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Articles 8551 - 8580 of 12195

Full-Text Articles in Physical Sciences and Mathematics

Nutrient Addition And Drought Interact To Change The Structure And Decrease The Functional Diversity Of A Mediterranean Grassland, Carla Nogueira, Alice Nunes, Miguel N. Bugalho, Cristina Branquinho, Rebecca L. Mcculley, Maria Conceição Caldeira Oct 2018

Nutrient Addition And Drought Interact To Change The Structure And Decrease The Functional Diversity Of A Mediterranean Grassland, Carla Nogueira, Alice Nunes, Miguel N. Bugalho, Cristina Branquinho, Rebecca L. Mcculley, Maria Conceição Caldeira

Plant and Soil Sciences Faculty Publications

Anthropogenic activities are increasing nutrient availability and altering precipitation regimes. This may lead to critical changes in grasslands functioning. This is particularly important for grasslands in the Mediterranean Basin that have evolved in nutrient poor soils, and where more frequent and prolonged droughts are projected to occur. However, there is limited knowledge regarding the interacting effects of multiple nutrient inputs and rainfall variability on the plant functional structure and diversity of Mediterranean grasslands. We conducted a nutrient addition experiment in a Mediterranean grassland during four contrasting precipitation years. We established four treatments that varied in the number of added nutrients, …


Growth, Yield Performance And Quality Parameters Of Three Early Flowering Chia (Salvia Hispanica L.) Genotypes Cultivated In Southwestern Germany, Samantha J. Grimes, Timothy D. Phillips, Volker Hahn, Filippo Capezzone, Simone Graeff-Hönninger Oct 2018

Growth, Yield Performance And Quality Parameters Of Three Early Flowering Chia (Salvia Hispanica L.) Genotypes Cultivated In Southwestern Germany, Samantha J. Grimes, Timothy D. Phillips, Volker Hahn, Filippo Capezzone, Simone Graeff-Hönninger

Plant and Soil Sciences Faculty Publications

The combination of consumer’s ongoing demand for chia (Salvia hispanica L.) alongside the increased demand for regionally produced food products provided the impetus for this study. Its aim was to test if a regional cultivation of new chia genotypes, which were adapted to day lengths greater than 12 h, is feasible under Central European conditions. Therefore, three early flowering chia genotypes (Sahi Alba 914, W13.1, G8) were cultivated in a randomized block design at two experimental stations in Southwestern Germany (Ihinger Hof, Eckartsweier) over the course of two years (2015, 2016). Mean yields ranged from 100 to 1290 kg …


Can Maternity Benefits Have Long-Term Effects On Childbearing? Evidence From Soviet Russia, Olga Malkova Oct 2018

Can Maternity Benefits Have Long-Term Effects On Childbearing? Evidence From Soviet Russia, Olga Malkova

Economics Faculty Publications

This paper quantifies the effects of Russia’s 1981 expansion in maternity benefits on completed childbearing. The program provided one year of partially paid parental leave and a small cash transfer upon a child’s birth. I exploit the program’s two-stage implementation and find evidence that women had more children as a result of the program. Fertility rates rose immediately by 8.2% over twelve months. The increase in fertility rates not only persisted for the ten-year duration of the program, but it reflected large increases in higher-order births to older women who already had children before the program started.


Iac Gene Expression In The Indole-3-Acetic Acid-Degrading Soil Bacterium Enterobacter Soli Lf7, Isaac V. Greenhut, Beryl L. Slezak, Johan H. J. Leveau Oct 2018

Iac Gene Expression In The Indole-3-Acetic Acid-Degrading Soil Bacterium Enterobacter Soli Lf7, Isaac V. Greenhut, Beryl L. Slezak, Johan H. J. Leveau

Plant and Soil Sciences Faculty Publications

We show for soil bacterium Enterobacter soli LF7 that the possession of an indole-3-acetic acid catabolic (iac) gene cluster is causatively linked to the ability to utilize the plant hormone indole-3-acetic acid (IAA) as a carbon and energy source. Genome-wide transcriptional profiling by mRNA sequencing revealed that these iac genes, chromosomally arranged as iacHABICDEFG and coding for the transformation of IAA to catechol, were the most highly induced (>29-fold) among the relatively few (iac cluster were genes for a major facilitator superfamily protein (mfs) and enzymes of the β-ketoadipate pathway (pcaIJD-catBCA), which channels …


Biomass Production Of Herbaceous Energy Crops In The United States: Field Trial Results And Yield Potential Maps From The Multiyear Regional Feedstock Partnership, Do Kyoung Lee, Ezra Aberle, Erik K. Anderson, William Anderson, Brian S. Baldwin, David Baltensperger, Michael Barrett, Jürg Blumenthal, Stacy Bonos, Joe Bouton, David I. Bransby, Charlie Brummer, Pane S. Burks, Chengci Chen, Christopher Daly, Josh Egenolf, Rodney L. Farris, John H. Fike, Roch Gaussoin, John R. Gill, Kenneth Gravois, Michael D. Halbleib, Anna Hale, Wayne Hanna, Keith Harmoney, Emily A. Heaton, Ron W. Heiniger, Lindsey Hoffman, Chang O. Hong, Gopal Kakani, David Williams, Linda Williams Oct 2018

Biomass Production Of Herbaceous Energy Crops In The United States: Field Trial Results And Yield Potential Maps From The Multiyear Regional Feedstock Partnership, Do Kyoung Lee, Ezra Aberle, Erik K. Anderson, William Anderson, Brian S. Baldwin, David Baltensperger, Michael Barrett, Jürg Blumenthal, Stacy Bonos, Joe Bouton, David I. Bransby, Charlie Brummer, Pane S. Burks, Chengci Chen, Christopher Daly, Josh Egenolf, Rodney L. Farris, John H. Fike, Roch Gaussoin, John R. Gill, Kenneth Gravois, Michael D. Halbleib, Anna Hale, Wayne Hanna, Keith Harmoney, Emily A. Heaton, Ron W. Heiniger, Lindsey Hoffman, Chang O. Hong, Gopal Kakani, David Williams, Linda Williams

Plant and Soil Sciences Faculty Publications

Current knowledge of yield potential and best agronomic management practices for perennial bioenergy grasses is primarily derived from small‐scale and short‐term studies, yet these studies inform policy at the national scale. In an effort to learn more about how bioenergy grasses perform across multiple locations and years, the U.S. Department of Energy (US DOE)/Sun Grant Initiative Regional Feedstock Partnership was initiated in 2008. The objectives of the Feedstock Partnership were to (1) provide a wide range of information for feedstock selection (species choice) and management practice options for a variety of regions and (2) develop national maps of potential feedstock …


Sh-Mode Seismic-Reflection Imaging Of Earthfill Dams, Edward W. Woolery Oct 2018

Sh-Mode Seismic-Reflection Imaging Of Earthfill Dams, Edward W. Woolery

Earth and Environmental Sciences Faculty Publications

Assessing subsurface characteristics and imaging geologic features (e.g., faults, cavities, low-velocity layers, etc.) are typical problems in near-surface geophysics. These questions often have adverse geotechnical engineering implications, and can be especially acute when associated with high-hazard structures such as large earthen flood-control dams. Dam-related issues are becoming more frequent in the United States, because a large part of this major infrastructure was designed and constructed in the early- to mid-twentieth century; these dams are thus passing into the latter stages of their design life, where minute flaws that were overlooked or thought to be insignificant in design/construction are now …


Interrupted Time Series Design To Evaluate The Effect Of The Icd-9-Cm To Icd-10-Cm Coding Transition On Injury Hospitalization Trends, Svetla Slavova, Julia F. Costich, Huong Luu, Judith Fields, Barbara A. Gabella, Sergey Tarima, Terry L. Bunn Oct 2018

Interrupted Time Series Design To Evaluate The Effect Of The Icd-9-Cm To Icd-10-Cm Coding Transition On Injury Hospitalization Trends, Svetla Slavova, Julia F. Costich, Huong Luu, Judith Fields, Barbara A. Gabella, Sergey Tarima, Terry L. Bunn

Biostatistics Faculty Publications

Background: Implementation of the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) in the U.S. on October 1, 2015 was a significant policy change with the potential to affect established injury morbidity trends. This study used data from a single state to demonstrate 1) the use of a statistical method to estimate the effect of this coding transition on injury hospitalization trends, and 2) interpretation of significant changes in injury trends in the context of the structural and conceptual differences between ICD-9-CM and ICD-10-CM, the new ICD-10-CM-specific coding guidelines, and proposed ICD-10-CM-based framework for reporting of injuries by intent …


Lithologic Controls On Focused Erosion And Intraplate Earthquakes In The Eastern Tennessee Seismic Zone, Sean F. Gallen, J. Ryan Thigpen Sep 2018

Lithologic Controls On Focused Erosion And Intraplate Earthquakes In The Eastern Tennessee Seismic Zone, Sean F. Gallen, J. Ryan Thigpen

Earth and Environmental Sciences Faculty Publications

We present a new geomorphic model for the intraplate eastern Tennessee seismic zone (ETSZ). Previous studies document that the Upper Tennessee drainage basin is in a transient state of adjustment to ~150 m of base level fall that occurred in the Late Miocene. Using quantitative geomorphology, we demonstrate that base level fall resulted in the erosion of ~3,500 km3 of highly erodibility rock in an ~70 km wide by ~350‐km‐long corridor in the Paleozoic fold‐thrust belt above the ETSZ. Models of modern incision rates show a NE‐SW trending swath of elevated erosion ~30 km southeast of the center of …


Harmonic Decomposition Of Three-Particle Azimuthal Correlations At Energies Available At The Bnl Relativistic Heavy Ion Collider, L. Adamczyk, James K. Adkins, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, N. N. Ajitanand, I. Alekseev, D. M. Anderson, R. Aoyama, A. Aparin, D. Arkhipkin, E. C. Aschenauer, M. U. Ashraf, A. Attri, G. S. Averichev, X. Bai, V. Bairathi, A. Behera, R. Bellwied, A. Bhasin, A. K. Bhati, P. Bhattarai, J. Bielcik, J. Bielcikova, L. C. Bland, I. G. Bordyuzhin, J. Bouchet, J. D. Brandenburg, A. V. Brandin, D. Brown, Renee H. Fatemi, Suvarna Ramachandran Sep 2018

Harmonic Decomposition Of Three-Particle Azimuthal Correlations At Energies Available At The Bnl Relativistic Heavy Ion Collider, L. Adamczyk, James K. Adkins, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, N. N. Ajitanand, I. Alekseev, D. M. Anderson, R. Aoyama, A. Aparin, D. Arkhipkin, E. C. Aschenauer, M. U. Ashraf, A. Attri, G. S. Averichev, X. Bai, V. Bairathi, A. Behera, R. Bellwied, A. Bhasin, A. K. Bhati, P. Bhattarai, J. Bielcik, J. Bielcikova, L. C. Bland, I. G. Bordyuzhin, J. Bouchet, J. D. Brandenburg, A. V. Brandin, D. Brown, Renee H. Fatemi, Suvarna Ramachandran

Physics and Astronomy Faculty Publications

We present measurements of three-particle correlations for various harmonics in Au+Au collisions at energies ranging from √sNN = 7.7 to 200 GeV using the STAR detector. The quantity ⟨cos(1 + 2 − (m + n)ϕ3)⟩, with ϕ being the azimuthal angles of the particles is evaluated as a function of √sNN, collision centrality, transverse momentum, pT, pseudorapidity difference, Δη, and harmonics (m and n). These data provide detailed information on global event properties such as the three-dimensional structure of the initial …


Ultrafine Mineral Associations In Superhigh-Organic-Sulfur Kentucky Coals, James C. Hower, Debora Berti, Michael F. Hochella Jr. Sep 2018

Ultrafine Mineral Associations In Superhigh-Organic-Sulfur Kentucky Coals, James C. Hower, Debora Berti, Michael F. Hochella Jr.

Center for Applied Energy Research Faculty and Staff Publications

Two high-organic-sulfur Kentucky coals, the eastern Kentucky River Gem coal and the western Kentucky Davis coal, are examined by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), both including elemental analysis by energy-dispersive spectroscopy (EDS). From the SEM–EDS analysis, it is observed that the western Kentucky coal had areas with Pb and Cd in addition to the expected Fe and S and the eastern Kentucky coal had individual Fe–S-rich areas with La and Ni and with Si, Al, Cr, Ni, and Ti. TEM and selected area electron diffraction (SAED) analyses demonstrate that anglesite with a rim of Pb-bearing amorphous …


Quantifying Climate Sensitivity And Climate-Driven Change In North American Amphibian Communities, David A. W. Miller, Evan H Campbell Grant, Erin Muths, Staci M. Amburgey, Michael J. Adams, Maxwell B. Joseph, J. Hardin Waddle, Pieter T. J. Johnson, Maureen E. Ryan, Benedikt R. Schmidt, Daniel L. Calhoun, Courtney L. Davis, Robert N. Fisher, David M. Green, Blake R. Hossack, Tracy A. G. Rittenhouse, Susan C. Walls, Larissa L. Bailey, Sam S. Cruickshank, Gary M. Fellers, Thomas A. Gorman, Carola A. Haas, Ward Hughson, David S. Pilliod, Steve J. Price, Andrew M. Ray, Walt Sadinski, Daniel Saenz, William J. Barichivich, Adrianne Brand Sep 2018

Quantifying Climate Sensitivity And Climate-Driven Change In North American Amphibian Communities, David A. W. Miller, Evan H Campbell Grant, Erin Muths, Staci M. Amburgey, Michael J. Adams, Maxwell B. Joseph, J. Hardin Waddle, Pieter T. J. Johnson, Maureen E. Ryan, Benedikt R. Schmidt, Daniel L. Calhoun, Courtney L. Davis, Robert N. Fisher, David M. Green, Blake R. Hossack, Tracy A. G. Rittenhouse, Susan C. Walls, Larissa L. Bailey, Sam S. Cruickshank, Gary M. Fellers, Thomas A. Gorman, Carola A. Haas, Ward Hughson, David S. Pilliod, Steve J. Price, Andrew M. Ray, Walt Sadinski, Daniel Saenz, William J. Barichivich, Adrianne Brand

Forestry and Natural Resources Faculty Publications

Changing climate will impact species’ ranges only when environmental variability directly impacts the demography of local populations. However, measurement of demographic responses to climate change has largely been limited to single species and locations. Here we show that amphibian communities are responsive to climatic variability, using > 500,000 time-series observations for 81 species across 86 North American study areas. The effect of climate on local colonization and persistence probabilities varies among eco-regions and depends on local climate, species life-histories, and taxonomic classification. We found that local species richness is most sensitive to changes in water availability during breeding and changes in …


Low-PT E+ E- Pair Production In Au + Au Collisions At √SNn = 193 Gev And U + U Collisions At √SNn = 193 Gev At Star, J. Adam, L. Adamczyk, J. R. Adams, James K. Adkins, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, N. N. Ajitanand, I. Alekseev, D. M. Anderson, R. Aoyama, A. Aparin, D. Arkhipkin, E. C. Aschenauer, M. U. Ashraf, F. Atetalla, A. Attri, G. S. Averichev, X. Bai, V. Bairathi, K. Barish, A. J. Bassill, A. Behera, R. Bellwied, A. Bhasin, A. K. Bhati, J. Bielcik, J. Bielcikova, L. C. Bland, I. G. Bordyuzhin, Renee H. Fatemi, Suvarna Ramachandran Sep 2018

Low-PT E+ E- Pair Production In Au + Au Collisions At √SNn = 193 Gev And U + U Collisions At √SNn = 193 Gev At Star, J. Adam, L. Adamczyk, J. R. Adams, James K. Adkins, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, N. N. Ajitanand, I. Alekseev, D. M. Anderson, R. Aoyama, A. Aparin, D. Arkhipkin, E. C. Aschenauer, M. U. Ashraf, F. Atetalla, A. Attri, G. S. Averichev, X. Bai, V. Bairathi, K. Barish, A. J. Bassill, A. Behera, R. Bellwied, A. Bhasin, A. K. Bhati, J. Bielcik, J. Bielcikova, L. C. Bland, I. G. Bordyuzhin, Renee H. Fatemi, Suvarna Ramachandran

Physics and Astronomy Faculty Publications

We report first measurements of e+e pair production in the mass region 0.4 < Mee < 2.6  GeV/c2 at low transverse momentum (pT < 0.15  GeV/c) in noncentral Au+Au collisions at √sNN = 200  GeV and U+U collisions at √sNN = 193  GeV. Significant enhancement factors, expressed as ratios of data over known hadronic contributions, are observed in the 40%–80% centrality of these collisions. The excess yields peak distinctly at low pT with a width (√⟨p2T⟩) between 40 and 60  MeV/c. The absolute cross section of …


Structural Evolution And Petroleum Potential Of A Cambrian Intracratonic Rift System: Mississippi Valley Graben, Rough Creek Graben, And Rome Trough, John B. Hickman, David C. Harris Sep 2018

Structural Evolution And Petroleum Potential Of A Cambrian Intracratonic Rift System: Mississippi Valley Graben, Rough Creek Graben, And Rome Trough, John B. Hickman, David C. Harris

Report of Investigations--KGS

Drilling and geophysical data demonstrate that the Mississippi Valley Graben, Rough Creek Graben, and Rome Trough are fault-bounded structures filled with as much as 27,000 ft of Cambrian sediments. Data including stratigraphic tops from 1,764 wells, 106 seismic profiles, aeromagnetic and gravity surveys, and mapped surface geology at a scale of 1:24,000 were used to study seven stratigraphic packages across parts of Kentucky, Ohio, Indiana, Illinois, Missouri, and Tennessee. Detailed analysis of the thickness patterns of these stratigraphic packages was used to interpret the locations and timing of movement along major fault systems in the study area.

Active rifting of …


Continuum And Spectral Line Radiation From A Random Clumpy Medium, John E. Conway, Moshe Elitzur, Rodrigo Para Sep 2018

Continuum And Spectral Line Radiation From A Random Clumpy Medium, John E. Conway, Moshe Elitzur, Rodrigo Para

Physics and Astronomy Faculty Publications

We present a formalism for continuum and line emission from random clumpy media together with its application to problems of current interest, including CO spectral lines from ensembles of clouds and radio emission from H ii regions, supernovae, and star-forming regions. For line emission, we find that the effects of clump opacity on observed line ratios can be indistinguishable from variations of intrinsic line strengths, adding to the difficulties in determining abundances from line observations. Our formalism is applicable to arbitrary distributions of cloud properties, provided the cloud volume filling factor is small; numerical simulations show it to hold up …


Comprehensive Evaluation Of Treatment And Outcomes Of Low-Grade Diffuse Gliomas, Catherine R. Garcia, Stacey A. Slone, Thomas A. Pittman, William H. St. Clair, Donita D. Lightner, John L. Villano Sep 2018

Comprehensive Evaluation Of Treatment And Outcomes Of Low-Grade Diffuse Gliomas, Catherine R. Garcia, Stacey A. Slone, Thomas A. Pittman, William H. St. Clair, Donita D. Lightner, John L. Villano

Markey Cancer Center Faculty Publications

Background

Low-grade gliomas affect younger adults and carry a favorable prognosis. They include a variety of biological features affecting clinical behavior and treatment. Having no guidelines on treatment established, we aim to describe clinical and treatment patterns of low-grade gliomas across the largest cancer database in the United States.

Methods

We analyzed the National Cancer Database from 2004 to 2015, for adult patients with a diagnosis of World Health Organization grade II diffuse glioma.

Results

We analyzed 13,621 cases with median age of 41 years. Over 56% were male, 88.4% were white, 6.1% were black, and 7.6% Hispanic. The most …


Challenges And Techniques For Simulating Line Emission, Karen P. Olsen, Andrea Pallottini, Aida Wofford, Marios Chatzikos, Mitchell Revalski, Francisco Guzmán, Gergö Popping, Enrique Vázquez-Semadeni, Georgios E. Magdis, Mark L. A. Richardson, Michaela Hirschmann, William J. Gray Sep 2018

Challenges And Techniques For Simulating Line Emission, Karen P. Olsen, Andrea Pallottini, Aida Wofford, Marios Chatzikos, Mitchell Revalski, Francisco Guzmán, Gergö Popping, Enrique Vázquez-Semadeni, Georgios E. Magdis, Mark L. A. Richardson, Michaela Hirschmann, William J. Gray

Physics and Astronomy Faculty Publications

Modeling emission lines from the millimeter to the UV and producing synthetic spectra is crucial for a good understanding of observations, yet it is an art filled with hazards. This is the proceedings of “Walking the Line”, a 3-day conference held in 2018 that brought together scientists working on different aspects of emission line simulations, in order to share knowledge and discuss the methodology. Emission lines across the spectrum from the millimeter to the UV were discussed, with most of the focus on the interstellar medium, but also some topics on the circumgalactic medium. The most important quality of a …


Systemic Immunosuppression And Risk Of Age-Related Macular Degeneration, Harpal S. Sandhu, Joshua Lambert, Yan Xu, Henry J. Kaplan Sep 2018

Systemic Immunosuppression And Risk Of Age-Related Macular Degeneration, Harpal S. Sandhu, Joshua Lambert, Yan Xu, Henry J. Kaplan

Applied Statistics Laboratory Faculty Publications

A local immune response has been implicated in the pathogenesis of age-related macular degeneration (AMD), but it is unclear if systemic immunosuppressive/immunomodulatory therapy (IMT) protects against the onset and/or progression of AMD. We performed a retrospective cohort study using a Cox proportional hazards model of two cohorts. Cohort 1 included patients with stage V chronic kidney disease (CKD) status post kidney transplantation, on at least one IMT agent, and older than 50. Cohort 2 included patients with stage IV or V CKD who had not undergone kidney transplantation, were not on IMT, and were older than 50. The main outcomes …


Phosphorus And Potassium Fertilizer Application Strategies In Corn–Soybean Rotations, Timothy J. Boring, Kurt D. Thelen, James E. Board, Jason L. De Bruin, Chad D. Lee, Seth L. Naeve, William J. Ross, Wade A. Kent, Landon L. Ries Sep 2018

Phosphorus And Potassium Fertilizer Application Strategies In Corn–Soybean Rotations, Timothy J. Boring, Kurt D. Thelen, James E. Board, Jason L. De Bruin, Chad D. Lee, Seth L. Naeve, William J. Ross, Wade A. Kent, Landon L. Ries

Plant and Soil Sciences Faculty Publications

To determine if current university fertilizer rate and timing recommendations pose a limitation to high-yield corn (Zea mays subsp. mays) and soybean (Glycine max) production, this study compared annual Phosphorous (P) and Potassium (K) fertilizer applications to biennial fertilizer applications, applied at 1× and 2× recommended rates in corn–soybean rotations located in Minnesota (MN), Iowa (IA), Michigan (MI), Arkansas (AR), and Louisiana (LA). At locations with either soil test P or K in the sub-optimal range, corn grain yield was significantly increased with fertilizer application at five of sixteen site years, while soybean seed yield was significantly …


An Outlier Detection Algorithm Based On Cross-Correlation Analysis For Time Series Dataset, Hui Lu, Yaxian Liu, Zongming Fei, Chongchong Guan Sep 2018

An Outlier Detection Algorithm Based On Cross-Correlation Analysis For Time Series Dataset, Hui Lu, Yaxian Liu, Zongming Fei, Chongchong Guan

Computer Science Faculty Publications

Outlier detection is a very essential problem in a variety of application areas. Many detection methods are deficient for high-dimensional time series data sets containing both isolated and assembled outliers. In this paper, we propose an Outlier Detection method based on Cross-correlation Analysis (ODCA). ODCA consists of three key parts. They are data preprocessing, outlier analysis, and outlier rank. First, we investigate a linear interpolation method to convert assembled outliers into isolated ones. Second, a detection mechanism based on the cross-correlation analysis is proposed for translating the high-dimensional data sets into 1-D cross-correlation function, according to which the isolated outlier …


Association Analyses Of Repeated Measures On Triglyceride And High-Density Lipoprotein Levels: Insights From Gaw20, Saurabh Ghosh, David W. Fardo Sep 2018

Association Analyses Of Repeated Measures On Triglyceride And High-Density Lipoprotein Levels: Insights From Gaw20, Saurabh Ghosh, David W. Fardo

Biostatistics Faculty Publications

Background: The GAW20 group formed on the theme of methods for association analyses of repeated measures comprised 4sets of investigators. The provided “real” data set included genotypes obtained from a human whole-genome association study based on longitudinal measurements of triglycerides (TGs) and high-density lipoprotein in addition to methylation levels before and after administration of fenofibrate. The simulated data set contained 200 replications of methylation levels and posttreatment TGs, mimicking the real data set.

Results: The different investigators in the group focused on the statistical challenges unique to family-based association analyses of phenotypes measured longitudinally and applied a wide spectrum of …


Gaw20: Methods And Strategies For The New Frontiers Of Epigenetics And Pharmacogenomics, Nathan L. Tintle, David W. Fardo, Marzia De Andrade, Stella Aslibekyan, Julia N. Bailey, Justo Lorenzo Bermejo, Rita M. Cantor, Saurabh Ghosh, Philip Melton, Xuexua Wang, Jean W. Maccluer, Laura Almasy Sep 2018

Gaw20: Methods And Strategies For The New Frontiers Of Epigenetics And Pharmacogenomics, Nathan L. Tintle, David W. Fardo, Marzia De Andrade, Stella Aslibekyan, Julia N. Bailey, Justo Lorenzo Bermejo, Rita M. Cantor, Saurabh Ghosh, Philip Melton, Xuexua Wang, Jean W. Maccluer, Laura Almasy

Biostatistics Faculty Publications

GAW20 provided a platform for developing and evaluating statistical methods to analyze human lipid-related phenotypes, DNA methylation, and single-nucleotide markers in a study involving a pharmaceutical intervention. In this article, we present an overview of the data sets and the contributions analyzing these data. The data, donated by the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) investigators, included data from 188 families (N = 1105) which included genome-wide DNA methylation data before and after a 3-week treatment with fenofibrate, single-nucleotide polymorphisms, metabolic syndrome components before and after treatment, and a variety of covariates. The contributions from individual …


Longitudinal Data Methods For Evaluating Genome-By-Epigenome Interactions In Families, Justin C. Strickland, I-Chen Chen, Chanung Wang, David W. Fardo Sep 2018

Longitudinal Data Methods For Evaluating Genome-By-Epigenome Interactions In Families, Justin C. Strickland, I-Chen Chen, Chanung Wang, David W. Fardo

Psychology Faculty Publications

Background: Longitudinal measurement is commonly employed in health research and provides numerous benefits for understanding disease and trait progression over time. More broadly, it allows for proper treatment of correlated responses within clusters. We evaluated 3 methods for analyzing genome-by-epigenome interactions with longitudinal outcomes from family data.

Results: Linear mixed-effect models, generalized estimating equations, and quadratic inference functions were used to test a pharmacoepigenetic effect in 200 simulated posttreatment replicates. Adjustment for baseline outcome provided greater power and more accurate control of Type I error rates than computation of a pre-to-post change score.

Conclusions: Comparison of all modeling approaches indicated …


Latent Tuberculosis Infection Is Associated With Increased Unstimulated Levels Of Interferon-Gamma In Lima, Peru, Moises A. Huaman, David Henson, Paola L. Rondan, Eduardo Ticona, Gustavo Miranda, Richard J. Kryscio, Raquel Mugruza, Ernesto Aranda, Cesar Ticona, Susan Abarca, Paula Heredia, Andres Aguirre, Timothy R. Sterling, Beth A. Garvy, Carl J. Fichtenbaum Sep 2018

Latent Tuberculosis Infection Is Associated With Increased Unstimulated Levels Of Interferon-Gamma In Lima, Peru, Moises A. Huaman, David Henson, Paola L. Rondan, Eduardo Ticona, Gustavo Miranda, Richard J. Kryscio, Raquel Mugruza, Ernesto Aranda, Cesar Ticona, Susan Abarca, Paula Heredia, Andres Aguirre, Timothy R. Sterling, Beth A. Garvy, Carl J. Fichtenbaum

Internal Medicine Faculty Publications

Background

We previously reported increased unstimulated blood levels of interferon-gamma in persons with latent tuberculosis infection (LTBI) in the United States, suggesting enhanced immune activation in LTBI. To investigate this further in a TB-endemic setting, we assessed interferon-gamma levels in persons with and without LTBI in Peru.

Methods

We analyzed data from patients with and without a recent type 1 (spontaneous) acute myocardial infarction (AMI) who were enrolled from two public hospital networks in Lima, Peru, and underwent LTBI testing using the QuantiFERON® TB Gold In-tube (QFT) assay. Participants with a positive QFT test were defined as having LTBI, whereas …


Does Environment Filtering Or Seed Limitation Determine Post-Fire Forest Recovery Patterns In Boreal Larch Forests?, Wen H. Cai, Zhihua Liu, Yuan Z. Yang, Jian Yang Sep 2018

Does Environment Filtering Or Seed Limitation Determine Post-Fire Forest Recovery Patterns In Boreal Larch Forests?, Wen H. Cai, Zhihua Liu, Yuan Z. Yang, Jian Yang

Forestry and Natural Resources Faculty Publications

Wildfire is a primary natural disturbance in boreal forests, and post-fire vegetation recovery rate influences carbon, water, and energy exchange between the land and atmosphere in the region. Seed availability and environmental filtering are two important determinants in regulating post-fire vegetation recovery in boreal forests. Quantifying how these determinants change over time is helpful for understanding post-fire forest successional trajectory. Time series of remote sensing data offer considerable potential in monitoring the trajectory of post-fire vegetation recovery dynamics beyond current field surveys about structural attributes, which generally lack a temporal perspective across large burned areas. We used a time series …


On The Dynamics Of Near-Extremal Black Holes, Pranjal Nayak, Ashish Shukla, Ronak M. Soni, Sandip P. Trivedi, V. Vishal Sep 2018

On The Dynamics Of Near-Extremal Black Holes, Pranjal Nayak, Ashish Shukla, Ronak M. Soni, Sandip P. Trivedi, V. Vishal

Physics and Astronomy Faculty Publications

We analyse the dynamics of near-extremal Reissner-Nordström black holes in asymptotically four-dimensional Anti de Sitter space (AdS4). We work in the spherically symmetric approximation and study the thermodynamics and the response to a probe scalar field. We find that the behaviour of the system, at low energies and to leading order in our approximations, is well described by the Jackiw-Teitelboim (JT) model of gravity. In fact, this behaviour can be understood from symmetry considerations and arises due to the breaking of time reparametrisation invariance. The JT model has been analysed in considerable detail recently and related to the …


Beam Energy Dependence Of Rapidity-Even Dipolar Flow In Au + Au Collisions, J. Adam, L. Adamczyk, J. R. Adams, James K. Adkins, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, N. N. Ajitanand, I. Alekseev, D. M. Anderson, R. Aoyama, A. Aparin, D. Arkhipkin, E. C. Aschenauer, M. U. Ashraf, F. Atetalla, A. Attri, G. S. Averichev, X. Bai, V. Bairathi, K. Barish, A. J. Bassill, A. Behera, R. Bellwied, A. Bhasin, A. K. Bhati, J. Bielcik, J. Bielcikova, L. C. Bland, I. G. Bordyuzhin, Renee H. Fatemi, Suvarna Ramachandran Sep 2018

Beam Energy Dependence Of Rapidity-Even Dipolar Flow In Au + Au Collisions, J. Adam, L. Adamczyk, J. R. Adams, James K. Adkins, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, N. N. Ajitanand, I. Alekseev, D. M. Anderson, R. Aoyama, A. Aparin, D. Arkhipkin, E. C. Aschenauer, M. U. Ashraf, F. Atetalla, A. Attri, G. S. Averichev, X. Bai, V. Bairathi, K. Barish, A. J. Bassill, A. Behera, R. Bellwied, A. Bhasin, A. K. Bhati, J. Bielcik, J. Bielcikova, L. C. Bland, I. G. Bordyuzhin, Renee H. Fatemi, Suvarna Ramachandran

Physics and Astronomy Faculty Publications

New measurements of directed flow for charged hadrons, characterized by the Fourier coefficient v1, are presented for transverse momenta pT, and centrality intervals in Au+Au collisions recorded by the STAR experiment for the center-of-mass energy range √sNN=7.7–200 GeV. The measurements underscore the importance of momentum conservation, and the characteristic dependencies on √sNN, centrality and pT are consistent with the expectations of geometric fluctuations generated in the initial stages of the collision, acting in concert with a hydrodynamic-like expansion. The centrality and pT dependencies of v1even …


An Overview Of Dynamic Heterogeneous Oxidations In The Troposphere, Elizabeth A. Pillar-Little, Marcelo I. Guzman Sep 2018

An Overview Of Dynamic Heterogeneous Oxidations In The Troposphere, Elizabeth A. Pillar-Little, Marcelo I. Guzman

Chemistry Faculty Publications

Due to the adverse effect of atmospheric aerosols on public health and their ability to affect climate, extensive research has been undertaken in recent decades to understand their sources and sinks, as well as to study their physical and chemical properties. Atmospheric aerosols are important players in the Earth’s radiative budget, affecting incoming and outgoing solar radiation through absorption and scattering by direct and indirect means. While the cooling properties of pure inorganic aerosols are relatively well understood, the impact of organic aerosols on the radiative budget is unclear. Additionally, organic aerosols are transformed through chemical reactions during atmospheric transport. …


Effects Of The Affordable Care Act On Health Care Access And Self-Assessed Health After 3 Years, Charles J. Courtemanche, James Marton, Benjamin Ukert, Aaron Yelowitz, Daniela Zapata Sep 2018

Effects Of The Affordable Care Act On Health Care Access And Self-Assessed Health After 3 Years, Charles J. Courtemanche, James Marton, Benjamin Ukert, Aaron Yelowitz, Daniela Zapata

Economics Faculty Publications

Using data from the Behavioral Risk Factor Surveillance System, we examine the causal impact of the Affordable Care Act on health-related outcomes after 3 years. We estimate difference-in-difference-in-differences models that exploit variation in treatment intensity from 2 sources: (1) local area prereform uninsured rates from 2013 and (2) state participation in the Medicaid expansion. Including the third postreform year leads to 2 important insights. First, gains in health insurance coverage and access to care from the policy continued to increase in the third year. Second, an improvement in the probability of reporting excellent health emerged in the third year, with …


Gold-Catalyzed Conversion Of Lignin To Low Molecular Weight Aromatics, Yang Song, Justin K. Mobley, Ali Hussain Motagamwala, Mark Isaacs, James E. Dumesic, John Ralph, Adam F. Lee, Karen Wilson, Mark Crocker Sep 2018

Gold-Catalyzed Conversion Of Lignin To Low Molecular Weight Aromatics, Yang Song, Justin K. Mobley, Ali Hussain Motagamwala, Mark Isaacs, James E. Dumesic, John Ralph, Adam F. Lee, Karen Wilson, Mark Crocker

Chemistry Faculty Publications

A heterogeneous catalyst system, employing Au nanoparticles (NPs) and Li–Al (1 : 2) layered double hydroxide (LDH) as support, showed excellent activity in aerobic oxidation of the benzylic alcohol group in β-O-4 linked lignin model dimers to the corresponding carbonyl products using molecular oxygen under atmospheric pressure. The synergistic effect between Au NPs and the basic Li–Al LDH support induces further reaction of the oxidized model compounds, facilitating facile cleavage of the β-O-4 linkage. Extension to oxidation of γ-valerolactone (GVL) extracted lignin and kraft lignin using Au/Li–Al LDH under similar conditions produced a range of aromatic monomers in high yield. …


Seniority Structure Of 136Xe82, Erin E. Peters, P. Van Isacker, Anagha Chakraborty, Benjamin P. Crider, A. Kumar, S. H. Liu, Marcus T. Mcellistrem, C. V. Mehl, Francisco M. Prados-Estévez, T. J. Ross, J. L. Wood, Steven W. Yates Sep 2018

Seniority Structure Of 136Xe82, Erin E. Peters, P. Van Isacker, Anagha Chakraborty, Benjamin P. Crider, A. Kumar, S. H. Liu, Marcus T. Mcellistrem, C. V. Mehl, Francisco M. Prados-Estévez, T. J. Ross, J. L. Wood, Steven W. Yates

Chemistry Faculty Publications

The level structure of the N = 82 nucleus 136Xe was studied with the inelastic neutron scattering reaction followed by γ-ray detection. A number of the spins and parities were reassigned, and many level lifetimes were determined for the first time using the Doppler-shift attenuation method. New shell-model calculations were also performed using both the full Z = 50–82 model space, and a reduced model space including only the 1d5/2 and 0g7/2 orbitals. This new information characterizing 136Xe was used to identify the seniority structure of the low-lying levels and to assign (π …