Physical Sciences and Mathematics Commons^™

Dynamic Light Scattering Optical Coherence Tomography To Probe Motion Of Subcellular Scatterers., Nico J J Arezza, Marjan Razani, Michael C Kolios

Medical Biophysics Publications

Optical coherence tomography (OCT) is used to provide anatomical information of biological systems but can also provide functional information by characterizing the motion of intracellular structures. Dynamic light scattering OCT was performed on intact, control MCF-7 breast cancer cells and cells either treated with paclitaxel to induce apoptosis or deprived of nutrients to induce oncosis. Autocorrelations (ACs) of the temporal fluctuations of OCT intensity signals demonstrate a significant decrease in decorrelation time after 24 h in both the paclitaxel-treated and nutrient-deprived cell groups but no significant differences between the two groups. The acquired ACs were then used as input for …

Bench Tracker: Improving Actionable Insights In Smartwatch Fitness Application By Increasing Usability Through Simplification, Chris Campanelli

Faculty of Applied Science and Technology - Exceptional Student Work, Applied Computing Theses

This thesis describes a smartwatch solution, called Bench Tracker for fitness monitoring using Apple Watches and Apple iPhone devices. The system involves a mobile based application that allows users to track and monitor bench press workouts in real-time to create actionable insights. By creating actionable insights on a smartwatch application, and improving the application’s usability through simplification, users agreed they would use the fitness application created that specifically tracked bench presses. A leading fitness app was used as the comparator, and it was discovered that users were undecided if they would use this app for bench press tracking. This paper …

Security Analysis Of A Large-Scale Concurrent Data Anonymous Batch Verification Scheme For Mobile Healthcare Crowd Sensing, Yinghui Zhang, Jiangang Shu, Ximeng Liu, Jin Li, Dong Zheng

Research Collection School Of Computing and Information Systems

As an important application of the Internet of Things (IoT) technologies, mobile healthcare crowd sensing (MHCS) still has challenging issues, such as privacy protection and efficiency. Quite recently in IEEE Internet of Things Journal (DOI: 10.1109/JIOT.2018.2828463), Liu et al. proposed a large-scale concurrent data anonymous batch verification scheme for mobile healthcare crowd sensing, claiming to provide batch authentication, non-repudiation, and anonymity. However, after a close look at the scheme, we point out that the scheme suffers two types of signature forgery attacks and hence fails to achieve the claimed security properties. In addition, a reasonable and rigorous probability analysis indicates …

Deep Learning Based Medical Image Analysis With Limited Data, Jiaxing Tan

Dissertations, Theses, and Capstone Projects

Deep Learning Methods have shown its great effort in the area of Computer Vision. However, when solving the problems of medical imaging, deep learning’s power is confined by limited data available. We present a series of novel methodologies for solving medical imaging analysis problems with limited Computed tomography (CT) scans available. Our method, based on deep learning, with different strategies, including using Generative Adversar- ial Networks, two-stage training, infusing the expert knowledge, voting based or converting to other space, solves the data set limitation issue for the cur- rent medical imaging problems, specifically cancer detection and diagnosis, and shows very …

Synthesis, Biological Evaluation And Molecular Modeling Studies Of Novel Chromone/Aza-Chromone Fused Α-Aminophosphonates As Src Kinase Inhibitors, S. Bapat, N. Viswanadh, M. Mujahid, Amir Nasrolahi Shirazi, Rakesh Tiwari, Keykavous Parang, M. Karthikeyan, M. Muthukrishnan, Renu Vyas

Pharmacy Faculty Articles and Research

A series of novel chromone/aza-chromone fused α-aminophosphonate derivatives were synthesized in good yields using silica chloride as the catalyst. All the synthesized compounds were tested for their c-Src kinase inhibitory activity. Aza-chromone compound showed Src kinase inhibition with an IC50 value of 15.8 µM. The compounds were subjected to molecular docking and dynamics simulations to study the atomic level interactions with an unphosphorylated proto-oncogenic tyrosine protein kinase Src (PDB code 1Y57) as well as phosphorylated tyrosine protein kinase Src (PDB code 2H8H). Docking and molecular dynamic results revealed phosphorylated Src tyrosine kinase protein better results than unphosphorylated tyrosine Src kinase …

Use Of Novel Anthropomorphic Breast Ultrasound Phantoms For Radiology Resident Education, Jacinta Browne, Chris Gu, Robert Fazzio, Andrew Fagan, Donald Tradup, Nicholas Hangiandreou

Articles

Purpose: This study evaluated the training and assessment role of anthropomorphic breast ultrasound phantoms which simulated both the morphological and sonographic characteristics of breast tissue, including lesions, in a group of radiology residents at a large academic medical center. Methods: This was a prospective study involving 9 residents across all years (2^nd–4^th year) of a radiology residency program. Baseline assessments of all residents ability to detect and characterize lesions in P-I were carried out, followed by a two-hour teaching session on the same phantom. All residents underwent a post-training, final assessment on P-II to evaluate changes in …

Binti Kasar Kecil Seperti Kutil Bisa Tumbuh Di Penis Dan Anus Karena Beberapa Sebab Ini, Alif Nur

Alif Nur

Cara Cepat Merontokan Daging Tumbuh Kecil Kasar Seperti Kutil Di Penis Dan Anus, Alif Nur

Alif Nur

Obat Bintik Kasar Kecil Seperti Kutil Di Anus Dan Penis Yang Jualdi Apotik, Alif Nur

Alif Nur

Bagaimana Cara Mengobati Luka Lecet Pada Penis Seperti Sariawan, Alif Nur

Alif Nur

Comforting With Mathematics: A Case Study, Michael J. Goldstein

Journal of Humanistic Mathematics

Death by suicide often leaves behind grieving family members with unanswered questions. Of these concerns, fear that their loved one suffered or felt regret is common. When the method of suicide was jumping from height, that answer can easily be determined using basic kinematics. Despite the perception that mathematics is a cold, calculating field, it can provide a clear, definitive answer and comfort those left behind.

Does Household Capital Mediate The Uptake Of Agricultural Land, Crop, And Livestock Adaptations? Evidence From The Indo-Gangetic Plains (India), Sameer H. Shah, Courtney Hammond Wagner, Udita Sanga, Hogeun Park, Lia Helena Monteiro De Lima Demange, Carolina Gueiros, Meredith T. Niles

College of Agriculture and Life Sciences Faculty Publications

Farmers in the Indo-Gangetic Plains produce much of the wheat and rice grown in India. However, food production and millions of farm-based livelihoods in this region will continue to be adversely affected by hydro-climatic change and variation, reduced land productivity, and declining groundwater levels. Thus, agricultural adaptations are essential for protecting and improving upon intersecting goals of food security, poverty alleviation, and wellbeing. Household “capital” (e.g., natural, human, financial, physical, and social) is commonly cited as an indicator of livelihood adaptability and innovation. We develop a series of mediated structural equation models to empirically evaluate the validity of capital as …

Evaluation Of An Educational Campaign To Improve The Conscious Consumption Of Recreationally Caught Fish, Corey A. Krabbenhoft, Susan Manente, Donna R. Kashian

Environmental Science and Geology Faculty Research Publications

Consumption guidelines are a common way of improving conscious consumption behaviors in areas where game fish are known to contain contaminants. However, guideline information can be difficult to distribute, and effectiveness difficult to measure. To increase the distribution and effectiveness of guideline information for the Detroit River, an educational campaign was launched in 2010, which included distribution of pamphlets with consumption information, posting of permanent signs at popular fishing locations, and hiring River Walkers to personally communicate with anglers. In 2013 and 2015, we conducted in-person surveys of active shoreline anglers to determine the effectiveness of education and outreach efforts. …

Opioids And Cerebral Physiology In The Acute Management Of Traumatic Brain Injury: A Systematic Review, Joshua Weiner, Amanda Mcintyre, Shannon Janzen, Magdalena Mirkowski, Heather M. Mackenzie, Robert Teasell

Epidemiology and Biostatistics Publications

Background: Following traumatic brain injury (TBI), optimization of cerebral physiology is recommended to promote more favourable patient outcomes. Accompanying pain and agitation are commonly treated with sedative and analgesic agents, such as opioids. However, the impact of opioids on certain aspects of cerebral physiology is not well established.

Objective: To conduct a systematic review of the evidence on the effect of opioids on cerebral physiology in TBI during acute care.

Methods: A comprehensive literature search was conducted in five electronic databases for articles published in English up to November 2017. Studies were included if: (1) the study sample was human …

Obat Wasir Alami Terbaik Saat Ini, 100% Terbuat Dari Bahan Herbal Alami, Herbal Keramat

Herbal Keramat

• Terlalu banyak duduk.
• Keturunan wasir.
• Kehamilan ibu hamil yang diakibatkan perubahan hormon.
• Diare yang menahun.
• Hubungan seks yang tidak lazim.
• Penyakit yang membuat mengejan penderita.
• Sembelit / konstipasi / obsitpasi menahun.
• Penekanan kembali aliran darah vena, dll.

Overview Of The Biocreative Vi Precision Medicine Track: Mining Protein Interactions And Mutations For Precision Medicine, Rezarta Islamaj Doğan, Sun Kim, Andrew Chatr-Aryamontri, Chih-Hsuan Wei, Donald C. Comeau, Rui Antunes, Sérgio Matos, Qingyu Chen, Aparna Elangovan, Nagesh C. Panyam, Karin Verspoor, Hongfang Liu, Yanshan Wang, Zhuang Liu, Berna Altınel, Zehra Melce Hüsünbeyi, Arzucan Özgür, Aris Fergadis, Chen-Kai Wang, Hong-Jie Dai, Tung Tran, Ramakanth Kavuluru, Ling Luo, Albert Steppi, Jinfeng Zhang, Jinchan Qu, Zhiyong Lu

Computer Science Faculty Publications

The Precision Medicine Initiative is a multicenter effort aiming at formulating personalized treatments leveraging on individual patient data (clinical, genome sequence and functional genomic data) together with the information in large knowledge bases (KBs) that integrate genome annotation, disease association studies, electronic health records and other data types. The biomedical literature provides a rich foundation for populating these KBs, reporting genetic and molecular interactions that provide the scaffold for the cellular regulatory systems and detailing the influence of genetic variants in these interactions. The goal of BioCreative VI Precision Medicine Track was to extract this particular type of information and …

Obat Vertigo Paling Ampuh, Herbal Keramat

Herbal Keramat

Obat Sinusitis Terampuh Dan Berlegalitas Resmi, User Id

Rizky Herbal

Obat Kanker Nasofaring Terbukti Ampuh Dan Aman Tanpa Efek Samping, User Id

Rizky Herbal

Amino Alkynylisoquinoline And Alkynylnaphthyridine Compounds Potently Inhibit Acute Myeloid Leukemia Proliferation In Mice, N Naganna, Clement Opuku-Temeng, Eun Yong Choi, Elizabeth Larocque, Elizabeth T. Chang, Brandon A. Carter-Cooper, Modi Wang, Sandra E. Torregrossa-Allen, Bennett D. Elzey, Rena G. Lapidus, Herman Sintim

Department of Chemistry Faculty Publications

B

ackground: Acute myeloid leukemia (AML) remains one of the most lethal, rarely cured cancers, despite decades of active development of AML therapeutics. Currently, the 5-year survival of AML patients is about 30% and for elderly patients, the rate drops to b10%. About 30% of AML patients harbor an activating mutation in the tyrosine kinase domain (TKD) of Fms-Like Tyrosine kinase 3 (FLT3) or a FLT3 internal tandem duplication (FLT3-ITD). In- hibitors of FLT3, such as Rydapt that was recently approved by the FDA, have shown good initial response but pa- tients often relapse due to secondary mutations in the …

The Santa Clara, 2019-01-24, Santa Clara University

The Santa Clara

No abstract provided.

Obat Benjolan Di Vagina Yang Sudah Terbukti Ampuh Dan Aman Tanpa Efek Samping, User Id

Rizky Herbal

The Santa Clara, 2019-02-21, Santa Clara University

The Santa Clara

No abstract provided.

Obat Vitiligo Super Ampuh Dijamin Sembuh Permanen, Hanifathu Rizkiyah

Herbal Keramat

Obat Luka Hitam Pada Telapak Kaki, User Id

Rizky Herbal

Obat Miom Yang Sudah Terbukti Ampuh Dan Aman Tanpa Efek Samping, Hanifathu Rizkiyah

Herbal Keramat

• Subserosa—jenis miom ini tumbuh di dalam rahim dan menyebar ke bagian luar serviks.
• Intramural—jenis miom ini hanya tumbuh di dalam rahim, yang mungkin memperbesar ukuran rahim.
• Submukosa—jenis miom ini berkembang di dalam lapisan rahim, yang berarti dapat mempengaruhi siklus menstruasi, sehingga mengakibatkan kemandulan dan keguguran.
• Pedunculated miom—jenis miom ini terhubung ke luar atau dalam rahim melalui sebuah tangkai kecil.

Gene Co-Expression Networks Analysis Reveal Novel Molecular Endotypes In Alpha-1 Antitrypsin Deficiency, Jen-Hwa Chu, Wenlan Zang

Yale Day of Data

Rationale:Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that predisposes to early onset pulmonary emphysema and airways obstruction. The exact mechanism through which AATD leads to lung disease is incompletely understood.

Objectives: To investigate the effect of AAT genotype and augmentation therapy on bronchoalveolar lavage (BAL) and peripheral blood mononuclear cells (PBMC) transcriptome, while examining the link between gene expression profiles, and clinical features of AATD.

Methods: We performed RNA-Seq on RNA extracted from BAL and PBMC on samples obtained from 89 AATD patients enrolled in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study. Differential …

Non-Invasive Analysis Of The Sputum Transcriptome Discriminates Clinical Phenotypes Of Asthma, Xiting Yan

Yale Day of Data

Whole transcriptome wide gene expression profiles in the sputum and circulation from 100 asthma patients were measured using the Affymetrix HuGene 1.0ST arrays. Unsupervised clustering analysis based on pathways from KEGG were used to identify TEA clusters of patients from the sputum gene expression profiles. The identified TEA clusters have significantly different pre-bronchodilator FEV1, bronchodilator responsiveness, exhaled nitric oxide levels, history of hospitalization for asthma and history of intubation. Evaluation of TEA clusters in children from Asthma BRIDGE cohort confirmed the identified differences in intubation and hospitalization. Furthermore, evaluation of the TH2 gene signatures suggested a much lower prevalence of …

The Santa Clara, 2019-01-17, Santa Clara University

The Santa Clara

No abstract provided.

Obat Bells Palsy Yang Sudah Terbukti Ampuh Dan Aman Bebas Efek Samping, User Id

Rizky Herbal

• Herpes kelamin (herpes simplex)
• Cacar air dan sirap (herpes zoster)
• Monosit (Epstein-Barr)
• Penyakit pernapasan …