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Articles 10051 - 10080 of 11809
Full-Text Articles in Physical Sciences and Mathematics
Extracting Information From Functional Connectivity Maps Via Function-On-Scalar Regression, Philip T. Reiss, Maarten Mennes, Eva Petkova, Lei Huang, Matthew J. Hoptman, Bharat B. Biswal, Stanley J. Colcombe, Xi-Nian Zuo, Michael P. Milham
Extracting Information From Functional Connectivity Maps Via Function-On-Scalar Regression, Philip T. Reiss, Maarten Mennes, Eva Petkova, Lei Huang, Matthew J. Hoptman, Bharat B. Biswal, Stanley J. Colcombe, Xi-Nian Zuo, Michael P. Milham
Philip T. Reiss
Functional connectivity of an individual human brain is often studied by acquiring a resting state functional magnetic resonance imaging scan, and mapping the correlation of each voxel's BOLD time series with that of a seed region. As large collections of such maps become available, including multisite data sets, there is an increasing need for ways to distill the information in these maps in a readily visualized form. Here we propose a two-step analytic strategy. First, we construct connectivity-distance profiles, which summarize the connectivity of each voxel in the brain as a function of distance from the seed, a functional relationship …
Dna Methylation And Its Association With Prenatal Exposures And Pregnancy Outcomes, Jennifer Straughen
Dna Methylation And Its Association With Prenatal Exposures And Pregnancy Outcomes, Jennifer Straughen
USF Tampa Graduate Theses and Dissertations
Altered DNA methylation may lead to suboptimal fetal programming, increasing the risk of adverse pregnancy outcomes such as small for gestational age (SGA); however, few studies have examined the associations between DNA methylation, prenatal exposures, and fetal outcomes. Cross-sectional data from a larger, ongoing study were used to assess the impact of prenatal smoking on gene specific methylation of umbilical cord blood derived DNA and to investigate the association between gene-specific methylation and risk of SGA. The association between gene-specific DNA methylation and birthweight was also assessed. Maternal and infant covariates were abstracted from medical records, cigarette smoke exposure was …
Evaluation Of Common Inherited Variants In Mitochondrial-Related And Microrna-Related Genes As Novel Risk Factors For Ovarian Cancer, Jennifer Permuth Wey
Evaluation Of Common Inherited Variants In Mitochondrial-Related And Microrna-Related Genes As Novel Risk Factors For Ovarian Cancer, Jennifer Permuth Wey
USF Tampa Graduate Theses and Dissertations
Epithelial ovarian cancer (EOC) is a leading cause of morbidity and mortality among women in the United States, and the etiology is incompletely understood. Common, low penetrant genetic variants such as single nucleotide polymorphisms (SNPs) likely contribute to a significant proportion of EOC. We examined whether SNPs in two understudied yet biologically important types of genes, mitochondrial-related and miRNA-related genes, may contribute to EOC susceptibility using data from a large, homogeneous study population of 1,815 EOC cases and 1,900 controls (frequency-matched on age-group and race/ethnicity) genotyped through stage 1 of an ongoing genome-wide association study. Inter-individual variation in genes involved …
Enhanced Detection Of Groundwater Contamination From A Leaking Waste Disposal Site By Microbial Community Profiles, Paula J. Mouser, Donna M. Rizzo, Gregory K. Druschel, Sergio E. Morales, Nancy Hayden, Patrick O'Grady, Lori Stevens
Enhanced Detection Of Groundwater Contamination From A Leaking Waste Disposal Site By Microbial Community Profiles, Paula J. Mouser, Donna M. Rizzo, Gregory K. Druschel, Sergio E. Morales, Nancy Hayden, Patrick O'Grady, Lori Stevens
College of Engineering and Mathematical Sciences Faculty Publications
Groundwater biogeochemistry is adversely impacted when municipal solid waste leachate, rich in nutrients and anthropogenic compounds, percolates into the subsurface from leaking landfills. Detecting leachate contamination using statistical techniques is challenging because well strategies or analytical techniques may be insufficient for detecting low levels of groundwater contamination. We sampled profiles of the microbial community from monitoring wells surrounding a leaking landfill using terminal restriction fragment length polymorphism (T-RFLP) targeting the 16S rRNA gene. Results show in situ monitoring of bacteria, archaea, and the family Geobacteraceae improves characterization of groundwater quality. Bacterial T-RFLP profiles showed shifts correlated to known gradients of …
Conjugated Quantum Dots Inhibit The Amyloid Β (1–42) Fibrillation Process, Garima Thakur, Miodrag Micic, Yuehai Yang, Wenzhi Li, Dania Movia, Silvia Giordani, Hongzhou Zhou, Roger M. Levlanc
Conjugated Quantum Dots Inhibit The Amyloid Β (1–42) Fibrillation Process, Garima Thakur, Miodrag Micic, Yuehai Yang, Wenzhi Li, Dania Movia, Silvia Giordani, Hongzhou Zhou, Roger M. Levlanc
Department of Physics
Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstrated that the amyloid beta mixed with and conjugated to dihydrolipoic acid- (DHLA) capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5 nm can be used to reduce the fibrillation process. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation. There is a significant change in morphology of fibrils when amyloid β (1–42) (Aβ (1–42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease …
Ua1b1/3 University Lecture Series, Wku Archives
Ua1b1/3 University Lecture Series, Wku Archives
WKU Archives Collection Inventories
Records created by the University Lecture Series committee which invites distinguished and prominent individuals to lecture at the university. The records include correspondence with potential speakers and programs, posters and recordings of lectures.
Ua1b1/2 L.Y. Lancaster Lecture Series, Wku Archives
Ua1b1/2 L.Y. Lancaster Lecture Series, Wku Archives
WKU Archives Collection Inventories
Records regarding the L.Y. Lancaster Lecture Series.
When Curiosity Kills More Than The Cat: The Perils Of Unchecked Scientific Inquiry, Jamie Shannon
When Curiosity Kills More Than The Cat: The Perils Of Unchecked Scientific Inquiry, Jamie Shannon
Pomona Senior Theses
This work analyzes the ecological, physical, emotional and health impacts of the US nuclear testing done in the Marshall Islands in the mid-20th century.
Network Science: Using Information Technology To Enable Collaboration, Arden L. Bement Jr.
Network Science: Using Information Technology To Enable Collaboration, Arden L. Bement Jr.
PPRI Digital Library
No abstract provided.
Conclusions About Niche Expansion In Introduced Impatiens Walleriana Populations Depend On Method Of Analysis, Lisa Mandle, Dan L. Warren, Matthias H. Hoffmann, A. Townsend Peterson, Johanna Schmitt, Eric J. Von Wettberg
Conclusions About Niche Expansion In Introduced Impatiens Walleriana Populations Depend On Method Of Analysis, Lisa Mandle, Dan L. Warren, Matthias H. Hoffmann, A. Townsend Peterson, Johanna Schmitt, Eric J. Von Wettberg
College of Agriculture and Life Sciences Faculty Publications
Determining the degree to which climate niches are conserved across plant species' native and introduced ranges is valuable to developing successful strategies to limit the introduction and spread of invasive plants, and also has important ecological and evolutionary implications. Here, we test whether climate niches differ between native and introduced populations of Impatiens walleriana, globally one of the most popular horticultural species. We use approaches based on both raw climate data associated with occurrence points and ecological niche models (ENMs) developed with Maxent. We include comparisons of climate niche breadth in both geographic and environmental spaces, taking into account differences …
Aflatoxin B1 Albumin Adducts In Plasma And Aflatoxin M1 In Urine Are Associated With Plasma Concentrations Of Vitamins A And E, Francis A. Obuseh, Pauline E. Jolly, Yi Jiang, Faisal M. B. Shuaib, John Waterbor, William O. Ellis, Chandrika J. Piyathilake, Renee A. Desmond, Evans Afriyie-Gyawu, Timothy D. Phillips
Aflatoxin B1 Albumin Adducts In Plasma And Aflatoxin M1 In Urine Are Associated With Plasma Concentrations Of Vitamins A And E, Francis A. Obuseh, Pauline E. Jolly, Yi Jiang, Faisal M. B. Shuaib, John Waterbor, William O. Ellis, Chandrika J. Piyathilake, Renee A. Desmond, Evans Afriyie-Gyawu, Timothy D. Phillips
Evans Afriyie-Gyawu
Background: Although aflatoxin exposure has been shown to be associated with micronutrient deficiency in animals, there are few investigations on the effects of aflatoxin exposure on micronutrient metabolism in humans.
Objective: To examine the relationship between aflatoxin B1 (AFB1) albumin adducts (AF-ALB) in plasma and the aflatoxin M1 (AFM1) metabolite in urine and plasma concentrations of retinol (vitamin A) and α-tocopherol (vitamin E) in Ghanaians.
Methods: A cross-sectional study of 147 adult participants was conducted. Blood and urine samples were tested for aflatoxin and vitamins A and E levels.
Results: Multivariable analysis showed that participants with high AF-ALB (≥ 0.80 …
Effects Of Acculturation On Hiv/Aids Sexual Risk Behaviors Among Asian And Pacific Islander (Api) Women, Margaret Cabotage Salud
Effects Of Acculturation On Hiv/Aids Sexual Risk Behaviors Among Asian And Pacific Islander (Api) Women, Margaret Cabotage Salud
Loma Linda University Electronic Theses, Dissertations & Projects
Background. In the US women are the fastest growing group for sexually transmitted infections (STIs), including HIV and AIDS. In addition, the estimated AIDS cases among female adults and adolescents, aged 13-19, increased from 7% in 1985 to approximately 26% in 2002. Most infections occur by heterosexual transmission with 53% occurring through contact with a high-risk sexual partner. While overall HIV/AIDS rates in the Asian Pacific Islander (API) community remain low, they are rising and HIV testing rates, one of the major prevention strategies for HIV, are lower than that of other populations. Furthermore, very little is known about APIs …
Spatial Epidemiology Of Birth Defects In The United States And The State Of Utah Using Geographic Information Systems And Spatial Statistics, Samson Y. Gebreab
Spatial Epidemiology Of Birth Defects In The United States And The State Of Utah Using Geographic Information Systems And Spatial Statistics, Samson Y. Gebreab
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Oral clefts are the most common form of birth defects in the United States (US) and the State of Utah has among the highest prevalence of oral clefts in the nation. The overall objective of this dissertation was to examine the spatial distribution of oral clefts and their linkage with a broad range of demographic, behavioral, social, economic, and environmental risk factors through the application of Geographic Information Systems (GIS) and spatial statistics. Using innovative linked micromaps plots, we investigated the geographic patterns of oral clefts occurrence from 1998 to 2002 and their relationships with maternal smoking rates and proportion …
Toward Effective Concept Representation In Decision Support To Improve Patient Safety, Tze-Yun Leong
Toward Effective Concept Representation In Decision Support To Improve Patient Safety, Tze-Yun Leong
Research Collection School Of Computing and Information Systems
Patient safety is an emerging, major health care discipline with significance accentuated in the influential Institute of Medicine (IOM) reports in the United States “To Err is Human” and “Crossing the Quality Chasm”. These reports highlighted the danger and prevalence of medical errors and preventable adverse events, explained the three main sources of system-related, human factors-related and cognitive-related errors, and recommended the use of information and decision support technologies to help alleviate the problem. A number of studies and reports from all over the world with similar findings have since followed, culminating in the 55th World Health Assembly Resolution on …
Development And Validation Of A Rapid Multi-Class Method For The Confirmation Of Fourteen Prohibited Medicinal Additives In Pig And Poultry Compound Feed By Liquid Chromatography Tandem Mass Spectrometry, Mark Cronly, Patrice Behan, Barry Foley, Liam Regan, Marella Gallagher, Sean Earley, Paula Shearan, Edward Malone
Development And Validation Of A Rapid Multi-Class Method For The Confirmation Of Fourteen Prohibited Medicinal Additives In Pig And Poultry Compound Feed By Liquid Chromatography Tandem Mass Spectrometry, Mark Cronly, Patrice Behan, Barry Foley, Liam Regan, Marella Gallagher, Sean Earley, Paula Shearan, Edward Malone
Articles
A confirmatory method has been developed to allow for the analysis of fourteen prohibited medicinal additives in pig and poultry compound feed. These compounds are prohibited for use as feed additives although some are still authorised for use in medicated feed. Feed samples are extracted by acetonitrile with addition of sodium sulphate. The extracts undergo a hexane wash to aid with sample purification. The extracts are then evaporated to dryness and reconstituted in initial mobile phase. The samples undergo an ultracentrifugation step prior to injection onto the LC-MS/MS system and are analysed in a run time of 26 minutes. The …
The Determinants Of Colorectal Cancer Survival Disparities In Nevada, Lucas N. Wassira
The Determinants Of Colorectal Cancer Survival Disparities In Nevada, Lucas N. Wassira
UNLV Theses, Dissertations, Professional Papers, and Capstones
Different population groups across Nevada and throughout the United States suffer disproportionately from colorectal cancer and its after-effects. Overcoming cancer health disparities is important for lessening the burden of cancer. There has been an overall decline in the incidence of and mortality from colorectal cancer (CRC). This is likely due, in part, to the increasing use of screening procedures such as Fecal Occult Blood Test (FOBT) and/or endoscopy, which can reduce the risk of CRC mortality by fifty percent. Nevertheless, screening procedures are routinely used by only fifty percent of Americans aged fifty years and older. Despite overall mortality decreasing …
Coronary Heart Disease Mortality And Long-Term Exposure To Ambient Particulate Air Pollutants In Elderly Nonsmoking California Residents, Lie Hong Chen
Loma Linda University Electronic Theses, Dissertations & Projects
The purpose of this study is to assess the effect of long-term concentrations of ambient PM on risks of all causes, cardiopulmonary, coronary heart disease (CHD), total cancer, and any mention of nonmalignant respiratory disease (NMRD) mortality.
The health effects of long-term ambient air pollution have been studied with up to 30 years of follow-up in the AHSMOG cohort, a cohort of 6,338 nonsmoking white California adults. Monthly concentrations of ambient air pollutants [particulate matter(PMio), Ozone (O3), sulfur dioxide (SO2), nitrogen dioxide (NO2) or particulate matter
In the AHSMOG cohort, each increment of 10 |ig/m3 in PMio in two-pollutant models …
Influence Of Sex On Long-Term Outcomes After Percutaneous Coronary Intervention With The Paclitaxel-Eluting Coronary Stent: Results Of The "Taxus Woman" Analysis, Ghada W. Mikhail Md, Robert T. Gerber Md, Phd, David A. Cox Md, Stephen G. Ellis Md, John M. Lasala Md, Phd, John A. Ormiston Mbchb, Gregg W. Stone Md, Mark A. Turco Md, Anita A. Joshi Phd, Donald S. Baim Md, Antonio Colombo Md
Influence Of Sex On Long-Term Outcomes After Percutaneous Coronary Intervention With The Paclitaxel-Eluting Coronary Stent: Results Of The "Taxus Woman" Analysis, Ghada W. Mikhail Md, Robert T. Gerber Md, Phd, David A. Cox Md, Stephen G. Ellis Md, John M. Lasala Md, Phd, John A. Ormiston Mbchb, Gregg W. Stone Md, Mark A. Turco Md, Anita A. Joshi Phd, Donald S. Baim Md, Antonio Colombo Md
Department of Medicine
No abstract provided.
New Tools For Monitoring Gamma Camera Uniformity, Brad K. Lofton
New Tools For Monitoring Gamma Camera Uniformity, Brad K. Lofton
Dissertations & Theses (Open Access)
Detector uniformity is a fundamental performance characteristic of all modern gamma camera systems, and ensuring a stable, uniform detector response is critical for maintaining clinical images that are free of artifact. For these reasons, the assessment of detector uniformity is one of the most common activities associated with a successful clinical quality assurance program in gamma camera imaging. The evaluation of this parameter, however, is often unclear because it is highly dependent upon acquisition conditions, reviewer expertise, and the application of somewhat arbitrary limits that do not characterize the spatial location of the non-uniformities. Furthermore, as the goal of any …
Minimum Description Length And Empirical Bayes Methods Of Identifying Snps Associated With Disease, Ye Yang, David R. Bickel
Minimum Description Length And Empirical Bayes Methods Of Identifying Snps Associated With Disease, Ye Yang, David R. Bickel
COBRA Preprint Series
The goal of determining which of hundreds of thousands of SNPs are associated with disease poses one of the most challenging multiple testing problems. Using the empirical Bayes approach, the local false discovery rate (LFDR) estimated using popular semiparametric models has enjoyed success in simultaneous inference. However, the estimated LFDR can be biased because the semiparametric approach tends to overestimate the proportion of the non-associated single nucleotide polymorphisms (SNPs). One of the negative consequences is that, like conventional p-values, such LFDR estimates cannot quantify the amount of information in the data that favors the null hypothesis of no disease-association.
We …
Agenda: 2010 World Energy Justice Conference: Emerging Solutions For The Energy Poor: Technological, Entrepreneurial And Institutional Challenges, University Of Colorado Boulder. Center For Energy & Environmental Security, Colorado Journal Of International Environmental Law And Policy
Agenda: 2010 World Energy Justice Conference: Emerging Solutions For The Energy Poor: Technological, Entrepreneurial And Institutional Challenges, University Of Colorado Boulder. Center For Energy & Environmental Security, Colorado Journal Of International Environmental Law And Policy
2010 World Energy Justice Conference (November 5)
This conference is a sequel to the 2009 World Energy Justice Conference (WEJC 2009) which began examining ways of mainstreaming safe, clean, and efficient energy for the world's Energy Poor (EP). The EP number two and a half billion people living on less than $1-2 a day who have no access to modern energy services. WEJC 2010 more fully develops these themes. WEJC 2010 will explore how the next round of global warming meetings in Cancun could design new flexibility mechanisms that give credits, for example, for the reduction of black carbon by the adoption of cookstoves, and embrace small …
Endogenous Sirnas And Noncoding Rna-Derived Small Rnas Are Expressed In Adult Mouse Hippocampus And Are Up-Regulated In Olfactory Discrimination Training., Neil Smalheiser, G Lugli, Jyothi Thimmapuram, E.H. Cook, J Larson
Endogenous Sirnas And Noncoding Rna-Derived Small Rnas Are Expressed In Adult Mouse Hippocampus And Are Up-Regulated In Olfactory Discrimination Training., Neil Smalheiser, G Lugli, Jyothi Thimmapuram, E.H. Cook, J Larson
Cyber Center Publications
We previously proposed that endogenous siRNAs may regulate synaptic plasticity and long-term gene expression in the mammalian brain. Here, a hippocampal-dependent task was employed in which adult mice were trained to execute a nose-poke in a port containing one of two simultaneously present odors in order to obtain a reward. Mice demonstrating olfactory discrimination training were compared to pseudo-training and nose-poke control groups; size-selected hippocampal RNA was subjected to Illumina deep sequencing. Sequences that aligned uniquely and exactly to the genome without uncertain nucleotide assignments, within exons or introns of MGI annotated genes, were examined further. The data confirm that …
Nutrient Enrichment Enhances Hidden Differences In Phenotype To Drive A Cryptic Plant Invasion, Christine Holdredge, Mark D. Bertness, Eric Von Wettberg, Brian R. Silliman
Nutrient Enrichment Enhances Hidden Differences In Phenotype To Drive A Cryptic Plant Invasion, Christine Holdredge, Mark D. Bertness, Eric Von Wettberg, Brian R. Silliman
College of Agriculture and Life Sciences Faculty Publications
Many mechanisms of invasive species success have been elucidated, but those driving cryptic invasions of non-native genotypes remain least understood. In one of the most successful cryptic plant invasions in North America, we investigate the mechanisms underlying the displacement of native Phragmites australis by its Eurasian counterpart. Since invasive Phragmites' populations have been especially prolific along eutrophic shorelines, we conducted a two-year field experiment involving native and invasive genotypes that manipulated nutrient level and competitor identity (inter- and intra-genotypic competition) to assess their relative importance in driving the loss of native Phragmites. Inter-genotypic competition suppressed aboveground biomass of both native …
A Novel Totivirus And Piscine Reovirus (Prv) In Atlantic Salmon (Salmo Salar) With Cardiomyopathy Syndrome (Cms), Torstein Tengs
A Novel Totivirus And Piscine Reovirus (Prv) In Atlantic Salmon (Salmo Salar) With Cardiomyopathy Syndrome (Cms), Torstein Tengs
Dr. Torstein Tengs
BACKGROUNDCardiomyopathy syndrome (CMS) is a severe disease affecting large farmed Atlantic salmon. Mortality often appears without prior clinical signs, typically shortly prior to slaughter. We recently reported the finding and the complete genomic sequence of a novel piscine reovirus (PRV), which is associated with another cardiac disease in Atlantic salmon; heart and skeletal muscle inflammation (HSMI). In the present work we have studied whether PRV or other infectious agents may be involved in the etiology of CMS.RESULTSUsing high throughput sequencing on heart samples from natural outbreaks of CMS and from fish experimentally challenged with material from fish diagnosed with CMS …
Solar Radiation Damage To Human Skin Mitochondria, Luciene Zanchetta
Solar Radiation Damage To Human Skin Mitochondria, Luciene Zanchetta
Doctoral
The central objective of this study was to assess solar radiation-induced changes in cellular function, mitochondrial function and mitochondrial DNA to further investigate the role of these energy-dedicated and metabolically essential organelles in the response to the main environmental stressor associated with skin cancer initiation. An in vitro approach was chosen employing the human malignant melanoma (A375) and human amelanotic melanoma (C32) cells and the human spontaneously immortalized keratinocytes (HaCaT). A Q-Sun Solar Simulator was used to expose cells to low-level simulated solar radiation (SSR) as it provides a mimic of solar radiation that is environmentally relevant in the UV …
Endothelial Cell Capture Of Heparin-Binding Growth Factors Under Flow, Bing Zhao, Changjiang Zhang, Kimberly Forsten-Williams, Jun Zhang, Michael Fannon
Endothelial Cell Capture Of Heparin-Binding Growth Factors Under Flow, Bing Zhao, Changjiang Zhang, Kimberly Forsten-Williams, Jun Zhang, Michael Fannon
Ophthalmology and Visual Science Faculty Publications
Circulation is an important delivery method for both natural and synthetic molecules, but microenvironment interactions, regulated by endothelial cells and critical to the molecule's fate, are difficult to interpret using traditional approaches. In this work, we analyzed and predicted growth factor capture under flow using computer modeling and a three-dimensional experimental approach that includes pertinent circulation characteristics such as pulsatile flow, competing binding interactions, and limited bioavailability. An understanding of the controlling features of this process was desired. The experimental module consisted of a bioreactor with synthetic endothelial-lined hollow fibers under flow. The physical design of the system was incorporated …
Determining Optimal Storage Arrangements For Open Access Data Sets, As For Nsf Data Management Plan Requirements, David B. Lowe
Determining Optimal Storage Arrangements For Open Access Data Sets, As For Nsf Data Management Plan Requirements, David B. Lowe
Published Works
Document is a proposed draft of a decision tree to be used in determining what approach to take for making data available in order to comply with open access requirements for data management, as per National Science Foundation requirements.
Is Philosophy Dead? Far From It, Charles Weijer
Rotman Institute Opening, Joseph Rotman, Janice Deakin, Jane Maienschein, Charles Weijer, Philip Kitcher
Rotman Institute Opening, Joseph Rotman, Janice Deakin, Jane Maienschein, Charles Weijer, Philip Kitcher
Charles Weijer
No abstract provided.
Comparison Of Bacteroides Human Markers For Pollution Diagnostics In Recreational Waters, Asli Aslan, Joan B. Rose
Comparison Of Bacteroides Human Markers For Pollution Diagnostics In Recreational Waters, Asli Aslan, Joan B. Rose
Environmental Health Sciences Faculty Presentations
This presentation was given during the Great Lakes Beach Association Annual Conference.