Physical Sciences and Mathematics Commons^™

Development Of Innovative Stationary Phases For Chiral And Protein Separations In Open Tubular Capillary Electrochromatography, Leonard Moore, Jr.

LSU Doctoral Dissertations

Protein biomarkers in bodily fluids can lead to an indication of the onset of a disease. Due to low abundance of the biomarker at early stages of the disease and other protein interferences, detection may be challenging. Therefore, in order to achieve more selective protein separations, the development of a novel stationary phase has been investigated. Moreover, novel methods to apply polysaccharides as stationary phases were developed for protein separations as well as chiral separations. The initial discussions in this dissertation commences with the use of novel zwitterionic lysine-based molecular micelles as a coating for open tubular capillary electrochromatography (OT-CEC) …

A New Model For Coalition Formation Games, Alfred Samman

LSU Doctoral Dissertations

We present two broad categories of games, namely, group matching games and bottleneck routing games on grids. Borrowing ideas from coalition formation games, we introduce a new category of games which we call group matching games. We investigate how these games perform when agents are allowed to make selfish decisions that increase their individual payoffs versus when agents act towards the social benefit of the game as a whole. The Price of Anarchy (PoA) and Price of Stability (PoS) metrics are used to quantify these comparisons. We show that the PoA for a group matching game is at most kα …

Syntheses And Characterization Of Water-Soluble Phythalocyanines For Diagnosis And Treatment Of Cancer, Benson Getenga Ongarora

LSU Doctoral Dissertations

Ongarora, Benson Getenga, B.S., Moi University, 2005 Doctor of Philosophy, Fall Commencement, 2012 Major: Chemistry Syntheses and Characterization of Water-Soluble Phthalocyanines for Diagnosis and Treatment of Cancer Dissertation directed by Professor M.Graҫa H. Vicente Pages in dissertation, xi. Words in abstract, 251. ABSTRACT Chapter 1 describes the general properties of phthalocyanines, synthesis of metallo-phthalocyanines, their photophysical features and their uses. The concepts of PDT and targeted therapeutics are also introduced. Chapter 2 describes the syntheses, characterization, photophysical studies and biological evaluation of cationic phthalocyanines. The trimethylaminophenoxy substituted phthalocyanines were synthesized through statistical condensation method, which gave a statistical mixture of …

An Evaluation Of Alternative Approaches For Simulating Animal Movement In Spatially-Explicit Individual-Based Models, Katherine Shepard Watkins

LSU Doctoral Dissertations

Simulating animal movement in spatially-explicit individual-based models (IBMs) is both challenging and critically important to accurately estimating population dynamics. I compared four distinct movement approaches or sub-models (restricted-area search, kinesis, event-based, and run and tumble) in a series of simulation experiments. I used an IBM loosely based on a small pelagic fish that simulated growth, mortality, and movement of a cohort on a 2-dimensional grid. First, I tested the sub-models calibrated (i.e., trained) with a genetic algorithm in one set of environmental conditions in three other novel environments. The sub-models performed well, except restricted-area search and event-based that needed to …

Some Tracking Problems For Aerospace Models With Input Constraints, Aleksandra Gruszka

LSU Doctoral Dissertations

We study tracking controller design problems for key models of planar vertical takeoff and landing (PVTOL) aircraft and unmanned air vehicles (UAVs). The novelty of our PVTOL work is the global boundedness of our controllers in the decoupled coordinates, the positive uniform lower bound on the thrust controller, the applicability of our work to cases where the velocity measurements may not be available, the uniform global asymptotic stability and uniform local exponential stability of our closed loop tracking dynamics, the generality of our class of trackable reference trajectories, and the input-to-state stability of the controller performance under actuator errors of …

High-Throughput Sperm Cryopreservation Of Aquatic Species, E Hu

LSU Doctoral Dissertations

The goal of this dissertation was to integrate multiple disciplines for application of high-throughput sperm cryopreservation to aquatic species. The blue catfish Ictalurus furcatus was selected for research due to its role in production of hybrid catfish with eggs from channel catfish Ictalurus punctatus. A high-throughput cryopreservation pathway was developed by systematically evaluating each process factor and using automated processing systems. Large quantities of cryopreserved sperm produced from this protocol were evaluated in commercial-scale hatcheries in cooperation with aquaculture producers. To develop production for commercial requirements, quality characteristics of materials and products were identified and recorded during processing and analyzed …

Greenhouse Gas Emissions And Nutrients Dynamics In Restored Wetlands Of The Mississippi River Basin, Christopher Lundberg

LSU Doctoral Dissertations

Greenhouse gases were sampled during spring and summer months in 2010 and 2011 at two sites in the Mississippi River Basin: a riparian forested wetland under restored flood pulsing near Memphis, TN and a coastal estuarine marsh complex impacted by a river diversion at Caernarvon, LA. Mean methane fluxes at Caernarvon (-0.09 g CH4-C m-2 d-1) were lower than those at Memphis (0.53 g CH4-C m-2 d-1), and did not differ between seasons. Nitrous oxide fluxes were generally below detection limits. Fluxes were uncorrelated with water depth, soil temperature, and ambient air temperature, though sampling occurred over a narrow range …

Geometrical And Electronic Structure Of Metal Oxide Nanoparticles On Silica And Alumina, Udaya Indike Rodrigo

LSU Doctoral Dissertations

Recent studies demonstrated nanometer-scale combustion-generated nanoparticles cause demonstrable health effects. It is essential to understand the chemical characteristics of these nanoparticles. Since combustion-generated nanoparticles arise in complex mixtures, we employed a dendrimeric method to generate simpler, more reproducible nanoparticles, which were tethered to fumed silica and alumina to provide surrogates for fly ash. We collected XANES and EXAFS data, which are useful for characterizing disordered mixtures where the metal is a minor component. The effect of particle size on structural properties was studied with copper oxide nanoparticles on fumed silica. XANES data demonstrated copper atoms in the nanoparticles are present …

Fabrication, Analysis, Application, And Characterization Of Core-Containing Microparticles And Hydrophilic Microfluidic Devices Produced Via The Primary- And In Situ Tertiary-Amine Catalyzed Michael Addition Of Multifunctional Thiols To Multifunctional Acrylates, Christopher O. Bounds

LSU Doctoral Dissertations

The objective of this research was to investigate amine-catalyzed thiol-acrylate chemistry for various novel applications that could fully utilize the untapped potential of this useful and robust chemistry. The use of this chemistry in each application solved a problem, improved on a disadvantage of current technologies, and decreased the level of complexity in association with required time, cost, and/or preparation conditions. The first novel application conceived, applied, and analyzed was in the field of microencapsulation. A novel approach for the preparation of microparticles via a dispersion polymerization using the primary amine-catalyzed addition of a trithiol to a triacrylate was realized …

Paley-Wiener Theorem For Line Bundles Over Compact Symmetric Spaces, Vivian Mankau Ho

LSU Doctoral Dissertations

We generalize a Paley-Wiener theorem to homogeneous line bundles $L_\chi$ on a compact symmetric space U/K with $\chi$ a nontrivial character of K. The Fourier coefficients of a $\chi$-bi-coinvariant function f on U are defined by integration of f against the elementary spherical functions of type $\chi$ on U, depending on a spectral parameter $\mu$, which in turn parametrizes the $\chi$-spherical representations $\pi$ of U. The Paley-Wiener theorem characterizes f with sufficiently small support in terms of holomorphic extendability and exponential growth of their $\chi$-spherical Fourier transforms. We generalize Opdam's estimate for the hypergeometric functions in a bigger domain with …

The Effect Of Inorganic Fillers On The Properties Of Wood Plastic Composites, Birm June Kim

LSU Doctoral Dissertations

The effect of inorganic fillers including precipitated calcium carbonate (PCC), glass fiber (GF), and nano-clay on properties of structured WPCs was investigated. In PCC-bamboo-polymer hybrid composites, tensile and flexural moduli were improved with increasing PCC content. After silane treatment of bamboo, RBF-filled hybrid composites showed better mechanical properties compared to those of GBP-filled hybrid composites. The hybrid composites showed 3-4 times higher modulus than those of PCC-filled composites at high PCC levels. Various property differences were observed between weak- and strong-core coextruded systems with shell composition changes. While the weak-core systems showed improved flexural strengths compared to their core-only control, …

Design, Synthesis, Characterization, And Application Of Peptides As Different Medical Treatment, Krystal Renee Fontenot

LSU Doctoral Dissertations

A peptide is defined, as a molecule that contains less than fifty amino acids; anything larger is a protein. Peptides are important molecules because they have diverse uses. Peptides were utilized in two ways: 1) Peptide bioconjugates containing a fluorescent porphyrin or phthalocyanine macrocycle were designed and investigated, with or without a PEG moiety for selective targeting of the epidermal growth factor receptor (EGFR). 2) Amyloid aggregating mitigating peptides (AAMPs) was synthesized and investigated containing polar amino acids, MiniPEGs, and/or ααAAs that have the ability to inhibit and disrupt Amyloid Beta (Aβ). The peptide bioconjugates containing a porphyrin or phthalocyanine …

Challenges In The Discovery And Characterization Of Magnetic Intermetallics, William A. Phelan

LSU Doctoral Dissertations

The crystal growth and characterization of four families of compounds, LnFeSb3 (Ln = Pr, Nd, Sm, Gd, and Tb) and CeCo(Sb, Sn)3, Ln2Fe4Sb5 (Ln = La – Nd and Sm), LnCu2(Al,Si)5 (Ln = La and Ce), and Ln(Cu,Al,Ga)13 (Ln = La – Pr and Eu), are presented in this dissertation. Special emphasis is placed on describing their structure-magnetic properties correlations. Discoveries and studies of these systems were motivated by their structurally related predecessors, which are comprised of complex structural subunits and exhibit unusual physical properties. The magnetic behaviors exhibited by a selection of these intermetallics include the large magnetoresistances and …

Novel Nonresonant And Resonant Mechanisms Leading To The Breakdown Of The Franck-Condon Approximation In Photoionization, David Adam Hardy

LSU Doctoral Dissertations

This thesis attempts to answer the question of how electrons interact with a molecular framework prior to and during emission through photoionization. These studies interrogate several behaviors of allowed and forbidden photoelectron transitions such as shape resonances, non-resonant intrachannel vibronic coupling as a result of Cooper minima, and chemically-induced nonresonant coupling, all of which provide new insights into correlations between the electronic and molecular degrees of freedom. Research presented in this thesis utilizes high-resolution photoelectron spectroscopy, and undulator-based synchrotron radiation at the Advanced Light Source, a synchrotron radiation source in Berkeley, California. Data are collected from near threshold to several …

A Seismic Attribute Study To Assess Well Productivity In The Ninilchik Field, Cook Inlet Basin, Alaska, Andrew Sampson

LSU Master's Theses

Coal bed methane which has formed in the Tertiary Kenai Group strata has been produced from the Ninilchik field of Cook Inlet, Alaska since 2001. Ninilchik field is located on the eastern margin of the central Cook Inlet along the Kenai Peninsula. Cook Inlet is a forearc basin and is characterized by northeast trending anticlines with upwards of 10,000 feet of Late Oligocene and younger, non-marine sediments. Highly variable well production within the Oligocene to Miocene Tyonek formation of the Kenai Group has been a source of uncertainty. A series of seismic attributes visualized in Schlumberger's Petrel® software were studied …

Biomass And Mass Balance Isotope Content Of Mussel Seep Populations, Philip Martin Riekenberg

LSU Master's Theses

Cold seep mussels, Bathymodiolus childressi, are common cold seep constituents that form large populations at upper continental slope (500-1000 m) cold seep sites in the Northern Gulf of Mexico. These mussels utilize methane present through symbiotic relationships with methanotrophic bacteria. This study uses a coupled isotope technique to determine the relative incorporation of respiratory carbon in the shell as a measure of the availability of methane between different seep sites. This method indicates a higher abundance of methane at the Brine Pool site than at the Bush Hill site which appears significantly more resource limited and that changes in methane …

Implications Of Geothermal History On Microbial Gas Generation And Coalbed Methane Production In The Ninilchik Field, Cook Inlet Basin, Alaska, Eric M. Hart

LSU Master's Theses

Coalbed methane (CBM) production operations atop the Ninilchik anticline of Cook Inlet, Alaska pose intriguing questions regarding the nature of biogenic gas generation in a thermally complex forearc basin setting. This thermal complexity stems, in part, from its up to 30,000 ft thick Tertiary section, comprised of braided stream alluvium and expansive, interbedded coal deposits. Rapid accumulation of cold, glacial strata is documented as being capable of regionally suppressing the elevated heat flux values expected within a forearc basin. In addition, beds with high organic content, such as the coal layers, act as natural insulators from basinal heat flux and …

Influences On Behavior Adaptations To Reduce Exposure To Environmental Hazards Among Residents Of Louisiana's Upper Industrial Corridor, Corrinthia Marie Hinton

LSU Master's Theses

Over the past century, the growth in petrochemical manufacturing within Louisiana’s Upper Industrial Corridor brought economic development, but also introduced toxic emissions and environmental exposure risks to residents of the area. For the citizens living in close proximity to multiple facilities there is the added risk of chemical exposure from environmentally hazardous accidents. This study seeks to gain insights into patterns of risk-reducing behaviors of residents in East Baton Rouge Parish so that better educational outreach programs can be developed. This research addresses the following questions: To what extent are residents of Baton Rouge taking steps to reduce environmental exposure …

Palynostratigraphy Of The Umir Formation, Middle Magdalena Valley Basin (Mmvb) Colombia, Carlos Enrique Santos

LSU Master's Theses

The Late Cretaceous Umir Formation in Middle Magdalena Valley Basin (MMVB) was recently acknowledged as a new target. However, there is little known about the regional distribution of the Umir Formation since it is affected by structural complexity and a major regional unconformity. To improve biosteering of the Umir Formation and reduce exploratory risks, a detailed biostratigraphic analysis of the Umir Formation in the MMVB is presented. Eighty samples from four cores drilled in the Central Eastern MMVB were analyzed for palynological content. These cores represent 976.6 meters of the Middle to Upper Umir Formation. The sediment yielded a good …

Modeling The Spatial And Temporal Dynamics Of Coastal Marsh Birds, Bradley A. Pickens

LSU Doctoral Dissertations

Wetland birds are likely to be influenced by habitat at multiple spatial scales, yet few studies have investigated bird responses at both broad and fine scales. Northern Gulf Coast marshes are dynamic ecosystems, and they provide an ideal place to examine habitat across spatial and temporal scales. My research focused on the secretive marsh bird guild (i.e. bitterns, rails, gallinules, grebes) with an emphasis on the king rail (Rallus elegans), a species of high conservation concern. My objectives were to investigate the wetland bird-environment relationship across scales, and to model annual changes in bird distribution. Study sites were in the …

Perpetual Requirements Engineering, Manuel Alfonso Peralta

LSU Doctoral Dissertations

This dissertation attempts to make a contribution within the fields of distributed systems, security, and formal verification. We provide a way to formally assess the impact of a given change in three different contexts. We have developed a logic based on Lewis’s Counterfactual Logic. First we show how our approach is applied to a standard sequential programming setting. Then, we show how a modified version of the logic can be used in the context of reactive systems and sensor networks. Last but not least we show how this logic can be used in the context of security systems. Traditionally, change …

Synthesis And Characterization Of Red And Near-Infrared Bodipy-Based Fluorophores For Various Biological Applications, Timsy Kaur Uppal

LSU Doctoral Dissertations

ABSTRACT 4,4-Difluoro-3a,4a-diaza-s-indacene, better known as BODIPY® dyes, have attracted considerable attention due to their intriguing physicochemical and spectral properties, including high absorption coefficient, fluorescence quantum yield and good photochemical stability. Despite the recent progress achieved in this field, the synthesis of BODIPY derivatives that absorb and emit in the red- and NIR-region of the electromagnetic spectrum and their application to biomolecular targets, represents a long-standing challenge in BODIPY chemistry. This research work is therefore focused on the synthesis and characterization of red and NIR-emissive BODIPY-based fluorophores for various bioanalytical and biomedical applications. Chapter 1 of this dissertation represents a concise …

Energy, Environment, And Sustainability: A Hierarchical Analysis Of South Louisiana, Matthew Korbel Moerschbaecher

LSU Doctoral Dissertations

This dissertation details research into the sustainability of industrial, human, and natural systems in south Louisiana. Chapter 1 is a general introduction. Chapter 2 calculates the energy return on financial investment (EROFI) of oil and gas production in the ultra-deepwater Gulf of Mexico (GoM) in 2009 and the Macondo Prospect (Mississippi Canyon Block 252). I calculated a preliminary Energy Return on Investment (EROI) using a range of energy intensity ratios. The EROFI for ultra-deepwater oil and gas at the wellhead was roughly 0.85 gallons, per dollar. These estimates of EROI for 2009 ultra-deepwater oil and natural gas at the wellhead …

Total Synthesis Of A Virotoxin And Analogs For Conformational Studies, Benson Jumba Edagwa

LSU Doctoral Dissertations

This dissertation describes the first total synthesis of alloviroidin in trace amounts, along with that of three analogs containing L-proline (Pro), trans-3-hydroxyproline (3-Hyp) or cis-4-hydroxyproline (4-hyp) residue substituting for 2,3-trans-3,4-trans-dihydroxyproline in the natural product. We report herein an efficient strategy that provides a dipeptide containing a (2S,4S)-4,5-dihydroxyleucine (dihyLeu) residue, including a diastereoselective dihydroxylation. Nα-Carbobenzyloxy-(2S)-4,5-dehydroleucine was coupled with valine ethyl ester to give a dipeptide that was subjected to a Sharpless asymmetric dihydroxylation to introduce the diol. The relative configuration at C4 was assigned as S by X-ray crystallography after derivatization as an α-amino-γ-lactone hydrochloride salt. The preparation of the 2-(methylsulfonyl)tryptophan …

The Effects Of Spatial Confinement And Oxygen Stoichiometry On Complex Metal Oxides, Zhaoliang Liao

LSU Doctoral Dissertations

Complex metal oxides, such as transition-metal oxides, appearing with exotic properties and optimal functionalities, present formidable challenges in condensed matter physics, while at the same time, immense opportunities in materials science and engineering. The signature of these materials is the multitude of competing ground states that can be tuned or manipulated by doping, structural modification, strain induction, or the application of external stimulus, such as pressure, electric or magnetic fields, etc. The interest in these materials stems from the richness of their novel properties, the complexity of underlying physics, and the promise of technological applications. Novel phenomena emerge by spatial …

Semantically-Aware Data Discovery And Placement In Collaborative Computing Environments, Xinqi Wang

LSU Doctoral Dissertations

As the size of scientific datasets and the demand for interdisciplinary collaboration grow in modern science, it becomes imperative that better ways of discovering and placing datasets generated across multiple disciplines be developed to facilitate interdisciplinary scientific research.

For discovering relevant data out of large-scale interdisciplinary datasets. The development and integration of cross-domain metadata is critical as metadata serves as the key guideline for organizing data. To develop and integrate cross-domain metadata management systems in interdisciplinary collaborative computing environment, three key issues need to be addressed: the development of a cross-domain metadata schema; the implementation of a metadata management system …

Biomass Energy Production In Louisiana: A Gis Study On The Supply Chain, Anil Raj Kizhakkepurakkal

LSU Doctoral Dissertations

One major drawback of biomass fuel is its bulky nature and the resulting high cost of transporting the fuel to the facility where the energy is being produced. Hence, supply chain of biomass residues plays a crucial role in determining the financial viability of bioenergy production. Transporting biomass for energy purposes more than 50 miles (80 km) is not considered economically feasible in most conditions. In the wood energy scenario, the maximum distance is more often restricted to distances of less than 200 km between production and consumption (via road). A study was done to determine logging residues and agricultural …

Subgradient Formulas For Optimal Control Problems With Constant Dynamics, Lingyan Huang

LSU Doctoral Dissertations

In this thesis our fi_x000C_rst concern is the study of the minimal time function corresponding to control problems with constant convex dynamics and closed target sets. Unlike previous work in this area, we do not make any nonempty interior or calmness assumptions and the minimal time functions is generally non-Lipschitzian. We show that the Proximal and Fréchet subgradients of the minimal time function are computed in terms of normal vectors to level sets. And we also computed the subgradients of the minimal time function in terms of the F-projection. Secondly, we consider the value function for Bolza Problem in optimal …

What Does The ¹⁴C Method For Estimating Photosynthetic Rates In The Ocean Really Measure?, Shaofeng Pei

LSU Doctoral Dissertations

The ¹⁴C method has been used extensively by both limnologists and oceanographers to measure photosynthetic rates in aquatic systems, and the large database of ¹⁴C measurements that now exists is the ground truth with which satellite algorithms for estimating marine photosynthetic rates on a basin and global scale have been calibrated. However, disconcerting uncertainties still remain with respect to whether and under what circumstances the ¹⁴C method provides an estimate of net or gross photosynthesis, or something in between. My study combined batch and continuous culture studies to clarify this ambiguous issue. The batch culture work with …

Variations In Pore Water Salinities Above And Below Allochthonous Salt Sheets In The Deepwater Gulf Of Mexico: Implications For Mechanisms Of Solute Transport, Miles Alexander Mccammon

LSU Master's Theses

Spatial variations in salinity of pore waters in marine sediments provide useful information on processes and rates of subseafloor fluid flow and solute transport, particularly if there are evaporites in the section. Pore water salinities were determined for 18 drill holes which penetrated allochthonous salt bodies in 12 widely-scattered protraction blocks on the Louisiana offshore continental shelf and slope. Salinities were calculated from Log ASCII Standard-Logging While Drilling (LAS-LWD) logs using the Revil et al. (1998) dual-conductivity technique. The sites represent a wide range of field settings. Water depths range from 30 to 1990 m, depths to the top of …