Physical Sciences and Mathematics Commons^™

Novel Statistical Modeling Of Sleep Patterns In Drosophila Melanogaster, Luyang Wang

Doctoral Dissertations

”Sleep is one of the most important behaviors in animals, yet many aspects of sleep are not well understood. In humans, sleep has been shown to impact different aspects of health and cognitive performance. The fruit fly, Drosophila melanogaster, can be used as a model organism to investigate sleep patterns over an entire lifespan. The sleep-wake status can be recorded every minute over the life of individual flies, resulting in a wealth of data for identifying meaningful aspects of sleep. In this work, a framework based on statistical modeling methods is developed for sleep data collected on fruit flies …

Receiver Function Investigations Of Mantle Transition Zone And Crustal Structure In East Africa And Northeast Asia, Muchen Sun

Doctoral Dissertations

"In spite of numerous geophysical studies have been conducted in East Africa and Northeast Asia, the structure and evolution of the crust, upper mantle, and the mantle transition zone (MTZ) are still controversial. The MTZ discontinuities beneath the study area are imaged by stacking an unprecedented volume of receiver functions (RFs). The normal MTZ thickness beneath the Western Branch of the EARS and Tanzania Craton indicates the absence of present-day thermal upwelling from the lower mantle. In contrast, beneath the Eastern Branch, a significant MTZ thinning reveals the existence of thermal upwelling from either the upper MTZ or the lower …

Investigating Blast Fume Propagation, Concentration And Clearance In Underground Mines Using Computational Fluid Dynamics (Cfd), Raymond Ninnang Tiile

Doctoral Dissertations

"Blasting activities using standard industry explosives is an essential component of underground hard rock mining operations. Blasting operations result in the release of noxious gases, presenting both safety and productivity threats. Overestimation of post-blast re-entry time results in production losses, while underestimation leads to injuries and fatalities. Research shows that most underground mines simply standardize post-blast re-entry times based on experiences and observations. Few underground mines use theoretical methods for calculating post-blast re-entry time. These theoretical methods, however, are unable to account for the variations in the blasting conditions. Literature review shows that: (i) there is currently no means of …

Accurate Monitoring Of X, Y, And Z Magnetization For Analysis Of Hardware And Pulse Sequence Performance In Nmr Spectroscopy, Emmalou Theresa Schmittzehe

Doctoral Dissertations

"A new nuclear magnetic resonance (NMR) imaging protocol has been developed to independently record the x, y, and z components of the nuclear net magnetization at any point in a pulse sequence while eliminating the observation of the other components. This protocol provides an experimental method of tracking magnetization which then can be used in conjunction with theoretical models to scrutinize the predicted outcome of each step in an NMR pulse sequence and potentially find further improvements to their effectiveness and efficiency. The protocol utilizes a rapid rotating-frame imaging pulse-train technique to obtain RF-field (B₁) and resonance-offset (ΔB …

Modeling Of Hiv, Sir And Sis Epidemics On Time Scales And Oscillation Theory, Gülşah Yeni

Doctoral Dissertations

"We study higher dimensional systems of first order dynamic equations on time scales together with their applications. In particular, we focus on epidemic models such as HIV (Human Immunodeficiency Virus), SIS (Susceptible-Infected-Susceptible) and SIR (Susceptible-Infected-Recovered).

First, we generalize the early studied continuous three dimensional linear model of drug therapy for HIV-1 decline on time scales in order to derive new discrete models that predict the total concentration of plasma virus as a function of time. We compare these models to explore the impact of the theory of time scales. After fitting the models to the data collected at a clinical …

Development Of A Switchable Radioisotope Generator, Kyle Mitchell Paaren

Doctoral Dissertations

The Switchable Radioisotope Generator utilizes alpha-induced reactions to produce a combination of photons, neutrons, and protons with varying fluxes dependent on target materials and source geometry. The activity/strength of the secondary radiation is further controlled by manipulating the number of alpha particles that can interact with the target material(s). Analytical equations were solved to confirm secondary radiation production from target materials using average cross sections from TENDL data. TENDL and JENDL data was confirmed by analytically solving for the total alpha-induced cross sections. This information was used to produce the provisional and utility Patent No: US20190013109A1. TENDL data was then …

Seismic Attribute Assisted Depositional Facies Identification And Stratigraphic Correlation In The Central Gulf Coast Region Of Texas, Yani Lin

Doctoral Dissertations

"The sandstone deposits in the fluvial-dominated delta systems in the Lower Wilcox Group above the Cretaceous carbonate shelf edges of the Texas Gulf Coast Region are considered as high exploration potential reservoir bodies. However, the multi-phase regression and transgression during the late Paleocene to the early Eocene complicate the local depositional structure. The depositional facies is hard to be identified in details using the traditional seismic stratigraphic interpretation method. Seismic attributes are effective in detecting depositional facies, especially in mapping channels and investigating reservoir characteristics. In this study, we utilize seismic attributes to identify the principal depositional facies in the …

Reliability Analysis For Systems With Outsourced Components, Zhengwei Hu

Doctoral Dissertations

"The current business model for many industrial firms is to function as system integrators, depending on numerous outsourced components from outside component suppliers. This practice has resulted in tremendous cost savings; it makes system reliability analysis, however, more challenging due to the limited component information available to system designers. The component information is often proprietary to component suppliers. Motivated by the need of system reliability prediction with outsourced components, this work aims to explore feasible ways to accurately predict the system reliability during the system design stage. Four methods are proposed. The first method reconstructs component reliability functions using limited …

Privacy Preservation In Social Media Environments Using Big Data, Katrina Ward

Doctoral Dissertations

"With the pervasive use of mobile devices, social media, home assistants, and smart devices, the idea of individual privacy is fading. More than ever, the public is giving up personal information in order to take advantage of what is now considered every day conveniences and ignoring the consequences. Even seemingly harmless information is making headlines for its unauthorized use (18). Among this data is user trajectory data which can be described as a user's location information over a time period (6). This data is generated whenever users access their devices to record their location, query the location of a point …

Provenance And Depositional Environments Of The Upper Permian-Lowermost Triassic Fluvial And Lacustrine Sandstones, Wutonggou Low-Order Cycle, Bogda Mountains, Nw China, Dongyu Zheng

Doctoral Dissertations

"This work integrates petrographic and fieldwork studies and documents the spatial and temporal distributions of compositions and textures of the upper Permian-lowermost Triassic fluvial-lacustrine sandstones, Wutonggou low-order cycle (WTG LC), Bogda Mountains, NW China. In the first part, three petrofacies are identified on the basis of the relative abundances of quartz, feldspar, and lithics and conglomerate compositions and paleocurrent directions are documented. These data indicate that rocks of the eastern North Tianshan Suture (ENTS) and rift shoulders were the provenance lithology. Moreover, the upsection changes of petrofacies and conglomerate compositions suggest that the lithology of ENTS changed. During approximately Wuchiapingian, …

Electrodeposition Of Epitaxial Metal Thin Films On Silicon For Energy Conversion And Flexible Electronics, Qingzhi Chen

Doctoral Dissertations

"This research focuses on epitaxial electrodeposition of two coinage metals: Au and Ag thin films on the silicon surface and their applications in flexible electronics and energy conversion and storage. The first paper: Photoelectrochemistry of ultrathin, semi-transparent, and catalytic gold films electrodeposited epitaxially onto n-silicon (111) describes the epitaxial electrodeposition of Au thin films on n-type Si using a simple HAuCl4 bath and the photoelectrochemical properties of the Au-Si junction barrier. The effect of the Au layer on the interfacial energetics as well as the stability of the photoelectrode as a function of the Au coverage/thickness is determined in a …

Coherent Effects In Wave Propagation Through Complex Media, Milan Koirala

Doctoral Dissertations

"Diffusion is a powerful and versatile description of a typical wave propagation in a random scattering medium that disregards phase and, thus, a possibility of interference. Speckle, transmission fluctuations, wave localization, non-local correlations, and transmission eigenchannels are examples of persistent interference effects, which arise in the course of deterministic propagation. Such wave phenomena contain a wealth of information about the medium and the source of waves, enabling sensing and coherent control of the propagation. The nonlocal correlations and speckle statistics of the partially coherent light are used to uncover an object hidden by a diffusive cloak inside a strong scattering …

Nanomorphology Dependent Optical And Mechanical Properties Of Aerogels, Chandana Mandal

Doctoral Dissertations

"Aerogels are very low density, light weight open pore materials. A hypothesis that is under intense current investigation by the scientific community states that the mechanical properties of nanostructured polymers depend on their nanomorphology. Aerogels are nanostructured ultra-lightweight nanoporous materials with skeletal frameworks that can display a wide range of nanomorphologies. Thereby aerogels comprise a suitable platform for testing not only that hypothesis but also a wide range of other properties such as light scattering for applications, for example, in thermally insulating windows.

To study the mechanical properties of nanostructured matter as a function of nanomorphology, various shape-memory polyurethane aerogels …

Synthesis And Applications Of Ceramic (Silicon Carbide And Silicon Nitride), Metallic (Cobalt(0)) And Polymeric (Polyurethane) Aerogels, Parwani M. Rewatkar

Doctoral Dissertations

"A new method has been demonstrated for the synthesis of monolithic ceramic and purely metallic aerogels from xerogel powder compacts, and the use of polyurethane aerogels based on cyclodextrins as efficient desiccants.

I. Highly porous ( > 80%) monolithic SiC and Si₃N₄, aerogels were prepared from compressed compacts of polyurea-crosslinked silica xerogel powders. The process is time efficient as solvent-exchange through powders is fast, and energy efficient as it bypasses drying with supercritical fluids. The final ceramic objects were chemically pure, sturdy, with compressive moduli at 37 ±7 MPa and 59 ± 7 MPa, and thermal conductivities …

High Level Thermochemical And Spectroscopic Computations For Molecules Relevant To Combustion And The Atmosphere, Bradley K. Welch

Doctoral Dissertations

"Computational thermochemistry can be a complicated multistep process, but in recent years has become an equal partner with experiment. Many important molecules in combustion systems or in the atmosphere (such as short-lived radicals) are difficult to study experimentally. Predicting highly accurate thermochemistry is a key aspect in understanding these species. In this project, computational thermochemistry was developed into an automated streamlined procedure and then used to understand the methyl and ethyl peroxy families of radicals. This effort involved optimizing a standard workflow for computational thermochemistry. Computational thermochemistry generally requires numerous individual calculations whose cost and scalings vary widely. Conducting such …

Decoding The History Of The Early Solar System Using Comet Volatile Compositions, Nathaniel Xavier Roth

Doctoral Dissertations

"Understanding the evolution of the solar system, as well as its current volatile content, requires knowledge of the initial conditions present in the solar nebula. As some of the first objects to accrete in the solar nebula, cometary nuclei are among the most primitive remnants of solar system formation, and their present-day volatile composition likely reflects the composition and conditions where (and when) they formed. As such, the volatile compositions of cometary nuclei may serve as 'fossils' of solar system formation. High-resolution near-infrared spectroscopy offers a valuable tool for sampling the primary volatile (i.e., ices subliming directly from the nucleus) …

Applications Of Machine Learning In Nuclear Imaging And Radiation Detection, Shaikat Mahmood Galib

Doctoral Dissertations

"The main focus of this work is to use machine learning and data mining techniques to address some challenging problems that arise from nuclear data. Specifically, two problem areas are discussed: nuclear imaging and radiation detection. The techniques to approach these problems are primarily based on a variant of Artificial Neural Network (ANN) called Convolutional Neural Network (CNN), which is one of the most popular forms of 'deep learning' technique.

The first problem is about interpreting and analyzing 3D medical radiation images automatically. A method is developed to identify and quantify deformable image registration (DIR) errors from lung CT scans …

Development And Demonstration Of Sampling Techniques For A Chirped Pulse Fourier Transform Microwave Spectrometer, Frank Edward Marshall

Doctoral Dissertations

"With the introduction of the Chirped Pulse-Fourier Transform Microwave Spectrometer in the past decade, it has become possible to rapidly study the rotational spectra of molecules in the gas phase. It is possible to study molecules that are not normally in the gas phase through the use of various sourcing techniques. The development of both the heated nozzle and the laser ablation sourcing techniques allow for the study of liquids and solids, respectively. The design and performance of these sources will be presented in detail and discussed. Additionally, the development of a Multi-Antennae detection scheme, useful in improving overall sensitivity …

Dendrites Or Lambda-Dendroids As Generalized Inverse Limits, Faruq Abdullah Mena

Doctoral Dissertations

"This research centers on the study of generalized inverse limits. We show that all members of an infinite family of inverse limit spaces are homeomorphics to one particularly complicated inverse limit space known as "The Monster". Further, properties of factor spaces and graphs of bonding functions which are preserved in generalized inverse limit spaces with upper semi-continuous bonding functions with appropriate restrictions are investigated. Some of the properties are locally connectedness, hereditary decomposability, hereditary indecomposability, hereditary unicoherence, arc-likeness, and tree-likeness. The theorems are illustrated by several examples"--Abstract, page iv.

A Computational Study Of Sleep And The Hemispheres Of The Brain, Tera Ashley Glaze

Doctoral Dissertations

"Sleep and sleep cycles have been studied for over a century, and scientists have worked on modeling sleep for nearly as long as computers have existed. Despite this extensive study, sleep still holds many mysteries. Larger and more extensive sleep-wake models have been developed, and the circadian drive has been depicted in numerous fashions, as well as incorporated into scores of studies. With the ever-growing knowledge of sleep comes the need to find more ways to examine, quantify, and define it in the context of the most complex part of the human anatomy -- the brain. Presented here is the …

Paleoenvironment And Paleoclimate Of Ne Pangea In Early Permian-Linking Chemo- And Cyclo-Stratigraphy, Bogda Mountains, Nw China, Xin Zhan

Doctoral Dissertations

"The overall objective of this study is to understand physical and chemical responses of Earth Systems to environmental and climatic perturbations of diverse magnitudes and time scales in Bogda Mountains, NE Pangea. Field investigations, petrographic observations, and geochemical analyses have been used to interpret paleoenvironment and paleoclimate in cm-m-scale high-order cycles (HCs: 0.1-100 kyrs), low-order cycles (LCs: 1-10 Myr), and critical events of late Paleozoic ice age (LPIA: 320-260 Myr ago). Four organo-facies are one-to-one correlated with the four lithofacies in the meter-scale HCs, suggesting litho- and organo-facies are genetically linked and fundamentally controlled by environmental changes associated with lake …

Deep Neural Network Learning-Based Classifier Design For Big-Data Analytics, Krishnan Raghavan

Doctoral Dissertations

"In this digital age, big-data sets are commonly found in the field of healthcare, manufacturing and others where sustainable analysis is necessary to create useful information. Big-data sets are often characterized by high-dimensionality and massive sample size. High dimensionality refers to the presence of unwanted dimensions in the data where challenges such as noise, spurious correlation and incidental endogeneity are observed. Massive sample size, on the other hand, introduces the problem of heterogeneity because complex and unstructured data types must analyzed. To mitigate the impact of these challenges while considering the application of classification, a two step analysis approach is …

Fault Imaging Enhancement In Taranaki Basin, New Zealand And Rock Physics And Inversion Based Reservoir Characterization In The Central Gulf Coast Region Of Texas, Tianze Zhang

Doctoral Dissertations

"Fault imaging technique and reservoir characterization based on rock physics analysis and pre-stack inversion has been widely used hydrocarbon exploration. For the fault imaging technique, the ant tracking has been widely used in fault interpretation. However, the reliability of the results is highly dependent on appropriately choosing a signal processing method and volume attributes. In our study area, which lies in the southern Taranaki Basin, we applied Graphic Equalizer as the processing tool and the Chaos attribute before running the ant tracking algorithm. Results show that the procedure provides a better result and can map both the major and minor …

New Reproducing Kernel Hilbert Spaces On Plane Regions, Their Properties, And Applications To Partial Differential Equations, Jabar S. Hassan

Doctoral Dissertations

"We introduce new reproducing kernel Hilbert spaces W₂^(m,n) (D) on unbounded plane regions D. We study linear non-homogeneous hyperbolic partial differential equation problems on D with solutions in various reproducing kernel Hilbert spaces. We establish existence and uniqueness results for such solutions under appropriate hypotheses on the driver. Stability of solutions with respect to the driver is analyzed and local uniform approximation results are obtained which depend on the density of nodes. The local uniform approximation results required a careful determination of the reproducing kernel Hilbert spaces on which the elementary …

Mass Spectrometry Analysis Of Contaminants Of Emerging Concern: Nanoparticles, Algal Toxins, And Cyanotoxins In Natural Waters And Their Potential Health Impacts, Ariel R. Donovan

Doctoral Dissertations

“The analysis of contaminants of emerging concern is critical to protecting environmental health. In the presented dissertation, two groups of contaminants of emerging concern were assessed using mass spectrometry methods: nanoparticles and algal and cyanotoxins.

Analysis of metal oxide nanoparticles in environmental matrices has been a challenging issue, as most traditional methods require complicated sample preparation methods or that can alter or destroy the nanoparticles in the system. Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) methods were used to detect metal oxide nanoparticles in surface waters and their removal through drinking water treatment simulations while retaining all information regarding …

Development Of Functional Ionic Liquids For Separation And Recovery Of Rare Earth Elements, Mostafa Khodakarami

Doctoral Dissertations

“This research focused on the design and synthesis of task-specific ionic liquids for enhanced extraction and separation of rare earth elements (REEs). Two novel ammonium-based functional ionic liquids (FILs) with oxygen donating groups: trioctyl(2-ethoxy-2-oxoethyl)ammonium dihexyl diglycolamate, [OcGBOEt][DHDGA], and tricaprylmethylammonium dihexyl diglycolamate, [A336][DHDGA] were synthesized and tested for the recovery and separation of selected REEs from aqueous solutions. Functionalities with different denticities were incorporated into both anionic and cationic parts of ionic liquids, which are solely composed of incinerable atoms including C, H, O, and N. The structural, physical, and chemical properties of the synthesized FILs were studied using nuclear magnetic …

Design, Synthesis, Characterization And Anti-Cancer Effects Evaluation Of Interchain Cysteine Linked Antibody Drug Conjugates, Ke Li

Doctoral Dissertations

"Antibody drug conjugates (ADCs) are emerging therapeutic products specially designed for the treatment of cancers. Potent cytotoxic agents are linked to antibodies via linkers. Antibody drug conjugates, which take advantage of both antibodies and cytotoxic agents, showed high selectivity towards cancer cells. Cytotoxic agents are delivered to the cancer cells selectively and kill them from inside while leaving low or non-toxicity towards normal cells. Antibody drug conjugates are actually heterogeneous mixtures. The major heterogeneities mainly lie in the drug to antibody ratio (DAR) and drug linking positions, both of which potentially affect the therapeutic index of ADCs. In this research, …

The Benefit Of Precise Chemical Shift And Concentration Referencing In Nmr Applications, Ming Huang

Doctoral Dissertations

“In Nuclear Magnetic Resonance (NMR) spectroscopy, the chemical shift and intensity of NMR signals provide critical information about a sample's molecular structure, reaction conditions, and material properties. For the precise determination of structures and properties, it is critical to know sample or reaction conditions such as temperature, pH, concentration, or absolute amount of material. Chemical-shift and signal-intensity calibrations play a key role for extracting the maximum amount of information from NMR experiments. In this dissertation, internal and external reference standards are used to calibrate NMR spectra with respect to chemical shift and signal intensity. Sealed capillary tubes filled with specific …

Provenance, Redox Conditions, And Diagenesis Of Shales In Chang 7 Member Of Upper Triassic Yanchang Formation, Ordos Basin, China, Bin Sun

Doctoral Dissertations

“This study aims to decipher provenance, redox conditions, and burial history of shales in Chang 7 Member of Upper Triassic Yanchang Formation, Ordos Basin, China. The first paper discusses the origins of single-channeled, vertical, sinuous, and calcite-bitumen-filled cracks in the shales. Results show that in early diagenesis, unconsolidated mud was expanded open by escaping gases produced during organic matter maturation under hydrothermal influences. Calcite initially filled the cracks; bitumen and pyrite came in later and occupied the cracks in various ways. Compaction occurred next and folded the calcite- and bitumen-filled cracks into sinuous shapes. The second paper uses geochemical and …

Effective Magnetic And Electric Response Of Composite Materials, Mona Hassan Alsaleh

Doctoral Dissertations

Metamaterials (MMs) are nanocomposite materials consisting of metal-dielectric resonators much smaller in size than the wavelength of the incident light. Common examples of metamaterials are based on split ring resonators (SRRs), parallel wires or strips and fishnet structures. These types of materials are designed and fabricated in order to provide unique optical responses to the incident electromagnetic radiation that are not available in naturally existing materials. The MMs can exhibit unusual properties such as strong magnetism at terahertz (THz) and optical frequencies. Additionally, negative index materials (NIMs) can provide negative index of refraction which can be used in many applications …