Physical Sciences and Mathematics Commons^™

The Synthesis And Properties Of New Potentially Chemotheraputic [Sic] Pteridine Derivatives, Walter Wesley Parish

Theses and Dissertations

A new general synthetic method for the preparation of 6-thiopteridines has been developed. The method involves the addition of thiols to intermediate pyrimidine nitrones formed in situ by the reaction of 4-amino-5-nitrosopyrimidines with pyridinium-activated acetonitriles, acetates, acetophenones, and other methylketones. Ca. forty new pteridines were prepared by this method. The preparation of six new 6-pteridinyl ketones, two new 6- pteridinyl ketone thiosemicarbazones, and two new 6-sulfonylpteridines and their 4-acetamido derivatives is also reported. 4-Acetamido-2- amino-7-phenylpteridine 5-oxide was prepared by the reaction of 2- amino-4,6-diacetamido-5-nitrosopyrimidine with either phenylsulfonyl-acetophenone or phenacylpyridinium bromide. Evidence relating to the structure of the acylated 4-amino-5- nitrosopyrimidines …

Donor Properties Of Dimethylsulfoniumcyclopentadienylide And Tetramethylenesulfoniumcyclopentadienylide In Metal Complexes ; Part Ii. The Attempted Preparation Of Boron Tricyanide, Gary Scott Barney

Theses and Dissertations

Part I.--Complexes of dimethylsulfoniumcyclopentadientylide and tetramethylenesulfoniumcyclopentadienylide with metal ions were studied in order to determine the coordination site on the ylids. Infrared spectra indicate that the ylids are coordinated through the cyclopentadienyl ring in all complexes except for the Hg(CN)2 complexes. Coordination-of the HgI2, CdI2, ZnCl2, and AgNO3 complexes is through the number one position on the ring as suggested by NMR data. Infrared and NMR data strongly indicate that the ylids in the Hg(CN)2 complexes are coordinated through sulfur. Part II.--The only method given in the chemical literature for the preparation of boron tricyanide could not be duplicated in …

Rates Of Hillslope Lowering In The Badlands Of North Dakota, John R. Tinker Jr.

Theses and Dissertations

Measurements in a small drainage basin in the Little Missouri Badlands of western North Dakota indicate an average rate of hillslope lowering by slopewash of 0.41 inch per year on the west-facing hillslopes underlain by the Sentinel Butte Formation, 0.14 inch per year on the southwest-facing hillslopes underlain by the Tongue River Formation, and 0.11 inch per year on the northeast-facing hillslopes underlain by the Tongue River Formation. Soil creep occurs mainly on the Tongue River Formation and is mostly restricted to the northeast-facing hillslopes where the average rate of soil creep parallel to the hillslope surface is 0.23 inch …

Quaternary Geology Of Rolette County, North Dakota, Dwight E. Deal

Theses and Dissertations

Rolette County contains approximately 942 square miles in north central North Dakota (Tps. 159-164 N., Rs. 69-73 W.) adjacent to the Canadian border. It includes the southeastern part of the Turtle Mountains and part of the glacial Lake Souris basin. Basic lithologies recognized in the surface sediments were bedded clay, silt, sand, and gravel; and three types of non-bedded diamicton. These were combined and, with bedding characteristics and organic content, formed 15 practical field mapping units. Geologically significant scarps and hill slopes were also mapped. The data collected is shown at a scale of 1 inch to 2 miles. The …

Groundwater Flow In Part Of The Little Missouri River Basin, North Dakota, Thomas M. Hamilton

Theses and Dissertations

The Little Missouri valley in western North Dakota is deeply incised into slightly permeable Mesozoic and Cenozoic sediments. An evaluation of the groundwater flow in part of this valley was 'based on the present groundwater flow-system models. Abrupt changes in the hydrochemical facies have been explained relative to a continuous flow system.

The Little Missouri valley ls the discharge area of a regional groundwater flow system; it affects the potential distribution of the flow system for a minimum of 1.000 feet below the valley floor. The discharge area is approximately the same width as the valley floor and has a …

Surficial Lineaments And Their Structural Implications In The Williston Basin, Kirth Kirth Erickson

Theses and Dissertations

Lineaments of apparent geostructural origin are observable on air photos of the Williston basin. The pattern formed by these lineaments has the appearance of a broad system of interconnecting wrench faults such as occur on the adjacent Canadian shield. On this basis it is hypothesized that a broad system of left-lateral wrench faults may underlie the Williston basin region and possibly the entire continental foreland structural province.

Structures in the Williston basin are readily adaptable to this interpretation. The Nessen anticline appears to consist of a north-south realignment of a N. 40° E.- trending Precambrian high which was segmented by …

Authigenic Analcite In The Golden Valley Formation Southwestern North Dakota, Marvin J. Furman

Theses and Dissertations

Authigenic analcite constitutes up to about 60 percent of a massive, arksosic sandstone exposed on major buttes in the North Dakota Badlands. The analcite constitutes up to about 80 percent of a thin analcimolite bed at the top of the arkose unit. The analcite occurs as spherulites in the interstices of the arkose and as a cement in the analcimolite. Three types of spherulites are recognized: (1) spherulites with an internal radial structure; (2) spherulites with a massive center and a peripheral radial structure; and (3) spherulites lacking an internal radial structure or having a poorly-defined internal structure. The spherulites …

Paleoenvironmental Reconstruction Of Late Quaternary Lacustrine Sediments (Seibold Site) In Southeastern North Dakota, William B. Bickley Jr.

Theses and Dissertations

The Seibold Site on the Missouri Coteau in northwest Stutsman County, North Dakota, contains a late Quaternary lacustrine deposit with a spectaculary preserved and diverse biota; more than 150 species occur, of which the mollusks and fish are figured and discussed in detail in this study. The stratigraphic sequence, in ascending order, is a follows: 1) pebbly silt; 2) clayey silt; 3) organic mud; 4) calcareous mud; 5) sandy silt and clay; 6) silty sand; and 7) sandy silt and clay.

The stratigraphic sequence and biota suggest a 5-phase history for the area during the last 11,000 years. During phase …

Molluscan Paleontology Of The Pierre Shale (Upper Cretaceous), Bowman County, North Dakota, Kenneth F. Brinster

Theses and Dissertations

The Pierre Shale of Campanian and Early Maestrichtian age in Bowman County, southwestern North Dakota, has an abundant molluscan fauna and 51 species are described herein. The 51 species consist of 1 species of scaphopod, 13 species in 11 genera of gastropods, 24 species' in 17 genera of bivalves, and 13 species in 6 genera of cephalopods.

The stratigraphy of the Pierre Shale in Bowman County was not compiled into a composite section because of the homogeneity of the shale, the lack of distinctive lithologic units, and the slumped condition of the shale. However, the biostratigraphic position of the Bowman …

Petrography Of Xenolith Zones In The Black Face-Ames Plutons, Western San Juan Mountains, Colorado, Richard B. Moore

Theses and Dissertations

The middle to late Tertiary Black Face-Ames plutons are irregularly-shaped, intrusive bodies located in the San Miguel Mountains of southwestern Colorado. The Ames pluton is generally a composite sill; the Black Face pluton is an asymmetric laccol1th. The two plutons are probably joined at depth, and together they form a crudely annular outcrop pattern, open toward the west. The principal rock type within the plutons is granodiorite porphyry, although part of the Ames pluton consists of porphyritic rhyodacite.

Two major zones of xenoliths of Precambrian rock occur within the Black Face-Ames plutons; scattered xenoliths are found at widely separated locations. …

A Thermodynamic Approach To The Study Of Phase Equilibria In The Sodium-Potassium Alloy System I. The Phase Diagram For Nak At Atmospheric Pressure ; Ii. High Pressure Phase Studies, Donald Ray Anderson

Theses and Dissertations

Ultra-pure reagents, platinum resistance thermometry and modern inert atmosphere glove box facilities have made possible a detailed examination of the NaK system at atmospheric pressure. A thermoanalytical study of solid-liquid phase equilibria in the NaK alloy system was conducted in the tetrahedral press to 55 kbars to investigate possible intermediate compound formation and shifting of the invariant points at various pressures. An expected shift in the eutectic composition to lower potassium content with an increase in the halt temperature on increasing pressure was confirmed. A merging of the meritectic and eutectic points at 343 ±2°K and 37 ±3 kbars occurred …

Solid-Liquid Phase Equilibria Of The Sodium-Rubidium And Sodium-Potassium-Rubidium Alloy Systems, Chen-Chao Hsu

Theses and Dissertations

Thermal methods were used, to determine with high precision, the solid-liquid phase equilibria diagrams for the sodium-rubidium and sodium-potassium-rubidium systems. In the sodium-rubidium system, the results differ greatly from those of earlier works, especially near the eutectic composition where differences in freezing points as large as 25°K occur. A detailed search was made for possible intermetallic compounds (especially Na2Rb). Neither slow temperature cycling in the temperature range where compound formation could occur nor extended periods of annealing just above the eutectic temperature produced any evidence for compound formation in the sodium-rubidium system. A 2:1 (sodium to rubidium) sample was subjected …

The Catalytic Hydrogenation Of Benzodiazines.|Ni.|Pphthlazine.|Nii.|Pquinazoline, Danny Lee Elder

Theses and Dissertations

Quinazoline and phthalazine were hydrogenated at low pressure and temperature (60 psi, room temperature) and high pressure and temperature (2000 psi, 100°C, 150°C} in neutral and acidic solvents over 5% Pd/C, 5% Ru/C, 5% Rh/Al2O3 , 5% Rh/C, and 5% Pt/C. Chromatographic methods for determining the qualitative and quantitative composition of hydrogenation mixtures were developed. The compositions of quinazoline and phthalazine-hydrogenation mixtures were determined. Eight phthalazine-hydrogenation products were detected and isolated: (1) 1,2-dihydrophthalazine, (2) 1,2,3,4-tetrahydrophthalazine, (3) a,a'-diamino-o-xylene, (4) o-methylbenzylamine, (5) 1,3-dihydroisoindole, (6) o-xylene, (7 and 8) cis- and trans- 1,2-dimethylcyclohexane. These products were identified by isolating them from reaction mixtures …

Estimations Of The Effective Electrolytic Surface Area Of Rough And Porous Silver Electrodes ; Ii. Potentiostatic Oxidation Of Silver In Alkaline Electrolyte, James Glenn Bearss

Theses and Dissertations

This dissertation is written in two sections. The first section deals with the development of methods for the estimation of the effective electrolytic surface area of rough and porous silver electrodes in alkaline electrolyte. Data are presented comparing the results of three different methods of surface area estimation. Model pore electrodes were also prepared and oxidized to study the reactions in a pore. Data for constant current oxidations of these electrodes is given. The second section deals with the potentiostatic oxidations of silver in alkaline electrolyte. Data are presented on the total charge acceptance versus applied potential for a potential …

A Study Of Folic Acid Dependent Reactions In Bovine Brain, Dillard Spencer Broderick

Theses and Dissertations

The enzymatic interconversion of serine to glycine and N5, N10-methylene tetrahydrofolate to N5 -methyl tetrahydrofolate have been studied in a cell-free system derived from bovine brain. A partial purification of serine transhydroxymethylase and N5, N10 -methylene tetrahydrofolate reductase has been achieved by ammonium sulfate fractionation, protamine sulfate fraction, and by various column chromatography procedures. The two enzymes studied catalyze sequentially the reductive transfer of the hydroxymethyl group of serine to the N5 position of tetrahydrofolate forming N5 -methyl tetrahydrofolate. The products of these reactions were assayed by the incorporation of C14 from a one-carbon precursor i.e., L-beta-(C14)-serine, or N5 -methyl …

Thermodynamics Of Proton Dissociation And Metal Ion Complexation In Aqueous Solution. I, Cation Binding With Cyclic Polyethers: Significance In Ion Transport Processes. Ii, Proton Dissociation From Adenosine, Several Monosaccharides And Related Compounds. Iii, Proton Dissociation From Several Pyrimidines And Their Nucleosides At 10, 25 And 40°, Joseph Howard Ryttling

Theses and Dissertations

The log K, ΔH° and ΔS° values for the interaction of several metal ions with the two isomers of the cyclic polyether, 2,5,8,15,-18,21 hexaoxatricyclo[20.4.0.0^9,14]hexacosane are reported. The stability order found for alkali metal ion interaction with either isomer is identical to the order of ion permeability through reconstituted biological membranes for structurally related antibiotics. The size of the metal ion is critical in determining the extent of interaction. A calorimetric titration study of proton ionization from several monosaccharides and derivatives, pyrimidine bases and their nucleosides, adenosine and its derivatives, and cycloheptaamylose is described. The heats of reaction obtained in this …

Mechanism Of Water Transport Through Reverse Osmotic Membranes, Cheryl Kay Murphy

Theses and Dissertations

Cellulose acetate membranes show a higher permeability to water than to salt and are being used for desalination of salt water by reverse osmosis. Use of highly acetylated cellulose membranes give a higher salt rejection but also decrease flow rate of the water. The addition of very-short-chain substances or alkyl groups larger than one carbon atom to the cellulose membrane also decreases water flux. A proposed mechanism of transport through the membrane is that the water molecule is passed along the chain by hydrogen bonding with the acetyl groups, The NMR shows a change in the chemical shift of water …

Syntheses Via Modifications Of The Knorr-Paal Procedure :|Ba. Derivatives Of 2,6-Dioxa-10-Azatricyclo[5.2.1.0[Superscript 4,10]]Decane ; B. Highly Sterically Crowded 1,2,5-Trialkylpyrroles And Pyrrolidines, Weldron Severin Burnham

Theses and Dissertations

Earlier work in these laboratories on the heterotricyclic system 2,6-dioxa-10-azatricyclo[5.2.1.04,10]-decane, formed from 1,4-diketones and 2-amino-1,3-propanediols by a product-water-azeotroping procedure, was extended with the synthesis of analogous compounds, e.g., the 1,4,7-triethyl-, 1,7-dimethyl-4-isopropyl-1,7-diethyl-4-isopropyl-, 1,7-dimethyl-3- and 4-phenyl- compounds. The 1,7-dimethyl heterotricycle, the kinetically-controlled product, was accompanied by the thermodynamically-controlled product, 2-(2,5-dimethyl-1-pyrryl)-1,3-propanediol. The 1,7-diethyl heterotricycle was also accompanied by the isomeric pyrrole as were the 1,7-dimethyl-3- and 4-phenyl compounds. A scheme postulating a common intermediate is presented. The interesting analogous compounds, 1,7-dimethyl-2-oxa-6-thia-10-azatricyclo[5.2.1.04,10]decane, 1,4,7-trimethyl-2,6-dioxa-11-azatricyclo[5.3.1.04,11]undecane and 11-hydroxymethyl- and 11-methyl-9,13-dioxa-14- azatetracyclo[6.5.1.02,7 011,14]tetradeca-2,4,6-triene were also prepared. The syntheses in good yields of a considerable number of moderately to …

High Pressure, High Temperature Syntheses Of Selected Lanthanide-Tellurium Compounds, John Francis Cannon

Theses and Dissertations

High pressure, high temperature technics were employed to successfully synthesize HoTe1.7, ErTe1.7, TmTe1.7, LuTe1.7, YTe1.7, and LuTe3. The pressure-temperature regions in which synthesis of each compound is successful were determined. Pressures to 100 kbars concurrently with temperatures to 1200 °C were used in an attempt to prepare ScTe1.7 and ScTe3, but these efforts met with failure. X-ray studies of these new compounds confirmed that they are extensions of the LTe2-X (0≤x

The Thermodynamics Of Transition Metal Chelation In Dilute Aqueous Solution.|Ni.|Pthe Thermodynamics Of Interaction Of Serinate Ion With Divalent Co, Ni, Cu, Zn, And Cd Ions In Aqueous Solution.|Nii.|Pthe Calorimetric Standardization Of Dilute Ferrous Ion Solutions For Use In Determining 2,2'-Bipyridine, Joseph Willard Richards

Theses and Dissertations

Calorimetrically determined ΔH° values are given for the stepwise formation of chelate species between serinate ion and the divalent metal ions of Co, Ni, Cu, Zn, and Cd. These values of ΔH° are compared with those reported in the literature and were combined with values of ΔG° (log K) found in the literature to calculate values of ΔS°. These values of ΔG° and ΔS° are listed also. A new method of standardizing dilute ferrous ion solutions is reported. This procedure makes use of the thermometric titration technique to detect the equivalence point for the reaction of K_2Cr_2O_7 with ferrous ion. …

A Study Of Factors Which May Influence Attitudes Of Lds Teen-Agers Toward Family Home Evening, Don Leroy Miller

Theses and Dissertations

The purpose of this study was to identify factors related to attitudes of teenagers toward the Family Home Evening Program of the Church of Jesus Christ of Latter-day Saints. Hypotheses involving the relationships of certain factors to attitudes toward home evening were tested.

A cluster sample of twenty-three ninth grade classes was selected and data were gathered through use of a questionnaire. Statistics used in analysis of data included the Pearsonian product moment correlation coefficient, and analysis of variance. Responses to open-end questions were content analyzed by three independent judges.

Findings suggest that perceived participation by teenagers in planning and …

A Study Of Earth Science Teachers And Practices In North Dakota For The Academic Year 1968-1969, Howard C. Reith

Theses and Dissertations

In the period between 1961-1964 the North Dakota department of Public Instruction initiated long overdue changes in the science curriculum for the seventh, eighth, and ninth grades of the public schools. Titese involved changes from general science to the life, earth, and physical sciences. During this same period there was a re vitalization of interest in earth science at the national level, with the public school enrollment rising from several thousand to well over one million.

Because of the rapid national growth in earth science enrollment, and the status of earth science in North Dakota, a study to determine the …

A Comparison Of The Late Wisconsinan Molluscan Fauna Of The Missouri Coteau District (North Dakota) With A Modern Alaskan Analogue, Samuel J. Tuthill

Theses and Dissertations

Study of forty fossiliferous sites in late Wisconsinan sediments from the Missouri Coteau district in central North Dakota has defined the molluscan fauna of the period of geologic time between 12,000 and 9,000 C14 years before the present. The fauna includes twenty-eight taxa of nonmarine gastropods and bivalves and is dominated by branchiates. The modern molluscan fauna of the Missouri Coteau district in North Dakota lacks four species which were resident in the late Wisconsinan and contains no unionids, one additional aquatic species, and is strongly dominated by pulmonate gastropods.

The geology of the Missouri Coteau has been interpreted as …

Fort Union (Paleocene) Mollusks From Southern Golden Valley And Southeastern Billings Counties, North Dakota, John J. Delimata

Theses and Dissertations

Nine molluscan species are known to occur in Tongue River Sentinel Butte sediments of parts of Billings, Golden Valley, and Slope Counties in southwestern North Dakota. Tongue River sediments contain all nine of the species which include: two unionids, Plesielliptio priscus (Meek and Hayden) and Rhabdotophorus senec tus (White); one corbulid, Bicorbula mactriformis (Meek and Hayden); and six viviparids, Viviparus retusus (Meek and Hayden), Viviparus trochiformis (Meek and Hayden), Campeloma nebrascensis (Meek and Hayden), Lioplacodes limnaefonnis (Meek and Hayden), Lioplacodes nebrascensis (Meek and Hayden), and Lioplacodes tenuicarinata (Meek and Hayden). Only five of these species (P. priscus, Q. nebrascensis, V. …

The Upper Red River Formation (Ordovician) In Western North Dakota, Harlan K. Friestad

Theses and Dissertations

The upper Red River Formation in Western North Dakota consists of cyclic sedimentary rocks having four main porosity zones which contain most of the oil and gas found in the formation. It was divided into three distinct units that were traced throughout western North Dakota on mechanical logs. In ascending order these are the P, R, and F intervals which consist of alternating sequences of dolomites, limestones, and anhydrites. Facies changes, occur within the P interval both on a regional and a local scale, typically from dense limestones to porous dolomites.

The Kesson anticline and the basin hinge JJ.ne 1-1ere …

Washboard Moraines In Northeastern North Dakota, Dennis N. Nielsen

Theses and Dissertations

The descriptive term 11washboard moraine" has been applied to small transverse till ridges occurring in glaciated regions of North America. Washboard moraines have, in the past, been confused with similar transverse features such as ribbed moraines and De Geer moraines. No previous work had been done on washboard moraines in North Dakota prior to this study. Objectives of this study were to (1) map the distribution of washboard moraines in a selected study area,(2) describe the morphology and composition of washboard moraines, (3) determine the origin !or washboard moraines, and (4) compare data obtained in North Dakota with previously published …

The Effect Of Thiamine And Its Antagonists On Plasma And Tissue Lactic Dehydrogenase In Rats, Dong Hwa Park

Theses and Dissertations

The lactic dehydrogenase activity in plasma and tissues was measured in the thiamine-deprived, the oxythiamine-treated and the pyrithiamine-treated rats as well as the control rats. The lactic dehydrogenase levels of brain and kidney were significantly increased by oxythiamine treatment. The enzyme activity in heart was markedly decreased only in the thiamine-deprived rats. Unlike the above tissues, the enzyme levels in liver were decreased by 29-44 per cent in all three types of thiamine deficiency, However, the enzyme activity in plasma was significantly increased only by pyrithiamine administration. The distribution patterns of lactic dehydrogenase isozymes were electrophoretically examined in these deficiencies. …

Determination Of Stability Constants At 25c For The Interaction In Aqueous Solution Of Serine With Co (Ii), Ni (Ii), Cd (Ii), Zn (Ii), And Cu (Ii) Ions, Liak Hwe Ma

Theses and Dissertations

Values of thermodynamic stability constants at 25°C for the complexes of serine with the metal ions. Co^2+, Ni^2+, Cd^2+, Zn^2+, and Cu^2+ were obtained from pH titration data. All measurements were made in aqueous solution, and data were obtained at three different ionic strengths for each metal ion studied. It was assumed that the activity of the zwitterion is unity. The effect of metal ion hydrolysis upon the log K values was taken into account for the calculations. For all the metal ions studied, stability constants for MA^+, MA_2, and MA_3^- were reported with the exception of copper (II) which …

A Study Of Reaction Parameters In The Hydrogenation Of Acetic Acid By Rhenium Heptoxide Catalyst, Victor L. Mylroie

Theses and Dissertations

Rhenium oxides as well as other rhenium compounds are known to display a broad spectrum of catalytic activity,^25 being resistant to attack by acids under nonoxidizing conditions, and showing a remarkable ability to resist poisoning which is a serious limiting factor in many commonly used catalysts. Rhenium catalysts are cheaper than the platinum metals with the exception of palladium. One of the most remarkable properties of the rhenium catalyst is the ability to catalyze the hydrogenation of carboxylic acids and amides to the corresponding alcohols and amines respectively. The carboxyl group (-COOH) is notoriously difficult to reduce catalytically and most …

High Pressure, High Temperature Syntheses Of Rare Earth Diantimonides And Th₃P₄ Type Polymorphs Of Rare Earth Sesquisulfides, Normal L. Eatough

Theses and Dissertations

The rare earths form series of compounds which are known for several elements but end abruptly or undergo a change of structure at some member of the series. The diantimonides are one such series. Sb-Sb repulsion becomes stronger as the rare earth size decreases and the previously known series ended at Sm. It was felt that high pressure would overcome the Sb-Sb repulsion and allow bonding to form stable or metastable compounds not possible by ordinary techniques. Synthesis studies were carried out on mixtures of antimony with all the rare earths except Pm and with Sc and Y. The known …