Physical Sciences and Mathematics Commons^™

Sulfonium Salts, Aliphatic And Aromatic Diazonium Salts, Formation And Isolation, Geoffrey D. Picard

Honors Theses

An improved method for the preparation of diazonium salts was developed. Aliphatic diazonium salts were isolated for the first time. A method for their preparation was also worked out. The use of sulfonium salts as a route to deuteration of organic compounds was looked into.

Synthesis Of New Antimicrobial Agents, Michael John Burke

Honors Theses

Two new compounds have been synthesized in sufficient quantities to be tested for antimicrobial activity.

Dielectric Constants And Pair Interactions In Polar Molecules, Kurt Walter Hillig

Honors Theses

A qualitative description of dielectric processes in Pair interactions of polar molecules is presented, discussing such factors as molecular shape and polarizability. The mathematical treatment of these interactions is given, derived from classical electric field theory and statistical mechanics. The dielectric virial equation and the meaning of the dielectric virial coefficients is discussed. Due to the small magnitude of the coefficients, one must make measurements on the gas of the molar volume to one part in 10 4 and of the dielectric constant to one part in 106 to derive values of the second dielectric virial coefficient to within 10%. …

A Facile One Step Synthesis Of Some New 2-Hydroxy-4,6-Bis Aryl S-Triazines And Related Compounds, Howard Steven Grossberg

Honors Theses

In the past few years the symmetrical triazines have developed extreme importance in biochemical research as well as importance in industrial applications. In our research we have developed a facile, one-step synthesis of a number of 2-hydroxy-4, 6-bis aryl symmetrical triazines based upon the addition of the anion of urea and an aromatic nitrile, with the aryl group including a number of halogenated benzenes, pyridine, or benzene itself. The structure of these compounds has been proved by microanalysis and by both infra-red and mass spectroscopy. The further versatility of the synthesis has also been explored, and by replacing the urea …

Spectral Studies Of 9, 1 And 2-Methyl Anthroate And 2-Anthroic Acid, Thomas Glenn Matthews

Honors Theses

The substitution of a carboxyl group on the 9, 1 and 2-positions of anthracene produces several interesting changes in the characteristic spectral properties of the parent molecule. The absorption and fluorescence spectra, and fluorescence quantum yields of these carboxyl substituted anthracene compounds proved to be very solvent and position dependent. These spectra, quantum yields and related fluorescence lifetime data were used to determine the geometry of the ground and excited states for all three molecules. In the 9-position, molecular models and spectral evidence show that the plane of the carboxyl group is perpendicular to the plane of the ring in …

Principles Of Radioisotope Methodology, Gary Rothwell

Honors Theses

This honors project was designed for familiarization with modern instrumentation and experimentation methods for radioisotope detection and energy calculations. The two main instruments I studied were the Geiger-Mueller Counter and a single channel pulse height analyzer. This report will include a brief history of radiation and a description of the more important types. Next is a description of the two instruments mentioned and some simple experiments I conducted using them.

Hemorrhagic Component Of Northern Copperhead Venom, David Hill

Honors Theses

The major hemorrhagic component of northern copperhead (Agkistrodon contortrix mokasen) venom was partially purified by ion exchange and molecular sieve column chromatography. TAME and Phospholipase enzymatic activities were shown to be unrelated to hemorrhage. BAEE and procoagulant activities appear to be associated. Hide powder activity seems to correlate with hemorrhagic activity. Both show metal and disulfide dependences.

The northern copperhead, (Agkistrodon contortrix mokasen) is commonly found in forests from Massachusetts to Illinois, and in highlands as far south as Georgia and Alabama.

The venom of the northern copperhead has been reported to contain several en- zymatic activities as well as …

Solid Phase Peptide Synthesis, John Gibson

Honors Theses

Solid phase peptide synthesis is a relatively new biochemical process for polymerization of amino acids. It involves the selection of amino acids, blocking groups, and resins. This procedure was first investigated by R. B. Merrifield in an attempt to simplify previous methods of peptide synthesis. Since other methods involved amino acids, peptide esters, and diketopiperazines, peptide synthesis had been limited by amino acid selection and a host of technical problems. Solid phase synthesis alleviates many of these difficulties and limitations by supplying a faster and simpler stepwise addition of a wide variety of naturally occurring and synthetically prepared amino acids …

Spectral Studies Of Esters Of 9 And 1 Anthroic Acid, Robert Fisch

Honors Theses

A comparison was made between spectral properties of several atomatic esters of 9- anthroic acid (9- COOAR) and the methyl ester (9-COOMe). The spectral properties observed were absorption spectra, fluorescence quantum yields (Øf) and Stokes shifts. Although all of the ester absorption spectra showed anthracene-like structure, the aromatic ester spectra were clearly more diffuse than the 9-COOMe spectrum. Certain electron delocalization pathways are available to 9-COOAR but not to 9-COOMe, thereby allowing greater carboxyl group-ring interaction for 9-COOAR, resulting in increased spectral diffuseness relative to 9-COOMe. Data are presented which show that the electronic absorption spectra of these esters are …

The Reconversion Of Ethylene Thioketals To Ketones, Jeffrey Paul Ginther

Honors Theses

Many aldehydes, ketones and other carbonyl-containing compounds react with 1, 2-ethanedithol to give highly stable cyclic thioacetals or thioketals. The problem lies in recovering the substituted 1, 3-dithiolanes to the carbonyl compound without altering the other substituents of the molecule. We propose a new direct method of exchange with formaldehyde to reconvert the 1, 3-dithiolane to the carbonyl compound. This was accomplished with 2, 2-diethyl-l, 3-dithiolane. Also, a mechanism is proposed involving the formation of a sulfonium ion intermediate. In preparation for the exchange study seven 1, 3-dithiolanes were synthesized.

A Comparison Of The Spectral Properties Of Anthracene-9-Carboxylic Acid And Anthracene-9,10-Carboxylic Acid, Gail Wendy Goodman

Honors Theses

Previous studies have shown that substitution of a single carboxyl group on the anthracene ring produces fluorescent quantum yields (Øf) and Stokes shifts that are highly solvent dependent. The effects of solvents on the spectral properties of anthracene-9, 10-dicarboxylic acid (9, 10-(COOH) 2) which has symmetrically distributed carboxyl groups, was studied. Comparison is made with spectral data for 9-methyl anthroate (9-C00Me) and anthracene-9, 10-dicarboxylic acid (9, 10-(COOH) 2) which has symmetrically distributed carboxyl groups, was studied. Comparison is made with spectral data for 9-methyl anthroate (9-COOMe) and anthracene-9-carboxylix acid (9-COOH). The absorption and fluorescence spectra of the unprotonated forms of …

Theories On Planetary Motions, Jerry Thomason

Honors Theses

Anyone who has gazed into the starry sky with awe and amazement has often wondered what holds things together, where space ends and if there is no end, what wonders are beyond. The planets that are contained in this solar system and the growth of theories of the causes of the motions of these bodies are just some of the many wonders that a person can research.

In this work, I have intended to trace more or less a history of man's theories that govern the motions of the planets. I must admit that I will not cover by far …

The Schmidt Site: A Geologic Report, Julie Stein

Honors Theses

The Schmidt Site (20 SA 192) is located in Saginaw County, south of the Cass River and just east of the Grand Trunk Railroad in the NE 1/4, sec. 19, T 11 N, R 4 E, of the Bridgeport Township (figs. 1, 2, 3). The area is a remnant of a glacial lake bottom. There is very little local relief. Higher elevation exists to the north that is called the Port Huron Moraine and to the southeast, the Juniata, Owosso and Flint Moraines. All of these systems are associated with the last advance of ice, namely the Valders Advance (fig. …

Intuitive Concepts In Elementary Topology, Gary Rothwell

Honors Theses

My hour special study in intuitive topology originated in a curiosity of what exactly topology was and how it might be related to physics, my field of interest. The book I used was, Intuitive Concepts in Elementary Topology, by B.H. Arnold. This book is designed as a sophomore-junior level three hour course. Needless to say, I didn't quite cover the whole book in an hour a week. I mainly stuck to the intuitive concepts. Intuitive topology is dealing with more physical objects where the point set topology involves set theory; their unions, intersections and subsets.

Services Available To Admissions Office From Data Processing, Shirley Grant

Honors Theses

By using computer technology, such as punch cards, college admissions work flow can be better managed.

The Investigation Of The Use Of Fluorescein As A Spectral Probe Of Protein Environment, Michael Andrew Martin

Honors Theses

The study was iniated to investigate the properties of fluorescein as a reporter group or spectral probe of protein environment. Through spectral and flourescence studies it was determined that the flourescein binding sites were non-polar relative to bulk water. The spectral study also showed a lowering of pKA for the first one or two flourescein molecules to bind to the protein.

Formation Of An Isoquinoline In The Reaction Of A Diazoketone With Boron Trifluoride, Marc Maller

Honors Theses

It has been reported through work in the field of diazo chemistry that normal reactions of diazo ketones with certain acids can result in some unusual products. In the normal type reaction substituted methyl ketones are the resulting products which occur as a result of the elimination of nitrogen. However, the presence of a nucleophilic center at the ortho position of an aromatic diazo ketone can override the normal replacement and result in a cyclization product with the elimination of nitrogen. In these reactions it was found that addition of excess neoleophile still did not form open-chain products. Both four-and …

Liquid Crystals: Low Melting Nematic 4, 4'-Bis-(Alkylbenzal)-2-Chloro-1,4-Phenylenediamines, Herbert S. Cole Jr.

Honors Theses

Several homologues of the 4,4'-bis-(alkoxybenzal)-2-chloro-1,4-phenylene series were synthesized and their mesomorphic behavior characterized. Furthermore a new series of liquid crystalline compounds, 4,4 1 -bis­ (alkylbenzal)-chloro-l,4-phenylenediamines, have been synthesized and the mesomorphic behavior characterized up to the c carbon chain length. All homologues showed nematic behavior with broad mesophases and particularly low melting points.

A Study Of Indole-Ring Compounds In The Retina Of The Eye Of The Cow (With Special Emphasis Given To Melatonin And Serotonin), James Howard Kaye

Honors Theses

The literature justifies the hypothesis that there might be either serotonin or melatonin present in the retina of higher verta­brates. Serotonin has been demonstrated in nervous tissues from animals in all parts of the animal kingdom. As the retina is part of the central nervous system, it is a logical place to look for the presence of serotonin. Serotonin has also been found in the brain of ungulate fetuses. Serotonin has been measured in isolated bovine fetal brain some seventy-five to ninety days following gestation.

Iodination Of Aromatic Compounds, Paul T. Kabb

Honors Theses

Iodination of aromatic compounds was accomplished using the procedure given by Durand, with a few slight modifications introduced. Benzene was reacted with sulphuric acid, fuming sulphuric acid, and iodine to give hexaiodobenzene. Ethylbenzene was reacted with the mixture of sulphuric acids and iodine to give a mixture of less iodo-substituted products. Reduction using hydrogen atoms was accomplished. Hexaiodobenzene in the presence of dimethyl sulfoxide and sodium hydride was reduced to a mixture of less iodo-substituted products.

The Cationic Copolymerization Of B-Pinene And Styrene, William David Mciver

Honors Theses

The Catatonic polymerization process is least well known of the polymerization mechanisms. Copolymerization by cationic initiation is not well understood. Charles Snyder began investigating the copolymerization of B-pinene and styrene in the fall of 1971, and found some intersting things. He reported, however, that the project was incomplete. This project was based on the work that Snyde began. The products he made, in addition to several others, were completely analyzed in an effort to obtain information about the cationic polymerization process. DSC, GPC, and solvent studies, along with VPO, were the methods of analysis.

The Preparation Of 2,4,4',6,6'-Pentamethyldiborazinyl-1-2' By The Reaction Of B-Trichloroborazine With Grignard Reagent, David C. Sertl

Honors Theses

The goal of this research was to prepare crystals of 2,3,3',6,6'-pentamethyldibroazinyl1-1,2' in order to obtain vapor pressure data and a gas-phase, infrared spectrum.

Reactions Of Alkyl Halides In Dimethyl Sulfoxide Under Friedel-Crafts Conditions, Robert Wallace Dean Jr.

Honors Theses

When dimethyl sulfoxide, ethyl bromide, and 5 mole­-percent of ferric chloride are heated together, a yellow precipitate is formed. The product partially decomposes at 172 degrees, with evolution of gas. It is very soluble in water, but only slightly soluble in methanol. It contains 7.18% by weight of iron (III), suggesting a compound of high molecular weight or a mixture. It appears that a Friedel-Crafts alkylation of DMSO has taken place, perhaps giving an ethyldimethyloxosulfon­ium salt, however, the IR and NMR spectra do not substantiate this. The absence of alkoxydimethylsulfonium salts in the above reaction mixture has been demonstrated. An …

Effects Of Dipolar Aprotic Solvents And Ion Pairing On Elimination Reactions, David Andrew Benko

Honors Theses

An improved method for preparing t-butylacetylene was developed. Starting with t-butyl chloride, aluminum trichloride and vinyl bromide and followed by didehydroalogenation using potassium hydroxide in dimethyl sulfoxide, t-butylacetylene has been prepared in a better than 70% yield. In the process the effect of ion pairing on the orientation of elimination reactions was determined. From this a system for converting 2-haloalkanes directly into 2-alkenes was developed.

Synthesis Of N-Methyl-N-Benzyl-Beta-Chloro (Substituted Beta-Phenyl) Ethylamine Hychochloride, Mark Stuart Shulman

Honors Theses

β-haloalkyl amines are effective sympathetic blocking agents. An attempt was made to synthesize two β –haloakyl-amines, N-methyl, N-benzyl-β-chloro-β-(p-bromophenyl and 3,5 dichloro phenyl) ethylamine hydrochloride, in hopes that the compounds would have the pharmacological properties of a rapid onset, long duration, low toxicity, and few side effects. The basic criteria that β-haloalkylamine must have in order to display blocking properties are: tertiary amine, a β-haloakylamine group capable of forming an intermediate ethylenimonium ion, and an unsaturated ring substitute attached to the amine to allow ring stabilization. The compounds being synthesized display all these characteristics. The synthesis of N-methyl, N-benzyl- β-chloro β-(p-bromo-phenyl) …

Study Of Serotonin And Melatonin In The Bovine Retina, Paul Michael Parker

Honors Theses

The purpose of this research was to determine the presence of absence of the indoles serotonin and melatonin in the bovine retina. Their presence in the bovine pineal had been known for some time but no findings have been reported in the literature for bovine retinal tissue. Retinal tissue was extracted according to several procedures suggested by the literature. The extracts were tested against known samples of these indoles by thin layer chromatography and fluorescence spectra examined on the Hitachi-Perkin Elmer MPF-2 Fluorescence Spectrophotometer. The presence of melatonin in the bovine retina was qualitatively determined while not more than 0.01 …

Adrenergic Blocking Agents, Jeffrey Bruce Alifanz

Honors Theses

β-Haloalkylamines are a series of sympathetic blocking compounds. Phenoxybenzamine, the only commercially available β-haloalkylamine, goes under the trade name of dibenzyline and has an onset of sympathetic blocking effect of forty-five minutes and lasts for twenty-four to thirty-six hours. It requires a dose of 10-15 mg./kg. in previously anesthetized animals for full blocking effect and obviously its slowness of onset curtails its usefulness. N-Methyl-N-benzyl-β-chloro-β-phenyl-ethylaminehydrochloride also known as BMEA (for benzyl, methyl, phenethyl amine) differs by having an onset of sympathetic blockade of only five minutes and still has a duration in excess of seventeen hours. In addition, it is about …

Investigation Of The Relationship Of The Excited State Geometry Change And The Solvent Dependent Fluorescence Of 9-Methyl Anthroate, Ronald Michael Hoffman

Honors Theses

Due to a geometry difference, the polarity of the first excited singlet state of 9-methyl anthroate is shown to be greater than that of the ground state. This polarity difference results in solvent dependent fluorescence properties for this molecule. From the Stokes shift variations of 9-methyl anthroate fluorescence in polar aprotic solvents, the excited state dipole moment is 4.5 D larger than the ground state value. In protic solvents, the Stokes shifts are larger than in polar aprotic solvents indicating a large hydrogen bond contribution to excited state solvation in the former solvents. In non-polar and some polar aprotic solvents, …

Simulated Alpha Scattering, Gerald L. Fuller

Honors Theses

My approach to the experiment is to use a box of certain dimension as the Gold atom. This, I'm going to bombard with B.B's as alpha particles. Therefore this is a simulated alpha scattering experiment. The box is like unto the atom whereas shooting into it you cannot see what happens nor where it happens, but draw on your information taken while observe the effects outside the atom and the box likewise. A screen is used with the atom, and I have used a cardboard square placed in slats around my box to record the direction the particles enters and …

The Auditor And Statistical Sampling Techniques, Marilyn Metcalf

Honors Theses

"The auditor's overall objective is to determine whether the accounting process is free from material error." To complete his objective, the auditor must thoroughly analyze all aspects of the financial statements used in the accounting process in order to satisfy himself that they fairly represent the results of activity for the period under audit and of the financial position at the end of that period. If the volume of the transactions is great, time and economic factors may keep the auditor from making a 100 percent examination. Since a complete examination cannot be made, the auditor must choose a portion …