 2023

Green Promise Or Environmental Threat?: Corn Ethanol’S Positive And Negative Effects, Sydney Rosensaft

The Synapse: Intercollegiate science magazine

No abstract provided.

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Computational Investigation Of Mononuclear Iron Water Oxidation Catalyst Design, Kristal Stevens, Emily Jarvis Oct 2023

Computational Investigation Of Mononuclear Iron Water Oxidation Catalyst Design, Kristal Stevens, Emily Jarvis

Chemistry and Biochemistry Faculty Works

Hydrogen production from non-carbon sources is an essential component of clean and sustainable technology for reducing greenhouse gas emissions from fuels. Water oxidation, which splits water molecules into hydrogen (protons) and molecular oxygen, is a thermodynamically challenging, multistep reaction achieved in photosynthetic organisms via photocatalysis by the Oxygen Evolving Complex (OEC) of Photosystem II. Mononuclear water oxidation catalysts that aim to mimic nature typically rely on heavy, rare metals such as ruthenium and iridium. Replacing these metals with iron is particularly appealing because it is abundant, benign, and inexpensive. We use density functional theory to characterize the catalytic ability of …

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Portugal To New Mexico: Investigating The Applicability Of Syntropic Agriculture To A Semi-Arid Continental Climate, Arielle Nathan Oct 2023

Portugal To New Mexico: Investigating The Applicability Of Syntropic Agriculture To A Semi-Arid Continental Climate, Arielle Nathan

Independent Study Project (ISP) Collection

Conventional industrial agriculture has numerous detrimental effects on the environment including high carbon emissions, pollution and overconsumption of water, soil degradation, and reduction of biodiversity (FAO, 2018). Large-scale alternatives are needed to combat these negative consequences and provide climate solutions. Syntropic Agriculture is a promising farming alternative especially in arid systems subject to degraded soils and desertification. New Mexico is a semi-arid continental climate in a prolonged period of drought and predicted to experience worsening agricultural conditions due to desertification, wildfire intensification, and exacerbated water scarcity. In an area with similar agricultural challenges, a project in Mértola, Portugal (Terra Sintrópica) …

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Inequality Of Air Quality?: A Study Of Air Quality Within Housing Price Brackets In Gettysburg, Pa, Jess G. Schaefer, Alexis J. Jones, Arden H. Dowd Oct 2023

Inequality Of Air Quality?: A Study Of Air Quality Within Housing Price Brackets In Gettysburg, Pa, Jess G. Schaefer, Alexis J. Jones, Arden H. Dowd

Student Publications

With the rise of cars and other motorized vehicles has come the rise of air pollution, which tends to have disproportionate environmental and health impacts on low-income and communities of color. This study analyzes car presence and air quality on a transect within Gettysburg, PA to determine if there is a relationship between air pollution and vehicle presence, and if there is a difference in air quality between higher price bracket housing compared to campus, commercial, and lower price bracket housing. To test our research questions, we identified nine sampling locations along a transect where we measured air pollutants, including …

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Analyzing The Ramifications Of Climate Change On Mental Health, Salvatore A. Medori Oct 2023

Analyzing The Ramifications Of Climate Change On Mental Health, Salvatore A. Medori

Student Publications

When thinking about the vast array of impacts that the climate crisis has on humanity, there are many things that come to mind, but mental health impacts are likely not one of them. Even though research demonstrates that mental effects from any form of disaster far exceed the physical health implications mental health impacts of the largest disaster facing humanity since the Second World War are rarely considered at all, let alone when solutions are being created. This has led to a hidden crisis emerging underneath an even larger crisis, with serious consequences for most individuals across the globe. The …

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Clean Water Saves Lives: Improving Clean Water Access In Yeakpee Town, Liberia, Mishael F. Ohanwadi Oct 2023

Clean Water Saves Lives: Improving Clean Water Access In Yeakpee Town, Liberia, Mishael F. Ohanwadi

Student Publications

Civil unrest in Liberia, a West Coast African nation, has caused the destruction of essential infrastructure, particularly water, sanitation, and hygiene (WASH) systems. As a result, there is a high reliance on unsafe water sources and prevalence of waterborne diseases and health issues, particularly in the Yeakpee Town Community. Inadequate funding has hindered progress, and there are connections between gender inequalities and limited access to clean water. The Clean Water Save Lives project, launched in 2020, aimed to provide sustainable access to clean water in Yeakpee Town community by constructing a water pump with a filtration system. The project aimed …

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On The Rocks, Below The Rocks: A Study Of Intertidal Life In The Low, Middle And High Zones Of The Puerto Cabuyal – Punta San Clemente Marine Reserve During An El Niño Event, Juliana M. Ferrer Oct 2023

On The Rocks, Below The Rocks: A Study Of Intertidal Life In The Low, Middle And High Zones Of The Puerto Cabuyal – Punta San Clemente Marine Reserve During An El Niño Event, Juliana M. Ferrer

Independent Study Project (ISP) Collection

The rocky intertidal zone is one of the most difficult environments for organisms to survive in due to its harsh biotic and abiotic conditions. As such, it is also one of the best indicators of climate change and an important barrier to beach erosion. This study looked at the rocky intertidal zone of the Puerto Cabuyal-Punta San Clemente Marine Reserve in the Manabí province of Ecuador, with a focus on observing and identifying the organisms found in the area. Data was collected along 30 m transects at varying elevations along the shore using quadrants of two sizes: 50x50 cm for …

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Friends In High Places: Establishing Pollination Networks For The Páramos Of Central Ecuador, Emma Diaz Oct 2023

Friends In High Places: Establishing Pollination Networks For The Páramos Of Central Ecuador, Emma Diaz

Independent Study Project (ISP) Collection

Well-known for being a global biodiversity hotspot, the Andean Páramos hosts a unique array of floristic diversity seen nowhere else in the world (Luteyn, n.d.). With the resiliency of this ecosystem dependent on the successful reproduction of these plants, it is crucial to understand the pollination network which sustains them. Modern-day research has outlined networks in the Chilean, Venezuelan, and Argentinean Páramos, but one has yet to be defined for Ecuador, despite being the suspected home to nearly half of floristic diversity in the Páramos (Arroyo et al., 1985; Pelayo et al., 2021; Medan et al., 2023; Caranqui et al., …

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Community Complexity Of A Pollination Network: Analysis Of Plant-Pollinator Interactions In The Eastern Ecuadorian Cloud Forest, Anisa López-Ruiz Oct 2023

Community Complexity Of A Pollination Network: Analysis Of Plant-Pollinator Interactions In The Eastern Ecuadorian Cloud Forest, Anisa López-Ruiz

Independent Study Project (ISP) Collection

Global declines in pollinators and temporal/spatial mismatches between plants and pollinators threaten the integrity of plant-pollinator networks. Ecological network analysis provides a powerful framework for understanding the dynamics of plant-pollinator networks and measures of community complexity that can help inform areas of priority in conservation. This study observed a plant-pollinator network in a secondary forest close to the Río Zuñac Reserve in the eastern Ecuadorian cloud forest to identify assemblages of plants and pollinators and evaluate measures of community complexity, including specialization and nestedness. Flowering plants were identified and observed along a 1.2 km transect, and floral visitors to these …

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Variation Of Carbon Stock Of Boca Del Drago Mangrove Forests Based On Salinity And Seaward Proximity, Fiona Wyrtzen Oct 2023

Variation Of Carbon Stock Of Boca Del Drago Mangrove Forests Based On Salinity And Seaward Proximity, Fiona Wyrtzen

Independent Study Project (ISP) Collection

Mangrove forests, at the intersection of land and sea, are considered one of the most important marine environments for their variety of ecosystem services and their ability to sequester large amounts of carbon in their biomass and adjacent soils. With a changing climate, many of the abiotic and biotic factors influencing mangroves will begin to shift, potentially impacting resilience, growth capacity, and distribution of mangroves worldwide. This study aimed to examine the influence of changing salinity on the carbon stock capacity for Rhizophora mangle and Laguncularia racemosa forests, and the distribution of biomass in each species relative to salinity in …

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Intelligence Versus Inferno: How Artificial Intelligence Can Be Used To Monitor And Manage Wildfires In Europe, Maxwell Feldman Oct 2023

Intelligence Versus Inferno: How Artificial Intelligence Can Be Used To Monitor And Manage Wildfires In Europe, Maxwell Feldman

Independent Study Project (ISP) Collection

Escalating wildfire occurrences in Europe, particularly in the southern Mediterranean region, are presenting significant challenges to socioeconomic, environmental, and ecosystem services. The increasing frequency and severity of these wildfires are straining resources and emphasizing the need for a better understanding of the relationship between suppression capacity and fire behavior in wildfire management. The following research addresses the urgent need for more proactive, knowledge-based, and technologically driven fire management strategies, throughout all four stages of wildfire response – fuel and land management, fire preparedness, fire suppression, and post-fire management. Artificial Intelligence (AI) is becoming increasingly significant in climate change adaptation, especially …

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Patrimonio Cultural, Arqueología, Medio Ambiente Y Economía: ¿Cómo Ha Afectado La Construcción Del Aeropuerto Internacional De Chinchero-Cusco A Las Comunidades Y La Tierra De Chinchero?, Sydney Berenson Oct 2023

Patrimonio Cultural, Arqueología, Medio Ambiente Y Economía: ¿Cómo Ha Afectado La Construcción Del Aeropuerto Internacional De Chinchero-Cusco A Las Comunidades Y La Tierra De Chinchero?, Sydney Berenson

Independent Study Project (ISP) Collection

La urbanización gubernamental ha sido un problema para las poblaciones indígenas, el medio ambiente y la protección del patrimonio cultural durante numerosos años en todo el Perú. Más recientemente, en la pequeña ciudad de Chinchero, ubicada a unos 30 kilómetros al noroeste de Cusco, se está construyendo un nuevo aeropuerto internacional, Aeropuerto Internacional de Chinchero-Cusco (AICC), para reemplazar el actual aeropuerto nacional de Cusco. Chinchero es un importante centro urbano que está conformado por 13 comunidades campesinas que participan en la industria agrícola de la región, además consta con una importante comunidad artesanal, ruinas arqueológicas precolombinas y una gran biodiversidad. …

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The Uses And Limitations Of Citizen Science For Monitoring The Australian Grey Nurse Shark (Carcharias Taurus) Population, Leah Corckran Oct 2023

The Uses And Limitations Of Citizen Science For Monitoring The Australian Grey Nurse Shark (Carcharias Taurus) Population, Leah Corckran

Independent Study Project (ISP) Collection

iNaturalist is a citizen science photographic database, which is an underutilized resource in photographic identification research studies. Grey nurse sharks are critically endangered and there is a lack of knowledge regarding the estimated population size, longevity, and interactions with fisheries of this species off the coasts of Australia. To determine how photos submitted to iNaturalist can be used in Carcharias taurus conservation, the photographs were evaluated on a number of criteria including: location, date, visibility of spot patterns, visible sex characteristics, and visible injuries. In total, 814 photographs of grey nurse sharks were obtained from the iNaturalist database. Only 23.2% …

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Organism Communities On Giant Clam Shells As Compared To The Surrounding Substrate In Reefs Around Lizard Island, Queensland, Gayatri Singla Oct 2023

Organism Communities On Giant Clam Shells As Compared To The Surrounding Substrate In Reefs Around Lizard Island, Queensland, Gayatri Singla

Independent Study Project (ISP) Collection

Coral reef ecosystems are facing destruction at the hands of anthropogenic climate change. Therefore, it is essential that we move to better understand the ecosystem functions of the organisms present in reefs. One such family whose ecosystem function we are unfamiliar with are the giant clams (family Cardiidae). As unique and abundant macrofauna, they have the potential to play an important role in their environment. The goal of our study was to determine how giant clams function as settlement substrata. We conducted 151 observational surveys of epibionts residing on living giant clam shells and of the organism communities in the …

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Lha, Lu, And Shipda: Religious Landscape In A Conservation Area, Luke Stumpfl Oct 2023

Lha, Lu, And Shipda: Religious Landscape In A Conservation Area, Luke Stumpfl

Independent Study Project (ISP) Collection

Living in a political, cultural, and geographic border region between Nepal and Tibet (People’s Republic of China), the families of Tsum Valley face many demands from their sociopolitical, religious, and economic climate. Practicing Tibetan Buddhism, the people uphold a set of rules implemented by the community with leadership from Serap Dorje Drukpa Rinpoche over 100 years ago that prohibits the intentional murder of all animals. Hailed by leaders and scholars as a haven of biodiversity conservation due to this customary-turned- municipal law, Tsum Valley also exists within Manaslu Conservation Area governed by an entity of the federal government of Nepal …

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Flujos De Servicios Ecosistémicos En Un Área Marina Protegida Del Atlántico Sur: Perspectivas Desde El Análisis De La Teoría De Redes, Mitch Porter Oct 2023

Flujos De Servicios Ecosistémicos En Un Área Marina Protegida Del Atlántico Sur: Perspectivas Desde El Análisis De La Teoría De Redes, Mitch Porter

Independent Study Project (ISP) Collection

En cuestiones de gestión de áreas protegidas, los servicios ecosistémicos se tienen cada vez más en cuenta junto con la conservación de la biodiversidad. Sin embargo, las decisiones que se toman sobre la conservación de los servicios ecosistémicos no suelen incluir los posibles efectos en cascada de la pérdida de biodiversidad sobre la provisión de servicios. Los conocimientos de la teoría de redes y los estudios de robustez pueden proporcionar una metodología para evaluar la vulnerabilidad de estos servicios frente la estructura trófica de los ecosistemas que los proveen. A través de una serie de simulaciones de extinción para la …

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Analyzing Human - Nonhuman Primate Conflict Mitigation Techniques In Mto Wa Mbu, Northern Tanzania, Lily Adams Oct 2023

Analyzing Human - Nonhuman Primate Conflict Mitigation Techniques In Mto Wa Mbu, Northern Tanzania, Lily Adams

Independent Study Project (ISP) Collection

Human – non-human primate conflict is particularly crucial due to primates’ high capacity to live among human populations. The study to analyze Human - Nonhuman Primate Conflict Mitigation Techniques, was carried in November 2023 at Mto wa Mbu, Northern Tanzania. To analyze techniques currently being used to mitigate human – non-human primate conflict, this study collected data through semi-structured interviews. Over 87% (n=35) of respondents used multiple mitigation techniques simultaneously. 80% of respondents (n=32) reported using projectiles to ward off foraging primates, 75% of respondents (n=30) reported using loud noises (made either by the voice/body or by manipulating noisemakers), 67.5% …

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Representations And Realities: Misali Island's Biodiversity In Hybrid Narratives, Justin Ross Whitney Oct 2023

Representations And Realities: Misali Island's Biodiversity In Hybrid Narratives, Justin Ross Whitney

Independent Study Project (ISP) Collection

Marine Protected Areas (MPAs) are complex organisms that ebb and flow between strict and unyielding conservation doctrines often at the cost of community engagement. Misali Island is different. Conceived and advocated for by community members, this organism has navigated a tumultuous tenure of environmental degradation, periods of high and low funding, and a looming tourism presence. On top of these challenges has been a growing fishing community attempting to share in the bounty of this shockingly biodiverse setting. This study sorts through the grey space of Misali Island by applying a hybrid narrative that interfaces the marine context of the …

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Analyzing Stress Levels Of Volunteers Hand-Rearing Juvenile Spectacled Flying Foxes (Pteropus Conspicillatus) At The Tolga Bat Hospital, North Queensland, Australia, Olivia Knight Oct 2023

Analyzing Stress Levels Of Volunteers Hand-Rearing Juvenile Spectacled Flying Foxes (Pteropus Conspicillatus) At The Tolga Bat Hospital, North Queensland, Australia, Olivia Knight

Independent Study Project (ISP) Collection

This study, conducted at the Tolga Bat Hospital in North Queensland, Australia, focuses on analyzing the stress levels of volunteers hand-rearing juvenile spectacled flying foxes (Pteropus conspicillatus). Given the endangered status of this species and the intensive care required for their rehabilitation, the research aimed to understand the physical, emotional, and mental well-being of the volunteers engaged in this demanding conservation work. The study was conducted over a five-day period during the peak pupping season in November 2023, utilizing self-administered questionnaires to assess the well-being and stress levels of volunteers both before and after their nursing sessions. The participants, primarily …

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Creating A Framework For An Effective Koala Recovery Center: A Case Study Of Friends Of The Koala, Nsw, Finley Scoular Oct 2023

Creating A Framework For An Effective Koala Recovery Center: A Case Study Of Friends Of The Koala, Nsw, Finley Scoular

Independent Study Project (ISP) Collection

Koala populations in New South Wales, Queensland, and the Australian Capital District are currently faced with factors that threaten their survival. Within one decade, their status has shifted from stable to vulnerable to endangered. The cause of this is attributed to increased exposure to dog attacks, vehicle collisions, diseases, and habitat fragmentation and destruction. The koalas' status of endangered in these territories has illuminated the need for human intervention. This study focuses on the specific form of human intervention that involves the rescue, rehabilitation, and release of wild koalas. Due to the recent koala status change from vulnerable to endangered, …

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Temperate Silvopastures Provide Greater Ecosystem Services Than Conventional Pasture Systems, Helen C.S. Amorim, Amanda Ashworth, Peter L. O'Brien, Andrew L. Thomas, Benjamin R. Runkle, Dirk Philipp Oct 2023

Temperate Silvopastures Provide Greater Ecosystem Services Than Conventional Pasture Systems, Helen C.S. Amorim, Amanda Ashworth, Peter L. O'Brien, Andrew L. Thomas, Benjamin R. Runkle, Dirk Philipp

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Management and design affect systems’ ability to deliver ecosystem services and meet sustainable intensification needs for a growing population. Soil–plant–animal health evaluations at the systems level for conventional and silvopastoral environments are lacking and challenge adoption across temperate regions. Impacts of silvopasture on soil quality, microclimate, cattle heat stress, forage quality and yield, and cattle weight gain were compared to a conventional pasture in the mid-southern US. Here, we illustrate silvopastures have greater soil organic carbon, water content, and overall quality, with lower temperatures (soil and cattle) than conventional pastures. Forage production and cattle weight gains were similar across systems; …

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Tracing And Segmentation Of Molecular Patterns In 3-Dimensional Cryo-Et/Em Density Maps Through Algorithmic Image Processing And Deep Learning-Based Techniques, Salim Sazzed Oct 2023

Tracing And Segmentation Of Molecular Patterns In 3-Dimensional Cryo-Et/Em Density Maps Through Algorithmic Image Processing And Deep Learning-Based Techniques, Salim Sazzed

Computer Science Theses & Dissertations

Understanding the structures of biological macromolecules is highly important as they are closely associated with cellular functionalities. Comprehending the precise organization of actin filaments is crucial because they form the dynamic cytoskeleton, which offers structural support to cells and connects the cell’s interior with its surroundings. However, determining the precise organization of actin filaments is challenging due to the poor quality of cryo-electron tomography (cryo-ET) images, which suffer from low signal-to-noise (SNR) ratios and the presence of missing wedge, as well as diverse shape characteristics of actin filaments. To address these formidable challenges, the primary component of this dissertation focuses …

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Front Matter Oct 2023

Front Matter

The Synapse: Intercollegiate science magazine

No abstract provided.

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