Physical Sciences and Mathematics Commons^™

Mapping And Integrating Value Creation Factors With Life-Cycle Stages For Sustainable Manufacturing, P. Bilge, S. Emec, G. Seliger, Ibrahim S. Jawahir

Institute for Sustainable Manufacturing Faculty Publications

Instead of implementing each element individually, engineers must be aware of multiple interactions among all major value creation factors and their life-cycle stages. Interactions are analyzed by a set of factors and hierarchical levels within a production system based on empirical observations and described in analytical models. Such analyses and missing information about the current condition of the system and its parts remain limited to addressing specific aspects of interactions among factors and stages for multiple decision making. To build a case-based scope addressing the interactions among a set of factors and life-cycle stages, a comprehensive approach for mapping and …

Parallel Design Of A Product And Internet Of Things (Iot) Architecture To Minimize The Cost Of Utilizing Big Data (Bd) For Sustainable Value Creation, Ryan Bradley, Ibrahim S. Jawahir, Niko Murrell, Julie Whitney

Institute for Sustainable Manufacturing Faculty Publications

Information has become today's addictive currency; hence, companies are investing billions in the creation of Internet of Things (IoT) frameworks that gamble on finding trends that reveal sustainability and/or efficiency improvements. This approach to “Big Data” can lead to blind, astronomical costs. Therefore, this paper presents a counter approach aimed at minimizing the cost of utilizing “Big Data” for sustainable value creation. The proposed approach leverages domain/expert knowledge of the system in combination with a machine learning algorithm in order to limit the needed infrastructure and cost. A case study of the approach implemented in a consumer electronics company is …

Oxidation Of Substituted Catechols At The Air-Water Interface: Production Of Carboxylic Acids, Quinones, And Polyphenols, Elizabeth A. Pillar, Marcelo I. Guzman

Chemistry Faculty Publications

Anthropogenic activities contribute benzene, toluene, and anisole to the environment, which in the atmosphere are converted into the respective phenols, cresols, and methoxyphenols by fast gas-phase reaction with hydroxyl radicals (HO(•)). Further processing of the latter species by HO(•) decreases their vapor pressure as a second hydroxyl group is incorporated to accelerate their oxidative aging at interfaces and in aqueous particles. This work shows how catechol, pyrogallol, 3-methylcatechol, 4-methylcatechol, and 3-methoxycatechol (all proxies for oxygenated aromatics derived from benzene, toluene, and anisole) react at the air-water interface with increasing O3(g) during τc ≈ 1 μs contact time and contrasts their …

Identification Of Prognostic Genes And Gene Sets For Early-Stage Non-Small Cell Lung Cancer Using Bi-Level Selection Methods, Suyan Tian, Chi Wang, Howard H. Chang, Jianguo Sun

Biostatistics Faculty Publications

In contrast to feature selection and gene set analysis, bi-level selection is a process of selecting not only important gene sets but also important genes within those gene sets. Depending on the order of selections, a bi-level selection method can be classified into three categories – forward selection, which first selects relevant gene sets followed by the selection of relevant individual genes; backward selection which takes the reversed order; and simultaneous selection, which performs the two tasks simultaneously usually with the aids of a penalized regression model. To test the existence of subtype-specific prognostic genes for non-small cell lung cancer …

Catalyzed Synthesis Of Zinc Clays By Prebiotic Central Metabolites, Marcelo I. Guzman, Ruixin Zhou, Kaustuv Basu, Hyman Hartman, Christopher J. Matocha, S. Kelly Sears, Hajatollah Vali

Chemistry Faculty Publications

How primordial metabolic networks such as the reverse tricarboxylic acid (rTCA) cycle and clay mineral catalysts coevolved remains a mystery in the puzzle to understand the origin of life. While prebiotic reactions from the rTCA cycle were accomplished via photochemistry on semiconductor minerals, the synthesis of clays was demonstrated at low temperature and ambient pressure catalyzed by oxalate. Herein, the crystallization of clay minerals is catalyzed by succinate, an example of a photoproduced intermediate from central metabolism. The experiments connect the synthesis of sauconite, a model for clay minerals, to prebiotic photochemistry. We report the temperature, pH, and concentration dependence …

Outcomes After Diagnosis Of Mild Cognitive Impairment In A Large Autopsy Series, Erin L. Abner, Richard J. Kryscio, Frederick A. Schmitt, David W. Fardo, Daniela C. Moga, Eseosa T. Ighodaro, Gregory A. Jicha, Lei Yu, Hiroko H. Dodge, Chengjie Xiong, Randall L. Woltjer, Julie A. Schneider, Nigel J. Cairns, David A. Bennett, Peter T. Nelson

Epidemiology and Environmental Health Faculty Publications

OBJECTIVE: To determine clinical and neuropathological outcomes following a clinical diagnosis of mild cognitive impairment (MCI).

METHODS: Data were drawn from a large autopsy series (N = 1,337) of individuals followed longitudinally from normal or MCI status to death, derived from 4 Alzheimer Disease (AD) Centers in the United States.

RESULTS: Mean follow‐up was 7.9 years. Of the 874 individuals ever diagnosed with MCI, final clinical diagnoses were varied: 39.2% died with an MCI diagnosis, 46.8% with a dementia diagnosis, and 13.9% with a diagnosis of intact cognition. The latter group had pathological features resembling those with a final clinical …

A Compromised Liver Alters Polychlorinated Biphenyl-Mediated Toxicity, Banrida Wahlang, Jordan T. Perkins, Michael C. Petriello, Jessie B. Hoffman, Arnold J. Stromberg, Bernhard Hennig

Superfund Research Center Faculty Publications

Exposure to environmental toxicants namely polychlorinated biphenyls (PCBs) is correlated with multiple health disorders including liver and cardiovascular diseases. The liver is important for both xenobiotic and endobiotic metabolism. However, the responses of an injured liver to subsequent environmental insults has not been investigated. The current study aims to evaluate the role of a compromised liver in PCB-induced toxicity and define the implications on overall body homeostasis. Male C57Bl/6 mice were fed either an amino acid control diet (CD) or a methionine-choline deficient diet (MCD) during the 12-week study. Mice were subsequently exposed to either PCB126 (4.9 mg/kg) or the …

Level Of Patient-Physician Agreement In Assessment Of Change Following Conservative Rehabilitation For Shoulder Pain, Stephanie D. Moore-Reed, W. Ben Kibler, Heather M. Bush, Timothy L. Uhl

Biostatistics Faculty Publications

Background Assessment of health-related status has been shown to vary between patients and physicians, although the degree of patient–physician discordance in the assessment of the change in status is unknown.

Methods Ninety-nine patients with shoulder dysfunction underwent a standardized physician examination and completed several self-reported questionnaires. All patients were prescribed the same physical therapy intervention. Six weeks later, the patients returned to the physician, when self-report questionnaires were re-assessed and the Global Rating of Change (GROC) was completed by the patient. The physician completed the GROC retrospectively. To determine agreement between patient and physician, intra-class correlation (ICC) coefficient and Pearson’s …

Intraindividual Variability In Cortisol: Approaches, Illustrations, And Recommendations, Suzanne C. Segerstrom, Sandra E. Sephton, Philip M. Westgate

Psychology Faculty Publications

Most of the variance in diurnal cortisol is attributable to intraindividual variability (IIV), defined as relatively short-term, reversible changes. Multiple methods for measuring IIV have been proposed, and some have already been applied to cortisol IIV. In the present review, measurement methods are described and applied to simulated cortisol data with known underlying differences in IIV and to real cortisol data from first-year law students. More slope variance and more residual or net variance were well captured by their individual standard deviations. Explorations of reliability suggested that 10 slopes and 50 residuals result in reliable and stable estimates of the …

Reactivity Of Ketyl And Acetyl Radicals From Direct Solar Actinic Photolysis Of Aqueous Pyruvic Acid, Alexis J. Eugene, Marcelo I. Guzman

Chemistry Faculty Publications

The variable composition of secondary organic aerosols (SOA) contributes to the large uncertainty for predicting radiative forcing. A better understanding of the reaction mechanisms leading to aerosol formation such as for the photochemical reaction of aqueous pyruvic acid (PA) at λ ≥ 305 nm can contribute to constrain these uncertainties. Herein, the photochemistry of aqueous PA (5-300 mM) continuously sparged with air is re-examined in the laboratory under comparable irradiance at 38° N at noon on a summer day. Several analytical methods are employed to monitor the time series of the reaction, including (1) the derivatization of carbonyl (C═O) functional …

Collective Quadrupole Behavior In 106Pd, Francisco M. Prados-Estévez, Erin E. Peters, A. Chakraborty, M. G. Mynk, D. Bandyopadhyay, N. Boukharouba, S. N. Choudry, Benjamin P. Crider, P. E. Garrett, S. F. Hicks, A. Kumar, S. R. Lesher, C. J. Mckay, Marcus T. Mcellistrem, Sharmistha Mukhopadhyay, J. N. Orce, M. Scheck, J. R. Vanhoy, J. L. Wood, Steven W. Yates

Chemistry Faculty Publications

Excited states in ¹⁰⁶Pd were studied with the (n,n′γ) reaction, and comprehensive information for excitations with spin ≤6ℏ was obtained. The data include level lifetimes in the femtosecond regime, spins and parities, transition multipolarities, and multipole mixing ratios, which allow the determination of reduced transition probabilities. The E2 decay strength to the low-lying states is mapped up to ≈2.4 MeV in excitation energy. The structures associated with quadrupole collectivity are elucidated and organized into bands.

An Experimental Investigation Of Wing-Tip Vortex Decay In Turbulence, Hai G. Ghimire, Sean C. C. Bailey

Mechanical Engineering Faculty Publications

Particle image velocimetry measurements were conducted for a wing-tip vortex decaying in free-stream turbulence. The vortex exhibited stochastic collapse with free-stream turbulence present, with the breakdown initiating earlier for higher levels of turbulence. An increased rate of decay of the vortex tangential velocity was also observed, increasing with increasing free-stream turbulence. The decay of the vortex tangential velocity without the free-stream turbulence was well represented by viscous diffusion, resulting in an increase in the core radius and decrease in the peak tangential velocity. With the addition of free-stream turbulence, the rate of decay of the peak tangential velocity of the …

Ten Simple Rules For Responsible Big Data Research, Matthew Zook, Solon Barocas, Danah Boyd, Kate Crawford, Emily Keller, Seeta Peña Gangadharan, Alyssa Goodman, Rachelle Hollander, Barbara A. Koenig, Jacob Metcalf, Arvind Narayanan, Alondra Nelson, Frank Pasquale

Geography Faculty Publications

No abstract provided.

Photochemical Properties And Structure-Activity Relationships Of RuIi Complexes With Pyridylbenzazole Ligands As Promising Anticancer Agents, Dmytro Havrylyuk, David K. Heidary, Leona Nease, Sean Parkin, Edith C. Glazer

Chemistry Faculty Publications

Ruthenium complexes capable of light‐triggered cytotoxicity are appealing potential prodrugs for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT). Two groups of (polypyridyl)Ru^II complexes with 2‐(2‐pyridyl)benzazole ligands were synthesized and investigated for their photochemical properties and anticancer activity to compare strained and unstrained systems that are likely to have different biological mechanisms of action. The structure–activity relationship was focused on the benzazole‐core bioisosterism and replacement of coligands in Ru^II complexes. Strained compounds rapidly ejected the 2‐(2‐pyridyl)benzazole ligand after light irradiation, and possessed strong toxicity in the HL‐60 cell line both under dark and light conditions. In contrast, unstrained Ru …

Chemically Stable Artificial Sei For Li-Ion Battery Electrodes, Qinglin Zhang, Lei Han, Jie Pan, Zhi Chen, Yang-Tse Cheng

Chemical and Materials Engineering Faculty Publications

The importance of coating's chemical stability in lithium-ion batteries has been demonstrated by this study. It is well known that the mechanical properties determine the cycle life, and chemical stability or chemical degradation rate determines the calendar life. In this study, we used HfO₂ coatings prepared by atomic layer deposition as an example to show the chemical stability of the coatings for lithium ion battery electrodes.

Lifetimes In 124Te: Examining Critical-Point Symmetry In The Te Nuclei, S. F. Hicks, J. R. Vanhoy, P. G. Burkett, B. R. Champine, S. J. Etzkorn, P. E. Garrett, Steven W. Yates, Minfang Yeh

Physics and Astronomy Faculty Publications

The Doppler-shift attenuation method following inelastic neutron scattering was used to determine the lifetimes of nuclear levels to 3.3-MeV excitation in ¹²⁴Te. Level energies and spins, γ-ray energies and branching ratios, and multipole-mixing ratios were deduced from measured γ-ray angular distributions at incident neutron energies of 2.40 and 3.30 MeV, γ-ray excitation functions, and γγ coincidence measurements. The newly obtained reduced transition probabilities and level energies for ¹²⁴Te were compared to critical-point symmetry model predictions. The E(5) and β⁴ potential critical-point symmetries were also investigated in ¹²²Te and ¹²⁶Te.

A Local Leaky-Box Model For The Local Stellar Surface Density-Gas Surface Density-Gas Phase Metallicity Relation, Guangtun Ben Zhu, Jorge K. Barrera-Ballesteros, Timothy M. Heckman, Nadia L. Zakamska, Sebastian F. Sánchez, Renbin Yan, Jonathan Brinkman

Physics and Astronomy Faculty Publications

We revisit the relation between the stellar surface density, the gas surface density and the gas-phase metallicity of typical disc galaxies in the local Universe with the SDSS-IV/MaNGA survey, using the star formation rate surface density as an indicator for the gas surface density. We show that these three local parameters form a tight relationship, confirming previous works (e.g. by the PINGS and CALIFA surveys), but with a larger sample. We present a new local leaky-box model, assuming star-formation history and chemical evolution is localized except for outflowing materials. We derive closed-form solutions for the evolution of stellar surface density, …

First Measurement Of Unpolarized Semi-Inclusive Deep-Inelastic Scattering Cross Sections From A 3He Target, X. Yan, K. Allada, K. Aniol, J. R. M. Annand, T. Averett, F. Benmokhtar, W. Bertozzi, P. C. Bradshaw, P. Bosted, A. Camsonne, M. Canan, G. D. Cates, C. Chen, J. -P. Chen, W. Chen, K. Chirapatpimol, E. Chudakov, E. Cisbani, J. C. Cornejo, F. Cusanno, M. M. Dalton, W. Deconinck, C. W. De Jager, R. De Leo, X. Deng, A. Deur, H. Ding, P. A. M. Dolph, C. Dutta, D. Dutta, A. Kolarkar, Wolfgang Korsch

Physics and Astronomy Faculty Publications

The unpolarized semi-inclusive deep-inelastic scattering (SIDIS) differential cross sections in ³He(e,e′π^±)X have been measured for the first time in Jefferson Lab experiment E06-010 with a 5.9 GeV e⁻ beam on a ³He gas target. The experiment focuses on the valence quark region, covering a kinematic range 0.12 < x_bj < 0.45, 1 < Q² < 4 (GeV/c)², 0.45 < z_h < 0.65, and 0.05 < P_t < 0.55 GeV/c. The extracted SIDIS differential cross sections of π^± production are compared with existing phenomenological models while the ³He nucleus approximated as two protons and one …

Session 2c (Sediment And Nutrients), Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Real-Time Continuous Monitoring of Nutrients and Biological Parameters in Kentucky’s Rivers and Lakes, Mac Cherry, USGS Indiana-Kentucky Water Science Center
• Sediment Transport Modeling using Dynamic (Dis)connectivity to Assess Sediment Impacts on Water Quality, Tyler Mahoney and others, Dept. of Civil Engineering, University of Kentucky
• Sediment Nitrogen and Nitrate Dynamics of a Fluviokarst System in the Bluegrass Region: Isotopic and Numerical Modeling Investigation, Admin Husic and others, Dept. of Civil Engineering, University of Kentucky

Session 1c (Source Water Protection), Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• The Pleasant Grove Spring Non-Point Source Pollution Study: An Underused Data Set, James Currens, Kentucky Geological Survey
• Kentucky’s Source Water Protection Program, Robert Blair, Kentucky Division of Water
• Assistance Program for Source Water Protection: Success in Kentucky, Laura Norris and Allan Shingleton, Kentucky Division of Water

Poster Session 2, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

1. GIS as a Tool to Inform Field Studies and Reduce Human Health Exposure Risks, Evan Willett and others, Dept. of Civil Engineering, University of Kentucky
2. The Use of Environmental DNA to Detect Bacterial Molecular Markers in the Triplett Creek Watershed, Rowan County, Kentucky, Rachel Brown and others, Dept. Biology and Chemistry, Morehead State University
3. Detection of Percopsis ominsomaycus (TROUT-PERCH) using eDNA in Eastern Kentucky Streams, Ben Brammell and others, Dept. of Natural Sciences, Asbury University
4. Seasonal Fluctuations in Salamander eDNA in Central Kentucky Streams, Ronald Sams and others, Dept. Natural Sciences, Asbury University
5. Virtual 3D Septic …

Session 1b (Agriculture And Water), Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Feathered or Four-Legged: Working Together to Manage Manure in Kentucky, Amanda Gumbert and others, College of Agriculture, Food, and Environment, University of Kentucky
• There’s a Purple Cow in My MS4, Steve Higgins, College of Agriculture, Food and Environment, University of Kentucky
• Field Scale Characterization of Soil Hydraulic Conductivity and its Implication for Irrigation Management, Xi Zhang and Ole Wendroth, Dept. Plant and Soil Sciences, University of Kentucky

Session 2b (Biology), Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Microscale Electrokinetics for Phytoplankton Analysis, Stuart Williams, Mechanical Engineering Dept., University of Louisville and Susan Hendricks, Hancock Biological Station, Murray State University
• Selenium Reduction by a Co-Culture of Pantoea vagans strain EWB32213-2 and Shigella fergusonii strain TB42616, Yuxia Ji and Yi-tin Wang, Dept. of Civil Engineering, University of Kentucky
• Effects of Temperature and Macronutrient Ratios (N:P) on Microcystis aeruginosa Toxin Production and Growth, Brandon Yates and Brian Reeder, Dept. of Biology and Chemistry, Morehead State University

Session 1a (Soils And Geology), Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Potential Mechanism Contributing to the Development of Cover Collapse in Kentucky, James Currens, Kentucky Geological Survey
• Preliminary Assessment of the Geothermal Potential of the Alluvial Aquifer Beneath Louisville, Kentucky Created by Rising Groundwater Levels and Temperatures, Mike and K.G. Unthank, USGS Indiana- Kentucky Water Science Center
• Influence of Land Use on Soil Bulk Density, Infiltration, and NRCS Runoff Curve Number, Samuel Austen and others, Dept. of Biosystems and Agricultural Engineering, University of Kentucky

Session 2a (Climate Change/Data Platform), Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Assessing Climate Change and Impacts on Future Water Availability and Droughts in the Kentucky River Basin, Som Chattopadhyay and Dwayne Edwards, Dept. of Biosystems and Agricultural Engineering, University of Kentucky
• Variance Decomposition of Maxima Extreme Streamflow Forecasted with Global Climate Models, Nabil Al Aamery and Jimmy Fox, Dept. of Civil Engineering, University of Kentucky
• Aquavit: A HUBzero-Based Collaboration Portal for the AFI and SENSE Projects, Jack Smith and Justin Chapman, Marshall University

Poster Session 1, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

1. Sensing and Educating the Nexus to Sustain Ecosystems (SENSE): A Kentucky-West Virginia Partnership, Susan Hendricks and others, Hancock Biological Station, Murray State University
2. Using OpenNSPECT to Model Riparian Buffer Effectiveness for Mitigating Sediment Accumulation in Small Order Agricultural Streams, Lee Moser, College of Agriculture, Food and Environment, University of Kentucky
3. The Benefits of Staying Local – the Kentucky Section of the American Society of Agricultural and Biological Engineers, Carmen Agouridis and Michael Sama, Dept. of Biosystems and Agricultural Engineering, University of Kentucky
4. Overview of Groundwater Sampling Conducted in an Unconventional Oil and Gas Play Area of eastern …

Plenary Session, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Assessing Public Drinking Water Systems in Kentucky, Caroline Chan and Russell Neal, Kentucky Division of Water
• Bankfull Regional Curves and Hydraulic Geometry Curves for the Eastern Kentucky Coalfields, Ashlan Berry and Carmen Agrouridis, Dept. Biosystems and Agricultural Engineering, University of Kentucky
• Quasi-Three-Dimensional Hydrodynamic Model Development for Two-Phase Flow Applied to Geyser Phenomena in Urban Storm Sewers, Richard Shook and others, Dept. of Civil Engineering, University of Kentucky
• Curve Numbers for Urban Watersheds: A Problem and an Interim Solution, Robert Peterson and Lindell Ormsbee, Dept. of Civil Engineering, University of Kentucky

Proceedings Of 2017 Kentucky Water Resources Annual Symposium, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

This symposium was planned and conducted as a part of the state water resources research institute annual program that is supported by Grant/Cooperative Agreement Number G16AP00055 from the United States Geological Survey. The contents of this proceedings document and the views and conclusions presented at the symposium are solely the responsibility of the individual authors and presenters and do not necessarily represent the official views of the USGS or of the symposium organizers and sponsors. This publication is produced with the understanding that the United States Government is authorized to reproduce and distribute reprints for government purposes. Mention of trade …

Target And Beam-Target Spin Asymmetries In Exclusive Pion Electroproduction For Q2 > 1 Gev2. Ii. Ep → Eπ0P, P. E. Bosted, A. Kim, K. P. Adhikari, D. Adikaram, Z. Akbar, M. J. Amaryan, S. Anefalos Pereira, H. Avakian, R. A. Badui, J. Ball, I. Balossino, M. Battaglieri, I. Bedlinskiy, A. S. Biselli, S. Boiarinov, W. J. Briscoe, W. K. Brooks, S. Bültmann, V. D. Burkert, T. Cao, D. S. Carman, A. Celentano, S. Chandavar, G. Charles, T. Chetry, G. Ciullo, L. Clark, L. Colaneri, P. L. Cole, M. Contalbrigo, Wesley P. Gohn

Physics and Astronomy Faculty Publications

Beam-target double-spin asymmetries and target single-spin asymmetries were measured for the exclusive π⁰ electroproduction reaction γ^∗p → pπ⁰, expanding an analysis of the γ^∗p → nπ⁺ reaction from the same experiment. The results were obtained from scattering of 6-GeV longitudinally polarized electrons off longitudinally polarized protons using the CEBAF Large Acceptance Spectrometer at Jefferson Laboratory. The kinematic ranges covered are 1.1 < W < 3 GeV and 1 < Q² < 6 GeV². Results were obtained for about 5700 bins in W, Q², cos(θ^∗), and ϕ^∗. The beam-target asymmetries were found …

Utilizing Phluorin-Tagged Receptors To Monitor Subcellular Localization And Trafficking, Ashley M. Fox-Loe, Brandon J. Henderson, Christopher I. Richards

Chemistry Faculty Publications

Understanding membrane protein trafficking, assembly, and expression requires an approach that differentiates between those residing in intracellular organelles and those localized on the plasma membrane. Traditional fluorescence-based measurements lack the capability to distinguish membrane proteins residing in different organelles. Cutting edge methodologies transcend traditional methods by coupling pH-sensitive fluorophores with total internal reflection fluorescence microscopy (TIRFM). TIRF illumination excites the sample up to approximately 150 nm from the glass-sample interface, thus decreasing background, increasing the signal to noise ratio, and enhancing resolution. The excitation volume in TIRFM encompasses the plasma membrane and nearby organelles such as the peripheral ER. Superecliptic …