Physical Sciences and Mathematics Commons^™

Synthesis And Catalytic Applications Of Non-Metal Doped Mesoporous Titania, Syed Z. Islam, Suraj R. Nagpure, Doo Young Kim, Stephen E. Rankin

Chemical and Materials Engineering Faculty Publications

Mesoporous titania (mp-TiO₂) has drawn tremendous attention for a diverse set of applications due to its high surface area, interfacial structure, and tunable combination of pore size, pore orientation, wall thickness, and pore connectivity. Its pore structure facilitates rapid diffusion of reactants and charge carriers to the photocatalytically active interface of TiO₂. However, because the large band gap of TiO₂ limits its ability to utilize visible light, non-metal doping has been extensively studied to tune the energy levels of TiO₂. While first-principles calculations support the efficacy of this approach, it is challenging to …

Space Telescope And Optical Reverberation Mapping Project. V. Optical Spectroscopic Campaign And Emission-Line Analysis For Ngc 5548, L. Pei, M. M. Fausnaugh, A. J. Barth, B. M. Peterson, M. C. Bentz, G. De Rosa, K. D. Denney, M. R. Goad, C. S. Kochanek, K. T. Korista, G. A. Kriss, R. W. Pogge, V. N. Bennert, M. Brotherton, K. I. Clubb, E. Dalla Bontà, A. V. Filippenko, J. E. Greene, C. J. Grier, M. Vestergaard, W. Zheng, Scott M. Adams, Thomas G. Beatty, A. Bigley, Jacob E. Brown, Jonathan S. Brown, G. Canalizo, J. M. Comerford, Carl T. Coker, E. M. Corsini, Gary J. Ferland, S. A. Klimanov

Physics and Astronomy Faculty Publications

We present the results of an optical spectroscopic monitoring program targeting NGC 5548 as part of a larger multiwavelength reverberation mapping campaign. The campaign spanned 6 months and achieved an almost daily cadence with observations from five ground-based telescopes. The Hβ and He ii λ4686 broad emission-line light curves lag that of the 5100 Å optical continuum by 4.17^+0.36 _-0.36 days and 0.79^+0.35_-0.34 days respectively. The Hβ lag relative to the 1158 Å ultraviolet continuum light curve measured by the Hubble Space Telescope is ~50% longer than that measured against the optical continuum, and …

Polymer Micelle Formulation For The Proteasome Inhibitor Drug Carfilzomib: Anticancer Efficacy And Pharmacokinetic Studies In Mice, Ji Eun Park, Se-Eun Chun, Derek Alexander Reichel, Jee Sun Min, Su-Chan Lee, Songhee Han, Gongmi Ryoo, Yunseok Oh, Shin-Hyung Park, Heon-Min Ryu, Kyung Bo Kim, Ho-Young Lee, Soo Kyung Bae, Younsoo Bae, Wooin Lee

Pharmaceutical Sciences Faculty Publications

Carfilzomib (CFZ) is a peptide epoxyketone proteasome inhibitor approved for the treatment of multiple myeloma (MM). Despite the remarkable efficacy of CFZ against MM, the clinical trials in patients with solid cancers yielded rather disappointing results with minimal clinical benefits. Rapid degradation of CFZ in vivo and its poor penetration to tumor sites are considered to be major factors limiting its efficacy against solid cancers. We previously reported that polymer micelles (PMs) composed of biodegradable block copolymers poly(ethylene glycol) (PEG) and poly(caprolactone) (PCL) can improve the metabolic stability of CFZ in vitro. Here, we prepared the CFZ-loaded PM, PEG-PCL-deoxycholic …

Mccrearamycins A-D, Geldanamycin-Derived Cyclopentenone Macrolactams From An Eastern Kentucky Abandoned Coal Mine Microbe, Xiachang Wang, Yinan Zhang, Larissa V. Ponomareva, Qingchao Qiu, Ryan M. Woodcock, Sherif I. Elshahawi, Xiabin Chen, Ziyuan Zhou, Bruce E. Hatcher, James C. Hower, Chang-Guo Zhan, Sean Parkin, Madan K. Kharel, S. Randal Voss, Khaled A. Shaaban, Jon S. Thorson

Center for Pharmaceutical Research and Innovation Faculty Publications

Four cyclopentenone‐containing ansamycin polyketides (mccrearamycins A–D), and six new geldanamycins (Gdms B–G, including new linear and mycothiol conjugates), were characterized as metabolites of Streptomyces sp. AD‐23‐14 isolated from the Rock Creek underground coal mine acid drainage site. Biomimetic chemical conversion studies using both simple synthetic models and Gdm D confirmed that the mccrearamycin cyclopentenone derives from benzilic acid rearrangement of 19‐hydroxy Gdm, and thereby provides a new synthetic derivatization strategy and implicates a potential unique biocatalyst in mccrearamycin cyclopentenone formation. In addition to standard Hsp90α binding and cell line cytotoxicity assays, this study also highlights the first assessment of Hsp90α …

Glue Spin And Helicity In The Proton From Lattice Qcd, Yi-Bo Yang, Raza Sabbir Sufian, Andrei Alexandru, Terrence Draper, Michael J. Glatzmaier, Keh-Fei Liu, Yong Zhao

Physics and Astronomy Faculty Publications

We report the first lattice QCD calculation of the glue spin in the nucleon. The lattice calculation is carried out with valence overlap fermions on 2 + 1 flavor domain-wall fermion gauge configurations on four lattice spacings and four volumes including an ensemble with physical values for the quark masses. The glue spin SG in the Coulomb gauge in the modified minimal subtraction (MS¯) scheme is obtained with one-loop perturbative matching. We find the results fairly insensitive to lattice spacing and quark masses. We also find that the proton momentum dependence of S_G in the range 0 ≤ |p …

Lightweight Three-Factor Authentication And Key Agreement Protocol For Internet-Integrated Wireless Sensor Networks, Qi Jiang, Sherali Zeadally, Jianfeng Ma, Debiao He

Information Science Faculty Publications

Wireless sensor networks (WSNs) will be integrated into the future Internet as one of the components of the Internet of Things, and will become globally addressable by any entity connected to the Internet. Despite the great potential of this integration, it also brings new threats, such as the exposure of sensor nodes to attacks originating from the Internet. In this context, lightweight authentication and key agreement protocols must be in place to enable end-to-end secure communication. Recently, Amin et al. proposed a three-factor mutual authentication protocol for WSNs. However, we identified several flaws in their protocol. We found that their …

Efficient Revocable Id-Based Signature With Cloud Revocation Server, Xiaoying Jia, Debiao He, Sherali Zeadally, Li Li

Information Science Faculty Publications

Over the last few years, identity-based cryptosystem (IBC) has attracted widespread attention because it avoids the high overheads associated with public key certificate management. However, an unsolved but critical issue about IBC is how to revoke a misbehaving user. There are some revocable identity-based encryption schemes that have been proposed recently, but little work on the revocation problem of identity-based signature has been undertaken so far. One approach for revocation in identity-based settings is to update users' private keys periodically, which is usually done by the key generation center (KGC). But with this approach, the load on the KGC will …

Using The Vehicle Routing Problem To Reduce Field Completion Times With Multiple Machines, Hasan Seyyedhasani, Joseph S. Dvorak

Biosystems and Agricultural Engineering Faculty Publications

The Vehicle Routing Problem (VRP) is a powerful tool used to express many logistics problems, yet unlike other vehicle routing challenges, agricultural field work consists of machine paths that completely cover a field. In this work, the allocation and ordering of field paths among a number of available machines has been transformed into a VRP that enables optimization of completion time for the entire field. A basic heuristic algorithm (a modified form of the common Clarke-Wright algorithm) and a meta-heuristic algorithm, Tabu Search, were employed for optimization. Both techniques were evaluated through computer simulations in two fields: a hypothetical basic …

Convergence Rates In Periodic Homogenization Of Systems Of Elasticity, Zhongwei Shen, Jinping Zhuge

Mathematics Faculty Publications

This paper is concerned with homogenization of systems of linear elasticity with rapidly oscillating periodic coefficients. We establish sharp convergence rates in L² for the mixed boundary value problems with bounded measurable coefficients.

Air Exchange Rates And Alternatuve Vapor Entry Pathways To Inform Vapor Intrusion Exposure Risk Assessments, Rivka Reichman, Mohammadyousef Roghani, Evan J. Willett, Elham Shirazi, Kelly G. Pennell

Civil Engineering Faculty Publications

Vapor intrusion (VI) is a term used to describe indoor air (IA) contamination that occurs due to the migration of chemical vapors in the soil and groundwater. The overall vapor transport process depends on several factors such as contaminant source characteristics, subsurface conditions, building characteristics, and general site conditions. However, the classic VI conceptual model does not adequately account for the physics of airflow around and inside a building and does not account for chemical emissions from alternative “preferential” pathways (e.g. sewers and other utility connections) into IA spaces. This mini-review provides information about recent research related to building air …

Using A Respiratory Navigator Significantly Reduces Variability When Quantifying Left Ventricular Torsion With Cardiovascular Magnetic Resonance, Sean M. Hamlet, Christopher M. Haggerty, Jonathan D. Suever, Gregory J. Wehner, Kristin N. Andres, David K. Powell, Richard J. Charnigo, Brandon K. Fornwalt

Electrical and Computer Engineering Faculty Publications

Background: Left ventricular (LV) torsion is an important indicator of cardiac function that is limited by high inter-test variability (50% of the mean value). We hypothesized that this high inter-test variability is partly due to inconsistent breath-hold positions during serial image acquisitions, which could be significantly improved by using a respiratory navigator for cardiovascular magnetic resonance (CMR) based quantification of LV torsion.

Methods: We assessed respiratory-related variability in measured LV torsion with two distinct experimental protocols. First, 17 volunteers were recruited for CMR with cine displacement encoding with stimulated echoes (DENSE) in which a respiratory navigator was used to measure …

Recent Advances On Iron Oxide Magnetic Nanoparticles As Sorbents Of Organic Pollutants In Water And Wastewater Treatment, Angela M. Gutierrez, Thomas D. Dziubla, J. Zach Hilt

Superfund Research Center Faculty Publications

The constant growth in population worldwide over the past decades continues to put forward the need to provide access to safe, clean water to meet human needs. There is a need for cost-effective technologies for water and wastewater treatment that can meet the global demands and the rigorous water quality standards and at the same maximizing pollutant efficiency removal. Current remediation technologies have failed in keeping up with these factors without becoming cost-prohibitive. Most recently, nanotechnology has been sought as the best alternative to increase access to water supplies by remediating those already contaminated and offering ways to access unconventional …

Impact Of Nutrition On Pollutant Toxicity: An Update With New Insights Into Epigenetic Regulation, Jessie B. Hoffman, Michael C. Petriello, Bernhard Hennig

Superfund Research Center Faculty Publications

Exposure to environmental pollutants is a global health problem and is associated with the development of many chronic diseases, including cardiovascular disease, diabetes and metabolic syndrome. There is a growing body of evidence that nutrition can both positively and negatively modulate the toxic effects of pollutant exposure. Diets high in proinflammatory fats, such as linoleic acid, can exacerbate pollutant toxicity, whereas diets rich in bioactive and anti-inflammatory food components, including omega-3 fatty acids and polyphenols, can attenuate toxicant-associated inflammation. Previously, researchers have elucidated direct mechanisms of nutritional modulation, including alteration of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling, …

Environmental Challenges In Central And Eastern Europe, Bernhard Hennig

Superfund Research Center Faculty Publications

No abstract provided.

An Open-Sourced Statistical Application For Identifying Complex Toxicological Interactions Of Environmental Pollutants, Jordan T. Perkins, Michael C. Petriello, Li Xu, Arnold J. Stromberg, Bernhard Hennig

Superfund Research Center Faculty Publications

The rising number of chemicals that humans are exposed to on a daily basis, as well as advances in biomonitoring and detection technologies have highlighted the diversity of individual exposure profiles (complex body burdens). To address this, the toxicological sciences have begun to shift away from examining toxic agents or stressors individually to focusing on more complex models with multiple agents or stressors present. Literature on interactions between chemicals is fairly limited in comparison with dose-response studies on individual toxicants, which is largely due to experimental and statistical challenges. Experimental designs capable of identifying these complex interactions are often avoided …

Emerging Roles Of Xenobiotic Detoxification Enzymes In Metabolic Diseases, Michael C. Petriello, Jessie B. Hoffman, Andrew J. Morris, Bernhard Hennig

Superfund Research Center Faculty Publications

Mammalian systems have developed extensive molecular mechanisms to protect against the toxicity of many exogenous xenobiotic compounds. Interestingly, many detoxification enzymes, including cytochrome P450s and flavin-containing monooxygenases, and their associated transcriptional activators [e.g. the aryl hydrocarbon receptor (AhR)], have now been shown to have endogenous roles in normal physiology and the pathology of metabolic diseases. This mini-review will focus on two such instances: the role of flavin-containing monooxygenase 3 (FMO3) in the formation of the cardiometabolic disease biomarker trimethylamine-N-oxide (TMAO) and the role of AhR as a sensor of endogenous ligands such as those generated by the gut microbiota. Understanding …

The Fate Of Carbon In Sediments Of The Xingu And Tapajós Clearwater Rivers, Eastern Amazon, Dailson J. Bertassoli Jr., André O. Sawakuchi, Henrique O. Sawakuchi, Fabiano N. Pupim, Gelvam A. Hartmann, Michael M. Mcglue, Cristiano M. Chiessi, Matthias Zabel, Enno Schefuß, Tatiana S. Pereira, Rudney A. Santos, Samantha B. Faustino, Paulo E. Oliveira, Denise C. Bicudo

Earth and Environmental Sciences Faculty Publications

The Xingu and Tapajós rivers in the eastern Amazon are the largest clearwater systems of the Amazon basin. Both rivers have “fluvial rias” (i.e., lake-like channels) in their downstream reaches as they are naturally impounded by the Amazon mainstem. Fluvial rias are widespread in the Amazon landscape and most of the sedimentary load from the major clearwater and blackwater rivers is deposited in these channels. So far, little is known about the role of Amazon rias as a trap and reactor for organic sediments. In this study, we used organic and inorganic geochemistry, magnetic susceptibility, diatom, and pollen analyses in …

Photo Highlights Of The 36th Kentucky Alfalfa And Stored Forages Conference, Kentucky Alfalfa And Stored Forages Conference

Kentucky Alfalfa and Stored Forage Conference

No abstract provided.

Alfalfa Conference Speakers From The Beginning, Kentucky Alfalfa And Stored Forages Conference

Kentucky Alfalfa and Stored Forage Conference

No abstract provided.

Kentucky Alfalfa Awards History, Kentucky Alfalfa And Stored Forages Conference

Kentucky Alfalfa and Stored Forage Conference

The Kentucky Alfalfa Awards Program was initiated in 2000 at the 20th Anniversary of the Kentucky Alfalfa Conference. The Awards Program is funded annually from revenues generated each year for the Silent Auction during the Annual Conference.

Save The Date! [Announcement], S. Ray Smith, Krista Lea

Kentucky Alfalfa and Stored Forage Conference

This is an announcement of upcoming events.

Selecting Summer Annual Varieties Using Yield And Digestibility, Christopher D. Teutsch

Kentucky Alfalfa and Stored Forage Conference

Although cool-season grasses can provide ample and high quality forage for grazing livestock in the spring and fall, forage growth during the summer months is often restricted by high temperatures (Figure 1). In contrast warm-season annual grasses are most productive during the summer months and do not reach peak growth until temperatures approach 90 degrees Fahrenheit. Summer annual grasses such as forage sorghum (Sorghum bicolor (L.) Moench), sudangrass (Sorghum bicolor (L.) Moench), sorghum-sudangrass hybrids, and pearl millet (Pennisetum americanum (L.) Leeke) can provide high quality summer grazing for ruminant livestock in many regions of the United States.

The Economics Of Hay Quality, Madeline L. Dant, Kenneth H. Burdine, Brandon Sears

Kentucky Alfalfa and Stored Forage Conference

Hay quality is often discussed when one considers the viability of cash hay operations. A great deal is known about how production impacts quality and how quality impacts animal performance. This knowledge certainly has economic implications, but the economics of hay quality has primarily been evaluated from the animal performance perspective. Analyzing the economics of hay quality from the cash hay producer’s prospective becomes more difficult due to data limitations.

There are approximately 2.5 million acres of hay produced in Kentucky annually. The vast majority of this hay is grass type hay that is produced and fed on beef cattle …

What Is New In Seed Coatings, Bill Talley

Kentucky Alfalfa and Stored Forage Conference

Seed Coatings started many centuries ago when the Chinese wrapped their rice seed in a mud ball when planting their rice fields. The ball would keep the seed from floating to the top when they flooded their fields. Seed treatment of Alfalfa first began with preinoculation of the seed to make it more convenient to plant. The farmer did not have to go through the process of inoculating the seed himself, and this was a great improvement at the time. In 1975 Ramsey Seed in California acquired technology from a New Zealand company to begin coating seed with a buildup …

Western Hay Production Vs. Eastern Hay Production, Tom Keene

Kentucky Alfalfa and Stored Forage Conference

Early in the history of mankind, man was nomadic and moved from location to location in order to gather and find sustenance for themselves as well as their livestock. At some point in time, man decided that rather than keep moving, they would establish a community in one location, usually near running water (or fresh water of some kind), and would begin to sustain themselves with production agricultural practices.

Planting and harvesting soon took the place of packing up and moving every time the current resources had been depleted. Each year a new crop would be planted; livestock also became …

Why Is Intake Reduced When Cattle Are Fed Tall Fescue?, James L. Klotz

Kentucky Alfalfa and Stored Forage Conference

A major problem for the cattle producer that utilizes tall fescue forage is the unrealized or reduced gains in body weight in growing animals. This result has been reproduced across numerous studies evaluating cattle performance on tall fescue (Hoveland et al., 1983; Boling, 1985; Schmidt et al., 1986; Goetsch et al., 1987). Cattle have gained from 30 to 100% less consuming toxic endophyte-infected tall fescue compared to consumption of an endophyte-free tall fescue (Paterson et al., 1995). This effect of reduced gain is a consequence of a fungal endophyte present within the grass that produces toxins called ergot alkaloids. Fungal …

Understanding And Improving Fermentation In Alfalfa And Grass Baleage, Dennis Hancock

Kentucky Alfalfa and Stored Forage Conference

The ancient Egyptian and Carthaginians are believed to be the first conserve forage by ensiling it in the absence of oxygen. Though the technique has been refined in the 3500 years since, the basic fermentation process has not changed. Populations of naturally-occurring bacteria on the plant surface can consume some of the readily available carbohydrates and produce organic acids. These organic acids lower the pH of the forage material and prevent fungal deterioration of the product. Fermentation has been used for millennia as a natural method for preserving food. Similar bacterial fermentation occurs when one makes yogurt, sour cream, or …

Hay Making Weather In Kentucky: How To Get Good Information, Matthew Dixon, Tom Priddy

Kentucky Alfalfa and Stored Forage Conference

The UK Agricultural Weather Center, housed within the Department of Biosystems and Agricultural Engineering, was developed in 1978. As part of the Cooperative Extension Service, the goal of the Ag Weather Center is to minimize weather and climate related surprise for Kentucky residents and their agricultural needs, ultimately for profitable and sustainable production. In doing so, numerous tools and models have been developed throughout the years to further help farmers and producers in management and production related decisions.